losartan and felodipine

losartan has been researched along with felodipine in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (42.86)18.2507
2000's6 (28.57)29.6817
2010's6 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Abrego, VH; Amaro-Recillas, HA; Angeles, E; Marroquín-Pascual, JL; Martínez, L; Martínez-Pérez, B; Moya-Hernández, R; Rodríguez-Barrientos, D; Rojas-Hernández, A; Rueda-Jackson, JC; Torres, LA1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Goldberg, A; Sweet, C1
Dunlay, MC; Goldberg, AI; Sweet, CS2
Boudier, HA; Daemen, MJ; Nelissen-Vrancken, HJ; Smits, JF1
Chan, JC; Critchley, JA; Goldberg, AI; Lappe, JT; Raskin, SJ; Snavely, D; Sweet, CS1
Chan, JC; Chan, TY; Cockram, CS; Critchley, JA; Tomlinson, B1
Rydén, L; Shimizu, M; Sjöquist, PO; Wang, QD1
Cherng, WJ; Hsieh, IC; Hung, KC; Hung, MJ; Lin, FC; Wang, CH; Wen, MS; Wu, D1
Anguita Sánchez, M1
Aurup, P; Goldberg, A; Oparil, S; Snavely, D1
Kivlighn, S; Ni, ZN; Shahinfar, S; Vaziri, ND; Wang, XQ1
Barth, H; Bolz, SS; Galle, J; Gambaryan, S; Görg, M; Mameghani, A; Pohl, U; Quaschning, T; Raff, U; Seibold, S; Wanner, C1
Boblewski, K; Jurska-Jasko, A; Lehmann, A; Orlewska, C; Rybczynska, A1
Doogue, MP; Miners, JO; Polasek, TM; Rowland, A; Snyder, BD1

Reviews

2 review(s) available for losartan and felodipine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Safety and tolerability of losartan compared with atenolol, felodipine and angiotensin converting enzyme inhibitors.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1995, Volume: 13, Issue:1

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Atenolol; Calcium Channel Blockers; Controlled Clinical Trials as Topic; Cough; Dizziness; Dose-Response Relationship, Drug; Double-Blind Method; Fatigue; Felodipine; Female; Headache; Humans; Hypertension; Incidence; Losartan; Male; Middle Aged; Respiratory Tract Infections

1995

Trials

7 trial(s) available for losartan and felodipine

ArticleYear
Efficacy and safety of losartan.
    The Canadian journal of cardiology, 1995, Volume: 11 Suppl F

    Topics: Antihypertensive Agents; Atenolol; Biphenyl Compounds; Blood Pressure Monitoring, Ambulatory; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation; Enalapril; Felodipine; Humans; Hypertension; Imidazoles; Losartan; Placebos; Tetrazoles

1995
Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension.
    The American journal of cardiology, 1995, Apr-15, Volume: 75, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Asthenia; Atenolol; Biphenyl Compounds; Cough; Dizziness; Double-Blind Method; Fatigue; Felodipine; Female; Headache; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Placebos; Respiratory Tract Infections; Safety; Tetrazoles

1995
Randomised, double-blind, parallel study of the anti-hypertensive efficacy and safety of losartan potassium compared with felodipine ER in elderly patients with mild to moderate hypertension.
    Journal of human hypertension, 1995, Volume: 9, Issue:9

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Biphenyl Compounds; Calcium Channel Blockers; Delayed-Action Preparations; Double-Blind Method; Felodipine; Female; Humans; Hypertension; Imidazoles; Losartan; Male; Tetrazoles; Treatment Outcome

1995
Antihypertensive and anti-albuminuric effects of losartan potassium and felodipine in Chinese elderly hypertensive patients with or without non-insulin-dependent diabetes mellitus.
    American journal of nephrology, 1997, Volume: 17, Issue:1

    Topics: Aged; Albuminuria; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Double-Blind Method; Felodipine; Female; Hong Kong; Humans; Hypertension; Imidazoles; Losartan; Male; Tetrazoles

1997
Comparison of antihypertensive efficacy and tolerability of losartan and extended-release felodipine in patients with mild to moderate hypertension.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 1999, Volume: 98, Issue:6

