losartan and enalaprilat anhydrous

losartan has been researched along with enalaprilat anhydrous in 61 studies

Research

Studies (61)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	33 (54.10)	18.2507
2000's	18 (29.51)	29.6817
2010's	9 (14.75)	24.3611
2020's	1 (1.64)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Avdeef, A; Tam, KY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Beierwaltes, WH; Carretero, OA; Sigmon, DH	1
Carmines, PK; Inscho, EW; Navar, LG; Ohishi, K	1
Bunting, PB; Cartwright, ME; Frank, JD; Gibson, RE; Schorn, TW; Siegl, PK; Thorpe, HH	1
Mah, SC; Schnell, C; Wood, JM	1
Boutinet, S; Fleetwood, G; Meier, M; Wood, JM	1
Chen, C; Lokhandwala, MF	1
Kunert-Radek, J; Mucha, S; Pawlikowski, M; Pisarek, H; Sepien, H; Stawowy, A	1
Arnet, U; Lüscher, TF; Siebenmann, R; Turina, M; von Segesser, L; Yang, Z	1
Berdeaux, A; Giudicelli, JF; Richard, V	1
Caride, VJ; Fernandez, LA; Näveri, L; Strömberg, C; Wicke, JD	1
Cumin, F; De Gasparo, M; Levens, N; Macari, D; Whitebread, S	1
Madwed, JB; Winquist, RJ	1
Feng, CJ; Kadowitz, PJ; Nossaman, BD; Wang, J	1
Castillo, G; Esteban, S; Orce, G	1
Berdeaux, A; Ghaleh, B; Giudicelli, JF; Richard, V	1
Barbant, SD; Chatterjee, K; Gupta, M; MacGregor, JS; Redberg, R; Sudhir, K; Yock, PG	1
Cupples, WA	1
Mimran, A; Nafrialdi, N; Ribstein, J; Valentin, JP	1
Buckman, S; Burns, KD; Iacovitti, M; Levine, DZ	1
de Champlain, J; Foucart, S; Oster, L; Patrick, SK	1
Arendshorst, WJ; Chatziantoniou, C; Kurtz, A; Ruan, X; Wagner, C	1
Armentano, RL; Barra, JG; Cabrera Fischer, EI; Levenson, J; Pichel, RH; Simon, A	1
Cardinal, R; de Champlain, J; K-Laflamme, A; Oster, L	1
Baum, M; Quan, A	1
Baum, M; Quan, A; Quigley, R	1
Adam, A; Blais, C; Drapeau, G; Gervais, N; Lamontagne, D; Raymond, P; Venneman, I	1
Fleischhauer, J; Hanrath, P; Klues, HG; Montino, H; Schwarz, ER; vom Dahl, J	1
Cardinal, R; de Champlain, J; Foucart, S; K-Laflamme, A; Lambert, C; Moreau, P	1
Gaudet, EA; Godwin, SJ; Head, GA	1
Gelpi, RJ; Morales, C; Rodríguez, M; Scapín, O	1
Angus, JA; Whorlow, SL; Wright, CE	1
Barbe, F; Crozatier, B; Guyene, TT; Hittinger, L; Houël, R; Su, J	1
Janssen, BJ; Oosting, J; Struijker-Boudier, HA	1
Danser, AH; Kroon, I; Saris, JJ; Schalekamp, MA; van Dijk, MA	1
Hayashi, Y; Hisa, H; Satoh, S; Suzuki-Kusaba, M; Yamaguchi, N; Yoshida, M	1
Kingma, JG; Rouleau, JR; Simard, D	1
Connell, JM; Hillier, C; McDonald, JE; McMurray, JJ; Padmanabhan, N; Petrie, MC	1
Fetics, B; Hare, JM; Kass, DA; Maughan, WL; Pak, PH; Wittstein, IS	1
Clanachan, AS; Dyck, JR; Ford, WR; Jugdutt, BI; Kumar, D; Lopaschuk, GD; Xu, Y	1
Doverspike, A; Hentosz, T; Huerbin, R; Nikolaidis, LA; Shannon, RP	1
Epelde, F; Heras, M; Pérez-Villa, F; Rigol, M; Roig, E; Roqué, M; Sanz, G; Solanes, N	1
De Mello, WC	1
Clanachan, AS; Ford, WR; Jugdutt, BI; Kumar, D; Menon, V	1
Beier, K; Bellahcene, M; Buser, PT; Butz, S; Driamov, S; Remondino, A; Zaugg, CE; Ziegler, A	1
De Mello, WC; Monterrubio, J	1
Adler, S; Huang, H	1
Padilha, AS; Rossoni, LV; Vassallo, DV; Xavier, FE	1
Abassi, Z; Assady, S; Khankin, E; Kositch, Z; Lewin, M; Nakhoul, F; Ramadan, R; Yaccob, A	1
Liu, LY; Liu, YH; Song, T; Wu, SJ; You, Y	1
Angeli, JK; Casali, EA; Fürstenau, CR; Ramos, DB; Sarkis, JJ; Souza, DO; Stefanon, I; Vassallo, DV	1
Huang, YS; Shi, XH; Teng, M; Xiao, R; Zhang, Q	1
Kang, YM; Qi, J; Qin, DN; Su, Q; Suo, YP; Yang, Q; Yu, XJ; Yue, LY; Zhang, DM; Zhu, GQ	1
Hillfinger, J; Larsen, SD; Lipka, E; Okawada, M; Teitelbaum, DH; Wilson, MW	1
Astori, G; Bernardi, M; Bozza, A; Catanzaro, D; Chieregato, K; Merlo, A	1

