losartan and furosemide

losartan has been researched along with furosemide in 74 studies

Research

Studies (74)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	27 (36.49)	18.2507
2000's	20 (27.03)	29.6817
2010's	23 (31.08)	24.3611
2020's	4 (5.41)	2.80

Authors

Authors	Studies
Strassburg, CP; Tukey, RH	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Avdeef, A; Tam, KY	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Barton, P; Luker, T; Wenlock, MC	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA	1
Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF	1
Clozel, JP; Fischli, W; Hess, P; Véniant, M	1
Gavras, H; Gavras, I; Wang, YX; Wierzba, T	1
Duncia, JV; Hart, SD; Timmermans, PB; Wong, PC	1
Carini, DJ; Chiu, AT; Duncia, JV; Johnson, AL; Price, WA; Timmermans, PB; Wexler, RR; Wong, PC	1
Andoh, TF; Bennett, WM; Burdmann, EA; Coffman, TM; Connors, BA; Evan, A; Lindsley, J; Nast, CC	1
Doig, JK; MacFadyen, RJ; Reid, JL; Sweet, CS	1
Doig, JK; Lees, KR; MacFadyen, RJ; Reid, JL; Sweet, CS	1
Berdeaux, A; Giudicelli, JF; Richard, V	1
Ebihara, A; Fujimura, A; Sudoh, T	1
Eerdmans, PH; Janssen, BJ; Smits, JF	1
Johnson, AK; Thunhorst, RL	1
Berdeaux, A; Ghaleh, B; Giudicelli, JF; Richard, V	1
DiBona, GF; Petersen, JS	1
Almansa, C; Carceller, E; Cavalcanti, FL; de Arriba, AF; Forn, J; García-Rafanell, J; Gómez, LA; Rodríguez, R	1
Findlay, AL	1
Ajikobi, DO; Cupples, WA; Novak, P; Salevsky, FC	1
Chong, CK; Honrath, U; Sonnenberg, H; Veress, AT	2
Blair-West, JR; Burns, P; Denton, DA; Tarjan, E; Weisinger, RS	1
Boon, NA; Johnston, NR; Masumori, S; Newby, DE; Webb, DJ	1
Fujimori, A; Inagaki, O; Kikuchi, K; Kurihara, H; Okazaki, T; Shibasaki, M; Suga, A; Watanabe, T; Yanagisawa, U	1
Fujimori, A; Inagaki, O; Kikuchi, K; Okazaki, T; Shibasaki, M; Suga, A; Watanabe, T; Yanagisawa, I	1
Lane, PH; Schmitz, PG; Tyler, LD	1
Beltz, TG; Colombari, DS; Johnson, AK; Menani, JV; Thunhorst, RL	1
Baumohl, Y; Blatt, A; Cotter, G; Golik, A; Kaluski, E; Litinsky, I; Metzkor-Cotter, E; Moshkovitz, Y; Vered, Z; Zaidenstein, R	1
Kwon, KJ; Lee, BH; Seo, HW; Shin, HS; Yoo, SE	1
Jung, YS; Lee, BH; Lee, SH; Seo, HW; Shin, HS; Yoo, SE	1
Fitch, GK; Weiss, ML	1
Esposito, G; Fox, JE; Hagaman, JR; Knowles, JW; Maeda, N; Mao, L; Rockman, HA; Smithies, O	1
Khazine, F; Simons, O	1
Badzyńska, B; Dobrowolski, L; Grzelec-Mojzesowicz, M; Sadowski, J	1
Antunes Rodrigues, J; Badauê-Passos, D; Olivares, EL; Ramalho, MJ; Reis, LC; Silva, LF; Ventura, RR	1
Kohno, M; Masugata, H; Ohmori, K; Ohnishi, K; Takagi, Y; Wada, Y; Yukiiri, K	1
Hada, T; Moriwaki, Y; Takahashi, S; Tsutsumi, Z; Yamamoto, T	1
Climent, V; López, I; Manso, MI; Murcia, J; Reus, S; Tello, A	1
Burnett, JC; Cataliotti, A; Chen, HH; Nordstrom, LJ; Redfield, MM	1
Chan, EC; Chong, K; Wargo, KA	1
Cerri, PS; de Arruda Camargo, GM; de Arruda Camargo, LA; Saad, WA	1
Greene, AS; Munzenmaier, DH	1
Hirooka, K; Isobe, F; Saito, M; Takada, M; Yasumura, Y	1
Antônio de Arruda Camargo, L; Maria Pavan de Arruda Camargo, G; Saad, WA	1
Araujo, IG; Fonseca, FV; Lepletier, A; Mecawi, AS; Reis, LC	1
Anguita, M; Castillo, JC; León, C; Toledano, F	1
De Luca, LA; Menani, JV; Pereira, DT	1
Gorski, JC; Lindamood, C; Ortiz, S; Rackley, R; Shaw, A	1
Cervenka, L; Chábová, VČ; Husková, Z; Kompanowska-Jezierska, E; Kopkan, L; Kramer, HJ; Kujal, P; Malý, J; Netuka, I; Opočenský, M; Rakušan, D; Sadowski, J; Schejbalová, S; Skaroupková, P; Vaněčková, I; Vaňourková, Z; Vernerová, Z; Walkowska, A	1
Handler, J	1
Callera, JC; Da Silva, CZ; Menani, JV	2
Asnar, DS; Colombari, DS; De Luca, LA; de Paula, PM; Menani, JV; Roncari, CF	1
Chen, K; Hu, B; Qiao, H; Song, L; Sun, B; Sun, HL; Wang, Q; Yan, JB; Yan, JQ; Yan, W; Zhang, Y; Zhao, SR; Zhao, XL	1
Chong, E; Kalia, V; Willsie, S; Winkle, P	1
Fan, Y; Hu, B; Jia, R; Lu, B; Qiao, H; Sun, B; Wang, N; Yan, JQ	1
Arias, SC; Fanelli, C; Fujihara, CK; Malheiros, DM; Souza, RA; Zatz, R	1
Höcherl, K; Thurner, LR	1
Aboul-Enein, HY; Ali, I; ALOthman, ZA; Alsheetan, KM	1
Andrade, CAF; Andrade-Franzé, GMF; De Luca, LA; Faria, AM; Menani, JV; Pereira, ED	1