    Topics: Adult; Aged; Analysis of Variance; Antihypertensive Agents; Delayed-Action Preparations; Felodipine; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Prospective Studies

1999
Efficacy and safety of losartan/hydrochlorothiazide in patients with severe hypertension.
    The American journal of cardiology, 2001, Mar-15, Volume: 87, Issue:6

    Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diuretics; Drug Therapy, Combination; Felodipine; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Sodium Chloride Symporter Inhibitors; Treatment Outcome

2001
Evaluation of felodipine as a potential perpetrator of pharmacokinetic drug-drug interactions.
    European journal of clinical pharmacology, 2014, Volume: 70, Issue:9

    Topics: Adult; Antihypertensive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Calcium Channel Blockers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Felodipine; Female; Genotype; Humans; Losartan; Male; Midazolam; Omeprazole; Young Adult

2014

Other Studies

12 other study(ies) available for losartan and felodipine

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Antihypertensive and antiarrhythmic properties of a para-hydroxy[bis(ortho-morpholinylmethyl)]phenyl-1,4-DHP compound: comparison with other compounds of the same kind and relationship with logP values.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:10

    Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Blood Pressure; Dihydropyridines; Heart Rate; Male; Morpholines; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet

2010
Antihypertensive therapy and adaptive mechanisms in peripheral ischemia.
    Hypertension (Dallas, Tex. : 1979), 1993, Volume: 22, Issue:5

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Capillaries; Captopril; Felodipine; Hindlimb; Iliac Artery; Imidazoles; Ischemia; Losartan; Male; Muscle, Smooth, Vascular; Muscles; Rats; Rats, Inbred SHR; Tetrazoles

1993
Effects of the angiotensin AT1 receptor blocker candesartan on myocardial ischemic/reperfusion injury.
    Journal of the American Society of Nephrology : JASN, 1999, Volume: 10 Suppl 11

    Topics: Angiotensin Receptor Antagonists; Animals; Antioxidants; Benzimidazoles; Biphenyl Compounds; Calcium Channel Blockers; Drug Therapy, Combination; Felodipine; Female; Hemodynamics; In Vitro Techniques; Indoles; Losartan; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Swine; Tetrazoles

1999
[Arterial hypertension and systolic left ventricular dysfunction: therapeutic approach].
    Revista espanola de cardiologia, 1999, Volume: 52 Suppl 3

    Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Carbazoles; Carvedilol; Clinical Trials as Topic; Databases, Bibliographic; Felodipine; Heart Failure; Humans; Hypertension; Hypertrophy, Left Ventricular; Losartan; Meta-Analysis as Topic; Propanolamines; Randomized Controlled Trials as Topic; Risk Factors; Systole; Vasodilator Agents; Ventricular Dysfunction, Left

1999
Effects of aging and AT-1 receptor blockade on NO synthase expression and renal function in SHR.
    Biochimica et biophysica acta, 2002, Oct-21, Volume: 1592, Issue:2

    Topics: Aging; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Calcium Channel Blockers; Felodipine; Hypertension; Kidney; Losartan; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1

2002
Oxidized LDL and its compound lysophosphatidylcholine potentiate AngII-induced vasoconstriction by stimulation of RhoA.
    Journal of the American Society of Nephrology : JASN, 2003, Volume: 14, Issue:6

    Topics: ADP Ribose Transferases; Amides; Angiotensin II; Animals; Aorta; Biological Transport; Cattle; Cells, Cultured; Clostridium; Drug Synergism; Felodipine; Female; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Lipoproteins, LDL; Losartan; Lysophosphatidylcholines; Male; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; rhoA GTP-Binding Protein; Vasoconstriction; Vasoconstrictor Agents

2003
Blockade of calcium channels and AT1 receptor prevents the hypertensive effect of calcilytic NPS 2143 in rats.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2010, Volume: 61, Issue:2

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Calcium Channel Blockers; Calcium Channels; Felodipine; Hypertension; Losartan; Male; Naphthalenes; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Calcium-Sensing

2010