Compounds > losartan

losartan and endothelin-1

losartan has been researched along with endothelin-1 in 91 studies

Research

Studies (91)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's25 (27.47)18.2507
2000's46 (50.55)29.6817
2010's19 (20.88)24.3611
2020's1 (1.10)2.80

Authors

AuthorsStudies
Chua, BH; Chua, CC; Diglio, CA; Siu, BB1
Fareh, J; Schiffrin, EL; Thibault, G; Touyz, RM1
Berrino, L; D'Amico, M; di Filippo, C; Rossi, F1
Leskinen, H; Ruskoaho, H; Vuolteenaho, O1
Becker, K; Brodde, OE; Heinroth-Hoffmann, I; Pönicke, K1
Drexler, H; Ling, BN; Marrero, MB; Schieffer, B1
Borthayre, A; Giaid, A; Haleen, S; Harrison, DG; Keiser, J; Kurz, S; Laursen, JB; Rajagopalan, S1
Danser, AH; Lamers, JM; Saxena, PR; Schalekamp, MA; van Heugten, HA; van Kesteren, CA1
Magga, J; Marttila, M; Ruskoaho, H; Vuolteenaho, O1
Cachofeiro, V; Lahera, V; Maeso, R; Muñoz-Garcia, R; Navarro-Cid, J; Rodrigo, E; Ruilope, LM1
Arnesen, H; Aspelin, T; Kjeldsen, SE; Moan, A; Seljeflot, I; Tønnessen, T1
Beissner, P; Lerch, M; Schneider, M; Shaw, SG; Teuscher, AU; Weidmann, P1
Gardner, DG; Liang, F1
Barton, M; d'Uscio, LV; Lüscher, TF; Shaw, S1
Charlier, AA; Donckier, JE; Heyndrickx, GR; Hodeige, DG; Ketelslegers, JM; Massart, PE; Van Mechelen, H1
Boucher, D; Grose, JH; Kingma, I; Larivière, R; Lebel, M1
Bonn, D1
Boon, NA; Flapan, AD; Fox, KA; Goodfield, NE; Newby, DE; Webb, DJ1
Kawachi, A; Miyashita, M; Motoya, T; Yamada, K1
Alving, K; Oldner, A; Rudehill, A; Rundgren, M; Ullman, J; Wanecek, M; Weitzberg, E1
Baylis, C; Qiu, C1
Hagiwara, Y; Ibusuki, T; Kambe, T; Kubo, T; Saito, E2
Domínguez, J; García-Escribano, JR; Paule, A; Rodríguez-García, JL; Vázquez, M2
D'Amours, M; Grose, JH; Larivière, R; Lebel, M1
Bessard, G; Chavanon, O; Devillier, P; Sessa, C; Stanke-Labesque, F; Tripodi, F1
Baldamus, CA; Marsen, TA; Pollok, M; Sukau, G1
Bohlender, J; Dietz, R; Gerbaulet, S; Gross, M; Kirchengast, M; Krämer, J1
Henrion, D; Lévy, BI; Matrougui, K1
Francisco-DoPrado, J; Gordo, WM; Moreno, H; Sampaio, RC; Tanus-Santos, JE1
Gray, GA; Kenyon, CJ; McEwan, PE; Sherry, L; Webb, DJ1
Ikeda, T; Kawai, N; Kobayashi, T; Miyauchi, T; Nakao, R; Nishikibe, M; Ohta, H; Okada, M; Siegl, PK1
Gopalakrishnan, V; McNeill, JR; Quest, DW; Wilson, TW1
Chiba, S; Fukumori, R; Ibusuki, T; Kambe, T; Kubo, T1
Calaghan, SC; White, E1
Carrier, GO; Catravas, JD; Dimitropoulou, C; Fuchs, L; White, RE; Zhang, H1
Cheng, CP; Cheng, HJ; Igawa, A; Little, WC; Ohte, N; Onishi, K; Suzuki, M; Tachibana, H; Ukai, T; Zhang, ZS1
Bescós, M; Campistol, JM; Campos, B; Iñigo, P; Lario, S; Oppenheimer, F; Piera, C; Rivera, F1
Bescos, M; Campistol, JM; Iñigo, P; Larios, S; Oppenheimer, F1
Crespo, MJ; De Mello, WC1
Bahlmann, L; Heringlake, M; Klaus, S; Pagel, H; Schmucker, P; Wagner, K1
D'Amours, M; Dumont, Y; Larivière, R; Lebel, M1
Asico, LD; Bek, M; Eisner, GM; Goldstein, DS; Grandy, DK; Jose, PA; Li, XX; Rubinstein, M; Yang, Z1
Lüscher, TF1
Bkaily, G; Brochu, I; D'Orléans-Juste, P; Labonté, J1
Gopalakrishnan, V; Liu, P; Misurski, DA1
Deng, SL; Yang, JH; Zhou, QL1
Fan, J; Liu, X; Mi, X; Xu, G; Yang, L1
Capuano, V; Coulombe, A; Deroubaix, E; Ferron, L; Renaud, JF; Ruchon, Y1
Chen, IB; Chen, JJ; Cheng, PY; Cheng, TH; Shih, NL; Wang, DL1
Aiello, EA; Camilión de Hurtado, MC; Cingolani, HE; Dulce, RA; Pérez, NG; Villa-Abrille, MC1
Elena, JV; Grujić-Adanja, G; Jerkić, M; Jovović, D; López-Novoa, JM; Manero, MV; Marković-Lipkovski, J; Mihailović-Stanojević, N; Miloradović, Z; Nastić-Mirić, D; Prieto, MP; Rodríguez-Barbero, A; Vojvodić, SB1
Charles, CJ; Espiner, EA; Frampton, CM; Nicholls, MG; Rademaker, MT; Richards, AM1
Boemke, W; Francis, RC; Höhne, C; Kaczmarczyk, G1
Bogdanska, J; Jovanoska, E; Korneti, P; Kostova, E; Petrov, S; Slaninka-Miceska, M1
Aralica, G; Batelja, L; Blagaic, AB; Hanzevacki, JS; Konjevoda, P; Kusec, V; Lovric-Bencic, M; Rogic, D; Seiwerth, S; Sikiric, P1
Bassagiannis, IC; Douma, SN; Doumas, MN; Petidis, KM; Vogiatzis, KV; Zamboulis, CX1
Chang, NC; Lee, TM; Lin, MS; Tsai, CH1
Barton, M; Catar, RA; Morawietz, H; Muller, G; Niemann, B; Rohrbach, S1
Agharazii, M; Larivière, R; Lavoie, P; Lebel, M; Ledbetter, S; Robitaille, G1
Chen, B; Chen, S; Huang, C; Ji, Z; Liang, C; Sun, W1
Altieri, PI; Crespo, MJ; Escobales, N1
Hussain, T; Siddiqui, AH1
Al Jaroudi, WA; Bikhazi, AB; Bitar, KM; Karam, CN; Maharsy, WM; Nuwayri-Salti, N; Usta, JA1
Li, YQ; Niu, XL; Wang, CX; Wang, SJ; Wei, J; Zhou, J1
Grimm, R; Grisk, O; Klinger, F; Kunert-Keil, C; Rettig, R; Steinbach, A; Tanneberger, M1
Boemke, W; Francis, RC; Höhne, C; Kaisers, U; Klein, A; Pickerodt, P1
Ferrario, CM; Gallagher, PE; Tallant, EA1
Kamata, K; Kobayashi, T; Matsumoto, T; Nogami, T; Taguchi, K1
Agharazii, M; Bélanger, S; Larivière, R; Lebel, M; Lemieux, P; Therrien, F1
Ishida, K; Kamata, K; Kobayashi, T; Matsumoto, T; Taguchi, K1
Albertoni, G; Barreto, JA; Borges, F; Maquigussa, E; Pessoa, E; Schor, N1
Cervenka, L; Husková, Z; Kramer, HJ; Vaněčková, I; Vaňourková, Z1
Hernández-Fonseca, JP; Mosquera, J; Muñoz, M; Pedreañez, A; Rincón, J; Viera, N1
Boyd, R; Ding, LL; Rätsep, MT; Wang, HD1
Huang, Y; Lu, L; Ni, J; Wang, J; Wang, Z; Xue, H; Yao, T; Yu, C; Yuan, P; Zhou, L1
Akhtar, S; Benter, IF; Dhaunsi, GS; Makki, BM; Qabazard, BA; Yousif, MH1
An, SJ; Chai, XQ; Gao, WJ; Liu, P; Lu, HG; Shao, TM1
Apitz, C; Assad, RS; Cho, MY; Friedberg, MK; Honjo, O; Li, J; Redington, AN; Rohailla, S; Sun, M1
Güresir, E; Konczalla, J; Mrosek, J; Platz, J; Schuss, P; Seifert, V; Vatter, H; Wanderer, S1
Adstamongkonkul, P; Bawendi, MG; Boucher, Y; Chauhan, VP; Han, X; Huang, P; Jain, RK; Jain, SR; Kozin, SV; Lacorre, DA; Liu, H; Martin, JD; Mousa, AS; Popović, Z; Stylianopoulos, T1
Aboulkassim, T; Hamel, E; Imboden, H; Lecrux, C; Nicolakakis, N; Ongali, B; Papadopoulos, P; Rosa-Neto, P; Tong, XK1
Chen, CC; Ho, LT; Hsu, YP; Juan, CC; Kwok, CF; Lin, YJ; Shih, KC1
An, SJ; Fu, JQ; Jiao, Z; Li, X; Liu, P; Lu, HG; Shao, TM; Wang, ZJ1
Ahn, YM; Cha, JD; Choi, KM; Kang, DG; Kho, MC; Kim, HY; Lee, HS; Lee, YJ; Park, JH; Park, MC; Tan, R; Yoon, JJ1
Konczalla, J; Mrosek, J; Seifert, V; Vatter, H; Wanderer, S1
Chinen, KT; Donato, AJ; Kronquist, EK; Lesniewski, LA; Li, DY; Reihl, KD; Walker, AE1
Azis, NA; Ismail, NH; Kamal, MSA; Kasim, N; Mohammad Noor, HS; Radjeni, Z; Satar, NA; Singh, H1
Caballero-George, C; Digman, MA; Gratton, E; Planes, N; Vanderheyden, PPML1
Andereggen, L; Kashefiolasl, S; Konczalla, J; Marbacher, S; Mrosek, J; Wanderer, S1

