losartan has been researched along with angiotensin ii in 2423 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.04) | 18.7374 |
| 1990's | 1155 (47.67) | 18.2507 |
| 2000's | 825 (34.05) | 29.6817 |
| 2010's | 381 (15.72) | 24.3611 |
| 2020's | 61 (2.52) | 2.80 |
| Authors | Studies |
|---|---|
| Gogoll, A; Hallberg, A; Karlén, A; Lai, Z; Lindeberg, G; Lindman, S; Nilsson, A; Nyberg, F; Schmidt, B; Sohtell, M; Synnergren, B; Thörnwall, M; Tong, W; Welch, CJ; Westerlund, C | 1 |
| Gogoll, A; Hallberg, A; Johannesson, P; Karlén, A; Lindeberg, G; Nyberg, F; Synnergren, B; Tong, W | 1 |
| Giatas, N; Grdadolnik, SG; Iliodromitis, E; Keivish, T; Kremastinos, D; Matsoukas, J; Mavromoustakos, T; Mutule, I; Polevaya, L; Roumelioti, P; Vlahakos, D; Zoga, A; Zoumpoulakis, P | 1 |
| Anzini, M; Cappelli, A; De Benedetti, PG; Ferrari, F; Gallelli, A; Giorgi, G; Makovec, F; Mennuni, L; Menziani, MC; Pericot Mohr Gl, Gl; Rizzo, M; Vomero, S | 1 |
| Erdélyi, M; Frändberg, PA; Hallberg, A; Johannesson, P; Karlén, A; Lindeberg, G; Nyberg, F | 1 |
| Anzini, M; Cappelli, A; Caselli, G; Ferrari, F; Gallelli, A; Giordani, A; Giorgi, G; Giuliani, G; Makovec, F; Mennuni, L; Mohr, Gl; Nannicini, C; Peris, W; Valenti, S; Vomero, S | 1 |
| Alajarín, R; Alvarez-Builla, J; Díez-Marqués, ML; García, G; Griera, M; Rodríguez-Puyol, D; Rodríguez-Puyol, M; Sánchez-Alonso, P; Serrano, I; Vaquero, JJ | 2 |
| Åqvist, J; Gutiérrez-de-Terán, H; Hallberg, A; Sallander, J; Wallinder, C | 1 |
| Bernhardt, G; Biselli, S; Buschauer, A; Cabrele, C; Einsiedel, J; Gmeiner, P; Hübner, H; Keller, M; Kuhn, KK; Mollereau, C; Svobodová, J; Vanderheyden, PM; Wifling, D | 1 |
| Altieri, P; De Mello, W | 1 |
| Cleutjens, JP; Daemen, MJ; Schoemaker, RG; Smits, JF; van Krimpen, C | 1 |
| Carini, DJ; Chiu, AT; Duncia, JV; Johnson, AL; Timmermans, PB; Wells, GJ; Wexler, RR; Wong, PC | 1 |
| Brunner, HR; Christen, Y; Lee, RJ; Munafo, A; Nussberger, J; Waeber, B | 1 |
| De León, H; Garcia, R | 1 |
| Cote, TE; Crawford, KW; Frey, EA | 1 |
| Fregly, MJ; Rowland, NE | 5 |
| Balla, T; Csordás, G; Enyedi, P; Hajnóczky, G; Hunyady, L; Kalapos, MP; Spät, A | 1 |
| Franco-Saenz, R; Mulrow, PJ; Yamaguchi, T | 1 |
| Cassis, LA; Dwoskin, LP; Jewell, AL | 1 |
| Bird, IM; Magness, RR; Mason, JI; Rainey, WE | 1 |
| Chaki, S; Inagami, T | 1 |
| Li, T; Zimmerman, BG | 1 |
| Camargo, MJ; Campbell, WG; Laragh, JH; Mueller, FB; Sealey, JE; Timmermans, PB; von Lutterotti, N | 1 |
| Achard, JM; Gardin, JP; Houillier, P; Lazar, G; Paillard, M; Poggioli, J | 1 |
| Beierwaltes, WH; Carretero, OA; Sigmon, DH | 1 |
| Carmines, PK; Inscho, EW; Navar, LG; Ohishi, K | 1 |
| Ambühl, P; Felix, D; Ferrario, CM; Imboden, H; Khosla, MC | 1 |
| Hanson, AS; Linas, SL; Marzec, R; Schelling, JR | 1 |
| Lever, AF; MacFadyen, RJ; Reid, JL; Tree, M | 2 |
| Boswell, F; Dornan, ES; Kelly, M; Lyall, F; McQueen, J | 1 |
| Aguilera, G | 1 |
| Kuramochi, M | 1 |
| Carr, RD; Fraser-Rae, L; Hallam, C; Kaiser, FC; Palmer, GC; Wallace, AV | 1 |
| Ambroz, C; Catt, KJ | 1 |
| Fukuchi, S; Hashimoto, S; Mizuno, K; Niimura, S; Ohtsuki, M; Sanada, H; Tani, M; Watanabe, H | 1 |
| Bobik, A; Dilley, RJ; Oddie, CJ | 1 |
| Black, JW; Liu, YJ; Shankley, NP; Welsh, NJ | 1 |
| Fujimoto, M; Itazaki, K; Mihara, S; Shigeri, Y | 1 |
| Fukuchi, S; Gomibuchi, T; Haga, H; Mizuno, K; Niimura, S; Sanada, H; Tani, M | 1 |
| Bui, JD; Kimura, B; Phillips, MI | 1 |
| Akabane, S; Imanishi, M; Kawamura, M; Kuramochi, M; Matsushima, Y; Omae, T | 1 |
| Andries, M; Denef, C; Robberecht, W | 2 |
| Damon, TH; Douglas, JG; Ernsberger, P; Zhou, J | 1 |
| Chang, RS; Chiu, AT; Leung, KH; Lotti, VJ; Roscoe, WA; Smith, RD; Timmermans, PB | 1 |
| Beresford, MJ; Fitzsimons, JT | 1 |
| Abdelrahman, A; Pang, CC | 1 |
| Christ, DD; Timmermans, PB; Wong, PC | 1 |
| Appenheimer, M; Düsing, R; Görg, A; Ko, Y; Sachinidis, A; Vetter, H; Wieczorek, AJ | 1 |
| Brooks, DP; DePalma, PD; Ruffolo, RR | 1 |
| Brune, M; Buckner, S; De, B; DeBernardis, JF; Hancock, A; Kerkman, DJ; Lee, J; Warner, R; Winn, M; Zydowsky, TM | 1 |
| Chiu, AT; McCall, DE; Roscoe, WA | 1 |
| Janiak, P; Pillon, A; Prost, JF; Vilaine, JP | 1 |
| Chen, SJ; Jin, H; Oparil, S; Wyss, JM; Yang, RH | 1 |
| Harris, PJ; Skinner, SL; Thomas, D; Zhuo, J | 1 |
| Barnes, JC; Clark, KL; Dowle, MD; Drew, GM; Marshall, FH; Michel, A; Middlemiss, D; Robertson, MJ; Ross, BC; Scopes, D | 1 |
| Egi, Y; Matsumura, Y; Morimoto, S; Suzuki, Y | 1 |
| Ahmed, SZ; Atwal, KS; Bird, JE; Delaney, CL; Dickinson, KE; Ferrara, FN; Hedberg, A; Miller, AV; Moreland, S; O'Reilly, BC | 1 |
| Garcia, R; Gauquelin, G | 1 |
| Bennett, T; Gardiner, SM; Kemp, PA; Widdop, RE | 3 |
| Hood, JS; Kadowitz, PJ; Kaye, AD; McMahon, TJ; Minkes, RK; Nossaman, BD | 1 |
| Phillips, MI; Renaud, LP; Yang, CR | 1 |
| Brunner, H; Nussberger, J; Waeber, B | 1 |
| Brooks, DP; Edwards, RM; Gellai, M; Jugus, J; Ohlstein, EH; Ruffolo, RR; Sulpizio, A; Vickery, L; Weinstock, J | 1 |
| Kang, J; Posner, P; Sumners, C | 1 |
| Gonzales, N; Hornsby, PJ; Nadler, J; Natarajan, R | 1 |
| Bogdal, Y; Bottari, SP; Deschepper, CF; Obermüller, N; Zahs, KR | 1 |
| Johnson, AK; Kirby, RF; Thunhorst, RL | 1 |
| García-Sáinz, JA; González-Espinosa, C | 1 |
| Hogarty, DC; Phillips, MI; Puig, V; Speakman, EA | 1 |
| Lafayette, RA; Mayer, G; Meyer, TW; Park, SK | 1 |
| Aarhus, LL; Burnett, JC; Chan, DP; Heublein, DM; Sandok, EK | 1 |
| Bjork, FA; Hodges, JC; Keiser, JA; Taylor, DG | 1 |
| Cassis, LA; Fitz, R; Gillespie, MN; Painter, DJ; Rippetoe, PE; Soltis, EE | 1 |
| Carretero, OA; Farhy, RD; Ho, KL; Scicli, AG | 2 |
| Baker, KM; Dostal, DE | 1 |
| Grady, EF; Griffin, CA; Kalinyak, JE; Schambelan, M; Sechi, LA | 2 |
| Inagami, T; Iwai, N | 1 |
| Aiyar, N; Edwards, RM; Hill, DT; Keenan, RM; Stack, EJ; Weidley, EF; Weinstock, J | 1 |
| Blantz, RC; De Nicola, L; Gabbai, FB | 1 |
| Dunne, JF; Melching, G; Momiyama, M; Ransom, JT; Sharif, NA | 1 |
| Jin, H; Oparil, S; Wyss, JM; Yang, RH | 1 |
| Boulay, G; Escher, E; Guillemette, G; Luong, TT; Servant, G | 1 |
| Allen, AM; Mendelsohn, FA; Paxinos, G; Song, K | 1 |
| Rowe, BP; Saylor, DL; Speth, RC | 1 |
| Biollaz, J; Borland, RM; Brunner, HR; Christen, Y; Lee, RJ; Munafo, A; Nussberger, J; Shum, LY; Waeber, B | 1 |
| Abe, K; Hagino, T; Tsunoda, K; Yoshinaga, K | 1 |
| DePasquale, MJ; Fossa, AA; Holt, WF; Mangiapane, ML | 1 |
| Blantz, RC; De Nicola, L; Gabbai, FB; Keiser, JA | 1 |
| Fukuchi, S; Haga, H; Hashimoto, S; Mizuno, K; Niimura, S; Ohtsuki, M; Sanada, H; Tani, M; Watanabe, H | 1 |
| Furtek, CI; Lo, MW | 1 |
| Blaine, EH; Blehm, DJ; Corpus, VM; Huang, HC; Manning, RE; McMahon, EG; Olins, GM; Palomo, MA; Reitz, DB; Schuh, JR | 1 |
| Chang, RS; Lotti, VJ; Scott, AL; Siegl, PK | 1 |
| Entzeroth, M; Mauz, AB; Van Meel, JC; Wienen, W | 1 |
| Banks, RJ; Dourish, CT; Duggan, JA | 1 |
| Carini, DJ; Chiu, AT; Duncia, JV; Johnson, AL; Price, WA; Timmermans, PB; Wexler, RR; Wong, PC | 7 |
| Chakravarty, PK; Chang, RS; Clineschmidt, BV; Greenlee, WJ; Lotti, VJ; Mantlo, NB; Patchett, AA; Siegl, PK | 1 |
| Chakravarty, PK; Chang, RS; Greenlee, WJ; Lotti, VJ; Mantlo, NB; Ondeyka, DL; Patchett, AA; Siegl, PK; Sweet, CS | 1 |
| Barnes, JC; Hawcock, AB; Michel, AD | 1 |
| Crews, FT; Gyurko, R; Kimura, B; Kurian, P; Phillips, MI | 1 |
| Minamisawa, K; Shionoiri, H; Sugimoto, K; Takasaki, I | 1 |
| Christ, DD; Duncia, JV; Pierce, SK; Reilly, TM; Timmermans, PB | 1 |
| Carretero, O; Fenoy, FJ; Roman, RJ; Scicli, G | 1 |
| Saavedra, JM; Strömberg, C; Tsutsumi, K; Viswanathan, M | 2 |
| Herblin, WF; Tam, SW; Timmermans, PB; Wong, PC | 1 |
| Bunting, PB; Cartwright, ME; Frank, JD; Gibson, RE; Schorn, TW; Siegl, PK; Thorpe, HH | 1 |
| Balla, T; Baukal, AJ; Catt, KJ; Eng, S | 1 |
| Byrd, EW; Carr, BR; Rainey, WE; Sinnokrot, RA | 1 |
| Cassis, LA; Dwoskin, LP | 2 |
| D'Orléans-Juste, P; Nantel, F; Regoli, D; Rhaleb, NE; Rouissi, N | 1 |
| Bühlmayer, P; Criscione, L; de Gasparo, M; Herold, P; Kamber, B; Ostermayer, F; Thomann, H; Whitebread, S | 1 |
| Mah, SC; Schnell, C; Wood, JM | 1 |
| Rampersaud, A; Steinberg, MI; Wiest, SA; Zimmerman, K | 1 |
| Baker, KM; Beinlich, CJ; Morgan, HE; White, GJ | 1 |
| Harris, PJ; Mendelsohn, FA; Nobes, MS; Yamada, H | 1 |
| Jackson, EK | 1 |
| Chappell, MC; Diz, DI; Ferrario, CM; Jaiswal, N; Khosla, MC | 1 |
| Jackson, EK; Pong, AS; Tofovic, SP | 1 |
| Bean, JS; Brown, RF; Kauffman, RF; Steinberg, MI; Zimmerman, KM | 1 |
| Duncia, JV; Hart, SD; Timmermans, PB; Wong, PC | 1 |
| Prescott, MF; Reidy, MA; Webb, RL | 1 |
| Barber, PC; Barnes, JM; Barnes, NM | 1 |
| Carter, MR; Cook, VI; Grove, KL; Harding, JW; McMenamin, KM; Speth, RC | 1 |
| Bottari, SP; Culman, J; de Gasparo, M; Gohlke, P; Obermüller, N; Unger, T | 1 |
| Mendelsohn, FA; Song, KF; Zhuo, JL | 1 |
| Dupont, M; Jover, B; Mimran, A; Nafrialdi, E | 1 |
| Düsing, R; Görg, A; Ko, Y; Sachinidis, A; Vetter, H; Wieczorek, AJ | 1 |
| Baumgartner, HR; Clozel, JP; Hefti, F; Müller, RK; Osterrieder, W; Powell, JS | 1 |
| Henning, R; Linz, W; Schölkens, BA | 1 |
| Chiu, AT; McCall, DE; Roscoe, WA; Timmermans, PB | 1 |
| Hajj-ali, AF; Zimmerman, BG | 1 |
| Goldfarb, S; Neilson, EG; Wolf, G; Ziyadeh, FN | 1 |
| Carini, DJ; Chiu, AT; Duncia, JV; Johnson, AL; McCall, DE; Price, WA; Timmermans, PB; Wexler, RR; Wong, PC; Yoo, SE | 2 |
| Epstein, M; Forster, H; Hayashi, K; Loutzenhiser, R; Takenaka, T | 1 |
| Cogan, MG; Liu, FY; Timmermans, PB; Wong, PC; Xie, MH | 2 |
| Daugherty, S; Fonken, SJ; Goldman, S; Lee, RW; Morkin, E; Raya, TE; Timmermans, PB; Wong, PC | 1 |
| Brunner, HR; Christen, Y; Lee, RJ; Nussberger, J; Timmermans, PB; Waeber, B | 1 |
| Gackenheimer, SL; Gehlert, DR; Schober, DA | 2 |
| Saavedra, JM; Tsutsumi, K | 4 |
| Bennett, T; Compton, AM; Foulkes, R; Gardiner, SM; Hughes, B; Kemp, PA | 1 |
| Raizada, MK; Sumners, C; Tang, W; Zelezna, B | 1 |
| Batin, P; Bennett, T; Compton, AM; Gardiner, SM; Kemp, PA | 1 |
| Baum, HP; Bunkenburg, B; Cumin, F; Schnell, C; Wood, JM | 1 |
| Bühlmayer, P; Criscione, L; de Gasparo, M; Fuhrer, W; Furet, P; Stutz, S; Whitebread, S | 1 |
| Carini, DJ; Chiu, AT; Duncia, JV; Johnson, AL; Price, WA; Timmermans, PB; Wells, GJ; Wexler, RR; Wong, PC | 1 |
| Cogan, MG; Liu, FY; Timmermans, PB; Wong, PC | 1 |
| Blankley, CJ; Chucholowski, A; Connolly, CJ; Himmelsbach, RJ; Hodges, JC; Klutchko, SR; Neergaard, SJ; Quin, J; Sebastian, A; Van Nieuwenhze, MS | 1 |
| Barnes, NM; Costall, B; Kelly, ME; Murphy, DA; Naylor, RJ | 1 |
| Batin, P; Bennett, T; Compton, AM; Gardiner, SM | 1 |
| Higuchi, K; Inagami, T; Murakami, T; Nakajo, S | 1 |
| Borland, RM; Brunner, HR; Christen, Y; Lee, RJ; Maggon, K; Nussberger, J; Porchet, M; Shum, L; Timmermans, PB; Waeber, B | 1 |
| Bauer, PH; Chiu, AT; Garrison, JC | 1 |
| Diz, DI; Ferrario, CM; Jaiswal, N; Khosla, MC; Tallant, EA | 2 |
| Hart, SD; Timmermans, PB; Wong, PC | 1 |
| Diz, DI; Ferrario, CM; Khosla, MC; Tallant, EA | 1 |
| Grove, KL; Rowe, BP; Saylor, DL; Speth, RC | 2 |
| Chiu, AT; Leung, KH; Smith, RD; Timmermans, BM | 1 |
| Brunner, HR; Burnier, M; Centeno, G; Grouzmann, E; Waeber, B; Walker, P | 1 |
| Timmermans, PB; Wong, PC | 1 |
| Pfeilschifter, J | 1 |
| García-Sáinz, JA; Macías-Silva, M | 1 |
| Kim, KH; Speth, RC | 1 |
| Ardecky, RJ; Chiu, AT; Hart, SD; Smith, RD; Timmermans, PB; Wong, PC; Zaspel, AM | 1 |
| Aldrich, PE; Chiu, AT; McCall, DE; Timmermans, PB | 1 |
| Ferrario, CM; Khosla, MC; Trachte, GJ | 1 |
| Gackenheimer, SL; Gehlert, DR; Lin, HS; Reel, JK; Steinberg, MI | 1 |
| Reilly, TM; Timmermans, PB; Wong, PC | 1 |
| Alburges, ME; Herblin, WF; Hunt, M; Wamsley, JK | 1 |
| Chang, RS; Lotti, VJ | 1 |
| Bruns, RF; Dudley, DT; Hodges, JC; Klinkefus, BA; Lu, GH; Major, TC; Panek, RL; Weishaar, RE | 1 |
| de Gasparo, M; Kamber, B; Mele, M; Whitebread, S | 1 |
| Campbell, AM; Davidson, AO; Devlin, AM; Dominiczak, AF; Gordon, JF; Morton, JJ; Reid, JL | 1 |
| Andrews, CW; Cowan, CL; Norman, MH; Smith, HD; Steffen, RP; Tang, FL | 1 |
| Baker, KM; Conrad, KM; Dostal, DE; Schorb, W; Singer, HA | 1 |
| Lemmer, B; Schnecko, A; Witte, K | 1 |
| Campbell, DJ; Kladis, A; Valentijn, AJ | 1 |
| Alexander, RW; Clark, M; Griendling, KK; Lassègue, B; Murphy, TJ; Nickenig, G | 1 |
| Chen, C; Lokhandwala, MF | 1 |
| Kunert-Radek, J; Mucha, S; Pawlikowski, M; Pisarek, H; Sepien, H; Stawowy, A | 1 |
| Bonigut, S; Stebbins, CL | 1 |
| Ishiye, M; Nakashima, M; Uematsu, T; Umemura, K | 2 |
| Ciccocioppo, R; Cirillo, R; Massi, M; Polidori, C; Pompei, P | 2 |
| Cachofeiro, V; Lahera, V; Maeso, R; Navarro-Cid, J; Perez-Vizcaino, F; Ruilope, LM; Tamargo, J | 1 |
| Milton, AE; New, AR; Tisher, CC; Weiner, ID | 1 |
| Cockcroft, JR; Goldberg, MR; Ritter, JM; Sciberras, DG | 2 |
| Frewin, DB; Head, RJ; Jonsson, JR; Smid, SD | 1 |
| Bardhan, S; Inagami, T; Kambayashi, Y; Shirai, H; Takahasi, K | 1 |
| Arnet, U; Lüscher, TF; Siebenmann, R; Turina, M; von Segesser, L; Yang, Z | 1 |
| Berkovic, SF; Jenkins, TA; Mendelsohn, FA | 1 |
| Henegar, JR; Janicki, JS; Kabour, A | 1 |
| Hille, B; Shapiro, MS; Wollmuth, LP | 1 |
| Jover, B; Mimran, A; Nafrialdi, N | 1 |
| Pfaffendorf, M; van Zwieten, PA; Zhang, J | 3 |
| Abassi, ZA; Cuda, G; Golomb, E; Keiser, HR; Panchal, VR; Stylianou, M; Trachewsky, D | 1 |
| Baker, KM; Bhat, GJ; Conrad, KM; Thekkumkara, TJ; Thomas, WG | 1 |
| Boyle, TP; Graham, RM; Husain, A; Karnik, SS; Kinoshita, A; Noda, K; Saad, Y | 1 |
| Giasson, E; Meloche, S | 1 |
| Cano, C; Malik, KU; Slavik, KJ | 1 |
| Dean, RH; Ferrario, CM; Fuller, SB; Nakamoto, H; Robaczewski, DL; Winicov, E | 1 |
| Brecher, P; Chobanian, AV; Crawford, DC; Farivar, RS | 1 |
| Chrétien, L; Couture, R; Picard, P | 1 |
| Madsen, KM; Tojo, A; Wilcox, CS | 1 |
| Hartman, JC | 1 |
| Baker, KM; Dostal, DE; Lin, C; Thekkumkara, TJ | 1 |
| Clayton, RA; McGrath, JC; Nally, JE; Thomson, NC; Wakelam, MJ | 1 |
| Lambert, C; Massillon, Y; Meloche, S | 1 |
| Kunihara, M; Kushida, H; Morita, O | 1 |
| Auch-Schwelk, W; Duske, E; Fleck, E; Hess, B; Hildebrandt, AG; Klein, U; Regitz-Zagrosek, V; Steffen, C | 1 |
| Hanley, K; Iyer, SN; Katovich, MJ; Strubbe, G; Wright, BE | 1 |
| Baboolal, K; Meyer, TW | 2 |
| Bao, G; Culman, J; Lebrun, CJ; Möllenhoff, E; Unger, T | 1 |
| Ashton, WT; Chang, LL; Flanagan, K; Gabel, RA; Greenlee, WJ; Kivlighn, SD; Schaffer, LW; Schorn, TW; Siegl, PK; Zingaro, GJ | 1 |
| Ichihara, A; Matsumoto, A; Murakami, M; Naitoh, M; Saruta, T; Suzuki, H | 1 |
| Cazaubon, C; Chatelain, P; Christophe, B; Libon, R; Manning, A; Nisato, D | 1 |
| Smith, RD | 1 |
| Bailey, RR; Gilchrist, NL; Nicholls, MG; Shand, BI | 1 |
| Bauer, IH; Lau-Sieckman, A; Reams, GP; Wu, Z | 1 |
| Durieux, ME | 1 |
| Kim, NJ; Lee, SH; Shin, YA; Yoo, SE | 1 |
| Appay, MD; Bariety, J; Heudes, D; Hinglais, N; Michel, JB; Nicoletti, A; Philippe, M; Sassy-Prigent, C | 1 |
| Goldberg, AI; Pratt, JH; Soffer, BA; Sweet, CS; Wiens, B; Wright, JT | 1 |
| Chen, L; Gopalakrishnan, V; McNeill, JR; Wilson, TW | 1 |
| Bornkessel, B | 1 |
| Brunner, HR; Burnier, M; Nussberger, J; Pechère-Bertschi, A; Waeber, B | 1 |
| Chevalier, RL; Chung, KH; Gomez, RA | 1 |
| el Ghissassi, M; Nicolaïdis, S; Thornton, SN | 1 |
| Ahn, DK; Kim, HJ; Lee, WJ; Park, JS; Park, YY; Yang, EK | 2 |
| Caputo, L; Lévy, BI; Tedgui, A | 1 |
| Hasegawa, S; Imai, S; Kanda, T; Kobayashi, I; Ma, H; Matsuzaki, S; Nakano, M; Suzuki, T | 1 |
| Adamiak, D; Kregel, KC; Mott, A; Redlich, T; Stauss, HM; Unger, T; Zhu, YC | 1 |
| Caussade, F; Cazes, M; Cloarec, A; Delchambre, C; Versigny, A; Virone-Oddos, A | 1 |
| Aubert, JF; Brunner, HR; Niederberger, M; Nussberger, J; Waeber, B | 1 |
| Tabrizchi, R | 1 |
| Knox, FG; Peng, Y | 1 |
| Itskovitz, HD | 1 |
| Guthrie, GP | 1 |
| Aguilera, G; Burns, RC; Cahill, PA; Sitzmann, JV; Wu, Y | 1 |
| Ahmed, A; Barnes, NM; Gregory, J; Li, XF; Newton, JR; Rollason, T; Shams, M | 1 |
| Lark, LA; Wappel, SM; Weyhenmeyer, JA | 1 |
| Fitzgibbon, WR; Hutchison, FN; Imamura, A; Lacy, ER; Mackenzie, HS; Ploth, DW | 1 |
| Hamann, M; Hegyi, I; Kaissling, B; Kurtz, A; Schricker, K | 1 |
| Baker, KM; Dostal, DE; Du, J; Motel, TJ; Thekkumkara, TJ; Thomas, WG | 1 |
| Baldi, E; Catalioto, RM; Cioni, A; Finetti, G; Maggi, M; Mancina, R; Renzetti, AR; Serio, M | 1 |
| Beyer, C; Höhle, S; Nagy, E; Rohmeiss, P; Strauch, M; Tschöpe, C; Unger, T | 1 |
| Christ, DD | 1 |
| Hamakubo, T; Inagami, T; Morishima, I; Nakagomi, Y; Ohyama, K; Sano, T; Yamano, Y | 1 |
| Binkley, PF; Brown, DM; Cody, RJ; Haas, GJ | 1 |
| de Jong, PE; de Zeeuw, D; Gansevoort, RT | 2 |
| Lacourcière, Y | 1 |
| Biagi, BA; Enyeart, JJ; Mlinar, B | 1 |
| Lie, KI; van Zwieten, PA | 1 |
| Deen, WM; Lafayette, RA; Mayer, G; Meyer, TW; Myers, BD; Oliver, J | 1 |
| Ahima, RS; Kadowitz, PJ; Khosla, MC; Minkes, RK; Osei, SY; Weaver, JP | 1 |
| Doig, JK; Lees, KR; MacFadyen, RJ; Reid, JL; Sweet, CS | 1 |
| Chua, BH; Chua, CC; Diglio, CA; Siu, BB | 1 |
| Berdeaux, A; Giudicelli, JF; Richard, V | 1 |
| el Amrani, AI; Gonzales, MF; Menard, J; Michel, JB | 1 |
| Funder, JW; Provencher, PH; Saltis, J | 1 |
| Casanova, C; de Gasparo, M; Merabet, L | 1 |
| Coghlan, JP; Evered, M; Mathai, M; McKinley, MJ | 1 |
| de Gasparo, M; Levens, NR | 1 |
| McKinley, MJ; Oldfield, BJ | 1 |
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| Cui, H; Liang, H; Lv, J; Wang, H; Wang, M; Wang, S; Ye, F; Zheng, Y; Zhu, Y | 1 |
| Campos, GV; Chianca, D; De Menezes, RCA; De Souza, AMA; Ji, H; Linares, A; Sandberg, K; Speth, RC | 1 |
| Chiu, CZ; Shyu, KG; Wang, BW; Yu, YJ | 1 |
| Liu, R; Xin, LH; Yang, XW | 1 |
| Chen, AD; Chen, Q; Kang, YM; Li, YH; Qiu, Y; Wang, JJ; Ye, C; Zheng, F; Zhu, GQ | 1 |
| Jiang, SJ; Liang, LW; Lu, P; Shi, Z; Sun, YY; Xu, AL | 1 |
| Cicogna, AC; Corrêa, CR; da Silva-Bertani, DCT; de Oliveira, EM; de Souza, SLB; de Tomasi, LC; Fernandes, T; Freire, PP; Mota, GAF; Padovani, CR; Sant'Ana, PG; Vileigas, DF | 1 |
| Bergamaschi, CT; Campos, RR; Milanez, MIO; Nishi, EE; Rocha, AA | 1 |
| de Souza, AMA; Ji, H; Sandberg, K; West, CA; Wu, X | 1 |
| Abraham, MN; Bellomo, R; Bijol, V; Capone, C; Deutschman, CS; Fernandes, TD; Lehman, JR; Leisman, DE; Taylor, MD; Yaipan, O | 1 |
| Dong, J; Gao, M; Li, Y; Liu, Y; Suo, Z; Xu, C | 1 |
| Miao, FA; Xu, JG; Zhang, GH; Zhang, Y | 1 |
| Gao, X; Ge, X; Jin, F; Li, S; Li, Y; Mao, N; Wei, Z; Xu, H; Yang, F; Yang, Y; Zhang, M; Zhang, Y | 1 |
| Costa-Ferreira, W; Crestani, CC; Marchi-Coelho, C; Moreno-Santos, B | 1 |
| Franzén, S; Frithiof, R | 1 |
| Kamkar-Del, Y; Mohebbati, R; Shafei, MN | 1 |
| Bao, H; Chen, L; Han, R; Hu, S; Liu, Z; Qin, W; Shi, J; Tang, Z; Xu, X; Zeng, C; Zhang, M; Zhu, X | 1 |
| Ge, J; Jiang, H; Su, Y; Wang, J; Wu, J; Yu, Y; Zhang, B; Zhang, L; Zou, Y | 1 |
| Akasaka, H; Fujimoto, T; Hongyo, K; Huang, Y; Nakagami, F; Nakajima, T; Nozato, Y; Rakugi, H; Sugimoto, K; Takami, Y; Takeshita, H; Takeya, Y; Wang, C; Wang, Y; Yamamoto, K; Yokoyama, S | 1 |
| Abeyat, H; Behmanesh, MA; Poormoosavi, SM; Sangtarash, E | 1 |
| Bovée, DM; Clahsen-van Groningen, MC; Danser, AHJ; Domenig, O; Foster, D; Garrelds, IM; Hoorn, EJ; Huang, S; Kim, JB; Lu, X; Melton, L; Poglitsch, M; Ren, L; Uijl, E; van Veghel, R; Zlatev, I | 1 |
| Antunes-Rodrigues, J; Belém-Filho, IJA; Brasil, TFS; Corrêa, FMA; Fortaleza, EAT | 1 |
| Du, WY; Gao, H; Han, SL; Lin, J; Sun, XF; Zhang, YJ | 1 |
| Abreu, TP; Barahuna-Filho, PFR; Caruso-Neves, C; Cebotaru, L; Cheng, J; Guggino, WB; Peruchetti, DB; Pinheiro, AAS; Silva-Aguiar, RP; Takiya, CM | 1 |
| Dou, W; Gramolini, A; Kuzmanov, U; Lai, BFL; Lu, RXZ; Radisic, M; Rafatian, N; Smith, JB; Sun, Y; Wang, EY; Wu, Q; Yazbeck, J; Zhang, XO | 1 |
| Hao, Q; Hong, Y; Li, S; Sun, R; Wang, S; Wu, W; Zhang, X; Zheng, H | 1 |
| Alexander, B; Casarini, DE; Hassan, R; Leite, APO; Li, XC; Zheng, X; Zhuo, JL | 1 |
| Appendino, G; Caprioglio, D; García-Martín, A; Garrido-Rodríguez, M; Muñoz, E; Navarrete, C; Prados, ME | 1 |
| Chang, J; Du, J; Ge, X; Li, X; Li, YC; Liu, W; Nie, H; Sun, Y; Wei, X; Xun, Z | 1 |
| Agra, RM; Almengló, C; Álvarez, E; Couselo-Seijas, M; Eiras, S; García-Acuña, JM; González-Juanatey, JR; González-Peteiro, M; Varela-Román, A | 1 |
| Behuliak, M; Hojná, S; Rauchová, H; Řezáčová, L; Valovič, P; Vaněčková, I; Vavřínová, A; Zicha, J | 1 |
| Balachandran, K; Ozkizilcik, A; Patel, S; Sysavanh, F; Tandon, I | 1 |
| Bouvier, M; Costa-Neto, CM; Duarte, DA; Oliveira, EB; Parreiras-E-Silva, LT | 1 |
| Alenina, N; Bader, M; Clahsen-van Groningen, MC; Danser, AHJ; Essers, J; Garrelds, IM; Qadri, F; Ridwan, Y; Roks, AJM; van der Linden, J; van der Pluijm, I; van Thiel, BS; Vermeij, M | 1 |
| Carletti, R; Castoldi, G; di Gioia, CRT; Ippolito, S; Pelucchi, S; Stella, A; Zatti, G; Zerbini, G | 1 |
| Gao, J; Huang, C; Shen, W; Wei, T | 1 |
| Cowley, AW; Kurth, T; Shimada, S; Yang, C | 1 |
| Ali, Y; Dohi, K; Ito, H; Ito, M; Katayama, K; Okamoto, R; Zhe, Y | 1 |
| Andrade, CAF; Coletto-Nunes, G; De Luca, LA; Menani, JV; Oliveira, LM; Pereira, ED; Souza, PPC | 1 |
| Adjaye, J; Bohndorf, M; Erichsen, L; Rahman, MS; Thimm, C; Wruck, W | 1 |
| Byun, JK; Jeong, JH; Kim, DJ; Kim, HC; Ko, SK; Lee, Y; Lei, XG; Nabeshima, T; Nah, SY; Nguyen, BT; Sharma, N; Shin, EJ | 1 |
| Choopani, S; Nematbakhsh, M | 1 |
| Couto, GK; França-Neto, A; Rossoni, LV; Xavier, FE | 1 |
| Costa-Sarmento, G; Muzi-Filho, H; Nossar, LF; Pereira-Acácio, A; Veloso-Santos, JPM; Vieyra, A | 1 |
| Daugherty, A; Franklin, MK; Howatt, DA; Lu, HS; Moorleghen, JJ; Mullick, AE; Ohno-Urabe, S; Sawada, H; Ye, D | 1 |
| Becker, B; Qi, Z; Xu, T; Zhang, R; Zhao, W; Zhou, F | 1 |
| Berto-Junior, C; Guimarães-Nobre, CC; Mendonça-Reis, E; Miranda-Alves, L; Teixeira-Alves, LR | 1 |
| Atmuri, NDP; Bernatchez, P; Cait, J; Ciufolini, MA; Donen, G; Dong, Y; Hughes, M; McNagny, KM; Pechkovsky, D; Sauge, E; Sin, DD; Tam, A; Tehrani, AY; Walker, MJA; White, Z; Yuen, C | 1 |
| Chai, YF; Chen, XS; Gao, YL; Liu, CY; Liu, YC; Meng, XL; Shou, ST; Wang, SH; Wei, W | 1 |
| Chen, W; Han, L; Ji, H; Yu, L; Zhu, H | 1 |
| Abuiessa, SA; El-Gowelli, HM; El-Gowilly, SM; El-Mas, MM; Helmy, MM | 1 |
| Aicher, BO; Au, DT; Daugherty, A; Franklin, MK; Hampton, B; Howatt, DA; Lu, HS; Migliorini, M; Moorleghen, JJ; Mullick, AE; Muratoglu, SC; Ni, F; Sawada, H; Strickland, DK; Ucuzian, AA; Wang, P; Wani, MM; Zhang, JM | 1 |
| Fan, X; Han, Y; Jiao, X; Shen, Y; Su, L; Wang, D; Wang, Z; Zheng, L | 1 |
| Blanco, GA; Canellada, AM; Castro, MS; Macchi, R; Parrado, AC; Rey-Roldán, EB; Salaverry, LS; Sotelo, AD | 1 |
| Kozyreva, TV; Voronova, IP | 1 |
| Danilenko, AV; Platonova, YB; Savilov, SV; Volov, AN; Volov, NA | 1 |
| Chen, L; Ge, F; Guo, J; He, Y; Hu, K; Jia, M; Jiang, L; Jin, J; Li, L; Li, Q; Lv, X; Ma, S; Meng, D; Osto, E; Wang, X; Wei, X; Wu, H; Wu, J; Yang, Z; Zhang, J; Zhi, X | 1 |
| Adjaye, J; Erichsen, L; Thimm, C; Wruck, W | 1 |
| Lang, JA; Schwartz, KS; Stanhewicz, AE | 1 |
117 review(s) available for losartan and angiotensin ii
| Article | Year |
|---|---|
Rationale for the chemical development of angiotensin II receptor antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Drug Design; Humans; Hypertension; Imidazoles; Losartan; Renin-Angiotensin System; Tetrazoles | 1992 |
[Renin-angiotensin system blockade. What can be expected from angiotensin II antagonists?].
Topics: Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Renin-Angiotensin System; Teprotide; Tetrazoles | 1992 |
The discovery of DuP 753, a potent, orally active nonpeptide angiotensin II receptor antagonist.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Binding, Competitive; Biphenyl Compounds; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Imidazoles; Kallikrein-Kinin System; Losartan; Models, Chemical; Rabbits; Rats; Renin-Angiotensin System; Tetrazoles | 1992 |
[Nonpeptide angiotensin II antagonists].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Humans; Imidazoles; Losartan; Tetrazoles | 1992 |
In vitro pharmacology of DuP 753.
Topics: Adrenal Cortex; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Imidazoles; In Vitro Techniques; Losartan; Organ Specificity; Rats; Tetrazoles | 1991 |
In vivo pharmacology of DuP 753.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Hypertension; Imidazoles; Losartan; Rats; Reference Values; Tetrazoles | 1991 |
Angiotensin II receptor antagonists. From discovery to antihypertensive drugs.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Humans; Imidazoles; Losartan; Receptors, Angiotensin; Tetrazoles | 1991 |
Vascular smooth muscle polyploidy in genetic hypertension: the role of angiotensin II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Cell Cycle; Humans; Hypertension; Imidazoles; Losartan; Models, Cardiovascular; Muscle, Smooth, Vascular; Ploidies; Tetrazoles | 1995 |
[Angiotensin II receptor antagonists].
Topics: Amino Acid Sequence; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Hemodynamics; Humans; Hypertension; Imidazoles; Losartan; Molecular Sequence Data; Pyridines; Receptors, Angiotensin; Renin-Angiotensin System; Saralasin; Tetrazoles | 1995 |
Pharmacology of angiotensin II receptors in the kidney.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Humans; Imidazoles; Kidney; Losartan; Oligopeptides; Pyridines; Rats; Receptors, Angiotensin; Species Specificity; Tetrazoles; Tissue Distribution | 1994 |
Losartan in heart failure: preclinical experiences and initial clinical outcomes.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Heart Failure; Hemodynamics; Humans; Imidazoles; Losartan; Rats; Receptors, Angiotensin; Sheep; Tetrazoles | 1994 |
Agonist-antagonist interactions at angiotensin receptors: application of a two-state receptor model.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Computer Simulation; Drug Interactions; Imidazoles; Losartan; Models, Biological; Receptors, Angiotensin; Tachyphylaxis; Tetrazoles | 1994 |
Human angiotensin receptor subtypes.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; DNA, Complementary; Gene Library; Humans; Imidazoles; Losartan; Oligopeptides; Pyridines; Receptors, Angiotensin; Tetrazoles | 1994 |
Angiotensin II antagonists DuP 753 and TCV 116.
Topics: Administration, Oral; Angiotensin II; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Humans; Hypertension; Imidazoles; Losartan; Renin-Angiotensin System; Tetrazoles | 1994 |
The advantages of angiotensin II antagonism.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Enalapril; Hemodynamics; Humans; Imidazoles; Kidney; Losartan; Renin-Angiotensin System; Tetrazoles | 1994 |
New perspectives in angiotensin system control.
Topics: Amino Acid Sequence; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Cardiomegaly; Hemodynamics; Humans; Imidazoles; Losartan; Molecular Sequence Data; Pyridines; Renin-Angiotensin System; Tetrazoles | 1993 |
Clinical experience with angiotensin II receptor antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Pressure; Drug Tolerance; Humans; Hypertension; Imidazoles; Losartan; Renin-Angiotensin System; Tetrazoles | 1993 |
[Non-peptide antagonists to angiotensin II receptors. A review].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Humans; Imidazoles; Losartan; Receptors, Angiotensin; Renin-Angiotensin System; Tetrazoles | 1993 |
Angiotensin II antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Reference Values; Renin-Angiotensin System; Saralasin; Tetrazoles | 1993 |
Angiotensin II receptor blockade: an innovative approach to cardiovascular pharmacotherapy.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cardiovascular Diseases; Heart Failure; Homeostasis; Humans; Hypertension; Imidazoles; Losartan; Receptors, Angiotensin; Renin-Angiotensin System; Saralasin; Tetrazoles | 1993 |
New therapeutic agents in the management of hypertension: angiotensin II-receptor antagonists and renin inhibitors.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Clinical Trials as Topic; Dipeptides; Heart Failure; Humans; Hypertension; Imidazoles; Losartan; Renin; Tetrazoles | 1993 |
Theoretical basis for the use of angiotensin II antagonists in the treatment of heart failure.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Compounds; Cardiac Output, Low; Humans; Imidazoles; Losartan; Tetrazoles | 1993 |
Angiotensin II receptors and angiotensin II receptor antagonists.
Topics: Amino Acid Sequence; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Cloning, Molecular; Hemodynamics; Humans; Hypertension; Imidazoles; Kidney; Losartan; Molecular Sequence Data; Pyridines; Receptors, Angiotensin; Tetrazoles | 1993 |
Angiotensin antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Humans; Hypertension; Imidazoles; Kidney; Losartan; Receptors, Angiotensin; Saralasin; Tetrazoles | 1993 |
Direct selective blockade of the vascular angiotensin II receptors in therapy for hypertension and severe congestive heart failure.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Bradykinin; Heart Failure; Humans; Hypertension; Imidazoles; Losartan; Prostaglandin Antagonists; Receptors, Angiotensin; Tetrazoles | 1996 |
Role of angiotensin II in blood pressure regulation and in the pathophysiology of cardiovascular disorders.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Cardiovascular Diseases; Humans; Hypertension; Imidazoles; Losartan; Rats; Renin-Angiotensin System; Tetrazoles | 1995 |
Discovery of losartan, the first angiotensin II receptor antagonist.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Clinical Trials as Topic; Humans; Hypertension; Imidazoles; Losartan; Structure-Activity Relationship; Tetrazoles | 1995 |
Effect of angiotensin II blockade on cardiac hypertrophy and remodelling: a review.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Humans; Hypertension; Hypertrophy, Left Ventricular; Imidazoles; Losartan; Rats; Renin-Angiotensin System; Tetrazoles | 1995 |
The future role of losartan.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Forecasting; Humans; Hypertension; Imidazoles; Losartan; Renin-Angiotensin System; Tetrazoles | 1995 |
Angiotensin receptors and their antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensins; Antihypertensive Agents; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Receptors, Angiotensin; Signal Transduction; Tetrazoles | 1996 |
Angiotensin II receptor blockers. A new class of antihypertensive drugs.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzothiadiazines; Biphenyl Compounds; Blood Pressure; Clinical Trials as Topic; Diuretics; Enalapril; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Multicenter Studies as Topic; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Sodium Chloride Symporter Inhibitors; Tetrazoles | 1996 |
Angiotensin receptors and their therapeutic implications.
Topics: Amino Acid Sequence; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Cardiovascular Diseases; Gene Expression Regulation; Humans; Imidazoles; Losartan; Molecular Sequence Data; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Renin-Angiotensin System; Structure-Activity Relationship; Tetrazoles; Tissue Distribution | 1996 |
Relationship between the drinking response to angiotensin II and induction of Fos in the brain.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Brain; Catheterization, Central Venous; Catheterization, Peripheral; Drinking; Hypotension; Imidazoles; Losartan; Proto-Oncogene Proteins c-fos; Subfornical Organ; Tetrazoles; Thirst | 1996 |
Pharmacokinetic-pharmacodynamic relationships of three angiotensin II receptor antagonists in normal volunteers.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Humans; Imidazoles; Irbesartan; Losartan; Prodrugs; Reference Values; Tetrazoles | 1996 |
Angiotensin II receptor antagonists: the prototype losartan.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Clinical Trials as Topic; Humans; Imidazoles; Losartan; Renin-Angiotensin System; Tetrazoles | 1996 |
Angiotensin II receptor inhibition. A new therapeutic principle.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Clinical Trials as Topic; Drug Evaluation, Preclinical; Hemodynamics; Humans; Hypertension; Imidazoles; Losartan; Receptors, Angiotensin; Tetrazoles | 1996 |
[Angiotensin-2 receptor blockade--new therapeutic approach to treatment of hypertension].
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Tetrazoles | 1996 |
The diversified pharmacology of angiotensin II-receptor blockade.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Receptors, Angiotensin; Tetrazoles | 1996 |
[Losartan, an angiotensin II receptor blocker: a new trend in cardiovascular chemotherapy].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Cardiovascular Diseases; Cerebrovascular Disorders; Coronary Disease; Heart Failure; Humans; Hypertension; Hypertension, Renovascular; Imidazoles; Kidney Diseases; Losartan; Myocardial Infarction; Rats; Receptors, Angiotensin; Renin-Angiotensin System; Tetrazoles; Time Factors | 1996 |
Pathologic consequences of increased angiotensin II activity.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Renin-Angiotensin System; Tetrazoles | 1996 |
Molecular determinants of peptide and non-peptide binding to the AT1 receptor.
Topics: Amino Acid Sequence; Angiotensin II; Animals; Binding, Competitive; Biphenyl Compounds; Down-Regulation; GTP-Binding Proteins; Humans; Imidazoles; Losartan; Molecular Sequence Data; Phenotype; Point Mutation; Receptors, Angiotensin; Sequence Alignment; Sequence Homology, Amino Acid; Species Specificity; Tetrazoles; Vasoconstrictor Agents | 1996 |
Pharmacokinetic-pharmacodynamic profile of angiotensin II receptor antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Clinical Trials as Topic; Humans; Imidazoles; Losartan; Renin; Tetrazoles; Valine; Valsartan | 1997 |
Losartan: a new antihypertensive drug.
Topics: Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Nursing Assessment; Patient Education as Topic; Tetrazoles | 1997 |
The medicine of the month. Losartan (Cozaar).
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Tetrazoles | 1997 |
Angiotensin II antagonism: a new avenue of hypertension management.
Topics: Aged; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Clinical Trials as Topic; Heart Failure; Humans; Hypertension; Imidazoles; Losartan; Tetrazoles | 1997 |
Regulation of proximal tubule transport by angiotensin II.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biological Transport; Enalaprilat; Homeostasis; Kidney Tubules, Proximal; Losartan; Rats; Receptors, Angiotensin; Renin-Angiotensin System | 1997 |
[AT1 angiotensin receptor inhibition as a new therapeutic possibility].
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Female; Heart Failure; Humans; Hypertension; Losartan; Renin-Angiotensin System | 1997 |
[The advent of a new class of antihypertensive agents: angiotensin II receptor antagonists].
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzothiadiazines; Blood Pressure; Cardiac Output, Low; Controlled Clinical Trials as Topic; Diuretics; Humans; Hypertension; Incidence; Losartan; Patient Compliance; Placebos; Sodium Chloride Symporter Inhibitors | 1997 |
[Current therapy: losartan].
Topics: Angiotensin II; Antihypertensive Agents; Drug Costs; Humans; Hypertension; Losartan; Renin-Angiotensin System | 1997 |
Transduction of antinatriuretic signals in renal proximal tubular cells in cirrhosis: introduction to novel approaches to the treatment of sodium retention.
Topics: Adrenergic Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Humans; Kidney Tubules, Proximal; Liver Cirrhosis; Losartan; Models, Biological; Natriuresis; Norepinephrine; Signal Transduction; Sodium; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase | 1998 |
[Pathophysiological function of angiotensin II AT1 and AT2 receptors and clinical application of AT1 antagonists].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Calcium; Captopril; Cardiovascular System; Clinical Trials as Topic; Heart Failure; Humans; Kidney; Losartan; Protein Kinase C; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Signal Transduction | 1998 |
[Losartan--a nonpeptide antagonist of angiotensin-II receptors in the treatment of heart failure].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cardiovascular Agents; Drug Evaluation, Preclinical; Heart Failure; Humans; Losartan; Randomized Controlled Trials as Topic; Receptors, Angiotensin; Renin-Angiotensin System | 1998 |
The discovery and development of angiotensin II antagonists.
Topics: Angiotensin II; Animals; Humans; Imidazoles; Losartan; Structure-Activity Relationship; Tetrazoles | 1998 |
Tolerability of a modern antihypertensive agent: candesartan cilexetil.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Humans; Losartan; Prodrugs; Randomized Controlled Trials as Topic; Tetrazoles | 1998 |
Angiotensin II receptors.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Endothelium; Humans; Imidazoles; Kidney; Losartan; Peptide Fragments; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles | 1999 |
Mesangial AT1 receptors: expression, signaling, and regulation.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Binding, Competitive; Biphenyl Compounds; Cells, Cultured; Gene Expression Regulation; Glomerular Mesangium; Humans; Losartan; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Signal Transduction; Tetrazoles | 1999 |
Angiotensin II receptor pharmacology and AT1-receptor blockers.
Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles; Thiophenes | 1999 |
The benefits of angiotensin II receptor blockers in patients with renal insufficiency or failure.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Disease Models, Animal; Humans; Hypertension; Losartan; Rats; Renal Insufficiency; Renin-Angiotensin System; Treatment Outcome | 1998 |
Angiotensin-II receptor antagonists: their place in therapy.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Clinical Trials as Topic; Drug Administration Schedule; Drug Interactions; Heart Failure; Humans; Hypertension; Irbesartan; Losartan; Renin-Angiotensin System; Telmisartan; Tetrazoles; Valine; Valsartan | 1999 |
Non-peptide angiotensin type 1 receptor antagonists in the treatment of hypertension.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Humans; Hypertension; Losartan | 1999 |
Angiotensin II receptor antagonists in the treatment of hypertension.
Topics: Algorithms; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Humans; Hypertension; Irbesartan; Losartan; Receptors, Angiotensin; Telmisartan; Tetrazoles; Valine; Valsartan | 1999 |
[Angiotensin II receptor antagonists. Clinically significant differences].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Cardiovascular Diseases; Drug Therapy, Combination; Humans; Losartan; Receptors, Angiotensin; Renin-Angiotensin System | 1999 |
[Antihypertensive advantages of angiotensin II AT1 receptor antagonism].
Topics: Aged; Angiotensin II; Angiotensin Receptor Antagonists; Anti-Arrhythmia Agents; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Clinical Trials as Topic; Heart Diseases; Heart Failure; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan | 1999 |
Angiotensin II type 1 receptor blockade: a new development in cardiovascular pharmacology.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Cardiovascular Diseases; Cardiovascular System; Heart Failure; Humans; Hypertension; Losartan; Receptors, Angiotensin; Renin-Angiotensin System | 1998 |
Is there an advantage to combination therapy with ACE inhibitors and angiotensin II-receptor blockers?
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Captopril; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Hypertension; Losartan | 2000 |
Angiotensin II antagonists for hypertension: are there differences in efficacy?
Topics: Angiotensin II; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Humans; Hypertension; Irbesartan; Losartan; Randomized Controlled Trials as Topic; Tetrazoles; Valine; Valsartan | 2000 |
Angiotensin receptor antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Humans; Hypertension; Irbesartan; Losartan; Telmisartan; Tetrazoles | 2000 |
[Use of angiotensin-II-antagonists in hypertension].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Drug Therapy, Combination; Hypertension; Losartan; Randomized Controlled Trials as Topic; Receptors, Angiotensin; Tetrazoles; Valine; Valsartan | 2000 |
Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure.
Topics: Aminopeptidases; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Arteries; Binding Sites; Blood Pressure; Brain; CD13 Antigens; Dose-Response Relationship, Drug; Glutamyl Aminopeptidase; Hypertension; Hypothalamus; Losartan; Mice; Models, Chemical; Mutagenesis, Site-Directed; Peptides; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Thermolysin; Vasopressins | 2000 |
Angiotensin-(1-7): an update.
Topics: Angiotensin I; Angiotensin II; Animals; Blood Vessels; Central Nervous System; Humans; Kidney; Losartan; Models, Biological; Myocardium; Peptide Fragments; Peptidyl-Dipeptidase A; Protein Binding; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Signal Transduction; Vasoconstriction | 2000 |
Prospective trials of angiotensin receptor blockers: beyond blood pressure control.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Humans; Hypertension; Losartan; Myocardial Infarction; Tetrazoles; Valine; Valsartan | 2000 |
[Angiotensin-II-receptor antagonists for cardiac insufficiency].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Captopril; Dose-Response Relationship, Drug; Drug Therapy, Combination; Heart Failure; Humans; Losartan; Randomized Controlled Trials as Topic; Tetrazoles | 2000 |
Putting the efficacy of candesartan cilexetil into perspective: a review of new comparative data.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cattle; Cerebellum; Circadian Rhythm; Female; Heart; Humans; Hypertension; In Vitro Techniques; Irbesartan; Kinetics; Losartan; Male; Middle Aged; Prodrugs; Rabbits; Randomized Controlled Trials as Topic; Receptors, Angiotensin; Renin; Tetrazoles; Time Factors | 2000 |
Angiotensin II type 1 receptor blockers.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Binding, Competitive; Biphenyl Compounds; Blood Pressure; Drug Design; Humans; Irbesartan; Losartan; Peptidyl-Dipeptidase A; Protein Binding; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin-Angiotensin System; Saralasin; Tetrazoles; Valine; Valsartan | 2001 |
The role of angiotensin receptor blockers in the management of chronic heart failure.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Bradykinin; Chronic Disease; Clinical Trials as Topic; Forecasting; Heart Failure; Humans; Losartan | 2001 |
Expanded role for ARBs in cardiovascular and renal disease? Recent observations have far-reaching implications.
Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Benzoates; Biological Availability; Biphenyl Compounds; Cardiovascular Diseases; Humans; Imidazoles; Irbesartan; Kidney Diseases; Losartan; Metabolic Clearance Rate; Patient Selection; Renin-Angiotensin System; Telmisartan; Tetrazoles; Thiophenes; Treatment Outcome; Valine; Valsartan | 2001 |
Role of transforming growth factor-beta1 in the progression of chronic allograft nephropathy.
Topics: Angiotensin II; Antihypertensive Agents; Biomarkers; Disease Progression; Endothelin-1; Humans; Kidney Transplantation; Losartan; Renin-Angiotensin System; Transforming Growth Factor beta; Transplantation, Homologous | 2001 |
Angiotensin receptor blockers and aldosterone antagonists in chronic heart failure.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Captopril; Heart Failure; Humans; Hypertension; Losartan; Mineralocorticoid Receptor Antagonists; Renin-Angiotensin System; Spironolactone; Tetrazoles; Valine; Valsartan | 2001 |
Angiotensin receptor blockers for chronic heart failure and acute myocardial infarction.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Drug Therapy, Combination; Heart Failure; Humans; Losartan; Models, Cardiovascular; Myocardial Infarction; Randomized Controlled Trials as Topic; Tetrazoles | 2001 |
[Angiotensin II type-1-receptor antagonists from the viewpoint of nephrology].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Bradykinin; Diabetic Nephropathies; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Losartan; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Therapeutic Equivalency | 2001 |
The protective effect of blocking angiotensin in both type I and type II diabetics with nephropathy.
Topics: Aged; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Compounds; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Irbesartan; Losartan; Male; Middle Aged; Primary Prevention; Prognosis; Randomized Controlled Trials as Topic; Risk Assessment; Sensitivity and Specificity; Tetrazoles; Treatment Outcome | 2001 |
Novel mechanisms linking angiotensin II and early atherogenesis.
Topics: Angiotensin II; Animals; Arteriosclerosis; Humans; Losartan; Models, Cardiovascular; Monocytes; Phenotype | 2000 |
[Results from the LIFE study: promising effects of new hypertensive agents].
Topics: Adrenergic beta-Antagonists; Adult; Angiotensin II; Antihypertensive Agents; Atenolol; Humans; Hypertension; Hypertrophy, Left Ventricular; Losartan; Middle Aged; Randomized Controlled Trials as Topic; Treatment Outcome | 2002 |
[Type 2 diabetes and nephropathy--new studies, new treatment strategies?].
Topics: Amlodipine; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Losartan; Randomized Controlled Trials as Topic; Renin-Angiotensin System | 2002 |
Angiotensin and baroreflex control of the circulation.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Baroreflex; Blood Circulation; Blood Pressure; Brain Stem; Kidney; Losartan; Medulla Oblongata; Rabbits; Rats; Receptor, Angiotensin, Type 1; Sympathetic Nervous System | 2002 |
Does the angiotensin II receptor antagonist losartan improve cognitive function?
Topics: Aged; Aged, 80 and over; Aging; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Clinical Trials as Topic; Cognition Disorders; Humans; Hypertension; Losartan | 2002 |
Angiotensin receptor antagonists in patients with nephropathy due to type 2 diabetes.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Hypertension, Renal; Irbesartan; Losartan; Renin-Angiotensin System; Tetrazoles | 2002 |
Losartan in diabetic nephropathy.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dose-Response Relationship, Drug; Humans; Kidney Failure, Chronic; Losartan; Receptor, Angiotensin, Type 1 | 2003 |
Central angiotensin modulation of baroreflex control of renal sympathetic nerve activity in the rat: influence of dietary sodium.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Baroreflex; Benzimidazoles; Bicuculline; Biphenyl Compounds; Blood Pressure; Brain; Cerebral Ventricles; Kidney; Losartan; Medulla Oblongata; Paraventricular Hypothalamic Nucleus; Rats; Renin; Renin-Angiotensin System; Sodium, Dietary; Sympathetic Nervous System; Tetrazoles | 2003 |
[Treatment for diastolic failure].
Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Calcium Channel Blockers; Diastole; Heart Failure; Humans; Losartan; Practice Guidelines as Topic; Receptor, Angiotensin, Type 1; Tetrazoles | 2003 |
Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites.
Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Growth Hormone; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Models, Molecular; Receptor, Angiotensin, Type 1; Tetrazoles; Thiophenes; Thromboxane A2 | 2003 |
Pharmacoeconomic aspects of losartan treatment to delay progression of renal disease in patients with Type 2 diabetes.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Health Care Costs; Humans; Irbesartan; Kidney Failure, Chronic; Losartan; Tetrazoles; Treatment Outcome | 2003 |
[New perspectives of the use of angiotensin II receptor blocker].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Atenolol; Diabetes Mellitus; Humans; Hypertension; Hypertrophy, Left Ventricular; Hyperuricemia; Losartan; Receptors, Angiotensin | 2003 |
Stress and angiotensin II: novel therapeutic opportunities.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Humans; Losartan; Receptor, Angiotensin, Type 1; Stress, Physiological | 2003 |
Losartan and other angiotensin II antagonists for nephropathy in type 2 diabetes mellitus: a review of the clinical trial evidence.
Topics: Albuminuria; Amlodipine; Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Irbesartan; Kidney Failure, Chronic; Losartan; Proteinuria; Tetrazoles | 2003 |
Conformation and bioactivity. Design and discovery of novel antihypertensive drugs.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Drug Design; Humans; Hypertension; Losartan; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Mimicry; Peptides; Structure-Activity Relationship | 2004 |
[Involvement of angiotensin II in pathogenesis of hypertension and target organ damage].
Topics: Angioplasty, Balloon, Coronary; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arteriosclerosis; Cardiomegaly; Clinical Trials as Topic; Coronary Restenosis; Humans; Hypertension; Hypertension, Renal; Insulin Resistance; Losartan; Ramipril; Receptor, Angiotensin, Type 1 | 2004 |
[Hypertension in patients with cardiac hypertrophy].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Diabetes Complications; Diabetes Mellitus; Humans; Hypertension; Hypertrophy, Left Ventricular; Losartan; Randomized Controlled Trials as Topic; Renin-Angiotensin System; Risk Factors | 2004 |
[Organ protection by angiotensin II receptor blockers].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cognition Disorders; Heart Failure; Humans; Hypertension; Kidney Diseases; Losartan; Membrane Proteins; Mineralocorticoid Receptor Antagonists; Proteins; Proteinuria; Randomized Controlled Trials as Topic; Stroke; Tetrazoles | 2004 |
Prevention and treatment of stroke in patients with hypertension.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Anticoagulants; Antihypertensive Agents; Costs and Cost Analysis; Humans; Hypertension; Losartan; Quality of Life; Randomized Controlled Trials as Topic; Risk Factors; Stroke | 2004 |
Treatment of systolic hypertension: spotlight on recent studies with angiotensin II antagonists.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Clinical Trials as Topic; Humans; Hypertension; Losartan; Patient Compliance; Practice Guidelines as Topic; Stroke; Systole | 2005 |
The role of angiotensin antagonism in stroke prevention in patients with hypertension: focus on losartan.
Topics: Angiotensin II; Antihypertensive Agents; Clinical Trials as Topic; Humans; Hypertension; Losartan; Stroke | 2004 |
Stroke prevention with losartan in the context of other antihypertensive drugs.
Topics: Angiotensin II; Antihypertensive Agents; Clinical Trials as Topic; Humans; Losartan; Stroke | 2004 |
[The renin-angiotensin-aldosterone system -- more complex as previously thought].
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Chronic Disease; Chymases; Clinical Trials as Topic; Diabetic Nephropathies; Disease Progression; Drug Therapy, Combination; Humans; Indoles; Kidney Diseases; Kidney Tubules, Proximal; Losartan; Prospective Studies; Receptors, Angiotensin; Renin-Angiotensin System; Risk Factors; Serine Endopeptidases | 2005 |
Angiotensin II antagonists: clinical experience in the treatment of hypertension, prevention of cardiovascular outcomes and renal protection in diabetic nephropathy and proteinuria.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biphenyl Compounds; Cardiovascular System; Diabetic Nephropathies; Humans; Hypertension; Irbesartan; Kidney; Losartan; Proteinuria; Tetrazoles | 2006 |
Ventricular hypertrophy and hypertension: prognostic elements and implications for management.
Topics: Adrenergic Antagonists; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Benzoates; Carbazoles; Carvedilol; Chi-Square Distribution; Cohort Studies; Coronary Disease; Death, Sudden, Cardiac; Diuretics; Drug Therapy, Combination; Echocardiography; Electroencephalography; Enalapril; Female; Follow-Up Studies; Heart Failure; Humans; Hypertension; Hypertrophy, Left Ventricular; Indapamide; Logistic Models; Losartan; Male; Multivariate Analysis; Prognosis; Propanolamines; Prospective Studies; Randomized Controlled Trials as Topic; Risk; Risk Assessment; Risk Factors; Sex Factors; Stroke; Survival Analysis; Telmisartan | 2006 |
[New therapeutic targets for ACE inhibitors and angiotensin receptor blockers].
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Benzoates; Cardiovascular Diseases; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypertension; Losartan; Metabolic Syndrome; Peptidyl-Dipeptidase A; Renin-Angiotensin System; Risk Reduction Behavior; Telmisartan; Treatment Outcome | 2007 |
Pathophysiology of target-organ disease: does angiotensin II remain the key?
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Calcium Channel Blockers; Cardiovascular Diseases; Disease Progression; Humans; Hypertension; Losartan; Myocardial Infarction; Renin; Renin-Angiotensin System; Stroke; Tetrazoles; Treatment Outcome; Valine; Valsartan | 2007 |
The preclinical basis of the therapeutic evaluation of losartan.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Disease Models, Animal; Humans; Hypertension; Losartan; Rats; Rats, Inbred SHR; Renal Insufficiency; Renin-Angiotensin System | 1995 |
Differences in pharmacology and their translation into differences in clinical efficacy--a comparison of the renin angiotensin blocking agents irbesartan and losartan.
Topics: Administration, Oral; Angiotensin II; Antihypertensive Agents; Biological Availability; Biphenyl Compounds; Blood Pressure; Diabetic Nephropathies; Health Care Costs; Humans; Hypertension; Irbesartan; Losartan; Tetrazoles; Treatment Outcome | 2010 |
[Regeneration of perivascular nerve and role of angiotensin receptors].
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Calcitonin Gene-Related Peptide; Humans; Imidazoles; Losartan; Male; Mesenteric Arteries; Nerve Growth Factor; Nerve Regeneration; Neuropeptide Y; Peripheral Nerve Injuries; Peripheral Nerves; Phenol; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 2; Stimulation, Chemical | 2010 |
Role of AT1 receptors in the central control of sympathetic vasomotor function.
Topics: Angiotensin II; Animals; Baroreflex; Brain Stem; Kidney; Losartan; Pressoreceptors; Receptor, Angiotensin, Type 1; Sympathetic Nervous System; Vasomotor System | 1996 |
[Progress of pediatric nephrology].
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Antibodies, Monoclonal, Murine-Derived; Biomarkers; Child; Clinical Trials as Topic; Early Diagnosis; Humans; Immunologic Factors; Kidney; Losartan; Mutation; Myosin Heavy Chains; Nephrotic Syndrome; Nerve Tissue Proteins; Renal Insufficiency, Chronic; Rituximab; Urinary Tract | 2011 |
Biased agonism of the angiotensin II type 1 receptor.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Arrestins; beta-Arrestins; HEK293 Cells; Humans; Ligands; Losartan; MAP Kinase Signaling System; Protein Conformation; Receptor, Angiotensin, Type 1; Stress, Mechanical | 2012 |
Role of angiotensin II and oxidative stress in renal inflammation by hypernatremia: benefits of atrial natriuretic peptide, losartan, and tempol.
Topics: Angiotensin II; Animals; Atrial Natriuretic Factor; Cyclic N-Oxides; Humans; Hypernatremia; Losartan; Nephritis; Oxidative Stress; Spin Labels | 2015 |
Therapeutics Targeting Drivers of Thoracic Aortic Aneurysms and Acute Aortic Dissections: Insights from Predisposing Genes and Mouse Models.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aortic Aneurysm, Thoracic; Aortic Dissection; Disease Models, Animal; Genetic Predisposition to Disease; Humans; Losartan; Marfan Syndrome; Mechanoreceptors; Mice; Muscle, Smooth, Vascular; Signal Transduction; Transforming Growth Factor beta | 2017 |
Therapies for Thoracic Aortic Aneurysms and Acute Aortic Dissections.
Topics: Acute Disease; Angiotensin II; Animals; Aortic Aneurysm, Thoracic; Aortic Dissection; Humans; Losartan; Mice; Signal Transduction; Transforming Growth Factor beta | 2019 |
129 trial(s) available for losartan and angiotensin ii
| Article | Year |
|---|---|
Clinical experience with angiotensin II receptor antagonists.
Topics: Administration, Oral; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Humans; Hypertension; Imidazoles; Injections, Intravenous; Losartan; Renin-Angiotensin System; Tetrazoles; Time Factors | 1992 |
Drug concentration response relationships in normal volunteers after oral administration of losartan, an angiotensin II receptor antagonist.
Topics: Administration, Oral; Adult; Aldosterone; Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biotransformation; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Humans; Imidazoles; Losartan; Male; Reference Values; Renin; Tetrazoles | 1992 |
Dose-response relationships following oral administration of DuP 753 to normal humans.
Topics: Administration, Oral; Adult; Angiotensin II; Blood Pressure; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Imidazoles; Losartan; Male; Reference Values; Renin-Angiotensin System; Single-Blind Method; Tetrazoles | 1991 |
Oral administration of DuP 753, a specific angiotensin II receptor antagonist, to normal male volunteers. Inhibition of pressor response to exogenous angiotensin I and II.
Topics: Administration, Oral; Adult; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Blood Pressure; Drug Evaluation; Heart Rate; Humans; Imidazoles; Losartan; Male; Renin-Angiotensin System; Tetrazoles | 1991 |
Comparison of angiotensin-converting enzyme inhibition with angiotensin II receptor antagonism in the human forearm.
Topics: Adult; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Pressure; Bradykinin; Double-Blind Method; Drug Interactions; Enalapril; Forearm; Heart Rate; Humans; Imidazoles; Losartan; Male; Regional Blood Flow; Tetrazoles; Vascular Resistance; Vasoconstriction; Vasodilation | 1993 |
Effects of losartan on the renin-angiotensin-aldosterone axis in essential hypertension.
Topics: Aldosterone; Angiotensin II; Biphenyl Compounds; Blood Pressure; Creatinine; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Renin; Renin-Angiotensin System; Tetrazoles | 1995 |
Effects of losartan on a background of hydrochlorothiazide in patients with hypertension.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Diastole; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Posture; Potassium; Systole; Tetrazoles; Time Factors; Uric Acid | 1995 |
Dose-ranging study of the angiotensin type I receptor antagonist losartan (DuP753/MK954), in salt-deplete normal man.
Topics: Adult; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Pressure; Diet, Sodium-Restricted; Dose-Response Relationship, Drug; Double-Blind Method; Electrolytes; Furosemide; Heart Rate; Humans; Imidazoles; Losartan; Male; Natriuresis; Renin; Sodium; Tetrazoles | 1993 |
Pharmacodynamic activity of intravenous E-3174, an angiotensin II antagonist, in patients with essential hypertension.
Topics: Adult; Aged; Angiotensin II; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Imidazoles; Injections, Intravenous; Kidney Function Tests; Losartan; Male; Middle Aged; Renin; Tetrazoles; Uric Acid | 1994 |
Hemodynamic and humoral effects of the angiotensin II antagonist losartan in essential hypertension.
Topics: Adult; Aldosterone; Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Body Weight; Female; Heart Rate; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Neurotransmitter Agents; Nifedipine; Norepinephrine; Renin; Tetrazoles | 1994 |
Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Asthenia; Atenolol; Biphenyl Compounds; Cough; Dizziness; Double-Blind Method; Fatigue; Felodipine; Female; Headache; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Placebos; Respiratory Tract Infections; Safety; Tetrazoles | 1995 |
A randomized, placebo-controlled, double-blind, parallel study of various doses of losartan potassium compared with enalapril maleate in patients with essential hypertension.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Enalapril; Female; Humans; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Tetrazoles | 1995 |
Losartan in heart failure. Hemodynamic effects and tolerability. Losartan Hemodynamic Study Group.
Topics: Aged; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Double-Blind Method; Female; Heart Failure; Hemodynamics; Humans; Imidazoles; Losartan; Male; Middle Aged; Norepinephrine; Renin; Tetrazoles | 1995 |
Biochemical effects of losartan, a nonpeptide angiotensin II receptor antagonist, on the renin-angiotensin-aldosterone system in hypertensive patients.
Topics: Adult; Aged; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Double-Blind Method; Enalapril; Female; Humans; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Norepinephrine; Renin; Renin-Angiotensin System; Tetrazoles | 1995 |
Blood pressure effects of the angiotensin II receptor blocker, losartan.
Topics: Adult; Aged; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Double-Blind Method; Humans; Imidazoles; Least-Squares Analysis; Losartan; Middle Aged; Tetrazoles | 1995 |
Effects of the angiotensin II antagonist losartan in hypertensive patients with renal disease.
Topics: Albuminuria; Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Female; Glomerular Filtration Rate; Humans; Hypertension, Renal; Imidazoles; Longitudinal Studies; Losartan; Male; Proteinuria; Renal Circulation; Single-Blind Method; Tetrazoles; Uric Acid | 1994 |
Association between cough and angiotensin converting enzyme inhibitors versus angiotensin II antagonists: the design of a prospective, controlled study.
Topics: Adult; Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Cough; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Lisinopril; Losartan; Male; Prospective Studies; Research Design; Surveys and Questionnaires; Tetrazoles | 1994 |
Is the antiproteinuric effect of ACE inhibition mediated by interference in the renin-angiotensin system?
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Pressure; Enalapril; Female; Humans; Hypertension; Imidazoles; Kidney; Losartan; Male; Middle Aged; Proteinuria; Renal Circulation; Renin-Angiotensin System; Tetrazoles | 1994 |
Salt-dependent renal effects of an angiotensin II antagonist in healthy subjects.
Topics: Adult; Aldosterone; Angiotensin II; Biphenyl Compounds; Blood Pressure; Double-Blind Method; Electrolytes; Glomerular Filtration Rate; Hemodynamics; Humans; Imidazoles; Kidney; Lithium; Losartan; Male; Renal Circulation; Renin; Sodium, Dietary; Tetrazoles; Uric Acid; Urine | 1993 |
Clinical pharmacology of angiotensin and bradykinin in human forearm vasculature.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Vessels; Bradykinin; Enalapril; Forearm; Humans; Imidazoles; Losartan; Peptidyl-Dipeptidase A; Renin-Angiotensin System; Tetrazoles | 1993 |
Hemodynamic and neurohormonal effects of the angiotensin II antagonist losartan in patients with congestive heart failure.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation; Female; Heart Failure; Hemodynamics; Humans; Imidazoles; Losartan; Male; Middle Aged; Norepinephrine; Renin-Angiotensin System; Tetrazoles | 1993 |
Pharmacokinetics and biochemical efficacy after single and multiple oral administration of losartan, an orally active nonpeptide angiotensin II receptor antagonist, in humans.
Topics: Administration, Oral; Adult; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Pressure; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Heart Rate; Humans; Imidazoles; Losartan; Male; Middle Aged; Renin; Tetrazoles | 1993 |
Effects of losartan on blood pressure, plasma renin activity, and angiotensin II in volunteers.
Topics: Adolescent; Adult; Angiotensin II; Biphenyl Compounds; Blood Pressure; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Double-Blind Method; Heart Rate; Humans; Imidazoles; Losartan; Male; Osmolar Concentration; Radioimmunoassay; Reference Values; Renin; Renin-Angiotensin System; Tetrazoles | 1993 |
Differential effects of oral losartan and enalapril on local venous and systemic pressor responses to angiotensin I and II in healthy men.
Topics: Administration, Oral; Adult; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Double-Blind Method; Enalapril; Hand; Humans; Imidazoles; Losartan; Male; Reference Values; Renin; Tetrazoles; Vasoconstriction; Veins | 1996 |
Acute hypoxic pulmonary vasoconstriction in man is attenuated by type I angiotensin II receptor blockade.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Pressure; Heart Rate; Humans; Hypoxia; Imidazoles; Losartan; Male; Pulmonary Artery; Receptors, Angiotensin; Tetrazoles; Vascular Resistance; Vasoconstriction | 1995 |
Renal effects of angiotensin I-receptor blockade and angiotensin convertase inhibition in man.