Reviews

2 review(s) available for losartan and enalaprilat anhydrous

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Regulation of proximal tubule transport by angiotensin II. Seminars in nephrology, 1997, Volume: 17, Issue:5 Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biological Transport; Enalaprilat; Homeostasis; Kidney Tubules, Proximal; Losartan; Rats; Receptors, Angiotensin; Renin-Angiotensin System	1997

Trials

1 trial(s) available for losartan and enalaprilat anhydrous

Article	Year
Functional importance of angiotensin-converting enzyme-dependent in situ angiotensin II generation in the human forearm. Hypertension (Dallas, Tex. : 1979), 2000, Volume: 35, Issue:3 Topics: Adolescent; Adult; Aged; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Brachial Artery; Enalaprilat; Endothelium, Vascular; Forearm; Humans; Losartan; Male; Middle Aged; Peptidyl-Dipeptidase A; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Regional Blood Flow; Vasoconstriction	2000

Article

Year

Functional importance of angiotensin-converting enzyme-dependent in situ angiotensin II generation in the human forearm.

Hypertension (Dallas, Tex. : 1979), 2000, Volume: 35, Issue:3

Topics: Adolescent; Adult; Aged; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Brachial Artery; Enalaprilat; Endothelium, Vascular; Forearm; Humans; Losartan; Male; Middle Aged; Peptidyl-Dipeptidase A; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Regional Blood Flow; Vasoconstriction