Reviews

2 review(s) available for losartan and endothelin-1

ArticleYear
Role of transforming growth factor-beta1 in the progression of chronic allograft nephropathy.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2001, Volume: 16 Suppl 1

    Topics: Angiotensin II; Antihypertensive Agents; Biomarkers; Disease Progression; Endothelin-1; Humans; Kidney Transplantation; Losartan; Renin-Angiotensin System; Transforming Growth Factor beta; Transplantation, Homologous

2001
Vascular protection: current possibilities and future perspectives.
    International journal of clinical practice. Supplement, 2001, Issue:117

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Arteriosclerosis; Clinical Trials as Topic; Cytokines; Endothelin-1; Endothelium, Vascular; Humans; Losartan; Mice; Mice, Knockout; Nitric Oxide Synthase; Renin-Angiotensin System

2001

Trials

8 trial(s) available for losartan and endothelin-1

ArticleYear
Circulating levels of endothelin-1 during acute hyperinsulinemia in patients with essential hypertension treated with type 1 angiotensin receptor antagonist or placebo.
    Metabolism: clinical and experimental, 1998, Volume: 47, Issue:3

    Topics: Adult; Aged; Antihypertensive Agents; Cross-Over Studies; Double-Blind Method; Endothelin-1; Fasting; Female; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Hyperinsulinism; Hypertension; Kinetics; Losartan; Male; Middle Aged; Placebos

1998
Effects of angiotensin II-receptor blockade with losartan on insulin sensitivity, lipid profile, and endothelin in normotensive offspring of hypertensive parents.
    Journal of cardiovascular pharmacology, 1998, Volume: 31, Issue:4

    Topics: Adult; Angiotensin Receptor Antagonists; Antihypertensive Agents; Cholesterol, HDL; Cross-Over Studies; Double-Blind Method; Drug Tolerance; Endothelin-1; Genetic Predisposition to Disease; Humans; Hypertension; Insulin; Insulin Resistance; Lipoproteins; Losartan; Male; Triglycerides

1998
Regulation of peripheral vascular tone in patients with heart failure: contribution of angiotensin II.
    Heart (British Cardiac Society), 1998, Volume: 80, Issue:2

    Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Endothelin-1; Female; Forearm; Heart Failure; Humans; Infusions, Intra-Arterial; Losartan; Lower Body Negative Pressure; Male; Middle Aged; Norepinephrine; Plethysmography; Regional Blood Flow; Vascular Resistance; Vasoconstrictor Agents

1998
Effect of losartan on angiotensin II-mediated endothelin and prostanoid excretion in humans.
    American journal of hypertension, 2000, Volume: 13, Issue:12

    Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Blood Pressure; Cross-Over Studies; Double-Blind Method; Endothelin-1; Humans; Losartan; Male; Middle Aged; Placebos; Prostaglandins; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin

2000
Effects of losartan and amlodipine on intrarenal hemodynamics and TGF-beta(1) plasma levels in a crossover trial in renal transplant recipients.
    Journal of the American Society of Nephrology : JASN, 2001, Volume: 12, Issue:4

    Topics: Amlodipine; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cross-Over Studies; Endothelin-1; Female; Hemodynamics; Humans; Kidney; Kidney Transplantation; Losartan; Male; Middle Aged; Renal Circulation; Renin; Transforming Growth Factor beta; Transforming Growth Factor beta1

2001
Combined inhibition of angiotensin II and endothelin suppresses the brain natriuretic peptide response to developing heart failure.
    Clinical science (London, England : 1979), 2004, Volume: 106, Issue:6

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Bosentan; Cardiac Output; Cardiac Output, Low; Cardiac Pacing, Artificial; Cyclic GMP; Endothelin Receptor Antagonists; Endothelin-1; Female; Infusions, Parenteral; Losartan; Natriuretic Peptide, Brain; Renin; Sheep; Sulfonamides

2004
Different effects of losartan and moxonidine on endothelial function during sympathetic activation in essential hypertension.
    Journal of clinical hypertension (Greenwich, Conn.), 2004, Volume: 6, Issue:12

    Topics: Angiotensin II Type 1 Receptor Blockers; Biomarkers; Blood Pressure; Catecholamines; Chromatography, High Pressure Liquid; Endothelin-1; Endothelium, Vascular; Exercise Test; Female; Follow-Up Studies; Humans; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Radioimmunoassay; Sympathetic Nervous System; Sympatholytics; Treatment Outcome

2004
Add-on and withdrawal effect of pravastatin on proteinuria in hypertensive patients treated with AT receptor blockers.
    Kidney international, 2005, Volume: 68, Issue:2

    Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Drug Interactions; Drug Resistance; Endothelin-1; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Renal; Lipids; Losartan; Male; Middle Aged; Pravastatin; Proteinuria; Substance Withdrawal Syndrome

2005

Other Studies

81 other study(ies) available for losartan and endothelin-1

ArticleYear
Regulation of endothelin-1 mRNA by angiotensin II in rat heart endothelial cells.
    Biochimica et biophysica acta, 1993, Aug-18, Volume: 1178, Issue:2

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blotting, Northern; Cells, Cultured; Endothelin-1; Endothelins; Endothelium, Vascular; Gene Expression Regulation; Imidazoles; Losartan; Myocardium; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Protein Precursors; Protein Synthesis Inhibitors; Rats; RNA, Messenger; Tetrazoles

1993
Intracellular Ca2+ modulation by angiotensin II and endothelin-1 in cardiomyocytes and fibroblasts from hypertrophied hearts of spontaneously hypertensive rats.
    Hypertension (Dallas, Tex. : 1979), 1996, Volume: 28, Issue:5

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Body Weight; Calcium; Endothelin-1; Fibroblasts; Heart; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Species Specificity; Tetrazoles; Vasoconstrictor Agents; Viper Venoms

1996
Angiotensin II, via an action at AT1 receptors, may modulate the behavioural effects of ET-1 in conscious rats.
    Life sciences, 1996, Volume: 59, Issue:22

    Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Behavior, Animal; Biphenyl Compounds; Drug Synergism; Endothelin-1; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles

1996
Combined inhibition of endothelin and angiotensin II receptors blocks volume load-induced cardiac hormone release.
    Circulation research, 1997, Volume: 80, Issue:1

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atrial Function, Right; Atrial Natriuretic Factor; Biphenyl Compounds; Blood Volume; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hemodynamics; Hormones; Imidazoles; Losartan; Male; Myocardium; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Peptides, Cyclic; Plasma Substitutes; Pressure; Protein Precursors; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetrazoles

1997
Trophic effect of angiotensin II in neonatal rat cardiomyocytes: role of endothelin-1 and non-myocyte cells.
    British journal of pharmacology, 1997, Volume: 121, Issue:1

    Topics: Angiotensin II; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Biphenyl Compounds; Cell Adhesion; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Endothelins; GTP-Binding Proteins; Heart; Imidazoles; Inositol; Inositol Phosphates; Isotope Labeling; Losartan; Myocardium; Peptide Fragments; Peptides, Cyclic; Pertussis Toxin; Phenylalanine; Rats; Rats, Wistar; Tetrazoles; Vasoconstrictor Agents; Virulence Factors, Bordetella

1997
G protein-coupled receptors control vascular smooth muscle cell proliferation via pp60c-src and p21ras.
    The American journal of physiology, 1997, Volume: 272, Issue:6 Pt 1

    Topics: Angiotensin II; Animals; Antibodies; Aorta; Becaplermin; Biphenyl Compounds; Cell Division; Cells, Cultured; DNA; Electroporation; Endothelin-1; GTP-Binding Proteins; Imidazoles; Kinetics; Losartan; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Proto-Oncogene Proteins p21(ras); Proto-Oncogene Proteins pp60(c-src); Rats; Receptors, Angiotensin; Receptors, Cell Surface; Receptors, Endothelin; Receptors, Platelet-Derived Growth Factor; Receptors, Thrombin; Tetrazoles; Thrombin

1997
Role for endothelin-1 in angiotensin II-mediated hypertension.
    Hypertension (Dallas, Tex. : 1979), 1997, Volume: 30, Issue:1 Pt 1

    Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Biphenyl Compounds; Blood Pressure; Dioxoles; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Imidazoles; In Vitro Techniques; Losartan; Male; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Serotonin; Staining and Labeling; Tetrazoles; Time Factors; Vasoconstrictor Agents

1997
Angiotensin II-mediated growth and antigrowth effects in cultured neonatal rat cardiac myocytes and fibroblasts.
    Journal of molecular and cellular cardiology, 1997, Volume: 29, Issue:8

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Cells, Cultured; Endothelin-1; Fibroblasts; Growth Inhibitors; Growth Substances; Heart; Imidazoles; Inositol Phosphates; Losartan; Myocardium; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin

1997
Endothelin-1 is involved in stretch-induced early activation of B-type natriuretic peptide gene expression in atrial but not in ventricular myocytes: acute effects of mixed ET(A)/ET(B) and AT1 receptor antagonists in vivo and in vitro.
    Circulation, 1997, Nov-04, Volume: 96, Issue:9

