losartan and angiotensinogen

losartan has been researched along with angiotensinogen in 83 studies

Research

Studies (83)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	20 (24.10)	18.2507
2000's	36 (43.37)	29.6817
2010's	23 (27.71)	24.3611
2020's	4 (4.82)	2.80

Authors

Authors	Studies
Andries, M; Denef, C; Robberecht, W	1
Camargo, MJ; Gahnem, F; Laragh, JH; Sealey, JE; von Lutterotti, N	2
Basso, N; Cannata, MA; Kurnjek, ML; Ruiz, P	1
Hilgenfeldt, U; Schwind, S	1
Inagami, T; Inui, H; Iwai, N; Kato, H; Kimoto, K; Uchiyama, Y	1
Fukamizu, A; Hatae, T; Kajiwara, N; Murakami, K; Seo, MS; Sugimura, K; Sugiyama, F; Takahashi, S; Takimoto, E; Yagami, K	1
Inagami, T; Landon, EJ; Naruse, M; Piston, DW; Tamura, M; Tani, M	1
Hymel, A; Imig, JD; Navar, LG; Ono, H; von Thun, AM; Zou, LX	1
Burns, KD; Kontogiannis, J	1
Chen, X; Fogo, A; Ichikawa, I; Inagami, T; Matsusaka, T; Niimura, F; Nishimura, H; Okubo, S; Tsuchida, S; Utsunomiya, H	1
Amann, K; Bohlender, J; Drab, M; Ganten, D; Wagner, J; Wienen, W	1
Alhenc Gelas, F; Huang, W; Osborne-Pellegrin, MJ	1
Campbell, SE; Dhalla, AK; Kandala, JC; Katwa, LC; Sun, Y; Tyagi, SC; Weber, KT	1
Barrett, JD; Eggena, P; Hori, MT; Kamide, K; Tuck, ML; Zhu, JH	1
Bornstein, SR; Correa, FM; Ehrhart-Bornstein, M; Hilbers, U; Jöhren, O; Peters, J; Saavedra, JM	1
Brosius, FC; Izumo, S; Malhotra, R; Sadoshima, J	1
Bohlender, J; Dehmel, B; Ganten, D; Gross, V; Lippoldt, A; Luft, FC; Mervaala, E; Milia, AF	1
Johns, EJ; Moosavi, SM	1
Catterall, JF; Davisson, RL; Ding, Y; Sigmund, CD; Stec, DE	1
Burns, KD; Imig, JD; Kumar, D; Levine, DZ; Navar, LG; Wehbi, G; Zimpelmann, J	1
Cattran, DC; Duncan, JA; Floras, JS; Kang, AK; Lai, V; Miller, JA; Scholey, JW	1
Beltz, TG; Cassell, MD; Davisson, RL; Johnson, AK; Morimoto, S; Sigmund, CD	1
Cook, JL; Re, RN; Zhang, Z	1
Cassell, MD; Morimoto, S; Sigmund, CD	1
Afeche, SC; Bader, M; Baltatu, O; Barbosa, R; Campos, LA; Cipolla-Neto, J; José dos Santos, SH; Michelini, LC	1
Duggan, KA; Hodge, G; Ye, VZ	1
Barthelmebs, M; Coquard, C; Grima, M; Imbs, JL; Ingert, C	1
Bond, R; Brinsa, TA; Dell'Italia, L; Diwan, A; Evans, K; Flesch, M; Höper, A; Mann, DL; Peshock, R; Sivasubramanian, N; Spinale, FG; Wei, CC	1
Abboud, FM; Chapleau, MW; Davisson, RL; Hingtgen, SD; Ma, X; Sigmund, CD; Tian, X	1
Carlsson, PO; Lau, T; Leung, PS	1
Crescenzi, A; Michelini, LC; Sangaleti, CT	1
Casarini, DE; Cavaglieri, Rde C; Dellê, H; Dominguez, WV; Graciano, ML; Malheiros, DM; Noronha, IL	1
Chan, JS; Fantus, IG; Filep, JG; Fustier, P; Hamet, P; Hsieh, TJ; Ingelfinger, JR; Tang, SS; Wei, CC; Zhang, SL	1
Inokuchi, Y; Kawana, I; Kihara, M; Morohashi, T; Nagashima, Y; Umemura, S	1
Sarlos, S; Wilkinson-Berka, JL	1
Al-Saadi, N; Dechend, R; Fiebeler, A; Hilfenhaus, G; Jeng, AY; Luft, FC; Maser-Gluth, C; Meiners, S; Muller, DN; Nussberger, J; Rong, S; Shagdarsuren, E; Webb, RL; Wellner, M	1
Fontanazza, A; Martarelli, D; Pediconi, D; Pompei, P	1
An, CS; Cui, XJ; Jung, KW; Kang, HW; Kang, JS; Kim, JL; Kim, MJ; Lee, DH; Lee, YJ; Park, DB	1
Beltz, TG; Bianco, RA; Johnson, AK; Lavoie, JL; Liu, X; Sigmund, CD	1
Brezniceanu, ML; Chan, JS; Filep, JG; Guo, DF; Hamet, P; Hsieh, TJ; Ingelfinger, JR; Liu, F; Liu, Q; Sachetelli, S; Sigmund, CD; Zhang, SL	1
Boustany-Kari, CM; Cassis, LA; Daugherty, A; Lu, H	1
Aghaeishahsavari, M; Argani, H; Ghorbanihaghjo, A; Noroozianavval, M; Rashtchizadeh, N; Veisi, P	1
Fujigaki, Y; Fukasawa, H; Hishida, A; Kato, A; Nakagawa, T; Nakamura, Y; Ohashi, N; Suzuki, F; Suzuki, H; Yamamoto, T	1
Dechend, R; Dietz, R; Fiebeler, A; Fischer, R; Gapelyuk, A; Gratze, P; Gruner, A; Gruner, K; Luft, FC; Muller, DN; Qadri, F; Schirdewan, A; Shagdarsuren, E; Wellner, M	1
Aghaeishahsavari, M; Argani, H; Ghorbanihaghjo, A; Hamzeiy, H; Jabbarpourbonyadi, M; Noroozianavval, M; Rashtchizadeh, N; Veisi, P	1
Feng, D; Li, K; Wang, L; Wu, Q; Yao, S	1
Debnam, ES; Leung, PS; Wong, TP	1
Bacurau, AV; Brum, PC; Casarini, DE; Coelho, MA; Evangelista, FS; Ferreira, JC; Krieger, JE; Oliveira, EM	1
Brezniceanu, ML; Chan, JS; Chénier, I; Filep, JG; Ingelfinger, JR; Liu, F; Sachetelli, S; Wei, CC; Zhang, SL	1
Donner, K; Fodstad, H; Hannila-Handelberg, T; Hiltunen, TP; Kontula, K; Suonsyrjä, T	1
Chen, W; Deans, T; Gratze, P; Guzik, TJ; Harrison, DG; Hoch, NE; Maalouf, SA; Weyand, C	1
De Mello, WC; Gerena, Y	1
Arbeeny, C; Chen, Y; Deb, DK; Kong, J; Li, G; Li, YC; Ning, G; Sabbagh, Y; Strugnell, S; Wang, Y; Zhang, Y; Zhang, Z	1
Huang, Y; Lu, LM; Xue, H; Yao, T; Yuan, P; Zhou, L	1
Chen, S; Chen, Y; Li, G; Olson, JE; Sigmund, CD; Wang, J; Zhang, W	1
Han, HJ; Kim, YH; Lee, YJ; Ryu, JM	1
An, J; Kimura, A; Kuba, K; Nakajima, T	1
Huang, Y; Lu, LM; Ni, J; Xue, H; Yu, C; Yuan, P; Zhou, L	1
Davis, D; Iliescu, R; Reckelhoff, JF; Romero, DG; Yanes, LL; Zhang, H	1
Chou, PC; Hsiao, PJ; Hsieh, TJ; Hung, WW; Lin, KD; Lin, T; Shin, SJ	1
Cho, S; Huh, W; Jang, HR; Kim, DJ; Kim, SR; Kim, YG; Lee, JE; Lee, YJ; Oh, HY	1
Asami, M; Kato, J; Kitamura, K; Kuwasako, K; Nagata, S	1
Chitravanshi, VC; Proddutur, A; Sapru, HN	1
Chan, JS; Chenier, I; Filep, JG; Godin, N; Ingelfinger, JR; Liu, F; Lo, CS; Maachi, H; Shi, Y; Zhang, SL	1
Chang, SC; Sun, CY; Wu, MS	1
Arakawa, H; Kawabe, K; Sapru, HN	1
Huang, Y; Li, C; Liu, J; Lu, L; Ni, J; Shao, D; Shen, Y; Wang, R; Wang, Z; Xue, H; Yu, C; Yuan, P; Zhang, W; Zhou, L	1
Kawabe, K; Kawabe, T; Sapru, HN	1
Gorman, JL; Haas, TL; Hasanee, A; Liu, ST; Olenich, S; Olfert, IM; Shariati, K; Slopack, D	1
Chen, C; Chen, Y; Li, Z; Peng, M; Wang, Y; Zhang, F; Zhang, Z	1
Baiardi, G; Bregonzio, C; Cancela, LM; Gerez de Burgos, NM; Imboden, H; Marchese, NA; Paz, MC; Stroppa, MM	1
A, L; Bai, Q; Liang, Y; Wang, Y; Wu, H; Zheng, D; Zheng, Y; Zhuang, Z	1
Deng, XL; Ma, XZ; Wang, HF; Wang, LP; Zhao, LM; Zhou, DX	1
Mishra, PK; Nandi, SS; Patel, KP; Sharma, NM; Zheng, H	1
