losartan has been researched along with hydrochlorothiazide in 301 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 26 (8.64) | 18.2507 |
| 2000's | 121 (40.20) | 29.6817 |
| 2010's | 144 (47.84) | 24.3611 |
| 2020's | 10 (3.32) | 2.80 |
| Authors | Studies |
|---|---|
| Grassl, SM; Holtzman, EJ; Race, JE; Williams, WJ | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Avdeef, A; Tam, KY | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Bauer, IH; Lau-Sieckman, A; Reams, GP; Wu, Z | 1 |
| Goldberg, AI; Pratt, JH; Soffer, BA; Sweet, CS; Wiens, B; Wright, JT | 1 |
| Carroll, J; Grossman, E; Peleg, E; Rosenthal, T; Shamiss, A | 1 |
| Brunner, H; Dobbins, TW; Faison, EP; Irwin, R; Karlberg, BE; Lacourcière, Y; Nelson, EB; Ramsay, LE; Snavely, DB | 1 |
| Dunlay, MC; Goldberg, AI; Sweet, CS | 1 |
| Bader, B; Braun, N; Erley, CM; Risler, T; Scheu, M; Wolf, S | 1 |
| Faison, EP; Lacourcière, Y; Lefebvre, J; Nakhle, G; Nelson, EB; Snavely, DB | 1 |
| Goldberg, MR; Katz, SA; Opsahl, JA | 1 |
| Arcuri, KE; Goldberg, AI; MacKay, JH; Snapinn, SM; Sweet, CS | 1 |
| Chrysant, S; Dunlay, MC; Fitzpatrick, V; Francischetti, EA; Goldberg, AI; Sweet, CS | 1 |
| Ramsay, LE; Yeo, WW | 2 |
| Capra, NL; Goldberg, MR; Hsieh, JY; Lin, CC; Lo, MW; McCrea, JB; Tomasko, L | 1 |
| Arcuri, KE; Goldberg, AI; Ruilope, LM; Simpson, RL; Sweet, CS; Toh, J | 1 |
| Acitorio, M; Aquino, D; Caccavale, A; Coppolino, P; Cosimi, R; Iacono, A; Iarussi, D; Ratti, G; Rocereto, A; Tedesco, MA | 1 |
| Helmchen, U; Schneider, A; Stahl, RA; Wenzel, U; Wolf, G | 1 |
| Drewe, J; Gasser, P; Martina, B; Weinbacher, M | 1 |
| Aquino, D; di Salvo, G; Galzerano, D; Iacono, A; Iarussi, D; Limongelli, G; Mennella, S; Ratti, G; Tedesco, MA | 1 |
| Barr, E; Conlin, PR; Edelman, JM; Elkins, M; Liss, C; Vrecenak, AJ | 1 |
| Anderson, NH; Devlin, AM; Dominiczak, AF; Graham, D; Hamilton, CA; Morton, JJ; Reid, JL; Schork, NJ | 1 |
| Sever, PS | 1 |
| Grieco, M; Iacono, A; Iarussi, D; Manzo, G; Mennella, S; Rainone, AC; Ratti, G; Tedesco, MA | 1 |
| Battegay, E; Dieterle, T; Martina, B; Weinbacher, M | 1 |
| Fitzgerald, D; Kelly, L; Nallen, R; O'Brien, E; Owens, P; Ryan, D | 1 |
| Fasce, E; Wagemann, H | 1 |
| Grote, L; Hedner, J; Kraiczi, H; Peker, Y | 1 |
| Düsing, R; Hertfelder, HJ; Lottermoser, K; Vetter, H | 1 |
| Baiz, AQ; Bortman, G; Farsang, C; Garcia-Puig, J; Niegowska, J; Vrijens, F | 1 |
| Carlucci, G; Mazzeo, P; Palumbo, G; Quaglia, MG | 1 |
| Benemio, G; Bruni, B; Porcellati, C; Reboldi, GP; Sacchi, N; Schillaci, G; Verdecchia, P | 1 |
| Bélanger, A; Godin, C; Hallé, JP; Lacourcière, Y; Marion, J; Ross, S; Wright, N | 1 |
| Barragan, J; Bernhardi, DC; Bunt, T; Cabrera, WJ; Dumortier, T; Grossman, E; Jacovides, A; Jelakovic, B; Manolis, AJ; Matadamas, N; Mejia, AD; Mendiola, A; Smith, RD; Watanabe, LA; Woo, KS; Zhu, JR | 1 |
| Aurup, P; Goldberg, A; Oparil, S; Snavely, D | 1 |
| Erk, N | 1 |
| Abe, I; Kagiyama, S; Lin, Y; Matsumura, K; Tsuchihashi, T | 1 |
| Aznar, J; Llisterri, JL; Lozano, JV; Redon, J | 1 |
| Crespo, MJ; De Mello, WC | 1 |
| Brenner, BM; Remuzzi, G; Ruggenenti, P | 1 |
| Alderman, M; Alexander, J; Ceesay, P; Espenshade, M; Flack, JM; Goldberg, A; Gradman, A; Green, S; Kraus, WE; Lester, FM; Pratt, JH; Saunders, E; Vargas, R | 1 |
| Elisaf, MS; Milionis, HJ; Nikas, S | 1 |
| de Pablos-Velasco, PL; Esmatjes, JE; Fernandez-Vega, F; Lopez de la Torre, ML; Pazos Toral, F; Pozuelo, A; Ruilope, LM | 1 |
| Fastbom, J; Gerth, W; Jönsson, L | 1 |
| Abe, I; Eto, K; Iida, M; Tsuchihashi, T | 1 |
| Chen, Q; Feng, L; Gordon, KL; Han, L; Johnson, RJ; Kanellis, J; Kang, DH; Lan, HY; Mazzali, M; Nakagawa, T; Watanabe, S; Xia, YY | 1 |
| Coca, A; de la Sierra, A; Felip, A; Mínguez, A; Pelegrí, A; Plana, J; Sobrino, J; Soler, J; Vila, J | 1 |
| Armenteros, S; Fernández González, R; Garrido, J; Goicolea, I; Martínez, JM; Moreno Carretero, E; Piniés, J | 1 |
| Carlucci, G; Donati, E; Fanali, S; Mazzeo, P; Quaglia, MG | 1 |
| Brady, WE; Gazdick, LP; Gradman, AH; Lyle, P; Zeldin, RK | 1 |
| Aurup, P; Beevers, G; Dahlöf, B; de Faire, U; Devereux, RB; Edelman, J; Fyhrquist, F; Ibsen, H; Julius, S; Kjeldsen, SE; Kristianson, K; Lederballe-Pedersen, O; Lindholm, LH; Nieminen, MS; Omvik, P; Oparil, S; Snapinn, S; Wedel, H | 1 |
| Fang, X; Hertzog, DL; McCafferty, JF; Reed, RA; Tyrrell, RJ | 1 |
| Bassett, ML; Fisher, AA | 1 |
| Klein, C; Meinicke, TW; Neutel, JM; Schumacher, H | 1 |
| Feely, J; Mahmud, A | 1 |
| Brown, NJ; Kumar, S; Painter, CA; Vaughan, DE | 1 |
| Boomsma, F; van den Meiracker, AH; van der Linde, NA | 1 |
| Adams, MA; Bushfield, TL; Hale, TM; Woolard, J | 1 |
| Dahlöf, B; Devereux, RB; Jern, S; Nieminen, MS; Oikarinen, L; Okin, PM; Papademetriou, V; Toivonen, L; Viitasalo, M; Wachtell, K | 1 |
| Babadzhan, VD | 1 |
| Byrne, M; Gil-Extremera, B; Lacourcière, Y; Mueller, O; Williams, L | 1 |
| Dickson, TZ; Lin, CC; Lo, MW; Ramjit, D; Ritter, MA; Shahinfar, S; Snavely, D; Zagrobelny, J | 1 |
| Kolloch, RE; Meinicke, TW; Neutel, JM; Plouin, PF; Schumacher, H | 1 |
| Preobrazhenskiĭ, DV; Sidorenko, BA; Stetsenko, TM; Tarykina, EV; Tsurko, VV | 1 |
| Baumgart, P | 1 |
| Ong, HT | 1 |
| Chazova, IE; Dmitriev, VV; Ratova, LG; Sinitsin, VE; Stukalova, OV | 1 |
| Bulatov, VA; Os, I; Podzolkov, VI; Son, EA | 1 |
| Chen, L; Gao, R; Jiang, B; Li, J; Li, Y; Liu, G; Su, L | 1 |
| Lacourcière, Y; Poirier, L | 1 |
| Alonso, C; Catalán, MP; Egido, J; Gallego-Delgado, J; Gómez-Garre, D; Largo, R; Ortiz, A; Plaza, JJ; Soto, K; Tejera, N | 1 |
| Calvo, C; Campo, C; de la Sierra, A; Delgadillo, J; García-Puig, J; Gil-Extremera, B; Márquez, E; Oliván, J; Pontes, C; Roca Cusachs, A; Sanz de Castro, S | 1 |
| Bulatov, VA; Makolkin, VI; Podzolkov, VI; Son, EA | 1 |
| Arakawa, K | 1 |
| Beevers, DG; Chung, NA; Lip, G | 1 |
| Bakris, GL; Demopoulos, LA; Fox, JC; Gleim, GW; Leight, K; Lewin, AJ; Sutradhar, SC | 1 |
| Bäcklund, T; Eriksson, A; Finckenberg, P; Gröholm, T; Laine, M; Mervaala, E; Palojoki, E; Saraste, A; Tikkanen, I | 1 |
| Alpan, RS; Erenmemisoglu, A; Koytchev, R; Ozalp, Y; van der Meer, MJ | 1 |
| Demopoulos, L; Gradman, AH; Mukherjee, R; Salerno, CM | 1 |
| Cindrić, T; Lusina, M; Musulin, N; Peko, M; Pozaić, L; Tomaić, J | 1 |
| Arbab-Zadeh, A; Fu, Q; Levine, BD; Okazaki, K; Prasad, A; Witkowski, S; Zhang, R | 1 |
| Berman, S; Dishy, V; Golik, A; Koren-Michowitz, M; Weissgarten, J; Yona, O; Zaidenstein, R | 1 |
| Frohlich, ED; Matavelli, LC; Ono, H; Zhou, X | 1 |
| Malliani, A; Montano, N | 1 |
| Bayraktutan, U; Demirci, B; McKeown, PP | 1 |
| Adams, MA; Hale, TM; Hannan, JL; Heaton, JP; Smallegange, C | 1 |
| Chrysant, SG; Littlejohn, TW; Neutel, JM; Singh, A | 1 |
| Lacourcière, Y; Neutel, JM; Schumacher, H | 1 |
| Ishimitsu, T; Matsuoka, H; Minami, J | 1 |
| Appleton, CP; Kitzman, DW; Klein, A; Little, WC; Wesley-Farrington, DJ; Zile, MR | 1 |
| Coelho, EB; da Silva, CA; Fazan, R; Nobre, F; Salgado, HC | 1 |
| Apostolou, C; Dotsikas, Y; Kolocouri, F; Kousoulos, C; Loukas, YL | 1 |
| Feig, PU; Gleim, GW; Littlejohn, TW; Lyle, PA; Rubino, J; Shahinfar, S; Soffer, BA; Zhang, H | 1 |
| Agharazii, M; Larivière, R; Lebel, M; Rodrigue, ME | 1 |
| Dahlöf, B; de Faire, U; Devereux, RB; Fyhrquist, F; Harris, KE; Hille, DA; Ibsen, H; Kjeldsen, SE; Lederballe-Pedersen, O; Lindholm, LH; Nieminen, MS; Omvik, P; Oparil, S; Wedel, H | 1 |
| Hannila-Handelberg, T; Hiltunen, TP; Kontula, K; Miettinen, HE; Paavonen, KJ; Pentikäinen, PJ; Strandberg, T; Suonsyrjä, T; Tikkanen, I; Tilvis, R; Virolainen, J | 1 |
| Fujihara, CK; Malheiros, DM; Zatz, R | 1 |
| Claassen, JA; Fu, Q; Levine, BD; Witkowski, S; Zhang, R | 1 |
| Abe, C; Akashiba, A; Ishimitsu, T; Kameda, T; Matsuoka, H; Minami, J; Takahashi, T | 1 |
| Lacourcière, Y; Lefebvre, J; Poirier, L | 1 |
| Bestehorn, K; Wahle, K | 1 |
| Chiara Cavallini, M; Palmieri, V; Pini, R | 1 |
| Biswas, SK; de Faria, JB; de Faria, JM; Pinto, CC; Silva, KC; Souza, DS | 1 |
| Høieggen, A; Kizer, JR; Kjeldsen, SE; Lyle, PA; Oparil, S; Os, I | 1 |
| Barba, J; Castellano, JM; Díez, J; González, A; López, B | 1 |
| Hirayama, Y; Matsuoka, H; Nonaka, K; Ogihara, T; Saruta, T; Suzuki, H; Takahashi, K; Toki, M | 1 |
| Bestehorn, K; Förster, A; Jung, C; Smolka, W | 2 |
| Argiolas, G; Baraccani, C; Bardini, M; Bernini, G; Bulla, E; Bulla, P; Cocco, F; Cusi, D; Degli Esposti, E; Degortes, S; Fadda, S; Fallo, F; Ferri, C; Filigheddu, F; Frau, F; Glorioso, N; Macciardi, F; Malatino, L; Mulatero, P; Parati, G; Perticone, F; Pinna Parpaglia, P; Pitzoi, S; Regolisti, G; Sciacqua, A; Stancanelli, B; Troffa, C; Veglio, F; Williams, TA; Zaninello, R | 1 |
| Fujita, T; Gohchi, K; Shimosawa, T; Yatomi, Y | 1 |
| Boomsma, F; de Zeeuw, D; Navis, G; Vogt, L; Waanders, F | 1 |
| Bacher, P; Bakris, G; Champion, A; Molitch, M; Sarafidis, P; Sowers, JR; Zhou, Q | 1 |
| Fogari, R; Kohlmann, O; Laurent, S; Roca-Cusachs, A; Schmieder, RE; Triposkiadis, F; Wenzel, RR | 1 |
| Abate, N; Chen, E; Creager, MA; Galet, V; Jia, G; Julius, S; Lerman, A; Lyle, PA; Oparil, S; Pool, J; Tershakovec, AM | 1 |
| Donner, K; Hannila-Handelberg, T; Hiltunen, TP; Kontula, K; Miettinen, HE; Paavonen, KJ; Pentikäinen, PJ; Strandberg, T; Suonsyrjä, T; Tikkanen, I; Tilvis, R | 1 |
| Cerdà, V; Estela, JM; Obando, MA | 2 |
| Amann, K; Hartner, A; Hilgers, KF; Klanke, B; Melk, A; Steinbach, MP; Westhoff, JH | 1 |
| Castellano, PM; Kaufman, TS; Maggio, RM | 1 |
| Bestehorn, K; Diener, HC; Haller, H; Jung, C; Lüders, S; Schmieder, RE; Schrader, J; Smolka, W; Wahle, K | 1 |
| Dabek, J; Hannila-Handelberg, T; Hiltunen, TP; Kontula, K; Nieminen, MS; Oikarinen, L; Porthan, K; Suonsyrja, T; Toivonen, L; Vaananen, H; Viitasalo, M; Virolainen, J | 1 |
| Mourad, JJ; Waeber, B | 1 |
| Schoenberger, JA | 1 |
| Abolfathi, Z; Almeida, S; Filipe, A; Neves, R; Ortuño, J; Spínola, AC; Yritia, M | 1 |
| Bonventre, JV; Damman, K; Hamming, I; Leuvenink, H; Navis, G; Vaidya, VS; van Goor, H; Vogt, L; Waanders, F | 1 |
| Donner, K; Fodstad, H; Hannila-Handelberg, T; Hiltunen, TP; Kontula, K; Suonsyrjä, T | 1 |
| Cattaneo, D; Perico, N; Remuzzi, G | 1 |
| Claassen, JA; Levine, BD; Zhang, R | 1 |
| Furukata, S; Ishimitsu, T; Matsuoka, H; Minami, J | 1 |
| Bestehorn, K; Bönner, G; Jung, C; Smolka, W | 1 |
| Araki, SI; Haneda, M; Isshiki, K; Kanasaki, M; Kashiwagi, A; Koya, D; Kume, S; Sakaguchi, M; Sugiomoto, T; Uzu, T; Yokomaku, Y | 1 |
| Fogari, R; Kohlmann, O; Laurent, S; Roca-Cusachs, A; Schmieder, RE; Wenzel, RR | 1 |
| Buranakitjaroen, P; Fan, WH; Kim, BS; Kim, KS; Kim, YD; Lin, WH; Massaad, R; Ngau, YY; Santos, M; Smith, RD; Tong, P; Zhu, W | 1 |
| Dallinga-Thie, GM; Dikkeschei, LD; Dullaart, RP; Krikken, JA; Navis, GJ; Vogt, L; Waanders, F | 1 |
| Basavanagowdappa, H; Chandurkar, N; Kumar, A; Pareek, A; Zawar, S | 1 |
| Keating, GM | 1 |
| Abe, M; Maruyama, T; Matsumoto, K; Okada, K | 2 |
| Brody, R; Grossman, E; Peleg, E; Sharabi, Y | 1 |
| Abe, M; Matsumoto, K; Okada, K | 1 |
| Ichihara, A; Itoh, H; Kinouchi, K; Kurauchi-Mito, A; Sakoda, M | 1 |
| Andraus, MH; Azevedo, CP; Borges, BC; Borges, NC; Moreira, RF; Moreno, RA; Salvadori, MC | 1 |
| Bubnova, MG; Oganov, RG | 1 |
| Ayabe, T; Eto, T; Etoh, T; Ichiki, Y; Kato, J; Kita, T; Kitamura, K; Tamaki, N; Yokota, N | 2 |
| Burnier, M; Coltamai, L; Maillard, M; Simon, A; Vogt, B | 1 |
| Bastien, N; Hamet, P; Longo, N; Racine, N; Sampalis, JS | 1 |
| Hemmelder, MH; Kluin-Nelemans, HC; Laverman, GD; Navis, G; Sinkeler, SJ; Slagman, MC; Vogt, L; Waanders, F | 1 |
| Dahlöf, B; Devereux, RB; Edelman, JM; Hille, DA; Kjeldsen, SE; Lindholm, LH; Okin, PM | 1 |
| Ekman, M; Fragoulakis, V; Maniadakis, N; Papagiannopoulou, V; Yfantopoulos, J | 1 |
| Thornton, SN | 1 |
| Gorski, JC; Lindamood, C; Ortiz, S; Rackley, R; Shaw, A | 1 |
| Cameron, A; Ewen, M; Laing, RO; van Mourik, MS | 1 |
| Ambrosioni, E; Bombelli, M; Cerasola, G; Cipollone, F; Ferri, C; Grazioli, I; Leprotti, C; Mancia, G; Melzi, G; Mugellini, A; Mulè, G; Palasciano, G; Salvetti, A; Trimarco, B | 1 |
| Angeli, F; Mazzotta, G; Reboldi, G; Verdecchia, P | 1 |
| Hu, ZP; Qian, HY; Wang, BN; Wang, Y; Wei, W; Zhou, Q | 1 |
| Cervenka, L; Chábová, VČ; Husková, Z; Kompanowska-Jezierska, E; Kopkan, L; Kramer, HJ; Kujal, P; Malý, J; Netuka, I; Opočenský, M; Rakušan, D; Sadowski, J; Schejbalová, S; Skaroupková, P; Vaněčková, I; Vaňourková, Z; Vernerová, Z; Walkowska, A | 1 |
| Fujiki, K; Kinoshita, H; Kobayashi, K; Koga, N; Tomiyama, J; Yaguramaki, T; Yakushiji, F; Yasuda, M | 1 |
| Cunha, FM; Fontes, V; Gusmão, JL; Ignez, EC; Mano, GP; Mion, D; Nishiura, JL; Ortega, KC; Pierin, AM; Segre, CA; Ventura, CG | 1 |
| Azuma, K; Okano, Y; Tamura, K; Toya, Y; Umemura, S; Yabana, M | 1 |
| Argiolas, G; Bianchi, G; Carpini, SD; Citterio, L; Cusi, D; Ferrandi, M; Ferrari, P; Glorioso, N; Lanzani, C; Macciardi, F; Manunta, P; Messaggio, E; Salvi, E; Staessen, JA; Tripodi, G; Valentini, G | 1 |