    Topics: Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Gene Expression Regulation; Losartan; Male; Myocardium; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Perfusion; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; RNA, Messenger; Sulfonamides; Tetrazoles

1997
Losartan reduces constrictor responses to endothelin-1 and the thromboxane A2 analogue in aortic rings from spontaneously hypertensive rats: role of nitric oxide.
    Journal of hypertension, 1997, Volume: 15, Issue:12 Pt 2

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antihypertensive Agents; Aorta, Thoracic; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; Hypertension; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents

1997
Autocrine/paracrine determinants of strain-activated brain natriuretic peptide gene expression in cultured cardiac myocytes.
    The Journal of biological chemistry, 1998, Jun-05, Volume: 273, Issue:23

    Topics: Angiotensin II; Animals; Antibodies; Autocrine Communication; Cells, Cultured; Culture Media, Conditioned; Endothelin-1; Gene Expression Regulation; Genes, Reporter; Humans; Losartan; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Paracrine Communication; Peptides, Cyclic; Promoter Regions, Genetic; Rats; RNA, Messenger; Sprains and Strains; Transfection; Transforming Growth Factor beta; Ventricular Function

1998
Losartan but not verapamil inhibits angiotensin II-induced tissue endothelin-1 increase: role of blood pressure and endothelial function.
    Hypertension (Dallas, Tex. : 1979), 1998, Volume: 31, Issue:6

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Calcium Channel Blockers; Data Interpretation, Statistical; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Hypertension; In Vitro Techniques; Losartan; Male; Muscle, Smooth, Vascular; Nitroprusside; Rats; Rats, Inbred WKY; Receptors, Endothelin; Time Factors; Vasoconstriction; Vasodilation; Vasodilator Agents; Verapamil

1998
Angiotensin II and endothelin-1 receptor antagonists have cumulative hypotensive effects in canine Page hypertension.
    Journal of hypertension, 1998, Volume: 16, Issue:6

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Bosentan; Disease Models, Animal; Dogs; Endothelin Receptor Antagonists; Endothelin-1; Hypertension, Renovascular; Infusions, Intravenous; Losartan; Radioimmunoassay; Receptor, Endothelin A; Sulfonamides; Vascular Resistance

1998
Effects of losartan and captopril on endothelin-1 production in blood vessels and glomeruli of rats with reduced renal mass.
    American journal of hypertension, 1998, Volume: 11, Issue:8 Pt 1

    Topics: Angiotensin II; Animals; Blood Pressure; Blood Vessels; Captopril; Endothelin-1; Kidney Failure, Chronic; Kidney Glomerulus; Losartan; Male; Nephrectomy; Rats; Rats, Sprague-Dawley

1998
Extending the targets for antihypertensive drugs.
    Lancet (London, England), 1998, Aug-01, Volume: 352, Issue:9125

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Endothelin-1; Enzyme Inhibitors; Humans; Losartan; Neprilysin; Renin; Renin-Angiotensin System; Vasopressins

1998
The angiotensin AT1 receptor antagonist, losartan, induces barrel rotation in the rat.
    European journal of pharmacology, 1998, Dec-18, Volume: 363, Issue:2-3

    Topics: Angiotensin Receptor Antagonists; Animals; Endothelin-1; Losartan; Male; Motor Activity; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Endothelin; Receptors, Vasopressin; Vasopressins

1998
Angiotensin II receptor antagonism increases gut oxygen delivery but fails to improve intestinal mucosal acidosis in porcine endotoxin shock.
    Shock (Augusta, Ga.), 1999, Volume: 11, Issue:2

    Topics: Acidosis; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Endothelin-1; Endotoxins; Female; Hemodynamics; Hemoglobins; Intestinal Mucosa; Losartan; Lung; Male; Oxygen; Pulmonary Gas Exchange; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin; Shock, Septic; Splanchnic Circulation; Swine; Urination

1999
Endothelin and angiotensin mediate most glomerular responses to nitric oxide inhibition.
    Kidney international, 1999, Volume: 55, Issue:6

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Kidney Glomerulus; Losartan; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Renal Circulation; Sulfonamides

1999
Vascular mitogen-activated protein kinase activity is enhanced via angiotensin system in spontaneously hypertensive rats.
    European journal of pharmacology, 1999, May-21, Volume: 372, Issue:3

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Endothelin-1; Endothelium, Vascular; Enzyme Activation; Hypertension; Losartan; Male; Peptides, Cyclic; Rats; Rats, Inbred SHR; Rats, Inbred WKY

1999
Effects of the angiotensin II antagonist losartan on endothelin-1 and norepinephrine plasma levels during cold pressor test in patients with chronic heart failure.
    International journal of cardiology, 1999, Aug-31, Volume: 70, Issue:3

    Topics: Aged; Aged, 80 and over; Angiotensin II; Antihypertensive Agents; Blood Pressure; Chronic Disease; Cold Temperature; Endothelin-1; Exercise Test; Female; Heart Failure; Heart Rate; Humans; Losartan; Male; Middle Aged; Norepinephrine; Sympathetic Nervous System; Vasoconstriction

1999
Renal and vascular effects of chronic nitric oxide synthase inhibition: involvement of endothelin 1 and angiotensin II.
    Canadian journal of physiology and pharmacology, 1999, Volume: 77, Issue:1

    Topics: Angiotensin II; Animals; Blood Pressure; Endothelin-1; Enzyme Inhibitors; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley

1999
Antagonistic effects of losartan on thromboxane A2-receptors in human isolated gastroepiploic artery and saphenous vein.
    Journal of cardiovascular pharmacology, 1999, Volume: 34, Issue:5

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelin-1; Humans; In Vitro Techniques; Indomethacin; Losartan; Muscle Contraction; Muscle, Smooth, Vascular; Nitroarginine; Norepinephrine; Potassium Chloride; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Saphenous Vein; Serotonin; Stomach

1999
Enalapril and losartan augment endogenous nitric oxide release in Takayasu's arteritis--a case report.
    Angiology, 2000, Volume: 51, Issue:1

    Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Enalapril; Endothelin-1; Female; Humans; Hypertension, Renovascular; Losartan; Middle Aged; Nephrectomy; Nitric Oxide; Prognosis; Renal Artery Obstruction; Takayasu Arteritis; Vasoconstrictor Agents; Vasodilator Agents

2000
Synergistic effects of AT(1) and ET(A) receptor blockade in a transgenic, angiotensin II-dependent, rat model.
    Hypertension (Dallas, Tex. : 1979), 2000, Volume: 35, Issue:4

