losartan and bosentan anhydrous

losartan has been researched along with bosentan anhydrous in 28 studies

Research

Studies (28)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (25.00)	18.2507
2000's	11 (39.29)	29.6817
2010's	10 (35.71)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Bai, R; Jiang, J; Liu, J; Wang, Q; Wei, Z; Wu, X; Xie, W; Xu, J; Yao, H	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Leskinen, H; Ruskoaho, H; Vuolteenaho, O	1
Magga, J; Marttila, M; Ruskoaho, H; Vuolteenaho, O	1
Charlier, AA; Donckier, JE; Heyndrickx, GR; Hodeige, DG; Ketelslegers, JM; Massart, PE; Van Mechelen, H	1
Demeilliers, B; Herizi, A; Jover, B; Mimran, A	1
Baylis, C; Qiu, C	1
Borthayre, AB; Harrison, DG; Hink, U; Kurz, S; Münzel, T; Nickenig, G	1
Bellissant, E; Durand-Castel, X; Goineau, S; Guillo, P; Pape, D	1
Beresewicz, A; Maczewski, M	1
Belabbas, H; Herizi, A; Jover, B; Mimran, A	1
Juncos, LA; Manriquez, MC; Ortiz, MC; Romero, JC; Sanabria, E	1
Gosek, K; Grzeszczak, W; Zukowska-Szczechowska, E	1
Chen, Y; Tang, T; Wang, X; Zhang, J	1
Capuano, V; Coulombe, A; Deroubaix, E; Ferron, L; Renaud, JF; Ruchon, Y	1
Elena, JV; Grujić-Adanja, G; Jerkić, M; Jovović, D; López-Novoa, JM; Manero, MV; Marković-Lipkovski, J; Mihailović-Stanojević, N; Miloradović, Z; Nastić-Mirić, D; Prieto, MP; Rodríguez-Barbero, A; Vojvodić, SB	1
Charles, CJ; Espiner, EA; Frampton, CM; Nicholls, MG; Rademaker, MT; Richards, AM	1
Jerkić, M; Jovović, D; Marković-Lipkovski, J; Mihailović-Stanojević, N; Milanović, JG; Miloradović, Z; Stosić, G	1
Banoglu, ZN; Dengiz, GO; Kandemir, NO; Kurcer, Z; Mungan, G; Ozacmak, VH; Turkili, B	1
Bahde, R; Bandi, S; Bhargava, KK; Gupta, S; Kapoor, S; Palestro, CJ	1
De Mey, JG; Janssen, B; Lemkens, P; Meens, MJ; Nelissen, J; Peters, SL; Schiffers, PM; Spijkers, LJ	1

Reviews

2 review(s) available for losartan and bosentan anhydrous

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Antihypertensive treatment in patients with diabetes mellitus]. Polskie Archiwum Medycyny Wewnetrznej, 2002, Volume: 108, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Bosentan; Diabetes Complications; Endothelins; Heart Failure; Humans; Hypertension; Kidney Failure, Chronic; Losartan; Sulfonamides; Time Factors	2002

Trials

1 trial(s) available for losartan and bosentan anhydrous

Article	Year
Combined inhibition of angiotensin II and endothelin suppresses the brain natriuretic peptide response to developing heart failure. Clinical science (London, England : 1979), 2004, Volume: 106, Issue:6 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Bosentan; Cardiac Output; Cardiac Output, Low; Cardiac Pacing, Artificial; Cyclic GMP; Endothelin Receptor Antagonists; Endothelin-1; Female; Infusions, Parenteral; Losartan; Natriuretic Peptide, Brain; Renin; Sheep; Sulfonamides	2004

Article

Year

Combined inhibition of angiotensin II and endothelin suppresses the brain natriuretic peptide response to developing heart failure.