| Divya, O; Nagavalli, D; Sankar, AS; Santha, A; Vaidhyalingam, V | 1 |
| Hirose, H; Kawabe, H; Saito, I | 1 |
| Chavan, UB; Deshpande, AD; Dighe, SB; Jagdale, SN; Kothapalli, LP; Nanda, RK; Thomas, AB | 1 |
| Islam, MZ; Rahman, MS | 1 |
| Hosseini, F; Mahmoudian, M; Nemati, F; Rahbar-Roshandel, N; Shafiei, M | 1 |
| Balink, H; de Graaf, W; Grond, J; Hemmelder, MH | 1 |
| Furukawa, M; Hattori, T; Murase, T; Murohara, T; Nagata, K; Nishiyama, A; Ohtake, M; Tsuboi, K; Ueyama, J; Yamada, Y | 1 |
| Circelli, M; Cremonesi, G; Fogari, R; Mugellini, A | 1 |
| Kohagura, K; Nakada, S; Nakamoto, M; Ohshiro, K; Ohya, Y; Sakima, A; Tana, T; Yamazato, M | 1 |
| Handler, J | 1 |
| Fanelli, C; Fernandes, BH; Fujihara, CK; Machado, FG; Malheiros, DM; Okabe, C; Zatz, R | 1 |
| Inoue, A; Mitsutake, R; Miura, S; Saku, K; Shiga, Y; Uehara, Y | 1 |
| Goldschmeding, R; Hemmelder, MH; Laverman, GD; Navis, G; Nguyen, TQ; Slagman, MC; Vogt, L; Waanders, F | 1 |
| Akashiba, A; Furukata, S; Ishimitsu, T; Matsuoka, H; Minami, J; Nakano, N; Numabe, A; Ohno, E | 1 |
| Duprez, D; Ferdinand, KC; Purkayastha, D; Samuel, R; Wright, RF | 1 |
| Iimori, K; Ikeda, H; Inoue, T; Ishida, S; Kamura, A; Kato, T; Kuroki, S; Naitoh, H; Node, K; Tamesue, S | 1 |
| Guo, Q; Hu, C; Ito, S; Jiang, Y; Mori, T; Nakamichi, T; Ogawa, S; Ohsaki, Y; Sato, H; Yoneki, Y | 1 |
| Kawecka-Jaszcz, K; Rajzer, M; Undas, A; Wojciechowska, W | 1 |
| Kohagura, K; Nakada, S; Ohshiro, K; Ohya, Y; Sakima, A; Tana, T; Yamazato, M | 1 |
| Islam, F; Jamali, SN; Khan, M; Khan, RA; Laghari, J | 1 |
| Prior, SJ | 1 |
| Donner, KM; Hannila-Handelberg, T; Hiltunen, TP; Kontula, K; Suonsyrjä, T | 1 |
| Fukuda, S; Ishii, K; Ito, H; Iwakura, K; Kasayuki, N; Kihara, H; Nakamura, F; Shimada, K; Yoshikawa, J | 1 |
| Inoue, A; Kuwano, T; Mitsutake, R; Miura, S; Morii, J; Saku, K; Shiga, Y; Uehara, Y | 1 |
| Iwanaga, K; Kakemi, M; Miyazaki, M; Shimizu, R | 1 |
| Akaba, K; Endo, S; Fukui, A; Gomi, H; Hamaguchi, A; Hanaoka, K; Hara, Y; Hasegawa, T; Hayakawa, H; Hayashi, F; Hikida, M; Hirano, K; Horiguchi, M; Hosoya, M; Hosoya, T; Ichida, K; Ikeda, M; Imai, T; Ishii, T; Ishikawa, H; Ishikawa, M; Kameda, C; Kanai, T; Kasai, T; Kawamura, T; Kobayashi, A; Kobayashi, H; Kurashige, M; Kuriyama, S; Kusama, Y; Maezawa, H; Maezawa, Y; Maruyama, Y; Matsuda, H; Matsuo, N; Matsuo, T; Miura, Y; Miyajima, M; Miyakawa, M; Miyazaki, Y; Mizuguchi, M; Morita, T; Nakao, M; Nokano, H; Ogura, M; Ohkido, I; Ohno, I; Ohtsuka, Y; Okada, K; Okamoto, H; Okonogi, H; Saikawa, H; Saito, H; Sekiguchi, C; Soejima, M; Suetsugu, Y; Sugano, N; Suzuki, T; Takahashi, H; Takahashi, Y; Takamizawa, S; Takane, K; Takazoe, K; Tanaka, H; Tanaka, S; Terawaki, H; Tokudome, G; Tomonari, H; Toyoshima, R; Tsuboi, N; Udagawa, T; Ueda, H; Ueda, Y; Uetake, M; Unemura, S; Utsunomiya, M; Utsunomiya, Y; Yamada, T; Yamada, Y; Yamaguchi, Y; Yamamoto, H; Yokoo, T; Yokoyama, K; Yonezawa, H; Yoshida, H; Yoshida, M; Yoshizawa, T | 1 |
| Eto, K; Fujimori, S; Ogata, N; Oka, Y | 1 |
| Duprez, D; Ferdinand, K; Purkayastha, D; Samuel, R; Wright, R | 1 |
| Inou, T; Kobayashi, K; Kubara, I; Meno, H; Nakamura, Y; Ota, T; Shiga, Y; Tanaka, M; Tsuchiya, Y | 2 |
| Dahlöf, B; Devereux, RB; Kjeldsen, SE; Lindholm, LH; Okin, PM | 1 |
| Berwanger, O; Mion Júnior, D; Ortega, KC; Silva, GV; Tsuji, RL | 1 |
| Aoun, J; Girerd, X; Rosenbaum, D | 1 |
| Imaizumi, T; Kai, H; Ueda, T | 1 |
| Kobayashi, M; Kuroda, H; Ogasawara, K; Ogawa, A; Saura, H; Suzuki, T; Terasaki, K; Yamashita, T | 1 |
| Arima, H; Fujii, K; Fukuhara, M; Kato, I; Kawasaki, J; Matsumura, K; Morinaga, Y; Ohta, Y; Ohtsubo, T; Otonari, T; Sasaguri, T; Tominaga, M; Tsuchihashi, T; Uezono, K | 3 |
| Matsubara, H; Miyagawa, S; Yamada, H | 1 |
| Cheng, XW; Murohara, T | 1 |
| Danser, AH; Fenton, RA; Hoorn, EJ; Lim, CH; Meima, ME; Mutig, K; Rosenbaek, LL; van der Lubbe, N; van Veghel, R; Zietse, R | 1 |
| Ashek, A; Bailey, MA; Bellamy, CO; Flatman, PW; Harmar, AJ; Kenyon, CJ; Menzies, RI; Mullins, JJ; Mullins, LJ | 1 |
| Asayama, K; Hashimoto, T; Hirose, T; Imai, Y; Inoue, R; Kikuya, M; Metoki, H; Obara, T; Ohkubo, T; Sato, M | 1 |
| Eguchi, K; Fukutomi, M; Hoshide, S; Kabutoya, T; Kario, K; Watanabe, T | 1 |
| Miura, S; Saku, K | 1 |
| Adachi, M; Kinoshita, A; Koh, N; Maeda, K; Miura, Y; Murohara, T | 1 |
| Arafat, T; Idkaidek, N | 1 |
| Emoto, N; Hirata, K; Inoue, Y; Ishida, T; Kitagawa, Y; Miki, T; Nishimura, K; Nonaka, H; Suematsu, M; Toh, R | 1 |
| Morris, JK; Wald, DS; Wald, NJ | 1 |
| Imaizumi, T; Kai, H | 1 |
| Hosoya, T; Kobayashi, A; Kuriyama, S; Ohno, I; Otsuka, Y; Yoshizawa, T | 1 |
| Fukuda, S; Ishii, K; Ito, H; Iwakura, K; Shimada, K; Takami, T; Watanabe, H; Yoshikawa, J | 1 |
| Glezer, MG; Saĭgitov, RT | 1 |
| Fujiwara, K; Shimada, Y; Suzuki, H | 1 |
| Hokimoto, S; Kaikita, K; Kan, H; Ogawa, H; Sugiyama, S; Sumida, H; Takashio, S; Tayama, S; Yamamoto, K; Yamamuro, M | 1 |
| Hanayama, Y; Makino, H; Nakamura, Y; Uchida, HA | 1 |
| Ashihara, T; Enomoto, D; Higaki, J; Irita, J; Jotoku, M; Matsuoka, H; Miyoshi, K; Nagao, T; Okura, T; Watanabe, K | 1 |
| Arias, SC; Camara, NO; de Brito, T; Fanelli, C; Fujihara, CK; Machado, FG; Malheiros, DM; Origassa, CS; Valente, CP; Zatz, R | 1 |
| Eguchi, K; Fukutomi, M; Hoshide, S; Kario, K; Watanabe, T | 1 |
| Adachi, H; Imaizumi, T; Kai, H; Kaneyuki, M; Kusaba, K; Mitsutake, Y; Shihara, M; Toyama, Y; Ueda, T; Umei, H | 1 |
| Ayaori, M; Higashi, K; Hosoai, H; Ikewaki, K; Kijima, F; Nakamura, H; Nashida, Y; Nishiwaki, M; Shige, H; Shimizu, S; Yamashita, T; Yokoyama, M | 1 |
| Hasebe, N; Kikuchi, K; Koyama, S; Maruyama, J; Morimoto, H; Morita, K; Saijo, Y; Sano, H; Sasagawa, Y; Sato, N; Sumitomo, K; Takehara, N; Takeuchi, T | 2 |
| Baba, Y; Fukuda, M; Kato, S; Maeda, K; Nishi, S; Nishimura, H; Ohashi, S; Okuda, J; Otoshi, K; Shintani, M | 1 |
| Cornelissen, G; Halberg, F; Otsuka, K; Watanabe, Y | 1 |
| Dahlöf, B; Devereux, RB; Hille, DA; Kjeldsen, SE; Lindholm, LH; Okin, PM; Wiik, BP | 1 |
| Asakura, J; Fukada, H; Hasegawa, H; Kanozawa, K; Kogure, H; Komuro, O; Matsuzawa, M; Mitarai, T; Takayanagi, K; Tokushima, H | 1 |
| Hanaoka, K; Hasegawa, T; Kaizu, K; Kamata, K; Kimura, K; Kobayashi, S; Morita, S; Ohtake, T; Oshikawa, J; Sato, T; Taguri, M; Toya, Y; Umemura, S; Yasuda, G | 1 |
| Hamada, T; Haruaki, N; Hirota, Y; Hisatome, I; Kato, M; Kosaka, H; Kotake, H; Kuwabara, M; Miyazaki, S; Mizuta, E; Nakamura, H; Ogino, K; Ohtahara, A; Omodani, H; Taniguchi, S; Watanabe, A; Watanabe, M; Yamamoto, K | 1 |
| Soucek, M; Spinar, J; Vitovec, J | 1 |
| Diniz, R; Ferreira, FF; Reis do Carmo, W | 1 |
| Dobrokhod, AS; Kushnir, SM; Radchenko, GD; Sirenko, YM; Torbas, OO | 1 |
| Asakura, J; Hasegawa, H; Iwashita, T; Kawashima, K; Matsuda, A; Mitarai, T; Nakamura, T; Ogawa, T; Shimizu, T; Takayanagi, K; Tayama, Y | 1 |
| Jain, R; Khuroo, A; Kumar, S; Kurachi, K; Monif, T; Reyar, S; Singla, AK | 1 |
| Chazova, IE; Martyniuk, TV | 1 |
| Friedman, RL; Hoehns, JD; Lallier, TS; McDougall, DJ | 1 |
| O'Prinsen, AC; Pechlivanoglou, P; Postma, MJ; Schuiling-Veninga, N; Stevanović, J; Verheggen, BG | 1 |
| Aizawa, T; Amino, M; Deguchi, Y; Ikari, Y; Kanda, S; Tanabe, T; Yoshioka, K | 1 |
| Mori, H; Nishida, K; Okada, Y; Tanaka, Y; Uriu, K; Yamamoto, S | 1 |
| Fujisaki, K; Higashi, H; Hirakata, H; Kanai, H; Katafuchi, R; Kitazono, T; Nakano, T; Nakayama, M; Taniguchi, M; Tsuruya, K | 1 |
| Azuma, K; Fujimoto, G; Fujita, KP; Hanson, ME; Nishida, C; Numaguchi, H; Rakugi, H; Shimada, K; Shirakawa, M; Tsuchihashi, T; Yamaguchi, H | 1 |
| Fujisawa, K; Hitaka, Y; Inoue, A; Koyoshi, R; Kuwano, T; Matsunaga, E; Miura, S; Morii, J; Nagata, I; Norimatsu, K; Saku, K; Shiga, Y; Shirotani, T; Uehara, Y | 1 |
| Ahn, T; Bae, JH; Han, KR; Hyon, MS; Kim, WH; Kim, YK; Lee, SU; Lim, DS; Park, HK; Suh, SY | 1 |
| Azushima, K; Kobayashi, R; Ohki, K; Ohsawa, M; Sakai, M; Tamura, K; Tokita, Y; Umemura, S; Uneda, K; Wakui, H | 1 |
| Azuma, K; Fujita, KP; Nishida, C; Numaguchi, H; Rakugi, H; Shimada, K; Shirakawa, M; Tsuchihashi, T; Yamaguchi, H | 2 |
| Asayama, K; Elnagar, N; Hosaka, M; Imai, Y; Kojima, I; Metoki, H; Miyawaki, Y; Obara, T; Ohkubo, T; Satoh, M | 1 |
| Fujiwara, H; Furukawa, Y; Kita, Y; Matsuda, M; Miyazaki, S; Sato, Y; Sawa, T; Takatsu, Y; Tanaka, M | 1 |
| Goda, A; Masuyama, T | 1 |
| Nagata, M; Takase, B | 1 |
| Fujiwara, K; Shimada, K; Suzuki, H | 1 |
| Argiolas, G; Bardini, M; Barlassina, C; Bernini, G; Boerwinkle, E; Braga, D; Bulla, E; Bulla, P; Chittani, M; Cusi, D; Degli Esposti, E; Desideri, G; Fallo, F; Ferri, C; Frau, F; Fresu, G; Galletti, F; Glorioso, N; Glorioso, V; Hiltunen, TP; Kontula, K; Lanzani, C; Malatino, L; Manunta, P; Mulatero, P; Ortu, MF; Perticone, F; Piras, DA; Pitzoi, S; Regolisti, G; Salvi, E; Sciacqua, A; Scioli, GA; Semplicini, A; Stancanelli, B; Sturani, A; Troffa, C; Turner, ST; Veglio, F; Velayutham, D; Williams, TA; Zaninello, R | 1 |
| Boerwinkle, E; Chapman, AB; Cooper-DeHoff, RM; Donner, KM; Frau, F; Glorioso, N; Glorioso, V; Gong, Y; Gums, JG; Hiltunen, TP; Johnson, JA; Kontula, KK; Ripatti, S; Saarela, J; Salvi, E; Sarin, AP; Turner, ST; Zaninello, R | 1 |
| Hayashi, M; Iino, Y; Kawamura, T; Kuwahara, M; Nangaku, M; Uchida, S | 1 |
| Argiolas, G; Barlassina, C; Boerwinkle, E; Braga, D; Carpini, SD; Chapman, AB; Chittani, M; Citterio, L; Condorelli, G; Cooper-Dehoff, RM; Cusi, D; Dominiczak, AF; Donner, KM; Frau, F; Fresu, G; Glorioso, N; Glorioso, V; Gong, Y; Hiltunen, TP; Johnson, JA; Kontula, KK; Lanzani, C; Manunta, P; Melander, O; Ortu, MF; Padmanabhan, S; Piras, DA; Pozzoli, S; Rivera, NV; Salvi, E; Simonini, M; Trimarco, B; Troffa, C; Turner, ST; Velayutham, D; Zaninello, R | 1 |
| Ago, T; Hata, J; Ibayashi, S; Kamouchi, M; Kitazono, T; Kusuda, K; Nagao, T; Nakane, H; Omae, T | 1 |
| Anegawa, T; Aoki, Y; Fukuda, K; Fukumoto, Y; Imaizumi, T; Iwamoto, Y; Kai, H; Uchiwa, H; Ueda, T | 1 |
| D'Angelo, A; Dario Ragonesi, P; Derosa, G; Franzetti, I; Maffioli, P; Querci, F | 1 |
| Deng, SB; Du, JL; Liu, YJ; Qiu, B; She, Q; Wang, J | 1 |
| Brown, MJ; Caulfield, M; Cruickshank, JK; Ford, I; MacDonald, TM; Mackenzie, IS; McInnes, G; Morant, S; Salsbury, J; Sever, P; Webb, DJ; Williams, B | 1 |
| Cicero, AF; Tocci, G | 1 |
| Arias, SC; Fanelli, C; Fujihara, CK; Malheiros, DM; Souza, RA; Zatz, R | 1 |
| Kuwabara, JT; Shim, JW; Wainford, RD; Walsh, KR | 1 |
| Ishii, K; Ito, H; Iwakura, K; Kihara, H; Toh, N; Watanabe, H; Yoshikawa, J | 1 |
| Luteijn, JM; Morris, JK; Oppenheimer, P; Taylor, D; Wald, NJ | 1 |
| Luteijn, JM; Morris, JK; Wald, NJ | 1 |
| Gao, C; Lai, C; Li, L; Li, N; Xuan, X | 1 |
| Duran-Salgado, MB; Elizalde-Barrera, CI; Garro-Almendaro, AK; Rubio-Guerra, AF; Suarez-Cuenca, JA | 1 |
| Agarwal, I; Ferket, BS; Fleischmann, KE; Hunink, MG; Khanji, M; Petersen, SE | 1 |
| Matsushima, T; Nakajima, H; Nakajima, K; Ohko, K; Sano, S | 1 |
| Bortolotto, LA; Consolim-Colombo, FM; Costa-Hong, V; Drager, LF; Fatureto-Borges, F; Giorgi, DAM; Jenner, R; Krieger, EM; Lopes, HF; Lorenzi-Filho, G; Marum, E; Teixeira, SH | 1 |
| Chen, X; Li, J; Liu, K; Meng, Q; Shi, D; Shi, R; Wang, S; Zhang, X; Zhou, X | 1 |
| Anegawa, T; Fukuda, K; Fukumoto, Y; Imaizumi, T; Iwamoto, Y; Kai, H; Kajimoto, H; Uchiwa, H | 1 |
| Brown, MJ; Caulfield, M; Cruickshank, JK; Ford, I; MacDonald, TM; Mackenzie, IS; McCann, GP; McInnes, G; Morant, S; Padmanabhan, S; Salsbury, J; Sever, P; Webb, DJ; Williams, B | 1 |
| Abe, J; Fukuda, A; Hasegawa, S; Hatahira, H; Ishiguro, M; Kanoh, H; Kinosada, Y; Motooka, Y; Naganuma, M; Nakamura, M; Nakao, S; Sasaoka, S; Seishima, M; Ueda, N | 1 |
| Absalan, G; Ahmadi, R; Ramezani, AM | 1 |
| de Moura Leão, MF; de Oliveira, LFS; Duarte, JA; Machado, MM; Piccoli, JDCE; Sauzen, PD | 1 |
| Ahn, YK; Chae, SC; Cho, EJ; Cho, MC; Choi, DJ; Chung, WJ; Ha, JW; Hong, SJ; Hong, TJ; Kim, CJ; Kim, SK; Kim, YJ; Lee, HY; Park, CG; Park, S; Shin, J; Sohn, IS; Sung, KC; Yoo, BS; Youn, HJ | 2 |
| Hebibovic, S; Jatic, Z; Rustempasic, E; Skopljak, A; Sukalo, A; Valjevac, A | 1 |
| Blot, WJ; Gonzales, H; Miller, R; Muñoz, D; Munro, H; Pappalardo, S; Reynolds, C; Song, W; Tousey, P; Uzoije, P; Walkley, D; Wang, TJ; White, C | 1 |
| Agabiti-Rosei, C; De Ciuceis, C; Paini, A; Rizzoni, D; Salvetti, M | 1 |
| Abdelsalam, RA; Haddad, GM; Marghany, KA | 1 |
| Ahn, MS; Ahn, SG; Choi, E; Hong, KS; Kim, JY; Lee, JW; Lee, SH; Park, SM; Ryu, DR; Son, JW; Yoo, BS; Yoon, J; Youn, YJ | 1 |
| Aboul-Enein, HY; Ali, I; ALOthman, ZA; Alsheetan, KM | 1 |
| Ahmad, M; Saeed, H; Saleem, Z; Tauqeer, F; Umair, M | 1 |
| Kosman, J; Lenart, VM; Monteiro, JFHL; Tiburtius, ERL; Weinert, PL | 1 |
| Couto, GK; França-Neto, A; Rossoni, LV; Xavier, FE | 1 |
| Khunt, D; Parikh, S; Patel, C; Patel, R; Purohit, S; Solanki, R | 1 |
| Lourenço, FR; Rocha, AL | 1 |