2000

Other Studies

58 other study(ies) available for losartan and enalaprilat anhydrous

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Angiotensin dependence of endothelium-mediated renal hemodynamics. Hypertension (Dallas, Tex. : 1979), 1992, Volume: 20, Issue:5 Topics: Angiotensin II; Animals; Arginine; Biphenyl Compounds; Blood Pressure; Enalaprilat; Endothelium, Vascular; Hemodynamics; Imidazoles; Kinins; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Circulation; Tetrazoles	1992
EDRF-angiotensin II interactions in rat juxtamedullary afferent and efferent arterioles. The American journal of physiology, 1992, Volume: 263, Issue:5 Pt 2 Topics: Acetylcholine; Angiotensin II; Animals; Arginine; Arterioles; Biphenyl Compounds; Drug Interactions; Enalaprilat; Imidazoles; In Vitro Techniques; Kidney Medulla; Losartan; Male; Nitric Oxide; Nitroarginine; Osmolar Concentration; Rats; Renal Circulation; Tetrazoles; Vasoconstriction	1992
Angiotensin II receptor subtypes in renal cortex of rats and rhesus monkeys. The American journal of physiology, 1991, Volume: 261, Issue:3 Pt 2 Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding, Competitive; Biphenyl Compounds; Blood Pressure; Enalaprilat; Heart Rate; Imidazoles; Iodine Radioisotopes; Kidney Cortex; Losartan; Macaca mulatta; Male; Pyridines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Renin; Tetrazoles	1991
Comparison of the acute hypotensive effects of renin inhibition, converting enzyme inhibition, and angiotensin II antagonism in rats. Journal of cardiovascular pharmacology, 1990, Volume: 16 Suppl 4 Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Analysis of Variance; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Enalaprilat; Hypertension; Hypertension, Renal; Imidazoles; Losartan; Oligopeptides; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Renin; Time Factors	1990
Involvement of the renin-angiotensin system in ischemic damage and reperfusion arrhythmias in the isolated perfused rat heart. Journal of cardiovascular pharmacology, 1991, Volume: 17, Issue:3 Topics: Animals; Arrhythmias, Cardiac; Creatine Kinase; Enalaprilat; Imidazoles; In Vitro Techniques; Losartan; Male; Myocardial Reperfusion Injury; Oligopeptides; Perfusion; Rats; Rats, Inbred Strains; Renin-Angiotensin System; Tetrazoles	1991
Potentiation by enalaprilat of fenoldopam-evoked natriuresis is due to blockade of intrarenal production of angiotensin-II in rats. Naunyn-Schmiedeberg's archives of pharmacology, 1995, Volume: 352, Issue:2 Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Bradykinin; Diuresis; Dopamine Agonists; Drug Synergism; Enalaprilat; Fenoldopam; Glomerular Filtration Rate; Imidazoles; Kidney; Losartan; Male; Natriuresis; Rats; Rats, Sprague-Dawley; Tetrazoles	1995
Is estrogen-induced pituitary hyperplasia and hyperprolactinaemia mediated by angiotensin II? Advances in experimental medicine and biology, 1995, Volume: 377 Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Cell Division; Diethylstilbestrol; Enalapril; Enalaprilat; Estrogens; Estrogens, Non-Steroidal; Humans; Hyperpituitarism; Hyperplasia; Hyperprolactinemia; Imidazoles; Losartan; Prolactin; Pyridines; Rats; Rats, Inbred F344; Rats, Wistar; Tetrazoles; Tumor Cells, Cultured	1995
Different effects of angiotensin-converting enzyme inhibition in human arteries and veins. Journal of cardiovascular pharmacology, 1993, Volume: 22 Suppl 5 Topics: Acetylcholine; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Compounds; Bradykinin; Enalaprilat; Endothelium, Vascular; Humans; Imidazoles; In Vitro Techniques; Losartan; Mammary Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Saphenous Vein; Tetrazoles	1993
Systemic and coronary effects of the angiotensin II receptor antagonist EXP3174 in dogs. Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:1 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Coronary Circulation; Dogs; Enalaprilat; Female; Furosemide; Hemodynamics; Imidazoles; Losartan; Male; Renin-Angiotensin System; Tetrazoles	1993
