losartan has been researched along with candesartan cilexetil in 59 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 33 (55.93) | 18.2507 |
| 2000's | 18 (30.51) | 29.6817 |
| 2010's | 5 (8.47) | 24.3611 |
| 2020's | 3 (5.08) | 2.80 |
| Authors | Studies |
|---|---|
| Furukawa, Y; Inada, Y; Kato, T; Kohara, Y; Kubo, K; Naka, T; Nishikawa, K; Shibouta, Y; Yoshimura, Y | 1 |
| Goldberg, MR; Greenlee, WJ; Irvin, JD; Prendergast, K; Smith, RD; Timmermans, PB; Wexler, RR | 1 |
| Funakoshi, J; Kakumoto, M; Okumura, K; Sakaeda, T; Takara, K; Tanigawara, Y | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Giridhar, R; Murumkar, P; Naik, P; Yadav, MR | 1 |
| Gust, R; Obexer, P; Salcher, S; Schoepf, AM | 1 |
| Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF | 1 |
| Bauer, JH; Reams, GP | 1 |
| Brunner, HR; Burnier, M; Delacrétaz, E; Nussberger, J; Waeber, B | 1 |
| Jover, B; Mimran, A | 1 |
| Ebihara, A; Fujimura, A; Sudoh, T | 1 |
| Inada, Y; Itoh, K; Kohara, Y; Kubo, K; Naka, T; Ohtsuki, K; Ojima, M; Sanada, T; Shibouta, Y; Wada, T | 1 |
| Tanaka, H | 1 |
| Nishikawa, K | 2 |
| Inada, Y; Kohara, Y; Kubo, K; Naka, T; Nishikawa, K; Noda, M; Ojima, M; Sanada, T; Shibouta, Y; Wada, T | 1 |
| Biollaz, J; Brunner, HR; Buclin, T; Burnier, M; Nussberger, J; Waeber, B | 1 |
| Chikugo, F; Fukuta, Y; Hori, T; Houchi, H; Katoh, I; Kawahito, T; Kitagawa, T; Oka, M; Yoshizumi, M | 1 |
| Biollaz, J; Brunner, HR; Buclin, T; Csajka, C | 1 |
| Arendshorst, WJ; Best, CF; Coffman, TM; Kim, HS; Oliverio, MI; Smithies, O | 1 |
| Kim, S | 2 |
| Ogihara, T; Rakugi, H | 2 |
| Belz, GG; Fuchs, B; Magin, SG; Malerczyk, C; Mutschler, E; Roll, S | 1 |
| Andersson, OK; Neldam, S | 2 |
| Goligorsky, MS; Kornfeld, M; Moore, LC; Thorup, C; Winaver, JM | 1 |
| Bunt, T; Dumaswala, A | 1 |
| Anderson, OK; Neldam, S | 1 |
| Andersson, OK | 1 |
| Kurtz, A; Wagner, C | 1 |
| Morsing, P | 1 |
| Sever, PS | 1 |
| Chung, O; Csikós, T; Unger, T | 1 |
| Azizi, M; Chatellier, G; Guyene, TT; Ménard, J | 1 |
| Ardaillou, R; Chansel, D; Henrion, D; Levy, BI; Loufrani, L | 1 |
| Riegger, GA | 1 |
| Dell'Oro, R; Grassi, G; Mancia, G; Turri, C | 1 |
| Asmar, R; Lacourcière, Y | 2 |
| Oparil, S | 1 |
| Casley, DJ; Dinh, DT; Fabiani, ME; Johnston, CI; Nassis, L | 1 |
| Kromer, EP | 1 |
| Badguet, JP; Mallion, JM | 1 |
| Burnier, M | 1 |
| Harris, S; Michelson, EL; Rahman, M; Ridley, E; Vendetti, J; Vidt, DG; Wang, R; White, WB | 1 |
| Belz, GG; Breithaupt-Grögler, K; Butzer, R; Fuchs, W; Hausdorf, C; Mang, C | 1 |
| Boer, P; Gaillard, CA; Rabelink, TJ; Willemsen, JM | 1 |
| Asmar, R; Baguet, JP; Mallion, JM; Mouret, S; Nisse-Durgeat, S | 1 |
| Bianchetti, MG; Fossali, E; Konrad, M; Rizzi, M; Simonetti, GD; von Vigier, RO | 1 |
| Koyabu, N; Kuwano, M; Murakami, H; Nakamura, T; Ohtani, H; Satoh, H; Sawada, Y; Tsujimoto, M; Uchiumi, T; Ushigome, F; Yamashita, F | 1 |
| Bianchetti, MG; Fossali, E; Ghiglia, S; Limoni, C; Meier, CM; Salice, P; Simonetti, GD | 1 |
| Mitsuyama, S | 1 |
| Kim-Mitsuyama, S | 1 |
| Kamiyama, E; Mikkaichi, T; Nakai, D; Okazaki, O; Okudaira, N | 1 |
| Benndorf, RA; Böger, RH; Divac, N; Haefeli, WE; Herzog, M; Sauer, A; Schwedhelm, E; Weiss, J | 1 |
| Asai, S; Kanou, N; Nakayama, T; Nishida, Y; Susa, N; Takahashi, Y | 1 |
| Abdelsalam, RA; Haddad, GM; Marghany, KA | 1 |
25 review(s) available for losartan and candesartan cilexetil
| Article | Year |
|---|---|
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Humans; Receptors, Angiotensin; Structure-Activity Relationship | 1996 |
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Antihypertensive Agents; Humans; Losartan | 2010 |