Chianca, D; de Abreu, ARR; de Menezes, RCA; de Souza, AMA; Ji, H; Mesquita, LBT; Pai, AV; Sandberg, K; West, CA	1
Cohn, DM; Gatineau, E; Gong, M; Loria, AS; Poglitsch, M; Yiannikouris, F	1
Guan, Y; Kobara, H; Kobori, H; Li, L; Masaki, T; Morishita, A; Nakano, D; Nishiyama, A	1
Calvo, AM; Cano, IP; Cestari, TM; Colombini-Ishikiriama, BL; Dionisio, TJ; Faria, FAC; Santos, CF; Siqueira, WL	1
Bovée, DM; Clahsen-van Groningen, MC; Danser, AHJ; Domenig, O; Foster, D; Garrelds, IM; Hoorn, EJ; Huang, S; Kim, JB; Lu, X; Melton, L; Poglitsch, M; Ren, L; Uijl, E; van Veghel, R; Zlatev, I	1
Chang, J; Du, J; Ge, X; Li, X; Li, YC; Liu, W; Nie, H; Sun, Y; Wei, X; Xun, Z	1
Daugherty, A; Franklin, MK; Howatt, DA; Lu, HS; Moorleghen, JJ; Mullick, AE; Ohno-Urabe, S; Sawada, H; Ye, D	1
Aicher, BO; Au, DT; Daugherty, A; Franklin, MK; Hampton, B; Howatt, DA; Lu, HS; Migliorini, M; Moorleghen, JJ; Mullick, AE; Muratoglu, SC; Ni, F; Sawada, H; Strickland, DK; Ucuzian, AA; Wang, P; Wani, MM; Zhang, JM	1

Trials

5 trial(s) available for losartan and angiotensinogen

Article	Year
Enalapril and losartan affect lipid peroxidation in renal transplant recipients with renin-angiotensin system polymorphisms. Clinical biochemistry, 2007, Volume: 40, Issue:3-4 Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Cross-Over Studies; Enalapril; Female; Humans; Kidney Transplantation; Lipid Peroxidation; Losartan; Male; Malondialdehyde; Peptidyl-Dipeptidase A; Polymerase Chain Reaction; Polymorphism, Genetic; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Sequence Analysis, DNA	2007
Urinary angiotensinogen as a marker of intrarenal angiotensin II activity associated with deterioration of renal function in patients with chronic kidney disease. Journal of the American Society of Nephrology : JASN, 2007, Volume: 18, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angiotensin II; Angiotensinogen; Antihypertensive Agents; Biomarkers; Collagen Type I; Female; Humans; Kidney; Losartan; Male; Middle Aged; Renal Insufficiency, Chronic	2007
Renin-angiotensin system polymorphisms and hemoglobin level in renal allografts: a comparative study between losartan and enalapril. Transplantation proceedings, 2007, Volume: 39, Issue:4 Topics: Adult; Angiotensinogen; Antihypertensive Agents; Enalapril; Female; Hemoglobins; Humans; Kidney Transplantation; Losartan; Male; Peptidyl-Dipeptidase A; Polymerase Chain Reaction; Polymorphism, Genetic; Renin-Angiotensin System	2007
Renin-angiotensin system and alpha-adducin gene polymorphisms and their relation to responses to antihypertensive drugs: results from the GENRES study. American journal of hypertension, 2009, Volume: 22, Issue:2 Topics: Adult; Amlodipine; Angiotensinogen; Antihypertensive Agents; Bisoprolol; Blood Pressure; Calmodulin-Binding Proteins; Humans; Hydrochlorothiazide; Losartan; Male; Middle Aged; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Receptor, Angiotensin, Type 1; Renin-Angiotensin System	2009
Effect of losartan on proteinuria and urinary angiotensinogen excretion in non-diabetic patients with chronic kidney disease. Postgraduate medical journal, 2011, Volume: 87, Issue:1032 Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Kidney Failure, Chronic; Losartan; Male; Middle Aged; Proteinuria; Renin-Angiotensin System	2011

Other Studies

78 other study(ies) available for losartan and angiotensinogen

Article	Year
Stimulation of prolactin secretion from rat pituitary by luteinizing hormone-releasing hormone: evidence against mediation by angiotensin II acting through a (Sar1-Ala8)-angiotensin II-sensitive receptor. Neuroendocrinology, 1992, Volume: 56, Issue:2 Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Animals; Biphenyl Compounds; Captopril; Cells, Cultured; Female; Gonadotropin-Releasing Hormone; Imidazoles; Losartan; Male; Pituitary Gland; Prolactin; Rats; Rats, Wistar; Receptors, Angiotensin; Saralasin; Tetrazoles	1992
Angiotensinogen depletion by high renin levels in hypertensive rats: no evidence for tonic stimulation of angiotensinogen by angiotensin II. Journal of hypertension, 1995, Volume: 13, Issue:1 Topics: Administration, Oral; Angiotensin II; Angiotensinogen; Animals; Biphenyl Compounds; Diet; Hypertension; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Renin; Sodium Chloride, Dietary; Tetrazoles	1995
Angiotensinogen dependency of blood pressure in two high-renin hypertensive rat models. American journal of hypertension, 1994, Volume: 7, Issue:10 Pt 1 Topics: Angiotensin II; Angiotensinogen; Animals; Biphenyl Compounds; Blood Pressure; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Renin; Sodium, Dietary; Tetrazoles	1994
Effect of EXP 3174 on blood pressure of normoreninemic renal hypertensive rats. Hypertension (Dallas, Tex. : 1979), 1995, Volume: 25, Issue:2 Topics: Angiotensinogen; Animals; Antihypertensive Agents; Arteries; Blood Pressure; Hypertension, Renal; Imidazoles; Injections, Intravenous; Injections, Intraventricular; Losartan; Male; Rats; Rats, Wistar; Renin; Tetrazoles	1995
Angiotensin II is the mediator of the increase in hepatic angiotensinogen synthesis after bilateral nephrectomy. The American journal of physiology, 1993, Volume: 265, Issue:3 Pt 1 Topics: Adrenalectomy; Angiotensin II; Angiotensinogen; Animals; Atenolol; Biphenyl Compounds; Imidazoles; Kidney; Liver; Losartan; Male; Nephrectomy; Osmolar Concentration; Postoperative Period; Rats; Rats, Wistar; Renin; Tetrazoles; Time Factors	1993
Regulation of vascular angiotensin release. Hypertension (Dallas, Tex. : 1979), 1993, Volume: 21, Issue:4 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Animals; Aorta; Base Sequence; Biphenyl Compounds; Dexamethasone; Ethinyl Estradiol; Hindlimb; Imidazoles; Losartan; Male; Molecular Sequence Data; Muscle, Smooth, Vascular; Muscles; Nephrectomy; Oligodeoxyribonucleotides; Perfusion; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Renin; RNA, Messenger; Tetrazoles; Triiodothyronine	1993
