losartan and metolazone

losartan has been researched along with metolazone in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's2 (20.00)29.6817
2010's7 (70.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Chan, P; Huang, TY; Ko, JT; Lee, YS; Lin, TS; Tomlinson, B1
Eid, MI; El-Enany, NM; Fathy, ME; Walash, MI1
Dubey, R; Ghosh, M; Muthukrishnan, V; Sinha, BN1
Belal, F; El-Awady, MI; Fathy, ME1

Reviews

1 review(s) available for losartan and metolazone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for losartan and metolazone

ArticleYear
Double-blind comparison of losartan, lisinopril, and metolazone in elderly hypertensive patients with previous angiotensin-converting enzyme inhibitor-induced cough.
    Journal of clinical pharmacology, 1997, Volume: 37, Issue:3

    Topics: Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzothiadiazines; Biphenyl Compounds; Cough; Diuretics; Double-Blind Method; Female; Humans; Hypertension; Imidazoles; Lisinopril; Losartan; Male; Metolazone; Sodium Chloride Symporter Inhibitors; Surveys and Questionnaires; Tetrazoles

1997

Other Studies

8 other study(ies) available for losartan and metolazone

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Simultaneous determination of metolazone and losartan potassium in their binary mixtures using high-performance liquid chromatography with fluorimetric detection: application to combined tablets and spiked human plasma.
    Luminescence : the journal of biological and chemical luminescence, 2014, Volume: 29, Issue:5

    Topics: Antihypertensive Agents; Chromatography, High Pressure Liquid; Diuretics; Drug Combinations; Fluorometry; Humans; Losartan; Metolazone; Tablets

2014
Simultaneous Determination and Pharmacokinetics of Metolazone, Losartan and Losartan Carboxylic Acid in Rat Plasma by HPLC-ESI-MS-MS.
    Journal of chromatographic science, 2015, Volume: 53, Issue:9

    Topics: Animals; Chromatography, High Pressure Liquid; Linear Models; Losartan; Male; Metolazone; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2015
Simultaneous determination of metolazone and losartan in their combined tablets using synchronous fluorescence spectroscopy.
    Luminescence : the journal of biological and chemical luminescence, 2019, Volume: 34, Issue:6

    Topics: Antihypertensive Agents; Fluorescence; Losartan; Metolazone; Spectrometry, Fluorescence; Tablets

2019