Topics: Adult; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Compounds; Blood Pressure; Double-Blind Method; Drug Synergism; Enalapril; Humans; Imidazoles; Kidney; Losartan; Male; Peptidyl-Dipeptidase A; Regional Blood Flow; Renal Circulation; Renin; Tetrazoles | 1996 |
Effects of losartan on renal function in patients with essential hypertension.
Topics: Albuminuria; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Imidazoles; Kidney; Losartan; Male; Middle Aged; Renal Circulation; Single-Blind Method; Sodium; Tetrazoles; Uric Acid | 1996 |
Effects of losartan on vasoconstrictor responses to angiotensin II in the forearm vascular bed of healthy volunteers.
Topics: Administration, Oral; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Depression, Chemical; Dose-Response Relationship, Drug; Forearm; Humans; Imidazoles; Infusions, Intra-Arterial; Losartan; Male; Plethysmography; Tetrazoles; Vascular Resistance; Vasoconstrictor Agents | 1996 |
Losartan blocks aldosterone and renal vascular responses to angiotensin II in humans.
Topics: Aldosterone; Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Interactions; Humans; Imidazoles; Infusions, Intravenous; Kidney; Losartan; Male; Renal Circulation; Renin; Sodium Chloride, Dietary; Tetrazoles | 1996 |
Comparison of the angiotensin II antagonist losartan with the angiotensin converting enzyme inhibitor enalapril in patients with essential hypertension.
Topics: Adult; Aged; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Compounds; Blood Pressure; Cough; Diastole; Double-Blind Method; Enalapril; Female; Humans; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Systole; Tetrazoles | 1995 |
The effect of angiotensin II receptor antagonism with losartan on glucose metabolism and insulin sensitivity.
Topics: Adult; Aged; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Pressure; Female; Glucose; Glucose Tolerance Test; Heart Rate; Humans; Imidazoles; Insulin; Lipids; Losartan; Male; Middle Aged; Tetrazoles | 1996 |
The effects of angiotensin II receptor blockade with losartan on systemic blood pressure and renal and extrarenal prostaglandin synthesis in women with essential hypertension.
Topics: Aged; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Female; Humans; Hypertension; Imidazoles; Kidney; Losartan; Middle Aged; Prostaglandins; Renin; Single-Blind Method; Tetrazoles; Uric Acid | 1995 |
[The first clinical experience in Italy with angiotensin II receptor antagonists: results of a multicenter study on the efficacy and tolerance in arterial hypertension].
Topics: Adult; Aged; Amlodipine; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Double-Blind Method; Female; Humans; Hypertension; Imidazoles; Italy; Losartan; Male; Middle Aged; Tetrazoles | 1995 |
DuP 532, an angiotensin II receptor antagonist: first administration and comparison with losartan.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Pressure; Double-Blind Method; Heart Rate; Humans; Imidazoles; Losartan; Male; Renin; Tetrazoles | 1997 |
Additive effects of losartan and enalapril on blood pressure and plasma active renin.
Topics: Adolescent; Adult; Aldosterone; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Enalapril; Heart Rate; Humans; Hydrocortisone; Imidazoles; Losartan; Male; Peptidyl-Dipeptidase A; Renin; Tetrazoles; Time Factors | 1997 |
Haemodynamic and endocrine effects of type 1 angiotensin II receptor blockade in patients with hypoxaemic cor pulmonale.
Topics: Aged; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Cross-Over Studies; Double-Blind Method; Echocardiography, Doppler, Pulsed; Female; Humans; Hypertension, Pulmonary; Imidazoles; Losartan; Lung Diseases, Obstructive; Male; Pulmonary Heart Disease; Tetrazoles; Vascular Resistance | 1997 |
AT1 receptor blockade and the sympathoadrenal response to insulin-induced hypoglycemia in humans.
Topics: Adrenal Medulla; Adult; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Glucose; Blood Pressure; Catecholamines; Female; Heart Rate; Humans; Imidazoles; Insulin; Losartan; Male; Receptor, Angiotensin, Type 1; Regional Blood Flow; Renin; Sympathetic Nervous System; Tetrazoles | 1997 |
Effects of angiotensin II receptor blockade on N-terminal proatrial natriuretic factor plasma levels in chronic heart failure.
Topics: Aged; Angiotensin II; Angiotensin Receptor Antagonists; Atrial Natriuretic Factor; Biphenyl Compounds; Double-Blind Method; Female; Heart Failure; Hemodynamics; Humans; Imidazoles; Losartan; Male; Middle Aged; Protein Precursors; Tetrazoles | 1997 |
The Losartan Intervention For Endpoint reduction (LIFE) in Hypertension study: rationale, design, and methods. The LIFE Study Group.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Atenolol; Biphenyl Compounds; Blood Pressure; Double-Blind Method; Echocardiography; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Imidazoles; Losartan; Male; Middle Aged; Research Design; Tetrazoles; Treatment Outcome | 1997 |
Angiotensin II blockade does not prevent renal effects of L-NAME in sodium-repleted humans.
Topics: Adult; Angiotensin II; Biphenyl Compounds; Enzyme Inhibitors; Female; Humans; Imidazoles; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Sodium, Dietary; Tetrazoles | 1997 |
Effects of losartan on cerebral and ocular circulation in healthy subjects.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Flow Velocity; Brain; Cross-Over Studies; Double-Blind Method; Echoencephalography; Eye; Hemodynamics; Humans; Losartan; Male; Random Allocation; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Ultrasonography, Doppler | 1997 |
Influence of indomethacin and L-NMMA on vascular tone and angiotensin II-induced vasoconstriction in the human forearm.
Topics: Adult; Angiotensin II; Antihypertensive Agents; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Forearm; Humans; Indomethacin; Losartan; Male; omega-N-Methylarginine; Regional Blood Flow; Vasoconstriction; Vasoconstrictor Agents; Vasomotor System | 1997 |
The effects of thromboxane A2 inhibition (picotamide) and angiotensin II receptor blockade (losartan) in primary Raynaud's phenomenon.
Topics: Adolescent; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Pressure; Cross-Over Studies; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Losartan; Male; Phthalic Acids; Platelet Aggregation Inhibitors; Plethysmography; Raynaud Disease; Single-Blind Method; Thromboxane A2; Treatment Outcome | 1997 |
[AT1 angiotensin receptor inhibition as a new therapeutic possibility].
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Female; Heart Failure; Humans; Hypertension; Losartan; Renin-Angiotensin System | 1997 |
Endogenous angiotensin II contributes to basal peripheral vascular tone in sodium deplete but not sodium replete man.
Topics: Adult; Analysis of Variance; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Vessels; Bradykinin; Diuretics; Dose-Response Relationship, Drug; Forearm; Furosemide; Humans; Losartan; Lower Body Negative Pressure; Male; Norepinephrine; Regional Blood Flow; Sodium; Sodium, Dietary; Vasoconstriction; Vasoconstrictor Agents | 1997 |
Captopril plus losartan in early post-infarction. Neurohormonal effects: a pilot study.
Topics: Aged; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Captopril; Drug Therapy, Combination; Female; Humans; Losartan; Male; Middle Aged; Myocardial Infarction; Norepinephrine; Pilot Projects; Single-Blind Method; Time Factors | 1997 |
The antihypertensive effect and tolerability of candesartan cilexetil, a new generation angiotensin II antagonist, in comparison with losartan.
Topics: Adult; Angiotensin II; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Losartan; Male; Middle Aged; Tetrazoles; Treatment Outcome | 1998 |
A radioreceptor assay for the analysis of AT1-receptor antagonists. Correlation with complementary LC data reveals a potential contribution of active metabolites.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Proteins; Chromatography, High Pressure Liquid; Double-Blind Method; Humans; Imidazoles; Losartan; Male; Placebos; Pyrimidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Angiotensin; Reference Values; Sensitivity and Specificity; Tetrazoles | 1998 |
Stimulation of ACTH and GH release by angiotensin II in normal men is mediated by the AT1 receptor subtype.
Topics: Adrenocorticotropic Hormone; Adult; Angiotensin II; Antihypertensive Agents; Blood Pressure; Human Growth Hormone; Humans; Losartan; Male; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reference Values | 1998 |
ACE inhibition but not angiotensin II antagonism reduces plasma fibrinogen and insulin resistance in overweight hypertensive patients.
Topics: Adult; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Cross-Over Studies; Double-Blind Method; Female; Fibrinogen; Hemodynamics; Humans; Hypertension; Indoles; Insulin Resistance; Losartan; Male; Middle Aged; Obesity; Perindopril | 1998 |
Improved exercise tolerance after losartan and enalapril in heart failure: correlation with changes in skeletal muscle myosin heavy chain composition.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Enalapril; Exercise Tolerance; Heart Failure; Humans; Losartan; Male; Middle Aged; Muscle, Skeletal; Myosin Heavy Chains | 1998 |
Regulation of peripheral vascular tone in patients with heart failure: contribution of angiotensin II.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Endothelin-1; Female; Forearm; Heart Failure; Humans; Infusions, Intra-Arterial; Losartan; Lower Body Negative Pressure; Male; Middle Aged; Norepinephrine; Plethysmography; Regional Blood Flow; Vascular Resistance; Vasoconstrictor Agents | 1998 |
Endogenous angiotensin II and baroreceptor dysfunction: a comparative study of losartan and enalapril in man.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Baroreflex; Blood Pressure; Double-Blind Method; Enalapril; Heart Rate; Humans; Losartan; Male; Pressoreceptors; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin-Angiotensin System | 1998 |
Angiotensin-converting enzyme inhibitors but not angiotensin II AT 1 receptor antagonists affect erythropoiesis in patients with anemia of end-stage renal disease.
Topics: Anemia; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Captopril; Erythropoiesis; Female; Humans; Kidney Failure, Chronic; Losartan; Male; Middle Aged | 1999 |
Angiotensin II receptor blockade in normotensive subjects: A direct comparison of three AT1 receptor antagonists.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Double-Blind Method; Humans; Irbesartan; Losartan; Male; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles; Time Factors; Valine; Valsartan | 1999 |
Does the addition of losartan improve the beneficial effects of ACE inhibitors in patients with anterior myocardial infarction? A pilot study.
Topics: Aged; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Blood Pressure; Captopril; Drug Therapy, Combination; Female; Follow-Up Studies; Hemodynamics; Humans; Losartan; Male; Middle Aged; Myocardial Infarction; Norepinephrine; Pilot Projects; Single-Blind Method | 1999 |
Pharmacokinetic-pharmacodynamic interactions of candesartan cilexetil and losartan.
Topics: Administration, Oral; Adolescent; Adult; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Double-Blind Method; Humans; Losartan; Male; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin; Tetrazoles | 1999 |
Losartan decreases plasma levels of TGF-beta1 in transplant patients with chronic allograft nephropathy.
Topics: Adult; Aged; Angiotensin II; Antihypertensive Agents; Blood Pressure; Chronic Disease; Endothelins; Female; Fibrosis; Follow-Up Studies; Graft Rejection; Humans; Kidney; Kidney Failure, Chronic; Kidney Transplantation; Losartan; Male; Middle Aged; Pilot Projects; Proteinuria; Transforming Growth Factor beta; Transplantation, Homologous; Vasoconstrictor Agents | 1999 |
Impact of hyperglycemia on the renin angiotensin system in early human type 1 diabetes mellitus.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Blood Pressure; Cross-Over Studies; Diabetes Mellitus, Type 1; Female; Glomerular Filtration Rate; Humans; Hyperglycemia; Kidney; Losartan; Male; Natriuresis; Renal Circulation; Renin-Angiotensin System; Vascular Resistance | 1999 |
Time course and extent of angiotensin II antagonism after irbesartan, losartan, and valsartan in humans assessed by angiotensin II dose response and radioligand receptor assay.
Topics: Adult; Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Chromatography, High Pressure Liquid; Confounding Factors, Epidemiologic; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Half-Life; Humans; Irbesartan; Losartan; Male; Radioligand Assay; Reference Values; Tetrazoles; Time Factors; Valine; Valsartan | 1999 |
Angiotensin II increases erythropoietin production in healthy human volunteers.
Topics: Adult; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Captopril; Erythropoietin; Heart Rate; Hematocrit; Hemoglobins; Hemorrhage; Humans; Infusions, Intravenous; Losartan; Male; Phlebotomy; Placebos | 1999 |
Comparison of angiotensin II receptor blockers: impact of missed doses of candesartan cilexetil and losartan in systemic hypertension.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Data Interpretation, Statistical; Drug Administration Schedule; Humans; Hypertension; Hypertrophy, Left Ventricular; Losartan; Middle Aged; Patient Compliance; Randomized Controlled Trials as Topic; Tetrazoles; Treatment Outcome | 1999 |
Angiotensin II type 1 receptor gene polymorphism predicts response to losartan and angiotensin II.
Topics: Adult; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Pressure; Female; Glomerular Filtration Rate; Humans; Kidney; Losartan; Male; Polymorphism, Single Nucleotide; Predictive Value of Tests; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renal Circulation; Vasoconstrictor Agents | 1999 |
Effects of angiotensin converting enzyme and angiotensin II receptor inhibition on impaired fibrinolysis in systemic hypertension.
Topics: Adolescent; Adult; Aged; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Bradykinin; Female; Fibrinolysis; Fibrinolytic Agents; Humans; Hypertension; Lipoproteins; Losartan; Male; Middle Aged; Perindopril; Plasminogen Activator Inhibitor 1; Thrombomodulin; Tissue Plasminogen Activator | 1999 |
Assessment of angiotensin II receptor blockade in humans using a standardized angiotensin II receptor-binding assay.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biomarkers; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Double-Blind Method; Humans; Hypertension; Irbesartan; Losartan; Radioligand Assay; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Reproducibility of Results; Tetrazoles; Valine; Valsartan; Vasoconstrictor Agents | 1999 |
Comparative study of ACE-inhibition, angiotensin II antagonism, and calcium channel blockade on flow-mediated vasodilation in patients with coronary disease (BANFF study)
Topics: Aged; Amlodipine; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Blood Flow Velocity; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Drug Therapy, Combination; Enalapril; Endothelium, Vascular; Female; Humans; Isoquinolines; Losartan; Male; Middle Aged; Quinapril; Tetrahydroisoquinolines; Vasodilation | 2000 |
Pharmacologic profile of UR-7247, an orally active angiotensin II AT1 receptor antagonist, in healthy volunteers. p6.
Topics: Administration, Oral; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Humans; Losartan; Male; Pyrazoles; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2 | 2000 |
Functional importance of angiotensin-converting enzyme-dependent in situ angiotensin II generation in the human forearm.
Topics: Adolescent; Adult; Aged; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Brachial Artery; Enalaprilat; Endothelium, Vascular; Forearm; Humans; Losartan; Male; Middle Aged; Peptidyl-Dipeptidase A; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Regional Blood Flow; Vasoconstriction | 2000 |
Dose-dependent effect of angiotensin II on human erythropoietin production.
Topics: Adolescent; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Area Under Curve; Dose-Response Relationship, Drug; Drug Combinations; Erythropoietin; Humans; Losartan; Male; Osmolar Concentration; Renin; Time Factors; Vasoconstrictor Agents | 2000 |
Fibrinolytic function in diuretic-induced volume depletion.
Topics: Adult; Angiotensin II; Antihypertensive Agents; Blood Volume; Diuretics; Drug Therapy, Combination; Fibrinolysis; Humans; Hydrochlorothiazide; Hypertension, Renal; Losartan; Male; Plasminogen Activator Inhibitor 1; Renin; Sodium Chloride Symporter Inhibitors; Tissue Plasminogen Activator | 2000 |
Acute and chronic angiotensin-1 receptor antagonism reverses endothelial dysfunction in atherosclerosis.
Topics: Acetylcholine; Angiotensin II; Angiotensin Receptor Antagonists; Arteriosclerosis; Brachial Artery; Endothelium, Vascular; Female; Femoral Artery; Humans; Hyperemia; Losartan; Male; Middle Aged; Nitroprusside; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Regional Blood Flow; Single-Blind Method; Time Factors; Vascular Resistance; Vasodilation; Vasodilator Agents | 2000 |
Effects of angiotensin II blockade on nitric oxide blood levels in IgA nephropathy.
Topics: Adult; Aged; Albuminuria; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Enalapril; Female; Glomerulonephritis, IGA; Hemoglobins; Humans; Isosorbide Dinitrate; Losartan; Male; Middle Aged; Nitric Oxide; Nitric Oxide Donors; Reference Values; Renal Circulation | 2000 |
The efficacy and tolerability of losartan versus atenolol in patients with isolated systolic hypertension. Losartan ISH Investigators Group.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin II; Antihypertensive Agents; Atenolol; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Systole; Treatment Outcome | 2000 |
Influence of losartan on alpha-adrenoceptor-mediated vasoconstrictor response in humans.
Topics: Adult; Analysis of Variance; Angiotensin II; Antihypertensive Agents; Blood Pressure; Cross-Over Studies; Fingers; Heart Rate; Humans; Losartan; Male; Phenylephrine; Receptors, Adrenergic, alpha; Vasoconstriction; Vasoconstrictor Agents | 2000 |
Pilot study of combined blockade of the renin-angiotensin system in essential hypertensive patients.
Topics: Adolescent; Adult; Aged; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biomarkers; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Enalapril; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Pilot Projects; Renin-Angiotensin System; Treatment Outcome | 2000 |
Comparative study of the cardiovascular effects of losartan in normal and in water- and salt-depleted sheep.
Topics: Angiotensin II; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Blood Pressure; Cardiovascular System; Diet, Sodium-Restricted; Diuretics; Drug Interactions; Heart Rate; Losartan; Renin; Sheep; Water Deprivation | 2000 |
Transforming growth factor beta in hypertensives with cardiorenal damage.
Topics: Albuminuria; Angiotensin II; Antihypertensive Agents; Collagen; Collagen Type I; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Losartan; Male; Middle Aged; Peptide Fragments; Peptides; Procollagen; Transforming Growth Factor beta; Transforming Growth Factor beta1; Treatment Outcome | 2000 |
Effect of losartan on angiotensin II-mediated endothelin and prostanoid excretion in humans.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Blood Pressure; Cross-Over Studies; Double-Blind Method; Endothelin-1; Humans; Losartan; Male; Middle Aged; Placebos; Prostaglandins; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin | 2000 |
Effect of angiotensin II on venodilator response to nitroglycerin.
Topics: Adult; Analysis of Variance; Angiotensin II; Anti-Arrhythmia Agents; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Humans; Infusions, Intravenous; Losartan; Male; Middle Aged; Nitroglycerin; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2001 |
Effects of losartan and amlodipine on intrarenal hemodynamics and TGF-beta(1) plasma levels in a crossover trial in renal transplant recipients.
Topics: Amlodipine; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cross-Over Studies; Endothelin-1; Female; Hemodynamics; Humans; Kidney; Kidney Transplantation; Losartan; Male; Middle Aged; Renal Circulation; Renin; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2001 |
Endothelial function during stimulation of renin-angiotensin system by low-sodium diet in humans.
Topics: Adult; Angiotensin II; Antihypertensive Agents; Blood Pressure; Endothelium, Vascular; Female; Forearm; Humans; Losartan; Male; Methacholine Chloride; Nitric Oxide; Parasympathomimetics; Renin-Angiotensin System; Sodium; Sodium, Dietary; Vasodilation | 2001 |
Dose-dependent blockade of the angiotensin II type 1 receptor with losartan in normal volunteers.
Topics: Adult; Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Female; Humans; Losartan; Male; Middle Aged; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles; Vasoconstrictor Agents | 2001 |
Angiotensin II and prostaglandin interactions on systemic and renal effects of L-NAME in humans.
Topics: Adult; Angiotensin II; Blood Pressure; Cyclooxygenase Inhibitors; Drug Synergism; Enzyme Inhibitors; Female; Humans; Indomethacin; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Prostaglandins; Renal Circulation; Sodium; Vasoconstriction | 2001 |
Differential effects of ACE-inhibition and angiotensin II antagonism on fibrinolysis and insulin sensitivity in hypertensive postmenopausal women.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Glucose; Blood Pressure; Double-Blind Method; Female; Fibrinolysis; Humans; Hypertension; Indoles; Insulin; Insulin Resistance; Lipids; Losartan; Middle Aged; Plasminogen Activator Inhibitor 1; Postmenopause; Sensitivity and Specificity; Women's Health | 2001 |
[Effect of losartan on renal and cardiovascular complications of patients with type 2 diabetes and nephropathy].
Topics: Adult; Aged; Angiotensin II; Antihypertensive Agents; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Double-Blind Method; Humans; Losartan; Male; Middle Aged; Renin-Angiotensin System | 2001 |
Radial artery flow-mediated dilatation in heart failure patients: effects of pharmacological and nonpharmacological treatment.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Blood Flow Velocity; Drug Administration Schedule; Echocardiography, Doppler; Enalapril; Exercise Test; Exercise Therapy; Female; Heart Failure; Humans; Losartan; Male; Middle Aged; Radial Artery; Vasodilation | 2001 |
Effects of losartan and its combination with quinapril on the cardiac sympathetic nervous system and neurohormonal status in essential hypertension.
Topics: 3-Iodobenzylguanidine; Adult; Aged; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Drug Therapy, Combination; Female; Heart; Hemodynamics; Humans; Hypertension; Isoquinolines; Losartan; Male; Middle Aged; Quinapril; Radionuclide Imaging; Radiopharmaceuticals; Renin; Renin-Angiotensin System; Sympathetic Nervous System; Tetrahydroisoquinolines; Treatment Outcome | 2002 |
Stimulation of cardiac apoptosis in essential hypertension: potential role of angiotensin II.
Topics: Adult; Aged; Amlodipine; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Apoptosis; bcl-2-Associated X Protein; Blood Pressure; Calcium Channel Blockers; Female; Heart Ventricles; Humans; Hypertension; Losartan; Male; Middle Aged; Myocardium; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Receptor, Angiotensin, Type 1 | 2002 |
Comparative angiotensin II receptor blockade in healthy volunteers: the importance of dosing.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cross-Over Studies; Dose-Response Relationship, Drug; Humans; Irbesartan; Losartan; Male; Renin; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan | 2002 |
Angiotensin II type 1 receptor antagonist, losartan, causes regression of left ventricular hypertrophy in end-stage renal disease.
Topics: Adult; Aged; Aged, 80 and over; Amlodipine; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Echocardiography; Enalapril; Female; Heart Ventricles; Humans; Hypertension; Hypertrophy, Left Ventricular; Kidney Failure, Chronic; Losartan; Male; Middle Aged; Receptor, Angiotensin, Type 1; Renal Dialysis | 2002 |
[Effect of long-term treatment with enalapril, losartan and their combination on the quality of life of patients with congestive heart failure].
Topics: Adult; Aged; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Drug Therapy, Combination; Enalapril; Heart Failure; Humans; Losartan; Middle Aged; Quality of Life; Receptor, Angiotensin, Type 1 | 2002 |
Losartan may modulate erythropoietin production.
Topics: Adult; Angiotensin II; Antihypertensive Agents; Blood Pressure; Erythropoietin; Female; Glomerular Filtration Rate; Humans; Losartan; Male; Renin-Angiotensin System; Sodium; Vasoconstrictor Agents; Water-Electrolyte Balance | 2001 |
A low-sodium diet potentiates the effects of losartan in type 2 diabetes.
Topics: Albuminuria; Aldosterone; Angiotensin II; Antihypertensive Agents; Blood Glucose; Blood Pressure; Creatinine; Diabetes Mellitus, Type 2; Diet, Sodium-Restricted; Drug Synergism; Female; Hemodynamics; Humans; Losartan; Male; Middle Aged; Placebos; Renal Circulation; Renin; Sodium | 2002 |
Short-term effects of angiotensin II receptor blockade in patients with primary glomerulonephritis: pilot study.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Female; Glomerulonephritis; Humans; Losartan; Male; Middle Aged; Pilot Projects; Time Factors | 2002 |
Angiotensin II receptor-independent antiinflammatory and antiaggregatory properties of losartan: role of the active metabolite EXP3179.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Arachidonic Acid; Biotransformation; Cells, Cultured; Cyclooxygenase 2; Dinoprost; Drug Design; Endothelium, Vascular; Enzyme Activation; Female; Humans; Hypertension; Imidazoles; Inflammation; Intercellular Adhesion Molecule-1; Isoenzymes; Lipopolysaccharides; Losartan; Male; Membrane Proteins; Middle Aged; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; RNA, Messenger; Tetrazoles; Thromboxane A2; Up-Regulation; Vasoconstrictor Agents | 2002 |
Angiotensin-II receptor antagonist losartan reduces microalbuminuria in hypertensive renal transplant recipients.
Topics: Adolescent; Adult; Albuminuria; Angiotensin II; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension; Kidney Transplantation; Losartan; Male; Middle Aged | 2002 |
The impact of angiotensin II receptor blockade and the DASH diet on markers of endogenous fibrinolysis.
Topics: Angiotensin II; Antihypertensive Agents; Blood Pressure; Diet, Sodium-Restricted; Female; Fibrinolysis; Humans; Hypertension; Losartan; Male; Middle Aged; Plasminogen Activator Inhibitor 1; Renin; Tissue Plasminogen Activator | 2002 |
Effects of enalapril and losartan on circulating adhesion molecules and monocyte chemotactic protein-1.
Topics: Aged; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Cell Adhesion Molecules; Chemokine CCL2; Double-Blind Method; E-Selectin; Enalapril; Enzyme Inhibitors; Female; Humans; Hypertension; Intercellular Adhesion Molecule-1; Losartan; Male; Middle Aged; Prospective Studies; Vascular Cell Adhesion Molecule-1 | 2002 |
Augmentation of myocardial blood flow in hypertensive heart disease by angiotensin antagonists: a comparison of lisinopril and losartan.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Coronary Circulation; Female; Heart Ventricles; Humans; Hypertension; Hypertrophy, Left Ventricular; Lisinopril; Losartan; Male; Middle Aged; Tomography, Emission-Computed | 2002 |
Prevention of cardiovascular morbidity with angiotension receptor blockade: life after LIFE.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Atenolol; Clinical Protocols; Diabetes Complications; Humans; Hypertension; Hypertrophy, Left Ventricular; Losartan; Morbidity; Risk | 2002 |
Influence of AT1 receptor blockade on blood pressure, renal haemodynamics and hormonal responses to intravenous angiotensin II infusion in hypertensive patients.
Topics: Adult; Aged; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Hemodynamics; Humans; Hypertension; Infusions, Intravenous; Losartan; Male; Middle Aged; Receptor, Angiotensin, Type 1; Renal Circulation; Renin; Tetrazoles; Valine; Valsartan | 2002 |
Effect of angiotensin ii receptor blockade on arterial stiffness: beyond blood pressure reduction.
Topics: Aged; Angiotensin II; Antihypertensive Agents; Aorta; Blood Pressure; Brachial Artery; Cross-Over Studies; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Treatment Outcome; Vascular Resistance | 2002 |
Losartan in diabetic nephropathy.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dose-Response Relationship, Drug; Humans; Kidney Failure, Chronic; Losartan; Receptor, Angiotensin, Type 1 | 2003 |
Role of angiotensin II in L-NAME-induced systemic and renal hemodynamic effects in hydrochlorothiazide-pretreated hypertensive subjects.
Topics: Angiotensin II; Antihypertensive Agents; Diuresis; Diuretics; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Glomerular Filtration Rate; Hemodynamics; Hormones; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Natriuresis; NG-Nitroarginine Methyl Ester; Renal Circulation; Sodium Chloride Symporter Inhibitors | 2003 |
Angiotensin II AT1 receptor antagonism prevents detrimental renal actions of acute diuretic therapy in human heart failure.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Cross-Over Studies; Diuretics; Double-Blind Method; Drug Therapy, Combination; Furosemide; Glomerular Filtration Rate; Heart Failure; Humans; Kidney; Kidney Diseases; Losartan; Receptor, Angiotensin, Type 1; Renal Circulation; Renin | 2003 |
Portal pressure response to losartan compared with propranolol in patients with cirrhosis.
Topics: Adrenergic beta-Antagonists; Adult; Angiotensin II; Antihypertensive Agents; Esophageal and Gastric Varices; Female; Hemodynamics; Humans; Hypertension, Portal; Liver Cirrhosis; Losartan; Male; Middle Aged; Portal Vein; Propranolol | 2003 |
Combined inhibition of angiotensin II and endothelin suppresses the brain natriuretic peptide response to developing heart failure.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Bosentan; Cardiac Output; Cardiac Output, Low; Cardiac Pacing, Artificial; Cyclic GMP; Endothelin Receptor Antagonists; Endothelin-1; Female; Infusions, Parenteral; Losartan; Natriuretic Peptide, Brain; Renin; Sheep; Sulfonamides | 2004 |
Effects of losartan and captopril on left ventricular systolic and diastolic function after acute myocardial infarction: results of the Optimal Trial in Myocardial Infarction with Angiotensin II Antagonist Losartan (OPTIMAAL) echocardiographic substudy.
Topics: Aged; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Captopril; Double-Blind Method; Echocardiography; Electrocardiography; Female; Humans; Losartan; Male; Middle Aged; Myocardial Infarction; Ventricular Function, Left | 2004 |
Rationale for the use of combination angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker therapy in heart failure.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Drug Synergism; Drug Therapy, Combination; Exercise Tolerance; Female; Heart Failure; Heart Function Tests; Humans; Losartan; Male; Middle Aged; Natriuretic Peptide, Brain; Receptors, Angiotensin; Renin; Tetrazoles; Valine; Valsartan | 2004 |
Bradykinin contributes to the systemic hemodynamic effects of chronic angiotensin-converting enzyme inhibition in patients with heart failure.
Topics: Aged; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Cardiac Output; Cross-Over Studies; Double-Blind Method; Enalapril; Female; Forearm; Heart Failure; Heart Rate; Hemodynamics; Humans; Losartan; Male; Middle Aged; Peptidyl-Dipeptidase A; Regional Blood Flow; Vasodilation | 2004 |
Comparison of effects of losartan, irbesartan, and candesartan on flow-mediated brachial artery dilation and on inflammatory and thrombolytic markers in patients with systemic hypertension.
Topics: Angiotensin II; Antihypertensive Agents; Benzimidazoles; Biomarkers; Biphenyl Compounds; Brachial Artery; Double-Blind Method; Female; Humans; Hypertension; Irbesartan; Losartan; Male; Middle Aged; Tetrazoles; Vasodilation | 2004 |
Tonic levels of angiotensin II reduce tonic levels of vascular nitric oxide even in salt-replete man.
Topics: Acetylcholine; Adult; Angiotensin II; Antihypertensive Agents; Blood Pressure; Brachial Artery; Cross-Over Studies; Enzyme Inhibitors; Humans; Losartan; Male; Nitric Oxide; Nitroprusside; omega-N-Methylarginine; Regional Blood Flow; Renin-Angiotensin System; Sodium Chloride, Dietary; Vasodilator Agents | 2004 |
Disparate systemic and renal blocking properties of angiotensin II antagonists during exogenous angiotensin II administration: implications for treatment.
Topics: Adult; Aged; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biphenyl Compounds; Child; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Hemodynamics; Humans; Hypertension; Kidney; Losartan; Middle Aged; Renal Circulation; Renin; Tetrazoles | 2004 |
Losartan increases bradykinin levels in hypertensive humans.
Topics: Acrylates; Adolescent; Adult; Aged; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Bradykinin; Chromatography, High Pressure Liquid; Cross-Over Studies; Double-Blind Method; Female; Humans; Hydroxylation; Hypertension; Imidazoles; Kallidin; Losartan; Male; Middle Aged; Peptide Fragments; Radioimmunoassay; Thiophenes | 2005 |
Adverse effects of left ventricular hypertrophy in the reduction of endpoints in NIDDM with the angiotensin II antagonist losartan (RENAAL) study.
Topics: Aged; Angiotensin II; Antihypertensive Agents; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Electrocardiography; Endpoint Determination; Female; Humans; Hypertrophy, Left Ventricular; Losartan; Male; Middle Aged; Risk Assessment; Treatment Outcome | 2005 |
Angiotensin receptor blockade and exercise capacity in adults with systemic right ventricles: a multicenter, randomized, placebo-controlled clinical trial.
Topics: Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Cross-Over Studies; Double-Blind Method; Echocardiography, Transesophageal; Epinephrine; Exercise; Humans; Losartan; Natriuretic Peptide, Brain; Norepinephrine; Oxygen Consumption; Peptide Fragments; Transposition of Great Vessels; Treatment Outcome; Ventricular Dysfunction, Right | 2005 |
Dual blockade of angiotensin II with enalapril and losartan reduces proteinuria in hypertensive patients with type 2 diabetes.
Topics: Aged; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; C-Reactive Protein; Cystatin C; Cystatins; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Enalapril; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Natriuretic Peptide, Brain; Proteinuria; Transforming Growth Factor beta | 2006 |
Urinary angiotensinogen as a marker of intrarenal angiotensin II activity associated with deterioration of renal function in patients with chronic kidney disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angiotensin II; Angiotensinogen; Antihypertensive Agents; Biomarkers; Collagen Type I; Female; Humans; Kidney; Losartan; Male; Middle Aged; Renal Insufficiency, Chronic | 2007 |
Albuminuria is a target for renoprotective therapy independent from blood pressure in patients with type 2 diabetic nephropathy: post hoc analysis from the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial.
Topics: Aged; Albuminuria; Angiotensin II; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Placebos | 2007 |
Intradermal angiotensin II administration attenuates the local cutaneous vasodilator heating response.
Topics: Administration, Cutaneous; Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Antioxidants; Ascorbic Acid; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Hot Temperature; Humans; Imidazoles; Infusions, Parenteral; Losartan; Male; Microdialysis; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Pyridines; Receptor, Angiotensin, Type 2; Regional Blood Flow; Skin; Skin Temperature; Vasoconstrictor Agents; Vasodilation | 2008 |
Angiotensin II antagonism improves the lipoprotein profile in patients with nephrotic syndrome.
Topics: Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Apolipoprotein A-I; Apolipoproteins B; Blood Pressure; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Female; Humans; Lipoproteins; Longitudinal Studies; Losartan; Male; Middle Aged; Nephrotic Syndrome; Proteinuria; Single-Blind Method; Triglycerides | 1995 |
Efficacy and safety of losartan in treatment of hyperuricemia and posttransplantation erythrocytosis: results of a prospective, open, randomized, case-control study.
Topics: Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Case-Control Studies; Cyclosporine; Female; Humans; Hyperuricemia; Immunosuppressive Agents; Kidney Transplantation; Losartan; Male; Middle Aged; Polycythemia; Prospective Studies; Receptor, Angiotensin, Type 1; Safety; Uric Acid | 2009 |
Effects of the angiotensin II receptor blocker losartan on the monocyte expression of biglycan in hypertensive patients.
Topics: Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Biglycan; Blood Pressure; C-Reactive Protein; Female; Humans; Hypertension; Interleukin-6; Losartan; Male; Middle Aged; Monocytes; Receptors, Angiotensin; RNA, Messenger; Tumor Necrosis Factor-alpha | 2010 |
Angiotensin II, independent of plasma renin activity, contributes to the hypertension of autonomic failure.
Topics: Aged; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Captopril; Double-Blind Method; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Orthostatic Intolerance; Pure Autonomic Failure; Renin; Sodium | 2013 |
Angiotensin II blockade in kidney transplant recipients.
Topics: Adult; Albuminuria; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Double-Blind Method; Female; Fibrosis; Glomerular Filtration Rate; Humans; Kidney; Kidney Transplantation; Losartan; Male; Middle Aged; Postoperative Complications; Transplantation, Homologous; Treatment Outcome | 2013 |
Nitric oxide-angiotensin II interactions and renal hemodynamic function in patients with uncomplicated type 1 diabetes.
Topics: Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 1; Enzyme Inhibitors; Glomerular Filtration Rate; Hemodynamics; Humans; Kidney; Losartan; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Renal Circulation; Renin-Angiotensin System; Signal Transduction; Up-Regulation; Young Adult | 2013 |
Effects of exercise training on SFO-mediated sympathoexcitation during chronic heart failure.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Heart; Heart Failure; Heart Rate; Kidney; Losartan; Male; Physical Exertion; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Subfornical Organ; Sympathetic Nervous System | 2014 |
The human duodenal mucosa harbors all components for a local renin angiotensin system.
Topics: Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biphenyl Compounds; Duodenum; Female; Gastrointestinal Motility; Humans; Intestinal Mucosa; Losartan; Male; Middle Aged; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin; Renin-Angiotensin System; Tetrazoles; Young Adult | 2019 |
Angiotensin II Regulates the Neural Expression of Subjective Fear in Humans: A Precision Pharmaco-Neuroimaging Approach.
Topics: Amygdala; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Fear; Humans; Losartan; Neuroimaging | 2023 |
2179 other study(ies) available for losartan and angiotensin ii
| Article | Year |
|---|---|
Design, synthesis, and biological activities of four angiotensin II receptor ligands with gamma-turn mimetics replacing amino acid residues 3-5.
Topics: Angiotensin II; Animals; Aorta; Disulfides; In Vitro Techniques; Ligands; Magnetic Resonance Spectroscopy; Male; Models, Molecular; Molecular Structure; Muscle Contraction; Peptides, Cyclic; Pituitary Gland; Protein Conformation; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin | 1997 |
Angiotensin II analogues encompassing 5,9- and 5,10-fused thiazabicycloalkane tripeptide mimetics.
Topics: Angiotensin II; Animals; Aza Compounds; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; CHO Cells; Cricetinae; Models, Molecular; Molecular Mimicry; Oligopeptides; Protein Structure, Secondary; Radioligand Assay; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Stereoisomerism; Structure-Activity Relationship | 1999 |
Design, synthesis and biological evaluation of cyclic angiotensin II analogues with 3,5 side-chain bridges. Role of C-terminal aromatic residue and ring cluster for activity and implications in the drug design of AT1 non-peptide antagonists.
Topics: Angiotensin II; Animals; Drug Design; Models, Molecular; Peptides, Cyclic; Rabbits; Structure-Activity Relationship | 2002 |
Design, synthesis, structural studies, biological evaluation, and computational simulations of novel potent AT(1) angiotensin II receptor antagonists based on the 4-phenylquinoline structure.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta, Thoracic; Binding, Competitive; Computer Simulation; Crystallography, X-Ray; Drug Design; Imidazoles; In Vitro Techniques; Isometric Contraction; Ligands; Liver; Male; Models, Molecular; Molecular Structure; Muscle, Smooth, Vascular; Purines; Pyridines; Quinolines; Rabbits; Radioligand Assay; Rats; Rats, Wistar; Structure-Activity Relationship; Tetrazoles | 2004 |
AT2-selective angiotensin II analogues containing tyrosine-functionalized 5,5-bicyclic thiazabicycloalkane dipeptide mimetics.
Topics: Angiotensin II; Animals; Bridged Bicyclo Compounds, Heterocyclic; Crown Compounds; Dimethyl Sulfoxide; Dipeptides; Female; In Vitro Techniques; Liver; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Mimicry; Radioligand Assay; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Solutions; Structure-Activity Relationship; Swine; Tyrosine; Uterus | 2004 |
Design, synthesis, and biological evaluation of AT1 angiotensin II receptor antagonists based on the pyrazolo[3,4-b]pyridine and related heteroaromatic bicyclic systems.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Bridged Bicyclo Compounds, Heterocyclic; Caco-2 Cells; Cell Membrane Permeability; Crystallography, X-Ray; Drug Design; Humans; Intestinal Mucosa; Male; Models, Molecular; Molecular Structure; Pyrazoles; Pyridines; Rabbits; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Stereoisomerism; Structure-Activity Relationship | 2008 |
New losartan-hydrocaffeic acid hybrids as antihypertensive-antioxidant dual drugs: Ester, amide and amine linkers.
Topics: Amides; Amines; Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Aorta, Thoracic; Caffeic Acids; Cells, Cultured; Esters; Hypertension; Losartan; Male; Molecular Structure; Muscle, Smooth, Vascular; Rats; Rats, Wistar; Structure-Activity Relationship; Vasoconstrictor Agents | 2012 |
Structural determinants of subtype selectivity and functional activity of angiotensin II receptors.
Topics: Amino Acid Sequence; Angiotensin II Type 1 Receptor Blockers; Binding Sites; Ligands; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sequence Alignment | 2016 |
Mimicking of Arginine by Functionalized N(ω)-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples.
Topics: Angiotensin II; Arginine; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Ligands; Molecular Structure; Neuropeptide Y; Neurotensin; Oligopeptides; Peptide Fragments; Receptors, Angiotensin; Receptors, Neuropeptide; Receptors, Neurotensin; Structure-Activity Relationship | 2016 |
The role of the renin-angiotensin system in the control of cell communication in the heart: effects of enalapril and angiotensin II.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Bradykinin; Cell Communication; Enalapril; Heart; Imidazoles; In Vitro Techniques; Losartan; Membrane Potentials; Protein Kinase C; Protein Kinases; Rats; Renin-Angiotensin System; Tetrazoles | 1992 |
Angiotensin II receptor blockade after myocardial infarction in rats: effects on hemodynamics, myocardial DNA synthesis, and interstitial collagen content.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Cardiac Output; Collagen; DNA; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Imidazoles; Losartan; Male; Myocardial Infarction; Myocardium; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles | 1992 |
Angiotensin II receptor subtypes in rat renal preglomerular vessels.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Imidazoles; Kidney; Kidney Glomerulus; Losartan; Microcirculation; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1992 |
Angiotensin II receptor recognized by DuP753 regulates two distinct guanine nucleotide-binding protein signaling pathways.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cell Membrane; GTP-Binding Proteins; Guanosine Triphosphate; Imidazoles; Losartan; Pertussis Toxin; Phosphatidylinositols; Pituitary Gland, Anterior; Pituitary Neoplasms; Rats; Rats, Inbred BUF; Receptors, Angiotensin; Signal Transduction; Sulfhydryl Reagents; Tetrazoles; Tritium; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1992 |
Effect of DuP 753, a nonpeptide angiotensin II receptor antagonist, on the drinking responses to acutely administered dipsogenic agents in rats.
Topics: 5-Hydroxytryptophan; Analysis of Variance; Angiotensin II; Animals; Biphenyl Compounds; Captopril; Dose-Response Relationship, Drug; Drinking; Imidazoles; Injections, Intraventricular; Injections, Subcutaneous; Isoproterenol; Losartan; Male; Polyethylene Glycols; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Saline Solution, Hypertonic; Serotonin; Tetrazoles | 1992 |
Angiotensin-II inhibits Na+/K+ pump in rat adrenal glomerulosa cells: possible contribution to stimulation of aldosterone production.
Topics: Aldosterone; Angiotensin II; Animals; Biphenyl Compounds; Calcium; Enzyme Activation; Imidazoles; Ionomycin; Liver; Losartan; Ouabain; Phorbol Esters; Protein Kinase C; Rats; Rats, Inbred Strains; Rubidium; Rubidium Radioisotopes; Sodium; Sodium-Potassium-Exchanging ATPase; Tetrazoles; Zona Fasciculata; Zona Glomerulosa | 1992 |
Effect of angiotensin II on renin production by rat adrenal glomerulosa cells in culture.
Topics: Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; Biphenyl Compounds; Bucladesine; Cells, Cultured; Cyclic AMP; Female; Imidazoles; Losartan; Potassium; Rats; Rats, Inbred Strains; Renin; Tetrazoles; Zona Glomerulosa | 1992 |
DuP 753, a nonpeptide angiotensin II-1 receptor antagonist, alters dopaminergic function in rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Imidazoles; Injections, Subcutaneous; Losartan; Male; Nomifensine; Rats; Rats, Inbred Strains; Synaptic Transmission; Tetrazoles | 1992 |
Angiotensin-II acts via the type 1 receptor to inhibit 17 alpha-hydroxylase cytochrome P450 expression in ovine adrenocortical cells.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Hydrocortisone; Imidazoles; Kinetics; Losartan; Phosphoric Diester Hydrolases; Pyridines; Receptors, Angiotensin; RNA, Messenger; Sheep; Steroid 17-alpha-Hydroxylase; Tetrazoles; Zona Fasciculata; Zona Reticularis | 1992 |
A newly found angiotensin II receptor subtype mediates cyclic GMP formation in differentiated Neuro-2A cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Binding Sites; Biphenyl Compounds; Cell Differentiation; Cyclic GMP; Imidazoles; Losartan; Neuroblastoma; Pyridines; Receptors, Angiotensin; Tetrazoles; Tumor Cells, Cultured | 1992 |
Relation between inhibition of renal angiotensin II production and hemodynamic effect of captopril in anesthetized rabbit.
Topics: Angiotensin I; Angiotensin II; Animals; Biphenyl Compounds; Captopril; Dose-Response Relationship, Drug; Hemodynamics; Imidazoles; Kidney; Losartan; Male; Rabbits; Renal Circulation; Renin-Angiotensin System; Sodium, Dietary; Tetrazoles | 1992 |
Angiotensin II receptor antagonist delays renal damage and stroke in salt-loaded Dahl salt-sensitive rats.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Cerebrovascular Disorders; Hypertension; Imidazoles; Kidney Diseases; Losartan; Male; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Sodium, Dietary; Survival Analysis; Tetrazoles | 1992 |
Effects of angiotensin II and nonpeptide receptor antagonists on transduction pathways in rat proximal tubule.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Calcium; Cyclic AMP; Imidazoles; Inositol Phosphates; Kidney Tubules, Proximal; Losartan; Male; Osmolar Concentration; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetrazoles | 1992 |
Angiotensin dependence of endothelium-mediated renal hemodynamics.
Topics: Angiotensin II; Animals; Arginine; Biphenyl Compounds; Blood Pressure; Enalaprilat; Endothelium, Vascular; Hemodynamics; Imidazoles; Kinins; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Circulation; Tetrazoles | 1992 |
EDRF-angiotensin II interactions in rat juxtamedullary afferent and efferent arterioles.
Topics: Acetylcholine; Angiotensin II; Animals; Arginine; Arterioles; Biphenyl Compounds; Drug Interactions; Enalaprilat; Imidazoles; In Vitro Techniques; Kidney Medulla; Losartan; Male; Nitric Oxide; Nitroarginine; Osmolar Concentration; Rats; Renal Circulation; Tetrazoles; Vasoconstriction | 1992 |
Effects of angiotensin II and its selective antagonists on inferior olivary neurones.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Biphenyl Compounds; Imidazoles; Losartan; Neurons; Oligopeptides; Olivary Nucleus; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Synaptic Transmission; Tetrazoles | 1992 |
Cytoskeleton-dependent endocytosis is required for apical type 1 angiotensin II receptor-mediated phospholipase C activation in cultured rat proximal tubule cells.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Biphenyl Compounds; Cell Polarity; Cells, Cultured; Cyclic AMP; Cytochalasin D; Cytoskeleton; Endocytosis; Enzyme Activation; Imidazoles; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kidney Tubules, Proximal; Losartan; Male; Microscopy, Electron; Parathyroid Hormone; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Sodium; Tetrazoles; Type C Phospholipases | 1992 |
Effects of the angiotensin II receptor antagonist Losartan (DuP 753/MK 954) on arterial blood pressure, heart rate, plasma concentrations of angiotensin II and renin and the pressor response to infused angiotensin II in the salt-deplete dog.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Losartan; Male; Pressoreceptors; Renin; Renin-Angiotensin System; Sodium Chloride; Tetrazoles | 1992 |
Angiotensin II increases proto-oncogene expression and phosphoinositide turnover in vascular smooth muscle cells via the angiotensin II AT1 receptor.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cells, Cultured; Gene Expression Regulation; Genes, fos; Imidazoles; Losartan; Muscle, Smooth, Vascular; Phosphatidylinositols; Pyridines; Rats; Receptors, Angiotensin; Tetrazoles | 1992 |
Role of angiotensin II receptor subtypes on the regulation of aldosterone secretion in the adrenal glomerulosa zone in the rat.
Topics: Aldosterone; Angiotensin II; Animals; Biphenyl Compounds; Cells, Cultured; Cyclic AMP; Dithiothreitol; Imidazoles; Inositol Phosphates; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Secretory Rate; Signal Transduction; Sodium, Dietary; Tetrazoles; Zona Glomerulosa | 1992 |
[New antihypertensive drugs on various phases of study].
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amino Acids; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Biphenyl Compounds; Diuretics; Humans; Imidazoles; Losartan; Peptides, Cyclic; Receptors, Cell Surface; Receptors, Endothelin; Sulfhydryl Compounds; Tetrazoles | 1992 |
Antianxiety properties of the angiotensin II antagonist, DUP 753, in the rat using the elevated plus-maze.
Topics: Angiotensin II; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Biphenyl Compounds; Blood Pressure; Diazepam; Imidazoles; Losartan; Male; Rats; Rats, Sprague-Dawley; Tetrazoles | 1992 |
Angiotensin II receptor-mediated calcium influx in bovine adrenal glomerulosa cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Calcium; Calcium Channels; Cattle; Cells, Cultured; Dihydropyridines; GTP-Binding Proteins; Imidazoles; Lanthanum; Losartan; Pertussis Toxin; Receptors, Angiotensin; Tetrazoles; Virulence Factors, Bordetella; Zona Glomerulosa | 1992 |
Effects of losartan, a nonpeptide angiotensin II receptor antagonist, on cardiac hypertrophy and the tissue angiotensin II content in spontaneously hypertensive rats.
Topics: Analysis of Variance; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Body Weight; Cardiomegaly; Heart Rate; Heart Ventricles; Hypertension; Imidazoles; Losartan; Male; Organ Size; Radioimmunoassay; Rats; Rats, Inbred SHR; Renin; Tetrazoles | 1992 |
Long-term angiotensin II antagonism in spontaneously hypertensive rats: effects on blood pressure and cardiovascular amplifiers.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Cardiomegaly; Cardiovascular Agents; Cardiovascular Physiological Phenomena; Cardiovascular System; Hindlimb; Hypertension; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazoles; Time Factors | 1992 |
Evidence that the apparent complexity of receptor antagonism by angiotensin II analogues is due to a reversible and syntopic action.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Behavior, Animal; Biphenyl Compounds; Guinea Pigs; Ileum; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle, Smooth; Rabbits; Stomach; Tetrazoles | 1992 |
Possible implication of peptidase activity in different potency of angiotensins II and III for displacing [125I]angiotensin II binding in pig aorta.
Topics: Aminopeptidases; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Aorta; Binding, Competitive; Biphenyl Compounds; Calcium; Cells, Cultured; Endopeptidases; Imidazoles; In Vitro Techniques; Iodine Radioisotopes; Losartan; Membranes; Muscle, Smooth, Vascular; Pyridines; Swine; Tetrazoles | 1992 |
Antihypertensive and hormonal activity of MK 954 in spontaneously hypertensive rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Hormones; Hypertension; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin; Renin-Angiotensin System; Tetrazoles | 1992 |
Losartan potassium, a nonpeptide antagonist of angiotensin II, chronically administered p.o. does not readily cross the blood-brain barrier.
Topics: Administration, Oral; Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Blood-Brain Barrier; Drinking; Imidazoles; Injections, Intraventricular; Losartan; Rats; Tetrazoles | 1992 |
Angiotensin II does not increase renal prostaglandin E2 in response to pressure reduction.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Dinoprostone; Dogs; Female; Imidazoles; Infusions, Intra-Arterial; Kidney; Losartan; Male; Renal Circulation; Renin; Saralasin; Tetrazoles | 1992 |
Stimulation of prolactin secretion from rat pituitary by luteinizing hormone-releasing hormone: evidence against mediation by angiotensin II acting through a (Sar1-Ala8)-angiotensin II-sensitive receptor.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Animals; Biphenyl Compounds; Captopril; Cells, Cultured; Female; Gonadotropin-Releasing Hormone; Imidazoles; Losartan; Male; Pituitary Gland; Prolactin; Rats; Rats, Wistar; Receptors, Angiotensin; Saralasin; Tetrazoles | 1992 |
Angiotensin II receptor subtypes in cultured rat renal mesangial cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding Sites; Biphenyl Compounds; Cells, Cultured; Glomerular Mesangium; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Imidazoles; Losartan; Pertussis Toxin; Pyridines; Rats; Receptors, Angiotensin; Tetrazoles; Virulence Factors, Bordetella | 1992 |
AT1 receptors mediate the release of prostaglandins in porcine smooth muscle cells and rat astrocytes.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arachidonic Acids; Astrocytes; Biphenyl Compounds; Calcimycin; Cattle; Cells, Cultured; Dinoprost; Dose-Response Relationship, Drug; Endothelium, Vascular; Epoprostenol; Glioma; Imidazoles; Iodine Radioisotopes; Losartan; Macrophages; Male; Muscle, Smooth, Vascular; Prostaglandins; Pyridines; Radioimmunoassay; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Swine; Tetrazoles; Thromboxanes; Tumor Cells, Cultured | 1992 |
Intracerebroventricular angiotensin II-induced thirst and sodium appetite in rat are blocked by the AT1 receptor antagonist, Losartan (DuP 753), but not by the AT2 antagonist, CGP 42112B.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Appetite; Biphenyl Compounds; Imidazoles; Injections, Intraventricular; Losartan; Male; Oligopeptides; Rats; Rats, Wistar; Sodium, Dietary; Tetrazoles; Thirst | 1992 |
Competitive antagonism of pressor responses to angiotensin II and angiotensin III by the angiotensin II-1 receptor ligand losartan.
Topics: Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Tetrazoles | 1992 |
Enhancement of losartan (DuP 753)-induced angiotensin II receptor antagonism by PD123177 in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Decerebrate State; Hypertension, Renal; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Tetrazoles | 1992 |
Losartan inhibits the angiotensin II-induced stimulation of the phosphoinositide signalling system in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Aorta; Biphenyl Compounds; Calcium; Cell Division; Cells, Cultured; Imidazoles; Inositol 1,4,5-Trisphosphate; Losartan; Muscle, Smooth, Vascular; Rats; Rats, Inbred WKY; Signal Transduction; Tetrazoles | 1992 |
Effect of captopril and the nonpeptide angiotensin II antagonists, SK&F 108566 and EXP3174, on renal function in dogs with a renal artery stenosis.
Topics: Acrylates; Angiotensin II; Animals; Blood Pressure; Captopril; Dogs; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; Imidazoles; Inulin; Kidney; Losartan; Regional Blood Flow; Renal Artery Obstruction; Tetrazoles; Thiophenes | 1992 |
Discovery of a novel class of orally active, non-peptide angiotensin II antagonists.
Topics: Administration, Oral; Angiotensin II; Animals; Biphenyl Compounds; Imidazoles; Losartan; Pyrimidines; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Structure-Activity Relationship; Tetrazoles | 1992 |
[125I]EXP985: a highly potent and specific nonpeptide radioligand antagonist for the AT1 angiotensin receptor.
Topics: Adrenal Cortex; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Biphenyl Compounds; Dose-Response Relationship, Drug; Imidazoles; Iodine Radioisotopes; Ligands; Losartan; Microsomes; Muscle, Smooth, Vascular; Rats; Tetrazoles | 1992 |
Role of angiotensin subtype 2 receptor in neointima formation after vascular injury.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Carotid Arteries; Carotid Artery Injuries; Catheterization; Hyperplasia; Imidazoles; Indoles; Losartan; Male; Oligopeptides; Perindopril; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles; Tunica Intima | 1992 |
Blocking hypothalamic AT1 receptors lowers blood pressure in salt-sensitive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anterior Hypothalamic Nucleus; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Diet; Heart Rate; Imidazoles; Losartan; Microinjections; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium Chloride; Tetrazoles | 1992 |
The role of endogenous angiotensin II in the regulation of renal haemodynamics and proximal fluid reabsorption in the rat.
Topics: Absorption; Angiotensin II; Animals; Biphenyl Compounds; Glomerular Filtration Rate; Hemodynamics; Imidazoles; Kidney; Kidney Tubules; Losartan; Male; Rats; Rats, Sprague-Dawley; Tetrazoles | 1992 |
Pharmacological profile of GR117289 in vitro: a novel, potent and specific non-peptide angiotensin AT1 receptor antagonist.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Binding Sites; Biphenyl Compounds; Cattle; Cerebellum; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Liver; Losartan; Muscle Contraction; Muscle, Smooth, Vascular; Nicotinic Acids; Rabbits; Radioligand Assay; Receptors, Angiotensin; Tetrazoles; Vasoconstriction | 1992 |
Effects of Losartan, a nonpeptide angiotensin II receptor antagonist, on norepinephrine overflow and antidiuresis induced by stimulation of renal nerves in anesthetized dogs.
Topics: Anesthesia; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Diuresis; Dogs; Electric Stimulation; Female; Hemodynamics; Imidazoles; Kidney; Losartan; Male; Norepinephrine; Receptors, Angiotensin; Sympathetic Nervous System; Tetrazoles | 1992 |
Dihydropyrimidine angiotensin II receptor antagonists.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Imidazoles; Losartan; Male; Pyrimidines; Rats; Rats, Inbred SHR; Structure-Activity Relationship; Tetrazoles | 1992 |
Effect of losartan potassium and deoxycorticosterone acetate on tail skin temperature response to acute administration of angiotensin II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Body Temperature; Desoxycorticosterone; Imidazoles; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Saralasin; Skin Temperature; Tail; Tetrazoles | 1992 |
Characterization of glomerular angiotensin II receptor subtypes.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Imidazoles; In Vitro Techniques; Kidney Glomerulus; Kinetics; Losartan; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1992 |
Inhibition of the haemodynamic effects of angiotensin II in conscious rats by AT2-receptor antagonists given after the AT1-receptor antagonist, EXP 3174.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Hemodynamics; Imidazoles; Losartan; Male; Pyridines; Rats; Regional Blood Flow; Tetrazoles | 1992 |
Inhibitory effects of DuP 753 and EXP3174 on responses to angiotensin II in pulmonary vascular bed of the cat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Gas Analysis; Cats; Endothelins; Female; Hydrogen-Ion Concentration; Imidazoles; Losartan; Male; Norepinephrine; Pulmonary Circulation; Serotonin; Tetrazoles; Vasopressins | 1992 |
Angiotensin II is retained in gonadotrophs of pituitary cell aggregates cultured in serum-free medium but does not mimic the effects of exogenous angiotensins and luteinizing-hormone-releasing hormone on growth hormone release.
Topics: Angiotensin II; Angiotensins; Animals; Biphenyl Compounds; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media, Serum-Free; Female; Gonadotropin-Releasing Hormone; Growth Hormone; Imidazoles; Immunohistochemistry; Losartan; Pituitary Gland, Anterior; Radioimmunoassay; Rats; Rats, Wistar; Saralasin; Tetrazoles | 1992 |
Angiotensin II receptor activation depolarizes rat supraoptic neurons in vitro.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Culture Media; Electrophysiology; Imidazoles; Losartan; Male; Neurons; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Supraoptic Nucleus; Tetrazoles; Tetrodotoxin | 1992 |
The antihypertensive effect of the angiotensin II receptor antagonist DuP 753 may not be due solely to angiotensin II receptor antagonism.
Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Captopril; Decerebrate State; Enalapril; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Receptors, Angiotensin; Spinal Cord; Tetrazoles; Thiophenes | 1992 |
Modulation of net outward current in cultured neurons by angiotensin II: involvement of AT1 and AT2 receptors.
Topics: Action Potentials; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Brain Stem; Cells, Cultured; Hypothalamus; Imidazoles; Losartan; Membrane Potentials; Neurons; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles | 1992 |
Mechanism of angiotensin II-induced proliferation in bovine adrenocortical cells.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adrenal Cortex; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Cell Division; Cells, Cultured; DNA Replication; Dose-Response Relationship, Drug; Flavanones; Flavonoids; Humans; Hydroxyeicosatetraenoic Acids; Imidazoles; Losartan; Protein Kinase C; Pyrazoles; Pyridines; Pyrimidine Nucleosides; Tetrazoles; Thymidine | 1992 |
Characterization and distribution of angiotensin II binding sites in fetal and neonatal astrocytes from different rat brain regions.
Topics: Angiotensin II; Animals; Animals, Newborn; Astrocytes; Binding Sites; Binding, Competitive; Biphenyl Compounds; Brain; Cells, Cultured; Fetus; Imidazoles; Losartan; Oligopeptides; Rats; Saralasin; Tetrazoles; Tissue Distribution | 1992 |
Effects of a non-peptide angiotensin receptor antagonist on drinking and blood pressure responses to centrally administered angiotensins in the rat.
Topics: Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Cerebral Ventricles; Drinking Behavior; Imidazoles; Injections, Intraventricular; Losartan; Male; Rats; Rats, Inbred Strains; Reference Values; Tetrazoles; Time Factors | 1992 |
Angiotensin II and active phorbol esters induce proto-oncogene expression in isolated rat hepatocytes.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cycloheximide; Dactinomycin; Female; Gene Expression Regulation; Imidazoles; Liver; Losartan; Phorbol Esters; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles | 1992 |
The role of angiotensin, AT1 and AT2 receptors in the pressor, drinking and vasopressin responses to central angiotensin.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Arginine Vasopressin; Biphenyl Compounds; Blood Pressure; Cerebral Ventricles; Drinking Behavior; Imidazoles; Injections, Intraventricular; Losartan; Male; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles | 1992 |
Angiotensin II receptor blockade limits glomerular injury in rats with reduced renal mass.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Creatinine; Glomerular Filtration Rate; Imidazoles; Kidney Glomerulus; Losartan; Male; Nephrectomy; Proteinuria; Punctures; Rats; Rats, Inbred Strains; Tetrazoles | 1992 |
Renal-specific actions of angiotensin II receptor antagonism in the anesthetized dog.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cardiovascular System; Diuresis; Dogs; Hemodynamics; Imidazoles; Infusions, Intravenous; Kidney; Losartan; Male; Natriuresis; Osmolar Concentration; Pharmaceutical Vehicles; Renal Circulation; Tetrazoles | 1992 |
Renal hemodynamic and excretory responses to PD 123319 and losartan, nonpeptide AT1 and AT2 subtype-specific angiotensin II ligands.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Dogs; Female; Glomerular Filtration Rate; Hemodynamics; Imidazoles; Kidney; Losartan; Male; Pyridines; Renal Circulation; Saralasin; Tetrazoles | 1992 |
Angiotensin II and monocrotaline-induced pulmonary hypertension: effect of losartan (DuP 753), a nonpeptide angiotensin type 1 receptor antagonist.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Body Weight; Hypertension, Pulmonary; Imidazoles; Losartan; Male; Monocrotaline; Pressoreceptors; Rats; Rats, Inbred Strains; Renin; Tetrazoles | 1992 |
Kinins mediate the antiproliferative effect of ramipril in rat carotid artery.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Bradykinin; Bridged Bicyclo Compounds; Carotid Arteries; Carotid Artery Injuries; Endothelium, Vascular; Imidazoles; Kinins; Losartan; Male; Muscle, Smooth, Vascular; Oligopeptides; Ramipril; Rats; Rats, Inbred Strains; Tetrazoles | 1992 |
Angiotensin II stimulation of left ventricular hypertrophy in adult rat heart. Mediation by the AT1 receptor.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Cardiomegaly; Imidazoles; Infusion Pumps; Losartan; Male; Organ Size; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles | 1992 |
Distribution of angiotensin II receptor subtypes in rat and human kidney.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding, Competitive; Biphenyl Compounds; Humans; Imidazoles; Kidney; Losartan; Male; Pyridines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles; Tissue Distribution | 1992 |
Regulation of the expression of the rat angiotensin II receptor mRNA.
Topics: Actins; Adrenal Glands; Angiotensin II; Animals; Aorta; Biphenyl Compounds; Brain Stem; Cell Line; Chromosome Deletion; Gene Expression Regulation; Imidazoles; Kidney; Losartan; Muscle, Smooth, Vascular; Nephrectomy; Organ Specificity; Polymerase Chain Reaction; Rats; Receptors, Angiotensin; RNA, Messenger; Tetrazoles | 1992 |
Characterization of renal angiotensin II receptors using subtype selective antagonists.
Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Biphenyl Compounds; Dithiothreitol; Guanylyl Imidodiphosphate; Imidazoles; In Vitro Techniques; Kidney; Losartan; Oligopeptides; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles; Thiophenes | 1992 |
Nitric oxide and angiotensin II. Glomerular and tubular interaction in the rat.
Topics: Angiotensin II; Animals; Arginine; Biphenyl Compounds; Glomerular Filtration Rate; Glycine; Imidazoles; Kidney Glomerulus; Kidney Tubules; Losartan; Male; Nitric Oxide; omega-N-Methylarginine; Rats; Rats, Inbred Strains; Saralasin; Tetrazoles | 1992 |
AT1 angiotensin receptors mobilize intracellular calcium in a subclone of NG108-15 neuroblastoma cells.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Calcium; Imidazoles; Intracellular Membranes; Losartan; Neuroblastoma; Receptors, Angiotensin; Tetrazoles; Tumor Cells, Cultured | 1992 |
Depressor effect of blocking angiotensin subtype 1 receptors in anterior hypothalamus.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Body Weight; Hypertension; Hypothalamus, Anterior; Imidazoles; Losartan; Microinjections; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Tetrazoles | 1992 |
Modulation of angiotensin II binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the DuP-753-sensitive angiotensin II receptor of bovine adrenal glomerulosa.
Topics: Allosteric Regulation; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cattle; Cells, Cultured; Imidazoles; Losartan; Microsomes; Polyvinyls; Pyridines; Receptors, Angiotensin; Signal Transduction; Substrate Specificity; Tetrazoles; Zona Glomerulosa | 1992 |
Mapping of angiotensin II receptor subtype heterogeneity in rat brain.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding, Competitive; Biphenyl Compounds; Brain; Brain Mapping; Dithiothreitol; Imidazoles; Iodine Radioisotopes; Losartan; Male; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles | 1992 |
Analysis of angiotensin II receptor subtypes in individual rat brain nuclei.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding, Competitive; Biphenyl Compounds; Brain Chemistry; Imidazoles; Losartan; Male; Mercaptoethanol; Pituitary Gland, Anterior; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles | 1992 |
[Antihypertensive effect of a non-peptide angiotensin II receptor antagonist, MK954, in patients with essential hypertension].
Topics: Adult; Aged; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Female; Humans; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Tetrazoles | 1992 |
Central DuP 753 does not lower blood pressure in spontaneously hypertensive rats.
Topics: Administration, Oral; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Brain; Imidazoles; Injections, Intraventricular; Losartan; Male; Rats; Rats, Inbred SHR; Tetrazoles | 1992 |
Angiotensin II and renal functional reserve in rats with Goldblatt hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Captopril; Glycine; Hemodynamics; Hypertension, Renovascular; Imidazoles; Injections; Kidney; Kidney Glomerulus; Losartan; Male; Punctures; Rats; Rats, Inbred Strains; Tetrazoles | 1992 |
Losartan, a specific angiotensin II receptor antagonist, increases angiotensin I and angiotensin II release from isolated rat hind legs: evidence for locally regulated renin-angiotensin system in vascular tissue.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Vessels; Hindlimb; Imidazoles; Losartan; Male; Muscle, Smooth, Vascular; Nephrectomy; Perfusion; Rats; Renin-Angiotensin System; Tetrazoles; Time Factors | 1992 |
Simultaneous determination of a novel angiotensin II receptor blocking agent, losartan, and its metabolite in human plasma and urine by high-performance liquid chromatography.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Chromatography, High Pressure Liquid; Humans; Imidazoles; Losartan; Reproducibility of Results; Spectrophotometry, Ultraviolet; Tetrazoles | 1992 |
In vitro pharmacology of a nonpeptidic angiotensin II receptor antagonist, SC-51316.
Topics: Adrenal Cortex; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cell Membrane; Female; Imidazoles; Kidney; Losartan; Muscle, Smooth, Vascular; Rats; Receptors, Angiotensin; Renin; Tetrazoles; Triazoles; Uterus | 1992 |
Cardiac angiotensin receptors: effects of selective angiotensin II receptor antagonists, DUP 753 and PD 121981, in rabbit heart.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding Sites; Biphenyl Compounds; Imidazoles; Losartan; Myocardial Contraction; Myocardium; Pyridines; Rabbits; Receptors, Angiotensin; Tetrazoles | 1992 |
Different types of receptor interaction of peptide and nonpeptide angiotensin II antagonists revealed by receptor binding and functional studies.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Binding Sites; Biphenyl Compounds; Female; Imidazoles; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Losartan; Male; Muscle Contraction; Peptides; Rabbits; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles | 1992 |
Drinking induced by subcutaneous injection of angiotensin II in the rat is blocked by the selective AT1 receptor antagonist DuP 753 but not by the selective AT2 receptor antagonist WL 19.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Drinking; Imidazoles; Injections, Subcutaneous; Losartan; Male; Pyridines; Rats; Rats, Inbred Strains; Tetrazoles | 1992 |
In vitro pharmacology of L-158,809, a new highly potent and selective angiotensin II receptor antagonist.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Binding, Competitive; Biphenyl Compounds; Brain; Cell Membrane; Culture Techniques; Humans; Imidazoles; Losartan; Macaca mulatta; Muscle, Smooth, Vascular; Rabbits; Rats; Species Specificity; Tetrazoles | 1992 |
In vivo pharmacology of L-158,809, a new highly potent and selective nonpeptide angiotensin II receptor antagonist.
Topics: Administration, Oral; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Female; Imidazoles; Injections, Intravenous; Losartan; Macaca mulatta; Male; Pressoreceptors; Pyridines; Rats; Rats, Inbred Strains; Tetrazoles | 1992 |
Pharmacological characterization of angiotensin-induced depolarizations of rat superior cervical ganglion in vitro.
Topics: Angiotensin II; Angiotensin III; Animals; Anti-Bacterial Agents; Bacitracin; Biphenyl Compounds; Dithiothreitol; Ganglia, Sympathetic; Imidazoles; In Vitro Techniques; Losartan; Male; Neuromuscular Depolarizing Agents; Oligopeptides; Peptides; Protease Inhibitors; Rats; Tetrazoles | 1992 |
Angiotensin II receptor subtypes play opposite roles in regulating phosphatidylinositol hydrolysis in rat skin slices.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Chromatography, High Pressure Liquid; Hydrolysis; Imidazoles; In Vitro Techniques; Inositol Phosphates; Kinetics; Losartan; Male; Phosphatidylinositols; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Skin; Tetrazoles | 1992 |
Monoclonal antibodies to the nonpeptide angiotensin II receptor antagonist, losartan.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antibodies, Monoclonal; Antibody Specificity; Biphenyl Compounds; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Imidazoles; Losartan; Mice; Mice, Inbred BALB C; Pyridines; Saralasin; Structure-Activity Relationship; Tetrazoles | 1992 |
Effect of an angiotensin II and a kinin receptor antagonist on the renal hemodynamic response to captopril.
Topics: Angiotensin II; Animals; Bradykinin; Captopril; Hemodynamics; Imidazoles; Kinins; Lasers; Losartan; Punctures; Rats; Rats, Inbred Strains; Receptors, Bradykinin; Receptors, Neurotransmitter; Renal Circulation; Tetrazoles; Ultrasonography | 1991 |
Angiotensin-II receptor subtypes in fetal tissue of the rat: autoradiography, guanine nucleotide sensitivity, and association with phosphoinositide hydrolysis.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding, Competitive; Fetus; Gestational Age; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Imidazoles; Losartan; Oligopeptides; Phosphatidylinositols; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles; Tissue Distribution | 1991 |
Further studies on the selectivity of DuP 753, a nonpeptide angiotensin II receptor antagonist.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Brain; Guinea Pigs; Ileum; Imidazoles; In Vitro Techniques; Kinetics; Losartan; Muscle Contraction; Rats; Receptors, Angiotensin; Receptors, Cell Surface; Tetrazoles | 1991 |
Angiotensin II receptor subtypes in renal cortex of rats and rhesus monkeys.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding, Competitive; Biphenyl Compounds; Blood Pressure; Enalaprilat; Heart Rate; Imidazoles; Iodine Radioisotopes; Kidney Cortex; Losartan; Macaca mulatta; Male; Pyridines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Renin; Tetrazoles | 1991 |
Angiotensin II receptor subtypes and biological responses in the adrenal cortex and medulla.
Topics: Adrenal Cortex; Adrenal Medulla; Aldosterone; Angiotensin II; Animals; Binding Sites; Biphenyl Compounds; Cattle; Cyclic AMP; Imidazoles; In Vitro Techniques; Losartan; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles; Zona Glomerulosa | 1991 |
Angiotensin-II activation of cAMP and corticosterone production in bovine adrenocortical cells: effects of nonpeptide angiotensin-II antagonists.
Topics: Adrenal Cortex; Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Cattle; Corticosterone; Cyclic AMP; Imidazoles; Losartan; Pyridines; Saralasin; Tetrazoles | 1991 |
Presynaptic modulation of neurotransmitter release by endogenous angiotensin II in brown adipose tissue.
Topics: Adipose Tissue, Brown; Analysis of Variance; Angiotensin II; Animals; Biological Transport; Biphenyl Compounds; Electric Stimulation; Imidazoles; In Vitro Techniques; Kinetics; Losartan; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Synaptic Transmission; Tetrazoles | 1991 |
DuP 753 is a specific antagonist for the angiotensin receptor.
Topics: Adrenergic alpha-Antagonists; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Vessels; Digestive System; Humans; Imidazoles; In Vitro Techniques; Kinetics; Kinins; Losartan; Male; Muscarinic Antagonists; Rabbits; Rats; Rats, Inbred Strains; Tetrazoles; Urinary Bladder | 1991 |
Binding characteristics and vascular effects of various angiotensin II antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensins; Animals; Aorta; Biphenyl Compounds; Dose-Response Relationship, Drug; Female; Humans; Imidazoles; In Vitro Techniques; Ligands; Losartan; Muscle, Smooth, Vascular; Oligopeptides; Rabbits; Rats; Receptors, Angiotensin; Saralasin; Uterus | 1990 |
Comparison of the acute hypotensive effects of renin inhibition, converting enzyme inhibition, and angiotensin II antagonism in rats.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Analysis of Variance; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Enalaprilat; Hypertension; Hypertension, Renal; Imidazoles; Losartan; Oligopeptides; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Renin; Time Factors | 1990 |
Characterization of distinct angiotensin II binding sites in rat adrenal gland and bovine cerebellum using selective nonpeptide antagonists.