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Neoplasm Proteins; Neoplastic Stem Cells | 2022 |
The angiotensin II type 1 receptor antagonists. A new class of antihypertensive drugs.
Topics: Acrylates; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Humans; Imidazoles; Irbesartan; Losartan; Pyridines; Quinolines; Telmisartan; Tetrazoles; Thiophenes; Valine; Valsartan | 1995 |
Angiotensin II antagonists DuP 753 and TCV 116.
Topics: Administration, Oral; Angiotensin II; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Humans; Hypertension; Imidazoles; Losartan; Renin-Angiotensin System; Tetrazoles | 1994 |
Angiotensin II receptor antagonists versus angiotensin converting enzyme inhibitors: effects on renal function.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Kidney; Losartan; Receptors, Angiotensin; Renin-Angiotensin System; Tetrazoles | 1994 |
[Receptor agonists and antagonists: the present and future].
Topics: Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Benzodiazepinones; Biphenyl Compounds; Cholinergic Antagonists; Devazepide; Erythromycin; Imidazoles; Ligands; Losartan; Peptides; Receptors, Cholecystokinin; Receptors, Gastrointestinal Hormone; Receptors, Neuropeptide; Tetrazoles | 1993 |
[Nonpeptide angiotensin II receptor antagonists].
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cricetinae; Imidazoles; In Vitro Techniques; Losartan; Receptors, Angiotensin; Tetrazoles | 1993 |
Pharmacokinetic-pharmacodynamic relationships of three angiotensin II receptor antagonists in normal volunteers.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Humans; Imidazoles; Irbesartan; Losartan; Prodrugs; Reference Values; Tetrazoles | 1996 |
Pharmacokinetic-pharmacodynamic profile of angiotensin II receptor antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Clinical Trials as Topic; Humans; Imidazoles; Losartan; Renin; Tetrazoles; Valine; Valsartan | 1997 |
[Role of the renin-angiotensin system in cardiovascular and renal diseases].
Topics: Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Cardiovascular Diseases; Fibronectins; Gene Expression; Humans; Imidazoles; Kidney Diseases; Losartan; Proto-Oncogenes; Rats; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Renin-Angiotensin System; Tetrazoles; Transforming Growth Factor beta | 1997 |
[Angiotensin receptor antagonist for therapy of patients with hypertension].
Topics: Aged; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Double-Blind Method; Heart Failure; Humans; Hypertension; Losartan; Prodrugs; Randomized Controlled Trials as Topic; Renin-Angiotensin System; Tetrazoles | 1997 |
Angiotensin AT1 receptor antagonism and protection against cardiovascular end-organ damage.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cardiovascular Diseases; Cerebrovascular Disorders; Disease Models, Animal; Hypertension; Losartan; Male; Nephrectomy; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles | 1998 |
Tolerability of a modern antihypertensive agent: candesartan cilexetil.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Humans; Losartan; Prodrugs; Randomized Controlled Trials as Topic; Tetrazoles | 1998 |
Candesartan: a new-generation angiotensin II AT1 receptor blocker: pharmacology, antihypertensive efficacy, renal function, and renoprotection.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Hemodynamics; Humans; Hypertension; Irbesartan; Kidney; Losartan; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles | 1999 |
Angiotensin II receptor pharmacology and AT1-receptor blockers.
Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles; Thiophenes | 1999 |
[ACE inhibitors or AT1 receptor antagonists?].
Topics: Age Factors; Aged; Angiotensin I; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Captopril; Clinical Trials as Topic; Death, Sudden, Cardiac; Enalapril; Heart Failure; Humans; Losartan; Prodrugs; Prognosis; Randomized Controlled Trials as Topic; Risk Factors; Tetrazoles; Time Factors | 1999 |
Newly emerging pharmacologic differences in angiotensin II receptor blockers.
Topics: Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Humans; Hypertension; Losartan; Prodrugs; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles | 2000 |
[Angiotensin-II-receptor antagonists for cardiac insufficiency].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Captopril; Dose-Response Relationship, Drug; Drug Therapy, Combination; Heart Failure; Humans; Losartan; Randomized Controlled Trials as Topic; Tetrazoles | 2000 |
Putting the efficacy of candesartan cilexetil into perspective: a review of new comparative data.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cattle; Cerebellum; Circadian Rhythm; Female; Heart; Humans; Hypertension; In Vitro Techniques; Irbesartan; Kinetics; Losartan; Male; Middle Aged; Prodrugs; Rabbits; Randomized Controlled Trials as Topic; Receptors, Angiotensin; Renin; Tetrazoles; Time Factors | 2000 |
Angiotensin II type 1 receptor blockers.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Binding, Competitive; Biphenyl Compounds; Blood Pressure; Drug Design; Humans; Irbesartan; Losartan; Peptidyl-Dipeptidase A; Protein Binding; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin-Angiotensin System; Saralasin; Tetrazoles; Valine; Valsartan | 2001 |
[Review of randomized trials of angiotensin receptor blockers in the treatment of patients with congestive heart failure].
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Captopril; Drug Therapy, Combination; Heart Failure; Humans; Losartan; Randomized Controlled Trials as Topic; Tetrazoles; Valine; Valsartan | 2001 |
[Tendency and prospect of the development of new ARBs].
Topics: Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Cardiovascular Diseases; Humans; Losartan; Receptor, Angiotensin, Type 1; Tetrazoles; Valine; Valsartan | 2002 |
[ARB: characteristics, mechanisms of action, pharmacokinetics, indication, contraindication, clinical data, and side effects].
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Biphenyl Compounds; Clinical Trials as Topic; Contraindications; Heart Failure; Humans; Hypertension; Imidazoles; Losartan; Telmisartan; Tetrazoles; Valine; Valsartan | 2007 |
[Pharmacological characteristics of ARB and potential strategy to develop novel ARB].
Topics: Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Losartan; Tetrazoles | 2009 |
12 trial(s) available for losartan and candesartan cilexetil
| Article | Year |
|---|---|
A comparison of the antihypertensive effects of candesartan cilexetil and losartan in patients with mild to moderate hypertension.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Double-Blind Method; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Tetrazoles | 1997 |
The antihypertensive effect and tolerability of candesartan cilexetil, a new generation angiotensin II antagonist, in comparison with losartan.
Topics: Adult; Angiotensin II; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Losartan; Male; Middle Aged; Tetrazoles; Treatment Outcome | 1998 |
Pharmacokinetic-pharmacodynamic interactions of candesartan cilexetil and losartan.
Topics: Administration, Oral; Adolescent; Adult; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Double-Blind Method; Humans; Losartan; Male; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin; Tetrazoles | 1999 |
Comparison of angiotensin II receptor blockers: impact of missed doses of candesartan cilexetil and losartan in systemic hypertension.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Data Interpretation, Statistical; Drug Administration Schedule; Humans; Hypertension; Hypertrophy, Left Ventricular; Losartan; Middle Aged; Patient Compliance; Randomized Controlled Trials as Topic; Tetrazoles; Treatment Outcome | 1999 |
A comparison of the efficacy and duration of action of candesartan cilexetil and losartan as assessed by clinic and ambulatory blood pressure after a missed dose, in truly hypertensive patients: a placebo-controlled, forced titration study. Candesartan/Lo
Topics: Adult; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Outpatients; Safety; Tetrazoles; Treatment Outcome | 1999 |
A new approach to assessing antihypertensive therapy: effect of treatment on pulse pressure. Candesartan cilexetil in Hypertension Ambulatory Measurement of Blood Pressure (CHAMP) Study Investigators.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Double-Blind Method; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Tetrazoles | 2000 |
A forced titration study of antihypertensive efficacy of candesartan cilexetil in comparison to losartan: CLAIM Study II.