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Genetically Modified; Antihypertensive Agents; Blood Pressure; Drug Synergism; Endothelin Receptor Antagonists; Endothelin-1; Humans; Hypertension; Losartan; Phenylpropionates; Pyrimidines; Rats; Renin

2000
Changes in plasma norepinephrine and endothelin levels and metabolic profile after AT1-receptor blockade in human hypertension.
    The American journal of cardiology, 2000, May-01, Volume: 85, Issue:9

    Topics: Aged; Antihypertensive Agents; Endothelin-1; Female; Hemodynamics; Humans; Hypertension; Losartan; Male; Middle Aged; Norepinephrine

2000
Tissue angiotensin II and endothelin-1 modulate differently the response to flow in mesenteric resistance arteries of normotensive and spontaneously hypertensive rats.
    British journal of pharmacology, 2000, Volume: 130, Issue:3

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Viscosity; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Imidazoles; Losartan; Mesenteric Arteries; Muscle Tonus; Perindopril; Phenylpropionates; Pyridines; Pyrimidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Splanchnic Circulation; Vascular Resistance; Vasodilation

2000
Endothelin-1 attenuates bradykinin-induced hypotension in rats.
    European journal of pharmacology, 2000, Jun-02, Volume: 397, Issue:2-3

    Topics: Administration, Oral; Animals; Blood Pressure; Bradykinin; Dose-Response Relationship, Drug; Enalapril; Endothelin-1; Hypotension; Injections, Intravenous; Losartan; Male; Rats; Rats, Wistar

2000
Different activation of vascular mitogen-activated protein kinases in spontaneously and DOCA-salt hypertensive rats.
    European journal of pharmacology, 2000, Jul-21, Volume: 400, Issue:2-3

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Desoxycorticosterone; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Enzyme Activation; Hypertension; In Vitro Techniques; Losartan; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Peptides, Cyclic; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Receptors, Endothelin; Sodium Chloride; Vasoconstrictor Agents

2000
Regulation of the myocardial endothelin system by angiotensin-II and losartan.
    Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:5 Suppl 1

    Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Endothelin-1; Endothelins; Gene Expression Regulation; Losartan; Male; Myocardium; Protein Precursors; Rats; Rats, Wistar; Receptor, Endothelin B; Receptors, Endothelin; RNA, Messenger

2000
Antihypertensive effects of a mixed endothelin-A- and -B-receptor antagonist, J-104132, were augmented in the presence of an AT1 -receptor antagonist, MK-954.
    Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:5 Suppl 1

    Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Drug Synergism; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Losartan; Male; Protein Precursors; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptor, Endothelin A; Receptor, Endothelin B; RNA, Messenger

2000
Mitogen-activated protein kinase activity regulation role of angiotensin and endothelin systems in vascular smooth muscle cells.
    European journal of pharmacology, 2001, Jan-05, Volume: 411, Issue:1-2

    Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Glycopeptides; Losartan; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Pepstatins; Peptides, Cyclic; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Renin

2001
Contribution of angiotensin II, endothelin 1 and the endothelium to the slow inotropic response to stretch in ferret papillary muscle.
    Pflugers Archiv : European journal of physiology, 2001, Volume: 441, Issue:4

    Topics: Angiotensin II; Animals; Endothelin-1; Endothelium; Female; Ferrets; Kinetics; Losartan; Male; Muscle Spindles; Myocardial Contraction; Octoxynol; Oligopeptides; Papillary Muscles; Peptides, Cyclic; Saralasin

2001
Angiotensin II relaxes microvessels via the AT(2) receptor and Ca(2+)-activated K(+) (BK(Ca)) channels.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 37, Issue:2

    Topics: Angiotensin II; Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin-1; Imidazoles; In Vitro Techniques; Losartan; Male; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Nitroarginine; Patch-Clamp Techniques; Peptides; Potassium Channels; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger; Tetraethylammonium; Vasodilation

2001
The role of ANG II and endothelin-1 in exercise-induced diastolic dysfunction in heart failure.
    American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:4

    Topics: Acetamides; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atrial Function, Left; Diastole; Disease Models, Animal; Dogs; Endothelin Receptor Antagonists; Endothelin-1; Heart Failure; Losartan; Nitroprusside; Physical Exertion; Reference Values; Vasodilation; Ventricular Function, Left

2001
Chronic administration of losartan plus hydrochlorothiazide improves vascular status in young cardiomyopathic hamsters.
    European journal of pharmacology, 2001, May-25, Volume: 420, Issue:2-3

    Topics: Acetylcholine; Animals; Antihypertensive Agents; Aorta, Thoracic; Body Weight; Cardiomyopathies; Cricetinae; Dose-Response Relationship, Drug; Drug Synergism; Endothelin-1; Endothelium, Vascular; Hydrochlorothiazide; In Vitro Techniques; Losartan; Male; Mesocricetus; Myocardium; Nitric Oxide; Organ Size; Peptidyl-Dipeptidase A; Vasoconstriction; Vasodilation; Vasodilator Agents

2001
Effects of angiotensin II and the AT(1) receptor antagonist losartan on the renal excretion of urodilatin.
    Kidney & blood pressure research, 2001, Volume: 24, Issue:2

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atrial Natriuretic Factor; Endothelin-1; Glomerular Filtration Rate; Kidney; Losartan; Male; Peptide Fragments; Perfusion; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renal Circulation; Sodium; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents

2001
Blood pressure-independent effect of angiotensin AT1 receptor blockade on renal endothelin-1 production in hypertensive uremic rats.
    Journal of hypertension, 2001, Volume: 19, Issue:8

    Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Endothelin-1; Endothelins; Hypertension; Kidney; Losartan; Male; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Systole; Uremia

2001
Adrenergic and endothelin B receptor-dependent hypertension in dopamine receptor type-2 knockout mice.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:3

    Topics: Adrenergic alpha-Antagonists; Angiotensin Receptor Antagonists; Animals; Antidiuretic Hormone Receptor Antagonists; Antihypertensive Agents; Blood Pressure; Body Weight; Catechols; Endothelin Receptor Antagonists; Endothelin-1; Female; Genotype; Hypertension; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Oligopeptides; Phentolamine; Piperidines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Adrenergic; Receptors, Dopamine D2; Receptors, Endothelin; Sodium; Sodium-Potassium-Exchanging ATPase; Urodynamics; Viper Venoms

2001
Role of endothelin receptors in the hypertensive state of kinin B(2) knockout mice subjected to a high-salt diet.
    Clinical science (London, England : 1979), 2002, Volume: 103 Suppl 48