Topics: Adrenal Glands; Adrenal Medulla; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Cattle; Cerebellum; Imidazoles; In Vitro Techniques; Kinetics; Losartan; Male; Peptides; Pyridines; Rabbits; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles; Vasoconstriction; Zona Glomerulosa | 1991 |
Type-1 and type-2 angiotensin II receptors in fetal rat brain.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Biphenyl Compounds; Brain; Female; Fetus; Imidazoles; Iodine Radioisotopes; Losartan; Oligopeptides; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Staining and Labeling; Tetrazoles | 1991 |
Angiotensin II and left ventricular growth in newborn pig heart.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Biphenyl Compounds; DNA; Enalapril; Heart Ventricles; Imidazoles; Losartan; Proteins; RNA; Swine; Tetrazoles | 1991 |
Effects of angiotensin on renal cortical and papillary blood flows measured by laser-Doppler flowmetry.
Topics: Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Aorta; Aprotinin; Biphenyl Compounds; Blood Flow Velocity; Blood Pressure; Constriction; Dose-Response Relationship, Drug; Imidazoles; Indomethacin; Kidney Cortex; Kidney Medulla; Lasers; Losartan; Male; Rats; Rats, Inbred WKY; Tetrazoles | 1991 |
In vivo evaluation of the antagonist activity of angiotensin I analogs.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensins; Animals; Biphenyl Compounds; Captopril; Imidazoles; Losartan; Lung; Male; Peptide Fragments; Rats; Rats, Inbred Strains; Tetrazoles | 1992 |
Stimulation of endothelial cell prostaglandin production by angiotensin peptides. Characterization of receptors.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cells, Cultured; Dinoprostone; Endothelium, Vascular; Epoprostenol; Imidazoles; Losartan; Oligopeptides; Prostaglandins; Pyridines; Receptors, Angiotensin; Tetrazoles | 1992 |
Effects of angiotensin subtype 1 and subtype 2 receptor antagonists in normotensive versus hypertensive rats.
Topics: Aldosterone; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Hypertension; Imidazoles; Infusions, Intravenous; Losartan; Mesentery; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Receptors, Angiotensin; Tetrazoles; Vasoconstriction | 1991 |
Losartan, a nonpeptide angiotensin II (Ang II) receptor antagonist, inhibits neointima formation following balloon injury to rat carotid arteries.
Topics: Analysis of Variance; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Carotid Arteries; Carotid Artery Injuries; Catheterization; Dose-Response Relationship, Drug; Imidazoles; Losartan; Male; Rats; Rats, Inbred Strains; Tetrazoles | 1991 |
Nonpeptide angiotensin II receptor antagonists. Studies with DuP 753 and EXP3174 in dogs.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Captopril; Dogs; Female; Furosemide; Imidazoles; Kidney; Kidney Function Tests; Losartan; Male; Pyridines; Radioimmunoassay; Renin-Angiotensin System; Tetrazoles | 1991 |
Angiotensin-converting enzyme inhibitor versus angiotensin II, AT1 receptor antagonist. Effects on smooth muscle cell migration and proliferation after balloon catheter injury.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Biphenyl Compounds; Blood Pressure; Catheterization; Cell Division; Cell Movement; Imidazoles; Losartan; Male; Muscle, Smooth, Vascular; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Tetrazoles | 1991 |
Identification of angiotensin II receptor subtypes in human brain.
Topics: Aged; Angiotensin II; Angiotensin Receptor Antagonists; Autoradiography; Binding, Competitive; Biphenyl Compounds; Cerebellum; Female; Humans; Imidazoles; Iodine Radioisotopes; Losartan; Male; Pyridines; Receptors, Angiotensin; Tetrazoles | 1991 |
The AT2 angiotensin receptor subtype predominates in the 18 day gestation fetal rat brain.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding Sites; Biphenyl Compounds; Brain; Densitometry; Fetus; Imidazoles; Losartan; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Tetrazoles | 1991 |
Distribution of angiotensin II receptor subtypes in rat brain nuclei.
Topics: Angiotensin II; Animals; Binding, Competitive; Biphenyl Compounds; Brain; Brain Stem; Hypothalamus; Imidazoles; Iodine Radioisotopes; Losartan; Male; Mesencephalon; Oligopeptides; Organ Specificity; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Saralasin; Tetrazoles | 1991 |
Access of peripherally administered DuP 753 to rat brain angiotensin II receptors.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Biphenyl Compounds; Brain Chemistry; Imidazoles; Iodine Radioisotopes; Losartan; Male; Medulla Oblongata; Rats; Rats, Inbred Strains; Tetrazoles | 1991 |
Effect of the angiotensin antagonist DuP 753 on the renal adaptation to sodium restriction in the rat.
Topics: Adaptation, Physiological; Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Diet, Sodium-Restricted; Imidazoles; Kidney; Losartan; Natriuresis; Rats; Rats, Inbred Strains; Tetrazoles | 1991 |
Characterization of angiotensin II receptor subtypes in the rat kidney and heart using the non-peptide antagonists DuP 753 and PD 123 177.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Imidazoles; Kidney; Losartan; Male; Myocardium; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles | 1991 |
Effect of the angiotensin II receptor antagonist MK 954 on the angiotensin II-induced increase in free cytosolic Ca2+ and growth in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Calcium; Cells, Cultured; Cytosol; Imidazoles; Losartan; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Proteins; Rats; Rats, Inbred WKY; Tetrazoles | 1991 |
Role of angiotensin II in injury-induced neointima formation in rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Carotid Arteries; Cell Division; Cilazapril; Endothelium, Vascular; Imidazoles; Losartan; Male; Pyridazines; Rats; Regeneration; Tetrazoles | 1991 |
Role of angiotensin II receptor antagonism and converting enzyme inhibition in the progression and regression of cardiac hypertrophy in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Abdominal; Biphenyl Compounds; Bridged Bicyclo Compounds; Cardiomegaly; Constriction; Hypertension; Imidazoles; Losartan; Male; Ramipril; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles | 1991 |
Angiotensin II-1 receptors mediate both vasoconstrictor and hypertrophic responses in rat aortic smooth muscle cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Biphenyl Compounds; Cells, Cultured; DNA; Fluorescent Dyes; Fura-2; Hypertrophy; Imidazoles; Losartan; Male; Muscle Proteins; Muscle, Smooth, Vascular; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles; Vasoconstriction | 1991 |
Kinin contribution to renal vasodilator effect of captopril in rabbit.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Bradykinin; Captopril; Imidazoles; Kidney; Losartan; Rabbits; Receptors, Bradykinin; Receptors, Neurotransmitter; Renal Circulation; Saralasin; Tetrazoles; Vasodilation | 1991 |
The influence of glucose concentration on angiotensin II-induced hypertrophy of proximal tubular cells in culture.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cell Line; Cyclic AMP; Glucose; Hypertrophy; Imidazoles; Kidney Tubules, Proximal; Losartan; Receptors, Angiotensin; Tetrazoles | 1991 |
Characterization of the renal microvascular effects of angiotensin II antagonist, DuP 753: studies in isolated perfused hydronephrotic kidneys.
Topics: Angiotensin II; Animals; Arterioles; Hydronephrosis; Imidazoles; In Vitro Techniques; Losartan; Male; Microcirculation; Perfusion; Rats; Rats, Inbred Strains; Renal Circulation; Tetrazoles | 1991 |
Effects of DuP 753 on proximal nephron and renal transport.
Topics: Angiotensin II; Animals; Biological Transport; Body Fluids; Captopril; Electrolytes; Imidazoles; Kidney; Kidney Tubules; Losartan; Male; Nephrons; Perfusion; Punctures; Rats; Rats, Inbred Strains; Tetrazoles | 1991 |
Hemodynamic effects of direct angiotensin II blockade compared to converting enzyme inhibition in rat model of heart failure.
Topics: Administration, Oral; Angiotensin II; Animals; Body Weight; Captopril; Cardiac Output, Low; Compliance; Disease Models, Animal; Dose-Response Relationship, Drug; Heart; Hemodynamics; Imidazoles; Losartan; Male; Myocardial Infarction; Rats; Rats, Inbred Strains; Tetrazoles; Ventricular Function, Left | 1991 |
Angiotensin II receptor subtypes in rat brain: dithiothreitol inhibits ligand binding to AII-1 and enhances binding to AII-2.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Brain Chemistry; Dithiothreitol; Imidazoles; In Vitro Techniques; Iodine Radioisotopes; Losartan; Male; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Saralasin; Tetrazoles | 1991 |
Characterization and development of angiotensin II receptor subtypes (AT1 and AT2) in rat brain.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding, Competitive; Brain; Imidazoles; Losartan; Male; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles; Tissue Distribution | 1991 |
Haemodynamic effects of human alpha-calcitonin gene-related peptide following administration of endothelin-1 or NG-nitro-L-arginine methyl ester in conscious rats.
Topics: Angiotensin II; Animals; Arginine; Biphenyl Compounds; Blood Pressure; Calcitonin Gene-Related Peptide; Captopril; Endothelins; Heart Rate; Hemodynamics; Hindlimb; Imidazoles; In Vitro Techniques; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitroarginine; Rats; Regional Blood Flow; Renal Circulation; Splanchnic Circulation; Tetrazoles; Vasoconstriction | 1991 |
Angiotensin II receptor subtypes are coupled with distinct signal-transduction mechanisms in neurons and astrocytes from rat brain.
Topics: Angiotensin II; Animals; Animals, Newborn; Astrocytes; Binding, Competitive; Biphenyl Compounds; Brain; Cells, Cultured; Imidazoles; Kinetics; Ligands; Losartan; Neurons; Oligopeptides; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Signal Transduction; Tetrazoles | 1991 |
Cardiac haemodynamic effects of the non-peptide, angiotensin II-receptor antagonist, DuP 753, in conscious Long Evans and Brattleboro rats.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Biphenyl Compounds; Blood Pressure; Cardiac Output; Central Venous Pressure; Coronary Circulation; Hemodynamics; Imidazoles; Losartan; Rats; Rats, Brattleboro; Species Specificity; Tetrazoles; Water Deprivation | 1991 |
Prolonged angiotensin II antagonism in spontaneously hypertensive rats. Hemodynamic and biochemical consequences.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Benzazepines; Biphenyl Compounds; Blood Pressure; Body Weight; Dose-Response Relationship, Drug; Hemodynamics; Imidazoles; Losartan; Male; Myocardium; Nephrectomy; Organ Size; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazoles; Time Factors | 1991 |
Nonpeptidic angiotensin II antagonists: synthesis and in vitro activity of a series of novel naphthalene and tetrahydronaphthalene derivatives.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Biphenyl Compounds; Cells, Cultured; Imidazoles; Losartan; Male; Models, Molecular; Molecular Conformation; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Rabbits; Rats; Receptors, Angiotensin; Structure-Activity Relationship; Tetrahydronaphthalenes; Tetrazoles | 1991 |
Effect of a nonpeptide angiotensin II receptor antagonist, DuP 753, on angiotensin-related water intake in rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cerebral Ventricles; Drinking Behavior; Imidazoles; Injections, Intraventricular; Injections, Subcutaneous; Losartan; Male; Mice; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Reference Values; Tetrazoles; Time Factors | 1991 |
Comparison of inhibitory potency by nonpeptide angiotensin II receptor antagonists PD123177 and DuP 753 on proximal nephron and renal transport.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biological Transport; Biphenyl Compounds; Electrolytes; Glomerular Filtration Rate; Imidazoles; Kidney; Kidney Tubules, Distal; Kidney Tubules, Proximal; Losartan; Male; Nephrons; Perfusion; Pyridines; Rats; Rats, Inbred Strains; Tetrazoles | 1991 |
Autoradiographic localization of subtypes of angiotensin II antagonist binding in the rat brain.
Topics: Angiotensin II; Animals; Autoradiography; Binding Sites; Biphenyl Compounds; Brain; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Inbred Strains; Saralasin; Tetrazoles; Tissue Distribution | 1991 |
Angiotensin-II receptor subtypes in median eminence and basal forebrain areas involved in regulation of pituitary function.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding, Competitive; Biphenyl Compounds; Cerebral Arteries; Dithiothreitol; Imidazoles; Losartan; Male; Median Eminence; Oligopeptides; Pituitary Gland; Prosencephalon; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles | 1991 |
Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype.
Topics: Adrenal Glands; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding Sites; Biphenyl Compounds; Imidazoles; Losartan; Pyridines; Rabbits; Rats; Receptors, Angiotensin; Stereoisomerism; Structure-Activity Relationship; Tetrazoles | 1991 |
Anxiolytic-like action of DuP753, a non-peptide angiotensin II receptor antagonist.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anti-Anxiety Agents; Avoidance Learning; Behavior, Animal; Biphenyl Compounds; Imidazoles; Light; Losartan; Male; Mice; Mice, Inbred Strains; Models, Psychological; Tetrazoles | 1990 |
Differential development of angiotensin II receptor subtypes in the rat brain.
Topics: Aging; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Brain; Imidazoles; Kinetics; Losartan; Male; Oligopeptides; Organ Specificity; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles | 1991 |
Quantitative autoradiography reveals different angiotensin II receptor subtypes in selected rat brain nuclei.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Dithiothreitol; Imidazoles; Losartan; Male; Medulla Oblongata; Oligopeptides; Paraventricular Hypothalamic Nucleus; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Subfornical Organ; Tetrazoles; Tissue Distribution | 1991 |
Differential regional haemodynamic effects of the non-peptide angiotensin II antagonist, DuP 753, in water-replete and water-deprived Brattleboro rats.
Topics: Angiotensin II; Animals; Captopril; Drinking; Hemodynamics; Imidazoles; Leg; Losartan; Male; Rats; Rats, Brattleboro; Regional Blood Flow; Tetrazoles; Vasodilation | 1991 |
Roles of renal and vascular renin in spontaneous hypertension and switching of the mechanism upon nephrectomy. Lack of hypotensive effects of inhibition of renin, converting enzyme, and angiotensin II receptor blocker after bilateral nephrectomy.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Enalapril; Hypertension; Hypotension; Imidazoles; Immunoglobulin G; Indans; Losartan; Nephrectomy; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Renin; Tetrazoles; Time Factors | 1991 |
DuP 753 can antagonize the effects of angiotensin II in rat liver.
Topics: Adenylyl Cyclase Inhibitors; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium; Imidazoles; Inositol Phosphates; Iodine Radioisotopes; Liver; Losartan; Male; Membranes; Pyridines; Rats; Rats, Inbred Strains; Second Messenger Systems; Tetrazoles | 1991 |
Characterization of angiotensin receptors mediating prostaglandin synthesis in C6 glioma cells.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Glioma; Imidazoles; Losartan; Oligopeptides; Peptide Fragments; Prostaglandins; Receptors, Angiotensin; Tetrazoles; Tumor Cells, Cultured | 1991 |
The nonpeptide angiotensin II antagonist DuP 753 is a potent stimulus for prostacyclin synthesis.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cells, Cultured; Dinoprostone; Epoprostenol; Humans; Imidazoles; Losartan; Muscle, Smooth, Vascular; Receptors, Angiotensin; Tetrazoles; Tumor Cells, Cultured | 1991 |
Effect of angiotensin II antagonism on canine renal sympathetic nerve function.
Topics: Angiotensin II; Animals; Blood Pressure; Captopril; Dogs; Electric Stimulation; Female; Imidazoles; Kidney; Losartan; Male; Norepinephrine; Pyridines; Saralasin; Sympathetic Nervous System; Tetrazoles; Vascular Resistance; Vasoconstriction | 1991 |
Identification and regulation of angiotensin II receptor subtypes on NG108-15 cells.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Binding, Competitive; Calcium; Hybrid Cells; Imidazoles; Losartan; Neurons; Oligopeptides; Receptors, Angiotensin; Signal Transduction; Tetrazoles; Tumor Cells, Cultured | 1991 |
Discrimination of angiotensin II receptor subtype distribution in the rat brain using non-peptidic receptor antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Brain; Brain Chemistry; Cell Nucleus; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles | 1991 |
Regional distribution of the two subtypes of angiotensin II receptor in rat brain using selective nonpeptide antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Brain; Cell Membrane; Imidazoles; Kinetics; Losartan; Male; Organ Specificity; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles | 1991 |
In vitro effects of DuP 753, a nonpeptide angiotensin II receptor antagonist, on human platelets and rat vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Platelets; Calcium; Dose-Response Relationship, Drug; Humans; Imidazoles; Losartan; Muscle, Smooth, Vascular; Rats; Tetrazoles | 1991 |
Nonpeptide angiotensin II receptor antagonists: insurmountable angiotensin II antagonism of EXP3892 is reversed by the surmountable antagonist DuP 753.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Drug Interactions; Imidazoles; Losartan; Male; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Pressoreceptors; Rabbits; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles; Vasoconstriction | 1991 |
Angiotensin II B-type receptor mediates phosphoinositide hydrolysis in mesangial cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cells, Cultured; Glomerular Mesangium; Hydrolysis; Imidazoles; Inositol 1,4,5-Trisphosphate; Losartan; Oligopeptides; Phosphatidylinositols; Rats; Receptors, Angiotensin; Stimulation, Chemical | 1990 |
Angiotensin II stimulates phosphoinositide turnover and phosphorylase through AII-1 receptors in isolated rat hepatocytes.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Cells, Cultured; Female; Imidazoles; Inositol Phosphates; Kinetics; Losartan; Phosphatidylinositols; Phosphorylase a; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles | 1990 |
Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP 753, an orally active antihypertensive agent.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Azoles; Blood Pressure; Bradykinin; Imidazoles; Losartan; Male; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Renin; Renin-Angiotensin System; Tetrazoles | 1990 |
Nonpeptide angiotensin II receptor antagonists. IX. Antihypertensive activity in rats of DuP 753, an orally active antihypertensive agent.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Azoles; Blood Pressure; Hypertension; Imidazoles; Ligation; Losartan; Male; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Renal Artery; Renin; Tetrazoles | 1990 |
Hypotensive action of DuP 753, an angiotensin II antagonist, in spontaneously hypertensive rats. Nonpeptide angiotensin II receptor antagonists: X.
Topics: Administration, Oral; Angiotensin II; Animals; Antihypertensive Agents; Azoles; Captopril; Furosemide; Imidazoles; Injections, Intravenous; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazoles | 1990 |
Discrimination of two angiotensin II receptor subtypes with a selective agonist analogue of angiotensin II, p-aminophenylalanine6 angiotensin II.
Topics: Adrenal Gland Neoplasms; Angiotensin II; Animals; Binding, Competitive; Cell Membrane; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Imidazoles; In Vitro Techniques; Liver; Losartan; Mercaptoethanol; Pheochromocytoma; Rats; Receptors, Angiotensin; Tetrazoles; Thionucleotides | 1990 |
Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent.
Topics: Administration, Oral; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Losartan; Male; Rabbits; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles | 1990 |
Proximal nephron and renal effects of DuP 753, a nonpeptide angiotensin II receptor antagonist.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Captopril; Diuretics; Imidazoles; Kidney Tubules, Proximal; Losartan; Male; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles | 1990 |
Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2).
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Dose-Response Relationship, Drug; Drinking; Epinephrine; Heart Rate; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles; Vasoconstriction | 1990 |
[3H]DUP 753, a highly potent and specific radioligand for the angiotensin II-1 receptor subtype.
Topics: Adrenal Cortex; Angiotensin II; Animals; Binding, Competitive; Imidazoles; Kinetics; Losartan; Microsomes; Rats; Receptors, Angiotensin; Tetrazoles; Tritium | 1990 |
Selective blockade of angiotensin responses in the rabbit isolated vas deferens by angiotensin receptor antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Imidazoles; Losartan; Male; Prostaglandins E; Rabbits; Receptors, Angiotensin; Saralasin; Tetrazoles; Vas Deferens | 1990 |
Non-peptide angiotensin II receptor antagonists discriminate subtypes of 125I-angiotensin II binding sites in the rat brain.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Hypothalamus; Imidazoles; Iodine Radioisotopes; Losartan; Male; Medulla Oblongata; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles | 1990 |
Angiotensin II receptor subtypes in the rat brain.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Animals; Autoradiography; Brain; Imidazoles; Iodine Radioisotopes; Losartan; Rats; Receptors, Angiotensin; Tetrazoles | 1990 |
Angiotensin II monoclonal antibody: blood pressure effects in normotensive and spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Antibodies, Monoclonal; Antihypertensive Agents; Blood Pressure; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Tetrazoles | 1990 |
Evidence for the presence of angiotensin II-type 1 receptors in brain.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Brain Chemistry; Imidazoles; Iodine Radioisotopes; Losartan; Male; Pyridines; Rats; Receptors, Angiotensin; Tetrazoles | 1990 |
Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP 753, an orally active antihypertensive agent.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Azoles; Binding Sites; Calcium; Imidazoles; In Vitro Techniques; Losartan; Male; Rabbits; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Structure-Activity Relationship; Tetrazoles; Vasoconstriction | 1990 |
Two distinct angiotensin II receptor binding sites in rat adrenal revealed by new selective nonpeptide ligands.
Topics: Adrenal Glands; Aldosterone; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Azoles; Binding, Competitive; Biphenyl Compounds; Cell Membrane; Dithiothreitol; Imidazoles; In Vitro Techniques; Ligands; Losartan; Pyridines; Rats; Receptors, Angiotensin; Saralasin | 1990 |
Nonpeptide angiotensin II receptor antagonists. Studies with EXP9270 and DuP 753.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta; Azoles; Biphenyl Compounds; Guinea Pigs; Hypertension, Renal; Ileum; Imidazoles; Losartan; Rabbits; Rats; Receptors, Angiotensin; Tetrazoles | 1990 |
Subclasses of angiotensin II binding sites and their functional significance.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding Sites; Blood Pressure; Female; Guanylyl Imidodiphosphate; Imidazoles; In Vitro Techniques; Inositol Phosphates; Losartan; Male; Muscle Contraction; Rabbits; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles | 1990 |
Preliminary biochemical characterization of two angiotensin II receptor subtypes.
Topics: Adrenal Glands; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Biphenyl Compounds; Dithiothreitol; Female; Humans; Imidazoles; Losartan; Muscle, Smooth; Oligopeptides; Rats; Receptors, Angiotensin; Uterus | 1989 |
4-(Heteroarylthio)-2-biphenylyltetrazoles as nonpeptide angiotensin II antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Abdominal; Binding, Competitive; Biphenyl Compounds; Imidazoles; Losartan; Male; Models, Molecular; Muscle Contraction; Naphthyridines; Quinolines; Rabbits; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Saralasin; Structure-Activity Relationship; Sulfides; Tetrazoles | 1995 |
Angiotensin II is a potent stimulator of MAP-kinase activity in neonatal rat cardiac fibroblasts.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Becaplermin; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Division; Cells, Cultured; DNA; Enzyme Activation; Fibroblasts; Heart Ventricles; Imidazoles; Immunoblotting; Losartan; Myocardium; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1995 |
Effects of the angiotensin II receptor antagonist losartan on 24-hour blood pressure profiles of primary and secondary hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Circadian Rhythm; Dose-Response Relationship, Drug; Enalapril; Hypertension; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Tetrazoles | 1995 |
Effects of losartan on angiotensin and bradykinin peptides and angiotensin-converting enzyme.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Bradykinin; Imidazoles; Losartan; Male; Organ Specificity; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Tetrazoles | 1995 |
Angiotensin II down-regulates the vascular smooth muscle AT1 receptor by transcriptional and post-transcriptional mechanisms: evidence for homologous and heterologous regulation.
Topics: Adenosine Triphosphate; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Base Sequence; Biphenyl Compounds; Calcium; Cyclic AMP; Cytoplasm; Dactinomycin; Down-Regulation; Enzyme Activation; Imidazoles; Losartan; Molecular Sequence Data; Muscle Proteins; Muscle, Smooth, Vascular; Protein Kinase C; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P2 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Receptors, Purinergic P1; Receptors, Purinergic P2; RNA, Messenger; Signal Transduction; Tetrazoles; Transcription, Genetic | 1995 |
Potentiation by enalaprilat of fenoldopam-evoked natriuresis is due to blockade of intrarenal production of angiotensin-II in rats.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Bradykinin; Diuresis; Dopamine Agonists; Drug Synergism; Enalaprilat; Fenoldopam; Glomerular Filtration Rate; Imidazoles; Kidney; Losartan; Male; Natriuresis; Rats; Rats, Sprague-Dawley; Tetrazoles | 1995 |
Is estrogen-induced pituitary hyperplasia and hyperprolactinaemia mediated by angiotensin II?
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Cell Division; Diethylstilbestrol; Enalapril; Enalaprilat; Estrogens; Estrogens, Non-Steroidal; Humans; Hyperpituitarism; Hyperplasia; Hyperprolactinemia; Imidazoles; Losartan; Prolactin; Pyridines; Rats; Rats, Inbred F344; Rats, Wistar; Tetrazoles; Tumor Cells, Cultured | 1995 |
Spinal angiotensin II influences reflex cardiovascular responses to muscle contraction.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cardiovascular Physiological Phenomena; Cats; Female; Imidazoles; Injections, Intravenous; Injections, Spinal; Losartan; Lumbosacral Region; Male; Muscle Contraction; Reflex; Spinal Cord; Tetrazoles; Thorax | 1995 |
Effects of losartan, an angiotensin II antagonist, on the development of cardiac hypertrophy due to volume overload.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Cardiac Volume; Cardiomegaly; Imidazoles; Losartan; Male; Organ Size; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Renin; Tetrazoles | 1995 |
The selective angiotensin AT1 receptor antagonist LR-B/081 potently inhibits drinking induced by central injection of angiotensin II in rats.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Carbachol; Dose-Response Relationship, Drug; Drinking; Eating; Imidazoles; Injections, Intraventricular; Lethal Dose 50; Losartan; Male; Milk; Pyrimidinones; Rats; Rats, Wistar; Renin-Angiotensin System; Tetrazoles; Thiophenes | 1995 |
Angiotensin AT1 receptor-mediated attenuation of cardiac hypertrophy due to volume overload: involvement of endothelin.
Topics: Amino Acid Sequence; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Azepines; Biphenyl Compounds; Cardiac Volume; Cardiomegaly; Endothelin Receptor Antagonists; Endothelins; Heart; Heart Ventricles; Hypertrophy, Left Ventricular; Imidazoles; Indoles; Losartan; Male; Molecular Sequence Data; Myocardium; Organ Size; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles; Time Factors | 1995 |
Effects of losartan on blood pressure, metabolic alterations, and vascular reactivity in the fructose-induced hypertensive rat.
Topics: Analysis of Variance; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Glucose; Blood Pressure; Endothelins; Fructose; Hypertension; Imidazoles; In Vitro Techniques; Insulin; Insulin Resistance; Losartan; Male; Mesenteric Artery, Superior; Rats; Rats, Sprague-Dawley; Tetrazoles; Triglycerides; Vasoconstriction | 1995 |
Regulation of luminal alkalinization and acidification in the cortical collecting duct by angiotensin II.
Topics: Acids; Alkalies; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Bicarbonates; Biphenyl Compounds; Female; Hydrogen-Ion Concentration; Imidazoles; In Vitro Techniques; Kidney Tubules, Collecting; Losartan; Osmolar Concentration; Perfusion; Rabbits; Tetrazoles | 1995 |
Angiotensin II-mediated facilitation of sympathetic neurotransmission in the spontaneously hypertensive rat is not associated with neuronal uptake of the peptide.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Electric Stimulation; Imidazoles; Injections, Intraperitoneal; Losartan; Male; Muscle, Smooth, Vascular; Oxidopamine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Species Specificity; Sympathetic Nervous System; Synaptic Transmission; Tetrazoles | 1993 |
Protein tyrosine phosphatase inhibition by angiotensin II in rat pheochromocytoma cells through type 2 receptor, AT2.
Topics: Adrenal Gland Neoplasms; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cell Membrane; Chromatography, Affinity; Guanosine Diphosphate; Imidazoles; Losartan; Oligopeptides; PC12 Cells; Pertussis Toxin; Pheochromocytoma; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphotyrosine; Protein Tyrosine Phosphatases; Pyridines; Rats; Receptors, Angiotensin; Tetrazoles; Thionucleotides; Tyrosine; Virulence Factors, Bordetella | 1994 |
Different effects of angiotensin-converting enzyme inhibition in human arteries and veins.
Topics: Acetylcholine; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Compounds; Bradykinin; Enalaprilat; Endothelium, Vascular; Humans; Imidazoles; In Vitro Techniques; Losartan; Mammary Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Saphenous Vein; Tetrazoles | 1993 |
Effects of angiotensin II on dopamine and serotonin turnover in the striatum of conscious rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Angiotensin II; Animals; Biphenyl Compounds; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Imidazoles; Kinetics; Losartan; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Serotonin; Tetrazoles; Time Factors | 1993 |
Angiotensin II (AII)-induced myocyte necrosis: role of the AII receptor.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Heart; Imidazoles; Losartan; Male; Myocardium; Necrosis; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1994 |
Angiotensin II inhibits calcium and M current channels in rat sympathetic neurons via G proteins.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Calcium; Calcium Channels; Egtazic Acid; Ethylmaleimide; Fluorescent Dyes; GTP-Binding Proteins; Guanosine Diphosphate; Imidazoles; In Vitro Techniques; Indoles; Ion Channels; Kinetics; Losartan; Membrane Potentials; Microscopy, Fluorescence; Neurons; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Signal Transduction; Somatostatin; Superior Cervical Ganglion; Tetrazoles; Thionucleotides; Virulence Factors, Bordetella | 1994 |
Endogenous vasoactive systems and the pressor effect of acute N omega-nitro-L-arginine methyl ester administration.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Arginine; Biphenyl Compounds; Blood Pressure; Desoxycorticosterone; Diet, Sodium-Restricted; Enalapril; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nicardipine; Nitric Oxide; Rats; Rats, Wistar; Renin-Angiotensin System; Tetrazoles; Vasoconstriction | 1994 |
Effect of various angiotensin receptor antagonists on cardiovascular responses to angiotensin II in pithed rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cardiac Output; Cardiovascular Physiological Phenomena; Cardiovascular System; Heart Rate; Imidazoles; Losartan; Male; Methylurea Compounds; Propranolol; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles | 1994 |
Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats.
Topics: Actins; Angiotensin II; Animals; Base Sequence; Biphenyl Compounds; Blood Pressure; Captopril; Cardiomegaly; DNA; DNA Primers; Dose-Response Relationship, Drug; Gene Expression; Genes, fos; Heart; Hydralazine; Hydroxyproline; Imidazoles; Isoproterenol; Labetalol; Losartan; Male; Methyldopa; Molecular Sequence Data; Myocardium; Myosins; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger; Tetrazoles; Transcription, Genetic | 1994 |
Angiotensin II stimulates sis-inducing factor-like DNA binding activity. Evidence that the AT1A receptor activates transcription factor-Stat91 and/or a related protein.
Topics: Angiotensin II; Animals; Animals, Newborn; Base Sequence; Cells, Cultured; DNA-Binding Proteins; Gene Expression Regulation; Imidazoles; In Vitro Techniques; Losartan; Molecular Sequence Data; Myocardium; Nuclear Proteins; Phosphotyrosine; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Signal Transduction; STAT1 Transcription Factor; Tetrazoles; Trans-Activators; Transcription Factors; Transcription, Genetic; Tyrosine | 1994 |
Tetrazole and carboxylate groups of angiotensin receptor antagonists bind to the same subsite by different mechanisms.
Topics: Amino Acid Sequence; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Carboxylic Acids; Hydrogen-Ion Concentration; Imidazoles; In Vitro Techniques; Ligands; Losartan; Molecular Sequence Data; Mutagenesis, Site-Directed; Rats; Receptors, Angiotensin; Sarcosine; Structure-Activity Relationship; Tetrazoles; Thermodynamics | 1995 |
Role of p70 S6 protein kinase in angiotensin II-induced protein synthesis in vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Abdominal; Biphenyl Compounds; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Imidazoles; Kinetics; Losartan; Male; Molecular Weight; Muscle, Smooth, Vascular; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Polyenes; Protein Biosynthesis; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred BN; Receptors, Angiotensin; Ribosomal Protein S6 Kinases; Sirolimus; Tetrazoles; Tyrosine | 1995 |
Loss of adenosine-induced negative inotropic effect in hyperexcited rabbit hearts: relationship to PKC.
Topics: Acetylcholine; Adenosine; Angiotensin II; Animals; Behavior, Animal; Biphenyl Compounds; Blood Pressure; Depression, Chemical; Enzyme Activation; Heart Rate; Imidazoles; In Vitro Techniques; Losartan; Male; Myocardial Contraction; Naphthalenes; Norepinephrine; Perfusion; Phentolamine; Phorbol 12,13-Dibutyrate; Polycyclic Compounds; Propranolol; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate; Tetrazoles | 1995 |
Angiotensin-(1-7) and nitric oxide interaction in renovascular hypertension.
Topics: Amino Acid Oxidoreductases; Angiotensin I; Angiotensin II; Angiotensins; Animals; Arginine; Biphenyl Compounds; Dogs; Hemodynamics; Hypertension, Renovascular; Imidazoles; Lisinopril; Losartan; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Peptidyl-Dipeptidase A; Tetrazoles | 1995 |
Effect of angiotensin II blockade on the fibroproliferative response to phenylephrine in the rat heart.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blotting, Northern; Fibrosis; Glyceraldehyde-3-Phosphate Dehydrogenases; Heart; Imidazoles; Indoles; Losartan; Male; Myocardium; Phenylephrine; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Renin-Angiotensin System; RNA; Tetrazoles | 1995 |
Functional interaction between losartan and central tachykinin NK3 receptors in the conscious rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Behavior, Animal; Biphenyl Compounds; Blood Pressure; Drinking; Heart Rate; Imidazoles; Losartan; Male; Neurokinin A; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P; Tachykinins; Tetrazoles; Time Factors | 1995 |
Expression of immunoreactive nitric oxide synthase isoforms in rat kidney. Effects of dietary salt and losartan.
Topics: Amino Acid Oxidoreductases; Angiotensin II; Animals; Biphenyl Compounds; Brain; Imidazoles; Immunohistochemistry; In Vitro Techniques; Juxtaglomerular Apparatus; Kidney; Losartan; Male; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Sodium, Dietary; Tetrazoles | 1995 |
The role of bradykinin and nitric oxide in the cardioprotective action of ACE inhibitors.
Topics: Adrenergic beta-Antagonists; Amino Acid Oxidoreductases; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Biphenyl Compounds; Bradykinin; Bradykinin Receptor Antagonists; Heart; Imidazoles; Losartan; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rabbits; Ramipril; Receptors, Angiotensin; Receptors, Bradykinin; Tetrazoles | 1995 |
Sensitive bioassay for the detection and quantification of angiotensin II in tissue culture medium.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biological Assay; Biphenyl Compounds; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Culture Media; Culture Media, Serum-Free; Glycogen Synthase Kinase 3; Imidazoles; Losartan; Rats; Receptors, Angiotensin; Sensitivity and Specificity; Tetrazoles; Transfection | 1995 |
Angiotensin II enhances responses to endothelin-1 in bovine bronchial smooth muscle.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Azepines; Biphenyl Compounds; Bronchi; Cattle; Drug Synergism; Endothelins; Imidazoles; In Vitro Techniques; Indoles; Losartan; Muscle Contraction; Muscle, Smooth; Receptors, Angiotensin; Receptors, Endothelin; Tetrazoles | 1994 |
Upregulation of cardiac angiotensin II AT1 receptors in congenital cardiomyopathic hamsters.
Topics: Analysis of Variance; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Cardiomyopathies; Cricetinae; Embryo, Mammalian; Heart Ventricles; Heterozygote; Imidazoles; In Vitro Techniques; Losartan; Male; Mesocricetus; Myocardium; Necrosis; Radioligand Assay; Receptors, Angiotensin; Tetrazoles; Up-Regulation | 1995 |
Effects of U-97018 on pressor responses to intracerebroventricularly administered angiotensin II in conscious normotensive rats.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Imidazoles; Injections, Intravenous; Injections, Intraventricular; Losartan; Male; Pyridazines; Pyridines; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Saralasin; Tetrazoles | 1995 |
Tissue- and subtype-specific modulation of angiotensin II receptors by chronic treatment with cyclosporin A, angiotensin-converting enzyme inhibitors and AT1 antagonists.
Topics: Administration, Oral; Adrenal Cortex; Adrenal Medulla; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Cyclosporine; Down-Regulation; Drug Interactions; Imidazoles; Kidney; Lisinopril; Liver; Losartan; Male; Pyridines; Quinolines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles; Up-Regulation | 1995 |
[Bronchospasm and cough connected to Losartan].
Topics: Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Bronchial Spasm; Cough; Humans; Imidazoles; Losartan; Male; Middle Aged; Tetrazoles | 1995 |
Chronic Losartan treatment blocks isoproterenol-induced dipsogenesis.
Topics: Adrenergic beta-Agonists; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Body Weight; Drinking Behavior; Imidazoles; Isoproterenol; Losartan; Male; Rats; Rats, Sprague-Dawley; Tetrazoles | 1995 |
Tubulointerstitial injury and impaired renal function after recovery from acute puromycin nephrosis.
Topics: Acute Disease; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Glomerular Filtration Rate; Imidazoles; Kidney; Kidney Tubules; Losartan; Male; Natriuresis; Nephrosis; Puromycin; Rats; Tetrazoles; Time Factors | 1995 |
Angiotensin II induces the expression of c-fos mRNA in the central nervous system of the rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Brain; Brain Stem; DNA, Complementary; Gene Expression; Genes, fos; Imidazoles; Injections, Intraventricular; Losartan; Male; Mesencephalon; Polymerase Chain Reaction; Rats; Rats, Wistar; RNA, Messenger; Tetrazoles | 1995 |
In vivo pharmacology of L-159,913, a new highly potent and selective nonpeptide angiotensin II receptor antagonist.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Dogs; Female; Hypertension; Imidazoles; Kidney; Losartan; Macaca mulatta; Male; Natriuresis; Pan troglodytes; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin; Tetrazoles; Triazoles | 1995 |
Interactions between angiotensin II and norepinephrine on renin release by juxtaglomerular cells.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Fluorescent Antibody Technique; Fura-2; Image Processing, Computer-Assisted; Imidazoles; Juxtaglomerular Apparatus; Losartan; Norepinephrine; Prazosin; Rats; Rats, Sprague-Dawley; Renin; Tetrazoles; Vasoconstrictor Agents | 1995 |
Effects of irbesartan (SR47436/BMS-186295) on angiotensin II-induced pressor responses in the pithed rat: potential mechanisms of action.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Imidazoles; Irbesartan; Losartan; Male; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles; Time Factors | 1995 |
Identification of atypical (non-AT1, non-AT2) angiotensin binding sites with high affinity for angiotensin I on IEC-18 rat intestinal epithelial cells.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Binding Sites; Binding, Competitive; Biphenyl Compounds; Cell Line; Epithelium; Imidazoles; Intestinal Mucosa; Intestine, Small; Losartan; Oligopeptides; Peptide Fragments; Pyridines; Rats; Receptors, Angiotensin; Tetrazoles | 1995 |
Effect of losartan on haematology and haemorheology in elderly patients with essential hypertension: a pilot study.
Topics: Aged; Angiotensin II; Biphenyl Compounds; Blood Circulation; Blood Viscosity; Female; Hematocrit; Humans; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Pilot Projects; Tetrazoles | 1995 |
Inhibition by ketamine of muscarinic acetylcholine receptor function.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Calcium; Calcium Channels; Chloride Channels; Female; Imidazoles; Ketamine; Losartan; Membrane Potentials; Methacholine Chloride; Muscarine; Muscarinic Antagonists; Oocytes; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Recombination, Genetic; Signal Transduction; Tetrazoles; Xenopus | 1995 |
The conformation and activity relationship of fused analogs of DuP753.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Imidazoles; Losartan; Microsomes, Liver; Models, Molecular; Molecular Conformation; Molecular Structure; Rats; Rats, Wistar; Structure-Activity Relationship; Tetrazoles | 1995 |
Left ventricular fibrosis in renovascular hypertensive rats. Effect of losartan and spironolactone.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biochemical Phenomena; Biochemistry; Biphenyl Compounds; Cardiomyopathies; Collagen; Endomyocardial Fibrosis; Fibrosis; Hypertension, Renovascular; Hypertrophy, Left Ventricular; Imidazoles; Losartan; Microscopy, Polarization; Polymerase Chain Reaction; Rats; Rats, Wistar; RNA, Messenger; Spironolactone; Tetrazoles | 1995 |
Heterogeneity in vascular smooth muscle responsiveness to angiotensin II. Role of endothelin.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Arteries; Biphenyl Compounds; Endothelin Receptor Antagonists; Endothelins; Imidazoles; In Vitro Techniques; Losartan; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Tail; Tetrazoles | 1995 |
Studies of the renal effects of angiotensin II receptor blockade: the confounding factor of acute water loading on the action of vasoactive systems.
Topics: Adult; Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Humans; Imidazoles; Irbesartan; Kidney; Kidney Tubules; Losartan; Natriuresis; Potassium; Renin-Angiotensin System; Sodium; Sodium, Dietary; Tetrazoles; Uric Acid; Vasomotor System; Water | 1995 |
Regulation of renal growth factors and clusterin by AT1 receptors during neonatal ureteral obstruction.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Biphenyl Compounds; Blotting, Northern; Clusterin; DNA; Epidermal Growth Factor; Gene Expression; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycoproteins; Imidazoles; Kidney; Losartan; Molecular Chaperones; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Reference Values; Renin; RNA, Messenger; Tetrazoles; Transforming Growth Factor beta; Ureteral Obstruction | 1995 |
Angiotensin II-induced thirst, but not sodium appetite, via AT1 receptors in organum cavum prelamina terminalis.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Appetite; Biphenyl Compounds; Dose-Response Relationship, Drug; Imidazoles; Losartan; Male; Microinjections; Oligopeptides; Prosencephalon; Rats; Rats, Wistar; Receptors, Angiotensin; Sodium, Dietary; Tetrazoles; Thirst | 1995 |
Central ANG II-receptor antagonists impair cardiovascular and vasopressin response to hemorrhage in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine Vasopressin; Biphenyl Compounds; Blood Pressure; Cerebral Ventricles; Heart Rate; Hemodynamics; Hemorrhage; Homeostasis; Imidazoles; Injections, Intraventricular; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Reference Values; Renin; Saralasin; Species Specificity; Tetrazoles; Time Factors | 1995 |
Control of carotid vasomotor tone by local renin-angiotensin system in normotensive and spontaneously hypertensive rats. Role of endothelium and flow.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Carotid Arteries; Endothelium, Vascular; Hypertension; Imidazoles; In Vitro Techniques; Lisinopril; Losartan; Perfusion; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin-Angiotensin System; Tetrazoles; Transducers; Vasomotor System | 1995 |
Effect of losartan, an AT1 selective angiotensin II receptor antagonist, on isoproterenol-induced cardiac ornithine decarboxylase activity.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Heart; Imidazoles; In Vitro Techniques; Isoproterenol; Losartan; Metoprolol; Myocardium; Nephrectomy; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Wistar; Tetrazoles | 1995 |
Angiotensin-converting enzyme inhibition in infarct-induced heart failure in rats: bradykinin versus angiotensin II.
Topics: Adrenergic beta-Antagonists; Analysis of Variance; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Bradykinin; Disease Models, Animal; Heart; Heart Failure; Hemodynamics; Imidazoles; Isoquinolines; Losartan; Male; Myocardial Contraction; Myocardial Infarction; Myocardium; Organ Size; Rats; Rats, Wistar; Tetrahydroisoquinolines; Tetrazoles | 1994 |
In vitro pharmacological characterization of UP 269-6, a novel nonpeptide angiotensin II receptor antagonist.
Topics: Adrenal Medulla; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Binding, Competitive; Biphenyl Compounds; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle, Smooth, Vascular; Pyrimidines; Radioligand Assay; Rats; Tetrazoles | 1995 |
Sympathetic nerve activity in conscious renal hypertensive rats treated with an angiotensin converting enzyme inhibitor or an angiotensin II antagonist.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Heart Rate; Hypertension, Renal; Imidazoles; Lisinopril; Losartan; Male; Nitroprusside; Rats; Rats, Wistar; Renin-Angiotensin System; Splanchnic Nerves; Sympathetic Nervous System; Tetrazoles | 1995 |
Influence of nonpeptide angiotensin II receptor antagonist, losartan, on neurogenic vasoconstriction.
Topics: Adenosine Triphosphate; Analysis of Variance; Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Decerebrate State; Electric Stimulation; Imidazoles; In Vitro Techniques; Losartan; Male; Prazosin; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Synaptic Transmission; Tetrazoles; Vasoconstriction; Yohimbine | 1995 |
Hemodynamic effects of angiotensin II and the influence of angiotensin receptor antagonists in pithed rabbits.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Decerebrate State; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Losartan; Male; Methylurea Compounds; Propranolol; Pyridines; Rabbits; Tetrazoles; Ventricular Function, Left | 1995 |
Comparison of systemic and direct intrarenal angiotensin II blockade on sodium excretion in rats.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Diet, Sodium-Restricted; Imidazoles; Kidney; Losartan; Male; Natriuresis; Pharmaceutical Vehicles; Rats; Rats, Sprague-Dawley; Sodium Chloride; Tetrazoles | 1995 |
Antihypertensive therapy targeted to the needs of the patient: focus on the renin-angiotensin system; older and newer agents.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Humans; Hypertension; Imidazoles; Losartan; Quality of Life; Renin-Angiotensin System; Tetrazoles | 1995 |
Angiotensin receptors: physiology and pharmacology.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Receptors, Angiotensin; Renin-Angiotensin System; Tetrazoles | 1995 |
Loss of angiotensin-II receptors in portal hypertensive rabbits.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Biphenyl Compounds; Hypertension, Portal; Imidazoles; Ligation; Losartan; Male; Mesenteric Arteries; Portal Vein; Pyridines; Rabbits; Receptors, Angiotensin; Tetrazoles | 1995 |
Localization of the angiotensin II and its receptor subtype expression in human endometrium and identification of a novel high-affinity angiotensin II binding site.
Topics: Adult; Angiotensin II; Arterioles; Biphenyl Compounds; Endometrium; Endothelium; Endothelium, Vascular; Female; Gene Expression Regulation; Humans; Imidazoles; In Situ Hybridization; Losartan; Menstrual Cycle; Pyridines; Receptors, Angiotensin; RNA, Messenger; Tetrazoles | 1995 |
Cardiovascular effects after the intracerebroventricular administration of peptide and nonpeptide angiotensin antagonists in Dahl salt-sensitive rats.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Brain; Heart Rate; Hypertension; Imidazoles; Injections, Intraventricular; Losartan; Male; Rats; Renin-Angiotensin System; Tetrazoles | 1995 |
Effects of chronic treatment with angiotensin converting enzyme inhibitor or an angiotensin receptor antagonist in two-kidney, one-clip hypertensive rats.
Topics: Albuminuria; Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Body Weight; Enalapril; Hemodynamics; Hypertension, Renovascular; Imidazoles; Kidney; Losartan; Male; Organ Size; Random Allocation; Rats; Rats, Wistar; Tetrazoles | 1995 |
Tonic stimulation of renin gene expression by nitric oxide is counteracted by tonic inhibition through angiotensin II.
Topics: Analysis of Variance; Angiotensin II; Animals; Arginine; Biphenyl Compounds; Enzyme Precursors; Enzyme Repression; Gene Expression Regulation, Enzymologic; Imidazoles; Indomethacin; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Ramipril; Rats; Rats, Sprague-Dawley; Renin; RNA, Messenger; Tetrazoles | 1995 |
Stable expression of a functional rat angiotensin II (AT1A) receptor in CHO-K1 cells: rapid desensitization by angiotensin II.
Topics: Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Base Sequence; Calcium; Cell Membrane; CHO Cells; Concanavalin A; Cricetinae; Gene Expression; Guanosine Triphosphate; Imidazoles; Losartan; Membrane Potentials; Molecular Sequence Data; Pyridines; Rats; Receptors, Angiotensin; Tetradecanoylphorbol Acetate; Tetrazoles; Transfection; Verapamil | 1995 |
Identification and characterization of functional angiotensin II receptors in human neuroblastoma cells.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Binding, Competitive; Biphenyl Compounds; Calcium; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Imidazoles; Kinetics; Losartan; Neuroblastoma; Oligopeptides; Pyridines; Receptors, Angiotensin; Tetrazoles; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1995 |
NaCl injections in brain induce natriuresis and blood pressure responses sensitive to ANG II AT1 receptors.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Brain; Imidazoles; Injections; Losartan; Male; Natriuresis; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Saline Solution, Hypertonic; Sodium Chloride; Tetrazoles | 1995 |
Human plasma protein binding of the angiotensin II receptor antagonist losartan potassium (DuP 753/MK 954) and its pharmacologically active metabolite EXP3174.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Blood Proteins; Humans; Imidazoles; Losartan; Protein Binding; Receptors, Angiotensin; Tetrazoles | 1995 |
Disulfide bridges in extracellular domains of angiotensin II receptor type IA.
Topics: Angiotensin II; Animals; Binding, Competitive; Biphenyl Compounds; Cell Line; Cloning, Molecular; Disulfides; Dithiothreitol; Flow Cytometry; Imidazoles; Kidney; Losartan; Mutagenesis, Site-Directed; Protein Binding; Rats; Receptors, Angiotensin; Tetrazoles | 1995 |
Acute myocardial and vascular responses to specific angiotensin II antagonism in the spontaneously hypertensive rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Electrocardiography; Heart; Hemodynamics; Hypertension; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazoles; Vasoconstriction | 1995 |
Losartan in patients with renal insufficiency.
Topics: Acute Kidney Injury; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Diabetic Nephropathies; Humans; Hypertension; Hypertension, Renal; Imidazoles; Kidney Failure, Chronic; Losartan; Tetrazoles | 1995 |
The angiotensin II receptor antagonist losartan: a new advance in the treatment of hypertension.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Calcium Channel Blockers; Dose-Response Relationship, Drug; Drug Costs; Humans; Hypertension; Imidazoles; Losartan; Tetrazoles | 1995 |
Losartan-sensitive AII receptors linked to depolarization-dependent cortisol secretion through a novel signaling pathway.
Topics: Adrenal Glands; Angiotensin II; Animals; Biphenyl Compounds; Cattle; Enzyme Activation; GTP-Binding Proteins; Guanine Nucleotides; Hydrocortisone; Imidazoles; In Vitro Techniques; Ion Channel Gating; Losartan; Membrane Potentials; Phospholipases; Phosphorylation; Potassium Channel Blockers; Protein Kinases; Receptors, Angiotensin; Signal Transduction; Tetrazoles | 1995 |
[Medical angiotensin II-receptor blockade in hypertension and heart failure].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Cardiovascular Agents; Heart Failure; Humans; Hypertension; Imidazoles; Losartan; Renin; Tetrazoles | 1995 |
Central administration of PD 123319 or EXP-3174 inhibits effects of angiotensin II.
Topics: Angiotensin II; Animals; Brain; Hemodynamics; Imidazoles; Injections, Intraventricular; Losartan; Male; Pyridines; Rats; Rats, Inbred Strains; Substance P; Tetrazoles | 1993 |
Effects of angiotensin II receptor blockade on remnant glomerular permselectivity.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Dextran Sulfate; Dextrans; Glomerular Filtration Rate; Imidazoles; Kidney Glomerulus; Losartan; Male; Nephrectomy; Permeability; Proteinuria; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles | 1993 |
Differential responses to angiotensin-(1-7) in the feline mesenteric and hindquarters vascular beds.
Topics: Amino Acid Oxidoreductases; Angiotensin I; Angiotensin II; Angiotensin III; Animals; Arginine; Biphenyl Compounds; Cats; Hindlimb; Imidazoles; Losartan; Meclofenamic Acid; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptide Fragments; Perfusion; Tetrazoles; Vascular Resistance; Vasoconstriction | 1993 |
Role of kinins and nitric oxide in the effects of angiotensin converting enzyme inhibitors on neointima formation.
Topics: Amino Acid Oxidoreductases; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Biphenyl Compounds; Bradykinin; Carotid Arteries; Imidazoles; Kinins; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptors, Bradykinin; Receptors, Neurotransmitter; Tetrazoles; Tunica Intima | 1993 |
Regulation of endothelin-1 mRNA by angiotensin II in rat heart endothelial cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blotting, Northern; Cells, Cultured; Endothelin-1; Endothelins; Endothelium, Vascular; Gene Expression Regulation; Imidazoles; Losartan; Myocardium; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Protein Precursors; Protein Synthesis Inhibitors; Rats; RNA, Messenger; Tetrazoles | 1993 |
Systemic and coronary effects of the angiotensin II receptor antagonist EXP3174 in dogs.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Coronary Circulation; Dogs; Enalaprilat; Female; Furosemide; Hemodynamics; Imidazoles; Losartan; Male; Renin-Angiotensin System; Tetrazoles | 1993 |
Effects of blocking the angiotensin II receptor, converting enzyme, and renin activity on the renal hemodynamics of normotensive guinea pigs.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Body Weight; Diuresis; Glomerular Filtration Rate; Guinea Pigs; Imidazoles; Kidney Function Tests; Lisinopril; Losartan; Male; Renal Circulation; Renin; Tetrazoles | 1993 |
Glucocorticoids but not mineralocorticoids modulate endothelin-1 and angiotensin II binding in SHR vascular smooth muscle cells.
Topics: Aldosterone; Androstanols; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cells, Cultured; Endothelin Receptor Antagonists; Endothelins; Glucocorticoids; Hypertension; Imidazoles; Losartan; Male; Mifepristone; Muscle, Smooth, Vascular; Peptides, Cyclic; Rats; Rats, Inbred SHR; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Tetrazoles; Viper Venoms | 1995 |
Neuromodulatory effects of angiotensin II in the visual layers of the rat superior colliculus.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Evoked Potentials, Visual; Imidazoles; Losartan; Neurotransmitter Agents; Rats; Receptors, Angiotensin; Superior Colliculi; Tetrazoles; Visual Pathways | 1994 |
Effects of central losartan on plasma renin and centrally mediated natriuresis.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Female; Imidazoles; Infusions, Parenteral; Injections, Intraventricular; Losartan; Natriuresis; Renin; Saline Solution, Hypertonic; Sheep; Sodium; Tetrazoles | 1994 |
Distribution of Fos in rat brain resulting from endogenously-generated angiotensin II.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Brain; Imidazoles; Immunohistochemistry; Isoproterenol; Losartan; Male; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Tetrazoles; Tissue Distribution | 1994 |
Angiotensin(1-7) is an antagonist at the type 1 angiotensin II receptor.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Imidazoles; In Vitro Techniques; Losartan; Male; Peptide Fragments; Rabbits; Rats; Rats, Sprague-Dawley; Tetrazoles | 1994 |
Type 1 angiotensin II receptors in rat and human sperm.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Epididymis; Fluorescent Antibody Technique; Humans; Imidazoles; Losartan; Male; Rats; Receptors, Angiotensin; Seminiferous Tubules; Sperm Motility; Sperm Tail; Tetrazoles | 1995 |
Role of angiotensin II in hemodynamic responses to dynamic exercise in miniswine.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Cardiac Output; Catecholamines; Female; Hemodynamics; Imidazoles; Losartan; Male; Physical Exertion; Receptors, Angiotensin; Regional Blood Flow; Renal Circulation; Splanchnic Circulation; Swine; Swine, Miniature; Tetrazoles; Vascular Resistance; Vasoconstriction | 1995 |
Effects of angiotensin II on isolated rabbit afferent arterioles.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Arterioles; Aspirin; Biphenyl Compounds; Imidazoles; In Vitro Techniques; Indomethacin; Losartan; Lysine; Male; Nitric Oxide; omega-N-Methylarginine; Prostaglandin Antagonists; Prostaglandins; Rabbits; Renal Circulation; Tetrazoles; Vascular Resistance | 1994 |
Cardiac refractoriness in rats is reduced by angiotensin II.
Topics: Action Potentials; Angiotensin II; Animals; Biphenyl Compounds; Drug Interactions; Electrophysiology; Heart Ventricles; Imidazoles; In Vitro Techniques; Losartan; Male; Membrane Potentials; Muscle, Smooth, Vascular; Phentolamine; Propranolol; Rats; Tetrazoles | 1995 |
Effect of angiotensin II receptor blocker on angiotensin II stimulated DNA synthesis of cultured human aortic smooth muscle cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Aorta; Arteriosclerosis; Biphenyl Compounds; Cell Division; Cells, Cultured; Disease Progression; DNA; Humans; Imidazoles; Kinetics; Losartan; Muscle, Smooth, Vascular; Receptors, Angiotensin; Renin-Angiotensin System; Stimulation, Chemical; Tetrazoles; Thymidine; Tritium | 1995 |
In vivo pharmacology of a novel AT1 selective angiotensin II receptor antagonist, MK-996.
Topics: Administration, Oral; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Bradykinin; Dogs; Enalapril; Female; Imidazoles; Injections, Intravenous; Losartan; Macaca mulatta; Male; Nitroglycerin; Pan troglodytes; Pyridines; Rats; Rats, Sprague-Dawley; Tetrazoles | 1995 |
Acute and chronic losartan administration: effect on angiotensin II content and modulation of [3H]norepinephrine release from rat interscapular brown adipose tissue.
Topics: Adipose Tissue, Brown; Angiotensin II; Animals; Biphenyl Compounds; Imidazoles; In Vitro Techniques; Losartan; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Tetrazoles; Time Factors; Tritium | 1994 |
Oxidation of the angiotensin II receptor antagonist losartan (DuP 753) in human liver microsomes. Role of cytochrome P4503A(4) in formation of the active metabolite EXP3174.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzoflavones; Biotransformation; Biphenyl Compounds; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Imidazoles; Losartan; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Receptors, Angiotensin; Tetrazoles | 1995 |
Cerebroventricular injection of angiotensin II antagonist: effects on blood pressure responses to central and systemic angiotensin II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Imidazoles; Injections, Intraventricular; Losartan; Male; Microinjections; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1995 |
Absorption and glucuronidation of the angiotensin II receptor antagonist losartan by the rat intestine.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Duodenum; Glucuronates; Imidazoles; Intestinal Absorption; Jejunum; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1995 |
Interaction between nitric oxide and angiotensin II on antidiuresis and norepinephrine overflow induced by stimulation of renal nerves in anesthetized dogs.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine; Biphenyl Compounds; Diuresis; Dogs; Drug Interactions; Electric Stimulation; Female; Glomerular Filtration Rate; Imidazoles; Infusions, Intra-Arterial; Kidney; Kidney Function Tests; Losartan; Male; Nitric Oxide; Nitroarginine; Norepinephrine; Renal Circulation; Sodium; Synaptic Transmission; Tetrazoles | 1995 |
An angiotensin-independent, hypotension-induced, sodium appetite in the rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Appetite; Biphenyl Compounds; Bis-Trimethylammonium Compounds; Blood Pressure; Drinking; Ganglionic Blockers; Hypotension; Imidazoles; Losartan; Male; Rats; Rats, Wistar; Sodium; Tetrazoles | 1995 |
[Losartan prevents pulmonary hypertension induced by a thromboxane A2 analog].
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Hypertension, Pulmonary; Imidazoles; Losartan; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Sprague-Dawley; Tetrazoles; Thromboxane A2; Vasoconstrictor Agents | 1994 |
Convergence of angiotensin II and platelet-derived growth factor receptor signaling cascades in vascular smooth muscle cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Culture Media, Conditioned; GRB2 Adaptor Protein; GTP-Binding Proteins; Humans; Imidazoles; Losartan; Muscle, Smooth, Vascular; Phosphorylation; Precipitin Tests; Protein Binding; Proteins; Rats; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tetrazoles | 1995 |
The docking of Arg2 of angiotensin II with Asp281 of AT1 receptor is essential for full agonism.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Arginine; Aspartic Acid; Binding Sites; Biphenyl Compounds; Imidazoles; Inositol Phosphates; Losartan; Models, Molecular; Protein Binding; Receptors, Angiotensin; Structure-Activity Relationship; Tetrazoles | 1995 |
Angiotensinogen depletion by high renin levels in hypertensive rats: no evidence for tonic stimulation of angiotensinogen by angiotensin II.
Topics: Administration, Oral; Angiotensin II; Angiotensinogen; Animals; Biphenyl Compounds; Diet; Hypertension; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Renin; Sodium Chloride, Dietary; Tetrazoles | 1995 |
Antihypertensive and renal-protective effects of losartan in streptozotocin diabetic rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Captopril; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Glomerulosclerosis, Focal Segmental; Hypertension; Imidazoles; Kidney; Losartan; Male; Organ Size; Random Allocation; Rats; Rats, Inbred SHR; Tetrazoles | 1995 |
Localization of angiotensin II receptor subtypes in the rabbit heart.
Topics: Acetylcholinesterase; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Biphenyl Compounds; Cell Membrane; Heart Atria; Heart Conduction System; Imidazoles; Immunohistochemistry; Iodine Radioisotopes; Losartan; Male; Myocardium; Oligopeptides; Rabbits; Receptors, Angiotensin; Tetrazoles | 1995 |
Pharmacological profile of ME3221, a novel angiotensin II receptor antagonist.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Biphenyl Compounds; Blood Pressure; Bradykinin; Callithrix; Disease Models, Animal; Drug Evaluation; Female; Femoral Artery; Heart Rate; Hypertension, Renal; Imidazoles; Losartan; Male; Rabbits; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Species Specificity; Tetrazoles | 1995 |
Angiotensin AT1 receptor-mediated vasopressin release and drinking are potentiated by an AT2 receptor antagonist.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Drinking; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles; Vasopressins | 1995 |
Modulation of tubuloglomerular feedback by angiotensin II type 1 receptors during the development of Goldblatt hypertension.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Feedback; Hypertension, Renovascular; Imidazoles; Kidney Glomerulus; Kidney Tubules; Losartan; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1995 |
Comparison of the effects of angiotensin II, losartan, and enalapril on baroreflex control of heart rate in conscious rabbits.
Topics: Angiotensin II; Animals; Baroreflex; Biphenyl Compounds; Blood Pressure; Enalapril; Female; Heart Rate; Imidazoles; In Vitro Techniques; Losartan; Male; Rabbits; Tetrazoles | 1995 |
Evidence for the involvement of different receptor subtypes in the pre- and postjunctional actions of angiotensin II at rat sympathetic neuroeffector sites.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Electric Stimulation; Female; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle, Smooth, Vascular; Neuroeffector Junction; Norepinephrine; Pyridines; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Tetrazoles; Vas Deferens | 1995 |
Losartan for hypertension.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Humans; Hypertension; Imidazoles; Intestinal Absorption; Losartan; Tetrazoles | 1995 |
Regulation of aldosterone biosynthesis by adrenal renin is mediated through AT1 receptors in renin transgenic rats.
Topics: Adrenal Cortex; Aldosterone; Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Genetically Modified; Antihypertensive Agents; Biphenyl Compounds; Blotting, Northern; Diet, Sodium-Restricted; Gene Expression Regulation, Enzymologic; Imidazoles; Kidney Cortex; Losartan; Male; Mice; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin; Renin-Angiotensin System; RNA, Messenger; Tetrazoles | 1995 |
Angiotensin II receptor subtypes in the human central nervous system.
Topics: Aged; Aged, 80 and over; Angiotensin II; Angiotensin Receptor Antagonists; Autoradiography; Biphenyl Compounds; Brain; Central Nervous System; Female; Humans; Imidazoles; Losartan; Male; Pyridines; Radioligand Assay; Receptors, Angiotensin; Spinal Cord; Tetrazoles | 1995 |
Prevention of angiotensin II induced myocyte necrosis and coronary vascular damage by lisinopril and losartan in the rat.
Topics: Angiotensin I; Angiotensin II; Animals; Biphenyl Compounds; Coronary Vessels; Dose-Response Relationship, Drug; Heart; Hypertension, Renovascular; Imidazoles; Lisinopril; Losartan; Male; Necrosis; Rats; Rats, Sprague-Dawley; Tetrazoles | 1995 |
The role of angiotensin II in the regulation of blood flow to choroid plexuses and cerebrospinal fluid formation in the rat.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Flow Velocity; Blood Pressure; Cerebral Cortex; Cerebrospinal Fluid; Choroid Plexus; Imidazoles; Infusions, Intravenous; Losartan; Male; Rats; Rats, Sprague-Dawley; Tetrazoles | 1995 |
Angiotensin II regulates H(+)-ATPase activity in rat cortical collecting duct.
Topics: Adenosine Diphosphate; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anti-Bacterial Agents; Biphenyl Compounds; Collagenases; Ethylmaleimide; Female; H(+)-K(+)-Exchanging ATPase; Imidazoles; Kidney Cortex; Kidney Tubules, Collecting; Losartan; Macrolides; Proton-Translocating ATPases; Pyridines; Rats; Rats, Sprague-Dawley; Tetrazoles | 1994 |
BMS-180560, an insurmountable inhibitor of angiotensin II-stimulated responses: comparison with losartan and EXP3174.
Topics: Adrenal Cortex; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Extracellular Space; Imidazoles; In Vitro Techniques; Losartan; Male; Membranes; Muscle Contraction; Muscle, Smooth, Vascular; Phosphatidylinositols; Rabbits; Rats; Tetrazoles | 1994 |
Evidence for an antagonistic angiotensin II/alpha 2-adrenoceptor interaction in the nucleus tractus solitarii.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding, Competitive; Biphenyl Compounds; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Epinephrine; Heart Rate; Imidazoles; Losartan; Male; Microinjections; Norepinephrine; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Angiotensin; Software; Solitary Nucleus; Specific Pathogen-Free Organisms; Tetrazoles | 1994 |
Angiotensinogen dependency of blood pressure in two high-renin hypertensive rat models.
Topics: Angiotensin II; Angiotensinogen; Animals; Biphenyl Compounds; Blood Pressure; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Renin; Sodium, Dietary; Tetrazoles | 1994 |
Cardiovascular hypertrophy in one-kidney, one clip renal hypertensive rats: a role for angiotensin II?
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Biphenyl Compounds; Blood Pressure; Body Weight; Cardiomegaly; Hypertension, Renovascular; Hypertrophy; Imidazoles; Indoles; Losartan; Male; Muscle, Smooth, Vascular; Perindopril; Rats; Rats, Inbred WKY; Tetrazoles | 1994 |
Neuronal excitation by angiotensin II in the rostral ventrolateral medulla of the rat in vitro.
Topics: Adrenergic alpha-Agonists; Angiotensin II; Animals; Biphenyl Compounds; Brimonidine Tartrate; Evoked Potentials; Imidazoles; In Vitro Techniques; Kynurenic Acid; Losartan; Medulla Oblongata; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Tetrazoles; Time Factors | 1995 |
Angiotensin II receptor binding following myocardial infarction in the rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Biphenyl Compounds; Collagen; Fibrosis; Foreign-Body Reaction; Imidazoles; Lisinopril; Losartan; Male; Myocardial Infarction; Myocardium; Peptidyl-Dipeptidase A; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1994 |
Angiotensin 1-7 has a biphasic effect on fluid absorption in the proximal straight tubule.
Topics: Adsorption; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Bicarbonates; Biphenyl Compounds; Imidazoles; In Vitro Techniques; Ion Transport; Kidney Tubules, Proximal; Kinetics; Losartan; Male; Peptide Fragments; Perfusion; Permeability; Pyridines; Rats; Rats, Sprague-Dawley; Tetrazoles | 1994 |
The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Base Sequence; Binding, Competitive; Biphenyl Compounds; Cell Division; Cells, Cultured; Coronary Vessels; DNA; DNA Primers; Dose-Response Relationship, Drug; Endothelium, Vascular; Gene Expression; Imidazoles; Kinetics; Losartan; Molecular Sequence Data; Muscle, Smooth, Vascular; Oligopeptides; Polymerase Chain Reaction; Pyridines; Rats; Receptors, Angiotensin; RNA, Messenger; Tetrazoles; Thymidine | 1995 |
The effect of acute angiotensin II blockade on renal function in rats with reduced renal mass.
Topics: Albuminuria; Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Hypertension, Renal; Imidazoles; Kidney; Losartan; Male; Natriuresis; Nephrectomy; Punctures; Rats; Rats, Wistar; Tetrazoles; Time Factors | 1994 |
Analysis of responses to ANG IV: effects of PD-123319 and DuP-753 in the pulmonary circulation of the rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Bradykinin; Hypoxia; Imidazoles; Losartan; Male; Meclofenamic Acid; Nitric Oxide; Pulmonary Artery; Pulmonary Circulation; Pyridines; Rats; Rats, Sprague-Dawley; Tetrazoles; Vasoconstriction | 1995 |
Characterization of angiotensin II receptor type 2 during differentiation and apoptosis of rat ovarian cultured granulosa cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Apoptosis; Biphenyl Compounds; Cell Differentiation; Cells, Cultured; DNA; Female; Follicle Stimulating Hormone; Granulosa Cells; Imidazoles; Kinetics; Losartan; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1995 |
Angiotensin AII AT1 receptor mediates ethanol-diazepam inhibition of hippocampal LTP.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Diazepam; Dose-Response Relationship, Drug; Ethanol; Hippocampus; Imidazoles; Long-Term Potentiation; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1994 |
Angiotensin II AT1 receptor mediated contraction of the perfused rat cerebral artery.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cerebral Arteries; Imidazoles; In Vitro Techniques; Losartan; Male; Oligopeptides; Perfusion; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles; Vasoconstriction | 1994 |
Evidence that angiotensin-(1-7) plays a role in the central control of blood pressure at the ventro-lateral medulla acting through specific receptors.
Topics: Analysis of Variance; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Imidazoles; Losartan; Male; Medulla Oblongata; Oligopeptides; Peptide Fragments; Rats; Rats, Wistar; Tetrazoles | 1994 |
Subtype 2 of angiotensin II receptors controls pressure-natriuresis in rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Diuresis; Glomerular Filtration Rate; Imidazoles; Losartan; Male; Natriuresis; Oligopeptides; Perfusion; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renal Circulation; Tetrazoles | 1995 |
Age-related changes in angiotensin II-stimulated vascular contraction and inositol phosphate accumulation in Fischer 344 rats.
Topics: Aging; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Arteries; Biphenyl Compounds; Imidazoles; In Vitro Techniques; Inositol Phosphates; Losartan; Male; Pyridines; Rats; Rats, Inbred F344; Receptors, Angiotensin; Tetrazoles; Vasoconstriction | 1994 |
Losartan, nonpeptide angiotensin II-type 1 (AT1) receptor antagonist, attenuates pressor and sympathoexcitatory responses evoked by angiotensin II and L-glutamate in rostral ventrolateral medulla.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Glutamic Acid; Hemodynamics; Imidazoles; Losartan; Male; Medulla Oblongata; Microinjections; Potassium; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Sympathetic Nervous System; Tetrazoles | 1994 |
Beta adrenoceptor blockade in rabbit inhibits the renin-releasing effect of AT1 receptor antagonist losartan.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atenolol; Biphenyl Compounds; Blood Pressure; Heart Rate; Imidazoles; Indomethacin; Losartan; Male; Rabbits; Renin; Tetrazoles | 1993 |
Regional haemodynamic responses to pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide in conscious rats.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Animals; Arginine; Biphenyl Compounds; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Imidazoles; Infusions, Intravenous; Losartan; Male; Neuropeptides; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pituitary Adenylate Cyclase-Activating Polypeptide; Propanolamines; Rats; Regional Blood Flow; Sodium Chloride; Tetrazoles; Vasoactive Intestinal Peptide | 1994 |
Mechanisms of angiotensin-induced hypotension and bradycardia in the medial solitary tract nucleus.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Bradycardia; Cardiovascular System; Glutamates; Glutamic Acid; Hypotension; Imidazoles; Losartan; Male; Medulla Oblongata; Microinjections; Oligopeptides; Rats; Rats, Sprague-Dawley; Tetrazoles; Vagus Nerve | 1994 |
Cloning of a rabbit kidney cortex AT1 angiotensin II receptor that is present in proximal tubule epithelium.
Topics: Amino Acid Sequence; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Base Sequence; Biphenyl Compounds; Blotting, Northern; Blotting, Southern; Cells, Cultured; Cloning, Molecular; DNA; Epithelial Cells; Epithelium; Imidazoles; Iodine Radioisotopes; Kidney Tubules, Proximal; Losartan; Molecular Sequence Data; Polymerase Chain Reaction; Protein Binding; Pyridines; Rabbits; Receptors, Angiotensin; Sequence Homology, Nucleic Acid; Tetrazoles; Transfection | 1993 |
Chronic effects of central and systemic administration of losartan on blood pressure and baroreceptor reflex in spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Heart Rate; Hypertension; Imidazoles; Injections, Intraventricular; Injections, Subcutaneous; Losartan; Male; Pressoreceptors; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reflex; Tetrazoles | 1994 |
Effects of angiotensin II AT1- or AT2-receptor antagonists on drinking evoked by angiotensin II or water deprivation in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Drinking; Heart Rate; Imidazoles; Injections, Intraventricular; Losartan; Male; Pyridines; Rats; Rats, Brattleboro; Tetrazoles; Water Deprivation | 1994 |
Tonic neuronal inhibition by AII revealed by iontophoretic application of Losartan, a specific antagonist of AII type-1 receptors.
Topics: Aldosterone; Amygdala; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Desoxycorticosterone; Imidazoles; Iontophoresis; Losartan; Male; Neurons; Preoptic Area; Prosencephalon; Rats; Rats, Wistar; Septum Pellucidum; Tetrazoles | 1994 |
The cardiac renin-angiotensin system in STZ-induced diabetes.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Diabetes Mellitus, Experimental; Gene Expression; Hyperglycemia; Imidazoles; Insulin; Kinetics; Losartan; Male; Myocardium; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Reference Values; Renin-Angiotensin System; RNA, Messenger; Tetrazoles | 1994 |
Telemetric blood pressure monitoring in benign 2-kidney, 1-clip renovascular hypertension: effect of chronic caffeine ingestion.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Caffeine; Captopril; Constriction; Heart Rate; Hypertension, Renovascular; Imidazoles; Kidney; Losartan; Male; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Telemetry; Tetrazoles | 1994 |
Modulation of renal vasoconstrictor effect of NG-nitro-L-arginine in rabbit by angiotensin II and alpha-1 adrenergic receptor blockade.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Antibodies; Arginine; Biphenyl Compounds; Drug Interactions; Hemodynamics; Hydralazine; Imidazoles; Kidney; Losartan; Male; Nitroarginine; Prazosin; Rabbits; Tetrazoles; Vasoconstrictor Agents | 1994 |
Regulation of the renal angiotensin II receptor gene in acute unilateral ureteral obstruction.