Angiotensin AT2 receptor stimulation increases survival in gerbils with abrupt unilateral carotid ligation. Journal of cardiovascular pharmacology, 1994, Volume: 24, Issue:6 Topics: Animals; Biphenyl Compounds; Brain Ischemia; Carotid Arteries; Dose-Response Relationship, Drug; Drug Interactions; Enalaprilat; Gerbillinae; Imidazoles; Ligation; Losartan; Male; Pyridines; Receptors, Angiotensin; Regional Blood Flow; Survival Analysis; Tetrazoles	1994
Renal actions of the angiotensin AT2 receptor ligands CGP 42112 and PD 123319 after blockade of the renin-angiotensin system. European journal of pharmacology, 1994, Jun-23, Volume: 259, Issue:1 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Enalaprilat; Imidazoles; Kidney; Losartan; Male; Oligopeptides; Pyridines; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Tetrazoles; Vascular Resistance	1994
Effects of losartan (DuP753) and enalaprilat on the mean arterial pressure response to phenylephrine. Journal of hypertension, 1994, Volume: 12, Issue:2 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Enalaprilat; Heart Rate; Imidazoles; Infusions, Intravenous; Losartan; Phenylephrine; Rabbits; Renin-Angiotensin System; Tetrazoles	1994
Analysis of angiotensins I, II, and III in pulmonary vascular bed of the rat. The American journal of physiology, 1994, Volume: 266, Issue:4 Pt 1 Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Blood Vessels; Captopril; Enalaprilat; Imidazoles; In Vitro Techniques; Losartan; Male; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Tetrazoles	1994
Oxytocic effect of trypsin on the isolated rat uterus. Hypertension (Dallas, Tex. : 1979), 1994, Volume: 23, Issue:1 Suppl Topics: Angiotensin I; Angiotensin II; Animals; Biphenyl Compounds; Bradykinin; Dose-Response Relationship, Drug; Enalaprilat; Female; Imidazoles; In Vitro Techniques; Isometric Contraction; Losartan; Oxytocin; Pepstatins; Rats; Saralasin; Tetrazoles; Trypsin; Uterine Contraction; Uterus	1994
Comparison of the effects of EXP3174, an angiotensin II antagonist and enalaprilat on myocardial infarct size in anaesthetized dogs. British journal of pharmacology, 1993, Volume: 110, Issue:3 Topics: Anesthesia; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Coronary Circulation; Disease Models, Animal; Dogs; Enalaprilat; Female; Furosemide; Heart Rate; Imidazoles; Injections, Intravenous; Losartan; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Renin-Angiotensin System; Tetrazoles	1993
Effect of selective angiotensin II receptor antagonism and angiotensin converting enzyme inhibition on the coronary vasculature in vivo. Intravascular two-dimensional and Doppler ultrasound studies. Circulation, 1993, Volume: 87, Issue:3 Topics: Adenosine; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Biphenyl Compounds; Blood Flow Velocity; Coronary Circulation; Coronary Vessels; Dogs; Enalaprilat; Female; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Rest; Tetrazoles; Ultrasonography; Vasodilation	1993
Angiotensin II conditions the slow component of autoregulation of renal blood flow. The American journal of physiology, 1993, Volume: 264, Issue:3 Pt 2 Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Enalaprilat; Homeostasis; Imidazoles; Kidney; Kinetics; Losartan; Male; Perfusion; Pressure; Rats; Rats, Sprague-Dawley; Tetrazoles; Vascular Resistance; Vasoconstriction; Vasodilation	1993
Endogenous angiotensin II modulates the effect of atrial natriuretic peptide on extracellular fluid partition. The American journal of physiology, 1993, Volume: 264, Issue:4 Pt 2 Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Biphenyl Compounds; Blood Pressure; Captopril; Enalaprilat; Extracellular Space; Hematocrit; Imidazoles; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin-Angiotensin System; Tetrazoles	1993