Topics: Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Female; Humans; Hypertension; Losartan; Male; Prodrugs; Tetrazoles; Treatment Outcome | 2001 |
The pharmacological potency of various AT(1) antagonists assessed by Schild regression technique in man.
Topics: Adult; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Irbesartan; Losartan; Male; Receptor, Angiotensin, Type 1; Reference Values; Tetrazoles; Valine; Valsartan | 2000 |
Disparate systemic and renal blocking properties of angiotensin II antagonists during exogenous angiotensin II administration: implications for treatment.
Topics: Adult; Aged; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biphenyl Compounds; Child; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Hemodynamics; Humans; Hypertension; Kidney; Losartan; Middle Aged; Renal Circulation; Renin; Tetrazoles | 2004 |
A placebo-controlled comparison of the efficacy and tolerability of candesartan cilexetil, 8 mg, and losartan, 50 mg, as monotherapy in patients with essential hypertension, using 36-h ambulatory blood pressure monitoring.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Losartan; Male; Middle Aged; Tetrazoles; Treatment Outcome | 2006 |
Candesartan cilexetil in children with hypertension or proteinuria: preliminary data.
Topics: Adolescent; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biphenyl Compounds; Child; Child, Preschool; Female; Humans; Hypertension; Infant; Irbesartan; Losartan; Male; Proteinuria; Tablets; Tetrazoles | 2006 |
Palatability of angiotensin II antagonists among nephropathic children.
Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Child; Child, Preschool; Female; Humans; Irbesartan; Kidney Diseases; Losartan; Male; Patient Compliance; Patient Satisfaction; Smell; Taste; Telmisartan; Tetrazoles; Valine; Valsartan | 2007 |
22 other study(ies) available for losartan and candesartan cilexetil
| Article | Year |
|---|---|
Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids.
Topics: Administration, Oral; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biological Availability; Biphenyl Compounds; Male; Prodrugs; Rats; Rats, Sprague-Dawley; Tetrazoles | 1993 |
Interaction of digoxin with antihypertensive drugs via MDR1.
Topics: Animals; Antihypertensive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Digoxin; Drug Interactions; Humans; Time Factors | 2002 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Identification and development of non-cytotoxic cell death modulators: Impact of sartans and derivatives on PPARγ activation and on growth of imatinib-resistant chronic myelogenous leukemia cells.
Topics: Animals; Cell Death; Cell Proliferation; Chlorocebus aethiops; COS Cells; Drug Design; Drug Resistance, Neoplasm; Humans; Imatinib Mesylate; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; PPAR gamma; Structure-Activity Relationship; Telmisartan | 2020 |
Effect of angiotensin II type 1 receptor antagonist on urinary prostaglandin E2 excretion following furosemide in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Dinoprostone; Furosemide; Imidazoles; Indans; Losartan; Male; Prodrugs; Rats; Rats, Wistar; Tetrazoles | 1994 |
Antihypertensive effects of a highly potent and long-acting angiotensin II subtype-1 receptor antagonist, (+-)-1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H- benzimidazole-7-carboxylate (TCV-116), in various
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Imidazoles; Losartan; Male; Molecular Structure; Rats; Rats, Inbred SHR; Rats, Wistar; Species Specificity; Tetrazoles; Vasoconstriction | 1994 |
Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethy
Topics: Adrenal Cortex; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cattle; Imidazoles; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Prodrugs; Protein Binding; Rabbits; Rats; Rats, Sprague-Dawley; Substrate Specificity; Tetrazoles | 1993 |
Angiotensin II as a stimulator of Na(+)-dependent Ca2+ efflux from freshly isolated adult rat cardiomyocytes.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Calcium; Calcium Radioisotopes; Dose-Response Relationship, Drug; Imidazoles; Losartan; Male; Muscle Fibers, Skeletal; Myocardium; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium; Tetrazoles | 1996 |
Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Enalapril; Hexamethonium; Imidazoles; Kidney; Losartan; Mice; Mice, Knockout; Phentolamine; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Renin; RNA, Messenger; Sympatholytics; Tetrazoles; Time Factors; Transcription, Genetic | 1997 |
Inhibition of angiotensin II pressor response and ex vivo angiotensin II radioligand binding by candesartan cilexetil and losartan in healthy human volunteers.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Double-Blind Method; Humans; Losartan; Male; Tetrazoles | 1997 |
Angiotensin-II stimulates nitric oxide release in isolated perfused renal resistance arteries.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Electric Conductivity; Endothelium, Vascular; Losartan; Male; Microelectrodes; Nitric Oxide; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renal Artery; Tetrazoles; Vascular Resistance | 1998 |
Candesartan vs losartan.