Topics: Acute Disease; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Down-Regulation; Gene Expression Regulation; Imidazoles; Kidney; Lisinopril; Losartan; Male; Rats; Rats, Wistar; Receptors, Angiotensin; RNA, Messenger; Tetrazoles; Ureteral Obstruction | 1994 |
Alterations in glomerular dynamics in congenital, unilateral hydronephrosis.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Fatty Acids, Unsaturated; Glomerular Filtration Rate; Hydrazines; Hydronephrosis; Imidazoles; Kidney Glomerulus; Losartan; Male; Rats; Rats, Inbred Strains; Rats, Wistar; Saralasin; Tetrazoles; Thromboxane A2 | 1994 |
Glomerular losartan (DuP 753)-sensitive angiotensin II receptor density is increased in young spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Hypertension; Imidazoles; In Vitro Techniques; Kidney Glomerulus; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Renin-Angiotensin System; Tetrazoles | 1994 |
Activation of AT1 angiotensin receptors induces DNA synthesis in a rat intestinal epithelial (RIE-1) cell line.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Base Sequence; Biphenyl Compounds; Blotting, Northern; Calcium; Cell Division; Cell Line; DNA; Enzyme Activation; Hydrolysis; Imidazoles; Intestinal Mucosa; Intestines; Losartan; Molecular Sequence Data; Phosphatidylinositols; Phosphorylation; Protein Kinase C; Pyridines; Rats; Receptors, Angiotensin; Tetrazoles | 1994 |
[125I]CGP 42112 reveals a non-angiotensin II binding site in 1-methyl-4-phenylpyridine (MPP+)-induced brain injury.
Topics: 1-Methyl-4-phenylpyridinium; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding Sites; Biphenyl Compounds; Brain; Brain Injuries; Imidazoles; Iodine Radioisotopes; Losartan; Male; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Substantia Nigra; Tetrazoles | 1994 |
Short-term desensitization of the angiotensin II receptor of bovine adrenal glomerulosa cells corresponds to a shift from a high to a low affinity state.
Topics: Aldosterone; Alkaloids; Angiotensin II; Animals; Biphenyl Compounds; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Imidazoles; Losartan; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Receptors, Angiotensin; Staurosporine; Tetrazoles; Time Factors; Zona Glomerulosa | 1994 |
Renal actions of the angiotensin AT2 receptor ligands CGP 42112 and PD 123319 after blockade of the renin-angiotensin system.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Enalaprilat; Imidazoles; Kidney; Losartan; Male; Oligopeptides; Pyridines; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Tetrazoles; Vascular Resistance | 1994 |
Enhanced pressor response to angiotensin III in spontaneously hypertensive rats: effects of losartan.
Topics: Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Hypertension; Imidazoles; Losartan; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazoles | 1994 |
Angiotensin II induces human placental lactogen and pregnancy-specific beta 1-glycoprotein secretion via an angiotensin AT1 receptor.
Topics: Angiotensin II; Biphenyl Compounds; Female; Humans; Imidazoles; Losartan; Oligopeptides; Placenta; Placental Lactogen; Pregnancy; Pregnancy-Specific beta 1-Glycoproteins; Receptors, Angiotensin; Tetrazoles; Trophoblasts | 1994 |
Dual effects of angiotensin II on calcium currents in neonatal rat nodose neurons.
Topics: Angiotensin II; Animals; Animals, Newborn; Biphenyl Compounds; Calcium Channel Blockers; Calcium Channels; Female; Imidazoles; In Vitro Techniques; Losartan; Male; Neurons; Nodose Ganglion; omega-Conotoxin GVIA; Peptides; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Tetrazoles; Virulence Factors, Bordetella | 1994 |
Time course of losartan blockade of angiotensin II hypertension versus blockade of angiotensin II fast pressor effects.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Brain Stem; Heart Rate; Hypertension; Imidazoles; Losartan; Male; Rats; Rats, Sprague-Dawley; Tetrazoles | 1994 |
Juxtaglomerular cell hypertrophy and hyperplasia induced in rhesus monkeys by angiotensin II receptor antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Enalapril; Hyperplasia; Hypertrophy; Imidazoles; Immunosuppressive Agents; Juxtaglomerular Apparatus; Losartan; Macaca mulatta; Pyridines; Renin; Tetrazoles; Time Factors | 1994 |
Properties of [3H]LF 7-0156, a new nonpeptide antagonist radioligand for the type 1 angiotensin II receptor.
Topics: Alkylating Agents; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Benzoates; Biphenyl Compounds; CHO Cells; Cricetinae; Female; Imidazoles; In Vitro Techniques; Inositol Phosphates; Kinetics; Liver; Losartan; Membranes; Oxidation-Reduction; Rabbits; Radioligand Assay; Recombinant Proteins; Sheep; Tetrazoles; Tritium | 1994 |
Angiotensin II AT2 receptor stimulation increases cerebrovascular resistance during hemorrhagic hypotension in rats.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Gas Analysis; Blood Pressure; Cerebral Cortex; Cerebral Hemorrhage; Dose-Response Relationship, Drug; Hypotension; Imidazoles; Infusions, Intravenous; Injections, Intravenous; Laser-Doppler Flowmetry; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Tetrazoles; Vascular Resistance | 1994 |
Rabbit renal epithelial angiotensin II receptors.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Biphenyl Compounds; Dithiothreitol; Dose-Response Relationship, Drug; Epithelium; Guanosine 5'-O-(3-Thiotriphosphate); Imidazoles; Iodine Radioisotopes; Kidney Cortex; Kinetics; Losartan; Male; Microvilli; Oligopeptides; Pyridines; Rabbits; Radioligand Assay; Receptors, Angiotensin; Tetrazoles | 1994 |
Effects of selective A1 receptor blockade on glomerular hemodynamics: involvement of renin-angiotensin system.
Topics: Adenosine; Analysis of Variance; Angiotensin II; Animals; Arterioles; Biphenyl Compounds; Blood Pressure; Capillaries; Glomerular Filtration Rate; Hematocrit; Hemodynamics; Imidazoles; Kidney Glomerulus; Losartan; Models, Cardiovascular; Muscle, Smooth, Vascular; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Reference Values; Regional Blood Flow; Renal Circulation; Renin-Angiotensin System; Tetrazoles; Vascular Resistance; Xanthines | 1994 |
Novel angiotensin receptor subtypes in fowl.
Topics: Acetylcholine; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Abdominal; Biphenyl Compounds; Blood Pressure; Cell Membrane; Chickens; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Imidazoles; In Vitro Techniques; Kinetics; Losartan; Models, Cardiovascular; Muscle Contraction; Muscle, Smooth, Vascular; Pyridines; Receptors, Angiotensin; Reserpine; Tetrazoles | 1994 |
Human cardiac fibroblasts express an angiotensin receptor with unusual binding characteristics which is coupled to cellular proliferation.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Cell Division; Cells, Cultured; Culture Media, Serum-Free; Fibroblasts; Heart Failure; Humans; Imidazoles; Kinetics; Losartan; Myocardium; Pyridines; Radioligand Assay; Receptors, Angiotensin; Tetrazoles | 1994 |
Blockade by intravenous losartan of AT1 angiotensin II receptors in rat brain, kidney and adrenals demonstrated by in vitro autoradiography.
Topics: Adrenal Glands; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Biphenyl Compounds; Blood-Brain Barrier; Brain Chemistry; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Injections, Intravenous; Kidney; Losartan; Male; Rats; Rats, Sprague-Dawley; Renin; Tetrazoles | 1994 |
Angiotensin II binding activity in cultured porcine arterial endothelial cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Binding Sites; Biphenyl Compounds; Cells, Cultured; Endothelium, Vascular; Imidazoles; Losartan; Pyridines; Swine; Tetrazoles | 1994 |
Intracerebroventricular administration of angiotensin II increases heart rate in the conscious trout.
Topics: Angiotensin II; Animals; Atropine; Biphenyl Compounds; Blood Pressure; Cerebral Ventricles; Consciousness; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Injections, Intra-Arterial; Injections, Intraventricular; Losartan; Tetrazoles; Trout | 1994 |
Role of the renin-angiotensin system in neointima formation after injury in rabbits.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Bradykinin; Heart Rate; Imidazoles; Indoles; Losartan; Male; Oligopeptides; Perindopril; Rabbits; Receptors, Angiotensin; Renin-Angiotensin System; Tetrazoles; Tunica Intima; Wound Healing | 1994 |
Characterization of PD 121981- and CGP 42112-induced unmasking of low concentration effects of angiotensin II in rabbit abdominal aorta.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Abdominal; Biphenyl Compounds; Calcium; Dithiothreitol; Female; Gallic Acid; Imidazoles; Losartan; Male; Nifedipine; Oligopeptides; Pyridines; Rabbits; Tetrazoles; Vasoconstriction | 1994 |
Vascular smooth-muscle cells contain AT1 angiotensin receptors coupled to phospholipase D activation.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Biphenyl Compounds; Calcium; Diglycerides; Enzyme Activation; Imidazoles; Kinetics; Losartan; Muscle, Smooth, Vascular; Oligopeptides; Peptide Fragments; Phospholipase D; Rats; Receptors, Angiotensin; Signal Transduction; Tetrazoles | 1994 |
Alterations in angiotensin II receptor mediated signal transduction shortly after coronary artery constriction in the rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Calcium-Transporting ATPases; Cells, Cultured; Constriction; Coronary Vessels; Cytosol; Dose-Response Relationship, Drug; Heart; Imidazoles; Losartan; Male; Myocardium; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Signal Transduction; Tetrazoles; Up-Regulation | 1994 |
Angiotensin II: endothelium-derived nitric oxide interaction in conscious rats.
Topics: Angiotensin II; Animals; Arginine; Biphenyl Compounds; Diet, Sodium-Restricted; Endothelium, Vascular; Hemodynamics; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Circulation; Renin; Tetrazoles | 1994 |
Effects of losartan (DuP753) and enalaprilat on the mean arterial pressure response to phenylephrine.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Enalaprilat; Heart Rate; Imidazoles; Infusions, Intravenous; Losartan; Phenylephrine; Rabbits; Renin-Angiotensin System; Tetrazoles | 1994 |
Role of angiotensin receptor subtypes in the response of rabbit brain arterioles to angiotensin.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arterioles; Biphenyl Compounds; Brain; Cerebrovascular Circulation; Imidazoles; Losartan; Male; Pyridines; Rabbits; Receptors, Angiotensin; Tetrazoles; Vasodilation | 1994 |
Angiotensin II stimulation of Na-H antiporter activity is cAMP independent in OKP cells.
Topics: Adenylate Cyclase Toxin; Angiotensin II; Animals; Biphenyl Compounds; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Imidazoles; Kidney; Losartan; Opossums; Pertussis Toxin; Sodium-Hydrogen Exchangers; Tetrazoles; Virulence Factors, Bordetella | 1994 |
Altered renal vascular responses in the aging rat kidney.
Topics: Aging; Angiotensin II; Animals; Arginine; Biphenyl Compounds; Blood Pressure; Endothelins; Glomerular Filtration Rate; Imidazoles; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Renal Circulation; Tetrazoles | 1994 |
Hypertrophic growth of cultured neonatal rat heart cells mediated by type 1 angiotensin II receptor.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Biphenyl Compounds; Calcium; Cardiomegaly; Cells, Cultured; Imidazoles; Intracellular Membranes; Losartan; Myocardium; Osmolar Concentration; Protein Biosynthesis; Protein Kinase C; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; RNA, Messenger; Tetrazoles | 1994 |
Modulation of autonomic nervous system adjustments to heat stress by central ANG II receptor antagonism.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine Vasopressin; Autonomic Nervous System; Biphenyl Compounds; Blood Pressure; Body Temperature; Brain; Heart Rate; Hot Temperature; Imidazoles; Injections, Intraventricular; Losartan; Male; Rats; Rats, Wistar; Stress, Physiological; Tetrazoles; Viscera | 1994 |
Angiotensins induce the release of prostacyclin from rabbit vas deferens: evidence for receptor heterogeneity.
Topics: 6-Ketoprostaglandin F1 alpha; Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Epoprostenol; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle, Smooth; Pyridines; Rabbits; Receptors, Angiotensin; Tetrazoles; Vas Deferens | 1994 |
Involvement of nitric oxide-formation in the action of losartan (DuP 753): effects in an inhibitory avoidance model.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine; Avoidance Learning; Biphenyl Compounds; Brain; Imidazoles; Losartan; Male; Mental Recall; Mice; Mice, Inbred Strains; Neural Inhibition; Nitric Oxide; Nitroarginine; Reaction Time; Receptors, Angiotensin; Tetrazoles | 1994 |
Angiotensin II 1 receptor-mediated contraction of pulmonary artery and its modulation by prolylcarboxypeptidase.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine; Biphenyl Compounds; Carboxypeptidases; Dogs; Endothelium, Vascular; Imidazoles; In Vitro Techniques; Isometric Contraction; Losartan; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Protease Inhibitors; Pulmonary Artery; Pyridines; Receptors, Angiotensin; Tetrazoles | 1994 |
Internalization of the rat AT1a and AT1b receptors: pharmacological and functional requirements.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biological Transport; Biphenyl Compounds; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Imidazoles; Losartan; Rats; Receptors, Angiotensin; Recombinant Proteins; Tetrazoles | 1994 |
Effect of angiotensin II type 1 receptor antagonist on urinary prostaglandin E2 excretion following furosemide in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Dinoprostone; Furosemide; Imidazoles; Indans; Losartan; Male; Prodrugs; Rats; Rats, Wistar; Tetrazoles | 1994 |
Inhibitory effect of dithiothreitol on angiotensin II-induced contractions mediated by AT1-receptors in rat portal vein and rabbit aorta.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Benzimidazoles; Binding Sites; Biphenyl Compounds; Dithiothreitol; Dose-Response Relationship, Drug; Imidazoles; Losartan; Male; Methylurea Compounds; Muscle Contraction; Muscle, Smooth, Vascular; Portal Vein; Rabbits; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles | 1994 |
Effect of losartan and enalapril on renal adaptation sodium restriction in rat.
Topics: Adaptation, Physiological; Aldosterone; Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Diet, Sodium-Restricted; Enalapril; Hemodynamics; Imidazoles; Kallikreins; Kidney; Losartan; Male; Natriuresis; Rats; Rats, Sprague-Dawley; Renal Circulation; Renin-Angiotensin System; Systole; Tetrazoles | 1994 |
Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding Sites; Biphenyl Compounds; Cardiomegaly; Hemodynamics; Imidazoles; Losartan; Male; Myocardium; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Reference Values; Tetrazoles; Tissue Distribution | 1994 |
Angiotensin II receptor subtypes in bovine and human ventricular myocardium.
Topics: Aged; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cattle; Dithiothreitol; Heart Ventricles; Humans; Imidazoles; Iodine Radioisotopes; Losartan; Male; Myocardium; Pyridines; Radioligand Assay; Receptors, Angiotensin; Tetrazoles | 1994 |
AT1 receptor characteristics of angiotensin analogue binding in human synovium.
Topics: Adult; Aged; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Arthritis, Rheumatoid; Autoradiography; Biphenyl Compounds; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Imidazoles; Immunohistochemistry; In Vitro Techniques; Iodine Radioisotopes; Ligands; Losartan; Male; Middle Aged; Osteoarthritis; Pyridines; Receptors, Angiotensin; Synovial Fluid; Tetrazoles | 1994 |
Effect of sodium chloride, enalapril, and losartan on the development of polycystic kidney disease in Han:SPRD rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Body Weight; Creatinine; Enalapril; Female; Imidazoles; Losartan; Male; Polycystic Kidney Diseases; Rats; Rats, Sprague-Dawley; Renin; Sodium Chloride; Tetrazoles | 1994 |
Endogenous angiotensin II enhances phenylephrine-induced tone in hypertensive rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Hypertension; Imidazoles; Indoles; Losartan; Mesenteric Arteries; Phenylephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Regional Blood Flow; Tetrazoles; Vasomotor System | 1994 |
Angiotensin II exerts differential actions on renal nerve activity and heart rate.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Baroreflex; Biphenyl Compounds; Blood Pressure; Heart Rate; Imidazoles; Infusions, Intravenous; Kidney; Losartan; Male; Phenylephrine; Pressoreceptors; Rabbits; Receptors, Angiotensin; Sympathetic Nervous System; Tetrazoles | 1994 |
Effects of angiotensin II and angiotensin-(1-7) on the release of [3H]norepinephrine from rat atria.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Drug Interactions; Electric Stimulation; Female; Heart; Heart Atria; Imidazoles; Losartan; Myocardium; Norepinephrine; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Saralasin; Tetrazoles | 1994 |
Modification of pressure natriuresis by long-term losartan in spontaneously hypertensive rats.
Topics: Administration, Oral; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Body Weight; Drug Administration Schedule; Glomerular Filtration Rate; Hypertension; Imidazoles; Kidney; Losartan; Male; Natriuresis; Random Allocation; Rats; Rats, Inbred SHR; Renal Artery; Renal Circulation; Tetrazoles | 1994 |
Comparison of fos-like immunoreactivity induced in rat brain by central injection of angiotensin II and carbachol.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Brain; Carbachol; Imidazoles; Immunohistochemistry; Injections, Intraventricular; Losartan; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Tetrazoles | 1994 |
Receptor subtype that mediates the neuronal effects of angiotensin II in the rat dorsal medulla.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Electrophysiology; Glutamates; Glutamic Acid; Imidazoles; In Vitro Techniques; Losartan; Medulla Oblongata; Neurons; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1993 |
Positive inotropic action of angiotensin II in the pithed rat.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Decerebrate State; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Losartan; Male; Myocardial Contraction; Pyridines; Rats; Rats, Wistar; Stimulation, Chemical; Tetrazoles | 1993 |
Subfornical organ efferents to paraventricular nucleus utilize angiotensin as a neurotransmitter.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Efferent Pathways; Electric Stimulation; Imidazoles; Losartan; Male; Neurons; Neurotransmitter Agents; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Subfornical Organ; Tetrazoles | 1993 |
Prevention of thromboxane A2 receptor-mediated pulmonary hypertension by a nonpeptide angiotensin II type 1 receptor antagonist.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Enalapril; Fatty Acids, Unsaturated; Hematocrit; Hydrazines; Hypertension, Pulmonary; Imidazoles; Losartan; Male; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Tetrazoles; Thromboxane A2 | 1994 |
Stimulatory effect of angiotensin II on the proliferation of mouse spleen lymphocytes in vitro is mediated via both types of angiotensin II receptors.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Imidazoles; Losartan; Lymphocyte Activation; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Pyridines; Receptors, Angiotensin; Spleen; Tetrazoles; Thymidine | 1994 |
[Angiotensin II receptors in the heart conduction tissue].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atrioventricular Node; Biphenyl Compounds; Heart Conduction System; Histocytochemistry; Imidazoles; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Sinoatrial Node; Tetrazoles; Tissue Distribution | 1993 |
Role of angiotensin AT1 receptor in the cardiovascular response to footshock.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Electroshock; Heart Rate; Hemodynamics; Imidazoles; Losartan; Male; Norepinephrine; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1994 |
Role of anterior hypothalamic angiotensin II in the pathogenesis of salt sensitive hypertension in the spontaneously hypertensive rat.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Cells, Cultured; Hypertension; Hypothalamus, Anterior; Imidazoles; Losartan; Male; Microinjections; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Sodium Chloride; Tetrazoles | 1994 |
Effects of LHRH and ANG II on prolactin stimulation are mediated by hypophysial AT1 receptor subtype.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Female; Gonadotropin-Releasing Hormone; Imidazoles; In Vitro Techniques; Losartan; Perfusion; Pituitary Gland; Prolactin; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1994 |
Kinins contribute to the improvement of insulin sensitivity during treatment with angiotensin converting enzyme inhibitor.
Topics: Analysis of Variance; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Glucose; Blood Pressure; Body Weight; Bradykinin; Doxazosin; Enalapril; Glucose Clamp Technique; Hypertension; Imidazoles; Insulin; Kinins; Losartan; Male; Potassium; Rats; Rats, Inbred SHR; Sodium; Tetrazoles | 1994 |
Ontogeny of angiotensin-II-induced prolactin release in vivo and in vitro in female and male rats.
Topics: Aging; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Female; Imidazoles; In Vitro Techniques; Losartan; Male; Pituitary Gland; Prolactin; Pyridines; Rats; Rats, Sprague-Dawley; Tetrazoles; Time Factors | 1994 |
Synthetic cDNA encoding the rat AT1a receptor: a useful tool for structure-function relationship analysis.
Topics: Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Base Sequence; Biphenyl Compounds; CHO Cells; Codon; Cricetinae; DNA, Complementary; Imidazoles; Kinetics; Losartan; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Oligopeptides; Open Reading Frames; Pyridines; Rats; Receptors, Angiotensin; Restriction Mapping; Saralasin; Signal Transduction; Structure-Activity Relationship; Tetrazoles; Transfection | 1994 |
Effect of SR 47436, a novel angiotensin II AT1 receptor antagonist, on human vascular smooth muscle cells in vitro.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Calcium; Cell Division; Cells, Cultured; Humans; Imidazoles; Iodine Radioisotopes; Irbesartan; Losartan; Mitogens; Muscle, Smooth, Vascular; Protein Binding; Tetrazoles | 1994 |
Identification of AT1 receptors on human platelets and decreased angiotensin II binding in hypertension.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Binding, Competitive; Biphenyl Compounds; Blood Platelets; Humans; Hypertension; Imidazoles; In Vitro Techniques; Kinetics; Losartan; Middle Aged; Oligopeptides; Receptors, Angiotensin; Tetrazoles | 1993 |
Differential regulation of angiotensin II and losartan binding sites in glomeruli and mesangial cells.
Topics: Administration, Oral; Angiotensin II; Animals; Binding Sites; Biphenyl Compounds; Glomerular Mesangium; Imidazoles; In Vitro Techniques; Kidney Glomerulus; Losartan; Male; Rats; Rats, Wistar; Receptors, Angiotensin; RNA, Messenger; Saralasin; Tetrazoles | 1994 |
Altered pressure natriuresis in chronic angiotensin II hypertension in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Chronic Disease; Hypertension; Imidazoles; Losartan; Male; Natriuresis; Rats; Rats, Sprague-Dawley; Reference Values; Tetrazoles | 1994 |
Angiotensin II-mediated pressor effect of rat joining peptide.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Captopril; Dose-Response Relationship, Drug; Imidazoles; Injections, Intravenous; Losartan; Male; Peptide Fragments; Peptides; Pro-Opiomelanocortin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sympatholytics; Tetrazoles | 1994 |
A non-competitive type of angiotensin-receptor antagonism by losartan in renal artery preparations.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Losartan; Muscle Contraction; Muscle, Smooth, Vascular; Pyridines; Rabbits; Renal Artery; Tetrazoles; Vasoconstriction | 1994 |
Molecular cloning of the canine angiotensin II receptor. An AT1-like receptor with reduced affinity for DuP753.
Topics: Amino Acid Sequence; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Base Sequence; Biphenyl Compounds; Cell Line; Cloning, Molecular; DNA; Dogs; Humans; Imidazoles; In Vitro Techniques; Losartan; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth, Vascular; Rabbits; Receptors, Angiotensin; Sequence Homology, Amino Acid; Tetrazoles | 1994 |
Intravenous losartan inhibits the increase in plasma luteinizing hormone and water intake produced by intraventricular angiotensin II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Drinking; Female; Imidazoles; Injections, Intravenous; Injections, Intraventricular; Losartan; Luteinizing Hormone; Rats; Rats, Sprague-Dawley; Tetrazoles | 1994 |
Angiotensin receptor regulates cardiac hypertrophy and transforming growth factor-beta 1 expression.
Topics: Angiotensin II; Animals; Aortic Coarctation; Atrial Natriuretic Factor; Biphenyl Compounds; Cardiomegaly; Gene Expression Regulation; Imidazoles; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles; Transforming Growth Factor beta | 1994 |
Analysis of angiotensins I, II, and III in pulmonary vascular bed of the rat.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Blood Vessels; Captopril; Enalaprilat; Imidazoles; In Vitro Techniques; Losartan; Male; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Tetrazoles | 1994 |
Involvement of angiotensin receptor subtypes in osmotically induced release of vasopressin.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine Vasopressin; Biphenyl Compounds; Imidazoles; Injections, Intraventricular; Losartan; Male; Oligopeptides; Osmolar Concentration; Pyridines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Saline Solution, Hypertonic; Tetrazoles | 1994 |
Thirst induced by increasing brain sodium concentration is mediated by brain angiotensin.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Brain Chemistry; Cattle; Dehydration; Drinking; Female; Imidazoles; Injections, Intraventricular; Losartan; Male; Mice; Mice, Inbred BALB C; Rabbits; Rats; Rats, Sprague-Dawley; Saline Solution, Hypertonic; Sheep; Sodium; Tetrazoles; Thirst | 1994 |
Comparative effects of chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on cardiac remodeling after myocardial infarction in the rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Coronary Circulation; Enalapril; Hypertrophy, Left Ventricular; Imidazoles; Losartan; Male; Myocardial Infarction; Myocardium; Rats; Rats, Sprague-Dawley; Tetrazoles; Time Factors | 1994 |
Mechanisms of hypertension in transgenic rats expressing the mouse Ren-2 gene.
Topics: Angiotensin II; Animals; Animals, Genetically Modified; Antihypertensive Agents; Arginine; Biphenyl Compounds; Blood Pressure; Endothelins; Female; Gene Expression; Hemodynamics; Hypertension; Imidazoles; Lisinopril; Losartan; Mice; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Reference Values; Tetrazoles | 1994 |
Selective changes in angiotensin II AT1 and AT2 receptor subtypes in the rat superior colliculus following eye enucleation.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Biphenyl Compounds; Eye Enucleation; Geniculate Bodies; Imidazoles; Iodine Radioisotopes; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Retina; Saralasin; Subcellular Fractions; Superior Colliculi; Suprachiasmatic Nucleus; Synapses; Tetrazoles; Visual Pathways | 1994 |
Modulation of tachyphylaxis to angiotensin II in rabbit isolated aorta by the angiotensin AT1 receptor antagonist, losartan.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Biphenyl Compounds; Drug Interactions; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Rabbits; Reproducibility of Results; Tachyphylaxis; Tetrazoles | 1994 |
The effect of losartan on potassium-stimulated aldosterone secretion in vitro.
Topics: Aldosterone; Angiotensin II; Animals; Biphenyl Compounds; Female; Imidazoles; Losartan; Periodicity; Potassium; Rats; Rats, Sprague-Dawley; Tetrazoles; Zona Glomerulosa | 1994 |
Angiotensin II and alpha 1-adrenergic tone in chronic nitric oxide blockade-induced hypertension.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine; Biphenyl Compounds; Blood Pressure; Glomerular Filtration Rate; Hematocrit; Hypertension; Imidazoles; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Angiotensin; Reference Values; Regional Blood Flow; Renal Circulation; Tetrazoles; Vascular Resistance | 1994 |
Angiotensin II alters aortic fibronectin independently of hypertension.
Topics: Angiotensin II; Animals; Aorta; Biphenyl Compounds; Blood Pressure; Fibronectins; Humans; Hydralazine; Hypertension; Imidazoles; Losartan; Male; Prazosin; Rats; Rats, Wistar; RNA, Messenger; Tetrazoles | 1994 |
Losartan inhibits sympathetic and cardiovascular responses to carotid occlusion.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Cardiovascular System; Carotid Arteries; Constriction; Heart Rate; Imidazoles; Kidney; Losartan; Nitroprusside; Phenylephrine; Rabbits; Sympathetic Nervous System; Tetrazoles | 1994 |
In vivo occupancy of angiotensin II subtype 1 receptors in rat renal medullary interstitial cells.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Biphenyl Compounds; Imidazoles; In Vitro Techniques; Kidney Medulla; Losartan; Male; Microscopy, Electron; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1994 |
Effects of angiotensin receptor subtype inhibitors on plasma angiotensin clearance.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Imidazoles; Losartan; Male; Metabolic Clearance Rate; Pyridines; Rats; Rats, Sprague-Dawley; Tetrazoles | 1994 |
Differential structural requirements for specific binding of nonpeptide and peptide antagonists to the AT1 angiotensin receptor. Identification of amino acid residues that determine binding of the antihypertensive drug losartan.
Topics: Amino Acid Sequence; Angiotensin II; Angiotensins; Animals; Binding Sites; Binding, Competitive; Biphenyl Compounds; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Imidazoles; Kidney; Kinetics; Losartan; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Rats; Receptors, Angiotensin; Recombinant Proteins; Tetrazoles | 1994 |
The reduction in alcohol drinking by peripherally injected angiotensin II is selectively mediated by the AT1 receptor subtype.
Topics: Alcohol Drinking; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Drinking; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles | 1994 |
The neurogenic origin of hypertension in SHR may be mediated by angiotensin II through a receptor different from AT1 and AT2.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Hypertension; Imidazoles; Injections, Intraventricular; Losartan; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Tetrazoles | 1993 |
Angiotensin II is the mediator of the increase in hepatic angiotensinogen synthesis after bilateral nephrectomy.
Topics: Adrenalectomy; Angiotensin II; Angiotensinogen; Animals; Atenolol; Biphenyl Compounds; Imidazoles; Kidney; Liver; Losartan; Male; Nephrectomy; Osmolar Concentration; Postoperative Period; Rats; Rats, Wistar; Renin; Tetrazoles; Time Factors | 1993 |
Cardiovascular consequences of microinjection of vasopressin and angiotensin II in the area postrema.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Cardiovascular System; Cerebral Ventricles; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Injections, Intraventricular; Losartan; Male; Microinjections; Rats; Rats, Sprague-Dawley; Tetrazoles; Vasopressins | 1993 |
Regional haemodynamic effects of angiotensin II (3-8) in conscious rats.
Topics: Amino Acid Sequence; Angiotensin II; Angiotensin III; Animals; Arginine; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Hindlimb; Imidazoles; In Vitro Techniques; Losartan; Male; Molecular Sequence Data; Rats; Regional Blood Flow; Renal Circulation; Splanchnic Circulation; Tetrazoles | 1993 |
A facilitatory effect of anti-angiotensin drugs on vagal bradycardia in the pithed rat and guinea-pig.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Bronchoconstriction; Captopril; Decerebrate State; Electric Stimulation; Guinea Pigs; Heart; Heart Rate; Imidazoles; In Vitro Techniques; Losartan; Male; Methacholine Compounds; Nephrectomy; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Tetrazoles; Tubocurarine; Vagus Nerve | 1993 |
[Angiotensin receptors in the rat myocardium during pre- and postnatal development].
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Biphenyl Compounds; Heart; Imidazoles; Ligands; Losartan; Male; Myocardium; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1993 |
Angiotensin II increases norepinephrine release from atria by acting on angiotensin subtype 1 receptors.
Topics: Analysis of Variance; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Guinea Pigs; Heart; Heart Atria; Imidazoles; In Vitro Techniques; Kinetics; Losartan; Male; Myocardium; Norepinephrine; Ramipril; Receptors, Angiotensin; Tetrazoles | 1993 |
Mechanism of ochratoxin A-induced reduction of glomerular filtration rate in rats.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Glomerular Filtration Rate; Glycosuria; Hemodynamics; Imidazoles; Kidney Tubules; Losartan; Male; Ochratoxins; Proteinuria; Rats; Rats, Wistar; Receptors, Angiotensin; Renal Circulation; Tetrazoles | 1993 |
Human aortic smooth muscle cells containing angiotensin II type 1 receptors.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Calcium; Cells, Cultured; Humans; Imidazoles; Losartan; Membranes; Muscle, Smooth, Vascular; Pyridines; Receptors, Angiotensin; Tetrazoles | 1993 |
Angiotensin II type 1 receptor-mediated stimulation of c-fos gene expression in astroglial cultures.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Astrocytes; Biphenyl Compounds; Dose-Response Relationship, Drug; Gene Expression; Genes, fos; Imidazoles; Losartan; Pyridines; Rats; Receptors, Angiotensin; RNA, Messenger; Tetrazoles | 1993 |
Interactions of adenosine A1 receptor-mediated renal vasoconstriction with endogenous nitric oxide and ANG II.
Topics: Adenine; Adenosine; Angiotensin II; Animals; Arginine; Arginine Vasopressin; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine; Purinergic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Regional Blood Flow; Renal Circulation; Serotonin; Tetrazoles; Thromboxane A2; Vascular Resistance; Vasoconstriction | 1993 |
Modulation of ANG II receptor and its mRNA in normal rat by low-protein feeding.
Topics: Analysis of Variance; Angiotensin II; Animals; Antihypertensive Agents; Autoradiography; Biphenyl Compounds; Blood Pressure; Blotting, Northern; Dietary Proteins; Glomerular Filtration Rate; Imidazoles; In Situ Hybridization; Iodine Radioisotopes; Kidney; Kidney Cortex; Kidney Glomerulus; Kinetics; Losartan; Male; Rats; Rats, Wistar; Receptors, Angiotensin; Reference Values; Regional Blood Flow; Renal Circulation; Renin; RNA, Messenger; Tetrazoles; Vascular Resistance | 1993 |
Renin-angiotensin system and minoxidil-induced cardiac hypertrophy in rats.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Cardiomegaly; Enalapril; Heart; Hemodynamics; Imidazoles; Losartan; Male; Minoxidil; Rats; Rats, Wistar; Renin; Renin-Angiotensin System; Tetrazoles; Ventricular Function, Left | 1993 |
Angiotensin II and non-angiotensin II displaceable binding sites for [3H]losartan in the rat liver.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding Sites; Binding, Competitive; Biphenyl Compounds; Imidazoles; Liver; Losartan; Male; Rats; Receptors, Angiotensin; Subcellular Fractions; Tetrazoles; Tritium | 1993 |
Angiotensin II receptor isoforms in the rat adrenal gland: studies with the selective subtype antagonists DuP 753 and CGP42112A.
Topics: Adrenal Glands; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding, Competitive; Biphenyl Compounds; Imidazoles; Iodine Radioisotopes; Isoelectric Focusing; Kinetics; Losartan; Male; Oligopeptides; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles | 1993 |
Identification and characterization of angiotensin-II receptor subtypes in cultured bovine and human adrenal fasciculata cells and PC12W cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Biphenyl Compounds; Cattle; Cells, Cultured; Chemical Phenomena; Chemistry, Physical; Cross-Linking Reagents; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Humans; Imidazoles; Losartan; Macromolecular Substances; Oligopeptides; PC12 Cells; Receptors, Angiotensin; Tetrazoles; Zona Fasciculata | 1993 |
Antagonist effect of losartan on angiotensin II induced contraction in five isolated smooth muscle assays.
Topics: Angiotensin II; Animals; Aorta; Biphenyl Compounds; Guinea Pigs; Ileum; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Rabbits; Stomach; Tetrazoles; Trachea | 1993 |
(Dipropylphenoxy)phenylacetic acids: a new generation of nonpeptide angiotensin II receptor antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Biphenyl Compounds; Blood Pressure; Brain; Imidazoles; Losartan; Phenylacetates; Rabbits; Rats; Receptors, Angiotensin; Tetrazoles | 1993 |
Renal responses to acute angiotensin II inhibition and administered angiotensin II in the aging, conscious, chronically catheterized rat.
Topics: Age Factors; Aging; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Hemodynamics; Imidazoles; Kidney; Losartan; Male; Rats; Rats, Sprague-Dawley; Renal Plasma Flow; Tetrazoles | 1993 |
Mechanical strain and collagen potentiate mitogenic activity of angiotensin II in rat vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Biphenyl Compounds; Cell Division; Cells, Cultured; Collagen; DNA; Drug Synergism; Fibronectins; Gelatin; Imidazoles; Losartan; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Ramipril; Rats; Recombinant Proteins; Stress, Mechanical; Tetrazoles; Thymidine | 1993 |
Characterization of putative glomerular receptors for angiotensin II in the rainbow trout Oncorhynchus mykiss using the antagonists Losartan, PD 123177, and saralasin.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Imidazoles; Iodine Radioisotopes; Kidney Glomerulus; Kinetics; Losartan; Oncorhynchus mykiss; Pyridines; Receptors, Angiotensin; Saralasin; Tetrazoles | 1993 |
Role of angiotensin II in brown adipose thermogenesis during cold acclimation.
Topics: Acclimatization; Adipose Tissue, Brown; Angiotensin II; Animals; Biphenyl Compounds; Body Temperature Regulation; Cold Temperature; Imidazoles; In Vitro Techniques; Losartan; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Renin; Synapses; Systole; Tetrazoles; Tritium | 1993 |
Immunological reactivity of angiotensin II receptor antagonists: possible implications for receptor binding sites.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antibodies, Monoclonal; Antihypertensive Agents; Biphenyl Compounds; Imidazoles; In Vitro Techniques; Indicators and Reagents; Iodine Radioisotopes; Losartan; Molecular Conformation; Oligopeptides; Pyridines; Rats; Receptors, Angiotensin; Saralasin; Tetrazoles | 1993 |
Renal actions of the selective angiotensin AT2 receptor ligands CGP 42112B and PD 123319 in the sodium-depleted rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Diet, Sodium-Restricted; Glomerular Filtration Rate; Imidazoles; Kidney; Losartan; Male; Oligopeptides; Potassium; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Renal Circulation; Sodium; Tetrazoles; Vascular Resistance | 1993 |
Role of the lipoxygenase pathway in angiotensin II-induced vascular smooth muscle cell hypertrophy.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Biphenyl Compounds; Cells, Cultured; Dose-Response Relationship, Drug; Fibronectins; Flavanones; Flavonoids; Hydroxyeicosatetraenoic Acids; Hypertrophy; Ibuprofen; Imidazoles; Lipoxygenase Inhibitors; Losartan; Muscle, Smooth, Vascular; Pyridines; Swine; Tetrazoles | 1994 |
Pressor mechanisms in adriamycin-induced nephropathy with hypertension in rats.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Cholesterol; Creatinine; Doxorubicin; Hypertension; Imidazoles; Kidney; Kidney Failure, Chronic; Losartan; Male; Nephrotic Syndrome; Potassium; Rats; Rats, Wistar; Serum Albumin; Sodium; Tetrazoles; Time Factors; Urea; Vasopressins | 1994 |
Oxytocic effect of trypsin on the isolated rat uterus.
Topics: Angiotensin I; Angiotensin II; Animals; Biphenyl Compounds; Bradykinin; Dose-Response Relationship, Drug; Enalaprilat; Female; Imidazoles; In Vitro Techniques; Isometric Contraction; Losartan; Oxytocin; Pepstatins; Rats; Saralasin; Tetrazoles; Trypsin; Uterine Contraction; Uterus | 1994 |
DuP 753 is more effective than captopril on baroreceptor function in high-renin hypertension.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Captopril; Heart Rate; Hypertension; Imidazoles; Losartan; Male; Phenylephrine; Pressoreceptors; Rats; Rats, Wistar; Reflex; Renin; Tetrazoles; Time Factors | 1994 |
Chronic converting enzyme inhibition facilitates baroreceptor resetting to hypertensive levels.
Topics: Angiotensin I; Angiotensin II; Animals; Aorta; Biphenyl Compounds; Blood Pressure; Bradykinin; Captopril; Enalapril; Hypertension; Imidazoles; Losartan; Male; Pressoreceptors; Rats; Rats, Wistar; Reference Values; Regression Analysis; Tetrazoles | 1994 |
Angiotensin receptor sites in renal vasculature of rats developing genetic hypertension.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Biphenyl Compounds; Blood Vessels; Hemodynamics; Hypertension; Imidazoles; Losartan; Microcirculation; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Renal Circulation; Tetrazoles; Vasoconstriction | 1993 |
Segmental differences in angiotensin receptor subtypes in interlobular artery of hydronephrotic rat kidneys.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arteries; Biphenyl Compounds; Hydronephrosis; Imidazoles; In Vitro Techniques; Losartan; Male; Perfusion; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renal Circulation; Tetrazoles; Vasoconstriction | 1993 |
Angiotensin II: nitric oxide interaction and the distribution of blood flow.
Topics: Angiotensin II; Animals; Arginine; Biphenyl Compounds; Blood Circulation; Blood Pressure; Cardiac Output; Heart Rate; Hemodynamics; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Tetrazoles; Vascular Resistance | 1993 |
Contribution of angiotensin II to renal hemodynamic and excretory responses to nitric oxide synthesis inhibition in the rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine; Biphenyl Compounds; Blood Pressure; Glomerular Filtration Rate; Imidazoles; Kidney; Losartan; Male; Natriuresis; Nitric Oxide; Nitroarginine; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renal Circulation; Tetrazoles | 1993 |
Imidazole based non-peptide angiotensin II receptor antagonists. Investigation of the effect of the orientation of the imidazole ring on biological activity.
Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Female; Imidazoles; In Vitro Techniques; Losartan; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tetrazoles; Thiophenes; Uterine Contraction | 1993 |
Comparison of the effects of EXP3174, an angiotensin II antagonist and enalaprilat on myocardial infarct size in anaesthetized dogs.
Topics: Anesthesia; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Coronary Circulation; Disease Models, Animal; Dogs; Enalaprilat; Female; Furosemide; Heart Rate; Imidazoles; Injections, Intravenous; Losartan; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Renin-Angiotensin System; Tetrazoles | 1993 |
Pharmacological study of SR 47436, a non-peptide angiotensin II AT1-receptor antagonist, in conscious monkeys.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Female; Imidazoles; Irbesartan; Losartan; Macaca fascicularis; Male; Renin; Sodium, Dietary; Tetrazoles | 1993 |
The effect of the putative AT2 agonist, p-aminophenylalanine6 angiotensin II, on thirst and sodium appetite in rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Appetite; Biphenyl Compounds; Drinking; Imidazoles; Injections, Intraventricular; Losartan; Male; Oligopeptides; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Sodium Chloride, Dietary; Tetrazoles; Thirst | 1993 |
[The role of G-regulatory proteins in the intracellular mechanism of cardiac angiotensin-II receptors].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding, Competitive; Biphenyl Compounds; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Heart; Imidazoles; Losartan; Male; Myocardium; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1993 |
Losartan: An Orally Active Angiotensin II Antagonist. Proceedings of a meeting. Saint Paul de Vence, France, 26-27 June 1992.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Humans; Imidazoles; Losartan; Tetrazoles | 1993 |
Effects of EXP3174, a non-peptide angiotensin II receptor antagonist, on renal hemodynamics and renal function in dogs.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Body Water; Dogs; Glomerular Filtration Rate; Heart Rate; Imidazoles; Infusions, Intra-Arterial; Kidney; Kidney Function Tests; Losartan; Renal Circulation; Sodium; Tetrazoles | 1993 |
Dup 753 prevents the development of puromycin aminonucleoside-induced nephrosis.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Urea Nitrogen; Cholesterol; Imidazoles; Losartan; Male; Nephrosis; Puromycin Aminonucleoside; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Tetrazoles | 1993 |
Effect of angiotensin II blockade on dietary protein-induced renal growth.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Dietary Proteins; Enalapril; Hypertrophy; Imidazoles; Kidney; Losartan; Male; Organ Size; Rats; Rats, Sprague-Dawley; Tetrazoles | 1993 |
Endothelin modulates angiotensin II-induced mitogenesis of human mesangial cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Cell Division; Cells, Cultured; Endothelins; Glomerular Mesangium; Humans; Imidazoles; Insulin; Losartan; Mitogens; Tetrazoles | 1993 |
Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes.
Topics: Angiotensin II; Animals; Base Sequence; Biphenyl Compounds; Cardiomegaly; Cells, Cultured; Endothelin Receptor Antagonists; Endothelins; Gene Expression; Imidazoles; In Vitro Techniques; Losartan; Molecular Sequence Data; Muscle Proteins; Myocardium; Oligodeoxyribonucleotides; Oligonucleotides, Antisense; Peptides, Cyclic; Rats; Rats, Wistar; RNA, Messenger; Tetrazoles | 1993 |
Role of angiotensin II and AT1 receptors in hippocampal LTP.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Diazepam; Electric Stimulation; Electrophysiology; Ethanol; Hippocampus; Imidazoles; Learning; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Saralasin; Tetrazoles | 1993 |
Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethy
Topics: Adrenal Cortex; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cattle; Imidazoles; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Prodrugs; Protein Binding; Rabbits; Rats; Rats, Sprague-Dawley; Substrate Specificity; Tetrazoles | 1993 |
Effects of blockade of AT1 and AT2 receptors in brain on the central angiotensin II pressor response in conscious spontaneously hypertensive rats.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Brain; Heart Rate; Hypertension; Imidazoles; Injections, Intraventricular; Losartan; Male; Rats; Rats, Inbred SHR; Receptors, Angiotensin; Tetrazoles; Vascular Resistance | 1993 |
Autoradiographic characterization of angiotensin II receptor subtypes in rat intestine.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Biphenyl Compounds; Imidazoles; Intestinal Mucosa; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles; Tissue Distribution | 1993 |
Angiotensin subtype 1 blockade selectively potentiates adenosine subtype 2-mediated vasodilation.
Topics: Adenosine; Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Heart Rate; Imidazoles; Injections, Intravenous; Losartan; Male; Nifedipine; Nitroglycerin; Rats; Rats, Sprague-Dawley; Tetrazoles; Vascular Resistance; Vasodilation | 1993 |
Renal nitric oxide and angiotensin II interaction in renovascular hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Arginine; Biphenyl Compounds; Endothelium, Vascular; Hemodynamics; Hypertension, Renovascular; Imidazoles; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Circulation; Tetrazoles | 1993 |
Differential blockade of central effects of angiotensin II by AT2-receptor antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Brain; Cardiovascular System; Imidazoles; Injections, Intraventricular; Losartan; Male; Pyridines; Rats; Tetrazoles | 1993 |
Regulation of the urinary excretion of endothelin in the rat.
Topics: Analysis of Variance; Angiotensin II; Animals; Antihypertensive Agents; Arginine Vasopressin; Biphenyl Compounds; Blood Pressure; Captopril; Dose-Response Relationship, Drug; Endothelins; Glomerular Filtration Rate; Imidazoles; Kidney; Losartan; Male; Nifedipine; Radioimmunoassay; Rats; Rats, Wistar; Saralasin; Tetrazoles | 1993 |
Angiotensin II receptors in the rat urinary bladder smooth muscle: type 1 subtype receptors mediate contractile responses.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Biphenyl Compounds; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle Contraction; Muscle, Smooth; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles; Urinary Bladder | 1993 |
Alterations in vascular structure and function after short-term losartan treatment in spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Hydralazine; Hypertension; Imidazoles; Losartan; Male; Muscle, Smooth, Vascular; Rats; Rats, Inbred SHR; Tetrazoles; Vasoconstriction | 1993 |
Binding of angiotensin antagonists to rat liver and brain membranes measured ex vivo.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Biphenyl Compounds; Blood-Brain Barrier; Brain; Imidazoles; In Vitro Techniques; Iodine Radioisotopes; Liver; Losartan; Male; Membranes; Nicotinic Acids; Pyridines; Rats; Receptors, Angiotensin; Saralasin; Tetrazoles | 1993 |
Role of intrarenal ANG II in reflex neural stimulation of plasma renin activity and renal sodium reabsorption.
Topics: Absorption; Angiotensin II; Animals; Biphenyl Compounds; Blood Volume; Captopril; Dogs; Female; Hemodynamics; Imidazoles; Kidney; Losartan; Male; Reflex; Renal Circulation; Renin; Sodium; Sympathetic Nervous System; Tetrazoles; Vasoconstriction | 1993 |
Control of blood pressure and end-organ damage in maturing salt-loaded stroke-prone spontaneously hypertensive rats by oral angiotensin II receptor blockade.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Proteins; Body Weight; Brain; Chlorides; Creatinine; Diuresis; Hypertension; Imidazoles; Kidney; Losartan; Male; Myocardium; Organ Size; Osmolar Concentration; Potassium; Proteinuria; Rats; Rats, Inbred SHR; Renin; Renin-Angiotensin System; Sodium; Tetrazoles | 1993 |
Angiotensin II conditions the slow component of autoregulation of renal blood flow.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Enalaprilat; Homeostasis; Imidazoles; Kidney; Kinetics; Losartan; Male; Perfusion; Pressure; Rats; Rats, Sprague-Dawley; Tetrazoles; Vascular Resistance; Vasoconstriction; Vasodilation | 1993 |
Role of nitric oxide and angiotensin II in the regulation of sympathetic nerve activity in spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Biphenyl Compounds; Blood Pressure; Dipeptides; Heart Rate; Imidazoles; Lisinopril; Losartan; Male; Nitric Oxide; Oligopeptides; omega-N-Methylarginine; Pressoreceptors; Rats; Rats, Inbred SHR; Reflex; Tetrazoles | 1993 |
EXP3174, a metabolite of losartan (MK 954, DuP 753) is more potent than losartan in blocking the angiotensin II-induced responses in vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Cells, Cultured; Female; Imidazoles; In Vitro Techniques; Losartan; Muscle, Smooth, Vascular; Rats; Rats, Inbred WKY; RNA, Messenger; Tetrazoles | 1993 |
Agonistic and antagonistic properties of angiotensin analogs at the AT2 receptor in PC12W cells.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Biphenyl Compounds; Cyclic GMP; Imidazoles; Losartan; Oligopeptides; PC12 Cells; Pyridines; Rats; Receptors, Angiotensin; Tetrazoles | 1993 |
Anti-angiotensin antibodies cross-reactive with nonpeptide angiotensin antagonists as angiotensin receptor model.
Topics: Adrenocorticotropic Hormone; Amino Acid Sequence; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antibodies; Biphenyl Compounds; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Imidazoles; Losartan; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Naloxone; Pyridines; Saralasin; Structure-Activity Relationship; Tetrazoles | 1993 |
Converting enzyme inhibition modulates sympathetic neurotransmission in vivo via multiple mechanisms.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Biphenyl Compounds; Blood Pressure; Bradykinin; Diclofenac; Dogs; Epinephrine; Female; Imidazoles; Losartan; Muscle Denervation; Muscles; Norepinephrine; Phenoxybenzamine; Sympathetic Nervous System; Synaptic Transmission; Tetrazoles | 1993 |
Endogenous angiotensin II modulates the effect of atrial natriuretic peptide on extracellular fluid partition.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Biphenyl Compounds; Blood Pressure; Captopril; Enalaprilat; Extracellular Space; Hematocrit; Imidazoles; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin-Angiotensin System; Tetrazoles | 1993 |
Angiotensin II stimulates growth and steroidogenesis in zona fasciculata/reticularis cells from bovine adrenal cortex via the AT1 receptor subtype.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Cattle; Cell Division; Cells, Cultured; Hydrocortisone; Imidazoles; Losartan; Phosphoric Diester Hydrolases; Saralasin; Tetrazoles; Zona Fasciculata; Zona Reticularis | 1993 |
Pharmacological characteristics of the positive inotropic effect of angiotensin II in the rabbit ventricular myocardium.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Bupranolol; Heart Ventricles; Imidazoles; In Vitro Techniques; Losartan; Male; Myocardial Contraction; Myocardium; Papillary Muscles; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Prazosin; Pyridines; Rabbits; Saralasin; Tetrazoles | 1993 |
Identification and characterization of angiotensin II receptors in rat epididymal adipocyte membranes.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Adipose Tissue; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Biphenyl Compounds; Cell Membrane; Epididymis; Imidazoles; Losartan; Male; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Saralasin; Temperature; Tetrazoles | 1993 |
Angiotensin II responsiveness of rat paraventricular and subfornical organ neurons in vitro.
Topics: Action Potentials; Angiotensin II; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Imidazoles; Losartan; Male; Neurons; Paraventricular Hypothalamic Nucleus; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin-Angiotensin System; Signal Transduction; Subfornical Organ; Synaptic Transmission; Tetrazoles | 1993 |
In vivo pharmacology of SC-51316, a nonpeptidic angiotensin II receptor antagonist.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Enalapril; Hypertension; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Tetrazoles; Triazoles | 1993 |
Angiotensin II receptor subtypes on adrenal adenoma in primary hyperaldosteronism.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Autoradiography; Binding, Competitive; Biphenyl Compounds; Humans; Hyperaldosteronism; Imidazoles; Losartan; Male; Middle Aged; Pyridines; Receptors, Angiotensin; Tetrazoles | 1993 |
Haemodynamic and hormonal responses to losartan (DuP753/MK954) infusion during cardiac catheterization in conscious salt-deplete dogs.
Topics: Aldosterone; Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Cardiac Catheterization; Dogs; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Imidazoles; Losartan; Male; Stimulation, Chemical; Tetrazoles | 1993 |
The type 1 angiotensin-II receptor mediates intracellular calcium mobilization in rat luteal cells.
Topics: Adenosine Triphosphatases; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biological Transport; Biphenyl Compounds; Calcium; Corpus Luteum; Culture Media; Dinoprost; Endoplasmic Reticulum; Female; Imidazoles; Intracellular Membranes; Losartan; Osmolar Concentration; Pyridines; Rats; Receptors, Angiotensin; Terpenes; Tetrazoles; Thapsigargin | 1993 |
In vitro pharmacology of a novel non-peptide angiotensin II-receptor antagonist, E4177.
Topics: Adrenal Cortex; Adrenal Glands; Adrenal Medulla; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding Sites; Biphenyl Compounds; Humans; Imidazoles; In Vitro Techniques; Liver; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Peptidyl-Dipeptidase A; Pyridines; Rabbits; Rats; Rats, Wistar; Tetrazoles | 1993 |
Functional evidence that the angiotensin antagonist losartan crosses the blood-brain barrier in the rat.
Topics: Afferent Pathways; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Blood-Brain Barrier; Electric Stimulation; Imidazoles; Losartan; Male; Neurons; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Subfornical Organ; Tetrazoles | 1993 |
Angiotensin II receptors in rabbit vascular grafts.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Carotid Arteries; Imidazoles; Jugular Veins; Losartan; Male; Muscle, Smooth, Vascular; Rabbits; Receptors, Angiotensin; Tetrazoles | 1993 |
Hormonal and cardiovascular effects of losartan (DuP753), an angiotensin receptor antagonist, in nonhuman primates.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Feedback; Heart Rate; Hormones; Imidazoles; Losartan; Macaca fascicularis; Male; Renin; Sodium; Tetrazoles | 1993 |
Renal effects of acute endothelial-derived relaxing factor blockade are not mediated by angiotensin II.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Biphenyl Compounds; Blood Pressure; Diuresis; Glomerular Filtration Rate; Imidazoles; Kidney; Losartan; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Circulation; Tetrazoles; Time Factors | 1993 |
Microbial hydroxylation and glucuronidation of the angiotensin II (AII) receptor antagonist MK 954.
Topics: Actinomycetales; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biotransformation; Biphenyl Compounds; Chromatography, High Pressure Liquid; Glucuronates; Humans; Hydroxylation; Imidazoles; Liver; Losartan; Macaca; Magnetic Resonance Spectroscopy; Rats; Receptors, Angiotensin; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Ultraviolet; Streptococcus; Tetrazoles | 1993 |
Nonpeptide angiotensin AT1 and AT2 receptor ligands modulate the upper limit of cerebral blood flow autoregulation in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cerebrovascular Circulation; Homeostasis; Hypertension; Imidazoles; Laser-Doppler Flowmetry; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1993 |
Distinct signal transduction pathways for angiotensin-II in guinea pig gastric smooth muscle: differential blockade by indomethacin and tyrosine kinase inhibitors.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Calcium; Catechols; Cyclohexanones; Dose-Response Relationship, Drug; Epidermal Growth Factor; Genistein; Guinea Pigs; Imidazoles; In Vitro Techniques; Indoles; Indomethacin; Isoflavones; Losartan; Male; Muscle, Smooth; Nitriles; Protein-Tyrosine Kinases; Pyridines; Quinacrine; Signal Transduction; Stomach; Tetrazoles; Tyrphostins | 1993 |
Identification and characterisation of angiotensin II receptor subtypes in human brain.
Topics: Aged; Angiotensin II; Angiotensin Receptor Antagonists; Autoradiography; Binding, Competitive; Biphenyl Compounds; Brain Chemistry; Female; Humans; Imidazoles; In Vitro Techniques; Iodine Radioisotopes; Losartan; Male; Middle Aged; Pyridines; Radioligand Assay; Receptors, Angiotensin; Saralasin; Tetrazoles | 1993 |
The renin-angiotensin system and volume overload-induced cardiac hypertrophy in rats. Effects of angiotensin converting enzyme inhibitor versus angiotensin II receptor blocker.
Topics: Angiotensin II; Animals; Aorta; Arteriovenous Shunt, Surgical; Biphenyl Compounds; Body Weight; Cardiac Volume; Cardiomegaly; Enalapril; Hemodynamics; Imidazoles; Losartan; Male; Myocardium; Organ Size; Rats; Rats, Wistar; Renin; Renin-Angiotensin System; Tetrazoles; Venae Cavae | 1993 |
Analysis of the inhibitory effects of DuP 753 and EXP 3174 on responses to angiotensin II in the feline hindquarters vascular bed.
Topics: Angiotensin II; Angiotensin III; Animals; Biphenyl Compounds; Blood Pressure; Cats; Dose-Response Relationship, Drug; Female; Imidazoles; Losartan; Male; Perfusion; Tetrazoles | 1993 |
Effect of nonpeptide angiotensin AT-1 and AT-2 antagonists on isoproterenol-induced renin release.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Imidazoles; Injections, Intraventricular; Isoproterenol; Losartan; Male; Potassium; Pyridines; Rats; Rats, Sprague-Dawley; Renin; Tetrazoles | 1993 |
Functional role of brain AT1 and AT2 receptors in the central angiotensin II pressor response.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Brain; Chlorisondamine; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Injections, Intraventricular; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renal Circulation; Tetrazoles | 1993 |
Effect of Losartan, a nonpeptide angiotensin II receptor antagonist, on drinking behavior and renal actions of centrally administered renin.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cerebral Ventricles; Diuresis; Drinking Behavior; Imidazoles; Injections, Intraventricular; Injections, Subcutaneous; Kidney; Losartan; Male; Natriuresis; Rats; Rats, Sprague-Dawley; Renin; Tetrazoles; Time Factors | 1993 |
Regulation of vascular angiotensin release.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Animals; Aorta; Base Sequence; Biphenyl Compounds; Dexamethasone; Ethinyl Estradiol; Hindlimb; Imidazoles; Losartan; Male; Molecular Sequence Data; Muscle, Smooth, Vascular; Muscles; Nephrectomy; Oligodeoxyribonucleotides; Perfusion; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Renin; RNA, Messenger; Tetrazoles; Triiodothyronine | 1993 |
Increased angiotensin II type-1 receptor gene expression in neuronal cultures from spontaneously hypertensive rats.
Topics: Amino Acid Sequence; Angiotensin II; Animals; Biphenyl Compounds; Cells, Cultured; Gene Expression; Hydrolysis; Imidazoles; Inositol; Losartan; Molecular Sequence Data; Neurons; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; RNA, Messenger; Tetrazoles | 1993 |
Acute and chronic effects of losartan (DuP 753) on blood pressure and vascular reactivity in normotensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Electric Stimulation; Imidazoles; Losartan; Male; Rats; Rats, Sprague-Dawley; Tetrazoles; Vasoconstriction | 1993 |
Binding and signal transduction of the cloned vascular angiotensin II (AT1a) receptor cDNA stably expressed in Chinese hamster ovary cells.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Adenylyl Cyclases; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding Sites; Biphenyl Compounds; Calcium; CHO Cells; Cloning, Molecular; Cricetinae; DNA; Imidazoles; Losartan; Pyridines; Radioligand Assay; Receptors, Angiotensin; Signal Transduction; Tetrazoles; Transfection | 1993 |
Signal transduction mediated by angiotensin II receptor subtypes expressed in rat renal mesangial cells.
Topics: Adenylyl Cyclase Inhibitors; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Calcium; Cell Division; Cells, Cultured; Glomerular Mesangium; Imidazoles; Losartan; Oligopeptides; Protein Biosynthesis; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Signal Transduction; Tetrazoles | 1993 |
[125I]CGP 42112 binding reveals differences between rat brain and adrenal AT2 receptor binding sites.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Adrenal Glands; Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Biphenyl Compounds; Brain; Chromatography, High Pressure Liquid; Imidazoles; Losartan; Male; Mercaptoethanol; Oligopeptides; Oxidation-Reduction; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1993 |
Regulated expression of angiotensin II (AT2) binding sites in R3T3 cells.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; 3T3 Cells; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Bombesin; Cell Division; Fibroblast Growth Factor 2; Imidazoles; Losartan; Mice; Mitogens; Pyridines; Receptors, Angiotensin; Saralasin; Tetrazoles; Up-Regulation | 1993 |
Identification and characterization of a novel angiotensin binding site in cultured vascular smooth muscle cells that is specific for the hexapeptide (3-8) fragment of angiotensin II, angiotensin IV.
Topics: Amino Acid Sequence; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Aorta; Binding, Competitive; Biphenyl Compounds; Cattle; Cells, Cultured; Guanosine 5'-O-(3-Thiotriphosphate); Imidazoles; Losartan; Molecular Sequence Data; Muscle, Smooth, Vascular; Pyridines; Radioligand Assay; Receptors, Angiotensin; Tetrazoles | 1993 |
Angiotensin II binding sites on micro-organisms contaminating cell cultures.
Topics: Acholeplasma laidlawii; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cells, Cultured; Diterpenes; Drug Therapy, Combination; Glomerular Mesangium; Imidazoles; Losartan; Minocycline; Muscle, Smooth, Vascular; Rats; Receptors, Angiotensin; Tetrazoles | 1993 |
Role of AT1 receptors in the resetting of the baroreflex control of heart rate by angiotensin II in the rabbit.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Heart; Heart Rate; Imidazoles; Losartan; Male; Pressoreceptors; Pyridines; Rabbits; Receptors, Angiotensin; Tetrazoles | 1993 |
Angiotensin AT1 receptors mediate a positive inotropic effect of angiotensin II in guinea pig atria.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Biphenyl Compounds; Guinea Pigs; Heart; Heart Atria; Imidazoles; In Vitro Techniques; Losartan; Myocardial Contraction; Pyridines; Radiography; Receptors, Angiotensin; Tetrazoles | 1993 |
Characterization and regulation of the angiotensin II type-1 receptor (binding and mRNA) in human adrenal fasciculata-reticularis cells.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Biphenyl Compounds; Cell Line; Cells, Cultured; Cloning, Molecular; Gene Expression Regulation; Homeostasis; Humans; Imidazoles; Kinetics; Losartan; Oligodeoxyribonucleotides; Oligopeptides; Receptors, Angiotensin; RNA, Messenger; Tetrazoles; Transfection; Zona Fasciculata; Zona Reticularis | 1993 |
Reduction of myocardial infarct size by ramiprilat is independent of angiotensin II synthesis inhibition.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Electrophysiology; Female; Hemodynamics; Imidazoles; Losartan; Male; Myocardial Infarction; Myocardial Ischemia; Rabbits; Ramipril; Tetrazoles | 1993 |
Effect of chronic treatment with losartan potassium (DuP 753) on the elevation of blood pressure during chronic exposure of rats to cold.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Catecholamines; Cold Temperature; Eating; Hypertension; Imidazoles; Losartan; Male; Organ Size; Rats; Rats, Sprague-Dawley; Tetrazoles | 1993 |
Pharmacological characterization of the contractile responses to angiotensin analogues in guinea-pig isolated longitudinal muscle of small intestine.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atropine; Biphenyl Compounds; Guinea Pigs; Hypnotics and Sedatives; Imidazoles; In Vitro Techniques; Intestine, Small; Losartan; Male; Muscle Contraction; Muscle, Smooth; Pyridines; Tetrazoles; Tetrodotoxin | 1993 |
Functional roles of brain AT1 and AT2 receptors in the central angiotensin II pressor response in conscious young spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Brain; Disease Models, Animal; Heart Rate; Hypertension; Imidazoles; Injections, Intraventricular; Losartan; Male; Pyridines; Rats; Rats, Inbred SHR; Receptors, Angiotensin; Sympathetic Nervous System; Tetrazoles; Vasopressins | 1993 |
Characterization of angiotensin receptors mediating the neuromodulatory effects of angiotensin in the vas deferens of the rabbit.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Drug Interactions; Electric Stimulation; Imidazoles; Losartan; Male; Muscle Contraction; Pyridines; Rabbits; Receptors, Angiotensin; Tetrazoles; Vas Deferens | 1993 |
Upregulation of renin-angiotensin system and downregulation of kallikrein in obstructive nephropathy.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Gene Expression; Imidazoles; Kallikreins; Kidney; Kidney Diseases; Losartan; Male; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; RNA, Messenger; Tetrazoles; Ureteral Obstruction | 1993 |
Angiotensin type 2 receptors mediate depressor phase of biphasic pressure response to angiotensin.
Topics: Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Saralasin; Tetrazoles | 1993 |
Sodium and angiotensin in hypertension induced by long-term nitric oxide blockade.
Topics: Angiotensin II; Animals; Arginine; Biphenyl Compounds; Diet, Sodium-Restricted; Electrolytes; Hemodynamics; Hypertension; Imidazoles; Losartan; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organ Size; Rats; Rats, Wistar; Renin-Angiotensin System; Tetrazoles; Time Factors | 1993 |
Chimeric renin-angiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes.
Topics: Angiotensin I; Angiotensin II; Angiotensinogen; Animals; Biphenyl Compounds; Blood Pressure; Captopril; Dipeptides; Humans; Imidazoles; Losartan; Male; Mice; Mice, Transgenic; Morpholines; Recombinant Proteins; Renin; Renin-Angiotensin System; Tetrazoles | 1993 |
Increases in cytosolic Ca2+ in rat area postrema/mNTS neurons produced by angiotensin II and arginine-vasopressin.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Biphenyl Compounds; Calcium; Carbocyanines; Cells, Cultured; Cytosol; Fura-2; Image Processing, Computer-Assisted; Imidazoles; Immunohistochemistry; Losartan; Medulla Oblongata; Nerve Endings; Neuropeptides; Rats; Rats, Sprague-Dawley; Tetrazoles | 1993 |
Erythropoietin-induced antinatriuresis mediated by angiotensin II in perfused kidneys.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Captopril; Dose-Response Relationship, Drug; Erythropoietin; Imidazoles; In Vitro Techniques; Kidney; Losartan; Male; Natriuresis; Perfusion; Rats; Rats, Wistar; Tetrazoles | 1993 |
Losartan prevents salt-induced hypertension in reduced renal mass rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Heart Rate; Hypertension, Renal; Imidazoles; Kidney; Losartan; Male; Nephrectomy; Rats; Rats, Sprague-Dawley; Sodium Chloride; Tetrazoles | 1993 |
Intrinsic properties of the nonpeptide angiotensin II antagonist losartan in glomeruli and mesangial cells at high concentrations.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Calcium; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Glomerular Mesangium; Humans; Imidazoles; Kidney Glomerulus; Losartan; Male; Rats; Rats, Sprague-Dawley; Tetrazoles; Vasoconstrictor Agents | 1993 |
Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazoles.
Topics: Adrenal Cortex; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cattle; Dogs; Imidazoles; Losartan; Male; Models, Molecular; Molecular Structure; Muscle Contraction; Rabbits; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Structure-Activity Relationship; Tetrazoles; X-Ray Diffraction | 1993 |
Evidence that [Sar1]angiotensin II behaves differently from angiotensin II at angiotensin AT1 receptors in rabbit aorta.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Binding Sites; Biphenyl Compounds; Drug Interactions; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Pyridines; Rabbits; Receptors, Angiotensin; Tetrazoles | 1993 |
Impaired retention by angiotensin II mediated by the AT1 receptor.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Avoidance Learning; Biphenyl Compounds; Dentate Gyrus; Electroshock; Imidazoles; Long-Term Potentiation; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1995 |
Angiotensin-II-induced cell hypertrophy: potential role of impaired proteolytic activity in cultured LLC-PK1 cells.
Topics: Analysis of Variance; Angiotensin II; Animals; Biphenyl Compounds; Calcium; Calcium Channel Blockers; Cell Count; Cells, Cultured; Cycloheximide; DNA; Hypertrophy; Imidazoles; Kidney; LLC-PK1 Cells; Losartan; Oligopeptides; Protein Synthesis Inhibitors; Proteins; Swine; Tetrazoles; Verapamil | 1995 |
Nitric oxide antagonizes the actions of angiotensin II to enhance tubuloglomerular feedback responsiveness.
Topics: Angiotensin II; Animals; Arginine; Biphenyl Compounds; Capillaries; Feedback; Imidazoles; Injections; Injections, Intravenous; Kidney Glomerulus; Kidney Tubules; Losartan; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Sprague-Dawley; Tetrazoles | 1995 |
Mechanisms of angiotensin II chronotropic effect in anaesthetized dogs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alkaloids; Anesthesia; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Dogs; Female; Heart Rate; Imidazoles; Injections; Losartan; Male; Nifedipine; Receptors, Adrenergic, alpha; Sinoatrial Node; Staurosporine; Tetrazoles; Vagotomy; Vasoconstrictor Agents; Vasodilator Agents | 1995 |
In vivo pharmacological characterization of UP 269-6, a novel nonpeptide angiotensin II receptor antagonist.
Topics: Administration, Oral; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Decerebrate State; Dogs; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Injections, Intravenous; Losartan; Male; Pyrimidines; Rats; Rats, Sprague-Dawley; Species Specificity; Tetrazoles; Vasoconstrictor Agents | 1995 |
Role of angiotensin II in dietary modulation of rat late distal tubule bicarbonate flux in vivo.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Bicarbonates; Biphenyl Compounds; Diet; Enalaprilat; Fasting; Imidazoles; Kidney Tubules, Distal; Losartan; Male; Perfusion; Rats; Rats, Sprague-Dawley; Renin; Sodium Chloride; Tetrazoles | 1996 |
Augmentation of coronary blood flow by ACE inhibition: role of angiotensin and bradykinin.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Flow Velocity; Blood Pressure; Bradykinin; Captopril; Coronary Vessels; Imidazoles; Losartan; Perfusion; Swine; Tetrazoles | 1995 |
Interaction of nonpeptide angiotensin II receptor antagonists with the urate transporter in rat renal brush-border membranes.
Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biological Transport; Biphenyl Compounds; Carbon Radioisotopes; Hydrogen-Ion Concentration; Imidazoles; Kidney; Kinetics; Losartan; Male; Microvilli; Naphthalenes; Rats; Rats, Sprague-Dawley; Tetrazoles; Thiophenes; Uric Acid | 1996 |
Effects of the specific angiotensin II receptor antagonist losartan on urate homeostasis and intestinal urate transport.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biological Transport; Biphenyl Compounds; Chlorides; Colon; Homeostasis; Imidazoles; Intestinal Absorption; Kidney; Kidney Failure, Chronic; Losartan; Male; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Tetrazoles; Urate Oxidase; Uric Acid; Xanthine Oxidase | 1996 |
Lack of involvement of bradykinin in the vascular sympathoinhibitory effects of angiotensin converting enzyme inhibitors in spontaneously hypertensive rats.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Bradykinin; Bradykinin Receptor Antagonists; Decerebrate State; Hemodynamics; Hypertension; Imidazoles; Indoles; Losartan; Male; Muscle, Smooth, Vascular; Perindopril; Rats; Rats, Inbred SHR; Sympathetic Nervous System; Synaptic Transmission; Tetrazoles; Vasoconstriction | 1995 |
Haemodynamic effects of losartan and the endothelin antagonist, SB 209670, in conscious, transgenic ((mRen-2)27), hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Genetically Modified; Antihypertensive Agents; Biphenyl Compounds; Endothelin Receptor Antagonists; Endothelins; Hemodynamics; Hypertension; Imidazoles; Indans; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Regional Blood Flow; Tetrazoles | 1995 |
Angiotensin II-induced responses in vascular smooth muscle cells: inhibition by non-peptide receptor antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Biphenyl Compounds; Cells, Cultured; Dinoprostone; DNA; Epoprostenol; Imidazoles; Inositol 1,4,5-Trisphosphate; Leucine; Losartan; Male; Muscle, Smooth, Vascular; Protein Biosynthesis; Pyridines; Pyrimidinones; Rats; Rats, Sprague-Dawley; Tetrazoles; Thiophenes; Thymidine | 1995 |
Angiotensin II receptors are exclusively of the AT1 subtype in cultured human vascular smooth muscle cells.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Binding, Competitive; Biphenyl Compounds; Cells, Cultured; Humans; Imidazoles; Kinetics; Losartan; Muscle, Smooth, Vascular; Oligopeptides; Receptors, Angiotensin; Saralasin; Tetrazoles | 1995 |
Role of angiotensin II in the expression and regulation of transforming growth factor-beta in obstructive nephropathy.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Gene Expression; Imidazoles; Immunohistochemistry; Kidney; Kidney Diseases; Losartan; Male; Rats; Rats, Wistar; RNA, Messenger; Tetrazoles; Tissue Distribution; Transforming Growth Factor beta; Ureteral Obstruction | 1995 |
[Hormonal contribution to short-term variability of blood pressure in a renovascular hypertension model].
Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Bradykinin; Disease Models, Animal; Heart Rate; Hypertension, Renovascular; Imidazoles; Kallikrein-Kinin System; Losartan; Male; Rats; Receptors, Angiotensin; Renin-Angiotensin System; Signal Processing, Computer-Assisted; Tetrazoles | 1995 |
Polar residues in the transmembrane domains of the type 1 angiotensin II receptor are required for binding and coupling. Reconstitution of the binding site by co-expression of two deficient mutants.
Topics: Amino Acid Sequence; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Asparagine; Base Sequence; Binding Sites; Biphenyl Compounds; Cell Line; Chlorocebus aethiops; CHO Cells; Cricetinae; DNA Primers; Imidazoles; Inositol Phosphates; Kinetics; Losartan; Molecular Sequence Data; Mutagenesis; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Oligopeptides; Point Mutation; Polymerase Chain Reaction; Rats; Receptors, Angiotensin; Recombinant Proteins; Sequence Deletion; Serine; Tetrazoles; Transfection | 1996 |
Binding of valsartan to mammalian angiotensin AT1 receptors.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Adrenal Glands; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Binding Sites; Binding, Competitive; Biphenyl Compounds; Callithrix; Cell Membrane; Dogs; Humans; Imidazoles; Liver; Losartan; Molecular Structure; Muscle, Smooth, Vascular; Protein Binding; Rats; Receptors, Angiotensin; Tetrazoles; Valine; Valsartan | 1995 |
Losartan: the first angiotensin receptor antagonist in clinical use.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Tetrazoles | 1995 |
Effects of losartan on insulin sensitivity in severe hypertension: connections through sympathetic nervous system activity?