Role of angiotensin II in dietary modulation of rat late distal tubule bicarbonate flux in vivo. The Journal of clinical investigation, 1996, Jan-01, Volume: 97, Issue:1 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Bicarbonates; Biphenyl Compounds; Diet; Enalaprilat; Fasting; Imidazoles; Kidney Tubules, Distal; Losartan; Male; Perfusion; Rats; Rats, Sprague-Dawley; Renin; Sodium Chloride; Tetrazoles	1996
Effects of chronic treatment with losartan and enalaprilat on [3H]-norepinephrine release from isolated atria of Wistar-Kyoto and spontaneously hypertensive rats. American journal of hypertension, 1996, Volume: 9, Issue:1 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Body Weight; Bradykinin; Enalaprilat; Heart Atria; Imidazoles; Losartan; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin-Angiotensin System; Tetrazoles	1996
Regulation of angiotensin II receptor AT1 subtypes in renal afferent arterioles during chronic changes in sodium diet. The Journal of clinical investigation, 1997, Mar-01, Volume: 99, Issue:5 Topics: Actins; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Cloning, Molecular; Culture Techniques; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enalaprilat; Gene Expression Regulation; Imidazoles; Kidney; Losartan; Male; Oligopeptides; Polymerase Chain Reaction; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Renal Artery; Renal Circulation; Ribonucleases; RNA, Messenger; Sodium, Dietary; Tetrazoles; Vasoconstrictor Agents	1997
In vivo angiotensin II receptor blockade and converting enzyme inhibition on canine aortic viscoelasticity. The American journal of physiology, 1997, Volume: 272, Issue:2 Pt 2 Topics: Angiotensin I; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Dogs; Elasticity; Enalaprilat; Hypertension, Renovascular; Imidazoles; Losartan; Male; Reference Values; Tetrazoles; Viscosity	1997
Effects of renin-angiotensin blockade on sympathetic reactivity and beta-adrenergic pathway in the spontaneously hypertensive rat. Hypertension (Dallas, Tex. : 1979), 1997, Volume: 30, Issue:2 Pt 1 Topics: Adenylyl Cyclases; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Enalaprilat; Hypertension; Hypertrophy, Left Ventricular; Imidazoles; Losartan; Male; Myocardium; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, beta; Reflex; Renin-Angiotensin System; Sympathetic Nervous System; Tetrazoles	1997
Effect of luminal angiotensin II on rabbit proximal convoluted tubule bicarbonate absorption. The American journal of physiology, 1997, Volume: 273, Issue:4 Topics: Absorption; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Bicarbonates; Biological Transport; Enalaprilat; Female; Imidazoles; Kidney Tubules, Proximal; Losartan; Pyridines; Rabbits	1997
Contribution of angiotensin-converting enzyme to the cardiac metabolism of bradykinin: an interspecies study. The American journal of physiology, 1997, Volume: 273, Issue:5 Topics: Amino Acid Sequence; Angiotensin-Converting Enzyme Inhibitors; Animals; Antibodies; Bradykinin; Cross Reactions; Dogs; Enalaprilat; Humans; Kinetics; Losartan; Myocardium; Peptidyl-Dipeptidase A; Protease Inhibitors; Rabbits; Rats; Species Specificity; Substrate Specificity; Thiorphan	1997
Angiotensin II receptor antagonist EXP 3174 reduces infarct size comparable with enalaprilat and augments preconditioning in the pig heart. Cardiovascular drugs and therapy, 1997, Volume: 11, Issue:5 Topics: Angiotensin Receptor Antagonists; Animals; Enalaprilat; Hemodynamics; Imidazoles; Losartan; Male; Myocardial Infarction; Myocardium; Swine; Tetrazoles	1997
Sympathetic functions in NG-nitro-L-arginine-methyl-ester-induced hypertension: modulation by the renin-angiotensin system. Journal of hypertension, 1998, Volume: 16, Issue:1 Topics: Adenylyl Cyclases; Animals; Antihypertensive Agents; Enalaprilat; Enzyme Inhibitors; Epinephrine; GTP-Binding Proteins; Heart; Hemodynamics; Hypertension; In Vitro Techniques; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Organ Size; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Renin-Angiotensin System; Sympathetic Nervous System	1998