| Liang, H; Tang, T; Xie, M | 1 |
12 review(s) available for losartan and hydrochlorothiazide
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Acute pancreatitis associated with angiotensin II receptor antagonists.
Topics: Acute Disease; Adult; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Diuretics; Drug Combinations; Female; Humans; Hydrochlorothiazide; Irbesartan; Losartan; Pancreatitis; Sodium Chloride Symporter Inhibitors; Tetrazoles | 2002 |
[Angiotensin I receptor antagonist losartan. Part II. Effects in arterial hypertension and diabetic nephropathy].
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diastole; Diuretics; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Irbesartan; Losartan; Meta-Analysis as Topic; Placebos; Prognosis; Randomized Controlled Trials as Topic; Sodium Chloride Symporter Inhibitors; Systole; Tetrazoles; Time Factors; Treatment Outcome; Valine; Valsartan | 2003 |
[Development of combined drugs (ARB and diuretics)].
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Clinical Trials as Topic; Diuretics; Drug Combinations; Drug Design; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Kidney Tubules, Proximal; Losartan; Olmesartan Medoxomil; Practice Guidelines as Topic; Renin-Angiotensin System; Sodium; Telmisartan; Tetrazoles | 2004 |
Comparison of fixed-dose combinations of telmisartan/hydrochlorothiazide 40/12.5 mg and 80/12.5 mg and a fixed-dose combination of losartan/hydrochlorothiazide 50/12.5 mg in mild to moderate essential hypertension: pooled analysis of two multicenter, pros
Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Benzoates; Blood Pressure; Diuretics; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Multicenter Studies as Topic; Prospective Studies; Randomized Controlled Trials as Topic; Telmisartan | 2005 |
Fixed combination of losartan and hydrochlorothiazide and reduction of risk of stroke.
Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Losartan; Risk Factors; Stroke | 2007 |
[Fixed-combination of losartan/hydrochlorothiazide 100 mg/25 mg. Tolerability and efficacy on blood pressure measured in the practice and for 24 hours].
Topics: Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Clinical Trials as Topic; Diastole; Diuretics; Humans; Hydrochlorothiazide; Hypertension; Losartan; Prospective Studies; Systole; Time Factors; Treatment Outcome | 2007 |
Losartan/Hydrochlorothiazide: a review of its use in the treatment of hypertension and for stroke risk reduction in patients with hypertension and left ventricular hypertrophy.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Diuretics; Drug Combinations; Drug Interactions; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Losartan; Risk Reduction Behavior; Stroke; Tissue Distribution | 2009 |
Clinical experience in treating hypertension with fixed-dose combination therapy: angiotensin II receptor blocker losartan plus hydrochlorothiazide.
Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Losartan; Medication Adherence | 2009 |
Combination delapril/manidipine as antihypertensive therapy in high-risk patients.
Topics: Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Clinical Trials as Topic; Diabetes Complications; Dihydropyridines; Drug Combinations; Enalapril; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Indans; Irbesartan; Losartan; Nitrobenzenes; Obesity; Olmesartan Medoxomil; Piperazines; Ramipril; Tetrazoles; Valine; Valsartan | 2011 |
Development and validation of an analytical method for trace-level quantification of genotoxic nitrosamine impurities in losartan and hydrochlorothiazide fixed-dose combination tablets using ultra performance liquid chromatography triple quadrupole mass s
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Humans; Hydrochlorothiazide; Losartan; Nitrosamines; Tablets; Tandem Mass Spectrometry | 2023 |
Efficacy of single-pill combination in uncontrolled essential hypertension: A systematic review and network meta-analysis.
Topics: Amlodipine; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Essential Hypertension; Humans; Hydrochlorothiazide; Hypertension; Irbesartan; Losartan; Network Meta-Analysis; Telmisartan; Tetrazoles; Valine; Valsartan | 2023 |
160 trial(s) available for losartan and hydrochlorothiazide
| Article | Year |
|---|---|
Effects of losartan on the renin-angiotensin-aldosterone axis in essential hypertension.
Topics: Aldosterone; Angiotensin II; Biphenyl Compounds; Blood Pressure; Creatinine; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Renin; Renin-Angiotensin System; Tetrazoles | 1995 |
Effects of losartan on a background of hydrochlorothiazide in patients with hypertension.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Diastole; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Posture; Potassium; Systole; Tetrazoles; Time Factors; Uric Acid | 1995 |
Hemodynamic and humoral effects of the angiotensin II antagonist losartan in essential hypertension.
Topics: Adult; Aldosterone; Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Body Weight; Female; Heart Rate; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Neurotransmitter Agents; Nifedipine; Norepinephrine; Renin; Tetrazoles | 1994 |
Effects of modulators of the renin-angiotensin-aldosterone system on cough. Losartan Cough Study Group.
Topics: Adult; Aged; Angiotensin Receptor Antagonists; Biphenyl Compounds; Cough; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Lisinopril; Losartan; Male; Middle Aged; Prospective Studies; Renin-Angiotensin System; Tetrazoles | 1994 |
Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Asthenia; Atenolol; Biphenyl Compounds; Cough; Dizziness; Double-Blind Method; Fatigue; Felodipine; Female; Headache; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Placebos; Respiratory Tract Infections; Safety; Tetrazoles | 1995 |
Renal hemodynamics in essential hypertensives treated with losartan.
Topics: Antihypertensive Agents; Biphenyl Compounds; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Imidazoles; Kidney; Losartan; Male; Middle Aged; Ramipril; Renal Circulation; Renin-Angiotensin System; Tetrazoles | 1995 |
Association between cough and angiotensin converting enzyme inhibitors versus angiotensin II antagonists: the design of a prospective, controlled study.
Topics: Adult; Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Cough; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Lisinopril; Losartan; Male; Prospective Studies; Research Design; Surveys and Questionnaires; Tetrazoles | 1994 |
Effect of acute and chronic losartan therapy on active and inactive renin and active renin glycoforms.
Topics: Antihypertensive Agents; Biphenyl Compounds; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Isoelectric Focusing; Losartan; Male; Middle Aged; Renin; Renin-Angiotensin System; Tetrazoles | 1995 |
Losartan and low-dose hydrochlorothiazide in patients with essential hypertension. A double-blind, placebo-controlled trial of concomitant administration compared with individual components.
Topics: Adult; Aged; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Double-Blind Method; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Tetrazoles; Treatment Outcome | 1996 |
Losartan potassium as initial therapy in patients with severe hypertension.
Topics: Adolescent; Adult; Aged; Angiotensin Receptor Antagonists; Antihypertensive Agents; Atenolol; Biphenyl Compounds; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Renin-Angiotensin System; Tetrazoles; Treatment Outcome | 1995 |
ACE inhibitors, angiotensin II antagonists and cough. The Losartan Cough Study Group.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Cough; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Lisinopril; Losartan; Male; Middle Aged; Surveys and Questionnaires; Tetrazoles | 1995 |
Absence of a pharmacokinetic interaction between losartan and hydrochlorothiazide.
Topics: Adult; Antihypertensive Agents; Biphenyl Compounds; Cross-Over Studies; Diuretics; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Sodium Chloride Symporter Inhibitors; Tetrazoles | 1995 |
Controlled trial of losartan given concomitantly with different doses of hydrochlorothiazide in hypertensive patients.
Topics: Adult; Antihypertensive Agents; Asthenia; Biphenyl Compounds; Blood Pressure; Controlled Clinical Trials as Topic; Cough; Dizziness; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Headache; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Respiratory Tract Infections; Tetrazoles; Time Factors | 1996 |
[The effectiveness and tolerability of losartan and effect on left ventricular mass in patients with essential hypertension].
Topics: Adult; Aged; Antihypertensive Agents; Diuretics; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Losartan; Male; Middle Aged; Sodium Chloride Symporter Inhibitors | 1998 |
Effects of losartan titrated to losartan/hydrochlorothiazide and amlodipine on blood pressure and peripheral capillary microcirculation in patients with mild-to-moderate hypertension.
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Capillaries; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Microcirculation; Middle Aged | 1998 |
Effects of losartan on hypertension and left ventricular mass: a long-term study.
Topics: Adult; Aged; Antihypertensive Agents; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Losartan; Male; Middle Aged | 1998 |
A study of losartan, alone or with hydrochlorothiazide vs nifedipine GITS in elderly patients with diastolic hypertension.
Topics: Aged; Aging; Antihypertensive Agents; Calcium Channel Blockers; Diastole; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Nifedipine; Treatment Outcome | 1998 |
Comparison of losartan and hydrochlorothiazide on cognitive function and quality of life in hypertensive patients.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Circadian Rhythm; Cognition; Diuretics; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Prognosis; Psychometrics; Quality of Life; Sodium Chloride Symporter Inhibitors; Surveys and Questionnaires | 1999 |
Effects of losartan titrated to Losartan/Hydrochlorothiazide and amlodipine on left ventricular mass in patients with mild-to-moderate hypertension. A double-blind randomized controlled study.
Topics: Adult; Aged; Amlodipine; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Pressure; Body Mass Index; Double-Blind Method; Echocardiography; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Losartan; Male; Middle Aged; Treatment Outcome | 1999 |
Comparison of antihypertensive and metabolic effects of losartan and losartan in combination with hydrochlorothiazide--a randomized controlled trial.
Topics: Antihypertensive Agents; Blood Platelets; Blood Pressure; Diuretics; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Sodium Chloride Symporter Inhibitors; Treatment Outcome; Uric Acid | 2000 |
Comparison of atenolol, amlodipine, enalapril, hydrochlorothiazide, and losartan for antihypertensive treatment in patients with obstructive sleep apnea.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Atenolol; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Cross-Over Studies; Diuretics; Double-Blind Method; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Single-Blind Method; Sleep Apnea, Obstructive; Sodium Chloride Symporter Inhibitors | 2000 |
Fibrinolytic function in diuretic-induced volume depletion.
Topics: Adult; Angiotensin II; Antihypertensive Agents; Blood Volume; Diuretics; Drug Therapy, Combination; Fibrinolysis; Humans; Hydrochlorothiazide; Hypertension, Renal; Losartan; Male; Plasminogen Activator Inhibitor 1; Renin; Sodium Chloride Symporter Inhibitors; Tissue Plasminogen Activator | 2000 |
The efficacy and tolerability of losartan versus atenolol in patients with isolated systolic hypertension. Losartan ISH Investigators Group.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin II; Antihypertensive Agents; Atenolol; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Systole; Treatment Outcome | 2000 |
Long-term effects of losartan and enalapril, alone or with a diuretic, on ambulatory blood pressure and cardiac performance in hypertension: a case-control study.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Carrier Proteins; Case-Control Studies; Diuretics; Drug Synergism; Drug Therapy, Combination; Echocardiography; Enalapril; Female; Follow-Up Studies; Heart Ventricles; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Organic Anion Transporters; Organic Cation Transport Proteins; Sodium Chloride Symporter Inhibitors; Uric Acid; Ventricular Function, Left | 2000 |
Long-term comparison of losartan and enalapril on kidney function in hypertensive type 2 diabetics with early nephropathy.