Chimeric renin-angiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes. The Journal of biological chemistry, 1993, Jun-05, Volume: 268, Issue:16 Topics: Angiotensin I; Angiotensin II; Angiotensinogen; Animals; Biphenyl Compounds; Blood Pressure; Captopril; Dipeptides; Humans; Imidazoles; Losartan; Male; Mice; Mice, Transgenic; Morpholines; Recombinant Proteins; Renin; Renin-Angiotensin System; Tetrazoles	1993
Ouabain increases aldosterone release from bovine adrenal glomerulosa cells: role of renin-angiotensin system. The American journal of physiology, 1996, Volume: 270, Issue:1 Pt 1 Topics: Aldosterone; Angiotensinogen; Animals; Biphenyl Compounds; Calcium; Cattle; Cells, Cultured; Culture Media; Culture Media, Serum-Free; Horses; Imidazoles; Intracellular Membranes; Losartan; Mineralocorticoid Receptor Antagonists; Ouabain; Rats; Renin-Angiotensin System; Sheep; Swine; Tetrazoles; Zona Glomerulosa	1996
Receptor-mediated intrarenal angiotensin II augmentation in angiotensin II-infused rats. Hypertension (Dallas, Tex. : 1979), 1996, Volume: 28, Issue:4 Topics: Angiotensin II; Angiotensinogen; Animals; Biphenyl Compounds; Hypertension; Imidazoles; Kidney; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin; Tetrazoles	1996
Role of AT1 angiotensin II receptors in renal ischemic injury. The American journal of physiology, 1998, Volume: 274, Issue:1 Topics: Angiotensin II; Angiotensinogen; Animals; Creatinine; Ischemia; Kidney; Kidney Cortex; Kidney Medulla; Kidney Tubules, Proximal; Losartan; Male; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reference Values; Reperfusion; RNA, Messenger; Transcription, Genetic; Up-Regulation	1998
Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. The Journal of clinical investigation, 1998, Feb-15, Volume: 101, Issue:4 Topics: Adrenal Glands; Anesthetics; Angiotensin II; Angiotensinogen; Animals; Benzimidazoles; beta-Galactosidase; Biphenyl Compounds; Blood Pressure; Imidazoles; Infusions, Intravenous; Kidney; Losartan; Mice; Mice, Knockout; Myocardium; Phenotype; Pyridines; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Saralasin; Staining and Labeling; Tetrazoles; Thiopental; Zygote	1998
Effects of AT1 receptor blockade on blood pressure and the renin-angiotensin system in spontaneously hypertensive rats of the stroke prone strain. Clinical and experimental hypertension (New York, N.Y. : 1993), 1998, Volume: 20, Issue:2 Topics: Albuminuria; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Blood Pressure; Captopril; Cerebrovascular Disorders; Gene Expression; Hypertension; Kidney; Losartan; Male; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin; Renin-Angiotensin System; RNA, Messenger; Telmisartan	1998
Protection of the arterial internal elastic lamina by inhibition of the renin-angiotensin system in the rat. Circulation research, 1998, May-04, Volume: 82, Issue:8 Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Rupture; Benzimidazoles; Blood Pressure; Body Weight; Calcium Channel Blockers; Collagen; Elastic Tissue; Elastin; Enalapril; Heart; Heart Rate; Losartan; Male; Mibefradil; Muscle, Smooth, Vascular; Organ Size; Peptidyl-Dipeptidase A; Rats; Rats, Inbred BN; Renin; Renin-Angiotensin System; Tetrahydronaphthalenes	1998
Pouch tissue and angiotensin peptide generation. Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:7 Topics: Angiotensin I; Angiotensin II; Angiotensinogen; Angiotensins; Animals; Aspartic Acid Endopeptidases; Cathepsin D; Collagen; Gene Expression; Imidazoles; Lisinopril; Losartan; Myocardium; Peptide Biosynthesis; Peptides; Peptidyl-Dipeptidase A; Pyridines; Rats; Renin; Transforming Growth Factor beta	1998
Insulin-mediated growth in aortic smooth muscle and the vascular renin-angiotensin system. Hypertension (Dallas, Tex. : 1979), 1998, Volume: 32, Issue:3 Topics: Angiotensin II; Angiotensinogen; Animals; Antihypertensive Agents; Aorta; Captopril; Cell Division; Cells, Cultured; Insulin; Losartan; Male; Muscle Development; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Renin-Angiotensin System; Serine Proteinase Inhibitors; Thymidine; Vasoconstrictor Agents	1998
Local renin-angiotensin system is involved in K+-induced aldosterone secretion from human adrenocortical NCI-H295 cells. Hypertension (Dallas, Tex. : 1979), 1999, Volume: 33, Issue:4 Topics: Adrenal Cortex; Aldosterone; Angiotensinogen; Captopril; Cells, Cultured; Humans; Losartan; Peptidyl-Dipeptidase A; Potassium; Renin; Renin-Angiotensin System	1999
Mechanical stretch and angiotensin II differentially upregulate the renin-angiotensin system in cardiac myocytes In vitro. Circulation research, 1999, Jul-23, Volume: 85, Issue:2 Topics: Angiotensin II; Angiotensinogen; Animals; Anti-Arrhythmia Agents; Antisense Elements (Genetics); Blotting, Southern; Cells, Cultured; Fibroblasts; Gene Expression; Heart Ventricles; Imidazoles; In Vitro Techniques; Iodine Radioisotopes; Losartan; Muscle Fibers, Skeletal; Myocardial Contraction; Myocardium; Peptidyl-Dipeptidase A; Pyridines; Radioligand Assay; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Renin; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stress, Mechanical	1999
Angiotensin-converting enzyme inhibition and AT1 receptor blockade modify the pressure-natriuresis relationship by additive mechanisms in rats with human renin and angiotensinogen genes. Journal of the American Society of Nephrology : JASN, 1999, Volume: 10, Issue:8 Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Animals, Genetically Modified; Antihypertensive Agents; Blood Pressure; Cilazapril; Diuresis; Humans; Hypertrophy, Left Ventricular; In Situ Hybridization; Kidney; Losartan; Male; Natriuresis; Nucleic Acid Hybridization; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin; Ribonucleases	1999