Topics: Adult; Analysis of Variance; Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Blood Glucose; Blood Viscosity; Glucose Clamp Technique; Humans; Hypertension; Imidazoles; Insulin Resistance; Losartan; Male; Sympathetic Nervous System; Tetrazoles | 1995 |
Furosemide elicits immediate sympathoexcitation via a renal mechanism independent of angiotensin II.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Diuretics; Ethanolamine; Ethanolamines; Furosemide; Heart Rate; Imidazoles; Injections, Intravenous; Injections, Intraventricular; Losartan; Male; Neurons, Efferent; Rats; Rats, Sprague-Dawley; Renin; Sympathetic Nervous System; Tetrazoles | 1995 |
Characterization of contractile response to angiotensin in epididymal rat vas deferens.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Dose-Response Relationship, Drug; Electric Stimulation; Epididymis; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle Contraction; Muscle, Smooth; Oligopeptides; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Tetrazoles; Vas Deferens; Vasoconstrictor Agents | 1995 |
Unilateral ureteral obstruction increases glomerular soluble guanylyl cyclase activity.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Cyclic GMP; Imidazoles; Kidney Glomerulus; Losartan; Male; Nitroprusside; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley; Tetrazoles; Ureteral Obstruction; Vasoconstrictor Agents | 1995 |
Intrastriatal angiotensin II induces turning behaviour in 6-hydroxydopamine lesioned rats.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Corpus Striatum; Dopamine; Functional Laterality; Haloperidol; Imidazoles; Losartan; Male; Motor Activity; Oxidopamine; Rats; Rats, Sprague-Dawley; Rotation; Substantia Nigra; Tetrazoles | 1995 |
A computer modeling postulated mechanism for angiotensin II receptor activation.
Topics: Amino Acid Sequence; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding Sites; Biphenyl Compounds; Computer Simulation; Humans; Imidazoles; Losartan; Mice; Models, Molecular; Molecular Sequence Data; Protein Conformation; Rats; Receptors, Angiotensin; Sequence Homology, Amino Acid; Tetrazoles | 1995 |
Nitric oxide and the depressor response to angiotensin blockade in hypertension.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aortic Coarctation; Arginine; Biphenyl Compounds; Blood Pressure; Hypertension; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ramipril; Rats; Rats, Sprague-Dawley; Renin; Tetrazoles; Vasoconstrictor Agents | 1996 |
Interactive control of renal function by alpha 2-adrenergic system and nitric oxide: role of angiotensin II.
Topics: Angiotensin II; Animals; Arginine; Biphenyl Compounds; Hemodynamics; Imidazoles; Kidney; Losartan; Male; Nitric Oxide; omega-N-Methylarginine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Tetrazoles | 1995 |
New angiotensin-II blocker.
Topics: Aged; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Diuretics; Drug Interactions; Drug Therapy, Combination; Humans; Hypertension; Imidazoles; Losartan; Male; Tetrazoles | 1996 |
Hypotensive response to losartan in normal rats. Role of Ang II and the area postrema.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Cerebral Ventricles; Hypotension; Imidazoles; Losartan; Male; Rats; Rats, Sprague-Dawley; Tetrazoles | 1996 |
Vascular smooth muscle polyploidy and cardiac hypertrophy in genetic hypertension.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Cardiomegaly; Female; Hypertension; Imidazoles; Indoles; Losartan; Male; Muscle, Smooth, Vascular; Perindopril; Polyploidy; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazoles | 1996 |
Effects of angiotensin II antagonists on the contractile and hydrosmotic effect of AT II and AT III in the toad (Bufo arenarum).
Topics: Analysis of Variance; Angiotensin II; Angiotensin III; Animals; Antihypertensive Agents; Aorta; Biphenyl Compounds; Bufo arenarum; Dose-Response Relationship, Drug; Drug Interactions; Female; Imidazoles; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Oligopeptides; Osmolar Concentration; Osmosis; Pyridines; Skin; Tetrazoles; Vasoconstrictor Agents | 1996 |
Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.
Topics: Acetylcholine; Angiotensin II; Animals; Antihypertensive Agents; Aorta; Arginine; Biphenyl Compounds; Calcimycin; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Hypertension; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; NADH, NADPH Oxidoreductases; Nitric Oxide Synthase; Nitroglycerin; Norepinephrine; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Superoxides; Tetrazoles | 1996 |
The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3', 5'-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats.
Topics: Analysis of Variance; Angiotensin II; Animals; Biphenyl Compounds; Cyclic AMP; Dinoprostone; Extracellular Space; Female; Imidazoles; Kidney; Kinetics; Losartan; Microdialysis; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Reference Values; Sodium, Dietary; Tetrazoles; Time Factors | 1996 |
Cellular mechanism of angiotensin II-induced atrial natriuretic peptide release in rat right atrial tissue.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Animals; Atrial Natriuretic Factor; Biphenyl Compounds; Calcium; Chromatography, Ion Exchange; Heart Atria; Imidazoles; In Vitro Techniques; Losartan; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetrazoles | 1996 |
The role of angiotensin AT1 receptors in the diuretic, natriuretic, kaliuretic and blood pressure responses induced by angiotensin II activation of the median preoptic nucleus in conscious rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Diuresis; Imidazoles; Losartan; Male; Natriuresis; Potassium; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1995 |
Effects of losartan on contractile responses of conductance and resistance arteries from rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Biphenyl Compounds; Dinoprost; Imidazoles; In Vitro Techniques; Losartan; Male; Mesenteric Arteries; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Wistar; Tetrazoles; Thromboxane A2; Vasoconstriction | 1995 |
Neuroendocrine and cardiovascular effects of serotonin: selective role of brain angiotensin on vasopressin.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Arginine Vasopressin; Biphenyl Compounds; Blood Pressure; Cerebral Ventricles; Corticosterone; Enalapril; Ergolines; Fenfluramine; Heart Rate; Imidazoles; Injections, Intraventricular; Losartan; Male; Oxytocin; Prolactin; Rats; Rats, Sprague-Dawley; Renin; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Tetrazoles | 1996 |
Cyclic adenosine 3',5'-monophosphate-independent regulation of cytosolic calcium in Sertoli cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atrial Natriuretic Factor; Biphenyl Compounds; Calcium; Calcium Channel Blockers; Cyclic AMP; Cytosol; Dinoprost; Enzyme Inhibitors; Imidazoles; Isoquinolines; Kinetics; Losartan; Male; Protein Kinase C; Pyridines; Rats; Rats, Wistar; Sertoli Cells; Sulfonamides; Terpenes; Tetrazoles; Thapsigargin; Vasopressins | 1996 |
Renin-angiotensin system and cell communication in the failing heart.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Cells, Cultured; Cricetinae; Enalapril; Gap Junctions; Heart Conduction System; Heart Failure; Imidazoles; Losartan; Male; Membrane Potentials; Mesocricetus; Patch-Clamp Techniques; Renin-Angiotensin System; Tetrazoles | 1996 |
Changes in the baroreflex control of heart rate produced by central infusion of selective angiotensin antagonists in hypertensive rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Baroreflex; Biphenyl Compounds; Heart Rate; Imidazoles; Losartan; Male; Oligopeptides; Peptide Fragments; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazoles | 1996 |
Angiotensin II causes weight loss and decreases circulating insulin-like growth factor I in rats through a pressor-independent mechanism.
Topics: Analysis of Variance; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Body Weight; Hematocrit; Hydralazine; Hypertension; Imidazoles; Infusions, Intravenous; Insulin-Like Growth Factor Binding Protein 2; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor Binding Protein 4; Insulin-Like Growth Factor I; Losartan; Male; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Reference Values; Tetrazoles; Time Factors; Vasodilator Agents; Weight Loss | 1996 |
Angiotensin II induces TIMP-1 production in rat heart endothelial cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Cells, Cultured; Culture Media, Conditioned; Endothelium; Enzyme Inhibitors; Glycoproteins; Imidazoles; Losartan; Myocardium; Protease Inhibitors; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Rats; RNA, Messenger; Tetrazoles; Tissue Inhibitor of Metalloproteinases; Up-Regulation; Vasoconstrictor Agents | 1996 |
Angiotensin II receptor subtypes and phosphoinositide hydrolysis in rat adrenal medulla.
Topics: Adrenal Medulla; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Biphenyl Compounds; Cyclic GMP; Hydrolysis; Imidazoles; Losartan; Male; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1995 |
Diphenylpropionic acids as new AT1 selective angiotensin II antagonists.
Topics: Administration, Oral; Adrenal Glands; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Biphenyl Compounds; Blood Pressure; Diet, Sodium-Restricted; Furosemide; Imidazoles; In Vitro Techniques; Indicators and Reagents; Kinetics; Liver; Losartan; Male; Models, Molecular; Molecular Structure; Muscle, Smooth, Vascular; Phenylpropionates; Rabbits; Rats; Stereoisomerism; Structure-Activity Relationship; Tetrazoles | 1996 |
Angiotensin II-induced progression of neointimal thickening in the balloon-injured rat carotid artery is AT1 receptor mediated.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Carotid Arteries; Carotid Artery Diseases; Catheterization; DNA; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles | 1996 |
Angiotensin II receptor subtypes in the adrenals of pregnant rats.
Topics: Adrenal Glands; Adrenal Medulla; Angiotensin II; Animals; Binding, Competitive; Biphenyl Compounds; Cell Membrane; Female; Humans; Imidazoles; In Vitro Techniques; Kinetics; Losartan; Pregnancy; Pregnancy, Animal; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; RNA, Messenger; Tetrazoles; Zona Glomerulosa | 1995 |
Angiotensin II receptors and angiotensin II stimulation of ciliary activity in human fallopian tube.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Cilia; Fallopian Tubes; Female; Humans; Imidazoles; Immunoenzyme Techniques; Losartan; Oligopeptides; Pregnancy; Premenopause; Receptors, Angiotensin; Tetrazoles; Tissue Distribution | 1996 |
Endogenous production of angiotensin II modulates rat proximal tubule transport.
Topics: Angiotensin II; Animals; Biological Transport; Biphenyl Compounds; Imidazoles; Kidney Tubules, Proximal; Losartan; Male; Rats; Rats, Sprague-Dawley; Tetrazoles | 1996 |
[Losartan. The first non-peptide angiotensin II receptor antagonist for treatment of hypertension].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Humans; Imidazoles; Losartan; Receptors, Angiotensin; Tetrazoles | 1996 |
Angiotensin receptors in myometrium and myometrial vessels from uteri of women during the follicular and luteal phases of the menstrual cycle and in late pregnancy.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Vessels; Cell Membrane; Female; Follicular Phase; Humans; Imidazoles; Losartan; Luteal Phase; Myometrium; Pregnancy; Pregnancy Trimester, Third; Pyridines; Receptors, Angiotensin; Tetrazoles | 1996 |
Localization and quantitation of angiotensin AT1 and AT2 receptors in the pregnant and non-pregnant sheep uterus.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Anestrus; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Autoradiography; Binding, Competitive; Biphenyl Compounds; Fallopian Tubes; Female; Imidazoles; Losartan; Muscle, Smooth; Ovary; Pregnancy; Pregnancy, Animal; Pyridines; Radioligand Assay; Receptors, Angiotensin; Sheep; Tetrazoles; Uterus | 1996 |
Effects of angiotensin II infusion and inhibition of nitric oxide synthase on the rat aorta.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta; Arginine; Biphenyl Compounds; Cell Division; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; Imidazoles; Infusion Pumps, Implantable; Losartan; Macrophages; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Tetrazoles | 1996 |
Angiotensin II increases left ventricular mass without affecting myosin isoform mRNAs.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Heart Ventricles; Hemodynamics; Hydralazine; Hypertrophy, Left Ventricular; Imidazoles; Infusion Pumps, Implantable; Losartan; Male; Myosin Heavy Chains; Organ Size; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Tetrazoles | 1996 |
Angiotensin II activates pressor and depressor sites of the pontomedulla that react to glutamate.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Bradycardia; Cats; Electroencephalography; Imidazoles; Losartan; Medulla Oblongata; Pons; Rats; Rhombencephalon; Tachycardia; Tetrazoles | 1996 |
A long-term receptor stimulation is requisite for angiotensin II-dependent DNA synthesis in vascular smooth muscle cells from spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Base Sequence; Benzimidazoles; Biphenyl Compounds; Calcium; Cells, Cultured; DNA Replication; Fibroblast Growth Factor 2; Imidazoles; In Vitro Techniques; Losartan; Molecular Sequence Data; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Pyridines; Rats; Rats, Inbred SHR; Receptors, Platelet-Derived Growth Factor; Tetrazoles | 1995 |
The angiotensin II subtype 2 (AT2) receptor is linked to protein kinase C but not cAMP-dependent pathways in the cardiomyocyte.
Topics: Adrenergic beta-Agonists; Angiotensin II; Animals; Biphenyl Compounds; Chick Embryo; Cyclic AMP; Enzyme Activation; Heart; Imidazoles; Isoproterenol; Losartan; Myocardium; Protein Kinase C; Pyridines; Receptors, Adrenergic, beta; Receptors, Angiotensin; Signal Transduction; Tetrazoles; Vasoconstrictor Agents | 1996 |
Control of hepatic carbohydrate metabolism and haemodynamics in perfused rat liver by arterial and portal angiotensin II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Glucose; Hepatic Artery; Imidazoles; Infusions, Intra-Arterial; Infusions, Intravenous; Lactates; Liver; Liver Circulation; Losartan; Male; Perfusion; Portal Vein; Rats; Rats, Inbred Lew; Regional Blood Flow; Tetrazoles; Vasoconstrictor Agents | 1996 |
Effect of a non-peptide angiotensin receptor antagonist on water intake caused by centrally administered carbachol in the rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Carbachol; Drinking; Imidazoles; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1996 |
Regional haemodynamic effects of antagonists of angiotensin II, endothelin and adrenoceptors in conscious, vasopressin-deficient, genetically hypertensive rats.
Topics: Adrenergic Antagonists; Angiotensin II; Animals; Biphenyl Compounds; Endothelins; Hemodynamics; Hypertension; Imidazoles; Indans; Losartan; Male; Rats; Sodium Chloride; Tetrazoles; Vasopressins | 1996 |
Ability of angiotensin II to modulate striatal dopamine release via the AT1 receptor in vitro and in vivo.
Topics: Angiotensin I; Angiotensin II; Animals; Biphenyl Compounds; Corpus Striatum; Dopamine; Extracellular Space; Female; Imidazoles; In Vitro Techniques; Losartan; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles | 1996 |
Inhibitory effect of DUP-753 on the drinking responses of rats to central administration of noradrenaline and angiotensin II and to dehydration.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Drinking Behavior; Imidazoles; Injections, Intraventricular; Losartan; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Tetrazoles; Water Deprivation | 1996 |
Angiotensin II regulation of intracellular calcium in astroglia cultured from rat hypothalamus and brainstem.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Astrocytes; Biphenyl Compounds; Brain Stem; Cadmium; Caffeine; Calcium; Calcium Channel Blockers; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gadolinium; Hypothalamus; Imidazoles; Indoles; Losartan; Nifedipine; Phosphodiesterase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Ryanodine; Terpenes; Tetrazoles; Thapsigargin; Time Factors | 1996 |
Chronic blockade of AT2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Biphenyl Compounds; Blood Pressure; Collagen; Elastin; Fibrosis; Hypertension; Hypertrophy; Imidazoles; Infusions, Parenteral; Losartan; Male; Muscle, Smooth, Vascular; Phenylephrine; Pyridines; Rats; Rats, Wistar; Reference Values; Tetrazoles | 1996 |
Angiotensin II type 2 receptor-mediated regulation of rat neuronal K+ channels.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cells, Cultured; Imidazoles; Kinetics; Losartan; Neurons; Oligopeptides; Patch-Clamp Techniques; Potassium Channels; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1996 |
Comparative effects of contraction and angiotensin II on growth of adult feline cardiocytes in primary culture.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cats; Cell Division; Cells, Cultured; Electric Stimulation; Imidazoles; Losartan; Myocardial Contraction; Myocardium; Receptors, Angiotensin; Tetrazoles | 1996 |
Regulation of ANG II receptor in hypertension: role of ANG II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Gene Expression; Hypertension; Imidazoles; Losartan; Male; Nephrectomy; Ramipril; Rats; Rats, Wistar; Receptors, Angiotensin; RNA, Messenger; Tetrazoles; Transforming Growth Factor beta | 1996 |
Acute and chronic angiotensin hypertension: neural and nonneural components, time course, and dose dependency.
Topics: Acute Disease; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Chlorisondamine; Chronic Disease; Dose-Response Relationship, Drug; Ganglionic Blockers; Hypertension; Imidazoles; Losartan; Male; Nervous System Physiological Phenomena; Rats; Rats, Sprague-Dawley; Tetrazoles | 1996 |
Losartan reduces cardiac mass and improves coronary flow reserve in the spontaneously hypertensive rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Coronary Circulation; Hemodynamics; Hypertension; Hypertrophy, Left Ventricular; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazoles | 1996 |
Role of angiotensin II and catecholamines in blood pressure variability responses to stress in SHR.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Catecholamines; Heart Rate; Imidazoles; Losartan; Male; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stress, Physiological; Tetrazoles | 1996 |
Role of protein kinase C in angiotensin II-induced renal vasoconstriction in genetically hypertensive rats.
Topics: Alkaloids; Angiotensin II; Animals; Antihypertensive Agents; Benzophenanthridines; Biphenyl Compounds; Hemodynamics; Hypertension; Imidazoles; Losartan; Phenanthridines; Protein Kinase C; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Renal Circulation; Staurosporine; Tetrazoles; Vasoconstrictor Agents | 1996 |
Sympathoexcitatory and pressor responses to increased brain sodium and ouabain are mediated via brain ANG II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Brain; Heart Rate; Imidazoles; Immunoglobulin Fab Fragments; Injections, Intraventricular; Kidney; Losartan; Male; Ouabain; Rats; Rats, Wistar; Saline Solution, Hypertonic; Sodium; Sympathetic Nervous System; Tetrazoles | 1996 |
Role of ANG II in hypertension produced by chronic inhibition of nitric oxide synthase in conscious rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Enalapril; Hypertension; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reference Values; Tetrazoles; Time Factors | 1996 |
Effect of endogenous angiotensin II on renal nerve activity and its arterial baroreflex regulation.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Arteries; Baroreflex; Biphenyl Compounds; Blood Pressure; Diet, Sodium-Restricted; Efferent Pathways; Imidazoles; Injections, Intravenous; Injections, Intraventricular; Kidney; Losartan; Male; Methoxamine; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Tetrazoles | 1996 |
Role of aldosterone in the remnant kidney model in the rat.
Topics: Adrenal Glands; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Body Weight; Disease Models, Animal; Enalapril; Imidazoles; Kidney; Kidney Diseases; Losartan; Male; Mineralocorticoid Receptor Antagonists; Nephrectomy; Organ Size; Rats; Rats, Sprague-Dawley; Spironolactone; Tetrazoles | 1996 |
The role of the renin-angiotensin system in cisplatin nephrotoxicity.
Topics: Angiotensin II; Animals; Antineoplastic Agents; Biphenyl Compounds; Blood Urea Nitrogen; Cisplatin; Creatinine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Imidazoles; Injections, Intraperitoneal; Kidney; Kidney Function Tests; Losartan; Male; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Tetrazoles | 1995 |
Endogenous angiotensin II inhibits natriuresis after acute volume expansion in the neonatal rat.
Topics: Angiotensin II; Animals; Animals, Newborn; Animals, Suckling; Biphenyl Compounds; Diuresis; Glomerular Filtration Rate; Hematocrit; Imidazoles; In Vitro Techniques; Losartan; Male; Natriuresis; Plasma Substitutes; Potassium; Rats; Rats, Sprague-Dawley; Sodium Chloride; Tetrazoles | 1996 |
The contribution of AT1 and AT2 angiotensin receptors to its cognitive effects.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Cognition; Imidazoles; Losartan; Oligopeptides; Rats; Receptors, Angiotensin; Tetrazoles | 1996 |
Effects of angiotensin II and angiotensin-converting enzyme inhibitors on human myocardium.
Topics: Adolescent; Adult; Aged; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Electric Stimulation; Female; Heart; Heart Atria; Heart Ventricles; Humans; Imidazoles; In Vitro Techniques; Isometric Contraction; Losartan; Male; Middle Aged; Myocardial Contraction; Papillary Muscles; Pyridines; Receptors, Angiotensin; Tetrazoles; Vasoconstrictor Agents | 1995 |
Differential contractile response of cultured microvascular pericytes to vasoactive agents.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Arterioles; Biphenyl Compounds; Eels; Histamine; Imidazoles; Losartan; Microcirculation; Microscopy, Phase-Contrast; Tetrazoles; Vasoconstriction; Vasoconstrictor Agents | 1994 |
Angiotensin II receptor expression in the conduction system and arterial duct of neonatal and adult rat hearts.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Atrioventricular Node; Autoradiography; Binding Sites; Biphenyl Compounds; Female; Imidazoles; Iodine Radioisotopes; Losartan; Male; Oligopeptides; Pregnancy; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1996 |
Angiotensin type 1 receptor antagonists CV-11974 and EXP 3174 cause selective renal vasodilatation in conscious spontaneously hypertensive rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Tetrazoles; Vasodilation | 1996 |
p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Vessels; Cytochrome b Group; DNA, Antisense; DNA, Complementary; Hydrogen Peroxide; Hypertrophy; Imidazoles; Losartan; Male; Membrane Transport Proteins; Muscle, Smooth, Vascular; NADH, NADPH Oxidoreductases; NADPH Dehydrogenase; NADPH Oxidases; Phosphoproteins; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxides; Tetrazoles; Transfection; Vasoconstrictor Agents | 1996 |
Angiotensin II blockade of long-term potentiation at the perforant path--granule cell synapse in vitro.
Topics: Analysis of Variance; Angiotensin II; Animals; Biphenyl Compounds; Electric Stimulation; Evoked Potentials; Hippocampus; Imidazoles; In Vitro Techniques; Long-Term Potentiation; Losartan; Male; Neurons; Rats; Rats, Sprague-Dawley; Synapses; Tetrazoles | 1996 |
Effect of acute and chronic losartan treatment on glucose tolerance and insulin sensitivity in fructose-fed rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Body Weight; Cardiomegaly; Diet; Fructose; Glucose Tolerance Test; Hyperinsulinism; Imidazoles; Insulin; Insulin Resistance; Losartan; Male; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Tetrazoles | 1996 |
Role of nitric oxide and angiotensin II in diabetes mellitus-induced glomerular hyperfiltration.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Imidazoles; Kidney; Losartan; Nephrectomy; Nitric Oxide; Nitroarginine; Rats; Rats, Sprague-Dawley; Tetrazoles | 1996 |
Losartan exerts antiarrhythmic activity independent of angiotensin II receptor blockade in simulated ventricular ischemia and reperfusion.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anti-Arrhythmia Agents; Biphenyl Compounds; Electric Stimulation; Endocardium; Guinea Pigs; Heart Conduction System; Imidazoles; In Vitro Techniques; Losartan; Male; Myocardial Ischemia; Reperfusion Injury; Tetrazoles | 1996 |
Renin-angiotensin system in stretch-induced hypertrophy of cultured neonatal rat heart cells.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Animals; Antihypertensive Agents; Biphenyl Compounds; Captopril; Cardiomegaly; Cells, Cultured; Heart; Imidazoles; Losartan; Muscle Proteins; Muscle Spindles; Myocardium; Rats; Rats, Sprague-Dawley; Renin; Tetrazoles | 1996 |
Potentiation of purinergic transmission by angiotensin in prostatic rat vas deferens.
Topics: Adrenergic Uptake Inhibitors; Angiotensin I; Angiotensin II; Animals; Biphenyl Compounds; Electric Stimulation; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle Contraction; Norepinephrine; Oligopeptides; Prostate; Protease Inhibitors; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Reserpine; Synaptic Transmission; Tetrazoles; Vas Deferens | 1996 |
Functional evidence for the ability of angiotensin AT1 receptor antagonists to cross the blood-brain barrier in rats.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Blood-Brain Barrier; Carbachol; Dose-Response Relationship, Drug; Drinking; Imidazoles; Injections, Intraperitoneal; Injections, Intraventricular; Losartan; Male; Nicotinic Acids; Pyrimidinones; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Tetrazoles; Thiophenes | 1996 |
Angiotensin II and glutamate influence area postrema neurons in rat brain slices.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Brain; Cerebrospinal Fluid; Electrophysiology; Excitatory Amino Acids; Glutamic Acid; Imidazoles; Losartan; Male; Medulla Oblongata; Neurons; Rats; Rats, Sprague-Dawley; Tetrazoles; Vasoconstrictor Agents | 1996 |
Angiotensin II-induced renal responses in anesthetized rabbits: effects of N omega-nitro-L-arginine methyl ester and losartan.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Enzyme Inhibitors; Hemodynamics; Imidazoles; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rabbits; Receptors, Angiotensin; Tetrazoles; Vasoconstrictor Agents | 1996 |
Receptor-mediated intrarenal angiotensin II augmentation in angiotensin II-infused rats.
Topics: Angiotensin II; Angiotensinogen; Animals; Biphenyl Compounds; Hypertension; Imidazoles; Kidney; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin; Tetrazoles | 1996 |
Angiotensin-converting enzyme activity in retinas of streptozotocin-induced and Zucker diabetic rats. The effect of angiotensin II on Na+,K(+)-ATPase activity.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Imidazoles; Isoenzymes; Lipoxygenase Inhibitors; Losartan; Male; Masoprocol; Peptidyl-Dipeptidase A; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Rats, Zucker; Retina; Sodium-Potassium-Exchanging ATPase; Tetrazoles; Vasoconstrictor Agents | 1996 |
Comparison between chronic converting enzyme inhibition and AT1 blockade in mRen2 transgenic rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Genetically Modified; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Hypertension; Imidazoles; Isoquinolines; Losartan; Male; Natriuresis; Quinapril; Rats; Tetrahydroisoquinolines; Tetrazoles | 1996 |
Contribution of the renin-angiotensin and kallikrein-kinin systems to short-term variability of blood pressure in two-kidney, one-clip hypertensive rats.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Heart Rate; Hypertension, Renovascular; Imidazoles; Kallikrein-Kinin System; Losartan; Male; Rats; Rats, Wistar; Renin; Renin-Angiotensin System; Tetrazoles | 1996 |
Pressor action of angiotensin I at the ventrolateral medulla: effect of selective angiotensin blockade.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Imidazoles; Losartan; Male; Medulla Oblongata; Microinjections; Peptide Fragments; Ramipril; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles | 1996 |
Effects of angiotensin II receptor blockade during exercise: comparison of losartan and saralasin.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Coronary Circulation; Heart Rate; Hemodynamics; Imidazoles; Losartan; Physical Exertion; Receptors, Angiotensin; Regional Blood Flow; Renal Circulation; Saralasin; Splanchnic Circulation; Swine; Swine, Miniature; Tetrazoles; Water-Electrolyte Balance | 1996 |
Angiotensin II as a stimulator of Na(+)-dependent Ca2+ efflux from freshly isolated adult rat cardiomyocytes.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Calcium; Calcium Radioisotopes; Dose-Response Relationship, Drug; Imidazoles; Losartan; Male; Muscle Fibers, Skeletal; Myocardium; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium; Tetrazoles | 1996 |
Blockade of the renin-angiotensin system in heart failure in conscious dogs.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Binding, Competitive; Biphenyl Compounds; Captopril; Dogs; Heart Failure; Hemodynamics; Imidazoles; Losartan; Male; Myocardium; Pyridines; Reference Values; Renin-Angiotensin System; Tetrazoles | 1995 |
Threshold sodium excretory and renal blood flow effects of angiotensin converting enzyme inhibition.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Differential Threshold; Diuresis; Hemodynamics; Imidazoles; Losartan; Natriuresis; Nephrectomy; Potassium; Ramipril; Rats; Rats, Wistar; Renal Circulation; Tetrazoles; Vasodilation | 1995 |
Nonpeptide angiotensin II receptor antagonists: in vivo inhibition of [125I-Sar1,Ile8]angiotensin II binding by losartan, EXP597 and L-159,282 in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetrazoles | 1996 |
Effects of the selective angiotensin II receptor antagonists losartan and PD123177 in animal models of anxiety and memory.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anti-Anxiety Agents; Anxiety; Biphenyl Compounds; Diazepam; Dose-Response Relationship, Drug; Imidazoles; Losartan; Male; Memory; Motor Activity; Pyridines; Rats; Rats, Sprague-Dawley; Scopolamine; Tetrazoles | 1996 |
Interactions of nonpeptide angiotensin II receptor antagonists at imidazoline/guanidinium receptor sites in rat forebrain.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Autoradiography; Biphenyl Compounds; Imidazoles; Losartan; Prosencephalon; Rats; Rats, Sprague-Dawley; Tetrazoles | 1996 |
Modulation of ANF-R2/ANP-C receptors by angiotensin II in vascular smooth muscle cells.
Topics: Adenylyl Cyclases; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cells, Cultured; Guanylate Cyclase; Imidazoles; Immunoblotting; Losartan; Muscle, Smooth, Vascular; Protein Kinase C; Rats; Receptors, Atrial Natriuretic Factor; Staurosporine; Tetrazoles | 1996 |
Effects of angiotensin II and its blockers Sar1-Ile8-angiotensin II and DuP 753 on drinking in ducks in relation to properties of subfornical organ neurons.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Drinking; Ducks; Hematocrit; Imidazoles; Losartan; Neurons; Osmolar Concentration; Receptors, Angiotensin; Saline Solution, Hypertonic; Subfornical Organ; Tetrazoles; Vasotocin | 1996 |
Evidence for angiotensin IV receptors in human collecting duct cells.
Topics: Aminopeptidases; Angiotensin II; Angiotensin Receptor Antagonists; Binding, Competitive; Biphenyl Compounds; Blotting, Northern; Calcium; CD13 Antigens; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Imidazoles; Kidney Tubules, Collecting; Leucine; Losartan; Pyridines; Receptors, Angiotensin; RNA, Messenger; Tetrazoles | 1996 |
Angiotensin II activation of protein kinase C decreases delayed rectifier K+ current in rabbit vascular myocytes.
Topics: Alkaloids; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzophenanthridines; Biphenyl Compounds; Calcium; Enzyme Activation; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Ion Transport; Isoenzymes; Kinetics; Losartan; Membrane Potentials; Muscle, Smooth, Vascular; Naphthalenes; Phenanthridines; Portal Vein; Potassium; Protein Kinase C; Rabbits; Signal Transduction; Tetrazoles | 1996 |
Reduction by (-)-cicletanine of the vascular reactivity to angiotensin II in rats.
Topics: Administration, Oral; Angiotensin II; Animals; Antihypertensive Agents; Aorta, Thoracic; Biphenyl Compounds; Blood Pressure; Decerebrate State; Imidazoles; In Vitro Techniques; Injections, Intravenous; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Pyridines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stereoisomerism; Tetrazoles; Vasoconstrictor Agents; Vasopressins | 1996 |
Renin-angiotensin system modulates renal bradykinin production.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Bradykinin; Cyclic GMP; Dinoprostone; Dogs; Drug Combinations; Extracellular Space; Female; Hemodynamics; Imidazoles; Kidney; Losartan; Microdialysis; Oligopeptides; Renal Circulation; Renin-Angiotensin System; Tetrazoles | 1996 |
The role of brain angiotensin in thirst and AVP release induced by hemorrhage.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Blood Volume; Captopril; Cohort Studies; Colony-Stimulating Factors; Drinking; Hemorrhage; Hypothalamus; Imidazoles; Injections, Intraperitoneal; Injections, Intraventricular; Losartan; Male; Oligopeptides; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Recombinant Proteins; Tetrazoles; Thirst; Time Factors; Vasopressins | 1996 |
Neuronal responses to iontophoretically applied angiotensin II, losartan and aldosterone, as well as gustatory stimuli, in non-anesthetized control and desoxycorticosterone acetate-pretreated rats.
Topics: Aldosterone; Angiotensin II; Animals; Biphenyl Compounds; Cohort Studies; Desoxycorticosterone; Electrophysiology; Imidazoles; Iontophoresis; Losartan; Male; Neural Conduction; Neurons, Afferent; Prosencephalon; Rats; Rats, Wistar; Taste; Tetrazoles | 1996 |
Effects of DOCA pretreatment on neuronal sensitivity and cell responsiveness to angiotensin II, in the bed nucleus of the stria terminalis in the rat.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Desoxycorticosterone; Electrophysiology; Imidazoles; Iontophoresis; Losartan; Male; Pyridines; Rats; Rats, Wistar; Sensitivity and Specificity; Tetrazoles; Thalamic Nuclei | 1996 |
Angiotensin II receptor subtype antagonists can both stimulate and inhibit salt appetite in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Appetite Regulation; Biphenyl Compounds; Desoxycorticosterone; Drinking Behavior; Imidazoles; Injections, Intraventricular; Losartan; Male; Rats; Rats, Wistar; Saline Solution, Hypertonic; Sodium Chloride; Tetrazoles; Time Factors | 1996 |
Intracellular Ca2+ modulation by angiotensin II and endothelin-1 in cardiomyocytes and fibroblasts from hypertrophied hearts of spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Body Weight; Calcium; Endothelin-1; Fibroblasts; Heart; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Species Specificity; Tetrazoles; Vasoconstrictor Agents; Viper Venoms | 1996 |
Pharmacodynamic, pharmacokinetic and clinical profile of the first orally active angiotensin II receptor antagonist.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Tetrazoles | 1995 |
Modulation by locally produced luminal angiotensin II of proximal tubular sodium reabsorption via an AT1 receptor.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Imidazoles; Kidney Tubules, Proximal; Losartan; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Sodium; Tetrazoles | 1996 |
Angiotensin II receptor type 1 on granulosa and thecal cells of rabbit preovulatory follicles.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding Sites; Biphenyl Compounds; Cells, Cultured; Chorionic Gonadotropin; Female; Gonadotropins, Equine; Granulosa Cells; Imidazoles; Kinetics; Losartan; Pyridines; Rabbits; Receptors, Angiotensin; Saralasin; Tetrazoles; Theca Cells; Up-Regulation | 1996 |
The angiotensin II type 2 receptor primarily inhibits cell growth via pertussis toxin-sensitive G proteins.
Topics: 3T3 Cells; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Biphenyl Compounds; Cell Division; GTP-Binding Proteins; Imidazoles; Kinetics; Losartan; Mice; Oligopeptides; Pertussis Toxin; Rats; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Recombinant Proteins; Tetrazoles; Transfection; Virulence Factors, Bordetella | 1996 |
Angiotensin II receptors involved in the enhancement of noradrenergic transmission in the caudal artery of the spontaneously hypertensive rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arteries; Biphenyl Compounds; Imidazoles; In Vitro Techniques; Losartan; Norepinephrine; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Tetrazoles; Vasoconstriction | 1996 |
Multiple prejunctional actions of angiotensin II on noradrenergic transmission in the caudal artery of the rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arteries; Biphenyl Compounds; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Indomethacin; Losartan; Male; NG-Nitroarginine Methyl Ester; Norepinephrine; Pyridines; Rats; Rats, Sprague-Dawley; Tetrazoles; Vasoconstriction | 1996 |
Effects of non-peptide angiotensin II-receptor antagonists on pentylenetetrazol kindling in mice.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anticonvulsants; Biphenyl Compounds; Convulsants; Drug Evaluation, Preclinical; Imidazoles; Injections, Intraventricular; Kindling, Neurologic; Losartan; Male; Mice; Pentylenetetrazole; Pyridines; Seizures; Tetrazoles | 1996 |
The angiotensin AT2 receptor is present in the human fetal adrenal gland throughout the second trimester of gestation.
Topics: Adrenal Glands; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Autoradiography; Binding, Competitive; Biphenyl Compounds; Cells, Cultured; Female; Fetus; Gestational Age; Humans; Imidazoles; In Vitro Techniques; Kinetics; Losartan; Pregnancy; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles; Tissue Distribution | 1996 |
Exaggerated tubuloglomerular feedback activity in genetic hypertension is mediated by ANG II and AT1 receptors.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Feedback; Hypertension; Imidazoles; Kidney Glomerulus; Kidney Tubules; Loop of Henle; Losartan; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Receptors, Angiotensin; Renal Circulation; Tetrazoles | 1996 |
The effect of angiotensin II receptor antagonists on diethylstilbestrol-induced vascular changes in the rat anterior pituitary gland: a quantitative evaluation.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Diethylstilbestrol; Drug Implants; Imidazoles; Losartan; Male; Microcirculation; Pituitary Gland, Anterior; Pyridines; Rats; Rats, Inbred F344; Silicone Elastomers; Tetrazoles | 1996 |
Effects of losartan on cerebral arteries in stroke-prone spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cerebral Arteries; Cerebrovascular Disorders; Endothelium, Vascular; Hypertension; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Tetrazoles | 1996 |
Antinociceptive effects of angiotensin-converting enzyme inhibitors and an angiotensin II receptor antagonist in mice.
Topics: Administration, Oral; Analgesics; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Brain; Enalapril; Imidazoles; Indoles; Losartan; Male; Mice; Naloxone; Pain Measurement; Peptidyl-Dipeptidase A; Receptors, Angiotensin; Tetrazoles | 1996 |
Inhibition of aminopeptidase A activity causes an acute albuminuria in mice: an angiotensin II-mediated effect?
Topics: Acute Disease; Albuminuria; Aminopeptidases; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Enalapril; Glutamyl Aminopeptidase; Histocytochemistry; Imidazoles; In Situ Hybridization; Losartan; Mice; Mice, Inbred BALB C; Tetrazoles | 1996 |
Osteopontin is produced by rat cardiac fibroblasts and mediates A(II)-induced DNA synthesis and collagen gel contraction.
Topics: Angiotensin II; Animals; Antibodies, Blocking; Antibodies, Monoclonal; Biphenyl Compounds; Blotting, Northern; Cells, Cultured; Collagen; DNA; Fibroblasts; Hypertension, Renovascular; Hypertrophy, Left Ventricular; Imidazoles; Immunohistochemistry; Integrins; Losartan; Myocardium; Oligopeptides; Osteopontin; Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sialoglycoproteins; Tetrazoles; Wound Healing | 1996 |
Angiotensin II and bladder obstruction in the rat: influence on hypertrophic growth and contractility.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Female; Hypertrophy; Imidazoles; Losartan; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Organ Size; Rats; Rats, Sprague-Dawley; Tetrazoles; Urinary Bladder; Urinary Bladder Neck Obstruction | 1996 |
Effect of luminal angiotensin II and ANP on early and late cortical distal tubule HCO3- reabsorption.
Topics: Absorption; Amiloride; Angiotensin II; Animals; Anti-Bacterial Agents; Atrial Natriuretic Factor; Bicarbonates; Biphenyl Compounds; Enzyme Inhibitors; Imidazoles; Kidney Cortex; Kidney Tubules, Distal; Losartan; Macrolides; Male; Rats; Rats, Wistar; Tetrazoles | 1996 |
[Contribution of the renin-angiotensin system to the variability of blood pressure in hypertensive rat after blockade of nitric oxide synthesis].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Heart Rate; Hypertension; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Renin-Angiotensin System; Tetrazoles | 1996 |
No evidence for involvement of angiotensin II in spatial learning in water maze in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Cholinergic Antagonists; Diazepam; GABA Modulators; Imidazoles; Injections, Intraventricular; Losartan; Maze Learning; Memory; Organophosphorus Compounds; Proline; Psychomotor Performance; Rats; Renin; Scopolamine; Tetrazoles | 1996 |
Angiotensin II, via an action at AT1 receptors, may modulate the behavioural effects of ET-1 in conscious rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Behavior, Animal; Biphenyl Compounds; Drug Synergism; Endothelin-1; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1996 |
Altered signal transduction system in hypertrophied myocardium: angiotensin II stimulates collagen synthesis in hypertrophied hearts.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Cardiomegaly; Cells, Cultured; Collagen; Fibroblasts; Imidazoles; Losartan; Male; Myocardium; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin-Angiotensin System; RNA, Messenger; Saralasin; Signal Transduction; Tetrazoles | 1996 |
Brain "ouabain" and angiotensin II in salt-sensitive hypertension in spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Brain; Guanabenz; Hemodynamics; Hypertension; Imidazoles; Immunoglobulin Fab Fragments; Injections, Intraventricular; Losartan; Male; Ouabain; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Sodium Chloride, Dietary; Tetrazoles | 1996 |
Hypertension in obese Zucker rats. Role of angiotensin II and adrenergic activity.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Hemodynamics; Imidazoles; Infusions, Intravenous; Kidney; Losartan; Male; Obesity; Prazosin; Rats; Rats, Zucker; Renin; Renin-Angiotensin System; Sodium Chloride, Dietary; Sympathetic Nervous System; Tetrazoles | 1996 |
[Angiotensin II antagonists: a distinct therapeutic class].
Topics: Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Tetrazoles | 1996 |
Effects of chronic central administration of losartan on the cardiovascular and hormonal responses to hemorrhage in conscious rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Arginine Vasopressin; Biphenyl Compounds; Blood Pressure; Brain; Cardiovascular System; Epinephrine; Heart Rate; Hemorrhage; Hormones; Imidazoles; Injections, Intraventricular; Losartan; Male; Norepinephrine; Rats; Rats, Wistar; Renin; Tetrazoles; Time Factors | 1996 |
Pharmacological modulation of spontaneous renal blood flow dynamics.
Topics: Anesthetics, Inhalation; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Bumetanide; Diuretics; Drug Interactions; Feedback; Furosemide; Halothane; Imidazoles; Isoflurane; Kidney Glomerulus; Kidney Tubules; Losartan; Male; Natriuresis; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Renal Circulation; Tetrazoles; Vasoconstrictor Agents | 1996 |
Angiotensin II receptors in the human adrenal gland.
Topics: Adrenal Glands; Adult; Aging; Angiotensin II; Angiotensin Receptor Antagonists; Autoradiography; Binding, Competitive; Biphenyl Compounds; Gestational Age; Humans; Imidazoles; Losartan; Middle Aged; Pyridines; Receptors, Angiotensin; Tetrazoles; Tissue Distribution | 1996 |
AT1 receptors and cell proliferation in rat adrenals: effects of angiotensin infusion, low sodium diet and losartan.
Topics: Adrenal Glands; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cell Division; Imidazoles; Losartan; Male; Rats; Rats, Wistar; Receptors, Angiotensin; Sodium, Dietary; Tetrazoles | 1996 |
Tissue-specific regulation of angiotensin-converting enzyme by angiotensin II and losartan in the rat.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Imidazoles; Losartan; Male; Organ Specificity; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Tetrazoles; Vasoconstrictor Agents | 1996 |
p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta; Biphenyl Compounds; Blood Pressure; Diabetes Mellitus, Experimental; Hydralazine; Imidazoles; In Situ Hybridization; Losartan; Male; Membrane Transport Proteins; NADPH Dehydrogenase; NADPH Oxidases; Phosphoproteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxide Dismutase; Systole; Tetrazoles | 1997 |
Combined inhibition of endothelin and angiotensin II receptors blocks volume load-induced cardiac hormone release.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atrial Function, Right; Atrial Natriuretic Factor; Biphenyl Compounds; Blood Volume; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hemodynamics; Hormones; Imidazoles; Losartan; Male; Myocardium; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Peptides, Cyclic; Plasma Substitutes; Pressure; Protein Precursors; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetrazoles | 1997 |
Temporal differences between the involvement of angiotensin II and endothelin in the cardiovascular responses to endotoxaemia in conscious rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine Vasopressin; Biphenyl Compounds; Captopril; Endothelins; Endotoxemia; Hemodynamics; Imidazoles; Indans; Lipopolysaccharides; Losartan; Male; Rats; Renal Circulation; Tetrazoles; Vasopressins | 1996 |
The active state of the AT1 angiotensin receptor is generated by angiotensin II induction.
Topics: Amino Acid Sequence; Angiotensin II; Animals; Binding Sites; COS Cells; Imidazoles; Kinetics; Losartan; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Protein Structure, Secondary; Rats; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Tetrazoles; Transfection | 1996 |
Role of AT1 receptors in the central control of sympathetic vasomotor function.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Cardiac Output; Dose-Response Relationship, Drug; Female; Heart Rate; Imidazoles; Injections, Intraventricular; Kidney; Laser-Doppler Flowmetry; Losartan; Male; Medulla Oblongata; Pressoreceptors; Rabbits; Receptors, Angiotensin; Species Specificity; Tetrazoles | 1996 |
Presence of angiotensin II AT2 receptor binding sites in the adventitia of human kidney vasculature.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Autoradiography; Binding, Competitive; Biphenyl Compounds; Carcinoma, Renal Cell; Humans; Imidazoles; Kidney; Kidney Glomerulus; Kidney Tubules, Proximal; Losartan; Pyridines; Tetrazoles; Tunica Media | 1996 |
HR 720, a novel angiotensin receptor antagonist inhibits the angiotensin II-induced trophic effects, fibronectin release and fibronectin-EIIIA+ expression in rat aortic vascular smooth muscle cells in vitro.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Biphenyl Compounds; Cells, Cultured; Fibronectins; Imidazoles; Leucine; Losartan; Male; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetrazoles | 1997 |
ANG II chronically supports renal and lumbar sympathetic activity in sodium-deprived, conscious rats.
Topics: Adrenergic alpha-Agonists; Angiotensin II; Animals; Anti-Arrhythmia Agents; Biphenyl Compounds; Blood Pressure; Central Venous Pressure; Heart Rate; Imidazoles; Kidney; Losartan; Lumbosacral Region; Male; Methoxamine; Phenylephrine; Rats; Rats, Sprague-Dawley; Sodium; Sympathetic Nervous System; Tetrazoles; Time Factors | 1996 |
Losartan (Cozaar)
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Renin-Angiotensin System; Tetrazoles | 1996 |
The angiotensin type 2 receptor mediates RNA synthesis in A10 vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Cell Division; Cell Line; Imidazoles; Losartan; Muscle, Smooth, Vascular; Pyridines; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA; Signal Transduction; Tetrazoles | 1996 |
[Angiotensin-II receptor blockers].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Receptors, Angiotensin; Renin-Angiotensin System; Tetrazoles | 1996 |
Angiotensin II stimulates the proliferation of osteoblast-rich populations of cells from rat calvariae.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Biphenyl Compounds; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Enzyme Activation; Humans; Imidazoles; Inositol 1,4,5-Trisphosphate; Kinetics; Losartan; Osteoblasts; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Skull; Tetrazoles | 1997 |
Characterization of the decline in alcohol consumption by aminopeptidase inhibition.
Topics: Alcohol Drinking; Aminopeptidases; Angiotensin II; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Drinking Behavior; Enkephalins; Imidazoles; Leucine; Losartan; Male; Naltrexone; Rats; Rats, Wistar; Tetrazoles | 1996 |
Involvement of MAP kinase in angiotensin II-induced phosphorylation and intracellular targeting of neuronal AT1 receptors.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Animals; Biological Transport; Biphenyl Compounds; Brain Stem; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Hypothalamus; Imidazoles; Losartan; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Phosphorylation; Plant Proteins; Protein Processing, Post-Translational; Rats; Rats, Inbred WKY; Signal Transduction; Tetrazoles | 1997 |
Candesartan (CV-11974) dissociates slowly from the angiotensin AT1 receptor.
Topics: Adrenal Cortex; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Cattle; Imidazoles; In Vitro Techniques; Losartan; Male; Rabbits; Receptors, Angiotensin; Tetrazoles; Vasoconstriction | 1997 |
In vitro and in vivo effects of UP 269-6, a new potent orally active nonpeptide angiotensin II receptor antagonist, on vascular smooth muscle cell proliferation.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Carotid Arteries; Carotid Artery Injuries; Catheterization; Cell Division; Imidazoles; In Vitro Techniques; Losartan; Muscle Proteins; Muscle, Smooth, Vascular; Pyrimidines; Rats; Rats, Inbred SHR; Rats, Wistar; Stimulation, Chemical; Tetrazoles | 1997 |
Angiotensin II-induced pulmonary edema in a rabbit model.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Imidazoles; Infusions, Intravenous; Injections, Intravenous; Losartan; Male; Pulmonary Edema; Rabbits; Tetrazoles | 1997 |
An hypothesis for the interpretation of the contractile response of vascular smooth muscle at the cellular level.
Topics: Angiotensin II; Animals; Anti-Arrhythmia Agents; Aorta, Thoracic; Biphenyl Compounds; Cells, Cultured; Imidazoles; Isradipine; Losartan; Muscle Contraction; Muscle, Smooth, Vascular; Potassium Chloride; Rats; Serotonin; Tetrazoles | 1996 |
Increased brain transcription factor expression by angiotensin in genetic hypertension.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine Vasopressin; Biphenyl Compounds; Blood Pressure; Brain; DNA-Binding Proteins; Early Growth Response Protein 1; Hypertension; Imidazoles; Immediate-Early Proteins; Immunohistochemistry; Injections, Intraventricular; Losartan; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Tetrazoles; Transcription Factors | 1997 |
Effect of angiotensin receptor blockade in the rabbit aorta: influence of the endothelium.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Biphenyl Compounds; Enalapril; Endothelium, Vascular; Imidazoles; Losartan; Male; Pyridines; Rabbits; Receptors, Angiotensin; Tetrazoles | 1996 |
Heme oxygenase-1 is regulated by angiotensin II in rat vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Cells, Cultured; Down-Regulation; Heme Oxygenase (Decyclizing); Imidazoles; Losartan; Male; Muscle, Smooth, Vascular; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetrazoles; Vasoconstrictor Agents | 1997 |
The pharmacologic profile of 606A, a novel angiotensin II receptor antagonist.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Cattle; Dogs; Female; Guinea Pigs; Imidazoles; Losartan; Male; Rabbits; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Tetrazoles; Vasoconstriction | 1997 |
Regulation of angiotensin II receptor AT1 subtypes in renal afferent arterioles during chronic changes in sodium diet.
Topics: Actins; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Cloning, Molecular; Culture Techniques; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enalaprilat; Gene Expression Regulation; Imidazoles; Kidney; Losartan; Male; Oligopeptides; Polymerase Chain Reaction; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Renal Artery; Renal Circulation; Ribonucleases; RNA, Messenger; Sodium, Dietary; Tetrazoles; Vasoconstrictor Agents | 1997 |
ANG II modifies cardiomyocyte function via extracardiac and intracardiac neurons: in situ and in vitro studies.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Calcium; Cells, Cultured; Coculture Techniques; Coronary Circulation; Dogs; Female; Ganglia, Sympathetic; Guinea Pigs; Heart; Heart Ventricles; Imidazoles; Losartan; Male; Myocardial Contraction; Neurons; Pyridines; Stellate Ganglion; Tetrazoles; Timolol | 1997 |
Inhibition of nitric oxide synthase causes cardiac phenotypic modulation in rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blotting, Northern; Collagen; Contractile Proteins; DNA Probes; Enzyme Inhibitors; Gene Expression Regulation; Heart; Imidazoles; Losartan; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organ Size; Phenotype; Rats; Rats, Wistar; RNA; Tetrazoles | 1997 |
Angiotensin II receptor type I-regulated anion secretion in cystic fibrosis pancreatic duct cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Angiotensin II; Angiotensin Receptor Antagonists; Antiporters; Bicarbonates; Biological Transport, Active; Biphenyl Compounds; Calcium; Cell Polarity; Cells, Cultured; Chloride-Bicarbonate Antiporters; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Imidazoles; Intracellular Fluid; Ion Transport; Losartan; Microscopy, Confocal; Nystatin; Pancreatic Ducts; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Secretory Rate; Tetrazoles | 1997 |
Characterization of angiotensin II-regulated K+ conductance in rat adrenal glomerulosa cells.
Topics: Aldosterone; Angiotensin II; Animals; Biphenyl Compounds; Cells, Cultured; Cesium; Female; Imidazoles; Ion Transport; Losartan; Membrane Potentials; Nystatin; Patch-Clamp Techniques; Potassium; Potassium Channels; Quinidine; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetrazoles; Zona Glomerulosa | 1997 |
Angiotensin II activates distinct signal transduction pathways in astrocytes isolated from neonatal rat brain.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Astrocytes; Biphenyl Compounds; Bradykinin; Brain; Cells, Cultured; Cerebellum; Cerebral Cortex; Epoprostenol; Humans; Hypothalamus; Imidazoles; Losartan; Medulla Oblongata; Peptide Fragments; Phosphatidylinositol Diacylglycerol-Lyase; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetrazoles; Type C Phospholipases | 1997 |
Cardiovascular effects produced by microinjection of angiotensins and angiotensin antagonists into the ventrolateral medulla of freely moving rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Heart Rate; Imidazoles; Losartan; Male; Medulla Oblongata; Microinjections; Oligopeptides; Peptide Fragments; Rats; Rats, Wistar; Tetrazoles; Time Factors | 1997 |
Video-microscopic assessment of the role of tissue angiotensin-converting enzyme in the control of the renal microcirculation.
Topics: Angiotensin I; Angiotensin II; Animals; Arterioles; Biphenyl Compounds; Imidazoles; Indoles; Kidney; Losartan; Male; Microscopy, Video; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Tetrazoles; Vasoconstriction | 1997 |
Angiotensin II receptor blockade and myocardial fibrosis of the infarcted rat heart.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Fibrosis; Imidazoles; Losartan; Male; Myocardial Infarction; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1997 |
Cloning and expression of angiotensin II type 2 (AT2) receptors from murine neuroblastoma N1E-115 cells: evidence for AT2 receptor heterogeneity.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cell Membrane; Cloning, Molecular; COS Cells; Dithiothreitol; DNA, Complementary; Imidazoles; Locus Coeruleus; Losartan; Mice; Neuroblastoma; Oligopeptides; Olivary Nucleus; Polymerase Chain Reaction; Pyridines; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Recombinant Proteins; Tetrazoles; Transfection; Tumor Cells, Cultured | 1997 |
Modulation of renal glomerular angiotensin II receptors by ace inhibition and AT1 receptor antagonism.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Binding, Competitive; Biphenyl Compounds; Captopril; Heart; Imidazoles; Kidney Glomerulus; Losartan; Male; Membrane Proteins; Organ Size; Peptidyl-Dipeptidase A; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin; Renin-Angiotensin System; Tetrazoles | 1997 |
Angiotensin II- and IV-induced changes in cerebral blood flow. Roles of AT1, AT2, and AT4 receptor subtypes.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Flow Velocity; Blood Pressure; Cerebrovascular Circulation; Female; Imidazoles; Laser-Doppler Flowmetry; Losartan; Male; Microcirculation; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles | 1997 |
Tissue angiotensin II as a modulator of erectile function. I. Angiotensin peptide content, secretion and effects in the corpus cavernosum.
Topics: Alprostadil; Anesthesia; Angiotensin II; Animals; Dogs; Humans; Injections; Losartan; Male; Papaverine; Penile Erection; Penis | 1997 |
Losartan inhibition of angiotensin-related drinking and Fos immunoreactivity in hypertensive and hypotensive contexts.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Dose-Response Relationship, Drug; Drinking; Imidazoles; Losartan; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Tetrazoles | 1996 |
Brain angiotensinergic pathways mediate renal nerve inhibition by central hypertonic NaCl in conscious sheep.
Topics: Angiotensin II; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Brain; Female; Imidazoles; Injections, Intraventricular; Kidney; Losartan; Neural Inhibition; Neural Pathways; Pressoreceptors; Saline Solution, Hypertonic; Sheep; Sodium; Sympathetic Nervous System; Tetrazoles | 1997 |
Angiotensin IV stimulates the proliferation of rat anterior pituitary cells in vitro.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cell Division; Cells, Cultured; Imidazoles; Losartan; Male; Pituitary Gland, Anterior; Pyridines; Rats; Rats, Wistar; Tetrazoles; Thymidine | 1997 |
Hypotensive effects of the angiotensin II antagonist telmisartan in conscious chronically-instrumented transgenic rats.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Genetically Modified; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Blood Pressure; Captopril; Heart Rate; Imidazoles; Losartan; Rats; Telmisartan; Tetrazoles | 1996 |
Tranilast antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anticoagulants; Antihypertensive Agents; Aorta, Thoracic; Becaplermin; Biphenyl Compounds; Calcium; Calcium Channel Blockers; Cells, Cultured; Humans; Imidazoles; Inositol Phosphates; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; ortho-Aminobenzoates; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rabbits; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1996 |
Postrenal transplant erythrosis: a direct role for angiotensin II.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Female; Humans; Imidazoles; Kidney Transplantation; Losartan; Male; Polycythemia Vera; Postoperative Complications; Tetrazoles | 1997 |
Angiotensin receptor antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Scleroderma, Systemic; Tetrazoles | 1997 |
Intracerebroventricular losartan inhibits postprandial drinking in sheep.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Carotid Arteries; Cerebral Ventricles; Drinking Behavior; Female; Imidazoles; Infusions, Intra-Arterial; Infusions, Intravenous; Infusions, Parenteral; Losartan; Postprandial Period; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Saline Solution, Hypertonic; Sheep; Tetrazoles; Water-Electrolyte Balance | 1997 |
Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Enalapril; Hexamethonium; Imidazoles; Kidney; Losartan; Mice; Mice, Knockout; Phentolamine; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Renin; RNA, Messenger; Sympatholytics; Tetrazoles; Time Factors; Transcription, Genetic | 1997 |
Angiotensin II requires PDGF-BB to induce DNA synthesis in rat mesangial cells cultured in an exogenous insulin-free medium.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Becaplermin; Biphenyl Compounds; Cell Division; Cells, Cultured; Culture Media; DNA; Drug Synergism; Fibroblast Growth Factor 2; Glomerular Mesangium; Glomerulonephritis; Imidazoles; Insulin; Losartan; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Tetrazoles | 1997 |
Trophic effect of angiotensin II in neonatal rat cardiomyocytes: role of endothelin-1 and non-myocyte cells.
Topics: Angiotensin II; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Biphenyl Compounds; Cell Adhesion; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Endothelins; GTP-Binding Proteins; Heart; Imidazoles; Inositol; Inositol Phosphates; Isotope Labeling; Losartan; Myocardium; Peptide Fragments; Peptides, Cyclic; Pertussis Toxin; Phenylalanine; Rats; Rats, Wistar; Tetrazoles; Vasoconstrictor Agents; Virulence Factors, Bordetella | 1997 |
Use of pulsed-wave Doppler echocardiography to measure changes in MPAP. Is further validation required?
Topics: Acute Disease; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Captopril; Echocardiography, Doppler, Pulsed; Heart; Humans; Hypertension, Pulmonary; Hypoxia; Imidazoles; Losartan; Lung Diseases, Obstructive; Pulmonary Artery; Pulmonary Heart Disease; Rats; Renin-Angiotensin System; Reproducibility of Results; Tetrazoles; Vasoconstriction | 1997 |
Angiotensin II induces apoptosis of adult ventricular myocytes in vitro.
Topics: Alkaloids; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Apoptosis; Benzophenanthridines; Biphenyl Compounds; Calcimycin; Calcium; Cells, Cultured; Chelating Agents; Cytosol; Egtazic Acid; Enzyme Inhibitors; Imidazoles; Ionophores; Isoenzymes; Losartan; Myocardium; Phenanthridines; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles | 1997 |
Angiotensin II type 1 receptor expression in human breast tissues.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antibodies, Monoclonal; Antihypertensive Agents; Binding Sites; Binding, Competitive; Biphenyl Compounds; Breast; Breast Neoplasms; Electrophoresis, Polyacrylamide Gel; Female; Humans; Imidazoles; Immunohistochemistry; Losartan; Oligopeptides; Receptors, Angiotensin; Tetrazoles | 1997 |
Comparative vasoconstrictor effects of angiotensin II, III, and IV in human isolated saphenous vein.
Topics: Aged; Aged, 80 and over; Aminopeptidases; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Anti-Bacterial Agents; Antihypertensive Agents; Biphenyl Compounds; Dose-Response Relationship, Drug; Drug Synergism; Female; Glutamyl Aminopeptidase; Humans; Imidazoles; In Vitro Techniques; Losartan; Male; Metalloendopeptidases; Methionyl Aminopeptidases; Middle Aged; Muscle Contraction; Muscle, Smooth, Vascular; Peptides; Protease Inhibitors; Pyridines; Saphenous Vein; Tachyphylaxis; Tetrazoles; Vasoconstrictor Agents | 1997 |
Angiotensin-responsive adrenal glomerulosa cell proteins: characterization by protease mapping, species comparison, and specific angiotensin receptor antagonists.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Bucladesine; Cattle; Cells, Cultured; Chymotrypsin; Imidazoles; Losartan; Male; Methionine; Peptide Mapping; Protein Biosynthesis; Proteins; Pyridines; Rats; Rats, Sprague-Dawley; Species Specificity; Sulfur Radioisotopes; Tetrazoles; Zona Glomerulosa | 1997 |
Effects of chronic losartan treatment on vascular reactivity in normotensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Biphenyl Compounds; Blood Pressure; Drug Interactions; Imidazoles; In Vitro Techniques; Losartan; Male; Mesenteric Arteries; Phenylephrine; Potassium; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Tetrazoles; Vasoconstriction | 1997 |
Pressure-independent effects of AT1-receptor antagonism on cardiovascular remodeling in aortic-banded rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Biphenyl Compounds; Blood Pressure; Cardiomegaly; Constriction; Coronary Circulation; Coronary Vessels; Heart; Imidazoles; Losartan; Male; Organ Size; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles; Vascular Resistance | 1997 |
Effects of enalapril, losartan, and verapamil on blood pressure and glucose metabolism in the Cohen-Rosenthal diabetic hypertensive rat.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus, Experimental; Disease Models, Animal; Enalapril; Glucose; Hypertension; Imidazoles; Losartan; Male; Rats; Rats, Inbred Strains; Tetrazoles; Verapamil | 1997 |
Adrenomedullin is a potent inhibitor of angiotensin II-induced migration of human coronary artery smooth muscle cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenomedullin; Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Cell Movement; Cells, Cultured; Coronary Vessels; Dose-Response Relationship, Drug; Humans; Imidazoles; Losartan; Muscle, Smooth, Vascular; Peptides; Tetrazoles; Vasodilator Agents | 1997 |
Interaction of nitric oxide and the renin angiotensin system in renal hypertensive rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Enzyme Inhibitors; Heart Rate; Hypertension, Renovascular; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Renin; Renin-Angiotensin System; Tetrazoles; Vasoconstrictor Agents | 1997 |
Paraventricular nucleus administration of DuP753 or PD123319 inhibits the effects of angiotensin on water and sodium intake.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Drinking; Imidazoles; Losartan; Male; Paraventricular Hypothalamic Nucleus; Pyridines; Rats; Rats, Sprague-Dawley; Sodium, Dietary; Tetrazoles | 1996 |
Endothelial dysfunction in spontaneously hypertensive rats: consequences of chronic treatment with losartan or captopril.
Topics: Acetylcholine; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aorta, Thoracic; Biphenyl Compounds; Blood Pressure; Captopril; Endothelium, Vascular; Hypertension; Imidazoles; In Vitro Techniques; Losartan; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Superoxide Dismutase; Tetrazoles; Vasoconstriction; Vasodilation | 1997 |
The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Cyclic GMP; Enzyme Inhibitors; Extracellular Space; Female; Imidazoles; Indazoles; Kidney; Losartan; Microdialysis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin-Angiotensin System; Sodium; Tetrazoles | 1997 |
Losartan does not influence the blood platelet aggregation in normotensive rats.
Topics: Adenosine Diphosphate; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Collagen; Imidazoles; Losartan; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Reference Values; Tetrazoles | 1996 |
Atypical angiotensin II receptors coupled to phosphoinositide turnover/calcium signalling in catfish hepatocytes.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Biphenyl Compounds; Calcium; Cell Membrane; Egtazic Acid; Humans; Ictaluridae; Imidazoles; Liver; Losartan; Phosphatidylinositols; Pyridines; Receptors, Angiotensin; Signal Transduction; Tetrazoles | 1997 |
Regulation of thrombospondin-1 production by angiotensin II in rat heart endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blotting, Northern; Cell Line; Cycloheximide; Dactinomycin; Endothelium; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Losartan; Membrane Glycoproteins; Myocardium; Protein Kinase C; Pyridines; Rats; Tetrazoles; Thrombospondins | 1997 |
G protein-coupled receptors control vascular smooth muscle cell proliferation via pp60c-src and p21ras.
Topics: Angiotensin II; Animals; Antibodies; Aorta; Becaplermin; Biphenyl Compounds; Cell Division; Cells, Cultured; DNA; Electroporation; Endothelin-1; GTP-Binding Proteins; Imidazoles; Kinetics; Losartan; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Proto-Oncogene Proteins p21(ras); Proto-Oncogene Proteins pp60(c-src); Rats; Receptors, Angiotensin; Receptors, Cell Surface; Receptors, Endothelin; Receptors, Platelet-Derived Growth Factor; Receptors, Thrombin; Tetrazoles; Thrombin | 1997 |
Role of endogenous angiotensin II on sympathetic reflexes in conscious rabbits.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Baroreflex; Biphenyl Compounds; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Female; Hemodynamics; Hypoxia; Imidazoles; Kidney; Losartan; Male; Nasopharynx; Pyridines; Rabbits; Reflex; Sympathetic Nervous System; Tetrazoles | 1997 |
Role of endogenous ANG II and AT1 receptors in regulating arterial baroreflex responses in newborn lambs.
Topics: Angiotensin II; Animals; Animals, Newborn; Antihypertensive Agents; Arteries; Baroreflex; Biphenyl Compounds; Cardiovascular Physiological Phenomena; Imidazoles; Losartan; Phenylephrine; Receptors, Angiotensin; Sheep; Tetrazoles | 1997 |
Central infusion of the AT1 receptor antagonist losartan inhibits thirst but not sodium appetite in cattle.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Appetite; Behavior, Animal; Biphenyl Compounds; Brain; Cattle; Cerebrospinal Fluid; Dehydration; Drinking; Female; Hypertonic Solutions; Imidazoles; Injections, Intraventricular; Losartan; Pyridines; Sodium; Tetrazoles; Thirst; Water Deprivation | 1997 |
Role for endothelin-1 in angiotensin II-mediated hypertension.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Biphenyl Compounds; Blood Pressure; Dioxoles; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Imidazoles; In Vitro Techniques; Losartan; Male; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Serotonin; Staining and Labeling; Tetrazoles; Time Factors; Vasoconstrictor Agents | 1997 |
The effect of Losartan, an angiotensin II antagonist, on cardiac function, mass and morphology in rats after repeated hyperbaric exposures.
Topics: Adaptation, Physiological; Angiotensin II; Animals; Atmospheric Pressure; Biphenyl Compounds; Body Weight; Decompression; Heart; Heart Function Tests; Helium; Hypertrophy, Left Ventricular; Imidazoles; Losartan; Male; Myocardium; Nitrogen; Oxygen; Partial Pressure; Rats; Rats, Wistar; Tetrazoles | 1997 |
Characterization of the AT1 angiotensin II receptor expressed in guinea pig liver.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Binding, Competitive; Biphenyl Compounds; Enzyme Activation; Guinea Pigs; Imidazoles; Irbesartan; Liver; Losartan; Male; Polymerase Chain Reaction; Pyridines; Receptors, Angiotensin; RNA, Messenger; Tetrazoles | 1997 |
Effect of angiotensin II on a spinal nociceptive reflex in the rat: receptor and mechanism of action.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Drug Interactions; Hot Temperature; Imidazoles; Injections, Spinal; Losartan; Male; Naloxone; Neurokinin A; Neurokinin B; Nociceptors; Peptide Fragments; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord; Substance P; Tetrazoles | 1997 |
Role of brain angiotensin II in thirst and sodium appetite of sheep.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Appetite; Biphenyl Compounds; Brain; Cerebral Ventricles; Dehydration; Diet, Sodium-Restricted; Diuresis; Female; Imidazoles; Infusions, Parenteral; Losartan; Mannitol; Naphthyridines; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Saline Solution, Hypertonic; Saliva; Sheep; Sodium, Dietary; Tetrazoles; Thirst | 1997 |
Effects of captopril, losartan, and nifedipine on cell hypertrophy of cultured vascular smooth muscle from hypertensive Ren-2 transgenic rats.
Topics: Angiotensin II; Animals; Animals, Genetically Modified; Biphenyl Compounds; Captopril; Cells, Cultured; Hypertension; Hypertrophy; Imidazoles; Losartan; Muscle, Smooth, Vascular; Nifedipine; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Renin; Tetrazoles | 1997 |
Role of angiotensin in the dipsogenic effect of bradykinin in rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Animals; Biphenyl Compounds; Bradykinin; Brain; Captopril; Cerebral Ventricles; Drinking; Imidazoles; Immunohistochemistry; Losartan; Male; Peptidyl-Dipeptidase A; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Renin; Tetrazoles; Thirst | 1997 |
[Angiotensin II antagonist for heart insufficiency].
Topics: Adrenergic beta-Antagonists; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Biphenyl Compounds; Heart Failure; Humans; Imidazoles; Losartan; Prognosis; Tetrazoles | 1997 |
Angiotensin II and myocyte growth: role of fibroblasts.
Topics: Aging; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Biphenyl Compounds; Cell Division; Culture Media, Conditioned; Dose-Response Relationship, Drug; Fibroblasts; Imidazoles; Losartan; Myocardium; Rats; Rats, Wistar; Tetrazoles; Time Factors | 1997 |
Bimodal effects of angiotensin II on migration of human and rat smooth muscle cells. Direct stimulation and indirect inhibition via transforming growth factor-beta 1.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cell Movement; Gene Expression; Humans; Imidazoles; Losartan; Muscle, Smooth, Vascular; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Tetrazoles; Transforming Growth Factor beta | 1997 |
Losartan attenuates myocardial ischemia-induced ventricular arrythmias and reperfusion injury in spontaneously hypertensive rats.
Topics: Acute Disease; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Heart Rate; Hemodynamics; Losartan; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Inbred SHR | 1997 |
Renal effects of an angiotensin II antagonist in stroke-prone spontaneously hypertensive rat.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Body Weight; Cerebrovascular Disorders; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Imidazoles; Kidney; Kidney Function Tests; Kidney Glomerulus; Losartan; Organ Size; Proteinuria; Rats; Rats, Inbred SHR; Receptors, Angiotensin; Tetrazoles; Tissue Embedding | 1997 |
The effect of angiotensin II receptor antagonists on kidney function in two-kidney, two-clip Goldblatt hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Captopril; Hypertension, Renovascular; Kidney; Kidney Function Tests; Losartan; Male; Rats; Rats, Wistar | 1997 |
Baroreceptor-independent renal nerve inhibition by intracerebroventricular angiotensin II in conscious sheep.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Central Venous Pressure; Female; Imidazoles; Injections, Intraventricular; Kidney; Losartan; Neural Inhibition; Phenylephrine; Pressoreceptors; Sheep; Sympathetic Nervous System; Tetrazoles | 1997 |
Fibrous tissue and angiotensin II.
Topics: Actins; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Collagen; Connective Tissue; Croton Oil; Fibroblasts; Granuloma; Hydroxyproline; Imidazoles; Lisinopril; Losartan; Macrophages; Male; Peptidyl-Dipeptidase A; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Wound Healing | 1997 |
Angiotensin II-mediated growth and antigrowth effects in cultured neonatal rat cardiac myocytes and fibroblasts.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Cells, Cultured; Endothelin-1; Fibroblasts; Growth Inhibitors; Growth Substances; Heart; Imidazoles; Inositol Phosphates; Losartan; Myocardium; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin | 1997 |
Selective antagonism of the AT1 receptor inhibits angiotensin II stimulated DNA and protein synthesis in primary cultures of human proximal tubular cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Cells, Cultured; DNA; Humans; Imidazoles; Kidney Tubules, Proximal; Losartan; Protein Biosynthesis; Pyridines; Tetrazoles | 1997 |
On the mechanism of the losartan-mediated inhibition of phosphatidylcholine biosynthesis in H9c2 cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Cell Line; Cell Membrane; Choline; Cytosol; Imidazoles; Immunoblotting; Kinetics; Losartan; Phosphatidylcholines; Pyridines; Tetrazoles; Tritium | 1997 |
The type I angiotensin II receptor couples to Stat1 and Stat3 activation through Jak2 kinase in neonatal rat cardiac myocytes.
Topics: Angiotensin II; Animals; Animals, Newborn; Cells, Cultured; DNA-Binding Proteins; Heart; Imidazoles; Janus Kinase 2; Losartan; Myocardium; Nitriles; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; STAT1 Transcription Factor; STAT3 Transcription Factor; Tetrazoles; Trans-Activators; Transcription, Genetic; Tyrosine; Tyrphostins | 1997 |
In vitro pharmacological properties of KRH-594, a novel angiotensin II type 1 receptor antagonist.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Guinea Pigs; Ileum; In Vitro Techniques; Losartan; Male; Muscle Contraction; Rabbits; Tetrazoles; Thiadiazoles; Vasoconstrictor Agents | 1997 |
Effect of angiotensin II on corpus cavernosum smooth muscle in relation to nitric oxide environment: in vitro studies in canines.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Dogs; Electric Stimulation; Enzyme Inhibitors; Losartan; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Penis; Phenylephrine | 1997 |
Role of angiotensin II in early cardiovascular growth and vascular amplifier development in spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Antihypertensive Agents; Body Weight; Cardiomegaly; Cardiovascular System; Hypertension; Hypertrophy; Indoles; Kidney; Losartan; Male; Mesenteric Arteries; Organ Size; Papaverine; Perindopril; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Vascular Resistance | 1997 |
ANG II prolongs splanchnic nerve-mediated inhibition of duodenal mucosal alkaline secretion in the rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Bicarbonates; Biphenyl Compounds; Duodenum; Electric Stimulation; Enalapril; Hydrogen-Ion Concentration; Imidazoles; In Vitro Techniques; Intestinal Mucosa; Losartan; Male; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Splanchnic Nerves; Tetrazoles; Time Factors | 1997 |
The subtype 2 angiotensin receptor regulates renal prostaglandin F2 alpha formation in conscious rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Diet, Sodium-Restricted; Dinoprost; Dinoprostone; Extracellular Space; Female; Homeostasis; Imidazoles; Kidney; Losartan; Microdialysis; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Sodium, Dietary; Tetrazoles | 1997 |
Angiotensin II-induced hypertension increases heme oxygenase-1 expression in rat aorta.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Antioxidants; Aorta; Biphenyl Compounds; Blood Pressure; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hypertension; Imidazoles; Losartan; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Systole; Tetrazoles; Vasoconstrictor Agents | 1997 |
Hypercalcemia stimulates expression of intrarenal phospholipase A2 and prostaglandin H synthase-2 in rats. Role of angiotensin II AT1 receptors.