Topics: Aged; Albuminuria; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diuretics; Double-Blind Method; Drug Therapy, Combination; Enalapril; Female; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Hypertension, Renal; Kidney; Losartan; Male; Middle Aged; Prospective Studies; Sodium Chloride Symporter Inhibitors; Uric Acid | 2000 |
Effects of losartan and candesartan monotherapy and losartan/hydrochlorothiazide combination therapy in patients with mild to moderate hypertension. Losartan Trial Investigators.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Tetrazoles | 2000 |
Efficacy and safety of losartan/hydrochlorothiazide in patients with severe hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diuretics; Drug Therapy, Combination; Felodipine; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Sodium Chloride Symporter Inhibitors; Treatment Outcome | 2001 |
Losartan reduces microalbuminuria in hypertensive microalbuminuric type 2 diabetics.
Topics: Albuminuria; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diastole; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hydrochlorothiazide; Hypertension; Losartan; Regression Analysis; Systole; Uric Acid | 2001 |
Antihypertensive efficacy and safety of losartan alone and in combination with hydrochlorothiazide in adult African Americans with mild to moderate hypertension.
Topics: Antihypertensive Agents; Black or African American; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Treatment Outcome | 2001 |
Losartan titration versus diuretic combination in type 2 diabetic patients.
Topics: Aged; Albuminuria; Antihypertensive Agents; Blood Pressure; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Sodium Chloride Symporter Inhibitors | 2002 |
[Effect of antihypertensive combinations on arterial pressure, albuminuria, and glycemic control in patients with type II diabetic nephropathy: a randomized study].
Topics: Aged; Albuminuria; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Glucose; Blood Pressure; Carbohydrate Metabolism; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diuretics; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hydrochlorothiazide; Hypertension; Indoles; Lipids; Losartan; Male; Middle Aged; Prospective Studies; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Sodium Chloride Symporter Inhibitors; Treatment Outcome; Vasodilator Agents; Verapamil | 2002 |
A multicenter, randomized, double-blind, placebo-controlled, 8-week trial of the efficacy and tolerability of once-daily losartan 100 mg/hydrochlorothiazide 25 mg and losartan 50 mg/hydrochlorothiazide 12.5 mg in the treatment of moderate-to-severe essent
Topics: Adult; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Pulse; Severity of Illness Index; Treatment Outcome | 2002 |
Effects of losartan on cardiovascular morbidity and mortality in patients with isolated systolic hypertension and left ventricular hypertrophy: a Losartan Intervention for Endpoint Reduction (LIFE) substudy.
Topics: Aged; Antihypertensive Agents; Atenolol; Cardiovascular Diseases; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Losartan; Male; Middle Aged; Myocardial Infarction; Proportional Hazards Models; Stroke; Systole; Treatment Outcome | 2002 |
Long-term efficacy and tolerability of telmisartan as monotherapy and in combination with other antihypertensive medications.
Topics: Aged; Antihypertensive Agents; Benzimidazoles; Benzoates; Blood Pressure; Diastole; Diuretics; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Safety; Sodium Chloride Symporter Inhibitors; Systole; Telmisartan | 2002 |
Effect of angiotensin ii receptor blockade on arterial stiffness: beyond blood pressure reduction.
Topics: Aged; Angiotensin II; Antihypertensive Agents; Aorta; Blood Pressure; Brachial Artery; Cross-Over Studies; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Treatment Outcome; Vascular Resistance | 2002 |
ACE inhibition versus angiotensin type 1 receptor antagonism: differential effects on PAI-1 over time.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Glucose; Blood Pressure; Diuretics; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Insulin; Insulin Resistance; Losartan; Male; Middle Aged; Plasminogen Activator Inhibitor 1; Ramipril; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Sodium Chloride Symporter Inhibitors; Tissue Plasminogen Activator; Treatment Outcome | 2002 |
Role of angiotensin II in L-NAME-induced systemic and renal hemodynamic effects in hydrochlorothiazide-pretreated hypertensive subjects.
Topics: Angiotensin II; Antihypertensive Agents; Diuresis; Diuretics; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Glomerular Filtration Rate; Hemodynamics; Hormones; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Natriuresis; NG-Nitroarginine Methyl Ester; Renal Circulation; Sodium Chloride Symporter Inhibitors | 2003 |
Relation of QT interval and QT dispersion to regression of echocardiographic and electrocardiographic left ventricular hypertrophy in hypertensive patients: the Losartan Intervention For Endpoint Reduction (LIFE) study.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Echocardiography; Electrocardiography; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Losartan; Male; Middle Aged; Remission Induction; Single-Blind Method | 2003 |
Efficacy and tolerability of fixed-dose combinations of telmisartan plus HCTZ compared with losartan plus HCTZ in patients with essential hypertension.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Benzoates; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Chi-Square Distribution; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Prospective Studies; Telmisartan | 2003 |
Pharmacokinetics, safety, and antihypertensive efficacy of losartan in combination with hydrochlorothiazide in hypertensive patients with renal impairment.
Topics: Antihypertensive Agents; Area Under Curve; Drug Administration Schedule; Drug Therapy, Combination; Female; Half-Life; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Metabolic Clearance Rate; Middle Aged; Renal Insufficiency; Safety | 2003 |
Telmisartan vs losartan plus hydrochlorothiazide in the treatment of mild-to-moderate essential hypertension--a randomised ABPM study.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Benzoates; Blood Pressure; Blood Pressure Determination; Diuretics; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Severity of Illness Index; Single-Blind Method; Sodium Chloride Symporter Inhibitors; Telmisartan; Treatment Outcome | 2003 |
Central and peripheral hemodynamic effects of losartan and in combination with hydrochlorothiazide in mild to moderate essential hypertension.
Topics: Adult; Analysis of Variance; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cardiac Output; Clinical Protocols; Drug Therapy, Combination; Female; Heart Rate; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Microcirculation; Middle Aged; Moscow; Patient Selection; Sample Size; Time Factors; Treatment Outcome; Vascular Resistance | 2003 |
A comparison of initial treatment with losartan/HCTZ versus losartan monotherapy in chinese patients with mild to moderate essential hypertension.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; China; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Treatment Outcome | 2003 |
Antihypertensive effects of two fixed-dose combinations of losartan and hydrochlorothiazide versus hydrochlorothiazide monotherapy in subjects with ambulatory systolic hypertension.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Outpatients; Treatment Outcome | 2003 |
Comparison of the antihypertensive effects of the fixed dose combination enalapril 10 mg/nitrendipine 20 mg vs losartan 50 mg/hydrochlorothiazide 12.5 mg, assessed by 24-h ambulatory blood pressure monitoring, in essential hypertensive patients.
Topics: Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Double-Blind Method; Drug Combinations; Enalapril; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Nitrendipine; Treatment Outcome | 2004 |
[Efficacy of losartan potassium and its combination with hydrochlorothiazide in hypertensive disease. Focus on the state of microcirculation].
Topics: Adult; Aged; Antihypertensive Agents; Drug Therapy, Combination; Female; Forearm; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Microcirculation; Middle Aged; Treatment Outcome | 2003 |
Effects of losartan versus hydrochlorothiazide on indices of endothelial damage/dysfunction, angiogenesis and tissue factor in essential hypertension.
Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Diuretics; Endothelium, Vascular; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Neovascularization, Pathologic; Sodium Chloride Symporter Inhibitors; Thromboplastin; von Willebrand Factor | 2004 |
The JNC 7 approach compared to conventional treatment in diabetic patients with hypertension: a double-blind trial of initial monotherapy vs. combination therapy.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Chi-Square Distribution; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Ramipril; Treatment Outcome | 2004 |
Combination of losartan and hydrochlorothiazide: in vivo bioequivalence.
Topics: Adolescent; Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Area Under Curve; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Cross-Over Studies; Drug Combinations; Half-Life; Humans; Hydrochlorothiazide; Losartan; Male; Tablets; Therapeutic Equivalency | 2004 |
Combination angiotensin receptor blocker/hydrochlorothiazide as initial therapy in the treatment of patients with severe hypertension.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Prospective Studies; Sodium Chloride Symporter Inhibitors; Treatment Outcome | 2004 |
The effect of losartan and losartan/hydrochlorothiazide fixed-combination on magnesium, zinc, and nitric oxide metabolism in hypertensive patients: a prospective open-label study.
Topics: Antihypertensive Agents; Creatinine; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Magnesium; Male; Middle Aged; Nitric Oxide; Prospective Studies; Zinc | 2005 |
Telmisartan/Hydrochlorothiazide in comparison with losartan/hydrochlorothiazide in managing patients with mild-to-moderate hypertension.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Benzoates; Blood Pressure Monitoring, Ambulatory; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Losartan; Male; Middle Aged; Severity of Illness Index; Telmisartan; Treatment Outcome | 2005 |
Effect of losartan and hydrochlorothiazide on exercise tolerance in exertional hypertension and left ventricular diastolic dysfunction.
Topics: Antihypertensive Agents; Blood Pressure; Diastole; Diuretics; Double-Blind Method; Echocardiography, Doppler; Exercise Tolerance; Female; Follow-Up Studies; Heart Ventricles; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Myocardial Contraction; Physical Exertion; Treatment Outcome; Ventricular Dysfunction, Left | 2006 |
A multicenter, randomized, double-blind, parallel-group trial of the antihypertensive efficacy and tolerability of a combination of once-daily losartan 100 mg/hydrochlorothiazide 12.5 mg compared with losartan 100-mg monotherapy in the treatment of mild t
Topics: Adult; Aged; Antihypertensive Agents; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Losartan; Male; Middle Aged; Treatment Outcome | 2006 |
Blood pressure reduction and antihypertensive medication use in the losartan intervention for endpoint reduction in hypertension (LIFE) study in patients with hypertension and left ventricular hypertrophy.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Atenolol; Blood Pressure; Diastole; Diuretics; Double-Blind Method; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Losartan; Male; Middle Aged; Pulse; Systole; Treatment Outcome | 2007 |
Predictors of antihypertensive drug responses: initial data from a placebo-controlled, randomized, cross-over study with four antihypertensive drugs (The GENRES Study).
Topics: Adrenergic beta-Antagonists; Adult; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Bisoprolol; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Cross-Over Studies; Diuretics; Double-Blind Method; Drug Therapy, Combination; Finland; Genetic Variation; Genotype; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Phenotype; Predictive Value of Tests; Prospective Studies; Reproducibility of Results; Time Factors; Treatment Outcome | 2007 |
Long-term efficacy of combination therapy with losartan and low-dose hydrochlorothiazide in patients with uncontrolled hypertension.
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Tetrazoles; Treatment Outcome | 2007 |
Expedited blood pressure control with initial angiotensin II antagonist/diuretic therapy compared with stepped-care therapy in patients with ambulatory systolic hypertension.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Treatment Outcome | 2007 |
Impact of losartan on stroke risk in hypertensive patients in primary care.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Drug Therapy, Combination; Female; Germany; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Primary Health Care; Risk; Stroke | 2007 |
Association of increased plasma cardiotrophin-1 with inappropriate left ventricular mass in essential hypertension.
Topics: Adult; Aged; Angiotensin II Type 2 Receptor Blockers; Antihypertensive Agents; Atenolol; Biomarkers; Blood Pressure; Cytokines; Diastole; Female; Heart Ventricles; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Losartan; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Systole; Ultrasonography | 2007 |
Antihypertensive efficacy and safety of fixed-dose combination therapy with losartan plus hydrochlorothiazide in Japanese patients with essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Glucose; Blood Pressure; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Japan; Losartan; Male; Middle Aged; Potassium; Uric Acid | 2007 |
Effectiveness of add-on low-dose diuretics in combination therapy for hypertension: losartan/hydrochlorothiazide vs. candesartan/amlodipine.
Topics: Aged; Amlodipine; Antihypertensive Agents; Asian People; Benzimidazoles; Biphenyl Compounds; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Japan; Losartan; Male; Middle Aged; Prospective Studies; Tetrazoles; Treatment Outcome | 2007 |
Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan.
Topics: Adult; Aged; Aldosterone; Antihypertensive Agents; Blood Pressure; Cross-Over Studies; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Lipids; Losartan; Male; Middle Aged; Patient Compliance; Potassium; Proteinuria; Renin; Renin-Angiotensin System; Serum Albumin; Sodium Chloride, Dietary; Uric Acid | 2008 |
Reversal of diuretic-associated impaired glucose tolerance and new-onset diabetes: results of the STAR-LET study.
Topics: Analysis of Variance; Chi-Square Distribution; Diabetes Mellitus; Diuretics; Female; Glucose Tolerance Test; Humans; Hydrochlorothiazide; Hypertension; Indoles; Insulin Resistance; Losartan; Male; Metabolic Syndrome; Middle Aged; Renin-Angiotensin System; Verapamil | 2008 |
Efficacy of manidipine/delapril versus losartan/hydrochlorothiazide fixed combinations in patients with hypertension and diabetes.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Diabetes Complications; Diabetes Mellitus, Type 2; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Indans; Losartan; Male; Middle Aged; Nitrobenzenes; Piperazines; Treatment Outcome | 2008 |
A double-blind, randomized study evaluating losartan potassium monotherapy or in combination with hydrochlorothiazide versus placebo in obese patients with hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Obesity; Time Factors; Treatment Outcome | 2008 |
Laboratory tests as predictors of the antihypertensive effects of amlodipine, bisoprolol, hydrochlorothiazide and losartan in men: results from the randomized, double-blind, crossover GENRES Study.
Topics: Adult; Amlodipine; Antihypertensive Agents; Bisoprolol; Blood Pressure; Calcium; Cross-Over Studies; Double-Blind Method; Forecasting; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Renin; Sodium; Treatment Outcome | 2008 |
[Effects of long-term antihypertensive therapy with losartan on blood pressure and cognitive function in patients with essential hypertension and other cerebrovascular risk factors (AWARE observational study)].
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; C-Reactive Protein; Cerebral Infarction; Dementia; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Long-Term Care; Losartan; Male; Middle Aged; Neuropsychological Tests; Prospective Studies; Risk Factors | 2008 |
Short-term electrophysiological effects of losartan, bisoprolol, amlodipine, and hydrochlorothiazide in hypertensive men.
Topics: Action Potentials; Amlodipine; Antihypertensive Agents; Bisoprolol; Blood Pressure; Cross-Over Studies; Double-Blind Method; Electrocardiography; Electrophysiology; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Time Factors; Treatment Outcome; Ventricular Function | 2009 |
Losartan with hydrochlorothiazide in the treatment of hypertension.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Treatment Outcome; United States | 1995 |
Double-blind comparison of losartan, lisinopril and hydrochlorothiazide in hypertensive patients with a previous angiotensin converting enzyme inhibitor-associated cough.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Cough; Diuretics; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Hypertension; Incidence; Lisinopril; Losartan; Male; Middle Aged; Pain Measurement | 1995 |
Bioequivalence study of two different film-coated tablet formulations of losartan-hydrochlorothiazide in healthy volunteers.
Topics: Adolescent; Adult; Antihypertensive Agents; Area Under Curve; Calibration; Chemistry, Pharmaceutical; Cross-Over Studies; Double-Blind Method; Drug Combinations; Half-Life; Humans; Hydrochlorothiazide; Losartan; Male; Middle Aged; Tablets, Enteric-Coated; Therapeutic Equivalency | 2008 |
Effect of renin-angiotensin-aldosterone system inhibition, dietary sodium restriction, and/or diuretics on urinary kidney injury molecule 1 excretion in nondiabetic proteinuric kidney disease: a post hoc analysis of a randomized controlled trial.
Topics: Acetylglucosaminidase; Adult; Aged; Antihypertensive Agents; Biomarkers; Chronic Disease; Combined Modality Therapy; Cross-Over Studies; Diuretics; Double-Blind Method; Drug Therapy, Combination; Female; Hepatitis A Virus Cellular Receptor 1; Humans; Hydrochlorothiazide; Kidney Diseases; Losartan; Male; Membrane Glycoproteins; Middle Aged; Proteinuria; Receptors, Virus; Renin-Angiotensin System; Sodium, Dietary; Treatment Outcome | 2009 |
Renin-angiotensin system and alpha-adducin gene polymorphisms and their relation to responses to antihypertensive drugs: results from the GENRES study.
Topics: Adult; Amlodipine; Angiotensinogen; Antihypertensive Agents; Bisoprolol; Blood Pressure; Calmodulin-Binding Proteins; Humans; Hydrochlorothiazide; Losartan; Male; Middle Aged; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Receptor, Angiotensin, Type 1; Renin-Angiotensin System | 2009 |
Comparison of therapies between fixed-dose telmisartan/hydrochlorothiazide and losartan/hydrochlorothiazide in patients with mild to moderate hypertension.
Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Benzoates; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cross-Over Studies; Diuretics; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Telmisartan; Treatment Outcome | 2009 |
Effects of high sodium intake and diuretics on the circadian rhythm of blood pressure in type 2 diabetic patients treated with an angiotensin II receptor blocker.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Circadian Rhythm; Diabetes Mellitus, Type 2; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Japan; Losartan; Male; Middle Aged; Prospective Studies; Sodium; Sodium, Dietary; Tetrazoles; Treatment Outcome; Valine; Valsartan | 2009 |
Fixed-dose manidipine/delapril versus losartan/hydrochlorothiazide in hypertensive patients with type 2 diabetes and microalbuminuria.
Topics: Aged; Aged, 80 and over; Albuminuria; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Type 2; Dihydropyridines; Double-Blind Method; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Indans; Losartan; Male; Middle Aged; Nitrobenzenes; Piperazines | 2009 |
Effectiveness of open-label losartan/hydrochlorothiazide combination therapy in Asian patients with hypertension not controlled with ACE inhibitor or ARB monotherapy.
Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Asian People; Blood Pressure; Diuretics; Dose-Response Relationship, Drug; Drug Resistance; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Proteinuria; Young Adult | 2009 |
Antiproteinuric therapy decreases LDL-cholesterol as well as HDL-cholesterol in non-diabetic proteinuric patients: relationships with cholesteryl ester transfer protein mass and adiponectin.
Topics: Adiponectin; Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Cholesterol Ester Transfer Proteins; Cholesterol, HDL; Cholesterol, LDL; Combined Modality Therapy; Coronary Disease; Diet, Sodium-Restricted; Diuretics; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Kidney Diseases; Losartan; Male; Middle Aged; Proteinuria; Risk; Young Adult | 2009 |
A randomized, comparative study evaluating the efficacy and tolerability of losartan-low dose chlorthalidone (6.25 mg) combination with losartan-hydrochlorothiazide (12.5 mg) combination in Indian patients with mild-to-moderate essential hypertension.
Topics: Adolescent; Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Drug Therapy, Combination; Drug Tolerance; Female; Humans; Hydrochlorothiazide; Hypertension; India; Losartan; Male; Middle Aged; Placebos; Treatment Outcome; Young Adult | 2009 |
Renoprotect and blood pressure lowering effect of low-dose hydrochlorothiazide added to intensive renin-angiotensin inhibition in hypertensive patients with chronic kidney disease.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Chronic Disease; Creatinine; Drug Administration Schedule; Drug Combinations; Enalapril; Female; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Hypertension; Kidney Diseases; Losartan; Male; Middle Aged | 2009 |
Antiproteinuric and blood pressure-lowering effects of a fixed-dose combination of losartan and hydrochlorothiazide in hypertensive patients with stage 3 chronic kidney disease.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Chronic Disease; Creatinine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Hypertension; Kidney Diseases; Losartan; Male; Middle Aged; Prospective Studies; Proteinuria; Treatment Outcome | 2009 |
Safety and benefits of a tablet combining losartan and hydrochlorothiazide in Japanese diabetic patients with hypertension.
Topics: Adult; Albuminuria; Aldosterone; Antihypertensive Agents; Asian People; Blood Pressure; Cross-Over Studies; Diabetes Complications; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Natriuretic Peptide, Brain; Renin; Tablets; Treatment Outcome | 2009 |
Simultaneous determination of losartan and hydrochlorothiazide in human plasma by LC/MS/MS with electrospray ionization and its application to pharmacokinetics.
Topics: Administration, Oral; Adult; Chlorthalidone; Chromatography, High Pressure Liquid; Cross-Over Studies; Female; Humans; Hydrochlorothiazide; Losartan; Male; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tetrazoles; Therapeutic Equivalency; Valine; Valsartan | 2009 |
One-year effectiveness and safety of open-label losartan/hydrochlorothiazide combination therapy in Japanese patients with hypertension uncontrolled with ARBs or ACE inhibitors.
Topics: Aged; Antihypertensive Agents; Asian People; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Japan; Losartan; Male; Middle Aged | 2010 |
Comparative vascular and renal tubular effects of angiotensin II receptor blockers combined with a thiazide diuretic in humans.
Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Diuretics; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Imidazoles; Irbesartan; Kidney Tubules; Losartan; Single-Blind Method; Tetrazoles; Valine; Valsartan | 2010 |
A 52-week prospective, cohort study of the effects of losartan with or without hydrochlorothiazide (HCTZ) in hypertensive patients with metabolic syndrome.
Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biomarkers; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Canada; Chi-Square Distribution; Diabetes Mellitus; Diuretics; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hydrochlorothiazide; Hypertension; Linear Models; Losartan; Male; Metabolic Syndrome; Middle Aged; Prospective Studies; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome | 2010 |
Erythropoietin is reduced by combination of diuretic therapy and RAAS blockade in proteinuric renal patients with preserved renal function.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Cross-Over Studies; Diuretics; Double-Blind Method; Drug Therapy, Combination; Erythropoietin; Female; Humans; Hydrochlorothiazide; Kidney; Losartan; Male; Middle Aged; Proteinuria | 2010 |
Ambulatory monitoring of systolic hypertension in the elderly: Eprosartan/hydrochlorothiazide compared with losartan/hydrochlorothiazide (INSIST trial).
Topics: Acrylates; Aged; Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Diuretics; Double-Blind Method; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Losartan; Male; Office Visits; Severity of Illness Index; Statistics, Nonparametric; Systole; Thiophenes; Treatment Outcome | 2010 |
Fixed-dose telmisartan/hydrochlorothiazide in comparison with losartan/hydrochlorothiazide in decreasing serum hepatocyte growth factor and improving endothelial dysfunction in hypertensive patients.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Benzoates; Biomarkers; Cohort Studies; Drug Combinations; Endothelins; Endothelium, Vascular; Female; Hepatocyte Growth Factor; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Nitric Oxide; Telmisartan | 2010 |
How to avoid discontinuation of antihypertensive treatment: The experience in São Paulo, Brazil.
Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Clinical Protocols; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Medication Adherence; Middle Aged; Telephone | 2010 |
Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 2: clinical studies.
Topics: Androstanols; Antihypertensive Agents; Blood Pressure; Calmodulin-Binding Proteins; Female; Genetic Loci; Humans; Hydrochlorothiazide; Hypertension; Intramolecular Transferases; Kidney; Losartan; Male; Middle Aged; Mutant Proteins; Ouabain; Placebos; Polymorphism, Single Nucleotide; Systole; Time Factors; Transfection | 2010 |
Effects of losartan/hydrochlorothiazide treatment, after change from ARB at usual dosage, on blood pressure and various metabolic parameters including high-molecular weight adiponectin in Japanese male hypertensive subjects.
Topics: Adiponectin; Aged; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Glucose; Blood Pressure; Creatinine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hydrochlorothiazide; Hypertension; Lipids; Losartan; Male; Middle Aged; Treatment Outcome | 2011 |
Switching therapy from variable-dose multiple pill to fixed-dose single-pill combinations of angiotensin II receptor blockers and thiazides for hypertension.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Japan; Losartan; Male; Medication Adherence; Middle Aged; Patient Satisfaction; Sodium Chloride Symporter Inhibitors | 2011 |
Effects of antiproteinuric intervention on elevated connective tissue growth factor (CTGF/CCN-2) plasma and urine levels in nondiabetic nephropathy.
Topics: Angiotensin II Type 1 Receptor Blockers; Biomarkers; Chronic Disease; Combined Modality Therapy; Connective Tissue Growth Factor; Cross-Over Studies; Diet, Sodium-Restricted; Diuretics; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Kidney Diseases; Losartan; Male; Middle Aged; Netherlands; Proteinuria; Time Factors; Treatment Outcome; Up-Regulation | 2011 |
Combination of angiotensin II receptor antagonist with calcium channel blocker or diuretic as antihypertensive therapy for patients with chronic kidney disease.
Topics: Aged; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cross-Over Studies; Diuretics; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Hypertension; Kidney Failure, Chronic; Losartan; Male; Middle Aged; Nifedipine; Treatment Outcome | 2011 |
Combination angiotensin-receptor blocker (ARB)/calcium channel blocker with HCTZ vs the maximal recommended dose of an ARB with HCTZ in patients with stage 2 hypertension: the exforge as compared to losartan treatment in stage 2 systolic hypertension (EXA
Topics: Amlodipine; Angiotensin Receptor Antagonists; Blood Pressure; Calcium Channel Blockers; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Severity of Illness Index; Tetrazoles; Treatment Outcome; United States; Valine; Valsartan | 2011 |
Plasma fibrin clot properties in arterial hypertension and their modification by antihypertensive medication.
Topics: Adult; Amlodipine; Antihypertensive Agents; Bisoprolol; Blood Coagulation; Female; Fibrin; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Quinapril; Tetrahydroisoquinolines | 2012 |
To study the efficacy of Losartan on urinary uric acid excretion in Thiazide induced hyperuricemic and hypertensive patients.
Topics: Aged; Humans; Hydrochlorothiazide; Hypertension; Hyperuricemia; Kidney; Losartan; Middle Aged; Sodium Chloride Symporter Inhibitors; Treatment Outcome; Uric Acid; Uricosuric Agents | 2011 |
Adding thiazide to a renin-angiotensin blocker improves left ventricular relaxation and improves heart failure in patients with hypertension.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Female; Heart Failure; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Prospective Studies; Sodium Chloride Symporter Inhibitors; Treatment Outcome; Ventricular Dysfunction, Left | 2012 |
Effects of losartan/hydrochlorothiazide on serum uric acid levels and blood pressure in hypertensive patients.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Female; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Uric Acid | 2011 |
Ambulatory blood pressure response to triple therapy with an angiotensin-receptor blocker (ARB), calcium-channel blocker (CCB), and HCTZ versus dual therapy with an ARB and HCTZ.
Topics: Amlodipine; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Tetrazoles; Valine; Valsartan | 2011 |
Antihypertensive efficacy of the losartan/hydrochlorothiazide combination and its effect on plasma B-type natriuretic peptide in hypertensive patients uncontrolled by angiotensin II type 1 receptor antagonist-based therapy: a multicentre prospective obser
Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Natriuretic Peptide, Brain; Prospective Studies | 2012 |
The relationship of electrocardiographic left ventricular hypertrophy to decreased serum potassium.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Hypokalemia; Losartan; Male; Prospective Studies; Ultrasonography | 2012 |
Efficacy and safety of early versus late titration of fixed-dose irbesartan/hydrochlorothiazide: ACTUAL study.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Prospective Studies | 2011 |
Losartan/hydrochlorothiazide combination vs. high-dose losartan in patients with morning hypertension--a prospective, randomized, open-labeled, parallel-group, multicenter trial.
Topics: Aged; Aged, 80 and over; Albuminuria; Antihypertensive Agents; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Uric Acid | 2012 |
Does a combination pill of antihypertensive drugs improve medication adherence in Japanese? A randomized controlled trial.
Topics: Administration, Oral; Aged; Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Asian People; Blood Pressure; Chi-Square Distribution; Diuretics; Drug Combinations; Female; Health Knowledge, Attitudes, Practice; Humans; Hydrochlorothiazide; Hypertension; Japan; Linear Models; Losartan; Male; Medication Adherence; Middle Aged; Tablets; Time Factors; Treatment Outcome | 2012 |
Long-term antihypertensive efficacy of losartan/hydrochlorothiazide combination therapy on home blood pressure control.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Time Factors; Treatment Outcome; Young Adult | 2012 |
Three-year safety and effectiveness of fixed-dose losartan/hydrochlorothiazide combination therapy in Japanese patients with hypertension under clinical setting (PALM-1 Extension Study).
Topics: Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Asian People; Blood Pressure; Diuretics; Drug Combinations; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Treatment Outcome | 2012 |
The velocity of antihypertensive effect of losartan/hydrochlorothiazide and angiotensin II receptor blocker.
Topics: Aged; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Pressure; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged | 2012 |
Change in high-sensitive cardiac troponin T on hypertensive treatment.
Topics: Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biomarkers; Blood Pressure; Calcium Channel Blockers; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Natriuretic Peptide, Brain; Troponin T | 2013 |
Efficacy and safety of the losartan-hydrochlorothiazide combination tablet in patients with hypertension uncontrolled by angiotensin II receptor antagonist therapy: the Aichi Research on Combination therapy for Hypertension (ARCH) Study.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Japan; Losartan; Male; Middle Aged; Prospective Studies; Treatment Outcome | 2012 |
Efficacy and effect on plasma B-type natriuretic peptide concentration of losartan-hydrochlorothiazide for hypertension uncontrolled by losartan-based therapy: subanalysis of a Multicentre Prospective Observational Study.
Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Diuretics; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Natriuretic Peptide, Brain; Prospective Studies; Uric Acid | 2012 |
Comparison of medium-dose losartan/hydrochlorothiazide and maximal-dose angiotensin II receptor blockers in the treatment of Japanese patients with uncontrolled hypertension: the Kobe-CONNECT Study.
Topics: Aged; Angiotensin Receptor Antagonists; Antihypertensive Agents; Asian People; Blood Pressure; Circadian Rhythm; Diuretics; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Japan; Losartan; Male; Middle Aged; Prospective Studies; Treatment Outcome | 2012 |
Randomized Polypill crossover trial in people aged 50 and over.
Topics: Aged; Amlodipine; Anticholesteremic Agents; Antihypertensive Agents; Blood Pressure; Cardiovascular Diseases; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypercholesterolemia; Hypertension; Losartan; Male; Middle Aged; Placebos; Simvastatin | 2012 |
[Series: Clinical study from Japan and its reflections morning hypertension and angiotensin receptor blocker/hydrochlorothiazide combination therapy study--MAPPY study].
Topics: Aged; Angiotensin Receptor Antagonists; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Prospective Studies; Time | 2012 |
Effects of combined antihypertensive therapy with losartan/hydrochlorothiazide on uric acid metabolism.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Creatinine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Multivariate Analysis; Treatment Outcome; Uric Acid | 2012 |
[Effectiveness and safety of losartan and its combination with hydrochlorothiazide in patients with hypertension: in result study].
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Diuretics; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Retrospective Studies; Treatment Outcome | 2012 |
Losartan/hydrochlorothiazide combination therapy surpasses high-dose angiotensin receptor blocker in the reduction of morning home blood pressure in patients with morning hypertension.
Topics: Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Prospective Studies; Treatment Outcome | 2012 |
Comparison of the effect of combination therapy with an angiotensin II receptor blocker and either a low-dose diuretic or calcium channel blocker on cardiac hypertrophy in patients with hypertension.
Topics: Aged; Angiotensin Receptor Antagonists; Blood Pressure; Calcium Channel Blockers; Diuretics; Drug Therapy, Combination; Echocardiography; Female; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Losartan; Male; Middle Aged; Treatment Outcome | 2013 |
Low-grade inflammation and ambulatory blood pressure response to antihypertensive treatment: the ALPHABET study.
Topics: Amlodipine; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Dose-Response Relationship, Drug; Drug Combinations; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Inflammation; Losartan; Male; Middle Aged; Treatment Outcome | 2013 |
Reduction in morning blood pressure is a key factor for ameliorating urinary albumin excretion in patients with morning hypertension irrespective of treatment regimen.
Topics: Aged; Aged, 80 and over; Albuminuria; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Middle Aged; Time Factors | 2013 |
Efficacy and effects on lipid metabolism of combination treatment with losartan + hydrochlorothiazide versus losartan + amlodipine: a 48-week prospective, multicenter, randomized, open-label trial.
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Lipid Metabolism; Losartan; Male; Middle Aged; Prospective Studies | 2013 |
Combination of antihypertensive therapy in the elderly, multicenter investigation (CAMUI) trial: results after 1 year.
Topics: Aged; Aged, 80 and over; Amlodipine; Angiotensin Receptor Antagonists; Antihypertensive Agents; Calcium Channel Blockers; Cognition; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male | 2013 |
Which is a better treatment for hypertensive patients with diabetes: a combination of losartan and hydrochlorothiazide or a maximum dose of losartan?
Topics: Aged; Albuminuria; Antihypertensive Agents; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Hyperuricemia; Losartan; Male; Middle Aged; Renal Insufficiency, Chronic; Treatment Outcome; Uric Acid | 2013 |
In-treatment HDL cholesterol levels and development of new diabetes mellitus in hypertensive patients: the LIFE Study.
Topics: Aged; Antihypertensive Agents; Atenolol; Cholesterol, HDL; Comorbidity; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperglycemia; Hypertension; Hypertrophy, Left Ventricular; Incidence; Losartan; Male; Middle Aged; Predictive Value of Tests; Proportional Hazards Models; Risk Factors | 2013 |
Angiotensin receptor blocker (ARB)-diuretic versus ARB-calcium channel blocker combination therapy for hypertension uncontrolled by ARB monotherapy.
Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Calcium Channel Blockers; Diuretics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Prospective Studies; Time Factors; Treatment Outcome; Uric Acid; Young Adult | 2014 |
A comparative study on the effectiveness of losartan/hydrochlorothiazide and telmisartan/hydrochlorothiazide in patients with hypertension.
Topics: Adult; Aged; Benzimidazoles; Benzoates; Blood Pressure; Dose-Response Relationship, Drug; Drug Combinations; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Prospective Studies; Telmisartan; Treatment Outcome; Uric Acid | 2014 |
Anti-hypertensive strategies in patients with MEtabolic parameters, DIabetes mellitus and/or NephropAthy (the M E D I N A study).
Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Diseases; Losartan; Male; Metabolic Syndrome; Middle Aged; Risk Factors; Single-Blind Method | 2014 |
Comparative effectiveness of a fixed-dose combination of losartan + HCTZ versus bisoprolol + HCTZ in patients with moderate-to-severe hypertension: results of the 6-month ELIZA trial.
Topics: Adrenergic beta-1 Receptor Antagonists; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Bisoprolol; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Chi-Square Distribution; Diuretics; Doxazosin; Drug Combinations; Drug Therapy, Combination; Electrocardiography; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Pulse Wave Analysis; Severity of Illness Index; Time Factors; Treatment Outcome; Ukraine; Vascular Stiffness | 2013 |
Pharmacokinetic comparison and bioequivalence evaluation of losartan/ hydrochlorothiazide tablet between Asian Indian and Japanese volunteers.