Effect of renal perfusion pressure on renal function, renin release and renin and angiotensinogen gene expression in rats. The Journal of physiology, 1999, Oct-01, Volume: 520 Pt 1 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Animals; Blood Pressure; Blotting, Northern; Feedback; Gene Expression; Glyceraldehyde-3-Phosphate Dehydrogenases; In Situ Hybridization; Inulin; Kidney; Losartan; Rats; Rats, Wistar; Renal Circulation; Renin	1999
Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice. Physiological genomics, 1999, Jul-15, Volume: 1, Issue:1 Topics: Angiotensin Receptor Antagonists; Angiotensinogen; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Gene Targeting; Humans; Hypertension; Kidney; Losartan; Mice; Mice, Transgenic; Organ Specificity; Promoter Regions, Genetic; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; RNA, Messenger	1999
Early diabetes mellitus stimulates proximal tubule renin mRNA expression in the rat. Kidney international, 2000, Volume: 58, Issue:6 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Animals; Antihypertensive Agents; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Gene Expression; Hypertrophy; Hypoglycemic Agents; Insulin; Kidney Tubules, Proximal; Losartan; Male; Nephritis, Interstitial; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin; Renin-Angiotensin System; RNA, Messenger	2000
Effect of oral contraceptives on the renin angiotensin system and renal function. American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 280, Issue:3 Topics: Adult; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Blood Pressure; Contraceptives, Oral; Female; Glomerular Filtration Rate; Humans; Inulin; Kidney; Losartan; p-Aminohippuric Acid; Premenopause; Renal Circulation; Renin; Renin-Angiotensin System; Vascular Resistance	2001
Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter. Circulation research, 2001, Aug-17, Volume: 89, Issue:4 Topics: Angiotensinogen; Animals; Astrocytes; Blood Pressure; Brain; Dose-Response Relationship, Drug; Drinking; Gene Expression; Glial Fibrillary Acidic Protein; Humans; Hypertension; Injections, Intravenous; Injections, Intraventricular; Losartan; Mice; Mice, Transgenic; Neurons; Organ Specificity; Promoter Regions, Genetic; Renin; RNA, Messenger; Subfornical Organ; Transgenes; Water-Electrolyte Balance	2001
In vitro evidence for an intracellular site of angiotensin action. Circulation research, 2001, Dec-07, Volume: 89, Issue:12 Topics: Alternative Splicing; Angiotensin Receptor Antagonists; Angiotensinogen; Angiotensins; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Bromodeoxyuridine; Carcinoma, Hepatocellular; Cell Division; Clone Cells; Intracellular Fluid; Losartan; Mitotic Index; Mutagenesis, Site-Directed; Oligonucleotides, Antisense; Peptidyl-Dipeptidase A; Polymerase Chain Reaction; Rats; Receptors, Angiotensin; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Renin; Sequence Deletion; Tetrazoles; Transfection; Tumor Cells, Cultured	2001
The brain renin-angiotensin system in transgenic mice carrying a highly regulated human renin transgene. Circulation research, 2002, Jan-11, Volume: 90, Issue:1 Topics: Alternative Splicing; Angiotensinogen; Animals; Antihypertensive Agents; Arginine Vasopressin; Blood Pressure; Brain; Gene Expression; Hexamethonium; Humans; Immunohistochemistry; Losartan; Mice; Mice, Transgenic; Renin; Renin-Angiotensin System; RNA, Messenger	2002
Locally synthesized angiotensin modulates pineal melatonin generation. Journal of neurochemistry, 2002, Volume: 80, Issue:2 Topics: Angiotensin Receptor Antagonists; Angiotensinogen; Angiotensins; Animals; Animals, Genetically Modified; Antihypertensive Agents; Arylamine N-Acetyltransferase; In Vitro Techniques; Losartan; Melatonin; Pineal Gland; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Tryptophan Hydroxylase	2002
Dysregulation of angiotensin II synthesis is associated with salt sensitivity in the spontaneous hypertensive rat. Acta physiologica Scandinavica, 2002, Volume: 174, Issue:3 Topics: Aldosterone; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Blood Pressure; Hypertension; Losartan; Male; Peptidyl-Dipeptidase A; Rats; Rats, Inbred SHR; Receptors, Angiotensin; Renin; Sodium Chloride, Dietary	2002
Contribution of angiotensin II internalization to intrarenal angiotensin II levels in rats. American journal of physiology. Renal physiology, 2002, Volume: 283, Issue:5 Topics: Angiotensin I; Angiotensin II; Angiotensinogen; Animals; Antihypertensive Agents; Diet, Sodium-Restricted; Kidney Cortex; Kidney Medulla; Losartan; Male; Peptidyl-Dipeptidase A; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Renin; Renin-Angiotensin System; Sodium Chloride, Dietary	2002
Activation and functional significance of the renin-angiotensin system in mice with cardiac restricted overexpression of tumor necrosis factor. Circulation, 2003, Aug-05, Volume: 108, Issue:5 Topics: Age Factors; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Animals; Body Weight; Cardiomegaly; Collagen; Hemodynamics; Losartan; Mice; Mice, Transgenic; Myocardium; Organ Size; Organ Specificity; Peptidyl-Dipeptidase A; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin; Renin-Angiotensin System; RNA, Messenger; Tumor Necrosis Factor-alpha; Ventricular Remodeling	2003
Ganglionic action of angiotensin contributes to sympathetic activity in renin-angiotensinogen transgenic mice. Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:2 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Blood Pressure; Chlorisondamine; Ganglia, Sympathetic; Ganglionic Blockers; Humans; Hypertension; Kidney; Losartan; Mice; Mice, Transgenic; Renin; Renin-Angiotensin System; Sympathetic Nervous System	2004
Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets. Diabetologia, 2004, Volume: 47, Issue:2 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensinogen; Animals; Blotting, Western; Dose-Response Relationship, Drug; Gene Expression; Glucose; Imidazoles; Immunohistochemistry; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Losartan; Male; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Peptidyl-Dipeptidase A; Proinsulin; Protein Biosynthesis; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction	2004
Endogenous angiotensin and pressure modulate brain angiotensinogen and AT1A mRNA expression. Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:2 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Blood Pressure; Brain Stem; Gene Expression; Hypertension; Losartan; Male; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; RNA, Messenger; Solitary Nucleus	2004
Intrarenal Renin-Angiotensin system is upregulated in experimental model of progressive renal disease induced by chronic inhibition of nitric oxide synthesis. Journal of the American Society of Nephrology : JASN, 2004, Volume: 15, Issue:7 Topics: Albumins; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Angiotensins; Animals; Antihypertensive Agents; Blood Pressure; Blotting, Western; Cathepsin D; Enalapril; Enzyme Inhibitors; Glomerulonephritis; Immunohistochemistry; Kidney; Kidney Diseases; Losartan; Male; Mycophenolic Acid; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Renin; Renin-Angiotensin System; Time Factors; Up-Regulation	2004
Reactive oxygen species blockade and action of insulin on expression of angiotensinogen gene in proximal tubular cells. The Journal of endocrinology, 2004, Volume: 183, Issue:3 Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Azaserine; Cell Line; Gene Expression Regulation; Glucose; Imidazoles; Indicators and Reagents; Indoles; Insulin; Kidney Tubules, Proximal; Losartan; Maleimides; Perindopril; Protein Kinase C; Pyridines; Rats; Reactive Oxygen Species; Renin	2004
Amelioration of 2,4,6-trinitrobenzene sulphonic acid induced colitis in angiotensinogen gene knockout mice. Gut, 2005, Volume: 54, Issue:3 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Colitis; Colon; Cytokines; Immunity, Mucosal; Intestinal Mucosa; Losartan; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Renin-Angiotensin System; Trinitrobenzenesulfonic Acid; Weight Loss	2005
The renin-angiotensin system and the developing retinal vasculature. Investigative ophthalmology & visual science, 2005, Volume: 46, Issue:3 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Animals, Genetically Modified; Autoradiography; Immunoenzyme Techniques; Lisinopril; Losartan; Neovascularization, Physiologic; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin; Renin-Angiotensin System; Retinal Ganglion Cells; Retinal Vessels	2005
Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage. Circulation, 2005, Jun-14, Volume: 111, Issue:23 Topics: Adrenal Glands; Adrenalectomy; Aldosterone; Angiotensin II; Angiotensinogen; Animals; Animals, Genetically Modified; Cytochrome P-450 CYP11B2; Enzyme Inhibitors; Fibrosis; Heart Diseases; Humans; Inflammation; Kidney Diseases; Losartan; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Renin	2005
Effects of losartan and irbesartan administration on brain angiotensinogen mRNA levels. European journal of pharmacology, 2005, Dec-28, Volume: 528, Issue:1-3 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Biphenyl Compounds; Brain; Dose-Response Relationship, Drug; Intubation, Gastrointestinal; Irbesartan; Losartan; Male; Rats; Rats, Inbred WKY; RNA, Messenger; Tetrazoles; Time Factors	2005
Chronic blockade of the angiotensin II receptor has a differential effect on adipose and vascular PAI-1 in OLETF rats. Diabetes research and clinical practice, 2006, Volume: 73, Issue:1 Topics: Adipose Tissue; Angiotensin Receptor Antagonists; Angiotensinogen; Animals; Aorta, Thoracic; Diabetes Mellitus, Type 1; Losartan; Male; Mesentery; Plasminogen Activator Inhibitor 1; Rats; Rats, Inbred OLETF; Receptors, Angiotensin; Tumor Necrosis Factor-alpha	2006
Evidence supporting a functional role for intracellular renin in the brain. Hypertension (Dallas, Tex. : 1979), 2006, Volume: 47, Issue:3 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Blood Pressure; Brain; Drinking; Glial Fibrillary Acidic Protein; Humans; Injections, Intraventricular; Intracellular Membranes; Losartan; Mice; Mice, Transgenic; Promoter Regions, Genetic; Renin	2006
RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney. Kidney international, 2006, Volume: 69, Issue:6 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Blood Pressure; Blotting, Western; DNA, Complementary; Female; Gene Expression Regulation; Hypertension; Immunohistochemistry; Kidney; Kidney Diseases; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Perindopril; Proteins; Proteinuria; Rats; Renin-Angiotensin System	2006
Angiotensin II increases adipose angiotensinogen expression. American journal of physiology. Endocrinology and metabolism, 2007, Volume: 292, Issue:5 Topics: Adipose Tissue; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Blotting, Western; Gene Expression Regulation; Liver; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, LDL; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger	2007
Angiotensin II-induced sudden arrhythmic death and electrical remodeling. American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:2 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Animals, Genetically Modified; Blood Pressure; Cardiac Pacing, Artificial; Cardiomegaly; Connexin 43; Death, Sudden, Cardiac; Disease Models, Animal; Electrocardiography; Heart Conduction System; Hypertension; Losartan; Male; Myocardium; Rats; Rats, Sprague-Dawley; Renin; RNA, Messenger; Shal Potassium Channels; Tachycardia, Ventricular; Telemetry; Time Factors; Ventricular Remodeling	2007