Topics: Angiotensin II; Animals; Blotting, Western; Calcium; Cyclooxygenase 1; Cyclooxygenase 2; Dihydrotachysterol; Dinoprostone; Fluorescent Antibody Technique; Hypercalcemia; Isoenzymes; Kidney; Kidney Cortex; Kidney Medulla; Losartan; Male; Membrane Proteins; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 1997 |
Inhibition of angiotensin II pressor response and ex vivo angiotensin II radioligand binding by candesartan cilexetil and losartan in healthy human volunteers.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Double-Blind Method; Humans; Losartan; Male; Tetrazoles | 1997 |
[Angiotensin II antagonists].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Pressure; Humans; Hypertension; Imidazoles; Losartan; Receptors, Angiotensin; Tetrazoles; Water-Electrolyte Balance | 1995 |
Effect of AT1 receptor blockade on cardiac collagen remodeling after myocardial infarction.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biomarkers; Blotting, Northern; Collagen; Hydrogen-Ion Concentration; Hydroxyproline; Immunohistochemistry; Losartan; Male; Myocardial Infarction; Myocardium; Rats; Rats, Sprague-Dawley; RNA, Messenger; Ventricular Function, Left | 1997 |
Actions of angiotensin and lisinopril on thalamic somatosensory neurons in normotensive, non-transgenic and hypertensive, transgenic rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Genetically Modified; Antihypertensive Agents; Disease Models, Animal; Electroencephalography; Hypertension; Imidazoles; Lisinopril; Losartan; Male; Neurons, Afferent; Pyridines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thalamus; Vasoconstrictor Agents | 1997 |
[New therapeutic principle in the management of cardiac insufficiency: A II antagonists. Results of the ELITE study (Evaluation of Losartan In The Elderly)].
Topics: Aged; Angiotensin II; Anti-Arrhythmia Agents; Female; Heart Failure; Humans; Losartan; Male; Renin-Angiotensin System | 1997 |
Expression of type 1 angiotensin II receptor subtypes and angiotensin II-induced calcium mobilization along the rat nephron.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium Channels; Culture Techniques; Imidazoles; Losartan; Male; Nephrons; Polymerase Chain Reaction; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger | 1997 |
Interaction of angiotensin II and TGF-beta 1 in the rat remnant kidney.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Culture Techniques; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Kidney; Kidney Glomerulus; Losartan; Male; Nephrectomy; Organ Size; Rats; Rats, Sprague-Dawley; Reference Values; RNA; Transforming Growth Factor beta | 1997 |
Role of brain angiotensin in thirst and sodium appetite of rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Appetite; Brain; Drinking; Eating; Furosemide; Imidazoles; Injections, Intraventricular; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Sodium; Sodium, Dietary; Thirst | 1997 |
Effect of luminal angiotensin II on rabbit proximal convoluted tubule bicarbonate absorption.
Topics: Absorption; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Bicarbonates; Biological Transport; Enalaprilat; Female; Imidazoles; Kidney Tubules, Proximal; Losartan; Pyridines; Rabbits | 1997 |
Losartan-associated atypical cutaneous lymphoid hyperplasia.
Topics: Aged; Angiotensin II; Drug Hypersensitivity; Humans; Losartan; Male; Pseudolymphoma; Skin Diseases | 1997 |
Use of losartan in FH patients during treatment with DSC-LDL apheresis.
Topics: Angiotensin II; Blood Component Removal; Dextran Sulfate; Humans; Hyperlipoproteinemia Type II; Hypotension; Lipoproteins, LDL; Losartan | 1997 |
Pharmacological profile of YM358, a novel nonpeptide angiotensin AT1 receptor antagonist.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Azoles; Binding, Competitive; Biphenyl Compounds; Blood Pressure; Cattle; Decerebrate State; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle, Smooth, Vascular; Pyridines; Rabbits; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles | 1997 |
Antihypertensive activity of a nonpeptide angiotensin II receptor antagonist, YM358, in rats and dogs.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Azoles; Biphenyl Compounds; Blood Pressure; Dogs; Female; Heart Rate; Hypertension; Hypertension, Renal; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Wistar; Renin-Angiotensin System; Sodium | 1997 |
Losartan-induced hepatotoxicity.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Humans; Losartan; Male; Middle Aged | 1997 |
[Angiotensin-II-antagonism: new hope for the management of cardiac insufficiency].
Topics: Age Factors; Aged; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Dose-Response Relationship, Drug; Heart Failure; Humans; Losartan | 1997 |
Pharmacokinetic-pharmacodynamic relations of losartan and EXP3174 in a porcine animal model.
Topics: Angiotensin II; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Area Under Curve; Blood Pressure; Disease Models, Animal; Half-Life; Hypertension; Imidazoles; Infusions, Intravenous; Losartan; Receptors, Angiotensin; Swine; Tetrazoles | 1997 |
Pharmacologic profiles of KRH-594, a novel nonpeptide angiotensin II-receptor antagonist.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Binding, Competitive; Blood Pressure; Cattle; Cerebellum; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Liver; Losartan; Male; Rabbits; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles; Thiadiazoles | 1997 |
Angiotensin-(1-7) and the rat aorta: modulation by the endothelium.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Animals; Antihypertensive Agents; Aorta, Thoracic; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin | 1997 |
Inhibition of sympathetic outflow by the angiotensin II receptor antagonist, eprosartan, but not by losartan, valsartan or irbesartan: relationship to differences in prejunctional angiotensin II receptor blockade.
Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Decerebrate State; Electric Stimulation; Imidazoles; Irbesartan; Losartan; Male; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Tetrazoles; Thiophenes; Valine; Valsartan | 1997 |
Role of angiotensin II in the regulation of a novel vascular modulator, hepatocyte growth factor (HGF), in experimental hypertensive rats.
Topics: Aging; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Biphenyl Compounds; Blood Pressure; Enalapril; Gene Expression Regulation, Developmental; Heart; Hepatocyte Growth Factor; Humans; Hypertension; Imidazoles; Losartan; Lung; Male; Myocardium; Organ Specificity; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Regression Analysis | 1997 |
Role of angiotensin II receptor subtypes in mediating the sympathoexcitatory effects of exogenous and endogenous angiotensin peptides in the rostral ventrolateral medulla of the rabbit.
Topics: Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Denervation; Female; Imidazoles; Losartan; Male; Medulla Oblongata; Microinjections; Pressoreceptors; Pyridines; Rabbits; Receptors, Angiotensin; Sympathetic Nervous System | 1997 |
Role of dorsal vagal motor nucleus in angiotensin II-mediated tachycardia in the conscious trout Oncorhynchus mykiss.
Topics: Angiotensin II; Animals; Blood Pressure; Female; Heart Rate; Losartan; Male; Microinjections; Motor Neurons; Oncorhynchus mykiss; Vagus Nerve | 1997 |
Angiotensin II stimulates proliferation of normal early erythroid progenitors.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Cell Differentiation; Cells, Cultured; Erythroid Precursor Cells; Erythropoiesis; Erythropoietin; Gene Expression; Gene Expression Regulation, Developmental; Humans; Losartan; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Receptors, Erythropoietin; RNA, Messenger | 1997 |
Losartan influences behavioural effects of angiotensin II(3-7) in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Behavior, Animal; Learning; Losartan; Male; Peptide Fragments; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2 | 1997 |
Angiotensin-II stimulates nitric oxide release in isolated perfused renal resistance arteries.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Electric Conductivity; Endothelium, Vascular; Losartan; Male; Microelectrodes; Nitric Oxide; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renal Artery; Tetrazoles; Vascular Resistance | 1998 |
Contribution of humoral systems to the recovery of blood pressure following severe haemorrhage.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Angiotensin II; Animals; Antihypertensive Agents; Arginine Vasopressin; Blood Pressure; Catecholamines; Diastole; Heart Rate; Hemodynamics; Hemorrhage; Hormone Antagonists; Losartan; Male; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Renin-Angiotensin System; Systole | 1997 |
The effect of angiotensin AT1 receptor blockade in the brain on the maintenance of blood pressure during haemorrhage in sheep.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Arginine Vasopressin; Arteries; Blood Pressure; Brain; Cerebral Hemorrhage; Cerebrospinal Fluid; Dose-Response Relationship, Drug; Female; Injections, Intraventricular; Losartan; Renin; Sheep; Vasoconstrictor Agents | 1997 |
Pharmacological profiles of a novel non-peptide angiotensin II type I receptor antagonist HR720 in vitro and in vivo.
Topics: Adrenal Glands; Adult; Aged; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cricetinae; Humans; Imidazoles; In Vitro Techniques; Losartan; Male; Mesocricetus; Middle Aged; Muscle, Smooth, Vascular; Rabbits; Rats; Tetrazoles; Thermodynamics | 1997 |
Losartan-mediated regulation of phospholipid biosynthesis.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cell Line; Choline; Dose-Response Relationship, Drug; Losartan; Myocardium; Phosphatidylcholines; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 1997 |
Losartan and renal transplantation.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Erythrocyte Count; Erythropoiesis; Humans; Hypertension; Kidney Transplantation; Losartan; Male; Postoperative Complications | 1998 |
The effects of angiotensin II and specific angiotensin receptor blockers on embryonic cardiac development and looping patterns.
Topics: Actins; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cardiomegaly; Fetal Heart; Fibroblasts; Heart Ventricles; Hypertrophy; Imidazoles; Losartan; Morphogenesis; Myocardium; Myosin Heavy Chains; Organ Culture Techniques; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 1997 |
AT2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism.
Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Cerebrovascular Disorders; Cyclic GMP; Hypertension; Imidazoles; Losartan; Male; Minoxidil; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Pyridines; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reference Values | 1998 |
Angiotensin-(1-7) contributes to the antihypertensive effects of blockade of the renin-angiotensin system.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Bradykinin; Dipeptides; Heart Rate; Hypertension; Kinetics; Lisinopril; Losartan; Male; Neprilysin; Organophosphonates; Peptide Fragments; Peptides, Cyclic; Phenylalanine; Protease Inhibitors; Rats; Rats, Inbred SHR; Renin-Angiotensin System | 1998 |
Effects of AT1 and AT2 angiotensin receptor antagonists in angiotensin II-infused rats.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Arteries; Blood Pressure; Body Weight; Coronary Vessels; Femoral Artery; Heart; Imidazoles; Infusions, Parenteral; Kidney; Losartan; Organ Size; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 1998 |
Comparative effects of the angiotensin II receptor blocker EXP 3174 and of the angiotensin-converting enzyme inhibitor captopril on renal glomerular hemodynamics in the dog.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Flow Velocity; Blood Pressure; Bradykinin; Captopril; Dogs; Drug Combinations; Female; Glomerular Filtration Rate; Imidazoles; Kidney Glomerulus; Losartan; Male; Potassium; Sodium; Tetrazoles; Urea; Vascular Resistance; Vasodilation; Water | 1997 |
Venoconstriction by angiotensin II in the human forearm is inhibited by losartan but not by nicardipine.
Topics: Adult; Angiotensin II; Antihypertensive Agents; Arteries; Forearm; Humans; Losartan; Male; Nicardipine; Regional Blood Flow; Vasoconstriction; Veins | 1998 |
Evaluation of Losartan in the Elderly (ELITE) Trial: clinical implications.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Captopril; Heart Failure; Humans; Losartan; Randomized Controlled Trials as Topic; Treatment Outcome | 1997 |
Angiotensin II stimulates the production of NO and peroxynitrite in endothelial cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Arginine; Bradykinin; Calcium; Calmodulin; Cells, Cultured; Endothelium, Vascular; Losartan; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Oxidants; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sulfonamides | 1998 |
Responses to angiotensin peptides are mediated by AT1 receptors in the rat.
Topics: Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Female; Hindlimb; Imidazoles; Losartan; Male; Norepinephrine; Peptide Fragments; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles | 1998 |
Role of AT1 angiotensin II receptors in renal ischemic injury.
Topics: Angiotensin II; Angiotensinogen; Animals; Creatinine; Ischemia; Kidney; Kidney Cortex; Kidney Medulla; Kidney Tubules, Proximal; Losartan; Male; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reference Values; Reperfusion; RNA, Messenger; Transcription, Genetic; Up-Regulation | 1998 |
Vasodepressor actions of angiotensin-(1-7) unmasked during combined treatment with lisinopril and losartan.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antibodies, Monoclonal; Antihypertensive Agents; Blood Pressure; Heart Rate; Imidazoles; Immunoglobulin G; Lisinopril; Losartan; Male; Mice; Mice, Inbred BALB C; Peptide Fragments; Pyridines; Rats; Rats, Inbred SHR; Vasodilation | 1998 |
Sustained phospholipase D activation in response to angiotensin II but not carbachol in bovine adrenal glomerulosa cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Carbachol; Cattle; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Losartan; Phospholipase D; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Zona Glomerulosa | 1998 |
Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes.
Topics: Adrenal Glands; Anesthetics; Angiotensin II; Angiotensinogen; Animals; Benzimidazoles; beta-Galactosidase; Biphenyl Compounds; Blood Pressure; Imidazoles; Infusions, Intravenous; Kidney; Losartan; Mice; Mice, Knockout; Myocardium; Phenotype; Pyridines; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Saralasin; Staining and Labeling; Tetrazoles; Thiopental; Zygote | 1998 |
Blockade of angiotensin II receptors inhibits the increase in blood pressure induced by insulin.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine Vasopressin; Blood Glucose; Blood Pressure; Captopril; Ganglionic Blockers; Heart Rate; Hexamethonium; Hormone Antagonists; Infusions, Intravenous; Injections, Intraventricular; Insulin; Losartan; Male; Norepinephrine; Rats; Rats, Wistar; Renin-Angiotensin System; Sympathetic Nervous System; Sympathomimetics | 1998 |
Effects of an angiotensin II antagonist on ischemic and nonischemic isolated rat hearts.
Topics: Angiotensin II; Animals; Coronary Circulation; Heart; Heart Arrest, Induced; Hemodynamics; Losartan; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Oxygen Consumption; Rats; Rats, Wistar | 1998 |
Local upregulation of colonic angiotensin II receptors enhances potassium excretion in chronic renal failure.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Colon; Imidazoles; Kidney Failure, Chronic; Losartan; Male; Potassium; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Rubidium Radioisotopes; Up-Regulation | 1998 |
Angiotensin receptor antagonist improves cardiac reflex control of renal sodium handling in heart failure.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Baroreflex; Blood Pressure; Heart; Heart Failure; Kidney; Losartan; Male; Rats; Rats, Sprague-Dawley; Sodium; Sodium Chloride; Sodium, Dietary; Solutions; Sympathetic Nervous System; Vagus Nerve | 1998 |
Area postrema lesion attenuates the long-term hypotensive effects of losartan in salt-replete rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Drinking; Food Deprivation; Heart Rate; Losartan; Male; Medulla Oblongata; Rats; Rats, Sprague-Dawley; Renin; Sodium, Dietary; Water-Electrolyte Balance | 1998 |
Effects of angiotensin II on bone cells in vitro.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Binding, Competitive; Cell Division; Cells, Cultured; Collagen; DNA; Femur Head; Fetus; Humans; Imidazoles; Losartan; Osteoblasts; Osteoclasts; Parathyroid Hormone; Pyridines; Rats; Skull; Vasoconstrictor Agents | 1998 |
[Physiopathology of angiotensin II and vascular lesion].
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arteriosclerosis; Humans; Hypertension; Losartan | 1997 |
Angiotensin II activates Na+-independent Cl--HCO3- exchange in ventricular myocardium.
Topics: Alkaloids; Amiloride; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antiporters; Benzophenanthridines; Bicarbonates; Cats; Chloride-Bicarbonate Antiporters; Chlorides; Enzyme Inhibitors; Heart Ventricles; Hydrogen-Ion Concentration; In Vitro Techniques; Losartan; Myocardium; Phenanthridines; Protein Kinase C; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Signal Transduction; Sodium; Sodium-Hydrogen Exchangers | 1998 |
Angiotensin II-nitric oxide interaction on sympathetic outflow in conscious rabbits.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Consciousness; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine; Rabbits; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sympathetic Nervous System | 1998 |
Comparison of angiotensin II type-1 and type-2 receptor antagonists on angiotensin II-induced IP3 generation in cardiomyocytes.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Chick Embryo; Heart; Imidazoles; Inositol 1,4,5-Trisphosphate; Losartan; Myocardium; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2 | 1998 |
Role of AT1 and AT2 receptors in the plasma clearance of angiotensin II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Half-Life; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Inbred SHR; Receptors, Angiotensin | 1998 |
Acute sodium depletion modifies septo-preoptic neuron sensitivities to neurohormones.
Topics: Aldosterone; Angiotensin II; Angiotensins; Animals; Imidazoles; Losartan; Male; Neurons; Preoptic Area; Pyridines; Rats; Rats, Wistar; Septum Pellucidum; Sodium | 1998 |
Role of AT2 receptors in the cardiovascular events following microinjection of angiotensin II into the superior colliculus of anaesthetised rats.
Topics: Anesthesia, General; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Hemodynamics; Imidazoles; Losartan; Male; Microinjections; Microspheres; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Regional Blood Flow; Superior Colliculi | 1998 |
The in vitro pharmacological profile of KR31080, a nonpeptide AT1 receptor antagonist.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Cattle; Cerebellum; Humans; Imidazoles; In Vitro Techniques; Iodine Radioisotopes; Losartan; Membranes; Muscle Contraction; Muscle, Smooth, Vascular; Pyridines; Rabbits; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Recombinant Proteins; Tetrazoles | 1998 |
Role of angiotensin in renal sympathetic activation in nephrotic syndrome.
Topics: Angiotensin II; Animals; Baroreflex; Blood Pressure; Body Weight; Heart Rate; Infusions, Intravenous; Injections, Intraventricular; Kidney; Losartan; Male; Natriuresis; Nephrotic Syndrome; Pressoreceptors; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Sympathetic Nervous System | 1998 |
Upregulation of vascular endothelial growth factor by angiotensin II in rat heart endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Antihypertensive Agents; Blotting, Northern; Cattle; Culture Media, Conditioned; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Imidazoles; Immunoblotting; Losartan; Lymphokines; Nucleic Acid Synthesis Inhibitors; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Rats; RNA, Messenger; Transcription Factors; Transcriptional Activation; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vasoconstrictor Agents | 1998 |
Role of nitric oxide in responses to renin-angiotensin system inhibition in sodium-depleted guinea pig and rat.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Dipeptides; Guinea Pigs; Imidazoles; Losartan; Male; Morpholines; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Sprague-Dawley; Renin; Renin-Angiotensin System; Sodium; Tetrazoles | 1998 |
Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Apoptosis; Arginine; Biotin; Cyclosporine; Deoxyuracil Nucleotides; DNA Fragmentation; Enzyme Inhibitors; Fibrosis; Hydralazine; Immunosuppressive Agents; Ischemia; Kidney; Losartan; Macrophages; Male; Nephritis, Interstitial; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Staining and Labeling | 1998 |
Distribution and functional significance of angiotensin-II AT1- and AT2-receptor subtypes in the rat adrenal gland.
Topics: Adrenal Glands; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Autoradiography; Catecholamines; Imidazoles; Iodine Radioisotopes; Losartan; Male; Oligopeptides; Osmolar Concentration; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 1998 |
The AT2 receptor-mediated stimulation of adrenal catecholamine release may potentiate the AT1 receptor-mediated aldosterone secretagogue action of angiotensin-II in rats.
Topics: Adrenal Glands; Aldosterone; Alprenolol; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Catecholamines; Cells, Cultured; Chromaffin Cells; Culture Techniques; Dose-Response Relationship, Drug; Imidazoles; Losartan; Male; Osmolar Concentration; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Zona Glomerulosa | 1998 |
High-protein diets augment albuminuria in rats with Heymann nephritis by angiotensin II-dependent and -independent mechanisms.
Topics: Albuminuria; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Dietary Proteins; Enalapril; Glomerular Filtration Rate; Glomerulonephritis; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin | 1998 |
[Activation of the cardiac angiotensin-converting enzyme after myocardial infarction and its role in ventricular remodeling].
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Captopril; Heart; Heart Ventricles; Hemodynamics; Hydroxyproline; Losartan; Male; Myocardial Infarction; Peptidyl-Dipeptidase A; Proteins; Rats; Rats, Inbred Strains; Rats, Wistar; Vasoconstrictor Agents | 1997 |
Action of AT1 subtype angiotensin II receptors of the medial preoptic area on gonadotropins and prolactin release.
Topics: Angiotensin II; Animals; Estradiol; Female; Follicle Stimulating Hormone; Kinetics; Losartan; Luteinizing Hormone; Microinjections; Ovariectomy; Preoptic Area; Prolactin; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 1998 |
Hemodynamic effect of 17 beta-estradiol in absence of NO in ovariectomized rats: role of angiotensin II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cardiac Output; Enzyme Inhibitors; Estradiol; Female; Hemodynamics; Losartan; NG-Nitroarginine Methyl Ester; Nitric Oxide; Ovariectomy; Rats; Rats, Sprague-Dawley; Vascular Resistance | 1998 |
Role of AT1 receptors in the renal papillary effects of acute and chronic nitric oxide inhibition.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Enzyme Inhibitors; Kidney Medulla; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Regional Blood Flow | 1998 |
Autocrine/paracrine determinants of strain-activated brain natriuretic peptide gene expression in cultured cardiac myocytes.
Topics: Angiotensin II; Animals; Antibodies; Autocrine Communication; Cells, Cultured; Culture Media, Conditioned; Endothelin-1; Gene Expression Regulation; Genes, Reporter; Humans; Losartan; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Paracrine Communication; Peptides, Cyclic; Promoter Regions, Genetic; Rats; RNA, Messenger; Sprains and Strains; Transfection; Transforming Growth Factor beta; Ventricular Function | 1998 |
PDGF-BB-induced DNA synthesis is delayed by angiotensin II in vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anticoagulants; Antihypertensive Agents; Becaplermin; Cells, Cultured; DNA Replication; Drug Interactions; Losartan; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Vasoconstrictor Agents | 1998 |
Relationship between the increase in Ca2+ transient and contractile force induced by angiotensin II in aequorin-loaded rabbit ventricular myocardium.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aequorin; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Bupranolol; Calcium; Electric Stimulation; Imidazoles; In Vitro Techniques; Losartan; Male; Microinjections; Myocardial Contraction; Myocardium; Prazosin; Pyridines; Rabbits; Stimulation, Chemical | 1998 |
Effects of angiotensin II on endothelial cell growth: role of AT-1 and AT-2 receptors.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium; Cattle; Cell Count; Cell Division; Cell Line; DNA; Dose-Response Relationship, Drug; Endothelium, Vascular; Imidazoles; Losartan; Pyridines; Receptors, Angiotensin | 1998 |
Losartan but not verapamil inhibits angiotensin II-induced tissue endothelin-1 increase: role of blood pressure and endothelial function.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Calcium Channel Blockers; Data Interpretation, Statistical; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Hypertension; In Vitro Techniques; Losartan; Male; Muscle, Smooth, Vascular; Nitroprusside; Rats; Rats, Inbred WKY; Receptors, Endothelin; Time Factors; Vasoconstriction; Vasodilation; Vasodilator Agents; Verapamil | 1998 |
The receptor subtype mediating the action of angiotensin II on intracellular sodium in rat proximal tubules.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Extracellular Space; Imidazoles; In Vitro Techniques; Ion Transport; Kidney Tubules, Proximal; Losartan; Male; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Sodium | 1998 |
Renal uptake of circulating angiotensin II in Val5-angiotensin II infused rats is mediated by AT1 receptor.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Kidney; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin | 1998 |
Renal vascular responses to angiotensin II in conscious spontaneously hypertensive and normotensive rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Kidney Cortex; Losartan; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Regional Blood Flow; Vascular Resistance | 1998 |
Growth response of human coronary smooth muscle cells to angiotensin II and influence of angiotensin AT1 receptor blockade.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Calcium; Cell Division; Cells, Cultured; Coronary Vessels; DNA; Humans; Imidazoles; Immunohistochemistry; Losartan; Muscle, Smooth, Vascular; Polymerase Chain Reaction; Protein Biosynthesis; Pyridines; Receptors, Angiotensin; Vasoconstrictor Agents | 1998 |
Characterization and distribution of angiotensin II receptor subtypes in the mouse brain.
Topics: Angiotensin II; Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Caudate Nucleus; Imidazoles; In Vitro Techniques; Kinetics; Ligands; Locus Coeruleus; Losartan; Male; Mice; Mice, Inbred C57BL; Oligopeptides; Pyridines; Rats; Receptors, Angiotensin | 1998 |
Functional interactions of L-162,313 with angiotensin II receptor subtypes and mutants.
Topics: Angiotensin II; Animals; Binding Sites; Binding, Competitive; Biphenyl Compounds; Cells, Cultured; COS Cells; Haplorhini; Imidazoles; Inositol Phosphates; Kidney; Losartan; Point Mutation; Rats; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Vasoconstrictor Agents | 1998 |
Evidence that angiotensin II, endothelins and nitric oxide regulate mitogen-activated protein kinase activity in rat aorta.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Peptides, Cyclic; Rats; Rats, Wistar | 1998 |
Angiotensin AT1 receptor-mediated excitation of rat carotid body chemoreceptor afferent activity.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Carotid Body; Electric Stimulation; Electrophysiology; Imidazoles; Iodine Radioisotopes; Ligands; Losartan; Male; Membrane Potentials; Neurons, Afferent; Patch-Clamp Techniques; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 1998 |
Effects of the AT1 antagonist HR 720 in comparison to losartan on stimulated sympathetic outflow, blood pressure, and heart rate in pithed spontaneously hypertensive rats.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Catecholamines; Decerebrate State; Dose-Response Relationship, Drug; Electric Stimulation; Heart Rate; Hemodynamics; Hypertension; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Sympathetic Nervous System | 1998 |
Angiotensin II and endothelin-1 receptor antagonists have cumulative hypotensive effects in canine Page hypertension.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Bosentan; Disease Models, Animal; Dogs; Endothelin Receptor Antagonists; Endothelin-1; Hypertension, Renovascular; Infusions, Intravenous; Losartan; Radioimmunoassay; Receptor, Endothelin A; Sulfonamides; Vascular Resistance | 1998 |
[7-D-ALA]-angiotensin 1-7 blocks renal actions of angiotensin 1-7 in the anesthetized rat.
Topics: Anesthesia; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Kidney; Kidney Function Tests; Kidney Tubules, Proximal; Losartan; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Renal Circulation | 1998 |
Hypothalamic angiotensin receptor subtypes in normotensive and hypertensive rats.
Topics: Angiotensin II; Animals; Binding, Competitive; Hypertension; Hypothalamus; Imidazoles; Kinetics; Losartan; Male; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reference Values; Species Specificity | 1998 |
Peripheral vascular tone in patients with cirrhosis: role of the renin-angiotensin and sympathetic nervous systems.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Female; Forearm; Humans; Liver Cirrhosis; Losartan; Male; Middle Aged; Nitric Oxide Synthase; Norepinephrine; omega-N-Methylarginine; Plethysmography; Regional Blood Flow; Renin-Angiotensin System; Sympathetic Nervous System; Sympathomimetics; Vascular Resistance | 1998 |
Thrombin receptor expression is increased by angiotensin II in cultured and native vascular smooth muscle cells.
Topics: 6-Ketoprostaglandin F1 alpha; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Blotting, Northern; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Indoles; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Polymerase Chain Reaction; Protein Kinase C; Rats; Rats, Wistar; Receptors, Thrombin; RNA, Messenger; Tetrazoles; Thrombin | 1998 |
Characterization of angiotensin II receptors (binding and mRNA) in the rat thyroid gland.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding Sites; DNA Primers; Imidazoles; Kinetics; Losartan; Male; Polymerase Chain Reaction; Pyridines; Rabbits; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Thyroid Gland | 1998 |
Regulation of jejunal sodium and water absorption by angiotensin subtype receptors.
Topics: Adrenergic alpha-1 Receptor Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cyclic AMP; Cyclic GMP; Diet, Sodium-Restricted; Dinoprostone; Dose-Response Relationship, Drug; Guanethidine; Homeostasis; Imidazoles; Intestinal Absorption; Intestinal Mucosa; Jejunum; Kinetics; Losartan; Male; Mesenteric Arteries; Oligopeptides; Prazosin; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Time Factors; Water | 1998 |
Central losartan blocks natriuretic, vasopressin, and pressor responses to central hypertonic NaCl in sheep.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine Vasopressin; Blood Pressure; Carbachol; Cerebral Ventricles; Female; Infusions, Intravenous; Infusions, Parenteral; Kidney; Losartan; Natriuresis; Potassium; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Saline Solution, Hypertonic; Sheep; Sodium; Time Factors | 1998 |
ANG II AT1 receptors induce depolarization and inward current in rat median preoptic neurons in vitro.
Topics: Action Potentials; Angiotensin II; Animals; Fluorescent Dyes; Imidazoles; In Vitro Techniques; Isoquinolines; Losartan; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Preoptic Area; Pyridines; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrodotoxin | 1998 |
Angiotensin II induces acrosomal exocytosis in bovine spermatozoa.
Topics: Acrosin; Acrosome; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Calcimycin; Cattle; Exocytosis; Female; Humans; Imidazoles; Losartan; Male; Pyridines; Receptors, Angiotensin; Sperm Capacitation; Sperm-Ovum Interactions | 1998 |
Endogenous ANG II supports lumbar sympathetic activity in conscious sodium-deprived rats: role of area postrema.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Baroreflex; Blood Pressure; Cerebral Ventricles; Consciousness; Diet, Sodium-Restricted; Food Deprivation; Heart Rate; Hemodynamics; Losartan; Lumbosacral Region; Male; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System | 1998 |
Role of ANG II in mediating somatosensory-induced renal nerve-dependent antinatriuresis in the rat.
Topics: Analysis of Variance; Angiotensin II; Animals; Blood Pressure; Capsaicin; Cerebral Ventricles; Denervation; Diuresis; Glomerular Filtration Rate; Hemodynamics; Injections, Intraventricular; Kidney; Losartan; Male; Mechanoreceptors; Natriuresis; Rats; Rats, Wistar; Renal Circulation; Skin; Sympathetic Nervous System | 1998 |
Endogenous angiotensin II modulates rat proximal tubule transport with acute changes in extracellular volume.
Topics: Absorption; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biological Transport; Blood Pressure; Diuresis; Extracellular Space; Kidney Tubules, Proximal; Losartan; Male; Rats; Rats, Sprague-Dawley; Sodium; Ultrafiltration | 1998 |
Effects of losartan on the treatment of posttransplant erythrocytosis.
Topics: Adult; Angiotensin II; Humans; Kidney Transplantation; Losartan; Male; Polycythemia | 1998 |
A novel angiotensin II binding site in murine tissues.
Topics: Amino Acid Sequence; Angiotensin II; Animals; Autoradiography; Binding Sites; Humans; Imidazoles; Losartan; Mice; Mice, Inbred C57BL; Mice, Nude; Pyridines; Saralasin; Tumor Cells, Cultured | 1998 |
Differential action of angiotensin II and activity of angiotensin-converting enzyme in human bypass grafts.
Topics: Adult; Aged; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Captopril; Coronary Artery Bypass; Female; Graft Occlusion, Vascular; Humans; Imidazoles; In Vitro Techniques; Losartan; Male; Middle Aged; Nitric Oxide Synthase; Peptidyl-Dipeptidase A; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Saphenous Vein; Thoracic Arteries; Vasoconstriction; Vasoconstrictor Agents | 1998 |
Losartan inhibits thromboxane A2-induced platelet aggregation and vascular constriction in spontaneously hypertensive rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Angiotensin II; Animals; Antihypertensive Agents; Aorta; Endothelins; Endothelium, Vascular; Imidazoles; Losartan; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Inbred SHR; Receptors, Prostaglandin; Receptors, Thromboxane A2, Prostaglandin H2; Tetrazoles; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents | 1998 |
Further evidence for interaction between angiotensin II and dopamine receptors (experiments on apomorphine stereotypy).
Topics: Angiotensin II; Animals; Apomorphine; Losartan; Male; Rats; Rats, Wistar; Receptors, Dopamine; Stereotyped Behavior | 1998 |
Pouch tissue and angiotensin peptide generation.
Topics: Angiotensin I; Angiotensin II; Angiotensinogen; Angiotensins; Animals; Aspartic Acid Endopeptidases; Cathepsin D; Collagen; Gene Expression; Imidazoles; Lisinopril; Losartan; Myocardium; Peptide Biosynthesis; Peptides; Peptidyl-Dipeptidase A; Pyridines; Rats; Renin; Transforming Growth Factor beta | 1998 |
Arginine vasopressin and oxytocin responses to angiotensin II are mediated by AT1 receptor subtype in normal men.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Arginine Vasopressin; Drug Administration Schedule; Humans; Infusions, Intravenous; Losartan; Male; Oxytocin; Reference Values | 1998 |
Angiotensin II receptor antagonists: what future?
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Enalapril; Humans; Hypertension; Losartan | 1998 |
Effects of losartan and captopril on endothelin-1 production in blood vessels and glomeruli of rats with reduced renal mass.
Topics: Angiotensin II; Animals; Blood Pressure; Blood Vessels; Captopril; Endothelin-1; Kidney Failure, Chronic; Kidney Glomerulus; Losartan; Male; Nephrectomy; Rats; Rats, Sprague-Dawley | 1998 |
Losartan antagonism of angiotensin-II-induced potassium secretion across rat colon.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biological Transport; Colon; Dose-Response Relationship, Drug; Drug Antagonism; Extracellular Space; Hydrolysis; Imidazoles; In Vitro Techniques; Losartan; Male; Potassium; Pyridines; Rats; Rats, Sprague-Dawley; Rubidium Radioisotopes; Tetrazoles | 1998 |
Extending the targets for antihypertensive drugs.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Endothelin-1; Enzyme Inhibitors; Humans; Losartan; Neprilysin; Renin; Renin-Angiotensin System; Vasopressins | 1998 |
Evaluation of the ability of irbesartan to cross the blood-brain barrier following acute intragastric treatment.
Topics: Adrenalectomy; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood-Brain Barrier; Carbachol; Drug Evaluation; Injections, Intraventricular; Irbesartan; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Wistar; Stomach; Tetrazoles | 1998 |
Microvasculature in angiotensin II-dependent cardiac hypertrophy in the rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Arterioles; Capillaries; Hypertension; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Vasoconstrictor Agents | 1998 |
Different receptors for angiotensin II at pre- and postjunctional level of the canine mesenteric and pulmonary arteries.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Dogs; Female; Imidazoles; Losartan; Male; Mesenteric Arteries; Neuroeffector Junction; Pulmonary Artery; Pyridines; Receptors, Angiotensin; Saralasin | 1998 |
Mechanisms of spontaneous baroreflex impairment in lyon hypertensive rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Heart Rate; Hypertension; Indoles; Losartan; Male; Perindopril; Rats | 1998 |
Salt appetite: interaction of forebrain angiotensinergic and hindbrain serotonergic mechanisms.
Topics: Angiotensin II; Animals; Appetite; Captopril; Catheterization; Furosemide; Injections, Intraventricular; Injections, Subcutaneous; Losartan; Male; Methysergide; Prosencephalon; Rats; Rats, Sprague-Dawley; Rhombencephalon; Serotonin; Sodium Chloride; Subfornical Organ | 1998 |
Vascular and excretory effects of angiotensin II in the rat isolated perfused kidney: influence of an AT1 and a nonselective AT receptor antagonist.
Topics: 6-Ketoprostaglandin F1 alpha; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Dinoprostone; Female; Glomerular Filtration Rate; In Vitro Techniques; Kidney; Losartan; Male; Perfusion; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sodium; Urine; Vascular Resistance; Vasoconstrictor Agents | 1998 |
Critical role of AT1 receptor expression after ischemia/reperfusion in isolated rat hearts: beneficial effect of antisense oligodeoxynucleotides directed at AT1 receptor mRNA.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; In Vitro Techniques; Losartan; Male; Myocardial Reperfusion Injury; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger | 1998 |
Angiotensin-dependent gene expression in the developing rat kidney.
Topics: Amino Acid Sequence; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Antihypertensive Agents; Blotting, Northern; Endothelial Growth Factors; Epidermal Growth Factor; Gene Expression Regulation, Developmental; Growth Substances; Kidney; Losartan; Lymphokines; Molecular Sequence Data; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; RNA, Messenger; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Angiotensin II, transforming growth factor-beta1 and repair in the infarcted heart.
Topics: Angiotensin II; Animals; Collagen; Fibrosis; Losartan; Male; Myocardial Infarction; Myocardium; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; RNA, Messenger; Transforming Growth Factor beta | 1998 |
Angiotensin II type 1 receptor: relationship with caveolae and caveolin after initial agonist stimulation.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Caveolin 1; Caveolins; Cells, Cultured; Dogs; Drug Interactions; Ionomycin; Ionophores; Losartan; Membrane Proteins; Muscle, Smooth, Vascular; Precipitin Tests; Rats; Receptors, Angiotensin; RNA, Messenger; Signal Transduction; Vasoconstrictor Agents | 1998 |
Insulin-mediated growth in aortic smooth muscle and the vascular renin-angiotensin system.
Topics: Angiotensin II; Angiotensinogen; Animals; Antihypertensive Agents; Aorta; Captopril; Cell Division; Cells, Cultured; Insulin; Losartan; Male; Muscle Development; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Renin-Angiotensin System; Serine Proteinase Inhibitors; Thymidine; Vasoconstrictor Agents | 1998 |
Converting enzyme determines plasma clearance of angiotensin-(1-7).
Topics: Administration, Oral; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Genetically Modified; Blood Pressure; Chromatography, High Pressure Liquid; Drug Combinations; Half-Life; Lisinopril; Losartan; Male; Metabolic Clearance Rate; Peptide Fragments; Radioimmunoassay; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Species Specificity | 1998 |
Effects of angiotensin II and losartan in the forearm of patients with essential hypertension.
Topics: Adult; Angiotensin II; Antihypertensive Agents; Enzyme Inhibitors; Female; Forearm; Humans; Hypertension; Losartan; Male; Methoxamine; Middle Aged; omega-N-Methylarginine; Regional Blood Flow; Vasoconstrictor Agents | 1998 |
Angiotensin II blockade followed by growth hormone as adjunctive therapy after experimental myocardial infarction.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Body Weight; Diastole; Drug Therapy, Combination; Echocardiography; Female; Growth Hormone; Hemodynamics; Hypertrophy, Left Ventricular; Kidney; Liver; Losartan; Myocardial Infarction; Myocardium; Organ Size; Random Allocation; Rats; Rats, Sprague-Dawley; Spleen; Ventricular Function, Left; Ventricular Remodeling | 1998 |
Role of central catecholaminergic pathways in the actions of endogenous ANG II on sympathetic reflexes.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Ascorbic Acid; Baroreflex; Blood Pressure; Brain; Enalaprilat; Female; Heart Rate; Hypoxia; Kidney; Losartan; Male; Oxidopamine; Rabbits; Reference Values; Renin-Angiotensin System; Sympathetic Nervous System | 1998 |
AT1 receptors mediate chronic central nervous system AII hypertension in rats fed high sodium chloride diet from weaning.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Central Nervous System Diseases; Chronic Disease; Diet, Sodium-Restricted; Hypertension; Injections, Intraventricular; Losartan; Natriuresis; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Weaning | 1998 |
Angiotensin II receptor antagonists for heart failure.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Bradykinin; Captopril; Clinical Trials as Topic; Heart Failure; Humans; Losartan; Receptors, Angiotensin | 1998 |
[Value of angiotensin II-antagonists].
Topics: Angiotensin II; Anti-Arrhythmia Agents; Antihypertensive Agents; Heart Failure; Humans; Losartan; Renin-Angiotensin System; Vasodilator Agents | 1998 |
Comparison of the effects of ACE inhibition with those of angiotensin II receptor antagonism on systolic and diastolic myocardial stunning in isolated rabbit heart.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Diastole; Enalaprilat; In Vitro Techniques; Losartan; Myocardial Contraction; Myocardial Stunning; Rabbits; Systole | 1998 |
Stretch-induced alkalinization of feline papillary muscle: an autocrine-paracrine system.
Topics: Alkalies; Alkaloids; Amiloride; Angiotensin II; Animals; Anti-Arrhythmia Agents; Autocrine Communication; Benzophenanthridines; Cats; Endothelin Receptor Antagonists; Endothelins; Enzyme Inhibitors; Heart; Hydrogen-Ion Concentration; Losartan; Muscle Contraction; Muscle Fibers, Skeletal; Oligopeptides; Papillary Muscles; Paracrine Communication; Peptides, Cyclic; Phenanthridines; Protein Kinase C; Sodium-Hydrogen Exchangers | 1998 |
Calcium- and protein kinase C-dependent activation of the tyrosine kinase PYK2 by angiotensin II in vascular smooth muscle.
Topics: Actins; Angiotensin II; Animals; Anti-Arrhythmia Agents; Aorta; Calcium; Cell Adhesion Molecules; Cells, Cultured; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Imidazoles; Losartan; Male; Muscle, Smooth, Vascular; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptor, Insulin; Receptors, Angiotensin; src-Family Kinases; Tyrosine | 1998 |
Losartan attenuates modest but not strong renal vasoconstriction induced by nitric oxide inhibition.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Enzyme Inhibitors; Hemodynamics; Homeostasis; Kidney; Losartan; Male; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Sprague-Dawley; Renal Circulation; Vasoconstriction | 1998 |
Inhibition of angiotensin II-induced contraction by losartan in human coronary arteries.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Coronary Vessels; Dose-Response Relationship, Drug; Humans; Losartan; Muscle Contraction; Muscle, Smooth, Vascular; Vasoconstrictor Agents | 1998 |
Evidence that brain angiotensin II is involved in both thirst and sodium appetite in baboons.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Appetite; Brain; Captopril; Drinking; Injections, Intraventricular; Losartan; Male; Naphthyridines; Papio; Receptors, Angiotensin; Sodium, Dietary | 1998 |
Contrasting renal effects of chronic administrations of enalapril and losartan on one-kidney, one clip hypertensive rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Diet, Sodium-Restricted; Enalapril; Glomerular Filtration Rate; Hypertension, Renovascular; Kidney; Kinins; Losartan; Male; Rats; Rats, Sprague-Dawley; Renal Circulation; Sodium | 1998 |
Mechanism of hyperthyroidism-induced renal hypertrophy in rats.
Topics: Analysis of Variance; Angiotensin II; Animals; Antihypertensive Agents; Gene Expression; Hyperthyroidism; Hypertrophy; Kidney; Losartan; Male; Nicardipine; Rats; Rats, Sprague-Dawley; Renin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thyroxine | 1998 |
Angiotensin II potentiates DNA synthesis in AT-1 transformed cardiomyocytes.
Topics: Angiotensin II; Animals; Antigens, Polyomavirus Transforming; Cell Cycle; Cell Division; Cell Line, Transformed; Cyclin B; Cyclin B1; Cyclins; DNA Replication; Gene Expression Regulation; Imidazoles; Losartan; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Myocardium; Phosphorylation; Protamine Kinase; Pyridines; Simian virus 40; Thymidine; Tumor Cells, Cultured | 1998 |
Effect of endogenous angiotensin II on renal nerve activity and its cardiac baroreflex regulation.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Diet, Sodium-Restricted; Heart; Heart Rate; Injections, Intraventricular; Kidney; Losartan; Male; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System | 1998 |
Angiotensin II delivery and binding at the microvascular endothelium and cardiac myocyte surfaces in perfused rat hearts.
Topics: Angiotensin II; Animals; Endothelium, Vascular; In Vitro Techniques; Losartan; Male; Models, Biological; Myocardium; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents | 1998 |
Increased pressor function of central vasopressinergic system in hypertensive renin transgenic rats.
Topics: Angiotensin II; Animals; Animals, Genetically Modified; Antihypertensive Agents; Arginine Vasopressin; Blood Pressure; Cerebral Ventricles; Cerebrospinal Fluid; Hormone Antagonists; Hypertension; Losartan; Male; Rats; Rats, Sprague-Dawley; Renin; Vasopressins | 1998 |
[Effects of angiotensin II receptors antagonist losartan on metabolism and morphofunctional condition myocardium in hypertensive patients].
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Echocardiography; Follow-Up Studies; Heart Ventricles; Humans; Hypertension; Losartan; Male; Middle Aged; Myocardial Contraction; Myocardium; Renin | 1998 |
Modulation of the vascular smooth muscle angiotensin subtype 2 (AT2) receptor by angiotensin II.
Topics: Angiotensin II; Animals; Antibody Specificity; Cells, Cultured; COS Cells; DNA, Complementary; Glycosylation; Imidazoles; Losartan; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Pyridines; Rabbits; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Swine; Transfection | 1998 |
Interactions between the renin-angiotensin system (RAS) and the sympathetic system.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Dose-Response Relationship, Drug; Imidazoles; Losartan; Male; Norepinephrine; Presynaptic Terminals; Rats; Rats, Inbred SHR; Receptors, Angiotensin; Renin-Angiotensin System; Sympathetic Nervous System; Tetrazoles; Vasoconstrictor Agents | 1998 |
Factors involved in the effects of losartan on endothelial dysfunction induced by aging in SHR.
Topics: Acetylcholine; Aging; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Kidney; Losartan; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitrites; Phenylephrine; Potassium Chloride; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Vasoconstrictor Agents; Vasodilation | 1998 |
Targeting TGF-beta overexpression in renal disease: maximizing the antifibrotic action of angiotensin II blockade.
Topics: Angiotensin II; Animals; Blood Pressure; Body Weight; Eating; Enalapril; Fibronectins; Fibrosis; Glomerulonephritis, Membranoproliferative; Kidney; Losartan; Male; Plasminogen Activator Inhibitor 1; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta | 1998 |
Differential effects of angiotensin II on cardiac cell proliferation and intramyocardial perivascular fibrosis in vivo.
Topics: Aldosterone; Angiotensin II; Animals; Arterioles; Blood Pressure; Cell Division; Collagen; Coronary Vessels; Endothelium, Vascular; Fibrosis; Losartan; Male; Myocardium; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin | 1998 |
Central lead administration induces natriuretic and kaliuretic effects in rats.
Topics: Angiotensin II; Animals; Anti-Arrhythmia Agents; Calcium; Gadolinium; Injections, Intraventricular; Lead; Losartan; Male; Microinjections; Natriuresis; Nervous System Diseases; Potassium; Rats; Rats, Wistar; Urine | 1998 |
Intracellular angiotensin II regulates the inward calcium current in cardiac myocytes.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium; Cricetinae; Cytosol; Dose-Response Relationship, Drug; Heart Ventricles; Losartan; Mesocricetus; Microinjections; Myocardium; Protein Kinase C; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Species Specificity; Time Factors | 1998 |
Angiotensin II receptors on colorectal carcinoma cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Cell Line, Tumor; Cell Membrane; Colorectal Neoplasms; Humans; Iodine Radioisotopes; Losartan; Oligopeptides; Receptor, Angiotensin, Type 2 | 1998 |
Dissociation of blood pressure reduction from end-organ damage in TGR(mREN2)27 transgenic hypertensive rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Genetically Modified; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Carbazoles; Carvedilol; Heart Function Tests; Hydralazine; Hypertension; Isoquinolines; Losartan; Norepinephrine; Propanolamines; Quinapril; Rats; Rats, Sprague-Dawley; Renin; RNA, Messenger; Tetrahydroisoquinolines | 1998 |
Role of angiotensin II in hyperinsulinemia-induced hypertension in rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Chronic Disease; Fosinopril; Hyperinsulinism; Hypertension; Insulin; Kidney; Losartan; Male; Rats; Rats, Sprague-Dawley | 1998 |
Endogenous angiotensin II and bradykinin delay and attenuate the hypotension after N-type calcium channel blockade in conscious rabbits.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Bradykinin; Calcium Channel Blockers; Dose-Response Relationship, Drug; Enalaprilat; Heart Rate; Hypotension; Losartan; Nasopharynx; omega-Conotoxin GVIA; Peptides; Pressoreceptors; Propranolol; Rabbits; Renin-Angiotensin System | 1998 |
Guinea pig airway hyperresponsiveness induced by blockade of the angiotensin II type 1 receptor. Role for endogenous nitric oxide.
Topics: Acetylcholine; Airway Obstruction; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Bronchi; Bronchial Hyperreactivity; Bronchoconstriction; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; Guinea Pigs; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pyridines | 1999 |
Involvement of angiotensin II in development of spontaneous nephrosis in Dahl salt-sensitive rats.
Topics: Aging; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Body Weight; Calcium Channel Blockers; Cholesterol; Glucocorticoids; Hypertension; Imidazoles; Imidazolidines; Losartan; Male; Methylprednisolone; Nephrosis; Proteinuria; Rats; Rats, Inbred Dahl; Sodium Chloride, Dietary; Verapamil | 1998 |
Angiotensin AT1 receptors in Clone 9 rat liver cells: Ca2+ signaling and c-fos expression.
Topics: Angiotensin II; Animals; Anti-Arrhythmia Agents; Calcium; Cell Line; Cells, Cultured; Clone Cells; Drug Interactions; Gene Expression; Inositol Phosphates; Liver; Losartan; Pertussis Toxin; Proto-Oncogene Proteins c-fos; Rats; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger; Signal Transduction; Virulence Factors, Bordetella | 1998 |
Effect of selective angiotensin antagonists on the antidiuresis produced by angiotensin-(1-7) in water-loaded rats.
Topics: Analysis of Variance; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Diuresis; Drinking; Kidney; Losartan; Male; Peptide Fragments; Rats; Rats, Wistar; Receptors, Angiotensin; Renal Agents | 1998 |
The hyperglycemia induced by angiotensin II in rats is mediated by AT1 receptors.
Topics: Angiotensin I; Angiotensin II; Angiotensins; Animals; Antihypertensive Agents; Hyperglycemia; Losartan; Male; Rats; Rats, Wistar; Receptors, Angiotensin; Vasoconstrictor Agents | 1998 |
Modulation of AT1 receptor-mediated contraction of rat uterine artery by AT2 receptors.
Topics: Angiotensin II; Animals; Arteries; Female; Imidazoles; Losartan; Oligopeptides; Phenylephrine; Pregnancy; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Uterus; Vasoconstriction | 1998 |
Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth.
Topics: Angiotensin II; Animals; Blood Vessels; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Culture Media; DNA; Female; Flavonoids; Gene Expression Regulation, Developmental; Imidazoles; Losartan; Mice; Mice, Knockout; Muscle Development; Muscle, Smooth, Vascular; Okadaic Acid; Phosphoproteins; Phosphorylation; Protein Binding; Pyridines; Receptors, Angiotensin; Vanadates | 1999 |
Role of the angiotensin II AT2-subtype receptors in the blood pressure-lowering effect of losartan in salt-restricted rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Diet, Sodium-Restricted; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin-Angiotensin System | 1998 |
AT1 receptors mediate angiotensin II uptake and transport by bovine brain microvessel endothelial cells in primary culture.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Biological Transport; Blood-Brain Barrier; Brain; Capillaries; Cattle; Cell Membrane Permeability; Cells, Cultured; Endothelium, Vascular; Imidazoles; Losartan; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 1999 |
AT1 receptor inhibition blunts angiotensin II-stimulated nitric oxide release in renal arteries.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Endothelium, Vascular; In Vitro Techniques; Losartan; Male; Microelectrodes; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renal Artery; Tetrazoles; Vasoconstriction | 1999 |
Histaminergic activation of endogenous angiotensin II fails to inhibit alcohol intake in rats.
Topics: Alcohol Drinking; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Ethanol; Histamine; Injections, Subcutaneous; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin | 1999 |
Role of NO and angiotensin II in the early development of endothelial functions impairment and cardiac hypertrophy in deoxycorticosterone acetate-salt hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Cardiomegaly; Desoxycorticosterone; Endothelium, Vascular; Hypertension; In Vitro Techniques; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Organ Size; Rats; Rats, Sprague-Dawley; Sodium Chloride; Splanchnic Circulation | 1998 |
Losartan and angiotensin II inhibit aldosterone production in anephric rats via different actions on the intraadrenal renin-angiotensin system.
Topics: Adrenal Glands; Aldosterone; Angiotensin II; Animals; Kidney; Losartan; Male; Membranes; Mineralocorticoid Receptor Antagonists; Nephrectomy; Rats; Rats, Sprague-Dawley; Renin; Renin-Angiotensin System | 1999 |
Roles of AT1 and AT2 receptors in the hypertensive Ren-2 gene transgenic rat kidney.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Genetically Modified; Blood Pressure; Heart Rate; Hemodynamics; Homozygote; Hypertension; Imidazoles; Kidney; Kidney Tubules; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reference Values; Renal Circulation; Renin | 1999 |
Role of AT2 receptors in angiotensin II-stimulated contraction of small mesenteric arteries in young SHR.
Topics: Aging; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Hypertension; Imidazoles; In Vitro Techniques; Losartan; Mesenteric Artery, Superior; Muscle Contraction; Muscle, Smooth, Vascular; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Vasoconstriction | 1999 |
Neuroendocrine effects of dehydration in mice lacking the angiotensin AT1a receptor.
Topics: Angiotensin II; Animals; Autoradiography; Brain; Dehydration; Iodine Radioisotopes; Losartan; Male; Mice; Mice, Knockout; Paraventricular Hypothalamic Nucleus; Pituitary Gland, Anterior; Preoptic Area; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Reference Values; Vasopressins; Water Deprivation | 1999 |
Control of adrenal cell proliferation by AT1 receptors in response to angiotensin II and low-sodium diet.
Topics: Adrenal Glands; Angiotensin II; Animals; Cell Division; Diet, Sodium-Restricted; Infusion Pumps; Losartan; Male; Rats; Rats, Wistar; Receptors, Angiotensin | 1999 |
Effects of systemic hypotension on postnatal intestinal circulation: role of angiotensin.
Topics: Aging; Angiotensin II; Animals; Animals, Newborn; Hemodynamics; Hypotension; In Vitro Techniques; Intestinal Mucosa; Intestines; Losartan; Oligopeptides; Oxygen Consumption; Regional Blood Flow; Swine; Vascular Resistance; Vasoconstriction | 1999 |
Hypertrophic response to hemodynamic overload: role of load vs. renin-angiotensin system activation.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Cats; Constriction, Pathologic; Elasticity; Heart; Hemodynamics; Hypertension; Hypertrophy, Right Ventricular; Losartan; Myocardial Contraction; Myocardium; Pulmonary Artery; Renin-Angiotensin System | 1999 |
Actions of amylin on subfornical organ neurons and on drinking behavior in rats.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Amyloid; Angiotensin II; Animals; Drinking Behavior; Electrophysiology; In Vitro Techniques; Islet Amyloid Polypeptide; Losartan; Male; Neurons; Peptide Fragments; Peptides; Rats; Rats, Wistar; Receptors, Islet Amyloid Polypeptide; Receptors, Peptide; Subfornical Organ | 1999 |
The role of angiotensin II and of its receptor subtypes in the acetic acid-induced abdominal constriction test.
Topics: Acetic Acid; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Colic; Imidazoles; Losartan; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Pyridines; Receptors, Angiotensin; Saralasin | 1999 |
Influence of losartan and nicardipine on the contractile responses of human subcutaneous arteries and veins to angiotensin II.
Topics: Acetylcholine; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Arteries; Blood Vessels; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Losartan; Nicardipine; Phenylephrine; Potassium; Skin; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents; Veins | 1999 |
Regulation of sympathetic nerve activity in heart failure: a role for nitric oxide and angiotensin II.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output, Low; Cardiac Pacing, Artificial; Chronic Disease; Hemodynamics; Kidney; Losartan; Male; Myocardium; Nitric Oxide; Nitroprusside; Organ Size; Rabbits; Reference Values; Sympathetic Nervous System | 1999 |
Angiotensin II AT1-receptor blockade inhibits monocyte activation and adherence in transgenic (mRen2)27 rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Genetically Modified; Antihypertensive Agents; Blood Cell Count; Blood Pressure; Cell Adhesion; Endothelium, Vascular; Female; Heart Rate; Hematocrit; Hydralazine; Hypertension; Losartan; Male; Monocytes; Nitroblue Tetrazolium; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System | 1999 |
Characterization of angiotensin II antagonism displayed by SK-1080, a novel nonpeptide AT1-receptor antagonist.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Binding, Competitive; Blood Pressure; Decerebrate State; Diastole; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle Contraction; Pyridines; Rabbits; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Sensitivity and Specificity; Tetrazoles | 1999 |
In vivo pharmacologic profile of SK-1080, an orally active nonpeptide AT1-receptor antagonist.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Consciousness; Diastole; Diuretics; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Furosemide; Heart Rate; Hypertension; Hypertension, Renal; Losartan; Male; Pyridines; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles | 1999 |
Angiotensin II-stimulated nitric oxide release from porcine pulmonary endothelium is mediated by angiotensin IV.
Topics: Angiotensin II; Animals; Bradykinin; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Losartan; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pulmonary Artery; Reference Values; Swine; Vasoconstrictor Agents | 1999 |
Ca2+ mobilization in adult rat cardiomyocytes by angiotensin type 1 and 2 receptors.
Topics: Adenosine Triphosphate; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium; Cells, Cultured; Heart; Imidazoles; Kinetics; Losartan; Male; Myocardial Contraction; Myocardium; Potassium Chloride; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Time Factors | 1998 |
Effects of systemic treatment with irbesartan and losartan on central responses to angiotensin II in conscious, normotensive rats.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Brain; Dose-Response Relationship, Drug; Drinking; Drug Interactions; Injections, Intravenous; Injections, Intraventricular; Irbesartan; Losartan; Male; Pituitary Gland, Posterior; Rats; Rats, Wistar; Tetrazoles; Vasopressins | 1999 |
Binding of the antagonist [3H]candesartan to angiotensin II AT1 receptor-transfected [correction of tranfected] Chinese hamster ovary cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; CHO Cells; Computer Simulation; Cricetinae; Female; Humans; In Vitro Techniques; Inositol Phosphates; Ligands; Losartan; Protein Binding; Receptors, Angiotensin; Tetrazoles; Time Factors; Transfection | 1999 |
A signaling pathway for stimulation of Na+ uptake induced by angiotensin II in primary cultured rabbit renal proximal tubule cells.
Topics: Amiloride; Angiotensin II; Animals; Antihypertensive Agents; Cells, Cultured; Cyclic AMP; Diuretics; Imidazoles; Kidney Tubules, Proximal; Losartan; Male; Protein Kinase C; Pyridines; Rabbits; Receptors, Angiotensin; Signal Transduction; Sodium; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Different pathways for Ca2+ mobilization by angiotensin II and carbachol in the circular muscle of the guinea-pig ileum.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium; Calcium Channel Blockers; Carbachol; Electric Stimulation; Female; Guinea Pigs; Ileum; Imidazoles; In Vitro Techniques; Isradipine; Losartan; Male; Membrane Potentials; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Nickel; Nifedipine; Potassium Chloride; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrodotoxin; Vasoconstrictor Agents; Verapamil | 1999 |
Angiotensin II-induced calcium signalling in isolated glomeruli from fish kidney (Oncorhynchus mykiss) and effects of losartan.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Calcium; Calcium Signaling; Fluorescent Dyes; Kidney Glomerulus; Losartan; Oncorhynchus mykiss; Organic Chemicals; Receptors, Angiotensin; Spectrometry, Fluorescence; Vasoconstrictor Agents | 1999 |
Effects of BAY 10-6734 (Embusartan), a new angiotensin II type I receptor antagonist, on vascular smooth muscle cell growth.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium; Cell Division; Cells, Cultured; Cytosol; Dihydropyridines; DNA; Imidazoles; Losartan; Male; Muscle, Smooth, Vascular; Protein Biosynthesis; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Species Specificity; Tetrazoles | 1999 |
Analysis of responses to angiotensin I (3-10) and Leu3 angiotensin (3-8) in the pulmonary vascular bed of the cat.
Topics: Angiotensin I; Angiotensin II; Animals; Blood Pressure; Captopril; Cats; Dose-Response Relationship, Drug; Female; Imidazoles; Losartan; Male; Peptide Fragments; Pulmonary Artery; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 1998 |
Angiotensin II attenuates renal cortical cyclooxygenase-2 expression.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gene Expression Regulation, Enzymologic; Isoenzymes; Kidney Cortex; Losartan; Male; Mice; Mice, Knockout; Phorbol Esters; Prostaglandin-Endoperoxide Synthases; Rabbits; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin; Renin-Angiotensin System; RNA, Messenger | 1999 |
Angiotensin II activates the proinflammatory transcription factor nuclear factor-kappaB in human monocytes.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Arteriosclerosis; Binding, Competitive; Cell Separation; Consensus Sequence; Humans; Inflammation; Losartan; Lymphocytes; Monocytes; NF-kappa B; NF-kappa B p50 Subunit; Oligonucleotides; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Time Factors; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 1999 |
Bradykinin-dependent cardioprotective effects of losartan against ischemia and reperfusion in rat hearts.
Topics: Adenosine Triphosphate; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Coronary Circulation; In Vitro Techniques; Isoquinolines; Losartan; Male; Myocardial Reperfusion Injury; Myocardium; Phosphocreatine; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrahydroisoquinolines; Ventricular Function, Left; Ventricular Pressure | 1999 |
The involvement of the renin-angiotensin system in the regulation of cell proliferation in the rat endometrium.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Cell Division; DNA Replication; Enalapril; Endometrium; Estradiol; Female; Losartan; Ovariectomy; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System | 1999 |
Differential response of angiotensin peptides in the urine of hypertensive animals.
Topics: Administration, Oral; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Genetically Modified; Antihypertensive Agents; Blood Pressure; Body Weight; Drinking; Electrolytes; Hemodynamics; Hypertension; Lisinopril; Losartan; Male; Peptide Fragments; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley | 1999 |
AT1-receptor antagonists for the treatment of chronic heart failure.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Captopril; Dogs; Heart Failure; Humans; Irbesartan; Losartan; Rats; Tetrazoles | 1999 |
Modulation of constitutive nitric oxide synthase, bcl-2 and Fas expression in cultured human coronary endothelial cells exposed to anoxia-reoxygenation and angiotensin II: role of AT1 receptor activation.
Topics: Analysis of Variance; Angiotensin II; Antihypertensive Agents; Apoptosis; Cells, Cultured; Coronary Vessels; Endothelium, Vascular; fas Receptor; Humans; Losartan; Myocardial Reperfusion Injury; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-bcl-2; Receptors, Angiotensin; RNA, Messenger | 1999 |
Comparison between angiotensin receptor antagonism and converting enzyme inhibition in heart failure. Differential acute effects according to the renin-angiotensin system activation.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Dogs; Enalaprilat; Female; Heart Failure; Hemodynamics; Imidazoles; Losartan; Male; Renin; Renin-Angiotensin System; Tetrazoles; Vasodilation | 1999 |
Angiotensin II exacerbates lipopolysaccharide-induced contractile depression in rabbit cardiac myocytes.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Calcium; Cells, Cultured; Chelating Agents; Cyclic GMP; Enzyme Inhibitors; Female; Heart Ventricles; Imidazoles; Indoles; Lipopolysaccharides; Losartan; Male; Mitochondria; Muscle Fibers, Skeletal; Myocardial Contraction; Nitric Oxide; omega-N-Methylarginine; Pyridines; Rabbits; Receptors, Angiotensin; Sepsis; Ventricular Function | 1999 |
Brain renin-angiotensin system and sympathetic hyperactivity in rats after myocardial infarction.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Brain; Cardiotonic Agents; Enzyme Inhibitors; Guanabenz; Heart Failure; Heart Rate; Injections, Intraventricular; Losartan; Male; Myocardial Infarction; Nitroprusside; Ouabain; Phenylephrine; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Stress, Physiological; Sympathetic Nervous System | 1999 |
Protective role of the angiotensin AT2 receptor in a renal wrap hypertension model.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Cyclic GMP; Hypertension, Renovascular; Imidazoles; Kidney; Losartan; Nitric Oxide; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Vasodilation | 1999 |
Effect of luminal angiotensin II receptor antagonists on proximal tubule transport.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Imidazoles; Ion Transport; Kidney Tubules, Proximal; Losartan; Male; Oligopeptides; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sodium | 1999 |
Losartan-induced cough after lisinopril therapy.
Topics: Aged; Angiotensin II; Antihypertensive Agents; Cough; Female; Humans; Lisinopril; Losartan; Randomized Controlled Trials as Topic | 1999 |
An effort to understand the molecular basis of hypertension through the study of conformational analysis of losartan and sarmesin using a combination of nuclear magnetic resonance spectroscopy and theoretical calculations.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Hypertension; Losartan; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Monte Carlo Method; Protein Conformation | 1999 |
Endothelin and angiotensin mediate most glomerular responses to nitric oxide inhibition.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Kidney Glomerulus; Losartan; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Renal Circulation; Sulfonamides | 1999 |
Functional evidence for subfornical organ-intrinsic conversion of angiotensin I to angiotensin II.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Dose-Response Relationship, Drug; Drinking; Electrophysiology; Losartan; Male; Rats; Rats, Wistar; Reaction Time; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Subfornical Organ | 1999 |
Acute hypoxic pulmonary vasoconstriction in conscious dogs decreases renin and is unaffected by losartan.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Bicarbonates; Blood Gas Analysis; Blood Pressure; Diet; Dogs; Female; Heart Rate; Hemodynamics; Hypoxia; Losartan; Plasma Volume; Pulmonary Circulation; Renin; Respiratory Mechanics; Vascular Resistance; Vasoconstriction | 1999 |
Mechanistic differences of various AT1-receptor blockers in isolated vessels of different origin.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Blood Proteins; Female; Humans; Imidazoles; In Vitro Techniques; Irbesartan; Kinetics; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Portal Vein; Rabbits; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles | 1999 |
Vascular angiotensin II receptor and calcium signaling in toadfish.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Blood Vessels; Calcium; Calcium Signaling; Cell Membrane; Female; Fishes; Imidazoles; Losartan; Male; Potassium; Pyridines; Receptors, Angiotensin | 1999 |
Evidence for a causal role of the renin-angiotensin system in nitrate tolerance.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Bosentan; Dose-Response Relationship, Drug; Drug Tolerance; Endothelium, Vascular; Female; Gene Expression; Losartan; Luminescent Measurements; Male; Multienzyme Complexes; NADH, NADPH Oxidoreductases; NADPH Oxidases; Nitrates; Nitric Oxide; Nitroglycerin; Peptidyl-Dipeptidase A; Rabbits; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin; Renin-Angiotensin System; RNA, Messenger; Sulfonamides; Superoxides; Vasoconstriction; Vasodilation; Vasodilator Agents | 1999 |
Transport of [3H]losartan across isolated perfused rabbit proximal tubule.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; In Vitro Techniques; Ketoglutaric Acids; Kidney Tubules, Proximal; Losartan; Male; p-Aminohippuric Acid; Perfusion; Probenecid; Rabbits; Renal Agents | 1999 |
Evidence of a possible role of altered angiotensin function in the treatment, but not etiology, of depression.
Topics: Adult; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Binding Sites; Cell Culture Techniques; Depression, Postpartum; Desipramine; Disease Models, Animal; Female; Fluoxetine; Humans; Losartan; Male; Mice; Receptors, Angiotensin; Tranylcypromine | 1999 |
A globin fragment, LVV-hemorphin-7, induces [3H]thymidine incorporation in a neuronal cell line via the AT4 receptor.
Topics: Angiotensin II; Binding, Competitive; DNA; Glioma; Hemoglobins; Hybrid Cells; Losartan; Neuroblastoma; Neurons; Peptide Fragments; Receptors, Angiotensin; Thymidine; Tritium; Tumor Cells, Cultured | 1999 |
Angiotensin II negatively modulates L-type calcium channels through a pertussis toxin-sensitive G protein in adrenal glomerulosa cells.
Topics: Aldosterone; Angiotensin II; Animals; Calcium; Calcium Channels; Calcium Channels, L-Type; Cattle; Cells, Cultured; GTP-Binding Proteins; Losartan; Patch-Clamp Techniques; Pertussis Toxin; Potassium; Virulence Factors, Bordetella; Zona Glomerulosa | 1999 |
Vascular mitogen-activated protein kinase activity is enhanced via angiotensin system in spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Endothelin-1; Endothelium, Vascular; Enzyme Activation; Hypertension; Losartan; Male; Peptides, Cyclic; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1999 |
Insurmountable angiotensin AT1 receptor antagonists: the role of tight antagonist binding.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Binding, Competitive; Biphenyl Compounds; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Imidazoles; Irbesartan; Losartan; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Recombinant Proteins; Tetrazoles | 1999 |
Chronic central infusion of ANG II potentiates cardiac sympathetic afferent reflex in dogs.
Topics: Angiotensin II; Animals; Cerebral Ventricles; Dogs; Female; Heart; Infusions, Parenteral; Kidney; Losartan; Male; Neurons, Afferent; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reflex; Sympathetic Nervous System | 1999 |
Role of angiotensin II in modulating the hemodynamic effects of nitric oxide synthesis inhibition.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Capillary Permeability; Enzyme Inhibitors; Extravasation of Diagnostic and Therapeutic Materials; Female; Hemodynamics; Laser-Doppler Flowmetry; Losartan; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley | 1999 |
Renal cellular response to ureteral obstruction: role of maturation and angiotensin II.
Topics: Age Factors; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Imidazoles; Kidney; Losartan; Pyridines; Rats; Rats, Sprague-Dawley; Ureteral Obstruction | 1999 |
Losartan-sensitive renal damage caused by chronic NOS inhibition does not involve increased renal angiotensin II concentrations.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Enzyme Inhibitors; Kidney; Losartan; Male; Nitric Oxide Synthase; Nitroarginine; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Time Factors | 1999 |
Mechanical stretch and angiotensin II differentially upregulate the renin-angiotensin system in cardiac myocytes In vitro.
Topics: Angiotensin II; Angiotensinogen; Animals; Anti-Arrhythmia Agents; Antisense Elements (Genetics); Blotting, Southern; Cells, Cultured; Fibroblasts; Gene Expression; Heart Ventricles; Imidazoles; In Vitro Techniques; Iodine Radioisotopes; Losartan; Muscle Fibers, Skeletal; Myocardial Contraction; Myocardium; Peptidyl-Dipeptidase A; Pyridines; Radioligand Assay; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Renin; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stress, Mechanical | 1999 |
Angiotensin II stimulates DNA and protein synthesis in vascular smooth muscle cells from human arteries: role of extracellular signal-regulated kinases.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Arteries; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; DNA; DNA Replication; Humans; Imidazoles; Losartan; Muscle, Smooth, Vascular; Protein Biosynthesis; Pyridines; Receptors, Angiotensin; Signal Transduction; Vasoconstrictor Agents | 1999 |
The effects of angiotensin II on blood perfusion in the rat renal papilla.
Topics: Angiotensin II; Animals; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Kidney Medulla; Laser-Doppler Flowmetry; Losartan; Nitroarginine; Nitroprusside; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B2; Regional Blood Flow; Renal Circulation; Ultrasonography | 1999 |
Angiotensin IV stimulates plasminogen activator inhibitor-1 expression in proximal tubular epithelial cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Anti-Bacterial Agents; Antihypertensive Agents; Blotting, Northern; Cell Division; Cell Line, Transformed; Epithelial Cells; Fibrosis; Gene Expression; Humans; Kidney Diseases; Kidney Tubules, Proximal; Losartan; Peptides; Plasminogen Activator Inhibitor 1; Protease Inhibitors; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Tissue Plasminogen Activator; Transforming Growth Factor beta; Urokinase-Type Plasminogen Activator | 1999 |
Modulation of vascular development and injury by angiotensin II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Carotid Arteries; Catheterization; DNA; Embryonic and Fetal Development; Female; Imidazoles; Losartan; Male; Muscle, Smooth, Vascular; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 1999 |
Role of angiotensin in renal sympathetic activation in cirrhotic rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Common Bile Duct; Kidney; Ligation; Liver Cirrhosis, Experimental; Losartan; Male; Natriuresis; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Reference Values; Sympathetic Nervous System | 1999 |
Interactions between angiotensin II and nitric oxide during exercise in normal and heart failure rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Female; Heart Diseases; Heart Rate; Losartan; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Physical Conditioning, Animal; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Regional Blood Flow | 1999 |
Renal hemodynamic responses to intrarenal infusion of ligands for the putative angiotensin IV receptor in anesthetized rats.
Topics: Anesthesia; Angiotensin II; Animals; Hemodynamics; Hemoglobins; Kidney; Losartan; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin | 1999 |
Absence of effect of chronic angiotensin II type 1 receptor blockade on endogenous kinin concentrations-induced paw edema model in the rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Carrageenan; Dose-Response Relationship, Drug; Edema; Excipients; Inflammation; Kinins; Losartan; Male; Rats; Rats, Wistar; Receptors, Angiotensin | 1999 |
Comparative effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor antagonism on plasma fibrinolytic balance in humans.
Topics: Adult; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Data Interpretation, Statistical; Diet, Sodium-Restricted; Female; Fibrinolysis; Heart Rate; Humans; Isoquinolines; Losartan; Male; Plasminogen Activator Inhibitor 1; Quinapril; Renin; Renin-Angiotensin System; Tetrahydroisoquinolines; Tissue Plasminogen Activator | 1999 |
Renin activity and blood pressure in response to chronic episodic hypoxia.
Topics: Adrenal Medulla; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Chemoreceptor Cells; Chromatography, High Pressure Liquid; Chronic Disease; Circadian Rhythm; Data Interpretation, Statistical; Denervation; Hemodynamics; Hypertension; Hypoxia; Kidney; Losartan; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Recurrence; Renal Artery; Renin; Renin-Angiotensin System; Sleep Apnea Syndromes; Sympathetic Nervous System; Time Factors | 1999 |
Endothelin, but not angiotensin II, contributes to the hypoxic contractile response of large isolated pulmonary arteries in the rat.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Azepines; Bosentan; Calcium; Calcium Channel Blockers; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Extracellular Space; Glycopeptides; Hypoxia; In Vitro Techniques; Indoles; Lisinopril; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Pulmonary Artery; Rats; Rats, Wistar; Sulfonamides | 1999 |
Targeting TGF-beta overexpression: maximizing the antifibrotic actions of angiotensin II blockade in anti-Thy1 glomerulonephritis.
Topics: Angiotensin II; Animals; Enalapril; Glomerulonephritis; Losartan; Male; Rats; Rats, Sprague-Dawley; Thy-1 Antigens; Transforming Growth Factor beta | 1999 |
Interaction of the autonomic nervous and the renin-angiotensin system in heart and kidney.