Correia, AT; Guimarães, LL; Roveri, V; Toma, W	1

Reviews

4 review(s) available for losartan and furosemide

Article	Year
Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annual review of pharmacology and toxicology, 2000, Volume: 40 Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic	2000
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators. European journal of medicinal chemistry, 2022, Jul-05, Volume: 237 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Neoplasm Proteins; Neoplastic Stem Cells	2022
[Hypertension, hypertensive heart disease and heart failure. Role of loop diuretics]. Medicina clinica, 2008, Nov-15, Volume: 131, Issue:17 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Clinical Trials as Topic; Diuretics; Echocardiography, Doppler; Furosemide; Heart Failure; Humans; Hypertension; Hypertrophy, Left Ventricular; Losartan; Meta-Analysis as Topic; Risk Factors; Sodium Potassium Chloride Symporter Inhibitors; Stroke Volume; Sulfonamides; Torsemide	2008

Trials

8 trial(s) available for losartan and furosemide

Article	Year
Haemodynamic and renal responses to oral losartan potassium during salt depletion or salt repletion in normal human volunteers. Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:4 Topics: Adult; Aldosterone; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Creatinine; Double-Blind Method; Electrolytes; Furosemide; Heart Rate; Hemodynamics; Humans; Imidazoles; Kidney; Losartan; Male; Renin; Sodium; Tetrazoles	1995
Dose-ranging study of the angiotensin type I receptor antagonist losartan (DuP753/MK954), in salt-deplete normal man. Journal of cardiovascular pharmacology, 1993, Volume: 21, Issue:5 Topics: Adult; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Pressure; Diet, Sodium-Restricted; Dose-Response Relationship, Drug; Double-Blind Method; Electrolytes; Furosemide; Heart Rate; Humans; Imidazoles; Losartan; Male; Natriuresis; Renin; Sodium; Tetrazoles	1993
Endogenous angiotensin II contributes to basal peripheral vascular tone in sodium deplete but not sodium replete man. Cardiovascular research, 1997, Volume: 36, Issue:2 Topics: Adult; Analysis of Variance; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Vessels; Bradykinin; Diuretics; Dose-Response Relationship, Drug; Forearm; Furosemide; Humans; Losartan; Lower Body Negative Pressure; Male; Norepinephrine; Regional Blood Flow; Sodium; Sodium, Dietary; Vasoconstriction; Vasoconstrictor Agents	1997
Usefulness of losartan, captopril, and furosemide in preventing nitrate tolerance and improving control of unstable angina pectoris. The American journal of cardiology, 1998, Nov-01, Volume: 82, Issue:9 Topics: Adult; Aged; Angina, Unstable; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Captopril; Diuretics; Drug Therapy, Combination; Drug Tolerance; Female; Furosemide; Humans; Isosorbide Dinitrate; Losartan; Male; Middle Aged; Prospective Studies	1998
Influence of the angiotensin II receptor antagonist losartan on diuretic-induced metabolic effects in elderly hypertensive patients: comparison with a calcium channel blocker. International journal of clinical pharmacology and therapeutics, 2001, Volume: 39, Issue:10 Topics: Aged; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diuretics; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Furosemide; Humans; Hypertension; Losartan; Male; Nifedipine; Trichlormethiazide	2001
Angiotensin II AT1 receptor antagonism prevents detrimental renal actions of acute diuretic therapy in human heart failure. American journal of physiology. Renal physiology, 2003, Volume: 284, Issue:5 Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Cross-Over Studies; Diuretics; Double-Blind Method; Drug Therapy, Combination; Furosemide; Glomerular Filtration Rate; Heart Failure; Humans; Kidney; Kidney Diseases; Losartan; Receptor, Angiotensin, Type 1; Renal Circulation; Renin	2003