Topics: Adolescent; Adult; Asian People; Biological Availability; Cross-Over Studies; Drug Combinations; Female; Healthy Volunteers; Humans; Hydrochlorothiazide; India; Losartan; Male; Middle Aged; Tablets; Tandem Mass Spectrometry; Therapeutic Equivalency | 2014 |
[Possibilities of rational combination antihypertensive therapy: results of HEMERA international clinical trial].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Blood Pressure; Diuretics; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Prospective Studies; Ramipril; Treatment Outcome; Young Adult | 2013 |
Type 2 diabetes mellitus complicated by hypertension in Japanese patients: switching treatment from high-dose angiotensin II receptor blockers to losartan plus hydrochlorothiazide.
Topics: Aged; Angiotensin Receptor Antagonists; Antihypertensive Agents; Diabetes Mellitus, Type 2; Drug Combinations; Drug Substitution; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Japan; Losartan; Male; Middle Aged; Treatment Outcome | 2014 |
Impact of combined losartan/hydrochlorothiazide on proteinuria in patients with chronic kidney disease and hypertension.
Topics: Adult; Aged; Creatinine; Diuretics; Drug Combinations; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Prospective Studies; Proteinuria; Renal Insufficiency, Chronic; Treatment Outcome; Uric Acid; Young Adult | 2014 |
Efficacy and safety of losartan 100 mg/hydrochlorothiazide 12.5 mg in Japanese subjects with essential hypertension: two randomized, controlled trials.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Asian People; Diuretics; Double-Blind Method; Drug Combinations; Endpoint Determination; Essential Hypertension; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Patient Safety; Young Adult | 2014 |
Effect of losartan on serum uric acid in hypertension treated with a diuretic: the COMFORT study.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Diuretics; Drug Combinations; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Treatment Outcome; Uric Acid | 2015 |
Efficacy and safety of combination therapy of high-dose losartan and hydrochlorothiazide in patients with hypertension.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Creatinine; Diastole; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glycated Hemoglobin; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Potassium; Systole; Treatment Outcome; Uric Acid | 2015 |
Efficacy and tolerability of amlodipine camsylate/losartan 5/100-mg versus losartan/hydrochlorothiazide 100/12.5-mg fixed-dose combination in hypertensive patients nonresponsive to losartan 100-mg monotherapy.
Topics: Adult; Amlodipine; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Treatment Outcome | 2014 |
Efficacy and safety of fixed-dose losartan/hydrochlorothiazide/amlodipine combination versus losartan/hydrochlorothiazide combination in Japanese patients with essential hypertension.
Topics: Aged; Amlodipine; Antihypertensive Agents; Blood Pressure; Drug Combinations; Drug Monitoring; Essential Hypertension; Female; Humans; Hydrochlorothiazide; Hypertension; Japan; Losartan; Male; Middle Aged; Treatment Outcome | 2015 |
Differential effects of angiotensin II receptor blocker and losartan/hydrochlorothiazide combination on central blood pressure and augmentation index.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Treatment Outcome; Young Adult | 2015 |
Regression of Electrocardiographic Signs of Left Ventricular Hypertrophy by Combined Treatment With Thiazide Diuretic and Angiotensin-II Receptor Blocker.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Drug Therapy, Combination; Electrocardiography; Humans; Hydrochlorothiazide; Hypertrophy, Left Ventricular; Losartan; Male; Middle Aged; Natriuretic Peptide, Brain | 2014 |
Fixed-dose combination of losartan and hydrochlorothiazide significantly improves endothelial function in uncontrolled hypertension by low-dose amlodipine: a randomized study.
Topics: Aged; Amlodipine; Antihypertensive Agents; Brachial Artery; Drug Therapy, Combination; Endothelium, Vascular; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Pulsatile Flow; Treatment Outcome | 2014 |
Pharmacogenomics of hypertension: a genome‐wide, placebo‐controlled cross‐over study, using four classes of antihypertensive drugs.
Topics: Adult; Aldehyde Oxidoreductases; Amlodipine; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Bisoprolol; Blood Pressure Monitoring, Ambulatory; Chloride Channels; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Essential Hypertension; Finland; Genome-Wide Association Study; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Membrane Proteins; Meta-Analysis as Topic; Microfilament Proteins; Middle Aged; Mutation, Missense; Pharmacogenetics; Polymorphism, Single Nucleotide; Severity of Illness Index; Tetrazoles; Treatment Outcome | 2015 |
Prospective randomized study of the tolerability and efficacy of combination therapy for hypertensive chronic kidney disease: results of the PROTECT-CKD study.
Topics: Adult; Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diuretics; Drug Therapy, Combination; Enalapril; Female; Humans; Hydrochlorothiazide; Hypertension, Renal; Losartan; Male; Middle Aged; Prospective Studies; Renal Insufficiency, Chronic; Young Adult | 2015 |
TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives.
Topics: Adult; Aged; Aldosterone; Antihypertensive Agents; Blood Pressure; Case-Control Studies; Dioxygenases; DNA-Binding Proteins; Essential Hypertension; Genome-Wide Association Study; Humans; Hydrochlorothiazide; Hypertension; Italy; Losartan; Male; Membrane Proteins; Middle Aged; Pharmacogenetics; Proto-Oncogene Proteins; Sodium Chloride Symporter Inhibitors; Systole; Tumor Suppressor Proteins; White People | 2015 |
Add-on effect of hydrochlorothiazide 12.5 mg in Japanese subjects with essential hypertension uncontrolled with losartan 50 mg and amlodipine 5 mg.
Topics: Adult; Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Essential Hypertension; Female; Humans; Hydrochlorothiazide; Hypertension; Japan; Losartan; Male; Middle Aged; Single-Blind Method; Treatment Outcome; Young Adult | 2015 |
Effects of hydrochlorothiazide on oxidative stress and pulse pressure in hypertensive patients with chronic stroke: the EMINENT study.
Topics: Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Chronic Disease; Female; Glycated Hemoglobin; Humans; Hydrochlorothiazide; Hypertension; Lipoproteins, LDL; Losartan; Male; Middle Aged; Oxidative Stress; Stroke | 2015 |
Benefit of losartan/hydrochlorothiazide-fixed dose combination treatment for isolated morning hypertension: The MAPPY study.
Topics: Aged; Blood Pressure; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Prospective Studies; Treatment Outcome | 2015 |
Visit-to-visit variability and seasonal variation in blood pressure: Combination of Antihypertensive Therapy in the Elderly, Multicenter Investigation (CAMUI) Trial subanalysis.
Topics: Aged; Amlodipine; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Prospective Studies; Seasons; Treatment Outcome | 2015 |
Comparison of the effects of barnidipine+losartan compared with telmisartan+hydrochlorothiazide on several parameters of insulin sensitivity in patients with hypertension and type 2 diabetes mellitus.
Topics: Adipokines; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Benzoates; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Diuretics; Double-Blind Method; Drug Combinations; Female; Glucose Clamp Technique; Humans; Hydrochlorothiazide; Hypertension; Insulin Resistance; Losartan; Male; Middle Aged; Nifedipine; Telmisartan | 2015 |
The effects of a low-salt diet on the efficacy of different antihypertensive drug regimens.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Diet, Sodium-Restricted; Drug Synergism; Drug Therapy, Combination; Essential Hypertension; Female; Humans; Hydrochlorothiazide; Hypertension; Irbesartan; Losartan; Male; Middle Aged; Tetrazoles; Young Adult | 2015 |
Monotherapy versus dual therapy for the initial treatment of hypertension (PATHWAY-1): a randomised double-blind controlled trial.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Double-Blind Method; Drug Therapy, Combination; Essential Hypertension; Female; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Medication Adherence; Middle Aged; Prospective Studies; Young Adult | 2015 |
Effect of Diuretic or Calcium-Channel Blocker Plus Angiotensin-Receptor Blocker on Diastolic Function in Hypertensive Patients.
Topics: Adult; Aged; Aged, 80 and over; Amlodipine; Angiotensin Receptor Antagonists; Blood Pressure; Calcium Channel Blockers; Diastole; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Prospective Studies; Ventricular Dysfunction, Left | 2016 |
Effect of losartan combined with amlodipine or with a thiazide on uric acid levels in hypertensive patients.
Topics: Amlodipine; Antihypertensive Agents; Biomarkers; Blood Pressure; Dose-Response Relationship, Drug; Drug Combinations; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Time Factors; Treatment Outcome; Uric Acid | 2017 |
Comparison between the effects of hydrochlorothiazide and indapamide on the kidney in hypertensive patients inadequately controlled with losartan.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Creatinine; Female; Humans; Hydrochlorothiazide; Hypertension; Indapamide; Kidney; Lipocalin-2; Losartan; Male; Middle Aged; Prospective Studies; Treatment Failure | 2017 |
Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial.
Topics: Adolescent; Adult; Aged; Amlodipine; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Doxazosin; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Treatment Outcome; Young Adult | 2017 |
Comparison of 24-Hour Ambulatory Central Blood Pressure Reduction Efficacy Between Fixed Amlodipine or Up-Titrated Hydrochlorothiazide Plus Losartan: The K-Central Study.
Topics: Aged; Amlodipine; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Double-Blind Method; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Prospective Studies; Republic of Korea; Time Factors; Treatment Outcome | 2019 |
The association of smoothness index of central blood pressure with ambulatory carotid femoral pulse wave velocity after 20-week treatment with losartan in combination with amlodipine versus hydrochlorothiazide.
Topics: Aged; Amlodipine; Antihypertensive Agents; Blood Pressure; Carotid-Femoral Pulse Wave Velocity; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged | 2019 |
Polypill for Cardiovascular Disease Prevention in an Underserved Population.
Topics: Adult; Alabama; Amlodipine; Antihypertensive Agents; Atorvastatin; Cholesterol, LDL; Community Health Centers; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Losartan; Male; Medically Underserved Area; Medication Adherence; Middle Aged | 2019 |
Comparison of Blood Pressure Variability Between Losartan and Amlodipine in Essential Hypertension (COMPAS-BPV).
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Essential Hypertension; Female; Humans; Hydrochlorothiazide; Losartan; Male; Middle Aged | 2020 |
129 other study(ies) available for losartan and hydrochlorothiazide
| Article | Year |
|---|---|
Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3).
Topics: Amino Acid Sequence; Animals; Anion Transport Proteins; Biological Transport; Blotting, Northern; Carrier Proteins; Chromosomes, Human, Pair 11; Cloning, Molecular; Humans; Kidney; Mice; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Sequence Homology, Amino Acid; Xenopus laevis | 1999 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Regulation of glomerular TGF-beta expression in the contralateral kidney of two-kidney, one-clip hypertensive rats.
Topics: Animals; Antihypertensive Agents; Drug Combinations; Hydralazine; Hydrochlorothiazide; Hypertension, Renovascular; Kidney; Kidney Glomerulus; Losartan; Male; Rats; Rats, Wistar; Reserpine; RNA, Messenger; Sclerosis; Time Factors; Transforming Growth Factor beta | 1998 |
Telemetry for cardiovascular monitoring in a pharmacological study: new approaches to data analysis.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Cardiomegaly; Cell Nucleus; Diastole; DNA; Female; Heart Rate; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Indoles; Losartan; Lymphocytes; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Perindopril; Rats; Rats, Inbred SHR; Systole; Telemetry; Time Factors | 1999 |
Key features of candesartan cilexetil and a comparison with other angiotensin II receptor antagonists.
Topics: Amlodipine; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Delayed-Action Preparations; Diuretics; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Losartan; Renin-Angiotensin System; Retrospective Studies; Sodium Chloride Symporter Inhibitors; Tetrazoles; Treatment Outcome | 1999 |
[Antihypertensive efficacy of monotherapy in increasing doses versus therapy associated in low doses].
Topics: Antihypertensive Agents; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Losartan; Middle Aged | 1999 |
Simultaneous determination of losartan and hydrochlorothiazide in tablets by high-performance liquid chromatography.
Topics: Antihypertensive Agents; Calibration; Chromatography, High Pressure Liquid; Diuretics; Hydrochlorothiazide; Losartan; Reproducibility of Results; Sensitivity and Specificity; Sodium Chloride Symporter Inhibitors; Spectrophotometry, Ultraviolet | 2000 |
Analysis of binary mixtures of losartan potassium and hydrochlorothiazide by using high performance liquid chromatography, ratio derivative spectrophotometric and compensation technique.
Topics: Chromatography, High Pressure Liquid; Hydrochlorothiazide; Losartan; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry; Tablets | 2001 |
The influence of chronic antihypertensive treatment on the central pressor response in SHR.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Body Weight; Brain; Enalapril; Epinephrine; Heart Rate; Hydralazine; Hydrochlorothiazide; Hypertension; Injections, Intraventricular; Losartan; Male; Norepinephrine; Peptidyl-Dipeptidase A; Rats; Rats, Inbred SHR; Saline Solution, Hypertonic; Tetrazoles | 2001 |
Chronic administration of losartan plus hydrochlorothiazide improves vascular status in young cardiomyopathic hamsters.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Aorta, Thoracic; Body Weight; Cardiomyopathies; Cricetinae; Dose-Response Relationship, Drug; Drug Synergism; Endothelin-1; Endothelium, Vascular; Hydrochlorothiazide; In Vitro Techniques; Losartan; Male; Mesocricetus; Myocardium; Nitric Oxide; Organ Size; Peptidyl-Dipeptidase A; Vasoconstriction; Vasodilation; Vasodilator Agents | 2001 |
Remission achieved in chronic nephropathy by a multidrug approach targeted at urinary protein excretion.
Topics: Adult; Algorithms; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Diuretics; Drug Therapy, Combination; Enalapril; Female; Humans; Hydrochlorothiazide; Kidney Diseases; Kidney Failure, Chronic; Losartan; Lupus Nephritis; Proteinuria; Sodium Chloride Symporter Inhibitors | 2001 |
Effects of losartan/diuretic combination treatment on serum uric acid levels in hypertensive patients.
Topics: Antihypertensive Agents; Diuretics; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Losartan; Sodium Chloride Symporter Inhibitors; Uric Acid | 2001 |
The potential economic consequences of cognitive improvement with losartan.
Topics: Adult; Aged; Antihypertensive Agents; Cognition; Cognition Disorders; Cost-Benefit Analysis; Female; Humans; Hydrochlorothiazide; Intelligence Tests; Losartan; Male; Middle Aged; Sweden | 2002 |
[Efficacy and safety of combination therapy with losartan and hydrochlorothiazide in elderly hypertension].
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Diuretics; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Sodium Chloride Symporter Inhibitors | 2002 |
Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism.
Topics: Administration, Oral; Allopurinol; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arterioles; Benzofurans; Blood Pressure; Diuretics; Enalapril; Hydrochlorothiazide; Hypertension; Kidney; Losartan; Male; Muscle, Smooth, Vascular; Oxonic Acid; Rats; Rats, Sprague-Dawley; Sodium Chloride Symporter Inhibitors; Sodium Chloride, Dietary; Uric Acid; Uricosuric Agents; Vascular Diseases | 2002 |
Trough-to-peak ratio, smoothness index, and circadian blood pressure profile after treatment with once-daily fixed combination of losartan 100 and hydrochlorothiazide 25 in essential hypertension.
Topics: Adult; Aged; Analysis of Variance; Blood Pressure; Blood Pressure Determination; Circadian Rhythm; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged | 2002 |
Determination of losartan and hydrochlorothiazide in tablets by CE and CEC.
Topics: Antihypertensive Agents; Chromatography, High Pressure Liquid; Electrophoresis, Capillary; Hydrochlorothiazide; Indicators and Reagents; Losartan; Tablets | 2002 |
Development and validation of a stability-indicating HPLC method for the simultaneous determination of losartan potassium, hydrochlorothiazide, and their degradation products.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Hydrochlorothiazide; Losartan | 2002 |
Persistent lowering of arterial pressure after continuous and intermittent therapy.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Enalapril; Heart Rate; Heart Ventricles; Hydralazine; Hydrochlorothiazide; Hypertension; Losartan; Male; Nifedipine; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Vasodilator Agents | 2003 |
[Hemodynamics and cell membrane effects of angiotensin II receptor antagonists in treatment of hypertension].
Topics: Adenosine Triphosphatases; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Platelets; Calcium; Erythrocytes; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Losartan; Membrane Potentials; Membrane Proteins; Middle Aged; Peptidyl-Dipeptidase A | 2003 |
[LIFE study proves preventive action. With losartan to do even more against stroke].
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Diabetes Complications; Double-Blind Method; Electrocardiography; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Losartan; Middle Aged; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Time Factors | 2003 |
LIFE: losartan versus atenolol.
Topics: Antihypertensive Agents; Atenolol; Comorbidity; Death, Sudden, Cardiac; Diabetes Mellitus; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Losartan; Randomized Controlled Trials as Topic; Treatment Outcome | 2003 |
[Therapy of patients with arterial hypertension with fixed dose combination of losartan and hydrochlorothiazide. Effect on 24 hour blood pressure and left-ventricular hypertrophy].
Topics: Adult; Aged; Antihypertensive Agents; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Losartan; Magnetic Resonance Imaging; Male; Middle Aged; Sodium Chloride Symporter Inhibitors; Treatment Outcome | 2003 |
Tight blood pressure control decreases apoptosis during renal damage.
Topics: Animals; Antihypertensive Agents; Apoptosis; Blood Pressure; Cell Division; Drug Therapy, Combination; Hydralazine; Hydrochlorothiazide; Hypertension, Renal; Immunohistochemistry; Losartan; Male; Proteinuria; Quinapril; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reserpine; Tetrahydroisoquinolines | 2004 |
[AT-1 blockers are different in their effects. The forgetful patients begin to notice it especially].
Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Diuretics; Double-Blind Method; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Losartan; Meta-Analysis as Topic; Placebos; Randomized Controlled Trials as Topic; Sodium Chloride Symporter Inhibitors; Stroke; Tetrazoles; Time Factors; Valine; Valsartan | 2003 |
Cardioprotective effects of vasopeptidase inhibition vs. angiotensin type 1-receptor blockade in spontaneously hypertensive rats on a high salt diet.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Apoptosis; Autoradiography; Body Weight; Cardiotonic Agents; Connective Tissue Growth Factor; Fibrosis; Hydrochlorothiazide; Hypertension; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Losartan; Male; Myocardium; Organ Size; Protease Inhibitors; Pyridines; Rats; Rats, Inbred SHR; Renin; Sodium Chloride, Dietary; Thiazepines | 2004 |
Stability study of losartan/hydrochlorothiazide tablets.
Topics: Drug Combinations; Drug Contamination; Drug Packaging; Drug Stability; Hydrochlorothiazide; Losartan; Molecular Structure; Tablets; Time Factors | 2005 |
Persistent sympathetic activation during chronic antihypertensive therapy: a potential mechanism for long term morbidity?
Topics: Adult; Antihypertensive Agents; Baroreflex; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cardiovascular System; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Muscle, Skeletal; Posture; Rest; Supine Position; Sympathetic Nervous System; Time Factors | 2005 |
Superiority of combination of thiazide with angiotensin-converting enzyme inhibitor or AT1-receptor blocker over thiazide alone on renoprotection in L-NAME/SHR.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Body Weight; Diuretics; Enalapril; Enzyme Inhibitors; Hematocrit; Hemodynamics; Hydrochlorothiazide; Kidney; Kidney Diseases; Kidney Glomerulus; Losartan; Male; NG-Nitroarginine Methyl Ester; Organ Size; Rats; Rats, Inbred SHR; Renal Circulation; Vascular Resistance | 2005 |
Antihypertensive treatment and sympathetic excitation.
Topics: Antihypertensive Agents; Baroreflex; Blood Pressure; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Losartan; Muscle, Skeletal; Sympathetic Nervous System | 2005 |
Blockade of angiotensin II provides additional benefits in hypertension- and ageing-related cardiac and vascular dysfunctions beyond its blood pressure-lowering effects.
Topics: Aging; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Coronary Vessels; Hydralazine; Hydrochlorothiazide; Hypertension; In Vitro Techniques; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium Chloride Symporter Inhibitors; Vasodilation; Vasodilator Agents | 2005 |
Impact of antihypertensive treatments on erectile responses in aging spontaneously hypertensive rats.
Topics: Aging; Animals; Antihypertensive Agents; Apomorphine; Blood Pressure; Enalapril; Hydralazine; Hydrochlorothiazide; Hypertension; Kidney Transplantation; Losartan; Male; Nifedipine; Penile Erection; Random Allocation; Rats; Rats, Inbred SHR; Testosterone | 2006 |
[Beneficial effects of combination therapy with losartan and low-dose hydrochlorothiazide in the treatment of essential hypertension].
Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Diuretics; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Tetrazoles | 2005 |
[Plus point -- risk reduction].
Topics: Adrenergic beta-Antagonists; Adult; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Atenolol; Atrial Fibrillation; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diuretics; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Losartan; Placebos; Risk; Risk Factors; Stroke; Time Factors | 2006 |
Antihypertensive agents have different ability to modulate arterial pressure and heart rate variability in 2K1C rats.
Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Atenolol; Autonomic Nervous System; Blood Pressure; Cardiovascular System; Heart Rate; Hydrochlorothiazide; Hypertension; Losartan; Male; Ramipril; Rats; Rats, Wistar; Sympathetic Nervous System | 2006 |
Simultaneous determination of losartan, EXP-3174 and hydrochlorothiazide in plasma via fully automated 96-well-format-based solid-phase extraction and liquid chromatography-negative electrospray tandem mass spectrometry.
Topics: Antihypertensive Agents; Chemical Fractionation; Drug Combinations; Drug Monitoring; Humans; Hydrochlorothiazide; Imidazoles; Losartan; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tetrazoles | 2007 |
Antihypertensive and renal protective effects of renin-angiotensin system blockade in uremic rats treated with erythropoietin.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Captopril; Disease Models, Animal; Drug Therapy, Combination; Erythropoietin; Hydralazine; Hydrochlorothiazide; Hypertension; Kidney; Kidney Failure, Chronic; Losartan; Nephrectomy; Rats; Rats, Wistar; Recombinant Proteins; Renin-Angiotensin System; Reserpine; Time Factors; Uremia | 2006 |
Losartan-hydrochlorothiazide association promotes lasting blood pressure normalization and completely arrests long-term renal injury in the 5/6 ablation model.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Diuretics; Drug Synergism; Glomerulosclerosis, Focal Segmental; Hydrochlorothiazide; Immunohistochemistry; Kidney Diseases; Kidney Function Tests; Losartan; Male; Nephrectomy; Rats; Rats, Wistar; Regional Blood Flow; Renal Circulation; Tail | 2007 |
Cerebral hemodynamics after short- and long-term reduction in blood pressure in mild and moderate hypertension.
Topics: Adaptation, Physiological; Adult; Aged; Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Cerebrovascular Circulation; Drug Administration Schedule; Drug Combinations; Female; Homeostasis; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Posture; Severity of Illness Index; Vascular Resistance; Vasoconstriction | 2007 |
Pulsology reloaded: commentary on similar effects of treatment on central and brachial blood pressure in older hypertensive subjects.
Topics: Aged; Aged, 80 and over; Aging; Amlodipine; Antihypertensive Agents; Atenolol; Blood Pressure; Brachial Artery; Enalapril; Humans; Hydrochlorothiazide; Hypertension; Losartan; Manometry; Perindopril; Ultrasonography, Doppler | 2007 |
Prevention of hypertension abrogates early inflammatory events in the retina of diabetic hypertensive rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Diabetic Retinopathy; Drug Combinations; Eye Proteins; Hydralazine; Hydrochlorothiazide; Hypertension; Immunohistochemistry; Intercellular Adhesion Molecule-1; Losartan; Male; Microglia; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reserpine; Retina; Transcription Factor RelA | 2007 |
[Fixed-combination of losartan/hydrochlorothiazide 100 mg/25 mg. Tolerability and efficacy on blood pressure measured in the practice and for 24 hours].
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Confidence Intervals; Data Interpretation, Statistical; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Prospective Studies; Risk Factors; Sodium Chloride Symporter Inhibitors; Time Factors | 2007 |
Conceptual basis and methodology of the SOPHIA study.
Topics: Adolescent; Adult; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Clinical Trials as Topic; Endpoint Determination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Multicenter Studies as Topic; Pharmacogenetics; Polymorphism, Genetic; Research Design | 2007 |
Simultaneous determination of hydrochlorothiazide and losartan potassium in tablets by high-performance low-pressure chromatography using a multi-syringe burette coupled to a monolithic column.
Topics: Chromatography, High Pressure Liquid; Equipment Design; Hydrochlorothiazide; Losartan; Tablets | 2008 |
Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Genetically Modified; Antihypertensive Agents; Blood Pressure; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Desoxycorticosterone; Heart Ventricles; Humans; Hydralazine; Hydrochlorothiazide; Hypertension, Renal; Kidney; Losartan; Mice; Mineralocorticoid Receptor Antagonists; Nephrosclerosis; p38 Mitogen-Activated Protein Kinases; Rats; Renin; Reserpine; RNA, Messenger; Spironolactone | 2008 |
A multivariate approach for the simultaneous determination of losartan potassium and hydrochlorothiazide in a combined pharmaceutical tablet formulation.
Topics: Chromatography, High Pressure Liquid; Hydrochlorothiazide; Losartan; Multivariate Analysis; Pharmaceutical Preparations; Potassium; Tablets | 2008 |
Multi-syringe chromatography (MSC) system for the on-line solid-phase extraction and determination of hydrochlorothiazide and losartan potassium in superficial water, groundwater and wastewater outlet samples.
Topics: Antihypertensive Agents; Chromatography; Fresh Water; Hydrochlorothiazide; Losartan; Molecular Structure; Online Systems; Solid Phase Extraction; Water; Water Pollutants, Chemical | 2008 |
Application in the STRATHE trial of a score system to compare the efficacy and the tolerability of different therapeutic strategies in the management of hypertension.
Topics: Amlodipine; Antihypertensive Agents; Atenolol; Double-Blind Method; Drug Therapy, Combination; France; Humans; Hydrochlorothiazide; Hypertension; Indapamide; Losartan; Perindopril; Randomized Controlled Trials as Topic; Tetrazoles; Treatment Outcome; Valine; Valsartan | 2008 |
Kidney injury molecule 1: in search of biomarkers of chronic tubulointerstitial damage and disease progression.
Topics: Animals; Antihypertensive Agents; Biomarkers; Chronic Disease; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; Hepatitis A Virus Cellular Receptor 1; Humans; Hydrochlorothiazide; Kidney Diseases; Losartan; Membrane Glycoproteins; Nephritis, Interstitial; Proteinuria; Rats; Receptors, Virus | 2009 |
Cerebral vasomotor reactivity before and after blood pressure reduction in hypertensive patients.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Carbon Dioxide; Cerebrovascular Circulation; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Vasodilation | 2009 |
Efficacy and safety of losartan 100 mg or losartan 100 mg plus hydrochlorothiazide 25 mg in the treatment of patients with essential arterial hypertension and CV risk factors: observational, prospective study in primary care.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Creatinine; Diabetes Complications; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Prospective Studies; Safety | 2009 |
Production and secretion of adiponectin from 3T3-L1 adipocytes: comparison of antihypertensive drugs.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Animals; Antihypertensive Agents; Atenolol; Benzimidazoles; Benzoates; Captopril; Hydrochlorothiazide; Losartan; Mice; Nifedipine; RNA, Messenger; Telmisartan | 2009 |
[Treatment of patients with arterial hypertension and other stroke risk factors in clinical practice. The PROGNOS program].
Topics: Aged; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Risk Factors; Stroke | 2009 |
Greater regression of electrocardiographic left ventricular hypertrophy during hydrochlorothiazide therapy in hypertensive patients.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Drug Therapy, Combination; Electrocardiography; Female; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Losartan; Male; Middle Aged; Randomized Controlled Trials as Topic | 2010 |
Economic evaluation of irbesartan in combination with hydrochlorothiazide in the treatment of hypertension in Greece.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Cardiovascular Diseases; Clinical Trials as Topic; Cost-Benefit Analysis; Drug Combinations; Female; Greece; Humans; Hydrochlorothiazide; Hypertension; Irbesartan; Losartan; Male; Markov Chains; Middle Aged; Models, Economic; Quality of Life; Sex Factors; Tetrazoles; Valine; Valsartan | 2011 |
RAAS blockade in combination with diuretic therapy increases urine excretion, which in turn increases drinking and thus reduces erythropoietin and proteinuria.
Topics: Chronic Disease; Diuretics; Drinking Behavior; Drug Therapy, Combination; Erythropoietin; Hemodilution; Hemoglobins; Humans; Hydrochlorothiazide; Kidney Diseases; Losartan; Proteinuria; Renin-Angiotensin System; Urination | 2010 |
Effects of commonly administered agents and genetics on nebivolol pharmacokinetics: drug-drug interaction studies.
Topics: Adult; Antihypertensive Agents; Benzopyrans; Cytochrome P-450 CYP2D6; Digoxin; Drug Interactions; Ethanolamines; Female; Fluoxetine; Furosemide; Genotype; Humans; Hydrochlorothiazide; Losartan; Male; Middle Aged; Nebivolol; Ramipril; Warfarin; Young Adult | 2011 |
Availability, price and affordability of cardiovascular medicines: a comparison across 36 countries using WHO/HAI data.
Topics: Antihypertensive Agents; Atenolol; Captopril; Cardiovascular Diseases; Cost of Illness; Developing Countries; Health Services Accessibility; Humans; Hydrochlorothiazide; Losartan; Nifedipine; World Health Organization | 2010 |
Is hydrochlorothiazide more effective on LVH in nonresponders to losartan than in those to atenolol?
Topics: Antihypertensive Agents; Atenolol; Electrocardiography; Humans; Hydrochlorothiazide; Hypertrophy, Left Ventricular; Losartan; Randomized Controlled Trials as Topic; Treatment Outcome | 2010 |
Similar renoprotection after renin-angiotensin-dependent and -independent antihypertensive therapy in 5/6-nephrectomized Ren-2 transgenic rats: are there blood pressure-independent effects?
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Creatinine; Diabetic Nephropathies; Diuretics; Drug Therapy, Combination; Furosemide; Hydrochlorothiazide; Hypertension; Indoles; Kidney Failure, Chronic; Labetalol; Losartan; Proteinuria; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Renin; Renin-Angiotensin System | 2010 |
Losartan potassium/hydrochlorothiazide (Preminent®) and hyponatremia: case series of 40 patients.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Hyponatremia; Losartan; Male; Middle Aged; Rhabdomyolysis; Treatment Outcome | 2011 |
[Effects of combination therapy with losartan/hydrochlorothiazide on the relationships between base blood pressure, autonomic function, and health-related QOL].
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Autonomic Nervous System; Blood Pressure; Diuretics; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Kidney Diseases; Losartan; Male; Natriuresis; Quality of Life; Treatment Outcome | 2010 |
Simultaneous spectrophotometric determination of losartan potassium, amlodipine besilate and hydrochlorothiazide in pharmaceuticals by chemometric methods.
Topics: Amlodipine; Chemistry, Pharmaceutical; Hydrochlorothiazide; Least-Squares Analysis; Linear Models; Losartan; Multivariate Analysis; Principal Component Analysis; Spectrophotometry, Ultraviolet; Tablets | 2010 |
Simultaneous spectrophotometric estimation of Hydrochlorothiazide, Atenolol and Losartan potassium in tablet dosage form.
Topics: Antihypertensive Agents; Atenolol; Calibration; Hydrochlorothiazide; Losartan; Spectrophotometry, Ultraviolet; Tablets | 2009 |
Comparative study of hydrochlorothiazide and indapamide on the anti-atherogenic potential of losartan in cholesterol fed rat.
Topics: Animals; Antihypertensive Agents; Atherosclerosis; Body Weight; Cholesterol, Dietary; Diuretics; Hydrochlorothiazide; Indapamide; Lipids; Losartan; Rats; Rats, Long-Evans | 2010 |
Anti-inflammatory effects of anti-hypertensive agents: influence on interleukin-1β secretion by peripheral blood polymorphonuclear leukocytes from patients with essential hypertension.
Topics: Adult; Amlodipine; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Atenolol; Captopril; Case-Control Studies; Female; Humans; Hydrochlorothiazide; Hypertension; In Vitro Techniques; Inflammation Mediators; Interleukin-1beta; Lipopolysaccharides; Losartan; Male; Middle Aged; Neutrophils | 2011 |
Scintigraphic diagnosis of Erdheim-Chester disease.
Topics: Aged; Amlodipine; Antihypertensive Agents; Diabetes Mellitus, Type 2; Drug Combinations; Erdheim-Chester Disease; Gated Blood-Pool Imaging; Humans; Hydrochlorothiazide; Hypoglycemic Agents; Hypolipidemic Agents; Imidazoles; Knee Joint; Losartan; Male; Metformin; Positron-Emission Tomography; Prostatic Neoplasms; Simvastatin | 2011 |
Mechanism underlying the efficacy of combination therapy with losartan and hydrochlorothiazide in rats with salt-sensitive hypertension.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Drug Therapy, Combination; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Losartan; Male; Peptidyl-Dipeptidase A; Rats; Rats, Inbred Dahl; Receptor, Angiotensin, Type 1; Treatment Outcome | 2011 |
Managing erectile dysfunction in hypertensive patients.
Topics: Amides; Antihypertensive Agents; Benzopyrans; Chlorthalidone; Ethanolamines; Fumarates; Humans; Hydrochlorothiazide; Hypertension; Impotence, Vasculogenic; Losartan; Male; Middle Aged; Nebivolol; Risk Factors | 2011 |
Effects of losartan, in monotherapy or in association with hydrochlorothiazide, in chronic nephropathy resulting from losartan treatment during lactation.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Blood Pressure; Chronic Disease; Disease Models, Animal; Diuretics; Drug Therapy, Combination; Female; Hydrochlorothiazide; Kidney; Kidney Diseases; Lactation; Losartan; Male; Nephrons; Rats; Rats, Inbred Strains | 2011 |
Effect of fixed-dose losartan/hydrochlorothiazide on brain natriuretic peptide in patients with hypertension.
Topics: Aged; Blood Pressure; Body Weight; Diastole; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Natriuretic Peptide, Brain; Systole | 2012 |
Antihypertensive treatment using an angiotensin receptor blocker and a thiazide diuretic improves patients' quality of life: the Saga Challenge Antihypertensive Study (S-CATS).
Topics: Age Factors; Aged; Angiotensin II Type 2 Receptor Blockers; Antihypertensive Agents; Blood Chemical Analysis; Blood Pressure; Data Interpretation, Statistical; Diuretics; Drug Combinations; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Japan; Losartan; Male; Middle Aged; Prospective Studies; Quality of Life; Sleep; Surveys and Questionnaires | 2011 |
Losartan modulates muscular capillary density and reverses thiazide diuretic-exacerbated insulin resistance in fructose-fed rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Capillaries; Fructose; Glucose Clamp Technique; Hydrochlorothiazide; Insulin Resistance; Losartan; Male; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System | 2012 |
Beneficial effect of switching from a combination of angiotensin II receptor blockers other than losartan and thiazides to a fixed dose of losartan/hydrochlorothiazide on uric acid metabolism in hypertensive patients.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Hydrogen-Ion Concentration; Hypertension; Hyperuricemia; Losartan; Male; Middle Aged; Organic Anion Transporters; Organic Cation Transport Proteins; Treatment Outcome; Uric Acid | 2011 |
Anti-hypertensive therapy and insulin sensitivity: regulation through the microcirculation?