Topics: Angiotensin II; Autonomic Nervous System; Heart; Humans; Imidazoles; Kidney; Losartan; Norepinephrine; Renin-Angiotensin System; Tetrazoles | 1999 |
Angiotensin II receptor antagonists in the pharmacological therapy of portal hypertension: a caution.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Humans; Hypertension, Portal; Losartan | 1999 |
Angiotensin II induces LOX-1, the human endothelial receptor for oxidized low-density lipoprotein.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Cells, Cultured; Coronary Artery Bypass; Coronary Artery Disease; Down-Regulation; Endothelium, Vascular; Humans; Losartan; Mammary Arteries; Receptors, LDL; Receptors, Oxidized LDL; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Scavenger Receptors, Class E; Umbilical Veins | 1999 |
Aminopeptidase A activity and angiotensin III effects on [Ca2+]i along the rat nephron.
Topics: Aminopeptidases; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Calcium; Glutamyl Aminopeptidase; Imidazoles; Immunohistochemistry; In Vitro Techniques; Intracellular Fluid; Losartan; Male; Nephrons; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, Angiotensin | 1999 |
Downregulation of cardiac AT1-receptor expression and angiotensin II concentrations after long-term blockade of the renin-angiotensin system in cardiomyopathic hamsters.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Cardiomegaly; Cricetinae; Down-Regulation; Heart Ventricles; Losartan; Male; Mesocricetus; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin-Angiotensin System | 1999 |
Characterization of a functional AT1A angiotensin receptor in pancreatoma AR4-2J cells.
Topics: Amylases; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Base Sequence; Cell Line; DNA Primers; Inositol Phosphates; Kinetics; Losartan; Oligopeptides; Pancreas; Rats; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 1999 |
Interactions between AT1 and AT2 receptors in uterine arteries from pregnant ewes.
Topics: Angiotensin I; Angiotensin II; Animals; Anti-Arrhythmia Agents; Arteries; Female; Hypersensitivity; In Vitro Techniques; Losartan; Muscle Contraction; Muscle, Smooth, Vascular; Pregnancy; Pregnancy, Animal; Receptors, Angiotensin; Sheep; Uterus | 1999 |
Action of AT1 receptor antagonists on angiotensin II-induced tone in human isolated subcutaneous resistance arteries.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Arteries; Benzimidazoles; Biphenyl Compounds; Endothelium, Vascular; Humans; Imidazoles; Losartan; Muscle Tonus; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles; Vasoconstrictor Agents | 1999 |
EXP3174, the AII antagonist human metabolite of losartan, but not losartan nor the angiotensin-converting enzyme inhibitor captopril, prevents the development of lethal ischemic ventricular arrhythmias in a canine model of recent myocardial infarction.
Topics: Analysis of Variance; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Captopril; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Female; Heart Ventricles; Humans; Imidazoles; Losartan; Male; Myocardial Infarction; Myocardial Ischemia; Tetrazoles; Time Factors | 1999 |
Angiotensin regulates the selectivity of the Na+-K+ pump for intracellular Na+.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Animals; Captopril; Electrophysiology; Enzyme Activation; Extracellular Space; Heart Ventricles; Intracellular Membranes; Losartan; Male; Myocardium; Potassium; Protein Kinase C; Rabbits; Sodium; Sodium-Potassium-Exchanging ATPase | 1999 |
Salt-sensitive hypertension in ANP knockout mice is prevented by AT1 receptor antagonist losartan.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Hypertension; Losartan; Mice; Mice, Knockout; Sodium Chloride, Dietary | 1999 |
Differing effects of enalapril and losartan on renal medullary blood flow and renal interstitial hydrostatic pressure in spontaneously hypertensive rats.
Topics: Adrenergic beta-Antagonists; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Bradykinin; Enalapril; Hydrostatic Pressure; Kidney Medulla; Laser-Doppler Flowmetry; Losartan; Male; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renal Circulation | 1999 |
Renal responses to AT1 blockade in angiotensin II-induced hypertensive rats.
Topics: Analysis of Variance; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Glomerular Filtration Rate; Hypertension, Renal; Losartan; Male; Rats; Rats, Sprague-Dawley; Renal Circulation; Sodium | 1997 |
Effects of the angiotensin II antagonist losartan on endothelin-1 and norepinephrine plasma levels during cold pressor test in patients with chronic heart failure.
Topics: Aged; Aged, 80 and over; Angiotensin II; Antihypertensive Agents; Blood Pressure; Chronic Disease; Cold Temperature; Endothelin-1; Exercise Test; Female; Heart Failure; Heart Rate; Humans; Losartan; Male; Middle Aged; Norepinephrine; Sympathetic Nervous System; Vasoconstriction | 1999 |
Role of angiotensin II in glucose-induced inhibition of mesangial matrix degradation.
Topics: Angiotensin II; Animals; Collagenases; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix; Glomerular Mesangium; Glucose; Losartan; Molecular Weight; Rats; Transforming Growth Factor beta | 1999 |
Effects of the insurmountable angiotensin AT1 receptor antagonist candesartan and the surmountable antagonist losartan on ischemia/reperfusion injury in rat hearts.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Creatine Kinase; Dose-Response Relationship, Drug; Heart; Hemodynamics; In Vitro Techniques; Losartan; Male; Myocardial Reperfusion Injury; Norepinephrine; Perfusion; Pressure; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles; Time Factors; Vasoconstriction; Vasoconstrictor Agents | 1999 |
Angiotensin II stimulates intercellular adhesion molecule-1 (ICAM-1) expression by human vascular endothelial cells and increases soluble ICAM-1 release in vivo.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Atenolol; Cells, Cultured; Endothelium, Vascular; Female; Gene Expression Regulation; Humans; Hypertension; Intercellular Adhesion Molecule-1; Losartan; Male; Middle Aged; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger; Umbilical Veins | 1999 |
Effect of renal perfusion pressure on renal function, renin release and renin and angiotensinogen gene expression in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Animals; Blood Pressure; Blotting, Northern; Feedback; Gene Expression; Glyceraldehyde-3-Phosphate Dehydrogenases; In Situ Hybridization; Inulin; Kidney; Losartan; Rats; Rats, Wistar; Renal Circulation; Renin | 1999 |
In vivo study of AT(1) and AT(2) angiotensin receptors in apoptosis in rat blood vessels.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta; Apoptosis; Blood Pressure; Body Weight; Drug Interactions; Imidazoles; Losartan; Male; Muscle Development; Muscle, Smooth, Vascular; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vasoconstrictor Agents | 1999 |
Activation of AT(2) receptors by endogenous angiotensin II is involved in flow-induced dilation in rat resistance arteries.
Topics: Analysis of Variance; Angiotensin II; Animals; Antihypertensive Agents; Blotting, Western; Imidazoles; Losartan; Mesenteric Arteries; Pyridines; Rats; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; Saralasin; Stress, Mechanical; Vascular Resistance; Vasodilation | 1999 |
Delayed recovery of hypertension after single dose losartan in angiotensin II-infused conscious rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Drug Interactions; Hypertension; Infusions, Intravenous; Losartan; Male; Rats; Rats, Sprague-Dawley; Time Factors; Vasoconstrictor Agents | 1999 |
Activation of the AT(2) receptor of angiotensin II induces neurite outgrowth and cell migration in microexplant cultures of the cerebellum.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blotting, Western; Cell Differentiation; Cell Movement; Cerebellum; Culture Techniques; Fluorescent Antibody Technique, Indirect; Imidazoles; Losartan; Microtubule-Associated Proteins; Neurites; Oligopeptides; Pyridines; Rats; Rats, Long-Evans; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Signal Transduction; tau Proteins; Tubulin | 1999 |
Angiotensin II receptor antagonists prevent neointimal proliferation in a porcine coronary artery organ culture model.
Topics: Analysis of Variance; Angioplasty, Balloon, Coronary; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Captopril; Cell Division; Coronary Disease; Coronary Vessels; Culture Techniques; Imidazoles; Losartan; Muscle, Smooth, Vascular; Pyridines; Recurrence; Swine; Tetrazoles | 1999 |
Arterial function in nitric oxide-deficient hypertension: influence of long-term angiotensin II receptor antagonism.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cromakalim; Cyclooxygenase Inhibitors; Diclofenac; Hypertension; In Vitro Techniques; Isoproterenol; Losartan; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Rats; Rats, Wistar; Vasodilator Agents | 1999 |
Angiotensin-(1-7) binds at the type 1 angiotensin II receptors in rat renal cortex.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding Sites; Imidazoles; Iodine Radioisotopes; Kidney Cortex; Losartan; Male; Peptide Fragments; Pyridines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Angiotensin | 1999 |
Renal effects of angiotensin II receptor subtype 1 and 2-selective ligands injected into the paraventricular nucleus of conscious rats.
Topics: Angiotensin II; Animals; Injections, Intraventricular; Kidney; Ligands; Losartan; Male; Oligopeptides; Paraventricular Hypothalamic Nucleus; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Saralasin; Sodium | 1999 |
Renal and vascular effects of chronic nitric oxide synthase inhibition: involvement of endothelin 1 and angiotensin II.
Topics: Angiotensin II; Animals; Blood Pressure; Endothelin-1; Enzyme Inhibitors; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley | 1999 |
Central administration of zinc increases renal sodium and potassium excretion in rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Brain Chemistry; Calcium Channels; Gadolinium; Injections, Intraventricular; Kidney; Losartan; Male; Potassium; Rats; Rats, Wistar; Sodium; Third Ventricle; Urination; Water-Electrolyte Balance; Zinc | 1999 |
Chronic AT1 receptor blockade and angiotensin-converting enzyme (ACE) inhibition in (CHF 146) cardiomyopathic hamsters: effects on cardiac hypertrophy and survival.
Topics: Alanine Transaminase; Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiomyopathy, Dilated; Creatinine; Cricetinae; Evaluation Studies as Topic; Isoquinolines; Losartan; Male; Mesocricetus; Myocardium; Potassium; Quinapril; Sodium; Tetrahydroisoquinolines | 1999 |
Angiotensin II receptor blockade during gestation attenuates collagen formation in the developing rat heart.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Birth Weight; Blotting, Western; Collagen; Female; Heart; Imidazoles; In Situ Hybridization; Losartan; Organ Size; Pregnancy; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta | 1999 |
Water drinking in rats resulting from intravenous relaxin and its modification by other dipsogenic factors.
Topics: Angiotensin II; Angiotensins; Animals; Drinking; Drug Synergism; Female; Infusions, Intravenous; Injections, Intraventricular; Kinetics; Losartan; Male; Rats; Rats, Sprague-Dawley; Relaxin; Saline Solution, Hypertonic; Sodium Chloride | 1999 |
Participation of angiotensin receptors in acute hypoxia in mice. II. Effects of angiotensin II nonpeptide receptor ligands losartan (DuP-753) and PD-123319.
Topics: Acute Disease; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Hypoxia, Brain; Imidazoles; Injections, Intraventricular; Ligands; Losartan; Male; Mice; Mice, Inbred ICR; Pyridines; Receptors, Angiotensin; Seizures; Vasoconstrictor Agents | 1999 |
Antagonistic effects of losartan on thromboxane A2-receptors in human isolated gastroepiploic artery and saphenous vein.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelin-1; Humans; In Vitro Techniques; Indomethacin; Losartan; Muscle Contraction; Muscle, Smooth, Vascular; Nitroarginine; Norepinephrine; Potassium Chloride; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Saphenous Vein; Serotonin; Stomach | 1999 |
Differential effects of angiotensin II on cardiorespiratory reflexes mediated by nucleus tractus solitarii - a microinjection study in the rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Bradycardia; Chemoreceptor Cells; Heart Rate; Losartan; Microinjections; Neurokinin-1 Receptor Antagonists; Phrenic Nerve; Piperidines; Pressoreceptors; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Reflex; Respiration; Respiratory Physiological Phenomena; Solitary Nucleus; Substance P | 1999 |
Losartan reduces the vasorelaxant effect of atrial natriuretic peptide on basal tone in aorta.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Atrial Natriuretic Factor; Calcium; Female; Imidazoles; In Vitro Techniques; Intracellular Fluid; Isotonic Solutions; Losartan; Male; Muscle, Smooth, Vascular; Pyridines; Rabbits; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Vascular Resistance; Vasodilation | 1999 |
Angiotensin II stimulates proliferation of adventitial fibroblasts cultured from rat aortic explants.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Blotting, Northern; Cell Division; Cells, Cultured; DNA; Fibroblasts; Gene Expression; Genes, Immediate-Early; Growth Substances; Hyperplasia; Losartan; Male; Proto-Oncogenes; Rats; Rats, Sprague-Dawley; RNA | 1999 |
Pharmacological characterization of KR-30988, a novel non-peptide AT1 receptor antagonist, in rat, rabbit and dog.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Dogs; Furosemide; Hypertension, Renal; Imidazoles; Losartan; Male; Oligopeptides; Pressoreceptors; Rabbits; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Recombinant Proteins; Tetrazoles; Vasoconstriction | 1999 |
Comparative study of TA-606, a novel angiotensin II receptor antagonist, with losartan in terms of species difference and orthostatic hypotension.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Dogs; Dose-Response Relationship, Drug; Hypertension, Renal; Hypotension, Orthostatic; Imidazoles; Losartan; Male; Prodrugs; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Species Specificity; Tetrazoles | 1999 |
Renal vascular reactivity in mice: AngII-induced vasoconstriction in AT1A receptor null mice.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Female; Imidazoles; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligopeptides; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renal Circulation; Renin; Vasoconstriction | 1999 |
The effects of angiotensin metabolites on the regulation of coagulation and fibrinolysis in cultured rat aortic endothelial cells.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Aorta; Blood Coagulation; Endothelium, Vascular; Fibrinolysis; Gene Expression Regulation; Imidazoles; Lipoproteins; Losartan; Plasminogen Activator Inhibitor 1; Pyridines; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Thromboplastin; Tissue Plasminogen Activator | 1999 |
[Effect of losartan and enalapril on urinary excretion of 8-isoprostane in experimental nephrotic syndrome].
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Dinoprost; Doxorubicin; Eicosanoids; Enalapril; F2-Isoprostanes; Losartan; Male; Nephrotic Syndrome; Proteinuria; Rats; Rats, Wistar | 1999 |
Angiotensin II and retinal pericytes migration.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cattle; Cell Movement; Chemotaxis; Imidazoles; Losartan; Neovascularization, Physiologic; Pericytes; Pyridines; Retina | 1999 |
Haemodynamic, renal sodium handling, and neurohormonal effects of acute administration of low dose losartan, an angiotensin II receptor antagonist, in preascitic cirrhosis.
Topics: Adult; Aged; Angiotensin II; Angiotensin Receptor Antagonists; Ascites; Dose-Response Relationship, Drug; Hemodynamics; Homeostasis; Humans; Kidney; Liver Cirrhosis; Losartan; Male; Middle Aged; Sodium | 2000 |
Differential effects of losartan and doxazosin on vascular function in senescent spontaneously hypertensive rats.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Aging; Angiotensin II; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Doxazosin; Endothelium, Vascular; Hypertension; Losartan; Male; Nitrates; Nitroprusside; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Vasodilation; Vasodilator Agents | 1999 |
Blockade of the renin angiotensin system in heart failure: the potential place of angiotensin II receptor blockers.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Heart Failure; Humans; Losartan; Receptors, Angiotensin; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan | 2000 |
The angiotensin AT(1) receptor antagonist irbesartan has near-peptide affinity and potently blocks receptor signaling.
Topics: Adrenal Glands; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Biphenyl Compounds; Cells, Cultured; Dose-Response Relationship, Drug; Iodine Radioisotopes; Irbesartan; Kidney; Liver; Losartan; Male; PC12 Cells; Pituitary Gland; Pyrimidines; Radioligand Assay; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Signal Transduction; Tetrazoles | 1999 |
Effects of angiotensin II and antagonists on AT(1) receptor expression in mesangial cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Dexamethasone; Dose-Response Relationship, Drug; Gene Expression Regulation; Glomerular Mesangium; Imidazoles; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger; Tetrazoles | 1999 |
Angiotensin II modulates conducted vasoconstriction to norepinephrine and local electrical stimulation in rat mesenteric arterioles.
Topics: Adrenergic alpha-Agonists; Angiotensin II; Animals; Arterioles; Electric Stimulation; Losartan; Male; Mesenteric Arteries; Methoxamine; Microscopy, Video; Norepinephrine; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Vasoconstrictor Agents | 1999 |
Angiotensin II-induced superoxide anion generation in human vascular endothelial cells: role of membrane-bound NADH-/NADPH-oxidases.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Imidazoles; Lisinopril; Losartan; NADH Dehydrogenase; NADPH Oxidases; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; Stimulation, Chemical; Superoxides | 1999 |
Changes in angiotensin converting enzyme activity in the renal vascular bed of streptozotocin-induced diabetic rat.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Glucose; Captopril; Diabetes Mellitus, Experimental; Drug Interactions; Kidney; Losartan; Male; Muscle, Smooth, Vascular; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Renal Artery; Streptozocin; Vasoconstriction | 1999 |
Angiotensin III depressor action in the conscious rabbit is blocked by losartan but not PD 123319.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Imidazoles; Losartan; Male; Peptide Fragments; Pyridines; Rabbits; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 2000 |
Angiotensin II enhances integrin and alpha-actinin expression in adult rat cardiac fibroblasts.
Topics: Actinin; Age Factors; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antigens, CD; Antihypertensive Agents; Biphenyl Compounds; Cardiomegaly; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Collagen; Fibroblasts; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Heart Ventricles; Hydralazine; Imidazoles; Integrin alphaV; Integrin beta Chains; Integrin beta1; Integrin beta3; Integrins; Irbesartan; Laminin; Losartan; Myocardium; Phosphorylation; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger; Tetrazoles; Up-Regulation; Vitronectin | 2000 |
Elevated sympathetic activity contributes to hypertension and salt sensitivity in diabetic obese Zucker rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Carotid Arteries; Circadian Rhythm; Diabetes Mellitus; Diabetes Mellitus, Type 2; Ganglionic Blockers; Heart Rate; Hexamethonium; Hypertension; Losartan; Male; Obesity; Rats; Rats, Zucker; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Sodium Chloride, Dietary; Sympathetic Nervous System; Vasoconstriction | 2000 |
Angiotensin AT1 receptors in the preoptic area negatively modulate the cardiovascular and ACTH responses induced in rats by intrapreoptic injection of prostaglandin E2.
Topics: Adrenocorticotropic Hormone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Cardiovascular System; Dinoprostone; Injections; Losartan; Male; Oligopeptides; Preoptic Area; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 2000 |
Effects of central infusion of ANG II and losartan on the cardiac baroreflex in rabbits.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Brain; Cardiovascular System; Dose-Response Relationship, Drug; Female; Heart; Heart Rate; Hemodynamics; Injections, Intravenous; Injections, Intraventricular; Losartan; Male; Rabbits | 2000 |
Role of angiotensin II in regulation of basal and sympathetically stimulated vascular tone in early and advanced cirrhosis.
Topics: Adult; Angiotensin II; Antihypertensive Agents; Blood Vessels; Disease Progression; Dose-Response Relationship, Drug; Female; Forearm; Hemodynamics; Humans; Liver Cirrhosis; Losartan; Lower Body Negative Pressure; Male; Middle Aged; Norepinephrine; Regional Blood Flow; Sympathetic Nervous System; Vasoconstrictor Agents; Vasomotor System | 2000 |
Modulation of the AT2 subtype receptor gene activation and expression by the AT1 receptor in endothelial cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Endothelium, Vascular; Gene Expression; Gene Expression Regulation; Imidazoles; Losartan; Promoter Regions, Genetic; Pyridines; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger; Transcriptional Activation | 1999 |
Brain AT(2) receptor mediate vasodepressor response to footshocks: role of kinins and nitric oxide.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Brain; Electroshock; Enzyme Inhibitors; Extremities; Heart Rate; Imidazoles; Injections, Intraventricular; Losartan; Male; Nitric Oxide Synthase; Nitroarginine; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptor, Bradykinin B2; Receptors, Angiotensin | 2000 |
ELITE II. AT1-blockers not better, but more tolerable than ACE-inhibitors.
Topics: Aged; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Captopril; Female; Heart Failure; Humans; Losartan; Male; Randomized Controlled Trials as Topic; Survival Analysis; Treatment Outcome | 2000 |
Angiotensin stimulates TGF-beta1 and clusterin in the hydronephrotic neonatal rat kidney.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Clusterin; Glycoproteins; Imidazoles; Kidney; Losartan; Molecular Chaperones; Pyridines; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta; Ureteral Obstruction; Vasoconstrictor Agents | 2000 |
Paracrine effects of angiotensin-converting-enzyme- and angiotensin-II-receptor- inhibition on transcapillary glucose transport in humans.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Biological Transport; Bradykinin; Capillaries; Enalapril; Glucose; Humans; Hyperinsulinism; Losartan; Male; Receptors, Angiotensin | 2000 |
Comparative effects of pretreatment with captopril and losartan on cardiovascular protection in a rat model of ischemia-reperfusion.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Arrhythmia Agents; Captopril; Disease Models, Animal; Electrocardiography; Female; Heart Rate; Losartan; Myocardial Infarction; Myocardial Reperfusion Injury; Random Allocation; Rats; Rats, Sprague-Dawley; Renin; Treatment Outcome; Ventricular Fibrillation | 2000 |
Heme oxygenase-1 is upregulated in the kidney of angiotensin II-induced hypertensive rats : possible role in renoprotection.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cell Line, Transformed; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glomerular Filtration Rate; Heart Rate; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Hydralazine; Hypertension; Immunohistochemistry; Kidney Tubules, Proximal; Losartan; Norepinephrine; Oxidative Stress; Proteinuria; Protoporphyrins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Vasoconstrictor Agents; Vasodilator Agents | 2000 |
Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers.
Topics: 2,4-Dinitrophenol; Angiotensin II; Animals; Anti-Arrhythmia Agents; Antimetabolites; Biological Transport, Active; Caco-2 Cells; Cell Line; Chromatography, Liquid; Dogs; Energy Metabolism; Epithelium; Humans; Imidazoles; Kidney; Kinetics; LLC-PK1 Cells; Losartan; Mass Spectrometry; Multidrug Resistance-Associated Protein 2; Swine; Temperature; Tetrazoles | 2000 |
Angiotensin II mediates pressure loading-induced mitogen-activated protein kinase activation in isolated rat aorta.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Calcium; Calcium Channel Blockers; Captopril; Enzyme Activation; In Vitro Techniques; Ion Channel Gating; Losartan; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Nifedipine; Pepstatins; Rats; Rats, Wistar; Renin; Stress, Mechanical | 2000 |
Angiotensin II type 1 receptor-function affected by mutations in cytoplasmic loop CD.
Topics: Amino Acid Sequence; Amino Acid Substitution; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding Sites; Cattle; Chlorides; COS Cells; Heterotrimeric GTP-Binding Proteins; Histidine; Inositol Phosphates; Kinetics; Losartan; Models, Molecular; Molecular Sequence Data; Mutation; Protein Structure, Secondary; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Rhodopsin; Sequence Alignment; Signal Transduction; Thermodynamics; Zinc Compounds | 2000 |
Morphological and immunocytochemical characterization of electrophysiologically investigated neurons in the PVN of the rat.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Cell Size; Fluorescent Dyes; Immunohistochemistry; Isoquinolines; Losartan; Male; Neurons; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasopressins | 2000 |
Role of angiotensin II AT1 and AT2 subtype receptors in the regulation of atrial natriuretic peptide expression in salt-restricted rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Imidazoles; Losartan; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Sodium Chloride | 2000 |
[Effect of losartan on human platelet activation by thromboxane A2].
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adult; Angiotensin II; Humans; Imidazoles; Losartan; Male; Platelet Activation; Receptors, Thromboxane; Tetrazoles; Thromboxane A2 | 2000 |
Interaction between Mas and the angiotensin AT1 receptor in the amygdala.
Topics: Action Potentials; Amygdala; Angiotensin II; Animals; Antihypertensive Agents; Electrophysiology; Immunoenzyme Techniques; In Vitro Techniques; Losartan; Mice; Mice, Knockout; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Receptors, G-Protein-Coupled; Saralasin; Vasoconstrictor Agents | 2000 |
Angiotensin II blockade and low-protein diet produce additive therapeutic effects in experimental glomerulonephritis.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Diet, Protein-Restricted; Enalapril; Glomerulonephritis; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Transforming Growth Factor beta; Treatment Outcome | 2000 |
Activation of renal afferent pathways following furosemide treatment. II. Effect Of angiotensin blockade.
Topics: Afferent Pathways; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Brain Stem; Captopril; Diuretics; Furosemide; Hypothalamus; Hypovolemia; Kidney; Losartan; Male; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Subfornical Organ | 2000 |
Effect of intrarenal infusion of angiotensin-(1-7) in the dog.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Diuresis; Dogs; Female; Glomerular Filtration Rate; Imidazoles; Infusions, Intra-Arterial; Kidney; Losartan; Male; Peptide Fragments; Receptors, Angiotensin; Renal Artery; Renal Circulation; Tetrazoles; Urodynamics; Vasodilator Agents | 2000 |
Hypotensive effect of angiotensin II after AT1-receptor blockade with losartan.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Drug Synergism; Hypotension; Injections, Intravenous; Losartan; Male; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Vasoconstrictor Agents | 2000 |
Blockade of angiotensin receptors in the anterior hypothalamic preoptic area lowers blood pressure in DOCA-salt hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Desoxycorticosterone; Dose-Response Relationship, Drug; Hypertension; Hypothalamus, Anterior; Injections, Intraventricular; Losartan; Male; Preoptic Area; Rats; Rats, Wistar; Receptors, Angiotensin; Reference Values; Sodium Chloride; Vasoconstrictor Agents | 2000 |
Synergistic effects of AT(1) and ET(A) receptor blockade in a transgenic, angiotensin II-dependent, rat model.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Genetically Modified; Antihypertensive Agents; Blood Pressure; Drug Synergism; Endothelin Receptor Antagonists; Endothelin-1; Humans; Hypertension; Losartan; Phenylpropionates; Pyrimidines; Rats; Renin | 2000 |
Direct interaction between the sympathetic and renin-angiotensin system in myocardial tissue: a microdialysis study in anaesthetised rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Heart; Losartan; Male; Microdialysis; Myocardium; Norepinephrine; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin-Angiotensin System; Sympathetic Nervous System; Vasoconstrictor Agents | 2000 |
Mechanism of reduced GFR in rabbits with ischemic acute renal failure.
Topics: Acute Kidney Injury; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biomarkers; Creatinine; Enalapril; Female; Glomerular Filtration Rate; Ischemia; Kidney; Kidney Tubules; Losartan; Male; Rabbits; Renal Circulation; Urodynamics | 2000 |
Aldosterone mediates angiotensin II-stimulated rat vascular smooth muscle cell proliferation.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Cell Division; Cells, Cultured; Cytochrome P-450 CYP11B2; Drug Synergism; Losartan; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Spironolactone; Stimulation, Chemical | 2000 |
[Vascular diseases and thrombosis].
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Coronary Thrombosis; Humans; Losartan; Risk Factors; Ventricular Fibrillation | 2000 |
[Clinical efficacy of losartan: are there any differences between angiotensin II type I receptor antagonists and other drugs?].
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Humans; Hypertension; Losartan; Receptors, Angiotensin | 2000 |
Proapoptotic and growth-inhibitory role of angiotensin II type 2 receptor in vascular smooth muscle cells of spontaneously hypertensive rats in vivo.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Apoptosis; Cell Division; Enalapril; Hypertension; Losartan; Muscle, Smooth, Vascular; Rats; Rats, Inbred SHR; Receptors, Angiotensin | 2000 |
Tissue angiotensin II and endothelin-1 modulate differently the response to flow in mesenteric resistance arteries of normotensive and spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Viscosity; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Imidazoles; Losartan; Mesenteric Arteries; Muscle Tonus; Perindopril; Phenylpropionates; Pyridines; Pyrimidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Splanchnic Circulation; Vascular Resistance; Vasodilation | 2000 |
AT(1) receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factor.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antibodies; Cells, Cultured; CHO Cells; Coronary Vessels; Cricetinae; Enzyme Activation; Female; Humans; Losartan; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Placenta; Pre-Eclampsia; Pregnancy; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reference Values; Thromboplastin; Transcription Factor AP-1; Transfection | 2000 |
Angiotensin II modulates ion transport in rat proximal tubules through CYP metabolites.
Topics: Adrenalectomy; Angiotensin II; Animals; Arachidonic Acid; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; Indomethacin; Ion Transport; Kidney Tubules, Proximal; Losartan; Male; Ouabain; Rats; Rats, Sprague-Dawley; Rubidium Radioisotopes | 2000 |
Angiotensin II induces contraction and proliferation of human hepatic stellate cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Cell Division; Cell Size; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Humans; Imidazoles; Indomethacin; Iodine Radioisotopes; Liver; Losartan; Mitogen-Activated Protein Kinases; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Penicillamine; Pyridines; Radioligand Assay; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Sodium Nitrite; Thymidine; Vasoconstrictor Agents | 2000 |
Interaction between norepinephrine release and intrarenal angiotensin II formation during renal nerve stimulation in dogs.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Dogs; Enalaprilat; Female; Kidney; Losartan; Male; Norepinephrine; Renal Circulation; Sympathetic Nervous System; Time Factors | 2000 |
Comparative effects of angiotensin II AT-1-type receptor antagonists in vitro on human platelet activation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antibodies, Monoclonal; Benzimidazoles; Benzoates; Binding, Competitive; Biphenyl Compounds; Blood Platelets; Dose-Response Relationship, Drug; Humans; Imidazoles; Irbesartan; Losartan; Platelet Activation; Pyridines; Radioligand Assay; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Telmisartan; Tetrazoles; Thromboxane A2; Time Factors; Valine; Valsartan | 2000 |
Molecular cloning of a ferret angiotensin II AT(1) receptor reveals the importance of position 163 for Losartan binding.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Alanine; Amino Acid Sequence; Amino Acid Substitution; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Base Sequence; Binding Sites; Binding, Competitive; Cloning, Molecular; COS Cells; DNA, Complementary; DNA, Recombinant; Ferrets; Imidazoles; Iodine Radioisotopes; Losartan; Molecular Sequence Data; Plasmids; Protein Binding; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Threonine | 2000 |
Increased central AT(1)-receptor activation, not systemic vasopressin, sustains hypertension in ANP knockout mice.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Arginine Vasopressin; Atrial Natriuretic Factor; Blood Pressure; Female; Hormone Antagonists; Hypertension; Injections, Intravenous; Losartan; Male; Mice; Mice, Knockout; Paraventricular Hypothalamic Nucleus; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Vasopressins | 2000 |
Decreased binding sites of angiotensin II in rat LY-80 and AH109A tumour and human gastric cancer using quantitative in vitro autoradiography.
Topics: Aged; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Autoradiography; Binding Sites; Biomarkers, Tumor; Blood Flow Velocity; Carcinoma; Humans; Imidazoles; Losartan; Male; Middle Aged; Neoplasm Transplantation; Neoplasms, Experimental; Pyridines; Rats; Rats, Nude; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Skin Neoplasms; Stomach Neoplasms; Tumor Cells, Cultured | 2000 |
Regional renal haemodynamics of angiotensin II infusion under prostaglandin, kinin or converting enzyme inhibition in the Wistar rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Aprotinin; Bradykinin; Enalapril; Hemodynamics; Ketoprofen; Kidney Medulla; Losartan; Male; Nitric Oxide; Prostaglandin Antagonists; Rats; Rats, Wistar; Renal Circulation | 2000 |
An angiotensin system in the anterior hypothalamic area anterior is involved in the maintenance of hypertension in spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensins; Animals; Anterior Hypothalamic Nucleus; Antihypertensive Agents; Blood Pressure; Carbachol; Hypertension; Losartan; Male; Microinjections; Perfusion; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2000 |
Contribution of angiotensin II to late renal injury after acute ischemia.
Topics: Acute Disease; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Disease Progression; Enalapril; Ischemia; Kidney; Losartan; Male; Rats; Rats, Sprague-Dawley; Renal Circulation; Time Factors | 2000 |
Differential inhibition of the prejunctional actions of angiotensin II in rat atria by valsartan, irbesartan, eprosartan, and losartan.
Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Heart; Imidazoles; Irbesartan; Losartan; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Angiotensin; Sympathetic Nervous System; Tetrazoles; Thiophenes; Valine; Valsartan | 2000 |
Angiotensin-converting enzyme-independent angiotensin formation in a human model of myocardial ischemia: modulation of norepinephrine release by angiotensin type 1 and angiotensin type 2 receptors.
Topics: Aged; Angiotensin II; Chymases; Female; Humans; Imidazoles; Losartan; Male; Middle Aged; Myocardial Ischemia; Norepinephrine; Peptidyl-Dipeptidase A; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Serine Endopeptidases; Tetrazoles | 2000 |
Losartan inhibits cellular uptake of oxidized LDL by monocyte-macrophages from hypercholesterolemic patients.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Arteriosclerosis; Biological Transport, Active; CD36 Antigens; Gene Expression; Humans; Hypercholesterolemia; In Vitro Techniques; Lipoproteins, LDL; Losartan; Macrophages; Monocytes; Oxidation-Reduction; RNA, Messenger | 2000 |
Renin angiotensin system of rabbit clitoral cavernosum: interaction with nitric oxide.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Clitoris; Culture Techniques; Female; Imidazoles; Losartan; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Pyridines; Rabbits; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2000 |
Trauma- and sepsis-induced hepatic ischemia and reperfusion injury: role of angiotensin II.
Topics: Analysis of Variance; Angiotensin II; Animals; Burns; Drug Evaluation, Preclinical; Escherichia coli; Female; Hemodynamics; Ischemia; Lipopolysaccharides; Liver; Losartan; Random Allocation; Reperfusion Injury; Sepsis; Swine; Swine, Miniature; Wounds and Injuries | 2000 |
Octreotide-induced drinking, vasopressin, and pressure responses: role of central angiotensin and ACh.
Topics: Acetylcholine; Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Behavior, Animal; Blood Pressure; Dose-Response Relationship, Drug; Drinking; Injections, Intraventricular; Injections, Subcutaneous; Losartan; Male; Muscarinic Antagonists; Narcotic Antagonists; Octreotide; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Saralasin; Vasopressins | 2000 |
Reinforcement of arteriolar myogenic activity by endogenous ANG II: susceptibility to dietary salt.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arterioles; Blood Pressure; Bradykinin; Diet, Sodium-Restricted; Losartan; Male; Microcirculation; Muscle, Skeletal; Muscle, Smooth, Vascular; Rats; Rats, Inbred WKY; Saralasin; Sodium, Dietary | 2000 |
Role of brain angiotensin II in renal nerve inhibition elicited by volume expansion in the conscious rabbit.
Topics: Angiotensin II; Animals; Blood Pressure; Blood Volume; Brain; Consciousness; Heart Rate; Kidney; Losartan; Male; Polygeline; Rabbits; Reflex; Splanchnic Nerves; Water-Electrolyte Balance | 2000 |
Blockade of central angiotensin II does not affect the reduction in renal sympathetic nerve activity following a volume load in heart failure rabbits.
Topics: Angiotensin II; Animals; Antibiotics, Antineoplastic; Blood Pressure; Blood Volume; Doxorubicin; Electrodes; Heart Failure; Heart Rate; Injections, Intraventricular; Kidney; Losartan; Male; Rabbits; Sympathetic Nervous System | 2000 |
Involvement of calcineurin in angiotensin II-induced cardiomyocyte hypertrophy and cardiac fibroblast hyperplasia of rats.
Topics: Angiotensin II; Animals; Animals, Newborn; Atrial Natriuretic Factor; Calcineurin; Calcineurin Inhibitors; Calcium; Cardiomegaly; Cell Division; Cells, Cultured; Cyclosporine; DNA; Fibroblasts; Fura-2; Hyperplasia; Losartan; Myocardium; Protein Kinase C; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger; Signal Transduction | 1999 |
Heme oxygenase-1 is upregulated in the rat heart in response to chronic administration of angiotensin II.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cell Division; Gene Expression Regulation, Enzymologic; Heart; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemodynamics; Hydralazine; Infusions, Intravenous; Kinetics; Losartan; Male; Myocardium; Norepinephrine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic | 2000 |
Effects of acute angiotensin II type 1 receptor antagonism and angiotensin converting enzyme inhibition on plasma fibrinolytic parameters in patients with heart failure.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Circadian Rhythm; Drug Interactions; Enalapril; Fibrinolysis; Heart Failure; Humans; Losartan; Randomized Controlled Trials as Topic; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System | 2000 |
[Angiotensin II antagonists: a promising pathway].
Topics: Aged; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Captopril; Cardiac Output, Low; Chymases; Humans; Losartan; Renin-Angiotensin System; Serine Endopeptidases; Vasodilator Agents | 2000 |
ACE inhibition and AT(1) receptor blockers: efficacy and duration in hypertension.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Blood Pressure Determination; Circadian Rhythm; Delayed-Action Preparations; Evidence-Based Medicine; Humans; Hypertension; Losartan; Patient Compliance; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles | 2000 |
A functional angiotensin II receptor-GFP fusion protein: evidence for agonist-dependent nuclear translocation.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biological Transport; Calcium; Cell Nucleus; CHO Cells; Cricetinae; Fluorescent Dyes; Genes, Reporter; Green Fluorescent Proteins; Indicators and Reagents; Iodine Radioisotopes; Losartan; Luminescent Proteins; Microscopy, Confocal; Quinolinium Compounds; Radioligand Assay; Rats; Receptors, Angiotensin; Recombinant Fusion Proteins; Thiazoles | 2000 |
Angiotensin II releases 20-HETE from rat renal microvessels.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Arachidonic Acids; Arterioles; Capillaries; Cytochrome P-450 Enzyme System; Estrenes; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Imidazoles; Kidney; Losartan; Male; NADP; Phosphodiesterase Inhibitors; Pyridines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Type C Phospholipases | 2000 |
Angiotensin-(1-7) increases osmotic water permeability in isolated toad skin.
Topics: Analysis of Variance; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Anura; Humans; Losartan; Oxytocin; Peptide Fragments; Permeability; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Skin; Skin Absorption; Vasoconstrictor Agents; Vasotocin; Water | 2000 |
Angiotensin II can induce and potentiate shape change in human platelets: effect of losartan.
Topics: Adenosine Diphosphate; Adult; Angiotensin II; Blood Platelets; Cell Size; Drug Synergism; Female; Humans; Indomethacin; Losartan; Male; Middle Aged; Serotonin | 2000 |
Indomethacin prevents the L-NAME-induced increase in plasma levels of oxytocin in dehydrated rats.
Topics: Angiotensin II; Animals; Dehydration; Hypothalamo-Hypophyseal System; Indomethacin; Injections, Intraventricular; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxytocin; Prostaglandins; Rats; Rats, Sprague-Dawley; Vasopressins; Water Deprivation; Water-Electrolyte Balance | 2000 |
Different activation of vascular mitogen-activated protein kinases in spontaneously and DOCA-salt hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Desoxycorticosterone; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Enzyme Activation; Hypertension; In Vitro Techniques; Losartan; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Peptides, Cyclic; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Receptors, Endothelin; Sodium Chloride; Vasoconstrictor Agents | 2000 |
Unchanged cardiac angiotensin II levels accompany losartan-sensitive cardiac injury due to nitric oxide synthase inhibition.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Cardiomegaly; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart; Losartan; Male; Myocardial Infarction; Myocardium; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Vasculitis | 2000 |
[Cardiac and vascular hypertrophy in hypertension due to angiotensin II. Effect of losartan and bosentan].
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Bosentan; Cardiomegaly; Carotid Arteries; Endothelin Receptor Antagonists; Endothelins; Follow-Up Studies; Hypertension; Hypertrophy; Losartan; Male; Organ Size; Rats; Rats, Sprague-Dawley; Sulfonamides | 2000 |
Renin-angiotensin system inhibitors as antihypertrophic agents.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Enalapril; Kidney; Kidney Diseases; Losartan; Nephrectomy; Ramipril; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System | 2000 |
Comparative in vivo effects of irbesartan and losartan on angiotensin II receptor binding in the rat kidney following oral administration.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Kidney; Losartan; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Time Factors | 2000 |
Contribution of central ANG II to acute stress-induced changes in baroreflex function in young rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autonomic Nervous System; Baroreflex; Blood Pressure; Cerebral Ventricles; Heart Rate; Injections, Intravenous; Injections, Intraventricular; Losartan; Male; Nitroprusside; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Restraint, Physical; Stress, Psychological; Sympathetic Nervous System | 2000 |
Effects of angiotensin II on the acrosome reaction in equine spermatozoa.
Topics: Acrosome Reaction; Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium; Cells, Cultured; Drug Synergism; Horses; Immunoblotting; Immunohistochemistry; Intracellular Fluid; Losartan; Male; Progesterone; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Sperm Capacitation; Spermatozoa | 2000 |
H+-ATPase activity on unilateral ureteral obstruction: interaction of endogenous nitric oxide and angiotensin II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Enzyme Activation; Enzyme Inhibitors; Female; Kidney Medulla; Losartan; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Proton-Translocating ATPases; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renal Circulation; Ureteral Obstruction | 2000 |
Effect of angiotensin II blockade on renal injury in mineralocorticoid-salt hypertension.
Topics: Administration, Oral; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Disease Models, Animal; Enalapril; Hypertension, Renal; Kidney; Kidney Function Tests; Losartan; Male; Nephrectomy; Proteinuria; Rats; Rats, Wistar; Renal Insufficiency; Sodium Chloride | 2000 |
Salutary role for angiotensin in partial urinary tract obstruction.
Topics: Angiotensin II; Animals; Kidney; Losartan; Male; Muscle Contraction; Muscle, Smooth; Pelvis; Peristalsis; Rats; Rats, Sprague-Dawley; Ureter; Ureteral Obstruction | 2000 |
Angiotensin II induces leukocyte-endothelial cell interactions in vivo via AT(1) and AT(2) receptor-mediated P-selectin upregulation.
Topics: Angiotensin II; Animals; Cell Communication; Cromolyn Sodium; Endothelium; Flow Cytometry; Imidazoles; Leukocytes; Losartan; P-Selectin; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Up-Regulation | 2000 |
Upregulation of p67(phox) and gp91(phox) in aortas from angiotensin II-infused mice.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Blotting, Western; Hypertension; In Vitro Techniques; Infusions, Parenteral; Losartan; Luminescent Measurements; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; NADPH Oxidase 2; NADPH Oxidases; Organ Specificity; Phosphoproteins; Superoxides; Up-Regulation | 2000 |
Losartan improves recovery of contraction and inhibits transient inward current in a cellular model of cardiac ischemia and reperfusion.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Guinea Pigs; Heart Ventricles; Losartan; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Stunning; Patch-Clamp Techniques; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2 | 2000 |
Interaction of angiotensin II and atrial natriuretic peptide on pH(i) regulation in MDCK cells.
Topics: Acid-Base Equilibrium; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Calcium; Cell Line; Chelating Agents; Dogs; Epithelial Cells; Hydrogen-Ion Concentration; Intracellular Fluid; Kidney; Losartan; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sodium; Sodium-Hydrogen Exchangers | 2000 |
Effects of des-aspartate-angiotensin I on angiotensin II-induced incorporation of phenylalanine and thymidine in cultured rat cardiomyocytes and aortic smooth muscle cells.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Aorta, Thoracic; Cells, Cultured; DNA; Imidazoles; Indomethacin; Losartan; Muscle, Smooth, Vascular; Myocardium; Peptide Fragments; Phenylalanine; Protein Biosynthesis; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Thymidine | 2000 |
Losartan, a selective inhibitor of subtype AT1 receptors for angiotensin II, inhibits neutrophil recruitment in the lung triggered by fMLP.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cell Movement; Chemotaxis, Leukocyte; Hemorrhage; Losartan; Lung; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Pneumonia, Bacterial; Pseudomonas aeruginosa; Pseudomonas Infections; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2 | 2000 |
Contribution of circulating renin to local synthesis of angiotensin peptides in the heart.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Gene Expression Regulation; Humans; Losartan; Mice; Mice, Transgenic; Microscopy, Immunoelectron; Myocardium; Organ Specificity; Peptide Biosynthesis; Renin; Transgenes | 2000 |
Angiotensin II type 1 receptor antagonists. Why do some of them produce insurmountable inhibition?
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Binding Sites; Biphenyl Compounds; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Irbesartan; Losartan; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Recombinant Proteins; Tetrazoles | 2000 |
New approach in the therapy of chronic rejection? ACE- and AT1-blocker reduce the development of chronic rejection after cardiac transplantation in a rat model.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Coronary Disease; Coronary Vessels; Cyclosporine; Enalapril; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Losartan; Male; Premedication; Rats; Rats, Inbred F344; Rats, Inbred Lew; Transplantation, Heterotopic | 2000 |
[Experimental ischemic renal injury--effect of surgical technique and the protective effect of a nonpeptide angiotensin II antagonist (losartan)].
Topics: Angiotensin II; Animals; Creatinine; Ischemia; Kidney; Losartan; Male; Protective Agents; Rats; Rats, Wistar; Time Factors; Urea | 2000 |
Regulation of the myocardial endothelin system by angiotensin-II and losartan.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Endothelin-1; Endothelins; Gene Expression Regulation; Losartan; Male; Myocardium; Protein Precursors; Rats; Rats, Wistar; Receptor, Endothelin B; Receptors, Endothelin; RNA, Messenger | 2000 |
Acid-base and endocrine effects of aldosterone and angiotensin II inhibition in metabolic acidosis in human patients.
Topics: Acid-Base Equilibrium; Acidosis; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Chronic Disease; Electrolytes; Female; Humans; Hydrocortisone; Losartan; Male; Nitrogen; Spironolactone | 2000 |
Angiotensin II infused intrarenally causes preglomerular vascular changes and hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Hypertension; Infusions, Intra-Arterial; Kidney; Losartan; Male; Nephrectomy; Rats; Rats, Sprague-Dawley; Renal Artery; Renal Circulation; Vascular Resistance | 2000 |
Force regulates smooth muscle actin in cardiac fibroblasts.
Topics: Actins; Angiotensin II; Animals; Antihypertensive Agents; Cells, Cultured; Colchicine; Enzyme Inhibitors; Fibroblasts; Gene Expression; Imidazoles; Losartan; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stress, Mechanical; Vasoconstrictor Agents | 2000 |
Pharmacological profile of depressor response elicited by sarthran in rat ventrolateral medulla.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anti-Bacterial Agents; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; GABA Antagonists; Losartan; Male; Medulla Oblongata; Muscimol; Peptides; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Vasoconstrictor Agents | 2000 |
Interaction between angiotensin II and Smad proteins in fibroblasts in failing heart and in vitro.
Topics: Active Transport, Cell Nucleus; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Cardiomegaly; Cell Nucleus; Cells, Cultured; Collagen; Cytosol; DNA-Binding Proteins; Fibroblasts; Heart Failure; In Vitro Techniques; Losartan; Male; Myocardial Infarction; Myocardium; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Smad2 Protein; Smad4 Protein; Trans-Activators; Transforming Growth Factor beta; Vimentin | 2000 |
Acute AT1 receptor blockade does not improve the depressed baroreflex in rats with chronic renal hypertension.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Baroreflex; Bradycardia; Chronic Disease; Heart Rate; Hypertension, Renal; Losartan; Male; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tachycardia | 2000 |
Early diabetes mellitus stimulates proximal tubule renin mRNA expression in the rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Animals; Antihypertensive Agents; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Gene Expression; Hypertrophy; Hypoglycemic Agents; Insulin; Kidney Tubules, Proximal; Losartan; Male; Nephritis, Interstitial; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin; Renin-Angiotensin System; RNA, Messenger | 2000 |
Chronic hypoxia upregulates the expression and function of AT(1) receptor in rat carotid body.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Carotid Body; Chemoreceptor Cells; Chronic Disease; Electrophysiology; Female; Gene Expression Regulation; Hypoxia; Immunohistochemistry; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2000 |
Beneficial effect of combination therapy with an angiotensin II receptor antagonist and angiotensin-converting enzyme inhibitor on overt proteinuria in a patient with type 1 diabetic nephropathy.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Drug Therapy, Combination; Enalapril; Female; Humans; Losartan; Proteinuria | 2000 |
Effect of chronic angiotensin II inhibition on the cardiovascular system of the normal rat.
Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Body Weight; Cardiovascular System; Collagen; Cyclic GMP; DNA; Drinking; Enalapril; Fibrosis; Losartan; Male; Myocardium; NADPH Dehydrogenase; Rats; Rats, Wistar; Reference Values; Systole; Time Factors | 2000 |
Increased AT(1) receptor expression and mRNA in kidney glomeruli of AT(2) receptor gene-disrupted mice.
Topics: Angiotensin II; Animals; Autoradiography; Blood Pressure; Crosses, Genetic; Feedback; Genotype; Imidazoles; Kidney Cortex; Kidney Glomerulus; Kidney Medulla; Losartan; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Organ Specificity; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger; Transcription, Genetic | 2001 |
Mitogen-activated protein kinase activity regulation role of angiotensin and endothelin systems in vascular smooth muscle cells.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Glycopeptides; Losartan; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Pepstatins; Peptides, Cyclic; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Renin | 2001 |
The effects of peptide and nonpeptide angiotensin II-receptor ligands on the activity of brain monoamine oxidase in water-repleted rats.
Topics: Angiotensin II; Animals; Body Water; Brain; Drinking; Imidazoles; Isoenzymes; Ligands; Losartan; Male; Monoamine Oxidase; Peptides; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles | 2000 |
Inhibition of arterial thrombogenesis by quinapril but not losartan.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Dose-Response Relationship, Drug; Isoquinolines; Losartan; Male; Platelet Aggregation; Quinapril; Rats; Rats, Sprague-Dawley; Superoxides; Tetrahydroisoquinolines; Thrombosis | 2000 |
Interaction between paracrine tumor necrosis factor-alpha and paracrine angiotensin II during myocardial ischemia.
Topics: Angiotensin II; Animals; Animals, Newborn; Captopril; Cells, Cultured; Losartan; Male; Myocardial Reperfusion Injury; Paracrine Communication; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2001 |
Hyperoxia/normoxia-driven retinal angiogenesis in mice: a role for angiotensin II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Cell Count; Dextrans; Endothelium; Fluoresceins; Humans; Hyperoxia; Hypoxia; Imidazoles; Infant, Newborn; Losartan; Mice; Mice, Inbred C57BL; Perindopril; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin-Angiotensin System; Retinal Ganglion Cells; Retinal Neovascularization; Retinopathy of Prematurity | 2001 |
Angiotensin II increases calponin expression in cultured rat vascular smooth muscle cells.
Topics: Analysis of Variance; Angiotensin II; Animals; Antihypertensive Agents; Aorta; Calcium-Binding Proteins; Calponins; Cell Differentiation; Cells, Cultured; Drug Interactions; Gene Expression; Losartan; Male; Microfilament Proteins; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2000 |
Central interactions between angiotensin II and PGD(2) in the regulation of vasopressin and oxytocin secretion in dehydrated rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Brain Chemistry; Central Nervous System; Cyclooxygenase Inhibitors; Dehydration; Indomethacin; Injections, Intraventricular; Losartan; Male; Oxytocin; Prostaglandin D2; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents; Vasopressins | 2001 |
Tonic suppression of spontaneous baroreceptor reflex by endogenous angiotensins via AT(2) subtype receptors at nucleus reticularis ventrolateralis in the rat.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin III; Angiotensin Receptor Antagonists; Angiotensins; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Drug Interactions; Functional Laterality; Heart Rate; Imidazoles; Losartan; Male; Medulla Oblongata; Neurons; Pressoreceptors; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reticular Formation; Time Factors | 2001 |
Glucocorticoid modulation of cardiovascular and autonomic function in preterm lambs: role of ANG II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Autonomic Nervous System; Betamethasone; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Female; Gestational Age; Glucocorticoids; Heart Rate; Kidney; Losartan; Pregnancy; Pressoreceptors; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Sheep; Sympathetic Nervous System | 2001 |
Cerebral Na concentration, Na appetite and thirst of sheep: influence of somatostatin and losartan.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Appetite; Brain; Drinking; Female; Hypertonic Solutions; Losartan; Mannitol; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Saline Solution, Hypertonic; Sheep; Sodium; Sodium, Dietary; Somatostatin; Thirst | 2001 |
Effect of oral contraceptives on the renin angiotensin system and renal function.
Topics: Adult; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Blood Pressure; Contraceptives, Oral; Female; Glomerular Filtration Rate; Humans; Inulin; Kidney; Losartan; p-Aminohippuric Acid; Premenopause; Renal Circulation; Renin; Renin-Angiotensin System; Vascular Resistance | 2001 |
A two-state receptor model for the interaction between angiotensin II type 1 receptors and non-peptide antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; CHO Cells; Computer Simulation; Cricetinae; Dose-Response Relationship, Drug; Inositol Phosphates; Irbesartan; Kinetics; Losartan; Models, Biological; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles | 2001 |
Renal and vascular injury induced by exogenous angiotensin II is AT1 receptor-dependent.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Carotid Artery Injuries; Catheterization; Kidney Diseases; Losartan; Male; Peptidyl-Dipeptidase A; Ramipril; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Vasoconstrictor Agents | 2001 |
AT(1) receptor blockers prevent sympathetic hyperactivity and hypertension by chronic ouabain and hypertonic saline.
Topics: Air Movements; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Cardiotonic Agents; Chronic Disease; Guanabenz; Heart Rate; Hypertension; Injections, Intraventricular; Losartan; Male; Ouabain; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Saline Solution, Hypertonic; Stress, Physiological; Sympathetic Nervous System; Vasoconstrictor Agents | 2001 |
Chronic losartan treatment decreases angiotensin II-mediated facilitation of noradrenaline release in the caudal artery of spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Arteries; Blood Pressure; Captopril; Hypertrophy, Left Ventricular; Losartan; Male; Norepinephrine; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Sympathetic Nervous System; Synapses; Vasoconstriction | 2000 |
Zonal differentiation in the rat adrenal cortex.
Topics: Adrenal Cortex; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antigens; Corticosterone; Immunohistochemistry; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Losartan; Membrane Proteins; Potassium; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Repressor Proteins; Time Factors; Tissue Distribution; Zona Fasciculata; Zona Glomerulosa | 2000 |
Losartan and renal sodium handling.
Topics: Angiotensin II; Antihypertensive Agents; Humans; Liver Cirrhosis; Losartan; Natriuresis | 2000 |
Functional expression of angiotensin II receptors in type-I cells of the rat carotid body.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium; Carotid Body; Gene Expression; Imidazoles; Immunohistochemistry; Losartan; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrometry, Fluorescence | 2001 |
Contribution of angiotensin II, endothelin 1 and the endothelium to the slow inotropic response to stretch in ferret papillary muscle.
Topics: Angiotensin II; Animals; Endothelin-1; Endothelium; Female; Ferrets; Kinetics; Losartan; Male; Muscle Spindles; Myocardial Contraction; Octoxynol; Oligopeptides; Papillary Muscles; Peptides, Cyclic; Saralasin | 2001 |
Angiotensin II-induced depolarizations in hamster submandibular ganglion neurons.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Barium; Cricetinae; Electric Impedance; Ganglia, Parasympathetic; Imidazoles; Losartan; Male; Membrane Potentials; Neurons; Neurotransmitter Agents; Potassium Channels; Pyridines; Receptors, Angiotensin; Sodium Channels; Submandibular Gland | 2000 |
Role of angiotensin II in altered baroreflex function of conscious rabbits during late pregnancy.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Female; Fetal Viability; Heart Rate; Litter Size; Logistic Models; Losartan; Nitroprusside; Phenylephrine; Pregnancy; Pregnancy, Animal; Rabbits; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Vasoconstrictor Agents | 2001 |
Angiotensin II relaxes microvessels via the AT(2) receptor and Ca(2+)-activated K(+) (BK(Ca)) channels.
Topics: Angiotensin II; Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin-1; Imidazoles; In Vitro Techniques; Losartan; Male; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Nitroarginine; Patch-Clamp Techniques; Peptides; Potassium Channels; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger; Tetraethylammonium; Vasodilation | 2001 |
Role of endothelin and isoprostanes in slow pressor responses to angiotensin II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Bosentan; Endothelins; Glomerular Filtration Rate; Infusions, Intravenous; Losartan; Nitrites; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Sulfonamides | 2001 |
Angiotensin II induces migration and Pyk2/paxillin phosphorylation of human monocytes.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Arteriosclerosis; Cell Line; Cell Movement; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Enzyme Induction; Enzyme Inhibitors; Humans; Isoenzymes; Losartan; Monocytes; Paxillin; Phosphopeptides; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Signal Transduction; src-Family Kinases | 2001 |
Expression of cell cycle proteins in blood vessels of angiotensin II-infused rats: role of AT(1) receptors.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Blood Vessels; Body Weight; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinases; DNA; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Splanchnic Circulation | 2001 |
Angiotensin II increases vesicular trafficking in brain neurons.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Brain; Dopamine beta-Hydroxylase; Green Fluorescent Proteins; Losartan; Luminescent Proteins; Microscopy, Confocal; Neurites; Neurons; Norepinephrine; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Recombinant Fusion Proteins; Signal Transduction; Transfection | 2001 |
Atypical angiotensin receptors may mediate water intake induced by central injections of angiotensin II and of serotonin in pigeons.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Columbidae; Drinking Behavior; Imidazoles; Injections, Intraventricular; Losartan; Male; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Serotonin | 2001 |
CoenzymeA glutathione disulfide is a potent modulator of angiotensin II-induced vasoconstriction.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Coenzyme A; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Losartan; Male; Perfusion; Rats; Rats, Inbred WKY; Tetrazoles; Time Factors; Vasoconstriction; Vasomotor System | 2001 |
Angiotensin II stimulates cardiac L-type Ca(2+) current by a Ca(2+)- and protein kinase C-dependent mechanism.
Topics: Alkaloids; Angiotensin II; Animals; Benzophenanthridines; Calcium; Calcium Channels, L-Type; Cats; Egtazic Acid; Enzyme Inhibitors; Heart; In Vitro Techniques; Losartan; Membrane Potentials; Myocardium; Naphthalenes; Patch-Clamp Techniques; Phenanthridines; Protein Kinase C | 2001 |
The role of ANG II and endothelin-1 in exercise-induced diastolic dysfunction in heart failure.
Topics: Acetamides; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atrial Function, Left; Diastole; Disease Models, Animal; Dogs; Endothelin Receptor Antagonists; Endothelin-1; Heart Failure; Losartan; Nitroprusside; Physical Exertion; Reference Values; Vasodilation; Ventricular Function, Left | 2001 |
Mechanisms of angiotensin-(1-7)-induced inhibition of angiogenesis.
Topics: Analysis of Variance; Angiogenesis Inhibitors; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Imidazoles; Losartan; Male; Mice; Neovascularization, Pathologic; Neovascularization, Physiologic; Peptide Fragments; Prostheses and Implants; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2 | 2001 |
Brain angiotensin receptors and sympathoadrenal regulation during insulin-induced hypoglycemia.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Glucose; Blood Pressure; Brain; Cerebral Ventricles; Epinephrine; Heart Rate; Hemodynamics; Homeostasis; Hypoglycemia; Imidazoles; Injections, Intraventricular; Insulin; Losartan; Male; Norepinephrine; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reflex | 2001 |
AT1 receptor antagonism enhances angiotensin-II-facilitated carrageenan-induced paw edema.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Carrageenan; Disease Models, Animal; Drug Synergism; Edema; Extremities; Inflammation; Losartan; Male; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Vasoconstrictor Agents | 2000 |
Modulation of the renin-angiotensin system may alter the adrenocortical regeneration.
Topics: Adrenal Cortex; Adrenalectomy; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Calcium Channel Blockers; Cell Division; Enalapril; Losartan; Male; Mitosis; Nifedipine; Rats; Rats, Wistar; Regeneration; Renin; Renin-Angiotensin System; Steroids | 2001 |
Angiotensin converting enzyme (ACE) and non-ACE dependent angiotensin II generation in resistance arteries from patients with heart failure and coronary heart disease.
Topics: Acetylcholine; Aged; Angina Pectoris; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Arteries; Bradykinin; Chymases; Enalaprilat; Female; Heart Failure; Humans; In Vitro Techniques; Losartan; Male; Middle Aged; Oligopeptides; Peptidyl-Dipeptidase A; Serine Endopeptidases; Vascular Resistance; Vasoconstriction | 2001 |
Can angiotensin II receptor blockers be used in patients who have developed a cough or angioedema as a result of taking an ACE inhibitor?
Topics: Acrylates; Angioedema; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Black or African American; Clinical Trials as Topic; Cough; Female; Humans; Imidazoles; Irbesartan; Losartan; Male; Randomized Controlled Trials as Topic; Sex Factors; Telmisartan; Tetrazoles; Thiophenes; Valine; Valsartan | 2001 |
Intracellular Angiotensin II and cell growth of vascular smooth muscle cells.
Topics: Androstadienes; Angiotensin II; Animals; Cell Count; Cell Division; Dose-Response Relationship, Drug; Imidazoles; Liposomes; Losartan; Muscle, Smooth, Vascular; Oligopeptides; Pyridines; Thymidine; Wortmannin | 2001 |
Angiotensin II receptor antagonist blocks the expression of connexin43 induced by cyclical mechanical stretch in cultured neonatal rat cardiac myocytes.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cells, Cultured; Connexin 43; Gene Expression; Heart; Heart Ventricles; Losartan; Physical Stimulation; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger; Signal Transduction | 2001 |
Inhibition of angiotensin II-induced facilitation of sympathetic neurotransmission in the pithed rat: a comparison between losartan, irbesartan, telmisartan, and captopril.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Benzoates; Biphenyl Compounds; Captopril; Decerebrate State; Electric Stimulation; Irbesartan; Losartan; Male; Norepinephrine; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sympathetic Nervous System; Synaptic Transmission; Telmisartan; Tetrazoles | 2001 |
Angiogenesis induced by electrical stimulation is mediated by angiotensin II and VEGF.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Electric Stimulation; Endothelial Growth Factors; Lisinopril; Losartan; Lymphokines; Male; Muscle, Skeletal; Neovascularization, Physiologic; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
AT1 receptor block does not affect arterial baroreflex during pregnancy in rabbits.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Baroreflex; Blood Pressure; Female; Injections, Intravenous; Injections, Intraventricular; Losartan; Pregnancy; Pregnancy, Animal; Rabbits; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Rest; Sympathetic Nervous System; Vasoconstrictor Agents | 2001 |
Angiotensin II AT1 receptors preserve vasodilator reactivity in skeletal muscle resistance arteries.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure Determination; Consciousness; Iloprost; Imidazoles; In Vitro Techniques; Losartan; Male; Microcirculation; Muscle, Skeletal; Muscle, Smooth, Vascular; Oxygen; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin-Angiotensin System; Sodium, Dietary; Vascular Resistance; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2001 |
KT3-671, an angiotensin AT1 receptor antagonist, attenuates vascular but not cardiac responses to sympathetic nerve stimulation in pithed rats.
Topics: Adrenalectomy; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Decerebrate State; Electric Stimulation; Guanethidine; Heart Rate; Imidazoles; Losartan; Male; Norepinephrine; Propranolol; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Spinal Cord; Sympathetic Nervous System; Sympathomimetics; Tetrazoles | 2001 |
Angiotensin receptor in the heart of Bothrops jararaca snake.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin Amide; Angiotensin II; Animals; Binding, Competitive; Bothrops; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Female; Imidazoles; Inositol Phosphates; Losartan; Male; Membranes; Myocardium; Pyridines; Receptors, Angiotensin; Saralasin; Tritium | 2001 |
Angiotensin II type 1 receptor regulation and differential trophic effects on rat cardiac myofibroblasts after acute myocardial infarction.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Becaplermin; Binding, Competitive; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Female; Fibroblasts; Immunohistochemistry; Losartan; Myocardial Infarction; Myocardium; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger | 2001 |
Effects of angiotensin-converting enzyme and angiotensin II on hypoxia-induced proliferation of cultured intra-pulmonary artery smooth muscle cells.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cell Division; Cell Hypoxia; Cells, Cultured; Imidazoles; Losartan; Muscle, Smooth, Vascular; Pulmonary Artery; Pyridines; Rabbits | 2000 |
Systemic infusion of angiotensin II into normal rats activates nuclear factor-kappaB and AP-1 in the kidney: role of AT(1) and AT(2) receptors.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cell Line; Dose-Response Relationship, Drug; Female; Imidazoles; Infusion Pumps; Kidney; Losartan; NF-kappa B; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Time Factors; Transcription Factor AP-1 | 2001 |
Regulation of K+ transport in the rat distal colon via angiotensin II subtype receptors and K+ -pathways.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biological Transport, Active; Carrier Proteins; Colon; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Losartan; Male; Potassium; Potassium Channels; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase | 2001 |
Central AT1 and AT2 receptors mediate chronic intracerebroventricular angiotensin II-induced drinking in rats fed high sodium chloride diet from weaning.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Brain; Dose-Response Relationship, Drug; Drinking; Drug Interactions; Imidazoles; Injections, Intraventricular; Losartan; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Sodium, Dietary | 2001 |
Effect of angiotensin II on calcium reabsorption by the luminal membranes of the nephron.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biological Transport; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Imidazoles; Kidney Tubules, Proximal; Losartan; Nephrons; Nitrendipine; Parathyroid Hormone; Pyridines; Rabbits; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Second Messenger Systems; Sodium; Thionucleotides; Vasoconstrictor Agents | 2001 |
Chronotropic effect of angiotensin II via type 2 receptors in rat brain neurons.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Action Potentials; Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Arachidonic Acids; Brain; Cytarabine; Enzyme Inhibitors; Imidazoles; Lipoxygenase; Lipoxygenase Inhibitors; Losartan; Nerve Tissue Proteins; Neurons; Okadaic Acid; Phosphoprotein Phosphatases; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Signal Transduction; Synaptic Transmission; Tetrodotoxin; Time Factors | 2001 |
Glucocorticoids potentiate central actions of angiotensin to increase arterial pressure.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Brain; Corticosterone; Drug Synergism; Imidazoles; Injections, Intravenous; Injections, Intraventricular; Losartan; Male; Microinjections; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Reference Values; Tetrazoles | 2001 |
Angiotensin II activates nuclear transcription factor-kappaB in aorta of normal rats and in vascular smooth muscle cells of AT1 knockout mice.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Base Sequence; Binding Sites; Cells, Cultured; Consensus Sequence; Endothelium, Vascular; Gene Expression Regulation; Imidazoles; Losartan; Mice; Mice, Knockout; Models, Biological; Muscle, Smooth, Vascular; NF-kappa B; Pyridines; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Transcription Factors | 2001 |
Endothelial and myocyte apoptosis--role of angiotensin II.
Topics: Angiotensin II; Apoptosis; Endothelium, Vascular; Humans; Hypertension; In Vitro Techniques; Losartan; Muscle, Smooth; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 2001 |
Regulation of angiotensin II-stimulated osteopontin expression in cardiac microvascular endothelial cells: role of p42/44 mitogen-activated protein kinase and reactive oxygen species.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Angiotensin II; Animals; Antihypertensive Agents; Blotting, Northern; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Indicators and Reagents; Losartan; Male; Membrane Transport Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NADPH Dehydrogenase; NADPH Oxidases; Onium Compounds; Osteopontin; Phosphoproteins; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sialoglycoproteins; Vasoconstrictor Agents | 2001 |
Differential effects of eprosartan and losartan at prejunctional angiotensin II receptors.
Topics: Acrylates; Angiotensin II; Animals; Antihypertensive Agents; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Female; Heart Ventricles; Imidazoles; Losartan; Male; Presynaptic Terminals; Pulmonary Artery; Rats; Rats, Wistar; Receptors, Angiotensin; Thiophenes; Vasoconstrictor Agents; Ventricular Function | 2001 |
Attenuation of tissue P-selectin and MCP-1 expression and intimal proliferation by AT(1) receptor blockade in hyperlipidemic rabbits.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Arteriosclerosis; Chemokine CCL2; Diet, Atherogenic; Hyperlipidemias; Losartan; Male; P-Selectin; Rabbits; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2 | 2001 |
Synthesis and study of a cyclic angiotensin II antagonist analogue reveals the role of pi*--pi* interactions in the C-terminal aromatic residue for agonist activity and its structure resemblance with AT(1) non-peptide antagonists.
Topics: Acrylates; Angiotensin II; Animals; Antihypertensive Agents; Biochemistry; Biphenyl Compounds; Drug Design; Imidazoles; Irbesartan; Losartan; Magnetic Resonance Spectroscopy; Male; Models, Molecular; Peptides, Cyclic; Rabbits; Structure-Activity Relationship; Tetrazoles; Thiophenes | 2001 |
Role of brain angiotensin II on somatosensory-induced antinatriuresis in hypertensive rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Brain; Capsaicin; Diuresis; Hypertension; Kidney; Losartan; Male; Natriuresis; Neural Pathways; Rats; Rats, Inbred SHR; Rats, Wistar; Renal Circulation; Sodium; Somatosensory Cortex; Sympathetic Nervous System | 2001 |
Neural mechanisms subserving central angiotensinergic influences on plasma renin in sheep.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cerebral Ventricles; Denervation; Female; Hypothalamus; Infusions, Parenteral; Kidney; Losartan; Median Eminence; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin; Sheep; Sodium; Vasopressins | 2001 |
Intracellular angiotensin II elicits Ca2+ increases in A7r5 vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Calcium; Cell Line; Cell Membrane Permeability; Dose-Response Relationship, Drug; Imidazoles; Inositol 1,4,5-Trisphosphate; Liposomes; Losartan; Muscle, Smooth, Vascular; Peptidyl-Dipeptidase A; Potassium Chloride; Pyridines | 2001 |
Biomechanical strain induces class a scavenger receptor expression in human monocyte/macrophages and THP-1 cells: a potential mechanism of increased atherosclerosis in hypertension.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Apolipoproteins E; Arteriosclerosis; CD36 Antigens; Cell Adhesion; Cell Differentiation; Cells, Cultured; Cholesterol, Dietary; Disease Models, Animal; Humans; Hypertension; Immunohistochemistry; Losartan; Macrophages; Male; Membrane Proteins; Mice; Mice, Knockout; Monocytes; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Cytoplasmic and Nuclear; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, Scavenger; RNA, Messenger; Scavenger Receptors, Class A; Scavenger Receptors, Class B; Stress, Mechanical; Tetradecanoylphorbol Acetate; Transcription Factors | 2001 |
Effects of angiotensin II and the AT(1) receptor antagonist losartan on the renal excretion of urodilatin.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atrial Natriuretic Factor; Endothelin-1; Glomerular Filtration Rate; Kidney; Losartan; Male; Peptide Fragments; Perfusion; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renal Circulation; Sodium; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents | 2001 |
Effect of the AT1-receptor antagonists losartan, irbesartan, and telmisartan on angiotensin II-induced facilitation of sympathetic neurotransmission in the rat mesenteric artery.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Dose-Response Relationship, Drug; Electric Stimulation; Irbesartan; Losartan; Male; Mesenteric Arteries; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Sympathetic Nervous System; Telmisartan; Tetrazoles; Vasoconstrictor Agents | 2001 |
Relative efficacy of an angiotensin II antagonist compared with other antihypertensive agents. Olmesartan medoxomil versus antihypertensives.
Topics: Angiotensin II; Antihypertensive Agents; Atenolol; Captopril; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hypertension; Imidazoles; Losartan; Multicenter Studies as Topic; Olmesartan Medoxomil; Randomized Controlled Trials as Topic; Tetrazoles | 2001 |
Angiotensin II AT(2) receptors inhibit growth responses in proximal tubule cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Apoptosis; Calcium; Cell Division; Cell Line; DNA; Epidermal Growth Factor; Imidazoles; Immunoblotting; Kidney Tubules, Proximal; Losartan; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Protein Tyrosine Phosphatases; Pyridines; Radioligand Assay; Receptors, Angiotensin; Transfection; Vanadates | 2001 |
Different types of antagonism by losartan and irbesartan on the effects of angiotensin II and its degradation products in rabbit arteries.
Topics: Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Anti-Bacterial Agents; Antihypertensive Agents; Biphenyl Compounds; Endothelium, Vascular; Femoral Artery; Imidazoles; In Vitro Techniques; Irbesartan; Leucine; Losartan; Male; Peptides; Protease Inhibitors; Pyridines; Rabbits; Receptor, Angiotensin, Type 1; Renal Artery; Tetrazoles; Vasoconstrictor Agents | 2001 |
Impaired angiotensin II regulation of renal C-type natriuretic peptide mRNA expression in experimental diabetes mellitus.
Topics: Angiotensin II; Animals; Blotting, Northern; Diabetes Mellitus, Experimental; Gene Expression Regulation; Kidney Cortex; Losartan; Male; Natriuretic Peptide, C-Type; Ramipril; Rats; Rats, Wistar; Renin-Angiotensin System; RNA, Messenger | 2001 |
Fetal toxic effects and angiotensin-II-receptor antagonists.
Topics: Abnormalities, Drug-Induced; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Female; Humans; Hypertension; Losartan; Pregnancy; Pregnancy Complications, Cardiovascular; Tetrazoles; Valine; Valsartan | 2001 |
Tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells: the role of MAPKs after angiotensin II stimulation.
Topics: Adrenal Glands; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anisomycin; Antihypertensive Agents; Butadienes; Cattle; Chromaffin Cells; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Flavonoids; Imidazoles; Immunoblotting; Losartan; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Phosphoserine; Protein Synthesis Inhibitors; Pyridines; Receptors, Angiotensin; Time Factors; Tyrosine 3-Monooxygenase | 2001 |
Angiotensin-induced enhancement of excitatory junction potentials evoked by periarteriolar nerve stimulation and vasoconstriction in rat mesenteric arteries are both mediated by the angiotensin AT1 receptor.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Arterioles; Electric Stimulation; Excitatory Postsynaptic Potentials; Losartan; Male; Mesenteric Arteries; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Sympathetic Nervous System; Vasoconstriction; Vasoconstrictor Agents | 2001 |
Angiotensin IV enhances LTP in rat dentate gyrus in vivo.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Dentate Gyrus; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Long-Term Potentiation; Losartan; Male; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Synaptic Transmission; Time Factors | 2001 |
Angiotensin II and VEGF are involved in angiogenesis induced by short-term exercise training.