Topics: Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Confounding Factors, Epidemiologic; Humans; Hypertension; Losartan; Research Design; Tetrazoles | 1998 |
Candesartan cilexetil vs losartan.
Topics: Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Humans; Hypertension; Losartan; Randomized Controlled Trials as Topic; Research Design; Tetrazoles; Therapeutic Equivalency | 1998 |
Effects of candesartan on the renin system in conscious rats.
Topics: Adrenal Glands; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Losartan; Male; Ramipril; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin; Renin-Angiotensin System; RNA, Messenger; Tetrazoles | 1999 |
Key features of candesartan cilexetil and a comparison with other angiotensin II receptor antagonists.
Topics: Amlodipine; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Delayed-Action Preparations; Diuretics; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Losartan; Renin-Angiotensin System; Retrospective Studies; Sodium Chloride Symporter Inhibitors; Tetrazoles; Treatment Outcome | 1999 |
Functional evidence for an angiotensin IV receptor in rat resistance arteries.
Topics: Animals; Benzimidazoles; Biphenyl Compounds; Drug Interactions; Imidazoles; In Vitro Techniques; Indomethacin; Losartan; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Perfusion; Phenylephrine; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Serotonin; Tachyphylaxis; Tetrazoles; Vascular Resistance | 1999 |
In vivo inhibition of angiotensin receptors in the rat kidney by candesartan cilexetil: a comparison with losartan.
Topics: Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Imidazoles; Kidney; Losartan; Male; Membranes; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin; Tetrazoles | 2000 |
Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4.
Topics: Acetates; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biological Transport; Biphenyl Compounds; Blotting, Western; Cell Line; Chromones; Cyclopropanes; Dose-Response Relationship, Drug; Estrone; Humans; Imidazoles; Indoles; Leukotriene Antagonists; Losartan; Molecular Structure; Organic Anion Transporters, Sodium-Independent; Phenylcarbamates; Quinolines; Structure-Activity Relationship; Sulfides; Sulfonamides; Tetrazoles; Tosyl Compounds; Transfection; Tritium; Valine; Valsartan | 2006 |
Interaction of angiotensin II type 1 receptor blockers with P-gp substrates in Caco-2 cells and hMDR1-expressing membranes.
Topics: Adenosine Triphosphatases; Angiotensin II Type 1 Receptor Blockers; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Benzoates; Biological Transport; Biphenyl Compounds; Caco-2 Cells; Calcium Channel Blockers; Cardiotonic Agents; Cell Membrane; Digoxin; Drug Interactions; Humans; Irbesartan; Losartan; Telmisartan; Tetrazoles; Verapamil | 2010 |
Interaction of angiotensin receptor type 1 blockers with ATP-binding cassette transporters.
Topics: Acrylates; Angiotensin II Type 1 Receptor Blockers; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Benzimidazoles; Biological Transport; Biphenyl Compounds; Digoxin; Fluoresceins; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Membrane Transport Proteins; Mice; Multidrug Resistance-Associated Protein 2; Olmesartan Medoxomil; Tetrazoles; Thiophenes | 2010 |
Comparative effect of angiotensin II type I receptor blockers on serum uric acid in hypertensive patients with type 2 diabetes mellitus: a retrospective observational study.
Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Biphenyl Compounds; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Imidazoles; Logistic Models; Losartan; Male; Middle Aged; Multivariate Analysis; Olmesartan Medoxomil; Retrospective Studies; Telmisartan; Tetrazoles; Treatment Outcome; Uric Acid; Valine; Valsartan | 2013 |
HPLC method transfer study for simultaneous determination of seven angiotensin II receptor blockers.
Topics: Acrylates; Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Chlorthalidone; Chromatography, High Pressure Liquid; Hydrochlorothiazide; Imidazoles; Irbesartan; Losartan; Molecular Structure; Software; Tablets; Tetrazoles; Thiophenes; Valsartan | 2020 |