Topics: Animals; Capillaries; Fructose; Hydrochlorothiazide; Insulin Resistance; Losartan; Male; Muscle, Skeletal | 2012 |
STK39 variation predicts the ambulatory blood pressure response to losartan in hypertensive men.
Topics: Adult; Alleles; Amlodipine; Antihypertensive Agents; Bisoprolol; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Genotype; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Polymorphism, Single Nucleotide; Protein Serine-Threonine Kinases | 2012 |
Comparison of the efficacy and safety of single-pill fixed-dose combinations of losartan/hydrochlorothiazide and valsartan/hydrochlorothiazide in patients with hypertension (SALT-VAT study).
Topics: Aged; Blood Pressure; Drug Combinations; Drug Substitution; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Tetrazoles; Treatment Outcome; Valine; Valsartan | 2011 |
The pharmacokinetic-pharmacodynamic assessment of the hypotensive effect after coadministration of losartan and hydrochlorothiazide in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Drug Therapy, Combination; Hydrochlorothiazide; Hypertension; Losartan; Male; Rats; Rats, Inbred SHR; Treatment Outcome | 2012 |
Antihypertensive effect of a fixed-dose combination of losartan/hydrochlorothiazide in patients with uncontrolled hypertension: a multicenter study.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Creatinine; Drug Combinations; Female; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Hypertension; Hyperuricemia; Japan; Losartan; Male; Middle Aged; Natriuretic Peptide, Brain; Prospective Studies; Treatment Outcome; Uric Acid; Young Adult | 2012 |
An economic evaluation of antihypertensive therapies based on clinical trials.
Topics: Amlodipine; Antihypertensive Agents; Atenolol; Blood Pressure; Drug Costs; Drug Therapy, Combination; Enalapril; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Randomized Controlled Trials as Topic | 2012 |
Effect of combination therapy with the angiotensin receptor blocker losartan plus hydrochlorothiazide on brain perfusion in patients with both hypertension and cerebral hemodynamic impairment due to symptomatic chronic major cerebral artery steno-occlusiv
Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Arterial Occlusive Diseases; Carotid Stenosis; Cerebral Arterial Diseases; Cerebrovascular Circulation; Cerebrovascular Disorders; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Iofetamine; Losartan; Male; Middle Aged; Middle Cerebral Artery; Platelet Aggregation Inhibitors; Prospective Studies; Radiopharmaceuticals; Risk Factors; Tomography, Emission-Computed, Single-Photon | 2012 |
Impact of the combination of an angiotensin II receptor blocker and low-dose hydrochlorothiazide on patients with morning hypertension.
Topics: Antihypertensive Agents; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male | 2012 |
Aldosterone does not require angiotensin II to activate NCC through a WNK4-SPAK-dependent pathway.
Topics: Adrenalectomy; Aldosterone; Amiloride; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Diuretics; Dose-Response Relationship, Drug; Hydrochlorothiazide; Kidney; Losartan; Models, Animal; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium Chloride Symporters | 2012 |
Activation of thiazide-sensitive co-transport by angiotensin II in the cyp1a1-Ren2 hypertensive rat.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cytochrome P-450 CYP1A1; Hydrochlorothiazide; Hypertension; Kidney Tubules, Distal; Losartan; Male; Microvessels; Natriuresis; Rats; Rats, Transgenic; Renin; Sodium Chloride Symporters; Spironolactone | 2012 |
Clinical efficacy and safety of losartan/hydrochlorothiazide combination therapy.
Topics: Antihypertensive Agents; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male | 2012 |
Saliva versus plasma pharmacokinetics: theory and application of a salivary excretion classification system.
Topics: Acetates; Anthraquinones; Azithromycin; Benzhydryl Compounds; Cinacalcet; Cloxacillin; Cresols; Cyclopropanes; Female; Fluorobenzenes; Humans; Hydrochlorothiazide; Losartan; Male; Metformin; Naphthalenes; Phenylpropanolamine; Piroxicam; Pyrazines; Pyrimidines; Quinolines; Rosuvastatin Calcium; Saliva; Sitagliptin Phosphate; Sulfides; Sulfonamides; Tamsulosin; Tolterodine Tartrate; Triazoles | 2012 |
Adding thiazide to a rennin-angiotensin blocker regimen to improve left ventricular relaxation in diabetes and nondiabetes patients with hypertension.
Topics: Adult; Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; C-Reactive Protein; Creatinine; Diabetes Mellitus; Drug Therapy, Combination; Echocardiography; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Ventricular Function, Left | 2012 |
Combination therapy with losartan/hydrochlorothiazide for blood pressure reduction and goal attainment in a real-world clinical setting in Japan.
Topics: Age Factors; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Comorbidity; Databases, Factual; Diabetes Mellitus; Diuretics; Drug Combinations; Drug Prescriptions; Female; Guideline Adherence; Humans; Hydrochlorothiazide; Hypertension; Japan; Losartan; Male; Middle Aged; Practice Guidelines as Topic; Practice Patterns, Physicians'; Prevalence; Renal Insufficiency, Chronic; Retrospective Studies; Sex Factors; Time Factors; Treatment Outcome | 2012 |
Effects of a fixed combination of losartan with hydrochlorothiazide on glucose tolerance in hypertensive patients uncontrolled with angiotensin ii receptor blockers alone.
Topics: Aged; Angiotensin Receptor Antagonists; Drug Combinations; Female; Glucose Tolerance Test; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged | 2013 |
Regression of albuminuria and hypertension and arrest of severe renal injury by a losartan-hydrochlorothiazide association in a model of very advanced nephropathy.
Topics: Acute Kidney Injury; Albuminuria; Aldosterone; Animals; Antihypertensive Agents; Drug Therapy, Combination; Glomerulonephritis; Hydrochlorothiazide; Hypertension; Kidney; Losartan; Male; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Renal Insufficiency, Chronic | 2013 |
Toward a personalized chronotherapy of high blood pressure and a circadian overswing.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Drug Chronotherapy; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Models, Cardiovascular; Precision Medicine | 2013 |
Significance of estimated salt excretion as a possible predictor of the efficacy of concomitant angiotensin receptor blocker (ARB) and low-dose thiazide in patients with ARB resistance.
Topics: Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Sodium Chloride; Sodium Chloride Symporter Inhibitors; Treatment Outcome | 2013 |
Impact of antihypertensive medication adherence on blood pressure control in hypertension: the COMFORT study.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Japan; Losartan; Male; Medication Adherence; Middle Aged; Patient Education as Topic; Prospective Studies; Treatment Outcome | 2013 |
Phase quantification of antihypertensive drugs - Chlorthalidone, Hydrochlorothiazide, Losartan and combinations, Losartan/Chlorthalidone and Losartan/Hydrochlorothiazide - by the Rietveld method.
Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Chemistry, Pharmaceutical; Chlorthalidone; Crystallization; Diuretics; Drug Stability; Hydrochlorothiazide; Losartan; Powders; Temperature; Time Factors; X-Ray Diffraction | 2014 |
Release from glomerular overload by the addition of low-dose thiazide in patients with angiotensin receptor blocker-resistant hypertension.
Topics: Aged; Aged, 80 and over; Albuminuria; Angiotensin II Type 1 Receptor Blockers; Dose-Response Relationship, Drug; Drug Combinations; Essential Hypertension; Female; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Hypertension; Kidney Glomerulus; Losartan; Male; Middle Aged; Prospective Studies | 2013 |
Medication nonadherence due to misunderstanding of the salt form.
Topics: Antihypertensive Agents; Benzazepines; Drug Labeling; Humans; Hydrochlorothiazide; Losartan; Medication Adherence; Medication Errors; Patient Education as Topic; Salts; Terminology as Topic | 2014 |
Economic evaluation of primary prevention of cardiovascular diseases in mild hypertension: a scenario analysis for the Netherlands.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Cardiovascular Diseases; Cost-Benefit Analysis; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Markov Chains; Middle Aged; Netherlands; Primary Prevention; Risk Factors; Smoking | 2014 |
Effects of a combination of losartan and hydrochlorothiazide in patients with hypertension and a history of heart failure.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biomarkers; Blood Pressure; Diuretics; Drug Substitution; Drug Therapy, Combination; Female; Heart Failure; Heart Function Tests; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Natriuretic Peptide, Brain; Patient Compliance; Treatment Outcome | 2014 |
Therapeutic impact of the single fixed-dose combination with a high-dose angiotensin-receptor blocker and a low-dose thiazide diuretic in the management of hypertension: awaiting further accumulation of clinical evidence.
Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Diuretics; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male | 2014 |
Left ventricular hypertrophy as a target of treatment in patients with hypertension.
Topics: Angiotensin Receptor Antagonists; Electrocardiography; Humans; Hydrochlorothiazide; Hypertrophy, Left Ventricular; Losartan; Male | 2014 |
Antihypertensive effectiveness of combination therapy with losartan/hydrochlorothiazide for 'real world' management of isolated systolic hypertension.
Topics: Adult; Aged; Cross-Sectional Studies; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Retrospective Studies; Systole | 2015 |
Genome-wide association study identifies CAMKID variants involved in blood pressure response to losartan: the SOPHIA study.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Calcium-Calmodulin-Dependent Protein Kinase Type 1; Female; Genome-Wide Association Study; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Polymorphism, Single Nucleotide | 2014 |
Metabolic approaches to antihypertensive treatment in diabetic patients.
Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Benzoates; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Diuretics; Female; Humans; Hydrochlorothiazide; Hypertension; Insulin Resistance; Losartan; Male; Nifedipine | 2015 |
An association of losartan-hydrochlorothiazide, but not losartan-furosemide, completely arrests progressive injury in the remnant kidney.
Topics: Albuminuria; Animals; Blood Pressure; Drug Combinations; Furosemide; Hydrochlorothiazide; Hypertension; Kidney; Losartan; Male; Rats; Rats, Wistar; Renal Circulation | 2016 |
Norepinephrine-evoked salt-sensitive hypertension requires impaired renal sodium chloride cotransporter activity in Sprague-Dawley rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Hydrochlorothiazide; Hypertension; Kidney; Losartan; Male; Natriuresis; Norepinephrine; Rats, Sprague-Dawley; Renin-Angiotensin System; Sodium Chloride Symporter Inhibitors; Sodium Chloride, Dietary; Solute Carrier Family 12, Member 3; Sympathetic Nervous System; Time Factors | 2016 |
Cost-benefit analysis of the polypill in the primary prevention of myocardial infarction and stroke.
Topics: Aged; Aged, 80 and over; Amlodipine; Aspirin; Cardiovascular Agents; Case-Control Studies; Cohort Studies; Cost-Benefit Analysis; Humans; Hydrochlorothiazide; Losartan; Markov Chains; Middle Aged; Myocardial Infarction; Polypharmacy; Primary Prevention; Quality-Adjusted Life Years; Simvastatin; Stroke; United Kingdom | 2016 |
Starting the polypill: the use of a single age cut-off in males and females.
Topics: Adult; Age Factors; Aged; Cardiovascular Agents; Drug Combinations; Female; Humans; Hydrochlorothiazide; Losartan; Male; Middle Aged; Myocardial Infarction; Preventive Health Services; Simvastatin; State Medicine; Stroke; United Kingdom | 2017 |
Simultaneous Determination of Hydrochlorothiazide and Losartan Potassium in Osmotic Pump Tablets by Microemulsion Liquid Chromatography.
Topics: Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Chromatography, Liquid; Emulsions; Hydrochlorothiazide; Losartan; Reproducibility of Results | 2016 |
Cost-effectiveness of the polypill versus risk assessment for prevention of cardiovascular disease.
Topics: Administration, Oral; Adult; Aged; Amlodipine; Antihypertensive Agents; Cardiovascular Diseases; Computer Simulation; Cost-Benefit Analysis; Drug Combinations; Drug Costs; Dyslipidemias; Female; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Losartan; Male; Middle Aged; Models, Economic; Primary Prevention; Quality-Adjusted Life Years; Risk Assessment; Risk Factors; Simvastatin; Tablets; Time Factors; Treatment Outcome | 2017 |
Chlorothiazide-induced photoaggravation of psoriatic lesion during narrowband ultraviolet B treatment in a case of psoriasis vulgaris.
Topics: Aged; Disease Progression; Drug Combinations; Female; Ficusin; Humans; Hydrochlorothiazide; Hypertension; Losartan; Photochemotherapy; Psoriasis; Severity of Illness Index; Treatment Outcome; Ultraviolet Therapy | 2017 |
Association of obstructive sleep apnea with arterial stiffness and nondipping blood pressure in patients with hypertension.
Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Brazil; Cardiovascular Diseases; Diuretics; Echocardiography; Enalapril; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Polysomnography; Pulse Wave Analysis; Risk Factors; Sleep Apnea, Obstructive; Vascular Stiffness | 2017 |
Losartan/hydrochlorothiazide combination is safe and effective for morning hypertension in Very-Elderly patients.
Topics: Age Factors; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Diuretics; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Kidney; Losartan; Male; Middle Aged; Potassium; Time Factors; Treatment Outcome | 2018 |
Evaluation of Drug-Induced Photosensitivity Using the Japanese Adverse Drug Event Report (JADER) Database.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Female; Humans; Hydrochlorothiazide; Incidence; Japan; Ketoprofen; Losartan; Male; Middle Aged; Odds Ratio; Photosensitivity Disorders; Seasons; Sodium Chloride Symporter Inhibitors; Valsartan; Young Adult | 2017 |
Green-modified micellar liquid chromatography for isocratic isolation of some cardiovascular drugs with different polarities through experimental design approach.
Topics: Cardiovascular Agents; Chromatography, High Pressure Liquid; Humans; Hydrochlorothiazide; Hydrophobic and Hydrophilic Interactions; Losartan; Micelles; Research Design; Software; Triamterene; United States; United States Food and Drug Administration | 2018 |
Cytotoxic and genotoxic effects of antihypertensives distributed in Brazil by social programs: Are they safe?
Topics: Antihypertensive Agents; Atenolol; Brazil; Captopril; Cell Survival; Cells, Cultured; DNA Damage; Dose-Response Relationship, Drug; Enalapril; Government Programs; Humans; Hydrochlorothiazide; Hypertension; Losartan; Lymphocytes; Macrophages; Male; Mutagenicity Tests; Program Evaluation; Propranolol | 2018 |
Effects of Different Antihypertensive Drug Combinations on Blood Pressure and Arterial Stiffness.
Topics: Aged; Amlodipine; Antihypertensive Agents; Arteries; Blood Pressure; Diastole; Drug Combinations; Essential Hypertension; Female; Humans; Hydrochlorothiazide; Lisinopril; Losartan; Male; Middle Aged; Prospective Studies; Pulse Wave Analysis; Systole; Valsartan; Vascular Resistance; Vascular Stiffness | 2019 |
The smoothness index: an 'all purposes' approach to the assessment of the homogeneity of 24-h blood pressure control?
Topics: Amlodipine; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Hydrochlorothiazide; Losartan; Pulse Wave Analysis | 2019 |
HPLC method transfer study for simultaneous determination of seven angiotensin II receptor blockers.
Topics: Acrylates; Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Chlorthalidone; Chromatography, High Pressure Liquid; Hydrochlorothiazide; Imidazoles; Irbesartan; Losartan; Molecular Structure; Software; Tablets; Tetrazoles; Thiophenes; Valsartan | 2020 |
Applications of shun shell column and nanocomposite sorbent for analysis of eleven anti-hypertensive in human plasma.
Topics: Adsorption; Antihypertensive Agents; Chromatography, High Pressure Liquid; Diltiazem; Furosemide; Humans; Hydrochlorothiazide; Irbesartan; Iron; Labetalol; Limit of Detection; Losartan; Metal Nanoparticles; Methyldopa; Nanocomposites; Polyvinyl Alcohol; Prazosin; Propranolol; Reproducibility of Results; Solid Phase Microextraction; Spironolactone; Valsartan | 2020 |
Clinical efficacy of various anti-hypertensive regimens in hypertensive women of Punjab; a longitudinal cohort study.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cohort Studies; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Longitudinal Studies; Losartan; Male; Middle Aged; Nifedipine; Pakistan; Treatment Outcome | 2020 |
UV-Vis LED-assisted photo-Fenton process for mineralization of losartan and hydrochlorothiazide: optimization using desirability function.
Topics: Hydrochlorothiazide; Hydrogen Peroxide; Iron; Kinetics; Losartan; Oxidation-Reduction; Ultraviolet Rays; Water Pollutants, Chemical | 2021 |
Cyclooxygenase-2 is a critical determinant of angiotensin II-induced vascular remodeling and stiffness in resistance arteries of ouabain-treated rats.
Topics: Angiotensin II; Animals; bcl-2-Associated X Protein; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Hydrochlorothiazide; Losartan; Matrix Metalloproteinase 2; Mesenteric Arteries; Ouabain; Rats; Rats, Wistar; Reactive Oxygen Species; Vascular Remodeling; Vascular Resistance | 2022 |
Development and optimization of a LC-MS/MS compatible method for quantification of losartan, hydrochlorothiazide and their impurities using AQbD approach and measurement uncertainty evaluation.
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Hydrochlorothiazide; Losartan; Reproducibility of Results; Tandem Mass Spectrometry; Uncertainty | 2023 |