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Female; Hypertension; Kidney; Losartan; Male; Mice; Mice, Knockout; Myocardium; Oligopeptides; Peptides, Cyclic; Piperidines; Protein Precursors; Receptor, Bradykinin B2; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Angiotensin; Receptors, Bradykinin; Receptors, Endothelin; RNA, Messenger; Sodium Chloride, Dietary

2002
Cysteinyl leukotriene-dependent [Ca2+]i responses to angiotensin II in cardiomyocytes.
    American journal of physiology. Heart and circulatory physiology, 2003, Volume: 284, Issue:4

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Arginine Vasopressin; Benzoquinones; Calcium; Cysteine; Endothelin-1; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Heart; Imidazoles; Inositol 1,4,5-Trisphosphate; Leukotriene C4; Leukotriene D4; Leukotrienes; Lipoxygenase Inhibitors; Losartan; Myocardium; Propionates; Pyridines; Quinolines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Spectrometry, Fluorescence

2003
[Effects of angiotension II receptor antagonist on the level ET and NO in the patients with renal hypertension and protection of renal function].
    Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, 2001, Dec-28, Volume: 26, Issue:6

    Topics: Adult; Angiotensin Receptor Antagonists; Endothelin-1; Female; Glomerulonephritis; Humans; Hypertension, Renal; Kidney Function Tests; Losartan; Male; Middle Aged; Nitric Oxide

2001
[Protective effect of angiotensin II receptor blockage on rats with experimental diabetes nephropathy in early stage].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2003, Volume: 34, Issue:2

    Topics: Angiotensin Receptor Antagonists; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Endothelin-1; Kidney Function Tests; Losartan; Male; Rats; Rats, Wistar

2003
Angiotensin II signaling pathways mediate expression of cardiac T-type calcium channels.
    Circulation research, 2003, Dec-12, Volume: 93, Issue:12

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Bosentan; Butadienes; Calcium Channels, T-Type; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Constriction, Pathologic; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Flavonoids; Gene Expression; Losartan; Male; Membrane Potentials; Mitogen-Activated Protein Kinase Kinases; Myocytes, Cardiac; Nickel; Nitriles; Oligopeptides; Peptides, Cyclic; Piperidines; Rats; Rats, Wistar; Receptors, Angiotensin; Receptors, Endothelin; RNA, Messenger; Signal Transduction; Sulfonamides

2003
Involvement of reactive oxygen species in angiotensin II-induced endothelin-1 gene expression in rat cardiac fibroblasts.
    Journal of the American College of Cardiology, 2003, Nov-19, Volume: 42, Issue:10

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Azepines; Cell Culture Techniques; Cell Division; Endothelin Receptor Antagonists; Endothelin-1; Fibroblasts; Gene Expression; Heart; Losartan; Mitogen-Activated Protein Kinases; Oligopeptides; Oxidation-Reduction; Rats; Reactive Oxygen Species; Receptors, Angiotensin; Receptors, Endothelin; Signal Transduction; Up-Regulation

2003
A low dose of angiotensin II increases inotropism through activation of reverse Na(+)/Ca(2+) exchange by endothelin release.
    Cardiovascular research, 2003, Dec-01, Volume: 60, Issue:3

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cats; Electrophysiology; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Glycopeptides; Guanidines; In Vitro Techniques; Losartan; Muscle Contraction; Papillary Muscles; Patch-Clamp Techniques; Peptides, Cyclic; Sodium-Calcium Exchanger; Sulfones; Thiourea

2003
Relative roles of endothelin-1 and angiotensin II in experimental post-ischaemic acute renal failure.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19, Issue:1

    Topics: Acute Kidney Injury; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Infusions, Intravenous; Kidney; Losartan; Male; Models, Animal; Rats; Rats, Wistar; Reperfusion Injury; Sulfonamides

2004
Effect of angiotensin II and endothelin-1 receptor blockade on the haemodynamic and hormonal changes after acute blood loss and after retransfusion in conscious dogs.
    Acta physiologica Scandinavica, 2004, Volume: 180, Issue:4

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Atrasentan; Blood Pressure; Blood Transfusion; Cardiac Output; Dogs; Endothelin-1; Epinephrine; Female; Glomerular Filtration Rate; Hemodynamics; Hemorrhage; Losartan; Norepinephrine; Pyrrolidines; Receptor, Endothelin A; Stroke Volume; Urine; Vascular Resistance; Vasopressins

2004
Effect of angiotensin II type 1 (AT1) receptor antagonist on the endothelial dysfunction in spontaneously hypertensive rats in correlation with the nitric oxide system.
    Bratislavske lekarske listy, 2003, Volume: 104, Issue:11

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Cyclic GMP; Endothelin-1; Endothelium, Vascular; Hypertension; Losartan; Nitric Oxide; Rats; Rats, Inbred SHR

2003
Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse.
    Journal of pharmacological sciences, 2004, Volume: 95, Issue:1

    Topics: Amlodipine; Animals; Doxorubicin; Endothelin-1; Gastric Mucosa; Heart Failure; Losartan; Male; Mice; Peptide Fragments; Peptides; Proteins; Rats; Rats, Wistar; Stomach

2004
Native and oxidized low-density lipoproteins stimulate endothelin-converting enzyme-1 expression in human endothelial cells.
    Biochemical and biophysical research communications, 2005, Sep-02, Volume: 334, Issue:3

    Topics: Aspartic Acid Endopeptidases; Cells, Cultured; Endothelial Cells; Endothelin-1; Endothelin-Converting Enzymes; Humans; Indoles; Lipoproteins, LDL; Losartan; Metalloendopeptidases; Oxidation-Reduction; Protein Kinase C; Protein Precursors; RNA, Messenger

2005
Neutralization of transforming growth factor-beta attenuates hypertension and prevents renal injury in uremic rats.
    Journal of hypertension, 2005, Volume: 23, Issue:10

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antibodies; Aorta, Thoracic; Blood Pressure; Blotting, Northern; Blotting, Western; Creatinine; Endothelin-1; Gene Expression; Hypertension; Kidney; Losartan; Male; Neutralization Tests; Proteinuria; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta; Uremia

2005
Protective effects of blocking renin-angiotensin system on the progression of renal injury in glomerulosclerosis.
    Cellular & molecular immunology, 2005, Volume: 2, Issue:2

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Base Sequence; Benzazepines; Collagen Type IV; DNA, Complementary; Endothelin-1; Fibronectins; Glomerulosclerosis, Focal Segmental; Kidney; Losartan; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; RNA, Messenger; Transforming Growth Factor beta; Transforming Growth Factor beta1