Serum concentration of potassium in chronic heart failure patients administered spironolactone plus furosemide and either enalapril maleate, losartan potassium or candesartan cilexetil. Journal of clinical pharmacy and therapeutics, 2005, Volume: 30, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Diuretics; Drug Therapy, Combination; Enalapril; Female; Furosemide; Heart Failure; Humans; Hyperkalemia; Losartan; Male; Middle Aged; Potassium; Sodium Potassium Chloride Symporter Inhibitors; Spironolactone	2005
Drug-drug interactions between sucroferric oxyhydroxide and losartan, furosemide, omeprazole, digoxin and warfarin in healthy subjects. Journal of nephrology, 2014, Volume: 27, Issue:6 Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Anticoagulants; Area Under Curve; Cardiotonic Agents; Chelating Agents; Digoxin; Diuretics; Drug Administration Schedule; Drug Combinations; Drug Interactions; Female; Ferric Compounds; Furosemide; Half-Life; Healthy Volunteers; Humans; Losartan; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Models, Statistical; Omeprazole; Proton Pump Inhibitors; Risk Assessment; Sucrose; Warfarin; Young Adult	2014

Other Studies

62 other study(ies) available for losartan and furosemide

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Lipophilicity of acidic compounds: impact of ion pair partitioning on drug design. Bioorganic & medicinal chemistry letters, 2011, Jun-15, Volume: 21, Issue:12 Topics: Acids; Albumins; Drug Design; Humans; Hydrogen-Ion Concentration; Lipids; Molecular Structure; Pharmaceutical Preparations; Protein Binding	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3 Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs	2013
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump. Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:3 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index	2014
Effects of renin-angiotensin system blockade in guinea pigs. Hypertension (Dallas, Tex. : 1979), 1992, Volume: 19, Issue:3 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Bradykinin; Cilazapril; Cyclooxygenase Inhibitors; Disease Models, Animal; Furosemide; Guinea Pigs; Hypertension; Imidazoles; Indomethacin; Losartan; Nephrectomy; Oligopeptides; Pyridazines; Renin; Renin-Angiotensin System; Tetrazoles	1992
Comparison of systemic and regional hemodynamic effects of a diuretic, an angiotensin II receptor antagonist, and an angiotensin-converting enzyme inhibitor in conscious renovascular hypertensive rats. The Journal of laboratory and clinical medicine, 1992, Volume: 119, Issue:3 Topics: Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Consciousness; Enalapril; Furosemide; Hemodynamics; Hypertension, Renovascular; Imidazoles; Kidney; Losartan; Male; Rats; Skin; Skin Physiological Phenomena; Spleen; Stomach; Tetrazoles; Vascular Resistance	1992
Nonpeptide angiotensin II receptor antagonists. Studies with DuP 753 and EXP3174 in dogs. European journal of pharmacology, 1991, Sep-24, Volume: 202, Issue:3 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Captopril; Dogs; Female; Furosemide; Imidazoles; Kidney; Kidney Function Tests; Losartan; Male; Pyridines; Radioimmunoassay; Renin-Angiotensin System; Tetrazoles	1991
Hypotensive action of DuP 753, an angiotensin II antagonist, in spontaneously hypertensive rats. Nonpeptide angiotensin II receptor antagonists: X. Hypertension (Dallas, Tex. : 1979), 1990, Volume: 15, Issue:5 Topics: Administration, Oral; Angiotensin II; Animals; Antihypertensive Agents; Azoles; Captopril; Furosemide; Imidazoles; Injections, Intravenous; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazoles	1990
Prevention of experimental cyclosporin-induced interstitial fibrosis by losartan and enalapril. The American journal of physiology, 1995, Volume: 269, Issue:4 Pt 2 Topics: Animals; Biphenyl Compounds; Blood Pressure; Cyclosporine; Enalapril; Furosemide; Hydralazine; Imidazoles; Kidney; Kidney Diseases; Losartan; Male; Microscopy, Electron, Scanning; Rats; Rats, Sprague-Dawley; Renin; RNA, Messenger; Tetrazoles	1995