Losartan attenuates ventilator-induced lung injury. The Journal of surgical research, 2008, Volume: 145, Issue:1 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Apoptosis; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Losartan; Lung; Male; Neutrophil Infiltration; Peroxidase; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Respiration, Artificial; Respiratory Distress Syndrome; RNA, Messenger	2008
Involvement of an enterocyte renin-angiotensin system in the local control of SGLT1-dependent glucose uptake across the rat small intestinal brush border membrane. The Journal of physiology, 2007, Oct-15, Volume: 584, Issue:Pt 2 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Autocrine Communication; Blotting, Western; Enterocytes; Glucose; Ileum; Immunohistochemistry; In Vitro Techniques; Jejunum; Leucine; Losartan; Male; Microvilli; Peptidyl-Dipeptidase A; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; RNA, Messenger; Sodium-Glucose Transporter 1	2007
The role of local and systemic renin angiotensin system activation in a genetic model of sympathetic hyperactivity-induced heart failure in mice. American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 294, Issue:1 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Blood Pressure; Disease Models, Animal; Heart Failure; Heart Rate; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Genetic; Myocytes, Cardiac; Norepinephrine; Physical Conditioning, Animal; Receptors, Adrenergic, alpha-2; Renin-Angiotensin System; Sympathetic Nervous System	2008
Overexpression of angiotensinogen increases tubular apoptosis in diabetes. Journal of the American Society of Nephrology : JASN, 2008, Volume: 19, Issue:2 Topics: Albuminuria; Angiotensinogen; Animals; Antihypertensive Agents; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Blood Glucose; Cell Line, Transformed; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Hydralazine; Hypertension, Renal; Hypoglycemic Agents; Insulin; Kidney Tubules, Proximal; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Perindopril; Rats; Renin-Angiotensin System	2008
Regulation of T-cell function by endogenously produced angiotensin II. American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 296, Issue:2 Topics: Adoptive Transfer; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensinogen; Animals; Autocrine Communication; Blood Pressure; Catalase; Cells, Cultured; Homeodomain Proteins; Imidazoles; Infusion Pumps, Implantable; Losartan; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Peptidyl-Dipeptidase A; Polyethylene Glycols; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin; Renin-Angiotensin System; Superoxide Dismutase; Superoxides; T-Lymphocytes; Time Factors; Tumor Necrosis Factor-alpha	2009
Prolonged exposure of cardiac cells to renin plus angiotensinogen reduces intracellular renin in the failing heart. On the role of angiotensin II-AT1 complex internalization. Regulatory peptides, 2009, Jun-05, Volume: 155, Issue:1-3 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Cardiomyopathies; Cells, Cultured; Cricetinae; Flow Cytometry; Heart; Losartan; Male; Microscopy, Fluorescence; Myocytes, Cardiac; Receptor, Angiotensin, Type 1; Renin; Serine Proteinase Inhibitors	2009
Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: strong synergism with AT1 receptor antagonist. American journal of physiology. Renal physiology, 2009, Volume: 297, Issue:3 Topics: Albuminuria; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Cytokines; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ergocalciferols; Fibrosis; Glomerular Basement Membrane; Inflammation Mediators; Losartan; Macrophages; Mice; Mice, Inbred DBA; Podocytes; Renin; Renin-Angiotensin System; Time Factors; Vitamins	2009
Effect of adrenotensin on cell proliferation is mediated by angiotensin II in cultured rat mesangial cells. Acta pharmacologica Sinica, 2009, Volume: 30, Issue:8 Topics: Adrenomedullin; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Cell Line; Cell Proliferation; Collagen Type IV; Gene Expression Regulation; Losartan; Mesangial Cells; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Receptor, Angiotensin, Type 1; Renin; RNA, Messenger; Transforming Growth Factor beta1	2009
Ischemia-induced brain damage is enhanced in human renin and angiotensinogen double-transgenic mice. American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 297, Issue:5 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Blood Pressure; Brain; Brain Ischemia; Cell Death; Disease Models, Animal; Humans; Infarction, Middle Cerebral Artery; Losartan; Male; Mice; Mice, Transgenic; Receptor, Angiotensin, Type 1; Regional Blood Flow; Renin; Severity of Illness Index; Signal Transduction	2009
Fibronectin synthesis by high glucose level mediated proliferation of mouse embryonic stem cells: Involvement of ANG II and TGF-beta1. Journal of cellular physiology, 2010, Volume: 223, Issue:2 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Calcium Signaling; Cell Count; Cell Proliferation; DNA Replication; Embryonic Stem Cells; Fibronectins; Glucose; Hyperglycemia; JNK Mitogen-Activated Protein Kinases; Losartan; Mice; Phosphorylation; Protein Kinase C; Receptor, Angiotensin, Type 1; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta1	2010
Losartan inhibits LPS-induced inflammatory signaling through a PPARgamma-dependent mechanism in human THP-1 macrophages. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:8 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Atherosclerosis; Cell Line; Gene Expression; Humans; Hypertension; I-kappa B Proteins; Inflammation; Lipopolysaccharides; Losartan; Macrophages; Monocytes; Phosphorylation; PPAR gamma; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System; Signal Transduction	2010