Role of central catecholaminergic pathways in the actions of endogenous ANG II on sympathetic reflexes. The American journal of physiology, 1998, Volume: 275, Issue:4 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Ascorbic Acid; Baroreflex; Blood Pressure; Brain; Enalaprilat; Female; Heart Rate; Hypoxia; Kidney; Losartan; Male; Oxidopamine; Rabbits; Reference Values; Renin-Angiotensin System; Sympathetic Nervous System	1998
Comparison of the effects of ACE inhibition with those of angiotensin II receptor antagonism on systolic and diastolic myocardial stunning in isolated rabbit heart. Molecular and cellular biochemistry, 1998, Volume: 186, Issue:1-2 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Diastole; Enalaprilat; In Vitro Techniques; Losartan; Myocardial Contraction; Myocardial Stunning; Rabbits; Systole	1998
Endogenous angiotensin II and bradykinin delay and attenuate the hypotension after N-type calcium channel blockade in conscious rabbits. Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:6 Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Bradykinin; Calcium Channel Blockers; Dose-Response Relationship, Drug; Enalaprilat; Heart Rate; Hypotension; Losartan; Nasopharynx; omega-Conotoxin GVIA; Peptides; Pressoreceptors; Propranolol; Rabbits; Renin-Angiotensin System	1998
Comparison between angiotensin receptor antagonism and converting enzyme inhibition in heart failure. Differential acute effects according to the renin-angiotensin system activation. Basic research in cardiology, 1999, Volume: 94, Issue:2 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Dogs; Enalaprilat; Female; Heart Failure; Hemodynamics; Imidazoles; Losartan; Male; Renin; Renin-Angiotensin System; Tetrazoles; Vasodilation	1999
Timed inhibition of the renin-angiotensin system suppresses the rise in blood pressure upon awakening in spontaneously hypertensive rats. American journal of hypertension, 1999, Volume: 12, Issue:11 Pt 1 Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Chronotherapy; Enalaprilat; Hypertension; Infusions, Intravenous; Losartan; Male; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System	1999
Interaction between norepinephrine release and intrarenal angiotensin II formation during renal nerve stimulation in dogs. Journal of cardiovascular pharmacology, 2000, Volume: 35, Issue:6 Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Dogs; Enalaprilat; Female; Kidney; Losartan; Male; Norepinephrine; Renal Circulation; Sympathetic Nervous System; Time Factors	2000
Effect of angiotensin inhibition on the coronary artery lower pressure limit in anesthetized dogs. Canadian journal of physiology and pharmacology, 2000, Volume: 78, Issue:11 Topics: Angiotensin Receptor Antagonists; Animals; Coronary Circulation; Coronary Vessels; Diastole; Dogs; Enalaprilat; Losartan; Male; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2	2000
Angiotensin converting enzyme (ACE) and non-ACE dependent angiotensin II generation in resistance arteries from patients with heart failure and coronary heart disease. Journal of the American College of Cardiology, 2001, Mar-15, Volume: 37, Issue:4 Topics: Acetylcholine; Aged; Angina Pectoris; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Arteries; Bradykinin; Chymases; Enalaprilat; Female; Heart Failure; Humans; In Vitro Techniques; Losartan; Male; Middle Aged; Oligopeptides; Peptidyl-Dipeptidase A; Serine Endopeptidases; Vascular Resistance; Vasoconstriction	2001
Cardiac nitric oxide production due to angiotensin-converting enzyme inhibition decreases beta-adrenergic myocardial contractility in patients with dilated cardiomyopathy. Journal of the American College of Cardiology, 2001, Volume: 38, Issue:2 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Cardiomyopathy, Dilated; Compliance; Depression, Chemical; Diastole; Dobutamine; Enalaprilat; Enzyme Inhibitors; Female; Heart; Hemodynamics; Humans; Losartan; Male; Middle Aged; Myocardial Contraction; Myocardium; Nitric Oxide; omega-N-Methylarginine; Ventricular Dysfunction, Left	2001