Systemic and coronary effects of the angiotensin II receptor antagonist EXP3174 in dogs. Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:1 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Coronary Circulation; Dogs; Enalaprilat; Female; Furosemide; Hemodynamics; Imidazoles; Losartan; Male; Renin-Angiotensin System; Tetrazoles	1993
Effect of angiotensin II type 1 receptor antagonist on urinary prostaglandin E2 excretion following furosemide in rats. Life sciences, 1994, Volume: 55, Issue:9 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Dinoprostone; Furosemide; Imidazoles; Indans; Losartan; Male; Prodrugs; Rats; Rats, Wistar; Tetrazoles	1994
Mechanisms of renal vasoconstriction following furosemide in conscious rats. Naunyn-Schmiedeberg's archives of pharmacology, 1994, Volume: 349, Issue:5 Topics: Animals; Antihypertensive Agents; Biphenyl Compounds; Captopril; Chlorthalidone; Dose-Response Relationship, Drug; Drug Interactions; Furosemide; Hemodynamics; Imidazoles; Kidney; Losartan; Male; Rats; Rats, Wistar; Regional Blood Flow; Renal Artery; Tetrazoles; Vascular Resistance; Vasoconstriction	1994
Renin-angiotensin, arterial blood pressure, and salt appetite in rats. The American journal of physiology, 1994, Volume: 266, Issue:2 Pt 2 Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Appetite; Biphenyl Compounds; Blood Pressure; Body Weight; Captopril; Creatinine; Furosemide; Imidazoles; Losartan; Male; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Sodium; Sodium, Dietary; Tetrazoles; Time Factors; Urine	1994
Comparison of the effects of EXP3174, an angiotensin II antagonist and enalaprilat on myocardial infarct size in anaesthetized dogs. British journal of pharmacology, 1993, Volume: 110, Issue:3 Topics: Anesthesia; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Coronary Circulation; Disease Models, Animal; Dogs; Enalaprilat; Female; Furosemide; Heart Rate; Imidazoles; Injections, Intravenous; Losartan; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Renin-Angiotensin System; Tetrazoles	1993
Furosemide elicits immediate sympathoexcitation via a renal mechanism independent of angiotensin II. Pharmacology & toxicology, 1995, Volume: 77, Issue:2 Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Diuretics; Ethanolamine; Ethanolamines; Furosemide; Heart Rate; Imidazoles; Injections, Intravenous; Injections, Intraventricular; Losartan; Male; Neurons, Efferent; Rats; Rats, Sprague-Dawley; Renin; Sympathetic Nervous System; Tetrazoles	1995
Diphenylpropionic acids as new AT1 selective angiotensin II antagonists. Journal of medicinal chemistry, 1996, May-24, Volume: 39, Issue:11 Topics: Administration, Oral; Adrenal Glands; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Biphenyl Compounds; Blood Pressure; Diet, Sodium-Restricted; Furosemide; Imidazoles; In Vitro Techniques; Indicators and Reagents; Kinetics; Liver; Losartan; Male; Models, Molecular; Molecular Structure; Muscle, Smooth, Vascular; Phenylpropionates; Rabbits; Rats; Stereoisomerism; Structure-Activity Relationship; Tetrazoles	1996
The effect of losartan on drinking and NaCl intake in the rat in response to hyperosmotic and hypovolaemic stimuli: effect of route of administration and strain of rat. Regulatory peptides, 1996, Oct-08, Volume: 66, Issue:1-2 Topics: Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Diuretics; Drinking; Drinking Behavior; Furosemide; Imidazoles; Injections, Intraventricular; Injections, Subcutaneous; Losartan; Male; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Saline Solution, Hypertonic; Shock; Sodium; Tetrazoles	1996
Pharmacological modulation of spontaneous renal blood flow dynamics. Canadian journal of physiology and pharmacology, 1996, Volume: 74, Issue:8 Topics: Anesthetics, Inhalation; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Bumetanide; Diuretics; Drug Interactions; Feedback; Furosemide; Halothane; Imidazoles; Isoflurane; Kidney Glomerulus; Kidney Tubules; Losartan; Male; Natriuresis; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Renal Circulation; Tetrazoles; Vasoconstrictor Agents	1996