Angiotensin AT1 receptor activation mediates high glucose-induced epithelial-mesenchymal transition in renal proximal tubular cells. Clinical and experimental pharmacology & physiology, 2010, Volume: 37, Issue:9 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Cadherins; Cell Line; Epithelial Cells; Epithelial-Mesenchymal Transition; Extracellular Matrix; Fibronectins; Glucose; Hyperglycemia; Kidney; Kidney Tubules, Proximal; Losartan; Peptidyl-Dipeptidase A; Rats; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; RNA, Messenger; Transforming Growth Factor beta1	2010
Postmenopausal hypertension: role of the Renin-Angiotensin system. Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:3 Topics: Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Blood Pressure; Female; Hypertension; Kidney; Losartan; Peptidyl-Dipeptidase A; Rats; Rats, Inbred SHR; Renin; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; Telemetry	2010
Blockade of the renin-angiotensin system ameliorates apelin production in 3T3-L1 adipocytes. Cardiovascular drugs and therapy, 2011, Volume: 25, Issue:1 Topics: 3T3-L1 Cells; Adipocytes; Adipokines; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Apelin; Captopril; Cells, Cultured; Imidazoles; Intercellular Signaling Peptides and Proteins; Lipid Metabolism; Losartan; Mice; Perindopril; Pyridines; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin; Renin-Angiotensin System; RNA, Messenger	2011
Plasma and tissue concentrations of proangiotensin-12 in rats treated with inhibitors of the renin-angiotensin system. Hypertension research : official journal of the Japanese Society of Hypertension, 2012, Volume: 35, Issue:2 Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Blood Pressure; Body Weight; Imidazolidines; Kidney; Losartan; Male; Myocardium; Organ Size; Peptide Fragments; Radioimmunoassay; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin; Renin-Angiotensin System	2012
Cardiovascular actions of angiotensin-(1-12) in the hypothalamic paraventricular nucleus of the rat are mediated via angiotensin II. Experimental physiology, 2012, Volume: 97, Issue:9 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Angiotensins; Animals; Blood Pressure; Cardiovascular System; Chymases; Heart Rate; Imidazoles; Kidney; Losartan; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin; Sympathetic Nervous System; Vagotomy; Vagus Nerve	2012
Dual RAS blockade normalizes angiotensin-converting enzyme-2 expression and prevents hypertension and tubular apoptosis in Akita angiotensinogen-transgenic mice. American journal of physiology. Renal physiology, 2012, Apr-01, Volume: 302, Issue:7 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Gene Expression; Hypertension; Kidney; Kidney Tubules, Proximal; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nephrosclerosis; Peptidyl-Dipeptidase A; Perindopril; Rats; Renin-Angiotensin System; Transgenes	2012
Uremic toxins induce kidney fibrosis by activating intrarenal renin-angiotensin-aldosterone system associated epithelial-to-mesenchymal transition. PloS one, 2012, Volume: 7, Issue:3 Topics: Angiotensinogen; Animals; Cresols; Epithelial-Mesenchymal Transition; Fibrosis; Gene Expression Regulation; Indican; Kidney; Kidney Failure, Chronic; Kidney Tubules; Losartan; Male; Mice; Models, Biological; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System; Snail Family Transcription Factors; Sulfuric Acid Esters; Transcription Factors; Transforming Growth Factor beta1; Uremia	2012
Angiotensin-(1-12) in the rostral ventrolateral medullary pressor area of the rat elicits sympathoexcitatory responses. Experimental physiology, 2013, Volume: 98, Issue:1 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Arterial Pressure; Captopril; Chymases; Imidazoles; Losartan; Male; Medulla Oblongata; Oligopeptides; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Peptidyl-Dipeptidase A; Phenylethanolamine N-Methyltransferase; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Sympathetic Nervous System	2013
H(2)S inhibits hyperglycemia-induced intrarenal renin-angiotensin system activation via attenuation of reactive oxygen species generation. PloS one, 2013, Volume: 8, Issue:9 Topics: Acetophenones; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Blood Glucose; Cell Proliferation; Cells, Cultured; Collagen Type IV; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Diabetes Mellitus, Experimental; Glucose; Hydrogen Sulfide; Hyperglycemia; Kidney; Losartan; Mesangial Cells; NADPH Oxidases; Onium Compounds; Peptidyl-Dipeptidase A; Rats; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; RNA, Messenger; Transforming Growth Factor beta1	2013
Cardiovascular effect of angiotensin-(1-12) in the caudal ventrolateral medullary depressor area of the rat. American journal of physiology. Heart and circulatory physiology, 2014, Volume: 306, Issue:3 Topics: Adrenergic alpha-1 Receptor Agonists; Angiotensin II; Angiotensinogen; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Captopril; Heart Rate; Losartan; Male; Medulla Oblongata; Nitroprusside; Peptide Fragments; Phenylephrine; Rats; Rats, Wistar; Vasomotor System	2014
Angiotensin II evokes angiogenic signals within skeletal muscle through co-ordinated effects on skeletal myocytes and endothelial cells. PloS one, 2014, Volume: 9, Issue:1 Topics: Angiotensin II; Angiotensinogen; Animals; Cell Line; Endothelial Cells; Extracellular Matrix; Losartan; Male; Matrix Metalloproteinase 2; Mice; Mice, Knockout; Microvessels; Muscle Fibers, Skeletal; Muscle, Skeletal; Neovascularization, Physiologic; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Signal Transduction; Vascular Endothelial Growth Factor A	2014