AT(1) and AT(2) receptor expression and blockade after acute ischemia-reperfusion in isolated working rat hearts. American journal of physiology. Heart and circulatory physiology, 2002, Volume: 282, Issue:4 Topics: Adenosine; Adrenergic alpha-Agonists; Anaerobiosis; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Arrhythmia Agents; Cyclic GMP; Enalaprilat; Gene Expression Regulation; Heart; Hemodynamics; In Vitro Techniques; Losartan; Mitogen-Activated Protein Kinases; Myocardial Reperfusion; Myocardial Reperfusion Injury; p38 Mitogen-Activated Protein Kinases; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Time Factors; Ventricular Function, Left	2002
Angiotensin-converting enzyme inhibitors improve coronary flow reserve in dilated cardiomyopathy by a bradykinin-mediated, nitric oxide-dependent mechanism. Circulation, 2002, Jun-11, Volume: 105, Issue:23 Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Cardiomyopathy, Dilated; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Enalaprilat; Enzyme Inhibitors; Hemodynamics; Kinetics; Losartan; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Receptor, Angiotensin, Type 1; Receptor, Bradykinin B2; Receptors, Bradykinin; Regional Blood Flow; Vasodilator Agents	2002
Enalaprilat, losartan and LU 135252 in coronary blood flow regulation. European journal of clinical investigation, 2003, Volume: 33, Issue:5 Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Bradykinin; Coronary Circulation; Enalaprilat; Female; Losartan; Male; Phenylpropionates; Pyrimidines; Swine	2003
Further studies on the effect of intracellular angiotensins on heart cell communication: on the role of endogenous angiotensin II. Regulatory peptides, 2003, Aug-15, Volume: 115, Issue:1 Topics: Angiotensin II; Animals; Cell Communication; Cricetinae; Dose-Response Relationship, Drug; Enalapril; Enalaprilat; Losartan; Male; Mesocricetus; Myocardium; Patch-Clamp Techniques; Peptides; Peptidyl-Dipeptidase A; Receptors, Angiotensin; Renin-Angiotensin System; Temperature; Time Factors	2003
Effect of angiotensin II type 2 receptor blockade on activation of mitogen-activated protein kinases after ischemia-reperfusion in isolated working rat hearts. Journal of cardiovascular pharmacology and therapeutics, 2003, Volume: 8, Issue:4 Topics: Angiotensin II Type 2 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Coronary Circulation; Cyclic GMP; Disease Models, Animal; Enalaprilat; Enzyme Activation; Heart; Losartan; Male; Mitogen-Activated Protein Kinases; Models, Cardiovascular; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger	2003
Losartan but not enalaprilat acutely reduces reperfusion ventricular tachyarrhythmias in hypertrophied rat hearts after low-flow ischaemia. The Journal of pharmacy and pharmacology, 2004, Volume: 56, Issue:4 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Enalaprilat; Heart; Hypertrophy, Left Ventricular; In Vitro Techniques; Losartan; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tachycardia, Ventricular; Ventricular Fibrillation	2004
Intracellular and extracellular angiotensin II enhance the L-type calcium current in the failing heart. Hypertension (Dallas, Tex. : 1979), 2004, Volume: 44, Issue:3 Topics: Adenosine Triphosphatases; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Animals; Calcium Channels, L-Type; Calcium Signaling; Cardiomyopathies; Cells, Cultured; Cricetinae; Enalaprilat; Enzyme Activation; Extracellular Fluid; Intracellular Fluid; Losartan; Male; Mesocricetus; Myocytes, Cardiac; Protein Kinase C; Sarcoplasmic Reticulum; Staurosporine; Thapsigargin	2004
Oxidant stress in kidneys of spontaneously hypertensive rats involves both oxidase overexpression and loss of extracellular superoxide dismutase. American journal of physiology. Renal physiology, 2004, Volume: 287, Issue:5 Topics: Acetophenones; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Bradykinin; Enalaprilat; Free Radical Scavengers; Immunoblotting; In Vitro Techniques; Kidney; Kidney Cortex; Losartan; NADPH Oxidases; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxidative Stress; Oxygen Consumption; Rats; Rats, Inbred SHR; Rats, Inbred WKY; S-Nitroso-N-Acetylpenicillamine; Superoxide Dismutase	2004