Effect of sympathetic and angiotensin-aldosterone systems on renal salt conservation in the rat. The American journal of physiology, 1997, Volume: 272, Issue:4 Pt 2 Topics: Adrenalectomy; Aldosterone; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Body Water; Body Weight; Dexamethasone; Diet, Sodium-Restricted; Diuresis; Electrolytes; Epinephrine; Furosemide; Hematocrit; Homeostasis; Imidazoles; Kidney; Losartan; Male; Norepinephrine; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Sodium, Dietary; Sympathectomy, Chemical; Sympathetic Nervous System; Tetrazoles; Water-Electrolyte Balance	1997
Renal resistance to ANF in salt-depleted rats is independent of sympathetic or ANG-aldosterone systems. The American journal of physiology, 1997, Volume: 272, Issue:4 Pt 2 Topics: Adrenalectomy; Angiotensin Receptor Antagonists; Animals; Atrial Natriuretic Factor; Biphenyl Compounds; Blood Pressure; Denervation; Diet, Sodium-Restricted; Diuresis; Drug Resistance; Electrolytes; Furosemide; Glomerular Filtration Rate; Imidazoles; Kidney; Losartan; Male; Natriuresis; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Reference Values; Sympathectomy, Chemical; Sympathetic Nervous System; Tetrazoles; Time Factors	1997
Role of brain angiotensin in thirst and sodium appetite of rats. Peptides, 1997, Volume: 18, Issue:7 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Appetite; Brain; Drinking; Eating; Furosemide; Imidazoles; Injections, Intraventricular; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Sodium; Sodium, Dietary; Thirst	1997
Studies on nonpeptide angiotensin II receptor antagonists. I. Synthesis and biological evaluation of pyrazolo[1,5-b][1,2,4]triazole derivatives with alkyl substituents. Chemical & pharmaceutical bulletin, 1998, Volume: 46, Issue:1 Topics: Administration, Oral; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Azoles; Biphenyl Compounds; Blood Pressure; Diuretics; Dogs; Dose-Response Relationship, Drug; Female; Furosemide; Losartan; Male; Muscle, Smooth, Vascular; Pyrazoles; Rabbits; Rats; Rats, Wistar; Structure-Activity Relationship; Triazoles	1998
Studies on nonpeptide angiotensin II receptor antagonists. IV. Synthesis and biological evaluation of 4-acrylamide-1H-imidazole derivatives. Chemical & pharmaceutical bulletin, 1998, Volume: 46, Issue:6 Topics: Acrylamides; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Diet, Sodium-Restricted; Disease Models, Animal; Diuretics; Dogs; Female; Furosemide; Hypertension; Imidazoles; Losartan; Male; Prodrugs; Rabbits; Rats; Rats, Wistar; Structure-Activity Relationship; Tetrazoles	1998
Chronic administration of furosemide augments renal weight and glomerular capillary pressure in normal rats. The American journal of physiology, 1998, Volume: 275, Issue:2 Topics: Angiotensin Receptor Antagonists; Animals; Blood Pressure; Body Weight; Capillaries; Furosemide; Glomerular Filtration Rate; Kidney; Kidney Glomerulus; Losartan; Male; Nephrons; Organ Size; Rats; Rats, Wistar	1998
Salt appetite: interaction of forebrain angiotensinergic and hindbrain serotonergic mechanisms. Brain research, 1998, Aug-10, Volume: 801, Issue:1-2 Topics: Angiotensin II; Animals; Appetite; Captopril; Catheterization; Furosemide; Injections, Intraventricular; Injections, Subcutaneous; Losartan; Male; Methysergide; Prosencephalon; Rats; Rats, Sprague-Dawley; Rhombencephalon; Serotonin; Sodium Chloride; Subfornical Organ	1998
In vivo pharmacologic profile of SK-1080, an orally active nonpeptide AT1-receptor antagonist. Journal of cardiovascular pharmacology, 1999, Volume: 33, Issue:3 Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Consciousness; Diastole; Diuretics; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Furosemide; Heart Rate; Hypertension; Hypertension, Renal; Losartan; Male; Pyridines; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles	1999