Clinical science (London, England : 1979), 2004, Volume: 106, Issue:6

Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Bosentan; Cardiac Output; Cardiac Output, Low; Cardiac Pacing, Artificial; Cyclic GMP; Endothelin Receptor Antagonists; Endothelin-1; Female; Infusions, Parenteral; Losartan; Natriuretic Peptide, Brain; Renin; Sheep; Sulfonamides

2004

Other Studies

25 other study(ies) available for losartan and bosentan anhydrous

Article	Year
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Synthesis and biological evaluation of 4'-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists. Bioorganic & medicinal chemistry, 2012, Aug-01, Volume: 20, Issue:15 Topics: Angiotensin Receptor Antagonists; Animals; Benzimidazoles; CHO Cells; Cricetinae; Endothelin A Receptor Antagonists; Humans; Male; Molecular Structure; Rats; Rats, Inbred SHR; Receptors, Angiotensin; Structure-Activity Relationship; Sulfonamides	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump. Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:3 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index	2014
Combined inhibition of endothelin and angiotensin II receptors blocks volume load-induced cardiac hormone release. Circulation research, 1997, Volume: 80, Issue:1 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atrial Function, Right; Atrial Natriuretic Factor; Biphenyl Compounds; Blood Volume; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hemodynamics; Hormones; Imidazoles; Losartan; Male; Myocardium; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Peptides, Cyclic; Plasma Substitutes; Pressure; Protein Precursors; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetrazoles	1997
Endothelin-1 is involved in stretch-induced early activation of B-type natriuretic peptide gene expression in atrial but not in ventricular myocytes: acute effects of mixed ET(A)/ET(B) and AT1 receptor antagonists in vivo and in vitro. Circulation, 1997, Nov-04, Volume: 96, Issue:9 Topics: Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Gene Expression Regulation; Losartan; Male; Myocardium; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Perfusion; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; RNA, Messenger; Sulfonamides; Tetrazoles	1997
Angiotensin II and endothelin-1 receptor antagonists have cumulative hypotensive effects in canine Page hypertension. Journal of hypertension, 1998, Volume: 16, Issue:6 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Bosentan; Disease Models, Animal; Dogs; Endothelin Receptor Antagonists; Endothelin-1; Hypertension, Renovascular; Infusions, Intravenous; Losartan; Radioimmunoassay; Receptor, Endothelin A; Sulfonamides; Vascular Resistance	1998
[Renal alterations in L-NAME hypertension: influence of losartan and bosentan]. Archives des maladies du coeur et des vaisseaux, 1998, Volume: 91, Issue:8 Topics: Albuminuria; Animals; Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Enzyme Inhibitors; Hemodynamics; Hypertension; Kidney; Kidney Function Tests; Losartan; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Sulfonamides	1998
Endothelin and angiotensin mediate most glomerular responses to nitric oxide inhibition. Kidney international, 1999, Volume: 55, Issue:6 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Kidney Glomerulus; Losartan; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Renal Circulation; Sulfonamides	1999
Evidence for a causal role of the renin-angiotensin system in nitrate tolerance. Circulation, 1999, Jun-22, Volume: 99, Issue:24 Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Bosentan; Dose-Response Relationship, Drug; Drug Tolerance; Endothelium, Vascular; Female; Gene Expression; Losartan; Luminescent Measurements; Male; Multienzyme Complexes; NADH, NADPH Oxidoreductases; NADPH Oxidases; Nitrates; Nitric Oxide; Nitroglycerin; Peptidyl-Dipeptidase A; Rabbits; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin; Renin-Angiotensin System; RNA, Messenger; Sulfonamides; Superoxides; Vasoconstriction; Vasodilation; Vasodilator Agents	1999
Endothelin, but not angiotensin II, contributes to the hypoxic contractile response of large isolated pulmonary arteries in the rat. Fundamental & clinical pharmacology, 1999, Volume: 13, Issue:4 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Azepines; Bosentan; Calcium; Calcium Channel Blockers; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Extracellular Space; Glycopeptides; Hypoxia; In Vitro Techniques; Indoles; Lisinopril; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Pulmonary Artery; Rats; Rats, Wistar; Sulfonamides	1999