Ouabain at nanomolar concentration promotes synthesis and release of angiotensin II from the endothelium of the tail vascular bed of spontaneously hypertensive rats. Journal of cardiovascular pharmacology, 2004, Volume: 44, Issue:3 Topics: Angiotensin II; Animals; Blood Pressure; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Enalaprilat; Endothelium, Vascular; Glucose; Hexamethonium; Injections, Intravenous; Losartan; Male; Muscle, Smooth, Vascular; Ouabain; Perfusion; Phenylephrine; Potassium Chloride; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium-Potassium-Exchanging ATPase; Tail; Time Factors; Tromethamine; Vasodilation	2004
Glomerular abundance of nephrin and podocin in experimental nephrotic syndrome: different effects of antiproteinuric therapies. American journal of physiology. Renal physiology, 2005, Volume: 289, Issue:4 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Doxorubicin; Enalaprilat; Enzyme Inhibitors; Fluorescent Antibody Technique; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Kidney Glomerulus; Losartan; Male; Membrane Proteins; Mycophenolic Acid; Nephrotic Syndrome; Protein Synthesis Inhibitors; Proteinuria; Pyridines; Rats; Rats, Sprague-Dawley; Thiazepines	2005
Impairment of endothelium-dependent relaxation of rat aortas by homocysteine thiolactone and attenuation by captopril. Journal of cardiovascular pharmacology, 2007, Volume: 50, Issue:2 Topics: Acetylcholine; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Captopril; Dose-Response Relationship, Drug; Enalaprilat; Endothelium, Vascular; Free Radicals; Homocysteine; Losartan; Malondialdehyde; Nitric Oxide; Nitroprusside; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Vasodilation	2007
Gadolinium increases the vascular reactivity of rat aortic rings. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2011, Volume: 44, Issue:5 Topics: Animals; Antihypertensive Agents; Aorta; Dose-Response Relationship, Drug; Enalaprilat; Endothelium, Vascular; Female; Gadolinium; Losartan; Male; NG-Nitroarginine Methyl Ester; Phenylephrine; Rats; Rats, Wistar; Vasoconstriction; Vasodilation	2011
Myocardial autophagy after severe burn in rats. PloS one, 2012, Volume: 7, Issue:6 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Biomarkers; Biphenyl Compounds; Burns; Enalaprilat; Fluorescent Antibody Technique; Heart Function Tests; In Vitro Techniques; Losartan; Male; Microtubule-Associated Proteins; Myocardium; Onium Compounds; Rats; Rats, Sprague-Dawley	2012
Chronic infusion of enalaprilat into hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension and cardiac hypertrophy by restoring neurotransmitters and cytokines. Toxicology and applied pharmacology, 2014, Feb-01, Volume: 274, Issue:3 Topics: Angiotensin II; Animals; Cardiomegaly; Chemokine CCL2; Enalaprilat; gamma-Aminobutyric Acid; Glutamic Acid; Heart; Hypertension; Interleukin-10; Interleukin-1beta; Interleukin-6; Kidney; Losartan; Male; Neurotransmitter Agents; Norepinephrine; Organ Size; Paraventricular Hypothalamic Nucleus; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System	2014
Blockade of the renin-angiotensin system prevents acute and immunologically relevant colitis in murine models. Pediatric surgery international, 2016, Volume: 32, Issue:12 Topics: Acute Disease; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Colitis; Cyclooxygenase Inhibitors; Disease Models, Animal; Enalaprilat; Losartan; Mice; Mice, Inbred C57BL; Piroxicam; Renin-Angiotensin System	2016
Enalaprilat and losartan decrease erythroid precursors frequency in cells from patients with polycythemia vera. Hematology (Amsterdam, Netherlands), 2023, Volume: 28, Issue:1 Topics: Enalaprilat; Erythrocytes; Humans; Losartan; Polycythemia; Polycythemia Vera	2023