Pharmacological characterization of KR-30988, a novel non-peptide AT1 receptor antagonist, in rat, rabbit and dog. The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:10 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Dogs; Furosemide; Hypertension, Renal; Imidazoles; Losartan; Male; Oligopeptides; Pressoreceptors; Rabbits; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Recombinant Proteins; Tetrazoles; Vasoconstriction	1999
Activation of renal afferent pathways following furosemide treatment. II. Effect Of angiotensin blockade. Brain research, 2000, Apr-10, Volume: 861, Issue:2 Topics: Afferent Pathways; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Brain Stem; Captopril; Diuretics; Furosemide; Hypothalamus; Hypovolemia; Kidney; Losartan; Male; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Subfornical Organ	2000
Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice. The Journal of clinical investigation, 2001, Volume: 107, Issue:8 Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Enalapril; Furosemide; Guanylate Cyclase; Hydralazine; Losartan; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Myocardium; Organ Size; Propranolol; Receptors, Atrial Natriuretic Factor; Telemetry; Ventricular Dysfunction, Left	2001
[A possible adverse effect from the association of losartan-mefenamic acid in hemodialysis]. Nephrologie, 2001, Volume: 22, Issue:2 Topics: Adult; Antihypertensive Agents; Atenolol; Cyclooxygenase Inhibitors; Drug Interactions; Drug Therapy, Combination; Female; Furosemide; Glomerulonephritis, IGA; Humans; Hypertension; Losartan; Mefenamic Acid; Renal Dialysis	2001
Renal vascular effects of frusemide in the rat: influence of salt loading and the role of angiotensin II. Experimental physiology, 2001, Volume: 86, Issue:5 Topics: Analysis of Variance; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biological Transport; Captopril; Diuretics; Furosemide; Kidney; Kidney Tubules; Laser-Doppler Flowmetry; Losartan; Male; Rats; Rats, Wistar; Renal Circulation; Sodium; Sodium Chloride; Time Factors; Urination; Vasoconstriction	2001
Effect of losartan on sodium appetite of hypothyroid rats subjected to water and sodium depletion and water, sodium and food deprivation. Experimental physiology, 2001, Volume: 86, Issue:5 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Antithyroid Agents; Appetite; Diuretics; Drinking; Eating; Food Deprivation; Furosemide; Hypothyroidism; Losartan; Male; Methimazole; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Sodium Chloride; Water Deprivation	2001
Effect of losartan and furosemide on the urinary excretion of oxypurinol and uric acid. Advances in experimental medicine and biology, 2000, Volume: 486 Topics: Adult; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Proteins; Diuretics; Furosemide; Humans; Losartan; Male; Middle Aged; Oxypurinol; Uric Acid; Xanthine Oxidase	2000
[Acute myocardial failure in a young man: Q-fever myocarditis]. Revista espanola de cardiologia, 2002, Volume: 55, Issue:8 Topics: Acute Disease; Adult; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Antibodies, Bacterial; Cardiomyopathy, Dilated; Clarithromycin; Coxiella burnetii; Diuretics; Echocardiography; Electrocardiography; Follow-Up Studies; Furosemide; Humans; Losartan; Male; Myocarditis; Q Fever; Time Factors	2002
Acute renal failure secondary to angiotensin II receptor blockade in a patient with bilateral renal artery stenosis. Pharmacotherapy, 2003, Volume: 23, Issue:9 Topics: Acute Kidney Injury; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Contraindications; Creatinine; Diabetes Complications; Diabetes Mellitus; Drug Labeling; Emergency Treatment; Furosemide; Humans; Hypertension; Losartan; Male; Middle Aged; Peripheral Vascular Diseases; Receptors, Angiotensin; Renal Artery Obstruction	2003