2005
Increased vascular angiotensin II binding capacity and ET-1 release in young cardiomyopathic hamsters.
    Vascular pharmacology, 2006, Volume: 44, Issue:4

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Binding, Competitive; Cardiomyopathies; Cricetinae; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin-1; In Vitro Techniques; Losartan; Male; Mesocricetus; Peptides, Cyclic; Protein Binding; Receptor, Angiotensin, Type 1; Receptor, Endothelin A; Vasoconstriction; Vasoconstrictor Agents

2006
Enhanced AT1 receptor-mediated vasocontractile response to ANG II in endothelium-denuded aorta of obese Zucker rats.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 292, Issue:4

    Topics: Acetylcholine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Body Weight; Endothelial Cells; Endothelin-1; Enzyme Inhibitors; In Vitro Techniques; Losartan; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Nitroprusside; Obesity; Potassium Chloride; Rats; Rats, Zucker; Receptor, Angiotensin, Type 1; RNA, Messenger; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents

2007
Effect of type-1 diabetes mellitus on the regulation of insulin and endothelin-1 receptors in rat hearts.
    Canadian journal of physiology and pharmacology, 2007, Volume: 85, Issue:2

    Topics: Animals; Blotting, Western; Diabetes Mellitus, Type 1; Endothelin-1; Fluorescent Antibody Technique; Losartan; Male; Myocardium; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Receptor, Insulin

2007
[Peroxisome proliferator-activated receptor activator troglitazone inhibits angiotensin II-stimulated secretion of vasoactive factors by endothelial cells].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2007, Volume: 27, Issue:7

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Cell Line; Chromans; Dose-Response Relationship, Drug; Endothelial Cells; Endothelin-1; Gene Expression Regulation; Humans; Hypertension; Immunohistochemistry; Losartan; Nitric Oxide; PPAR gamma; Receptor, Angiotensin, Type 1; Thiazolidinediones; Troglitazone

2007
Low NaCl intake elevates renal medullary endothelin-1 and endothelin A (ETA) receptor mRNA but not the sensitivity of renal Na+ excretion to ETA receptor blockade in rats.
    Acta physiologica (Oxford, England), 2008, Volume: 192, Issue:3

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Gene Expression; Kidney Medulla; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Renal Circulation; RNA, Messenger; Sodium; Sodium Chloride, Dietary

2008
ETA-receptor blockade impairs vasoconstriction after hemorrhage in xenon-anesthetized dogs treated with an AT1-receptor antagonist.
    Canadian journal of physiology and pharmacology, 2008, Volume: 86, Issue:6

    Topics: Anesthesia; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Atrasentan; Blood Pressure; Dogs; Endothelin A Receptor Antagonists; Endothelin-1; Female; Hemodynamics; Hemorrhage; Losartan; Pyrrolidines; Vascular Resistance; Vasoconstriction; Vasopressins; Xenon

2008
Regulation of ACE2 in cardiac myocytes and fibroblasts.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:6

    Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Animals, Newborn; Atrial Natriuretic Factor; Butadienes; Cells, Cultured; Endothelin-1; Fibroblasts; Flavonoids; Gene Expression Regulation, Enzymologic; Heart Ventricles; Losartan; Mitogen-Activated Protein Kinase 1; Myocytes, Cardiac; Nitriles; Peptide Fragments; Peptidyl-Dipeptidase A; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction

2008
Diabetic state, high plasma insulin and angiotensin II combine to augment endothelin-1-induced vasoconstriction via ETA receptors and ERK.
    British journal of pharmacology, 2008, Volume: 155, Issue:7

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Endothelin A Receptor Antagonists; Endothelin-1; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Hypertension; Insulin; Losartan; Male; Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Receptor, Endothelin A; Streptozocin; Vasoconstriction

2008
Protective effects of angiotensin AT1 receptor blockade in malignant hypertension in the rat.
    European journal of pharmacology, 2009, Apr-01, Volume: 607, Issue:1-3

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Atrasentan; Blood Pressure; Endothelin-1; Hydralazine; Hypertension, Malignant; Losartan; Male; Necrosis; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renal Insufficiency

2009
Short-term angiotensin-1 receptor antagonism in type 2 diabetic Goto-Kakizaki rats normalizes endothelin-1-induced mesenteric artery contraction.
    Peptides, 2010, Volume: 31, Issue:4

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Endothelin-1; Insulin; Losartan; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Rats; Rats, Mutant Strains; Rats, Wistar; Receptor, Angiotensin, Type 1

2010
Soluble uric acid increases intracellular calcium through an angiotensin II-dependent mechanism in immortalized human mesangial cells.
    Experimental biology and medicine (Maywood, N.J.), 2010, Volume: 235, Issue:7

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Calcium; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Humans; Losartan; Mesangial Cells; Polymerase Chain Reaction; Uric Acid

2010
Despite similar reduction of blood pressure and renal ANG II and ET-1 levels aliskiren but not losartan normalizes albuminuria in hypertensive Ren-2 rats.
    Physiological research, 2010, Volume: 59, Issue:3

    Topics: Albuminuria; Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Down-Regulation; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Fumarates; Hypertension; Kidney; Losartan; Male; Mice; Pilot Projects; Radioimmunoassay; Rats; Rats, Transgenic; Renin; Time Factors

2010
Proinflammatory role of angiotensin II in a rat nephrosis model induced by adriamycin.
    Journal of the renin-angiotensin-aldosterone system : JRAAS, 2011, Volume: 12, Issue:4

    Topics: Angiotensin II; Animals; Cholesterol; Disease Models, Animal; Doxorubicin; Endothelin-1; Fluorescent Antibody Technique; Inflammation; Inflammation Mediators; Kidney; Losartan; Male; Nephrosis; Proteinuria; Rats; Rats, Sprague-Dawley; Time Factors; Triglycerides; Weight Gain

2011
ETA and ETB receptors are expressed in vascular adventitial fibroblasts.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 301, Issue:6

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Blotting, Western; Cells, Cultured; Collagen Type I; Connective Tissue; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Losartan; Mice; Oligopeptides; Peptides, Cyclic; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; Time Factors; Viper Venoms

2011
Counteraction between angiotensin II and angiotensin-(1-7) via activating angiotensin type I and Mas receptor on rat renal mesangial cells.
    Regulatory peptides, 2012, Aug-20, Volume: 177, Issue:1-3

    Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blotting, Western; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Interactions; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Glomerular Mesangium; Imidazoles; Losartan; MAP Kinase Signaling System; Mesangial Cells; Microscopy, Confocal; Peptide Fragments; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pyridines; Rats; Real-Time Polymerase Chain Reaction; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Receptors, G-Protein-Coupled; Transforming Growth Factor beta1

2012
Characterization of Angiotensin-(1-7) effects on the cardiovascular system in an experimental model of type-1 diabetes.
    Pharmacological research, 2012, Volume: 66, Issue:3

    Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Captopril; Cardiovascular System; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Endothelin-1; Hyperglycemia; Kidney; Losartan; Male; NADPH Oxidases; Peptide Fragments; Peptides; Peptidyl-Dipeptidase A; Prostaglandins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Reperfusion Injury

2012
[Effects of angiotensin II and its receptor blockers on migration and endothelin-1 expression of rat vascular adventitial fibroblast subpopulations].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2012, Volume: 47, Issue:11

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cell Movement; Cells, Cultured; Endothelin-1; Fibroblasts; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Vasoconstrictor Agents

2012
Adverse biventricular remodeling in isolated right ventricular hypertension is mediated by increased transforming growth factor-β1 signaling and is abrogated by angiotensin receptor blockade.
    American journal of respiratory cell and molecular biology, 2013, Volume: 49, Issue:6

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Connective Tissue Growth Factor; Endothelin-1; Familial Primary Pulmonary Hypertension; Fibrosis; Hypertension; Hypertension, Pulmonary; Losartan; Male; Matrix Metalloproteinase 2; Rabbits; Receptor, Endothelin B; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta1; Ventricular Dysfunction, Right; Ventricular Remodeling

2013
Crosstalk between the angiotensin and endothelin-system in the cerebrovasculature.
    Current neurovascular research, 2013, Volume: 10, Issue:4

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensins; Animals; Basilar Artery; Cell Communication; Endothelin-1; Losartan; Male; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilation; Vasospasm, Intracranial

2013
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels.
    Nature communications, 2013, Volume: 4

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensins; Animals; Antineoplastic Agents; Cell Hypoxia; Collagen; Connective Tissue Growth Factor; Drug Repositioning; Drug Synergism; Endothelin-1; Female; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Hyaluronic Acid; Losartan; Mammary Neoplasms, Experimental; Mechanotransduction, Cellular; Mice; Pancreatic Neoplasms; Receptor, Angiotensin, Type 1; Stress, Mechanical; Stromal Cells; Transforming Growth Factor beta1

2013
Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer's disease model.
    Neurobiology of disease, 2014, Volume: 68

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Angiotensin II Type 1 Receptor Blockers; Animals; Arginine; Blood Pressure; Brain; Cerebrovascular Circulation; Cognition Disorders; Disease Models, Animal; Endothelin-1; Enzyme Inhibitors; Female; Gene Expression Regulation; Humans; Losartan; Male; Mice; Mice, Transgenic; Mutation

2014
Angiotensin II enhances endothelin-1-induced vasoconstriction through upregulating endothelin type A receptor.
    Biochemical and biophysical research communications, 2014, Aug-22, Volume: 451, Issue:2

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Aorta, Thoracic; Cell Line; Endothelin-1; Imidazoles; Losartan; Male; MAP Kinase Signaling System; Myocytes, Smooth Muscle; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Up-Regulation; Vasoconstriction

2014
Characterization and functions of vascular adventitial fibroblast subpopulations.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 35, Issue:3

    Topics: Adventitia; Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Aorta, Thoracic; Cell Lineage; Cell Movement; Cell Proliferation; Cells, Cultured; Collagen Type I; Endothelin-1; Fibroblasts; Imidazoles; Losartan; Male; Pyridines; Rats; RNA, Messenger

2015
Fermented Red Ginseng Potentiates Improvement of Metabolic Dysfunction in Metabolic Syndrome Rat Models.
    Nutrients, 2016, Jun-16, Volume: 8, Issue:6

    Topics: Adipocytes; Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Glucose; Blood Pressure; Body Weight; Cholesterol, HDL; Cholesterol, LDL; Disease Models, Animal; Down-Regulation; Endothelin-1; Fermentation; Fructose; Glucose Transporter Type 4; Insulin Receptor Substrate Proteins; Liver; Losartan; Metabolic Syndrome; Obesity; Organ Size; Panax; Phytotherapy; Plant Preparations; Rats; Triglycerides; Up-Regulation

2016
Crosstalk between the angiotensin and endothelin system in the cerebrovasculature after experimental induced subarachnoid hemorrhage.
    Neurosurgical review, 2018, Volume: 41, Issue:2

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensins; Animals; Basilar Artery; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Losartan; Male; Oligopeptides; Peptides, Cyclic; Piperidines; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Subarachnoid Hemorrhage; Vasoconstriction; Vasodilation; Vasospasm, Intracranial

2018
Cerebral and skeletal muscle feed artery vasoconstrictor responses in a mouse model with greater large elastic artery stiffness.
    Experimental physiology, 2019, Volume: 104, Issue:3

    Topics: Angiotensin II; Animals; Cerebral Arteries; Disease Models, Animal; Endothelin-1; Endothelium, Vascular; Losartan; Male; Mice; Muscle, Skeletal; Norepinephrine; Receptor, Angiotensin, Type 1; Vascular Stiffness; Vasoconstriction; Vasoconstrictor Agents

2019
Standardized ethanol-water extract of Ficus deltoidea Angustifolia reduces blood pressure in spontaneously hypertensive rats.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2019, Volume: 41, Issue:5

    Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Calcium; Endothelin-1; Ethanol; Ficus; Heart Rate; Hypertension; Losartan; Male; Myocardium; Organ Size; Phytotherapy; Plant Extracts; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Water

2019
Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT
    Biochimica et biophysica acta. General subjects, 2019, Volume: 1863, Issue:5

    Topics: Angiotensin II; Animals; Binding Sites; CHO Cells; Cricetulus; Endothelin-1; Fluorescence Resonance Energy Transfer; Humans; Isoxazoles; Ligands; Losartan; Peptides, Cyclic; Protein Aggregates; Receptor, Endothelin A; Thiophenes

2019
The Role of Losartan as a Potential Neuroregenerative Pharmacological Agent after Aneurysmal Subarachnoid Haemorrhage.
    International journal of molecular sciences, 2020, Sep-05, Volume: 21, Issue:18

    Topics: Animals; Basilar Artery; Disease Models, Animal; Endothelin-1; Losartan; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B; Regenerative Medicine; Subarachnoid Hemorrhage; Vasoconstriction; Vasodilation; Vasodilator Agents; Vasospasm, Intracranial

2020