Losartan attenuates microvascular permeability in mechanical ventilator-induced lung injury in diabetic mice. Molecular biology reports, 2014, Volume: 41, Issue:2 Topics: Angiotensinogen; Animals; Capillary Permeability; Diabetes Mellitus; Losartan; Mice; Mice, Inbred NOD; Ventilator-Induced Lung Injury	2014
Involvement of the brain renin-angiotensin system (RAS) in the neuroadaptive responses induced by amphetamine in a two-injection protocol. Behavioural brain research, 2014, Oct-01, Volume: 272 Topics: Amphetamine; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Brain; Central Nervous System Stimulants; Losartan; Male; Motor Activity; Random Allocation; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; RNA, Messenger	2014
Up-regulation of intrarenal renin-agiotensin system contributes to renal damage in high-salt induced hypertension rats. Kidney & blood pressure research, 2014, Volume: 39, Issue:6 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Diet; Hypertension, Renal; Kidney; Losartan; Male; Proteinuria; Rats; Rats, Wistar; Renin; Renin-Angiotensin System; RNA, Messenger; Sodium Chloride, Dietary; Up-Regulation	2014
The role of KCa3.1 channels in cardiac fibrosis induced by pressure overload in rats. Pflugers Archiv : European journal of physiology, 2015, Volume: 467, Issue:11 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Aorta, Abdominal; Blood Pressure; Cardiomegaly; Cytokines; Fibrosis; Hydroxyproline; Losartan; Male; Myocardium; Potassium Channel Blockers; Pyrazoles; Rats; Rats, Sprague-Dawley; Renin; Shaw Potassium Channels	2015
A novel role for miR-133a in centrally mediated activation of the renin-angiotensin system in congestive heart failure. American journal of physiology. Heart and circulatory physiology, 2017, May-01, Volume: 312, Issue:5 Topics: 3' Untranslated Regions; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Cell Line, Tumor; Heart Failure; Kidney; Losartan; Male; MicroRNAs; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System	2017
Role of the Renin Angiotensin System in Blood Pressure Allostasis-induced by Severe Food Restriction in Female Fischer rats. Scientific reports, 2018, 07-09, Volume: 8, Issue:1 Topics: Aldosterone; Allostasis; Angiotensinogen; Angiotensins; Animals; Blood Pressure; Diet; Female; Losartan; Mesenteric Veins; Peptidyl-Dipeptidase A; Phenylephrine; Rats; Rats, Inbred F344; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System	2018
Losartan prevents the elevation of blood pressure in adipose-PRR deficient female mice while elevated circulating sPRR activates the renin-angiotensin system. American journal of physiology. Heart and circulatory physiology, 2019, 03-01, Volume: 316, Issue:3 Topics: Adipose Tissue; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Antihypertensive Agents; Blood Pressure; Female; Kidney; Liver; Losartan; Mice; Mice, Inbred C57BL; Prorenin Receptor; Receptors, Cell Surface; Renin-Angiotensin System; Vasopressins	2019
Effects of the novel nonsteroidal mineralocorticoid receptor blocker, esaxerenone (CS-3150), on blood pressure and urinary angiotensinogen in low-renin Dahl salt-sensitive hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension, 2019, Volume: 42, Issue:6 Topics: Albuminuria; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Antihypertensive Agents; Blood Pressure; Hypertension; Kidney Function Tests; Losartan; Male; Mineralocorticoid Receptor Antagonists; Pyrroles; Rats; Rats, Inbred Dahl; Renin; Sodium Chloride, Dietary; Sulfones	2019
Losartan and isoproterenol promote alterations in the local renin-angiotensin system of rat salivary glands. PloS one, 2019, Volume: 14, Issue:5 Topics: Adrenergic beta-Agonists; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensinogen; Animals; Immunohistochemistry; Isoproterenol; Losartan; Male; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System; Saliva; Salivary Glands; Serine Endopeptidases	2019
Renoprotective Effects of Small Interfering RNA Targeting Liver Angiotensinogen in Experimental Chronic Kidney Disease. Hypertension (Dallas, Tex. : 1979), 2021, 05-05, Volume: 77, Issue:5 Topics: Angiotensin II; Angiotensinogen; Animals; Antihypertensive Agents; Arterial Pressure; Captopril; Disease Models, Animal; Kidney; Liver; Losartan; Rats; Renal Insufficiency, Chronic; Renin-Angiotensin System; RNA, Small Interfering	2021
Vitamin D suppresses bleomycin-induced pulmonary fibrosis by targeting the local renin-angiotensin system in the lung. Scientific reports, 2021, 08-16, Volume: 11, Issue:1 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Bleomycin; Disease Models, Animal; Ergocalciferols; Losartan; Lung; Mice; Mice, Inbred C57BL; Mice, Knockout; Pulmonary Fibrosis; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System; Transforming Growth Factor beta; Vitamin D	2021
Inhibition of the Renin-Angiotensin System Fails to Suppress β-Aminopropionitrile-Induced Thoracic Aortopathy in Mice-Brief Report. Arteriosclerosis, thrombosis, and vascular biology, 2022, Volume: 42, Issue:10 Topics: Aminopropionitrile; Angiotensin II; Angiotensinogen; Animals; Aortic Aneurysm, Thoracic; Aortic Rupture; Dilatation, Pathologic; Disease Models, Animal; Irbesartan; Losartan; Lysine; Male; Mice; Mice, Inbred C57BL; Protein-Lysine 6-Oxidase; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System	2022
LRP1 protects against excessive superior mesenteric artery remodeling by modulating angiotensin II-mediated signaling. JCI insight, 2023, Jan-24, Volume: 8, Issue:2 Topics: Angiotensin II; Angiotensinogen; Animals; Female; Losartan; Low Density Lipoprotein Receptor-Related Protein-1; Male; Mesenteric Artery, Superior; Mice; Signal Transduction	2023