Effects of subtypes of adrenergic and angiotensinergic antagonists on the water and sodium intake induced by adrenaline injected into the paraventricular nucleus. Brain research, 2003, Dec-24, Volume: 994, Issue:2 Topics: Adrenergic alpha-Antagonists; Angiotensin Receptor Antagonists; Animals; Behavior, Animal; Diuretics; Dose-Response Relationship, Drug; Drinking; Epinephrine; Feeding Behavior; Furosemide; Losartan; Male; Oligopeptides; Paraventricular Hypothalamic Nucleus; Piperazines; Quinazolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary	2003
Chronic angiotensin II AT1 receptor blockade increases cerebral cortical microvessel density. American journal of physiology. Heart and circulatory physiology, 2006, Volume: 290, Issue:2 Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Blood Vessels; Captopril; Cerebral Cortex; Diuretics; Drug Administration Schedule; Drug Combinations; Furosemide; Losartan; Male; Microcirculation; Rats; Rats, Sprague-Dawley; Time Factors	2006
Vasopressin and angiotensin receptors of the medial septal area of the brain in the control of thirst and salt appetite induced by vasopressin in water-deprived and sodium-depleted rats. Pharmacology, biochemistry, and behavior, 2007, Volume: 87, Issue:4 Topics: Animals; Appetite; Brain Chemistry; Diuretics; Drinking; Electrodes, Implanted; Furosemide; Losartan; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Receptors, Vasopressin; Septum of Brain; Sodium; Sodium Chloride, Dietary; Thirst; Vasopressins; Water Deprivation	2007
Oestrogenic influence on brain AT1 receptor signalling on the thirst and sodium appetite in osmotically stimulated and sodium-depleted female rats. Experimental physiology, 2008, Volume: 93, Issue:8 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Brain; Captopril; Contraceptive Agents; Disease Models, Animal; Diuretics; Drinking; Estradiol; Estrogens; Female; Furosemide; Hyponatremia; Losartan; Ovariectomy; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Signal Transduction; Thirst	2008
FURO/CAP: a protocol for sodium intake sensitization. Physiology & behavior, 2010, Mar-30, Volume: 99, Issue:4 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Appetite; Behavior, Animal; Captopril; Diuretics; Dose-Response Relationship, Drug; Drinking; Drug Combinations; Furosemide; Losartan; Male; Rats; Sodium Chloride; Water Deprivation	2010
Effects of commonly administered agents and genetics on nebivolol pharmacokinetics: drug-drug interaction studies. Journal of clinical pharmacology, 2011, Volume: 51, Issue:4 Topics: Adult; Antihypertensive Agents; Benzopyrans; Cytochrome P-450 CYP2D6; Digoxin; Drug Interactions; Ethanolamines; Female; Fluoxetine; Furosemide; Genotype; Humans; Hydrochlorothiazide; Losartan; Male; Middle Aged; Nebivolol; Ramipril; Warfarin; Young Adult	2011
Similar renoprotection after renin-angiotensin-dependent and -independent antihypertensive therapy in 5/6-nephrectomized Ren-2 transgenic rats: are there blood pressure-independent effects? Clinical and experimental pharmacology & physiology, 2010, Volume: 37, Issue:12 Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Creatinine; Diabetic Nephropathies; Diuretics; Drug Therapy, Combination; Furosemide; Hydrochlorothiazide; Hypertension; Indoles; Kidney Failure, Chronic; Labetalol; Losartan; Proteinuria; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Renin; Renin-Angiotensin System	2010
Resistant hypertension responding to change from furosemide to thiazide: understanding calcium channel blocker-related edema. Journal of clinical hypertension (Greenwich, Conn.), 2010, Volume: 12, Issue:12 Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Blood Pressure; Calcium Channel Blockers; Drug Therapy, Combination; Edema; Furosemide; Humans; Hypertension; Losartan; Male; Metoprolol; Sodium Chloride Symporter Inhibitors; Treatment Outcome	2010
AT₁ receptor blockade in the lateral parabrachial nucleus reduces the effects of muscimol on sodium intake. Brain research, 2011, Jul-27, Volume: 1403 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Diuretics; Drinking Behavior; Furosemide; GABA-A Receptor Agonists; Losartan; Male; Muscimol; Pons; Rats; Rats, Wistar; Sodium Chloride	2011