The role of endothelin, protein kinase C and free radicals in the mechanism of the post-ischemic endothelial dysfunction in guinea-pig hearts. Journal of molecular and cellular cardiology, 2000, Volume: 32, Issue:2 Topics: Acetylcholine; Adrenergic alpha-Antagonists; Alkaloids; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Arrhythmia Agents; Aspartic Acid Endopeptidases; Benzophenanthridines; Bosentan; Captopril; Catalase; Coronary Vessels; Endothelin-Converting Enzymes; Endothelins; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Female; Free Radicals; Glycopeptides; Guinea Pigs; Heart; Losartan; Male; Metalloendopeptidases; Muscle Proteins; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Nitroprusside; Oxidative Stress; Phenanthridines; Prazosin; Protein Kinase C; Reactive Oxygen Species; Sulfonamides; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Vasodilator Agents	2000
[Cardiac and vascular hypertrophy in hypertension due to angiotensin II. Effect of losartan and bosentan]. Archives des maladies du coeur et des vaisseaux, 2000, Volume: 93, Issue:8 Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Bosentan; Cardiomegaly; Carotid Arteries; Endothelin Receptor Antagonists; Endothelins; Follow-Up Studies; Hypertension; Hypertrophy; Losartan; Male; Organ Size; Rats; Rats, Sprague-Dawley; Sulfonamides	2000
Role of endothelin and isoprostanes in slow pressor responses to angiotensin II. Hypertension (Dallas, Tex. : 1979), 2001, Volume: 37, Issue:2 Pt 2 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Bosentan; Endothelins; Glomerular Filtration Rate; Infusions, Intravenous; Losartan; Nitrites; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Sulfonamides	2001
Effect of angiotensin II receptor antagonist and endothelin receptor antagonist on nitroglycerin tolerance in rats. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 2001, Volume: 16, Issue:2 Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Bosentan; Drug Tolerance; Endothelin Receptor Antagonists; Losartan; Male; Nitroglycerin; Rats; Rats, Wistar; Sulfonamides; Vasodilator Agents	2001
Angiotensin II signaling pathways mediate expression of cardiac T-type calcium channels. Circulation research, 2003, Dec-12, Volume: 93, Issue:12 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Bosentan; Butadienes; Calcium Channels, T-Type; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Constriction, Pathologic; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Flavonoids; Gene Expression; Losartan; Male; Membrane Potentials; Mitogen-Activated Protein Kinase Kinases; Myocytes, Cardiac; Nickel; Nitriles; Oligopeptides; Peptides, Cyclic; Piperidines; Rats; Rats, Wistar; Receptors, Angiotensin; Receptors, Endothelin; RNA, Messenger; Signal Transduction; Sulfonamides	2003
Relative roles of endothelin-1 and angiotensin II in experimental post-ischaemic acute renal failure. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19, Issue:1 Topics: Acute Kidney Injury; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Infusions, Intravenous; Kidney; Losartan; Male; Models, Animal; Rats; Rats, Wistar; Reperfusion Injury; Sulfonamides	2004
Bosentan and losartan ameliorate acute renal failure associated with mild but not strong NO blockade. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2007, Volume: 22, Issue:9 Topics: Acute Kidney Injury; Animals; Antihypertensive Agents; Blood Pressure; Bosentan; Cardiac Output; Heart Rate; Infusions, Intravenous; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Regional Blood Flow; Sulfonamides; Vascular Resistance	2007
Role of angiotensin and endothelin in testicular ischemia reperfusion injury. International journal of urology : official journal of the Japanese Urological Association, 2012, Volume: 19, Issue:3 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Animals; Bosentan; Enalapril; Endothelin Receptor Antagonists; Endothelins; Losartan; Male; Malondialdehyde; Rats; Rats, Wistar; Reperfusion Injury; Statistics, Nonparametric; Sulfonamides; Testis	2012
Directly acting drugs prostacyclin or nitroglycerine and endothelin receptor blocker bosentan improve cell engraftment in rodent liver. Hepatology (Baltimore, Md.), 2013, Volume: 57, Issue:1 Topics: Animals; Bosentan; Cardiovascular Agents; Dipeptidyl Peptidase 4; Endothelin Receptor Antagonists; Epoprostenol; Hepatocytes; Lisinopril; Liver; Losartan; Nitroglycerin; Rats; Rats, Inbred F344; Sulfonamides	2013
Dual NEP/ECE inhibition improves endothelial function in mesenteric resistance arteries of 32-week-old SHR. Hypertension research : official journal of the Japanese Society of Hypertension, 2017, Volume: 40, Issue:8 Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzazepines; Bosentan; Endothelin-Converting Enzymes; Endothelium, Vascular; Enzyme Inhibitors; Hydralazine; Hypertension; Losartan; Mesenteric Arteries; Muscle Contraction; Neprilysin; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Protease Inhibitors; Rats; Rats, Inbred SHR; Sulfonamides; Vascular Resistance	2017