Natriorexigenic effect of baclofen is reduced by AT₁ receptor blockade in the lateral parabrachial nucleus. Brain research bulletin, 2011, Nov-25, Volume: 86, Issue:5-6 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Baclofen; Captopril; Diuretics; Drinking; Drinking Behavior; Furosemide; GABA-B Receptor Agonists; Losartan; Male; Pons; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Sodium Chloride	2011
Involvement of central cholinergic mechanisms on sodium intake induced by gabaergic activation of the lateral parabrachial nucleus. Neuroscience letters, 2013, Feb-08, Volume: 534 Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Atropine; Captopril; Diuretics; Drinking; Eating; Furosemide; GABA Agonists; Imidazoles; Injections, Intraventricular; Losartan; Male; Muscarinic Antagonists; Muscimol; Pons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Muscarinic; Sodium Chloride	2013
Natriorexigenic effect of DAMGO is decreased by blocking AT1 receptors in the central nucleus of the amygdala. Neuroscience, 2014, Mar-14, Volume: 262 Topics: Amygdala; Analgesics, Opioid; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Diuretics; Drinking Behavior; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Furosemide; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Sodium Chloride, Dietary; Time Factors; Water; Water Deprivation	2014
AT1 receptor blockade in the central nucleus of the amygdala attenuates the effects of muscimol on sodium and water intake. Neuroscience, 2015, Oct-29, Volume: 307 Topics: Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Animals; Central Amygdaloid Nucleus; Choice Behavior; Drinking; Furosemide; GABA-A Receptor Agonists; Losartan; Male; Muscimol; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Sodium; Sodium Potassium Chloride Symporter Inhibitors; Time Factors	2015
An association of losartan-hydrochlorothiazide, but not losartan-furosemide, completely arrests progressive injury in the remnant kidney. American journal of physiology. Renal physiology, 2016, Jan-15, Volume: 310, Issue:2 Topics: Albuminuria; Animals; Blood Pressure; Drug Combinations; Furosemide; Hydrochlorothiazide; Hypertension; Kidney; Losartan; Male; Rats; Rats, Wistar; Renal Circulation	2016
Role of protease-activated receptor 2 in regulation of renin synthesis and secretion in mice. Naunyn-Schmiedeberg's archives of pharmacology, 2019, Volume: 392, Issue:11 Topics: Animals; Dose-Response Relationship, Drug; Furosemide; Gene Expression; Hydralazine; Isoproterenol; Kidney; Lipopolysaccharides; Losartan; Male; Mice, Inbred C57BL; Mice, Knockout; Oligopeptides; Receptor, PAR-2; Renin; Sodium Chloride	2019
Applications of shun shell column and nanocomposite sorbent for analysis of eleven anti-hypertensive in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2020, Jun-01, Volume: 1146 Topics: Adsorption; Antihypertensive Agents; Chromatography, High Pressure Liquid; Diltiazem; Furosemide; Humans; Hydrochlorothiazide; Irbesartan; Iron; Labetalol; Limit of Detection; Losartan; Metal Nanoparticles; Methyldopa; Nanocomposites; Polyvinyl Alcohol; Prazosin; Propranolol; Reproducibility of Results; Solid Phase Microextraction; Spironolactone; Valsartan	2020
Sodium palatability in male spontaneously hypertensive rats. Hormones and behavior, 2021, Volume: 130 Topics: Animals; Captopril; Furosemide; Losartan; Male; Rats; Rats, Inbred SHR; Sodium	2021
Occurrence, ecological risk assessment and prioritization of pharmaceuticals and abuse drugs in estuarine waters along the São Paulo coast, Brazil. Environmental science and pollution research international, 2022, Volume: 29, Issue:59 Topics: Acetaminophen; Atenolol; Brazil; Caffeine; Carbamazepine; Chromatography, Liquid; Cocaine; Diclofenac; Ecosystem; Environmental Monitoring; Furosemide; Illicit Drugs; Losartan; Orphenadrine; Pharmaceutical Preparations; Risk Assessment; Rivers; Tandem Mass Spectrometry; Water Pollutants, Chemical	2022