Topics: Angiotensin II; Animals; Antibodies; Antihypertensive Agents; Blood Pressure; Blotting, Western; Body Composition; Body Weight; Captopril; Cell Count; Densitometry; Endothelial Growth Factors; Losartan; Lymphokines; Male; Microcirculation; Muscle, Skeletal; Neovascularization, Physiologic; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
ANG II in median preoptic nucleus and pressor responses to CSF sodium and high sodium intake in SHR.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Drug Interactions; Enzyme Inhibitors; Heart Rate; Injections, Intraventricular; Losartan; Male; Microinjections; Ouabain; Preoptic Area; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Saline Solution, Hypertonic; Sodium; Sodium, Dietary | 2001 |
Cardioprotective effects of ramipril and losartan in right ventricular pressure overload in the rabbit: importance of kinins and influence on angiotensin II type 1 receptor signaling pathway.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; GTP-Binding Proteins; Hemodynamics; In Vitro Techniques; Kinins; Losartan; Male; Myocardial Contraction; Myocardium; Organ Size; Papillary Muscles; Protein Subunits; Pulmonary Artery; Rabbits; Ramipril; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Signal Transduction; Ventricular Dysfunction, Right | 2001 |
Effect of chronic angiotensin II inhibition on the nitric oxide synthase in the normal rat during aging.
Topics: Aging; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Cardiomegaly; Enalapril; Losartan; Male; NADPH Dehydrogenase; Nitrates; Nitric Oxide Synthase; Nitrites; Rats; Rats, Wistar; Reference Values; Time Factors | 2001 |
Differential regulation of thrombospondin-1 and fibronectin by angiotensin II receptor subtypes in cultured endothelial cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Arteriosclerosis; Blotting, Northern; Cattle; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Endothelium, Vascular; Fibronectins; Imidazoles; Losartan; Male; Oligopeptides; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thrombospondin 1 | 2001 |
Influence of the renin-angiotensin system on epidermal growth factor expression in normal and cyclosporine-treated rat kidney.
Topics: Angiotensin II; Animals; Apoptosis; Blood Pressure; Cyclosporine; Diet, Sodium-Restricted; Epidermal Growth Factor; Fibrosis; Immunohistochemistry; In Situ Nick-End Labeling; Kidney Glomerulus; Losartan; Male; Rats; Rats, Sprague-Dawley; Renin; Renin-Angiotensin System | 2001 |
Angiotensin II administration to atherosclerotic mice increases macrophage uptake of oxidized ldl: a possible role for interleukin-6.
Topics: Angiotensin II; Animals; Antibodies; Apolipoproteins E; Arteriosclerosis; CD36 Antigens; Cells, Cultured; Dose-Response Relationship, Drug; Foam Cells; Injections; Interleukin-6; Lipoproteins, LDL; Losartan; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Knockout; Receptors, Interleukin-6; RNA, Messenger | 2001 |
Role of angiotensin II and free radicals in blood pressure regulation in a rat model of renal hypertension.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Blood Pressure; Blotting, Western; Cyclic N-Oxides; Disease Models, Animal; Free Radical Scavengers; Free Radicals; Hypertension, Renovascular; Losartan; Male; Nephrectomy; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renal Artery; Renin; Spin Labels; Superoxides; Systole; Time Factors; Tyrosine | 2001 |
Angiotensin II type AT(2) receptor mRNA expression and renal vasodilatation are increased in renal failure.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Angiotensin II; Animals; Antihypertensive Agents; Arachidonic Acid; Clotrimazole; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Gene Expression Regulation; Imidazoles; In Vitro Techniques; Indomethacin; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Oligopeptides; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renal Insufficiency; RNA, Messenger; Vasodilation | 2001 |
Renal vascular effects of frusemide in the rat: influence of salt loading and the role of angiotensin II.
Topics: Analysis of Variance; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biological Transport; Captopril; Diuretics; Furosemide; Kidney; Kidney Tubules; Laser-Doppler Flowmetry; Losartan; Male; Rats; Rats, Wistar; Renal Circulation; Sodium; Sodium Chloride; Time Factors; Urination; Vasoconstriction | 2001 |
Angiotensin II enhances noradrenaline release from sympathetic nerves of the rat prostate via a novel angiotensin receptor: implications for the pathophysiology of benign prostatic hyperplasia.
Topics: Analysis of Variance; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Captopril; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Imidazoles; Losartan; Male; Norepinephrine; Oligopeptides; Prostate; Prostatic Hyperplasia; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Sympathetic Nervous System; Synaptic Transmission | 2001 |
Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death.
Topics: Angiotensin II; Animals; Apoptosis; Cells, Cultured; DNA; Gene Expression Regulation; Glycosylation; Heart Ventricles; Hydrogen-Ion Concentration; Hyperglycemia; JNK Mitogen-Activated Protein Kinases; Losartan; Male; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Sprague-Dawley; Tumor Suppressor Protein p53 | 2001 |
Interaction between sodium intake, angiotensin II, and blood pressure as a cause of cardiac hypertrophy.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Cardiomegaly; Circadian Rhythm; Cross-Over Studies; Disease Models, Animal; France; Heart; Hypertension, Renovascular; Kidney; Losartan; Models, Cardiovascular; Organ Size; Rats; Rats, Wistar; Renin; Sodium, Dietary; Telemetry | 2001 |
Increased AT(1) receptors in adrenal gland of AT(2) receptor gene-disrupted mice.
Topics: Adrenal Medulla; Angiotensin II; Animals; Autoradiography; Blood Pressure; Female; Gene Expression Regulation; Genotype; Imidazoles; In Situ Hybridization; Losartan; Mice; Mice, Inbred Strains; Mice, Knockout; Mice, Mutant Strains; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger; Transcription, Genetic; Vasoconstrictor Agents; Zona Glomerulosa | 2001 |
Losartan inhibits the angiotensin II-induced modifications on fibrinolysis and matrix deposition by primary human vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Cells, Cultured; DNA; Extracellular Matrix; Fibrinolysis; Glycosaminoglycans; Humans; Losartan; Matrix Metalloproteinase 2; Muscle, Smooth, Vascular; Plasminogen Activator Inhibitor 1; Pulmonary Artery; Receptor, Angiotensin, Type 1; Thymidine; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Tissue Plasminogen Activator; Tritium | 2001 |
Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Arteriosclerosis; Drug Synergism; Female; Imidazoles; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyridines; Severity of Illness Index | 2001 |
Angiotensins II and IV stimulate the rat adrenocortical cell proliferation acting via different receptors.
Topics: Adrenal Cortex; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cell Division; Losartan; Male; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Angiotensin | 2001 |
Effects of losartan on blood pressure and humoral factors in a patient who suffered from anaphylactoid reactions when treated with ACE inhibitors during LDL apheresis.
Topics: Aldosterone; Anaphylaxis; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Component Removal; Blood Pressure; Bradykinin; Cholesterol, LDL; Humans; Hypotension; Losartan; Male; Middle Aged; Oligopeptides; Receptor, Angiotensin, Type 1; Renin | 2001 |
Effects of combined administration of ACE inhibitor and angiotensin II receptor antagonist are prevented by a high NaCl intake.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Behavior, Animal; Blood; Blood Pressure; Body Weight; Diet, Sodium-Restricted; Drug Synergism; Eating; Heart; Losartan; Organ Size; Perindopril; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Renin-Angiotensin System | 2001 |
Angiotensin II inhibits insulin-stimulated phosphorylation of eukaryotic initiation factor 4E-binding protein-1 in proximal tubular epithelial cells.
Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Carrier Proteins; Cell Cycle Proteins; Cells, Cultured; Dimerization; Eukaryotic Initiation Factors; Immunoblotting; Insulin; Losartan; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Binding; Signal Transduction | 2001 |
Peripheral administration of AT1 receptor blockers and pressor responses to central angiotensin II and sodium.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Dihydropyridines; Dose-Response Relationship, Drug; Heart Rate; Injections, Intravenous; Injections, Intraventricular; Losartan; Male; Peripheral Nervous System; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Sodium; Tetrazoles | 2001 |
Renal protection by angiotensin II receptor antagonists in patients with type 2 diabetes.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Hypertension, Renal; Irbesartan; Kidney; Losartan; Male; Primary Prevention; Prognosis; Tetrazoles; Treatment Outcome | 2001 |
Isoproterenol-induced cardiac hypertrophy: role of circulatory versus cardiac renin-angiotensin system.
Topics: Adrenergic beta-Agonists; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Collagen; Coronary Circulation; Heart Rate; Isoproterenol; Isoquinolines; Losartan; Male; Myocardium; Organ Size; Peptidyl-Dipeptidase A; Quinapril; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Renin; Renin-Angiotensin System; Tetrahydroisoquinolines | 2001 |
Angiotensin II inhibits and alters kinetics of voltage-gated K(+) channels of rat arterial smooth muscle.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diglycerides; Enzyme Inhibitors; Isoenzymes; Kinetics; Losartan; Male; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Peptides; Potassium Channels, Voltage-Gated; Protein Kinase C; Protein Kinase C-epsilon; Rats; Rats, Wistar; Thionucleotides; Vasoconstrictor Agents | 2001 |
Blockade of angiotensin receptor subtypes in arcuate uterine artery of pregnant and postpartum rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arteries; Culture Techniques; Dose-Response Relationship, Drug; Drug Interactions; Female; Imidazoles; Losartan; Postpartum Period; Pregnancy; Pregnancy, Animal; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Uterus; Vasoconstriction; Vasoconstrictor Agents | 2001 |
Angiotensin II via activation of type 1 receptor upregulates expression of endoglin in human coronary artery endothelial cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antigens, CD; Cells, Cultured; Coronary Vessels; Endoglin; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Humans; Losartan; Mitogen-Activated Protein Kinases; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Receptors, Cell Surface; Receptors, Transforming Growth Factor beta; RNA, Messenger; Transcriptional Activation; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 2001 |
AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Brain Neoplasms; Cell Division; Glioma; Losartan; Neovascularization, Pathologic; Rats; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Tumor Cells, Cultured | 2001 |
Constitutive internalization of constitutively active agiotensin II AT(1A) receptor mutants is blocked by inverse agonists.
Topics: Amino Acid Substitution; Angiotensin II; Biological Transport; Cell Line; Endocytosis; Green Fluorescent Proteins; Humans; Kinetics; Ligands; Losartan; Luminescent Proteins; Microscopy, Confocal; Models, Biological; Monensin; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Recombinant Fusion Proteins; Transfection | 2002 |
Regulation of vascular proteoglycan synthesis by angiotensin II type 1 and type 2 receptors.
Topics: Aggrecans; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cells, Cultured; DNA, Complementary; Extracellular Matrix Proteins; Glycoproteins; Heparan Sulfate Proteoglycans; Imidazoles; Lectins, C-Type; Losartan; Male; Muscle, Smooth, Vascular; Proteoglycans; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger | 2001 |
Angiotensin-(1-7) reverts the stimulatory effect of angiotensin II on the proximal tubule Na(+)-ATPase activity via a A779-sensitive receptor.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Cell Membrane; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Kidney Tubules, Proximal; Losartan; Peptide Fragments; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Saralasin; Sodium-Potassium-Exchanging ATPase; Swine | 2002 |
Endogenous angiotensin modulates PGE(2)-mediated release of substance P from renal mechanosensory nerve fibers.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Dinoprostone; In Vitro Techniques; Kidney; Losartan; Male; Mechanoreceptors; Nerve Fibers; Neurons, Afferent; Pressure; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Sodium, Dietary; Substance P; Vasoconstrictor Agents | 2002 |
Chronic hypotensive effects of losartan are not dependent on the actions of angiotensin II at AT 2 receptors.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Sodium Chloride, Dietary; Water-Electrolyte Balance | 2002 |
Diverse effects of chronic treatment with losartan, fosinopril, and amlodipine on apoptosis, angiotensin II in the left ventricle of hypertensive rats.
Topics: Amlodipine; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Apoptosis; Blood Pressure; China; Disease Models, Animal; Fosinopril; Heart Ventricles; Hypertrophy, Left Ventricular; Losartan; Models, Cardiovascular; Myocardium; Random Allocation; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1 | 2001 |
Angiotensin II promotes the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser133 through an ERK1/2-dependent mechanism.
Topics: Adrenal Medulla; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzylamines; Butadienes; Cattle; Cells, Cultured; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Isoquinolines; Losartan; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Phosphoserine; Protein Processing, Post-Translational; Proto-Oncogene Proteins pp60(c-src); Pyridines; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Ribosomal Protein S6 Kinases; src-Family Kinases; Sulfonamides | 2001 |
[The role of AT1 receptor and cyclin kinase inhibitor p27 protein in angiotensin II-induced hypertrophy of mesangial cell].
Topics: Angiotensin II; Animals; Antihypertensive Agents; Cell Cycle Proteins; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p27; Glomerular Mesangium; Hypertrophy; Losartan; Oligodeoxyribonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Tumor Suppressor Proteins | 2001 |
Differential effect of angiotensin II on blood circulation in the renal medulla and cortex of anaesthetised rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Imidazoles; Kidney Cortex; Kidney Medulla; Losartan; Male; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renal Circulation; Saralasin; Vasoconstrictor Agents | 2002 |
Effect of combining an ACE inhibitor and an angiotensin II receptor blocker on plasma and kidney tissue angiotensin II levels.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Kidney; Losartan; Male; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Sodium, Dietary | 2002 |
Angiotensin II type 1 receptor modulation of L-type calcium currents in guinea-pig ventricular cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Heart Ventricles; Losartan; Membrane Potentials; Patch-Clamp Techniques; Protein Kinase C; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Ventricular Function | 2001 |
The expression of AT1 receptor on hepatic stellate cells in rat fibrosis induced by CCl4.
Topics: Alanine Transaminase; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cells, Cultured; Enalapril; Fibrosis; Immunohistochemistry; Liver; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Renin-Angiotensin System | 2001 |
Angiotensin AT(1) receptor signalling modulates reparative angiogenesis induced by limb ischaemia.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Extremities; Femoral Artery; Gene Expression; Ischemia; Losartan; Male; Mice; Neovascularization, Physiologic; Peptidyl-Dipeptidase A; Ramipril; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Angiotensin; Receptors, Bradykinin; Renin-Angiotensin System; RNA, Messenger; Signal Transduction | 2002 |
Intracellular angiotensin II inhibits heterologous receptor stimulated Ca2+ entry.
Topics: Angiotensin II; Animals; Calcium; Cell Line; Imidazoles; Liposomes; Losartan; Muscle, Smooth; Pyridines; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Serotonin; Uridine Triphosphate | 2001 |
Angiotensin II stimulates migration of retinal microvascular pericytes: involvement of TGF-beta and PDGF-BB.
Topics: Angiotensin II; Animals; Antibodies; Anticoagulants; Antihypertensive Agents; Becaplermin; Cattle; Cells, Cultured; Chemotaxis; Dipeptides; Endothelial Growth Factors; Imidazoles; Losartan; Lymphokines; Matrix Metalloproteinase 2; Microcirculation; Neovascularization, Physiologic; Pericytes; Platelet-Derived Growth Factor; Protease Inhibitors; Proto-Oncogene Proteins c-sis; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin-Angiotensin System; Retina; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vasoconstrictor Agents | 2002 |
The mechanism of angiotensin II binding downregulation by high glucose in primary renal proximal tubule cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Calcium Channel Blockers; Carcinogens; Cells, Cultured; Dose-Response Relationship, Drug; Gene Expression; Glucose; Imidazoles; Iodine Radioisotopes; Kidney Tubules, Proximal; Lipid Peroxidation; Losartan; Nifedipine; Oxidants; Oxidative Stress; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Rabbits; Radioligand Assay; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Vasoconstrictor Agents | 2002 |
Angiotensin II regulates oxygen consumption.
Topics: Adipose Tissue; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Drinking; Eating; Energy Metabolism; Losartan; Male; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Vasoconstrictor Agents | 2002 |
Effects of long-term enalapril and losartan therapy of hypertension on cardiovascular aldosterone.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Cardiovascular System; Drug Administration Schedule; Enalapril; Hypertension; Losartan; Mesenteric Arteries; Myocardium; Rats; Rats, Inbred SHR; Rats, Wistar; Receptor, Angiotensin, Type 1; Reference Values | 2001 |
Use of angiotensin-converting enzyme inhibitors in patients with diabetes and coronary artery disease.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Bradykinin; Chymases; Coronary Artery Disease; Diabetic Angiopathies; Endothelium, Vascular; Fibrinolysis; Humans; Losartan; Oxidative Stress; Serine Endopeptidases | 2002 |
[Angiotensin II receptor antagonists reduce the development of nephropathies in type 2 diabetes. Three new studies are of interest, but don't answer all questions].
Topics: Angiotensin II; Antihypertensive Agents; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Follow-Up Studies; Humans; Losartan; Randomized Controlled Trials as Topic | 2001 |
Angiotensin II reduces macrophage cholesterol efflux: a role for the AT-1 receptor but not for the ABC1 transporter.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Biological Transport; Cell Membrane; Cholesterol; Cholesterol, HDL; Cytosol; Glycoproteins; Humans; Losartan; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; RNA, Messenger; Vasoconstrictor Agents | 2002 |
Enhanced ammonia secretion by proximal tubules from mice receiving NH(4)Cl: role of angiotensin II.
Topics: Acid-Base Equilibrium; Acids; Amiloride; Ammonia; Ammonium Chloride; Angiotensin II; Animals; Antihypertensive Agents; Carbon Dioxide; Diuretics; Kidney Tubules, Proximal; Losartan; Male; Mice; Microcirculation; Potassium; Renal Circulation; Vasoconstrictor Agents | 2002 |
AT(2) but not AT(1) receptor antagonism abolishes angiotensin II increase of the acquisition of conditioned avoidance responses in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Avoidance Learning; Cognition; Conditioning, Operant; Exploratory Behavior; Imidazoles; Injections, Intraventricular; Losartan; Male; Mental Recall; Motor Activity; Psychomotor Performance; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2 | 2002 |
Effects of antihypertensive therapy on intrarenal angiotensin and bradykinin levels in experimental renal insufficiency.
Topics: Aldosterone; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Bradykinin; Creatinine; Enalapril; Kidney; Losartan; Male; Nephrectomy; Nifedipine; Proteinuria; Rats; Rats, Wistar; Renin; Renin-Angiotensin System; Vasodilator Agents | 2002 |
Influence of losartan and enalapril on urinary excretion of 8-isoprostane in experimental nephrotic syndrome.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Dinoprost; Enalapril; F2-Isoprostanes; Losartan; Nephrotic Syndrome; Rats | 2002 |
Modulation of matrix metalloproteinase-1, its tissue inhibitor, and nuclear factor-kappa B by losartan in hypercholesterolemic rabbits.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Abdominal; Arteriosclerosis; Blotting, Western; Cholesterol; Diet, Atherogenic; Gene Expression Regulation; Hypercholesterolemia; Immunohistochemistry; Losartan; Male; Matrix Metalloproteinase 1; NF-kappa B; Rabbits; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-2; Tunica Intima; Tunica Media | 2002 |
Angiotensin receptor subtype AT(1) mediates alveolar epithelial cell apoptosis in response to ANG II.
Topics: Adenocarcinoma; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Apoptosis; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Imidazoles; Losartan; Lung Neoplasms; Pulmonary Alveoli; Pulmonary Fibrosis; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Respiratory Mucosa; Tetrazoles; Tumor Cells, Cultured; Vasoconstrictor Agents | 2002 |
Losartan reduces collagen content and intimal thickening of iliac arteries after balloon injury in rabbits.
Topics: Angiotensin II; Animals; Catheterization; Collagen; Iliac Artery; Losartan; Male; Rabbits; Tunica Intima; Tunica Media; Wounds, Nonpenetrating | 2000 |
Effects of different durations of pretreatment with losartan on myocardial infarct size, endothelial function, and vascular endothelial growth factor.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Disease Models, Animal; Endothelial Growth Factors; Endothelium, Vascular; Female; Losartan; Lymphokines; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Sprague-Dawley; Renin; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vasodilation | 2001 |
Influence of estrogen and/or progesterone on isolated ovariectomized rat uterus. Responsiveness to Ang II.
Topics: Angiotensin II; Animals; Dose-Response Relationship, Drug; Estrogens; Female; Imidazoles; In Vitro Techniques; Losartan; Muscle Contraction; Ovariectomy; Progesterone; Pyridines; Rats; Rats, Wistar; Uterus | 2002 |
Dysregulation of angiotensin II synthesis is associated with salt sensitivity in the spontaneous hypertensive rat.
Topics: Aldosterone; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Blood Pressure; Hypertension; Losartan; Male; Peptidyl-Dipeptidase A; Rats; Rats, Inbred SHR; Receptors, Angiotensin; Renin; Sodium Chloride, Dietary | 2002 |
Brain-selective overexpression of angiotensin (AT1) receptors causes enhanced cardiovascular sensitivity in transgenic mice.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Brain; Cardiovascular Physiological Phenomena; Immunohistochemistry; Injections, Intraventricular; Losartan; Mice; Mice, Transgenic; Models, Animal; Neurons; Organ Specificity; Phosphopyruvate Hydratase; Rats; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Recombinant Fusion Proteins; Transgenes | 2002 |
Losartan attenuates endothelial hyperpermeability responses to VPF and high glucose but not angiotensin II.
Topics: Angiotensin II; Antihypertensive Agents; Cells, Cultured; Endothelial Growth Factors; Endothelium, Vascular; Glucose; Humans; Losartan; Lymphokines; Pulmonary Artery; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
Effect of AT(1) receptor blockade on cardiac apoptosis in angiotensin II-induced hypertension.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Caspases; Echocardiography; Hypertension; In Situ Nick-End Labeling; Losartan; Male; Myocardium; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Signal Transduction | 2002 |
Angiotensin II directly stimulates ENaC activity in the cortical collecting duct via AT(1) receptors.
Topics: Amiloride; Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Benzofurans; Biphenyl Compounds; Hydrogen-Ion Concentration; Intracellular Membranes; Ionophores; Kidney Tubules, Collecting; Losartan; Mice; Microscopy, Fluorescence; Monensin; Rabbits; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Signal Transduction; Sodium Chloride; Tetrazoles | 2002 |
Effects of high glucose on interleukin-6 production in human mesangial cells.
Topics: Angiotensin II; Captopril; Cells, Cultured; Gene Expression; Glomerular Mesangium; Glucose; Humans; Interleukin-6; Losartan | 2002 |
Mechanical strain-induced human vascular matrix synthesis: the role of angiotensin II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Cells, Cultured; Extracellular Matrix; Extracellular Matrix Proteins; Gene Expression; Humans; Losartan; Muscle, Smooth, Vascular; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Stress, Mechanical | 2000 |
Angiotensin II does not mediate the pressor response to PGD2 (icv).
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cyclooxygenase Inhibitors; Indomethacin; Injections, Intraventricular; Losartan; Male; Prostaglandin D2; Rats; Rats, Sprague-Dawley | 2000 |
The effect of angiotensin II on mitogen-activated protein kinase in human cardiomyocytes.
Topics: Aged; Angiotensin II; Angiotensin Receptor Antagonists; Culture Techniques; Drug Synergism; Enzyme Activation; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Losartan; Middle Aged; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2 | 2000 |
Effects of angiotensin II microinjected into medial amygdala on male sexual behavior in rats.
Topics: Amygdala; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Losartan; Male; Microinjections; Oligopeptides; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sexual Behavior, Animal; Vasoconstrictor Agents | 2002 |
Inhibition of vascular smooth muscle cell growth by angiotensin type 2 receptor stimulation for in vitro organ culture model.
Topics: Angiogenesis Inhibitors; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Cell Division; Cells, Cultured; Losartan; Male; Muscle, Smooth, Vascular; Organ Culture Techniques; Rats; Receptors, Angiotensin; Vasoconstrictor Agents | 2002 |
Effect of 1-week losartan administration on bile duct-ligated cirrhotic rats with portal hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blotting, Western; Common Bile Duct; Enzyme Inhibitors; Hematocrit; Hypertension, Portal; Ligation; Liver Circulation; Liver Cirrhosis; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Norepinephrine; Plasma Volume; Rats; Rats, Sprague-Dawley; Renin | 2002 |
Angiotensin II inhibits human trophoblast invasion through AT1 receptor activation.
Topics: Angiotensin II; Calcineurin; Cell Line; Cyclosporine; DNA-Binding Proteins; Embryo Implantation; Gene Expression Regulation; Humans; Losartan; NFATC Transcription Factors; Nuclear Proteins; Plasminogen Activator Inhibitor 1; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; RNA, Messenger; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Trophoblasts | 2002 |
The renin-angiotensin system does not contribute to the endothelial dysfunction and increased infarct size in rats exposed to second hand smoke.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Electrocardiography; Endothelial Growth Factors; Endothelium, Vascular; Female; Hemodynamics; Losartan; Lymphokines; Muscle, Smooth, Vascular; Myocardial Infarction; Nicotine; Rats; Rats, Sprague-Dawley; Refractory Period, Electrophysiological; Renin; Renin-Angiotensin System; Reperfusion Injury; Tobacco Smoke Pollution; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Ventricular Fibrillation | 2002 |
Angiotensin II supports sympathetically mediated vasopressor response to footshock-stress.
Topics: Analysis of Variance; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Cardiovascular Physiological Phenomena; Catecholamines; Electroshock; Heart Rate; Losartan; Male; Nephrectomy; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Sympathetic Nervous System | 2002 |
Angiotensin II stimulates synthesis of vascular smooth muscle cell proteoglycans with enhanced low density lipoprotein binding properties.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Aorta, Thoracic; Blotting, Northern; Cell Division; Chromatography, Affinity; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Humans; Lipoproteins, LDL; Losartan; Muscle, Smooth, Vascular; Protein-Tyrosine Kinases; Proteoglycans; Receptor, Angiotensin, Type 1; Signal Transduction | 2002 |
Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism.
Topics: Administration, Oral; Allopurinol; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arterioles; Benzofurans; Blood Pressure; Diuretics; Enalapril; Hydrochlorothiazide; Hypertension; Kidney; Losartan; Male; Muscle, Smooth, Vascular; Oxonic Acid; Rats; Rats, Sprague-Dawley; Sodium Chloride Symporter Inhibitors; Sodium Chloride, Dietary; Uric Acid; Uricosuric Agents; Vascular Diseases | 2002 |
Comparison of angiotensin II (Ang II) effects in the internal anal sphincter (IAS) and lower esophageal sphincter smooth muscles.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anal Canal; Angiotensin II; Animals; Dose-Response Relationship, Drug; Drug Combinations; Esophagus; Female; Flavonoids; Genistein; Imidazoles; Losartan; Male; Muscle Contraction; Muscle, Smooth; Nicardipine; Opossums; Pyridines; Rabbits; Species Specificity; Tyrphostins | 2002 |
Microinjection of ANG II into paraventricular nucleus enhances cardiac sympathetic afferent reflex in rats.
Topics: Afferent Pathways; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Bradykinin; Denervation; Electric Stimulation; Heart; Heart Rate; Kidney; Losartan; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Reflex; Sinus of Valsalva; Sympathetic Nervous System; Vagotomy | 2002 |
Diminished arteriolar responses in nitrate tolerance involve ROS and angiotensin II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arterioles; Drug Tolerance; Free Radical Scavengers; Losartan; Male; Metalloporphyrins; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase; Vasodilation | 2002 |
Postnatal hypoxemia increases angiotensin II sensitivity and up-regulates AT1a angiotensin receptors in rat carotid body chemoreceptors.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Calcium; Carotid Body; Dose-Response Relationship, Drug; Hypoxia; Imidazoles; Losartan; Models, Animal; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; Spectrometry, Fluorescence | 2002 |
Angiotensin II stimulation of Na+/K+ATPase activity and cell growth by calcium-independent pathway in MCF-7 breast cancer cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Breast Neoplasms; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Female; Gene Expression; Humans; Losartan; Oligopeptides; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; Sodium-Potassium-Exchanging ATPase; Stimulation, Chemical; Tumor Cells, Cultured | 2002 |
Differences in AT2 -receptor stimulation between AT1 -receptor blockers valsartan and losartan quantified by renal interstitial fluid cGMP.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Cyclic GMP; Extracellular Space; Female; Imidazoles; Injections, Intravenous; Kidney; Losartan; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles; Valine; Valsartan | 2002 |
Potentiation of [Ca2+]i response to angiotensin III by cAMP in cortical thick ascending limb.
Topics: Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Arginine Vasopressin; Biological Transport; Calcium; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; In Vitro Techniques; Intracellular Membranes; Kidney Cortex; Loop of Henle; Losartan; Male; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1 | 2002 |
Effects of long-term enalapril and losartan therapy of heart failure on cardiovascular aldosterone.
Topics: Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiac Output, Low; Cardiomegaly; Cardiovascular System; Chronic Disease; Enalapril; Losartan; Male; Mesenteric Arteries; Myocardial Infarction; Rats; Rats, Wistar | 2002 |
Angiotensin actions on the isolated rat uterus during the estrous cycle: influence of resting membrane potential and uterine morphology.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Dose-Response Relationship, Drug; Estrous Cycle; Female; Imidazoles; In Vitro Techniques; Losartan; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Uterus; Vasoconstrictor Agents | 2002 |
Angiotensin II induces apoptosis in rat glomerular epithelial cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antibodies; Antihypertensive Agents; bcl-2-Associated X Protein; Cells, Cultured; DNA Fragmentation; Epithelial Cells; Fas Ligand Protein; fas Receptor; Imidazoles; Kidney Glomerulus; Losartan; Membrane Glycoproteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Transforming Growth Factor beta; Transforming Growth Factor beta1; Vasoconstrictor Agents | 2002 |
Effect of exogenous and endogenous angiotensin II on intrarenal distribution of glomerular filtration rate in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aprotinin; Glomerular Filtration Rate; Hemostatics; Juxtaglomerular Apparatus; Kidney; Kidney Cortex; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renal Circulation; Vascular Resistance | 2002 |
Effects of losartan on the blood-brain barrier permeability in long-term nitric oxide blockade-induced hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Blood-Brain Barrier; Coloring Agents; Enzyme Inhibitors; Evans Blue; Hypertension; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar | 2002 |
The effect of losartan on calcium uptake by bovine aortic media in vitro.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Cattle; Culture Techniques; Losartan; Muscle, Smooth, Vascular; Nifedipine; Receptor, Angiotensin, Type 1 | 2002 |
Angiotensin II regulation of vascular endothelial growth factor and receptors Flt-1 and KDR/Flk-1 in cyclosporine nephrotoxicity.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Cyclosporine; Disease Models, Animal; Enalapril; Endothelial Growth Factors; Extracellular Matrix Proteins; Gene Expression; Immunosuppressive Agents; Intercellular Signaling Peptides and Proteins; Kidney Diseases; Losartan; Lymphokines; Male; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors | 2002 |
Central AT1 receptors are involved in the enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure.
Topics: Anesthetics, Local; Angiotensin II; Animals; Anti-Arrhythmia Agents; Bradykinin; Capsaicin; Heart Failure; Heart Ventricles; Hemodynamics; Injections, Intravenous; Injections, Intraventricular; Lidocaine; Ligation; Losartan; Male; Myocardial Infarction; Myocardium; Neurons, Afferent; Organ Size; Pericardium; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Reflex; Renin; Sympathetic Nervous System; Ventricular Function | 2002 |
Losartan attenuates renal vasoconstriction in response to acute unilateral ureteral occlusion in pigs.
Topics: Acute Disease; Aldosterone; Angiotensin II; Animals; Glomerular Filtration Rate; Kidney; Losartan; Pelvis; Pressure; Renal Circulation; Swine; Ureteral Obstruction; Vascular Resistance; Vasoconstriction | 2002 |
Angiotensin II and cAMP regulate AT(1)-mRNA expression in rat cardiomyocytes by transcriptional mechanism.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Cells, Cultured; Cyclic AMP; Down-Regulation; Humans; Imidazoles; Losartan; Myocardium; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; RNA, Messenger; Tetrazoles; Transfection | 2002 |
Ischemia promotes renin activation and angiotensin formation in sympathetic nerve terminals isolated from the human heart: contribution to carrier-mediated norepinephrine release.
Topics: Angiotensin II; Antihypertensive Agents; Female; Heart Atria; Heart Conduction System; Humans; Imidazoles; In Vitro Techniques; Losartan; Male; Middle Aged; Myocardial Ischemia; Norepinephrine; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Renin; Sympathetic Nervous System; Synaptosomes; Tetrazoles | 2002 |
Cyclic AMP-dependent protein kinase-independent angiotensin II-induced inhibition of calcium current in hamster submandibular ganglion neurons.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium Channels; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Ganglia; Losartan; Neurons; Signal Processing, Computer-Assisted; Statistics as Topic; Submandibular Gland | 2002 |
Activation of angiotensin II type I receptor promotes protein kinase C translocation and cell proliferation in human cultured breast epithelial cells.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Biological Transport; Breast; Calcium Signaling; Carbazoles; Cell Division; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Estrenes; Female; Humans; Indoles; Isoenzymes; Losartan; Protein Kinase C; Pyrrolidinones; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Staurosporine; Thapsigargin; Type C Phospholipases | 2002 |
Role of endothelin receptors in the hypertensive state of kinin B(2) knockout mice subjected to a high-salt diet.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Female; Hypertension; Kidney; Losartan; Male; Mice; Mice, Knockout; Myocardium; Oligopeptides; Peptides, Cyclic; Piperidines; Protein Precursors; Receptor, Bradykinin B2; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Angiotensin; Receptors, Bradykinin; Receptors, Endothelin; RNA, Messenger; Sodium Chloride, Dietary | 2002 |
Sympatholytic properties of several AT1-receptor antagonists in the isolated rabbit thoracic aorta.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Benzimidazoles; Benzoates; Biphenyl Compounds; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Irbesartan; Losartan; Norepinephrine; Osmolar Concentration; Rabbits; Receptor, Angiotensin, Type 1; Sympathetic Nervous System; Sympatholytics; Synaptic Transmission; Telmisartan; Tetrazoles | 2002 |
[Addition of an angiotensin II receptor blocker to maximal dose of ACE inhibitors in heart failure].
Topics: Adult; Aged; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Data Interpretation, Statistical; Echocardiography; Female; Heart Failure; Hemodynamics; Humans; Losartan; Male; Middle Aged; Oxygen Consumption; Time Factors; Ventricular Dysfunction, Left | 2002 |
No morbidity-mortality. Commentary.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin II; Angiotensin Receptor Antagonists; Atenolol; Diabetes Complications; Diabetes Mellitus; Follow-Up Studies; Humans; Hypertension; Hypertrophy, Left Ventricular; Losartan; Middle Aged; Morbidity; Patient Selection | 2002 |
Interaction between paraventricular nucleus and septal area in the control of physiological responses induced by angiotensin II.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Diuresis; Drinking; Imidazoles; Losartan; Male; Natriuresis; Paraventricular Hypothalamic Nucleus; Pyridines; Rats; Rats, Sprague-Dawley; Septal Nuclei; Sodium, Dietary; Vasoconstrictor Agents | 2002 |
Angiotensin II increases intracellular calcium concentration in pig endometrial stromal cells through type 1 angiotensin receptors, but does not stimulate phospholipase C activity or prostaglandin F2alpha secretion.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium; Dinoprost; Endometrium; Female; Losartan; Oxytocin; Phospholipases; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Stromal Cells; Swine | 2002 |
Angiotensin II receptor blocker-associated angioedema: on the heels of ACE inhibitor angioedema.
Topics: Adult; Angioedema; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Cough; Diabetes Mellitus, Type 1; Enalapril; Female; Humans; Losartan; Pharyngitis | 2002 |
Nonpeptide antagonists of AT1 receptor for angiotensin II delay the onset of acute respiratory distress syndrome.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Bordetella bronchiseptica; Bordetella Infections; Calcium; Kinetics; Losartan; Lung; Male; Neutrophils; Oxygen; Peroxidase; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Respiratory Distress Syndrome | 2002 |
Cross-talk between AT(1) and AT(2) angiotensin receptors in rat anococcygeus smooth muscle.
Topics: Angiotensin II; Animals; Imidazoles; Kinetics; Losartan; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Prazosin; Pyridines; Rats; Rats, Wistar; Receptor Cross-Talk; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 2002 |
Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice.
Topics: Actins; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cells, Cultured; Drug Synergism; Fibroblasts; Fibrosis; Genetic Therapy; Hepatocyte Growth Factor; Humans; Kidney; Kidney Tubules; Losartan; Male; Mice; Mice, Inbred Strains; Muscle, Smooth; Receptor, Angiotensin, Type 1; Transforming Growth Factor beta; Transforming Growth Factor beta1; Ureteral Obstruction | 2002 |
Iron overload augments angiotensin II-induced cardiac fibrosis and promotes neointima formation.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Blotting, Western; Disease Models, Animal; Drug Synergism; Fibrosis; Heart; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hypertension; Immunohistochemistry; Iron Chelating Agents; Iron Overload; Iron-Dextran Complex; Losartan; Male; Myocardium; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Tunica Intima; Vasodilator Agents | 2002 |
Effect of angiotensin II on ion transport across human Fallopian tube epithelial cells in vitro.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Biological Transport; Captopril; Cell Culture Techniques; Electrophysiology; Epithelial Cells; Fallopian Tubes; Female; Humans; Ion Transport; Losartan; Middle Aged; Receptor, Angiotensin, Type 1 | 2002 |
Contribution of angiotensin II internalization to intrarenal angiotensin II levels in rats.
Topics: Angiotensin I; Angiotensin II; Angiotensinogen; Animals; Antihypertensive Agents; Diet, Sodium-Restricted; Kidney Cortex; Kidney Medulla; Losartan; Male; Peptidyl-Dipeptidase A; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Renin; Renin-Angiotensin System; Sodium Chloride, Dietary | 2002 |
Activation of hypothalamic angiotensin receptors produces pressor responses via cholinergic inputs to the rostral ventrolateral medulla in normotensive and hypertensive rats.
Topics: Acetylcholine; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Carbachol; Cholinergic Agonists; Cholinergic Fibers; Cholinesterase Inhibitors; Electric Stimulation; gamma-Aminobutyric Acid; Hypertension; Hypothalamus, Anterior; Iontophoresis; Losartan; Male; Medulla Oblongata; Microinjections; Muscarinic Antagonists; Neural Pathways; Physostigmine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Scopolamine; Vasoconstrictor Agents | 2002 |
Impaired responsiveness of renal mechanosensory nerves in heart failure: role of endogenous angiotensin.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Dinoprostone; Heart Failure; Kidney; Losartan; Male; Models, Animal; Natriuresis; Neurons, Afferent; Pressure; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Sodium; Sodium, Dietary; Substance P | 2003 |
Apoptosis, myocardial fibrosis and angiotensin II in the left ventricle of hypertensive rats treated with fosinopril or losartan.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Apoptosis; Blood Pressure; Fibrosis; Fosinopril; Hypertension; Hypertrophy, Left Ventricular; Losartan; Myocardium; Rats; Rats, Inbred SHR | 2002 |
Antithrombotic effect of captopril and losartan is mediated by angiotensin-(1-7).
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Epoprostenol; Fibrinolytic Agents; Hypertension, Renal; Imidazoles; Infusions, Intravenous; Losartan; Male; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Tetrazoles; Venous Thrombosis | 2002 |
ANG II AT2 receptor modulates AT1 receptor-mediated descending vasa recta endothelial Ca2+ signaling.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium; Calcium Signaling; Cytoplasm; Endothelium, Vascular; Imidazoles; In Vitro Techniques; Kidney Medulla; Losartan; Manganese; Microcirculation; Muscle, Smooth, Vascular; Pericytes; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Vasoconstriction; Vasodilator Agents | 2003 |
Intracellular angiotensin II increases the long isoform of PDGF mRNA in rat hepatoma cells.
Topics: Amides; Amino Acid Sequence; Angiotensin II; Animals; Carboxypeptidase H; Carboxypeptidases; Cold Temperature; Disulfiram; Enzyme Precursors; Fatty Acids, Monounsaturated; Genes, Reporter; Green Fluorescent Proteins; Intracellular Fluid; Liver Neoplasms, Experimental; Losartan; Luminescent Proteins; Mixed Function Oxygenases; Molecular Sequence Data; Multienzyme Complexes; Mutagenesis, Site-Directed; Neoplasm Proteins; Peptide Fragments; Plasmids; Platelet-Derived Growth Factor; Protein Folding; Protein Processing, Post-Translational; Protein Sorting Signals; Rats; RNA, Messenger; RNA, Neoplasm; Transfection; Tumor Cells, Cultured | 2002 |
Conversion of brain angiotensin II to angiotensin III is critical for pressor response in rats.
Topics: Aminopeptidases; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Brain; CD13 Antigens; Dose-Response Relationship, Drug; Glutamyl Aminopeptidase; Injections, Intraventricular; Losartan; Male; Methionine; Rats; Rats, Sprague-Dawley; Stereoisomerism; Sulfonic Acids; Vasoconstrictor Agents | 2003 |
Contrasting effects of angiotensin type 1 and 2 receptors on nitric oxide release under pressure.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Apoptosis; Bradykinin; Cell Count; Cells, Cultured; Endothelium, Vascular; Gene Expression; Glyceraldehyde-3-Phosphate Dehydrogenases; In Vitro Techniques; Losartan; Male; Nitrates; Nitric Oxide; Nitrites; Oxygen; Pressure; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 2002 |
Comparison of the antagonistic effects of different angiotensin II receptor blockers in human coronary arteries.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Base Sequence; Benzimidazoles; Biphenyl Compounds; Coronary Vessels; Culture Techniques; Dose-Response Relationship, Drug; Female; Humans; Imidazoles; Losartan; Male; Middle Aged; Molecular Sequence Data; Probability; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazoles; Valine; Valsartan; Vasoconstriction | 2002 |
Long-term angiotensin II inhibition increases mitochondrial nitric oxide synthase and not antioxidant enzyme activities in rat heart.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Catalase; Enalapril; Glutathione Peroxidase; Hydrogen Peroxide; Losartan; Male; Mitochondria, Heart; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Oxidoreductases; Rats; Rats, Wistar; Superoxide Dismutase; Time Factors | 2002 |
Tumor necrosis factor-alpha-induced AT1 receptor upregulation enhances angiotensin II-mediated cardiac fibroblast responses that favor fibrosis.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Cardiomyopathies; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Matrix; Fibroblasts; Fibrosis; Imidazoles; Losartan; Matrix Metalloproteinase 2; Proline; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tissue Inhibitor of Metalloproteinase-1; Tumor Necrosis Factor-alpha; Up-Regulation | 2002 |
Estrogens inhibit angiotensin II-induced leukocyte-endothelial cell interactions in vivo via rapid endothelial nitric oxide synthase and cyclooxygenase activation.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antibodies, Monoclonal; Cell Adhesion; Cell Communication; Cell Movement; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Estradiol; Estrogen Antagonists; Estrogens; Humans; In Vitro Techniques; Leukocytes; Losartan; Lymphatic System; Male; Nitric Oxide Synthase; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Selective Estrogen Receptor Modulators; Splanchnic Circulation | 2002 |
Angiotensin receptors contribute to blood pressure homeostasis in salt-depleted SHR.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Homeostasis; Imidazoles; Immune Sera; Losartan; Male; Pyridines; Rats; Rats, Inbred SHR; Receptors, Angiotensin; Sodium; Time Factors | 2003 |
[Regulation of alpha(1) type I collagen promoter by cytokines and losartan].
Topics: Angiotensin II; Animals; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Collagen Type I; Collagen Type I, alpha 1 Chain; Cytokines; Gene Expression Regulation; Losartan; Promoter Regions, Genetic; Rats; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2002 |
The functional role of the JAK-STAT pathway in post-infarction remodeling.
Topics: Angiotensin II; Animals; Anti-Arrhythmia Agents; Apoptosis; DNA-Binding Proteins; Janus Kinase 1; Janus Kinase 2; Losartan; Milk Proteins; Models, Animal; Myocardial Infarction; Myocardium; Potassium Channels; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; STAT5 Transcription Factor; Time Factors; Trans-Activators; Tyrphostins; Ventricular Remodeling | 2003 |
Control of dendritic cell differentiation by angiotensin II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antibodies; Benzimidazoles; Biphenyl Compounds; Cell Differentiation; Cells, Cultured; Dendritic Cells; Endocytosis; Hematopoietic Stem Cells; Humans; Irbesartan; Losartan; Lymphocyte Activation; Mice; Models, Biological; Monocytes; Phenotype; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles | 2003 |
Effect of blockade of endogenous angiotensin II on baroreflex function in conscious diabetic rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Consciousness; Diabetes Mellitus, Experimental; Enalapril; Heart Rate; Kidney; Losartan; Male; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System | 2003 |
Cysteinyl leukotriene-dependent [Ca2+]i responses to angiotensin II in cardiomyocytes.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Arginine Vasopressin; Benzoquinones; Calcium; Cysteine; Endothelin-1; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Heart; Imidazoles; Inositol 1,4,5-Trisphosphate; Leukotriene C4; Leukotriene D4; Leukotrienes; Lipoxygenase Inhibitors; Losartan; Myocardium; Propionates; Pyridines; Quinolines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Spectrometry, Fluorescence | 2003 |
[Effects of lorsartan, fosinopril on myocardial fibrosis, angiotensin II and cardiac remolding in hypertensive rats].
Topics: Angiotensin II; Animals; Antihypertensive Agents; Fibrosis; Fosinopril; Hypertension; Losartan; Male; Myocardium; Random Allocation; Rats; Rats, Inbred SHR; Ventricular Remodeling | 2001 |
[Effects of angiotensin II on the 3H-TdR incorporation and synthesis of collagen in cultured bovine trabecular meshwork cells].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cattle; Cell Division; Cells, Cultured; Collagen; Losartan; Thymidine; Trabecular Meshwork | 2001 |
Binding of KRH-594, an antagonist of the angiotensin II type 1 receptor, to cloned human and rat angiotensin II receptors.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Chlorocebus aethiops; COS Cells; Dose-Response Relationship, Drug; Humans; Imidazoles; In Vitro Techniques; Liver; Losartan; Membranes; Oligopeptides; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles; Thiadiazoles; Time Factors; Transfection | 2002 |
Angiotensin II induces a rapid and transient increase of reactive oxygen species.
Topics: Acrylates; Angiotensin II; Animals; Benzoates; Catalase; Cells, Cultured; Ditiocarb; Enzyme Inhibitors; Fluoresceins; Fluorescence; Hydrogen Peroxide; Indomethacin; Losartan; Muscle, Smooth, Vascular; NADH, NADPH Oxidoreductases; Onium Compounds; Pertussis Toxin; Phospholipases A; Phospholipases A2; Rats; Rats, Wistar; Reactive Oxygen Species | 2002 |
[Treatment of hypertension: angiotensin-II antagonists potentially better than beta-blockers in the occurrence of cardiovascular and cerebrovascular damage; the LIFE study in perspective].
Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Atenolol; Cardiovascular Diseases; Cerebrovascular Disorders; Humans; Hypertension; Losartan; Randomized Controlled Trials as Topic; Renin-Angiotensin System; Treatment Outcome | 2003 |
Cardiovascular and renal effects of cyclooxygenase inhibition in transgenic rats harboring mouse renin-2 gene (TGR[mREN2]27).
Topics: Albuminuria; Angiotensin II; Animals; Animals, Genetically Modified; Antihypertensive Agents; Blood Pressure; Body Weight; Cardiomegaly; Cardiovascular System; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Eating; Furans; Gene Expression Regulation, Enzymologic; Isoenzymes; Kidney; Losartan; Male; Membrane Proteins; Mice; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Renin; RNA, Messenger; Sulindac; Urination | 2003 |
Synergistic effects of mycophenolate mofetil and losartan in a model of chronic cyclosporine nephropathy.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Arterioles; Blood Pressure; Body Weight; Chronic Disease; Cyclosporine; Drug Synergism; Fibrosis; Gene Expression; Immunosuppressive Agents; Kidney; Kidney Diseases; Losartan; Macrophages; Male; Mycophenolic Acid; Osteopontin; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sialoglycoproteins; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2003 |
Angiotensin II activates NADPH oxidase in isolated rat hearts subjected to ischaemia-reperfusion.
Topics: Angiotensin II; Animals; Arrhythmias, Cardiac; Coronary Circulation; Enzyme Activation; Heart; In Vitro Techniques; L-Lactate Dehydrogenase; Losartan; Male; Membrane Glycoproteins; Membrane Transport Proteins; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; NADPH Dehydrogenase; NADPH Oxidase 2; NADPH Oxidases; Perfusion; Phosphoproteins; Rats; Rats, Wistar; RNA, Messenger; Vasoconstrictor Agents; Ventricular Function, Left | 2003 |
Non-peptide angiotensin II receptor antagonists: chemical feature based pharmacophore identification.
Topics: Acrylates; Algorithms; Angiotensin II; Biphenyl Compounds; Databases, Factual; Imidazoles; Lactones; Losartan; Models, Molecular; Molecular Conformation; Pyridines; Quantitative Structure-Activity Relationship; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Sulfones; Tetrazoles; Thiophenes | 2003 |
Divergent roles of angiotensin II AT1 and AT2 receptors in modulating coronary microvascular function.
Topics: Adenosine; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arterioles; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; Imidazoles; In Vitro Techniques; Losartan; Microcirculation; NADPH Oxidases; Nitric Oxide; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Superoxides; Swine; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Vasomotor System | 2003 |
Effects of AT1 and AT2 receptor blockade on angiotensin II induced apoptosis of human renal proximal tubular epithelial cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Apoptosis; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Epithelial Cells; Flow Cytometry; Humans; Imidazoles; In Situ Nick-End Labeling; In Vitro Techniques; Kidney Failure, Chronic; Kidney Tubules; Losartan; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2 | 2002 |
Metallothionein prevents diabetes-induced deficits in cardiomyocytes by inhibiting reactive oxygen species production.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium; Diabetes Complications; Diabetes Mellitus; Enzyme Inhibitors; Gene Expression; Glucose; Losartan; Metallothionein; Mice; Mice, Transgenic; Myocardial Contraction; Myocardium; NADPH Oxidases; Onium Compounds; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Spectrometry, Fluorescence | 2003 |
Angiotensin II-induced release of oxytocin: interaction with norepinephrine and role in lactation.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Suckling; Female; Imidazoles; Injections, Intraventricular; Lactation; Losartan; Norepinephrine; Oxytocin; Phentolamine; Pyridines; Rats; Third Ventricle | 2003 |
The effects of sarmesin, an Angiotensin II analogue on seizure susceptibility, memory retention and nociception.
Topics: Angiotensin II; Animals; Avoidance Learning; Disease Models, Animal; Drug Combinations; Imidazoles; Injections, Intraventricular; Kindling, Neurologic; Losartan; Male; Memory; Mice; Pain Measurement; Pentylenetetrazole; Pyridines; Seizures; Tail | 2003 |
Role of the angiotensin II system in regulation of ovulation and blood flow in the rat ovary.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Dinoprostone; Drug Synergism; Female; Imidazoles; Laser-Doppler Flowmetry; Losartan; Ovary; Ovulation; Plasminogen Activators; Pyridines; Rats; Rats, Sprague-Dawley; Regional Blood Flow | 2003 |
ANG II is involved in the LPS-induced production of proinflammatory cytokines in dehydrated rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Dehydration; Gene Expression Regulation; Interleukin-1; Interleukin-6; Lipopolysaccharides; Lisinopril; Liver; Losartan; Male; Rats; Rats, Wistar; RNA, Messenger; Time Factors | 2003 |
Chronic angiotensin II infusion attenuates the renal sympathoinhibitory response to acute volume expansion.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Atropine; Blood Pressure; Chlorisondamine; Ganglionic Blockers; Heart Rate; Hematocrit; Kidney; Losartan; Male; Parasympatholytics; Plasma Volume; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System | 2003 |
Role of angiotensin II under prolonged increased intraabdominal pressure (IAP) in pigs.
Topics: Abdomen; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Female; Hormones; Losartan; Male; Pressure; Swine; Time Factors | 2003 |
The role of endogenous angiotensin II in ischaemia, reperfusion and preconditioning of the isolated rat heart.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Female; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Losartan; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers | 2003 |
Are angiotensin II receptor antagonists indicated in chronic heart failure?
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Clinical Trials as Topic; Heart Failure; Humans; Losartan; Tetrazoles; Treatment Outcome; Valine; Valsartan | 2002 |
Localization of AT(2) receptors in the nucleus of the solitary tract of spontaneously hypertensive and Wistar Kyoto rats using [125I] CGP42112: upregulation of a non-angiotensin II binding site following unilateral nodose ganglionectomy.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Autoradiography; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Functional Laterality; Ganglionectomy; Imidazoles; Immunohistochemistry; Iodine Radioisotopes; Losartan; Male; Nodose Ganglion; Oligopeptides; Pyridines; Radioligand Assay; Radiopharmaceuticals; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Solitary Nucleus | 2003 |
Effects of angiotensin II and losartan on the growth and proliferation of hepatic stellate cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Division; Cells, Cultured; Drug Combinations; Hepatocytes; Liver Cirrhosis; Losartan; Male; Rats; Rats, Sprague-Dawley | 2003 |
Functional antagonism of different angiotensin II type I receptor blockers in human arteries.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Dose-Response Relationship, Drug; Humans; Imidazoles; In Vitro Techniques; Losartan; Mammary Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Receptor, Angiotensin, Type 1; Tetrazoles; Valine; Valsartan; Vasoconstrictor Agents | 2002 |
AT1 receptors in the RVLM mediate pressor responses to emotional stress in rabbits.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Baroreflex; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Consciousness; Female; Glutamates; Heart Rate; Hypertension; Kidney; Losartan; Male; Medulla Oblongata; Rabbits; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Stress, Psychological; Sympathetic Nervous System; Tetrazoles | 2003 |
Screening and identification of the up-regulated genes in human mesangial cells exposed to angiotensin II.
Topics: Amino Acid Sequence; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Base Sequence; Blotting, Northern; Cell Nucleus; Cells, Cultured; Cloning, Molecular; DNA, Complementary; Extracellular Matrix; Gene Expression; Glomerular Mesangium; Humans; Losartan; Molecular Sequence Data; Nuclear Proteins; Nucleic Acid Hybridization; Proteins; Up-Regulation; Vasoconstrictor Agents | 2003 |
Effect of angiotensin AT2 receptor stimulation on vascular cyclic GMP production in normotensive Wistar Kyoto rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Imidazoles; Losartan; Male; Minoxidil; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyridines; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 2003 |
Cardiac myofibroblasts: a novel source of vascular endothelial growth factor (VEGF) and its receptors Flt-1 and KDR.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Fibroblasts; Imidazoles; Losartan; Male; Myocardial Infarction; Myocardium; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2003 |
Angiotensin II receptor types 1A, 1B, and 2 in murine neuroblastoma Neuro-2a cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Base Sequence; Blotting, Western; DNA, Complementary; Gene Expression; Inositol 1,4,5-Trisphosphate; Losartan; Mice; Microscopy, Fluorescence; Neuroblastoma; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured | 2003 |
Conformational and biological studies for a pair of novel synthetic AT1 antagonists: stereoelectronic requirements for antihypertensive efficacy.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Benzyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Losartan; Magnetic Resonance Spectroscopy; Male; Models, Molecular; Molecular Conformation; Rabbits; Receptor, Angiotensin, Type 1 | 2003 |
Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bleeding Time; Captopril; Disease Models, Animal; Endothelium, Vascular; Female; Hemodynamics; Losartan; Myocardial Infarction; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Refractory Period, Electrophysiological; Vasodilation; Ventricular Fibrillation | 2003 |
Role of the renin-angiotensin system in the compensation of quinpirole-induced blood pressure decrease.
Topics: Anesthesia; Angiotensin II; Animals; Blood Pressure; Denervation; Dose-Response Relationship, Drug; Heart Rate; Hypotension; Kidney; Kidney Function Tests; Losartan; Male; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Renin-Angiotensin System | 2003 |
Angiotensin-II-induced enhanced expression of Gi proteins is attenuated by losartan in A10 vascular smooth muscle cells: role of AT1 receptors.
Topics: Adenylyl Cyclases; Angiotensin II; Animals; Blotting, Northern; Cells, Cultured; GTP-Binding Protein alpha Subunits, Gi-Go; Immunoblotting; Losartan; Muscle, Smooth, Vascular; Mutation; Rats; Receptor, Angiotensin, Type 1; RNA | 2003 |
Enalaprilat, losartan and LU 135252 in coronary blood flow regulation.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Bradykinin; Coronary Circulation; Enalaprilat; Female; Losartan; Male; Phenylpropionates; Pyrimidines; Swine | 2003 |
NAD(P)H oxidase activation by angiotensin II is dependent on p42/44 ERK-MAPK pathway activation in rat's vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Aorta; Blood Pressure; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Hypertension; Losartan; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Cardiovascular; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; Rats; Rats, Sprague-Dawley; Superoxides; Thioctic Acid; Vasoconstrictor Agents | 2003 |
Effect of losartan on insulin plasma concentrations and LPL activity in adipose tissue of hypertensive rats.
Topics: Adipose Tissue; Adrenal Glands; Angiotensin II; Animals; Antihypertensive Agents; Constriction; Hypertension, Renovascular; Insulin; Lipoprotein Lipase; Losartan; Male; Organ Size; Rats; Rats, Wistar; Renal Artery | 2003 |
Effect of losartan on oxidative stress-induced hypertension in Sprague-Dawley rats.
Topics: Aldosterone; Angiotensin II; Animals; Antihypertensive Agents; Aorta; Biomarkers; Blood Pressure; Buthionine Sulfoximine; Cyclic AMP; Cyclic GMP; Dinoprost; Disease Models, Animal; Enzyme Inhibitors; Epoprostenol; F2-Isoprostanes; Glutathione; Heart Rate; Hypertension; Kidney; Losartan; Male; Models, Cardiovascular; Nitric Oxide; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxides; Thromboxane A2; Treatment Outcome | 2003 |
Angiotensin II and the fibroproliferative response to acute lung injury.
Topics: Acute Disease; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antibiotics, Antineoplastic; Antihypertensive Agents; Bleomycin; Cell Division; Cells, Cultured; Collagen; Fibroblasts; Humans; Losartan; Lung; Peptidyl-Dipeptidase A; Procollagen; Pulmonary Fibrosis; Ramipril; Renin-Angiotensin System; Transforming Growth Factor beta | 2004 |
Influence of angiotensin II receptor subtypes of the paraventricular nucleus on the physiological responses induced by angiotensin II injection into the medial septal area.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Diuresis; Drinking; Homeostasis; Imidazoles; Losartan; Male; Paraventricular Hypothalamic Nucleus; Pyridines; Rats; Rats, Sprague-Dawley; Saralasin; Septum of Brain; Sodium; Vasoconstrictor Agents | 2003 |
AngRem104, an angiotensin II-induced novel upregulated gene in human mesangial cells, is potentially involved in the regulation of fibronectin expression.
Topics: Amino Acid Sequence; Angiotensin II; Angiotensin Receptor Antagonists; Base Sequence; DNA, Complementary; Fibronectins; Glomerular Mesangium; Humans; Kidney Glomerulus; Kidney Tubules; Losartan; Molecular Sequence Data; Nuclear Proteins; Receptor, Angiotensin, Type 1; RNA, Messenger; Tissue Distribution; Up-Regulation | 2003 |
Oxidized LDL and its compound lysophosphatidylcholine potentiate AngII-induced vasoconstriction by stimulation of RhoA.
Topics: ADP Ribose Transferases; Amides; Angiotensin II; Animals; Aorta; Biological Transport; Cattle; Cells, Cultured; Clostridium; Drug Synergism; Felodipine; Female; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Lipoproteins, LDL; Losartan; Lysophosphatidylcholines; Male; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; rhoA GTP-Binding Protein; Vasoconstriction; Vasoconstrictor Agents | 2003 |
Angiotensin II modulates nitric oxide-induced cardiac fibroblast apoptosis by activation of AKT/PKB.
Topics: Angiotensin II; Animals; Apoptosis; Fibroblasts; Interleukin-1; Losartan; Male; Myocardium; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroso Compounds; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Vasoconstrictor Agents | 2003 |
[Hemodynamics and cell membrane effects of angiotensin II receptor antagonists in treatment of hypertension].
Topics: Adenosine Triphosphatases; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Platelets; Calcium; Erythrocytes; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Losartan; Membrane Potentials; Membrane Proteins; Middle Aged; Peptidyl-Dipeptidase A | 2003 |
Ureteral function is modulated by a local renin-angiotensin system.
Topics: Adult; Angiotensin II; Animals; Electric Stimulation; Humans; Immunohistochemistry; In Vitro Techniques; Losartan; Muscle Contraction; Muscle, Smooth; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; Swine; Ureter | 2003 |
Biphasic effects of angiotensin (1-7) and its interactions with angiotensin II in rat aorta.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Aorta, Thoracic; Drug Interactions; Imidazoles; In Vitro Techniques; Losartan; Male; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2003 |
Increased pressor sensitivity to chronic nitric oxide deficiency in hyperthyroid rats.
Topics: Angiotensin II; Animals; Blood Pressure; Creatinine; Enzyme Inhibitors; Heart Rate; Hyperthyroidism; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Potassium; Proteinuria; Rats; Rats, Wistar; Sodium; Thyroxine | 2003 |
Angioedema and AT1 receptor blockers: proceed with caution.
Topics: Angioedema; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Humans; Losartan | 2003 |
AT1 and AT2 receptors in human glomerular endothelial cells at different passages.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Antihypertensive Agents; Blotting, Western; Cell Culture Techniques; Cell Division; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Imidazoles; Kidney Glomerulus; Kinetics; Losartan; Platelet-Derived Growth Factor; Protein Binding; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Reverse Transcriptase Polymerase Chain Reaction; Thymidine; Time Factors | 2003 |
Functional comparison of the antagonistic properties of some Angiotensin II type 1 receptor blockers on the contraction elicited by Angiotensin II and thromboxane A2 on human saphenous veins.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Biphenyl Compounds; Drug Antagonism; Humans; Imidazoles; In Vitro Techniques; Irbesartan; Losartan; Muscle Contraction; Muscle, Smooth, Vascular; Receptors, Thromboxane A2, Prostaglandin H2; Saphenous Vein; Tetrazoles; Valine; Valsartan | 2003 |
Losartan corrects abnormal frequency response of renal vasculature in congestive heart failure.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Heart Failure; Kidney; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renal Circulation; Sympathetic Nervous System; Vasoconstrictor Agents | 2003 |
Angiotensin II stimulates spinally projecting paraventricular neurons through presynaptic disinhibition.
Topics: Action Potentials; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; gamma-Aminobutyric Acid; Imidazoles; Immunohistochemistry; In Vitro Techniques; Losartan; Male; Neural Inhibition; Neurons; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Presynaptic Terminals; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Spinal Cord; Synaptophysin | 2003 |
Angiotensin II and III microinjections into the zona incerta influence drinking behavior.
Topics: Angiotensin II; Angiotensin III; Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Drinking; Drinking Behavior; Drug Interactions; Imidazoles; Losartan; Male; Microinjections; Oligopeptides; Pyridines; Rats; Subthalamus; Time Factors | 2003 |
Effect of losartan on renal microvasculature during chronic inhibition of nitric oxide visualized by micro-CT.
Topics: Angiography; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Vessels; Enzyme Inhibitors; Kidney; Losartan; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Circulation; Tomography, X-Ray Computed | 2003 |
Angiotensin II mediates LDL-induced superoxide generation in mesangial cells.
Topics: Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Cell Division; Cells, Cultured; Enzyme Inhibitors; Glomerular Mesangium; Humans; Hypertrophy; Lipoproteins, LDL; Losartan; NADPH Oxidases; Onium Compounds; Receptor, Angiotensin, Type 1; RNA, Messenger; Superoxides | 2003 |
Further studies on the effect of intracellular angiotensins on heart cell communication: on the role of endogenous angiotensin II.
Topics: Angiotensin II; Animals; Cell Communication; Cricetinae; Dose-Response Relationship, Drug; Enalapril; Enalaprilat; Losartan; Male; Mesocricetus; Myocardium; Patch-Clamp Techniques; Peptides; Peptidyl-Dipeptidase A; Receptors, Angiotensin; Renin-Angiotensin System; Temperature; Time Factors | 2003 |
Activation and functional significance of the renin-angiotensin system in mice with cardiac restricted overexpression of tumor necrosis factor.
Topics: Age Factors; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Animals; Body Weight; Cardiomegaly; Collagen; Hemodynamics; Losartan; Mice; Mice, Transgenic; Myocardium; Organ Size; Organ Specificity; Peptidyl-Dipeptidase A; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin; Renin-Angiotensin System; RNA, Messenger; Tumor Necrosis Factor-alpha; Ventricular Remodeling | 2003 |
Effect of high glucose, angiotensin II and receptor antagonist Losartan on the expression of connective tissue growth factor in cultured mesangial cells.
Topics: Angiotensin II; Animals; Cells, Cultured; Connective Tissue Growth Factor; Gene Expression; Glomerular Mesangium; Glucose; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Losartan; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2003 |
Angiotensin II type 2 receptor inhibits vascular endothelial growth factor-induced migration and in vitro tube formation of human endothelial cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Apoptosis; Blotting, Western; Cell Line; Cell Movement; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Losartan; Lymphokines; Neovascularization, Physiologic; Oligopeptides; Pertussis Toxin; Phosphorylation; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors | 2003 |
Myogenic constriction is increased in mesenteric resistance arteries from rats with chronic heart failure: instantaneous counteraction by acute AT1 receptor blockade.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Captopril; Chronic Disease; Coronary Vessels; Disease Models, Animal; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Fatty Acids, Unsaturated; Heart; Heart Failure; Hydrazines; Imidazoles; Indomethacin; Lisinopril; Losartan; Male; Mesenteric Arteries; Nitric Oxide; omega-N-Methylarginine; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Superoxide Dismutase; Sympathetic Nervous System; Tetrazoles; Tetrodotoxin; Vascular Resistance | 2003 |
Role of prostaglandin, endothelin and sympathetic nervous system on the L-NAME-induced pressor responses in spontaneously hypertensive rats.
Topics: Acetamides; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Chlorisondamine; Cyclooxygenase Inhibitors; Endothelin Receptor Antagonists; Endothelins; Enzyme Inhibitors; Ganglionic Blockers; Heart Rate; Indomethacin; Injections, Intraventricular; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oligopeptides; Prostaglandins; Rats; Rats, Inbred SHR; Sympathetic Nervous System | 2003 |
Expression of angiotensin II type 1 receptor in rat hepatic stellate cells and its effects on cell growth and collagen production.
Topics: Angiotensin II; Animals; Base Sequence; Cell Division; Cell Line, Transformed; Collagen; Dose-Response Relationship, Drug; Hepatocytes; Losartan; Molecular Sequence Data; Osmolar Concentration; Rats; Receptor, Angiotensin, Type 1 | 2003 |
[Efficacy of losartan treatment of right ventricular cardiac insufficiency in patients with chronic obstructive bronchitis].
Topics: Adult; Angiotensin II; Bronchitis, Chronic; Drug Therapy, Combination; Hemodynamics; Humans; Losartan; Lung Diseases, Obstructive; Middle Aged; Treatment Outcome; Ventricular Dysfunction, Right | 2003 |
Connective tissue growth factor is a mediator of angiotensin II-induced fibrosis.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Cells, Cultured; Connective Tissue Growth Factor; Drug Administration Routes; Drug Administration Schedule; Extracellular Matrix Proteins; Female; Fibrosis; Gene Expression; Imidazoles; Immediate-Early Proteins; Immunohistochemistry; Infusion Pumps, Implantable; Intercellular Signaling Peptides and Proteins; Losartan; Muscle, Smooth, Vascular; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger | 2003 |
Angiotensin II-dependent increased expression of Na+-glucose cotransporter in hypertension.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Cell Membrane; Gene Expression; Glucose; Hypertension, Renal; Immunoblotting; Kidney Cortex; Losartan; Male; Monosaccharide Transport Proteins; Ramipril; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; RNA, Messenger; Sodium; Sodium-Glucose Transporter 2 | 2004 |
Facilitation of renal autoregulation by angiotensin II is mediated through modulation of nitric oxide.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cyclic N-Oxides; Endothelium-Dependent Relaxing Factors; Erythrocytes; Glomerular Filtration Rate; Homeostasis; Indomethacin; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Perfusion; Phenylephrine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Spin Labels; Vasoconstriction | 2003 |
Angiotensin-converting enzyme inhibitors: optimal management of cardiovascular risk.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Captopril; Cardiovascular Diseases; Diabetic Nephropathies; Evidence-Based Medicine; Humans; Hypertension; Losartan; Risk Management; Treatment Outcome | 2003 |
Protective effects of the angiotensin II type 1 (AT1) receptor blockade in low-renin deoxycorticosterone acetate (DOCA)-treated spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Cardiomegaly; Desoxycorticosterone; Endothelins; Hypertension; Isoprostanes; Kidney; Losartan; Male; Malondialdehyde; Proteinuria; Rats; Rats, Inbred SHR; Renin | 2004 |
[Inhibitory effect of angiotensin II receptor antagonist on the contraction and growth of hepatic stellate cells].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium Channels; Cell Division; Cells, Cultured; Hepatocytes; Losartan; Rats; Rats, Sprague-Dawley | 2003 |
Angiotensin II dependent testicular fibrosis and effects on spermatogenesis after vasectomy in the rat.
Topics: Acetylcysteine; Aldehydes; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Enalapril; Fibrosis; Heat-Shock Proteins; HSP47 Heat-Shock Proteins; Leydig Cells; Losartan; Male; Rats; Rats, Wistar; Spermatogenesis; Testis; Transforming Growth Factor beta; Transforming Growth Factor beta1; Vasectomy | 2003 |
Insulin and losartan reduce proteinuria and renal hypertrophy in the pregnant diabetic rat.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Female; Hypertrophy; Hypoglycemic Agents; Insulin; Kidney; Losartan; Peptidyl-Dipeptidase A; Pregnancy; Pregnancy in Diabetics; Proteinuria; Rats | 2003 |
The receptors and role of angiotensin II in knee joint blood flow regulation and role of nitric oxide in modulation of their function.
Topics: Angiotensin II; Animals; Knee Joint; Losartan; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rabbits; Receptor, Angiotensin, Type 1; Vascular Resistance; Vasoconstriction | 2003 |
AT1b receptor predominantly mediates contractions in major mouse blood vessels.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Abdominal; Aorta, Thoracic; Female; Femoral Artery; In Vitro Techniques; Isometric Contraction; Kidney; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Angiotensin, Type 1; RNA, Messenger; Sex Factors; Vasoconstriction | 2003 |
Evidence for a functional role of angiotensin II type 2 receptor in the cardiac hypertrophic process in vivo in the rat heart.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Atrial Natriuretic Factor; Blood Pressure; Cardiomyopathy, Hypertrophic; Fibroblast Growth Factor 1; Gene Expression Regulation; Genes, fos; Heart Rate; Hypertension; Imidazoles; Infusion Pumps, Implantable; Losartan; Male; Natriuretic Peptide, Brain; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; RNA, Messenger; Vascular Endothelial Growth Factor A | 2003 |
The effects of peptide and nonpeptide antagonists of angiotensin II receptors on the noradrenaline uptake of different brain structures in rats with angiotensin II-induced increase of water intake.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Brain; Drinking Behavior; Imidazoles; Losartan; Male; Norepinephrine; Rats; Rats, Wistar; Saralasin; Tetrazoles | 2003 |
Angiotensin II involvement in adaptive enteric oxalate excretion in rats with chronic renal failure induced by hyperoxaluria.
Topics: Adaptation, Physiological; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biological Transport; Chlorides; Colon; Creatinine; Hyperoxaluria; Intestinal Absorption; Kidney; Kidney Failure, Chronic; Losartan; Male; Osmolar Concentration; Oxalates; Rats; Rats, Sprague-Dawley | 2003 |
[Effect of angiotensin II on tissue factor expression in human peripheral blood monocytes and its mechanisms].
Topics: Angiotensin II; Gene Expression Regulation; Genistein; Humans; Losartan; Monocytes; NF-kappa B; Protein Kinase C; Receptor, Angiotensin, Type 1; RNA, Messenger; Staurosporine; Thromboplastin | 2003 |
Ultrastructural changes in the remnant kidney (after 5/6 nephrectomy) glomerulus after losartan and atenolol treatment.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atenolol; Basement Membrane; Disease Models, Animal; Glomerulosclerosis, Focal Segmental; Hypertrophy; Kidney Failure, Chronic; Kidney Glomerulus; Losartan; Male; Microscopy, Electron; Nephrectomy; Proteinuria; Rats; Rats, Wistar; Systole; Time Factors | 2003 |
Relative roles of nitric oxide, prostanoids and angiotensin II in the regulation of canine glomerular hemodynamics. A micropuncture study.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cyclooxygenase Inhibitors; Dogs; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Hemodynamics; Imidazoles; Indomethacin; Kidney Glomerulus; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Prostaglandins; Renal Circulation; Tetrazoles; Time Factors | 2004 |
[Dosage equivalents of AT1-receptor antagonists available in Germany].
Topics: Acrylates; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Clinical Trials as Topic; Germany; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Olmesartan Medoxomil; Placebos; Telmisartan; Tetrazoles; Therapeutic Equivalency; Thiophenes; Time Factors; Valine; Valsartan | 2003 |
Renal vascular responsiveness to angiotensin II at an early stage of diabetes: interaction between intrarenal noradrenergic and renin-angiotensin systems.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Enalapril; Losartan; Norepinephrine; Rats; Rats, Wistar; Renin-Angiotensin System; Time Factors; Vasoconstriction | 2003 |
The role of Ang (1-7) in mediating the chronic hypotensive effects of losartan in normal rats.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Chronic Disease; Drug Interactions; Heart Rate; Hypotension; Losartan; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley | 2003 |
Angiotensin II signaling pathways mediate expression of cardiac T-type calcium channels.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Bosentan; Butadienes; Calcium Channels, T-Type; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Constriction, Pathologic; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Flavonoids; Gene Expression; Losartan; Male; Membrane Potentials; Mitogen-Activated Protein Kinase Kinases; Myocytes, Cardiac; Nickel; Nitriles; Oligopeptides; Peptides, Cyclic; Piperidines; Rats; Rats, Wistar; Receptors, Angiotensin; Receptors, Endothelin; RNA, Messenger; Signal Transduction; Sulfonamides | 2003 |
Angiotensin II regulation of the Na+ pump involves the phosphatidylinositol-3 kinase and p42/44 mitogen-activated protein kinase signaling pathways in vascular smooth muscle cells.
Topics: Amiloride; Angiotensin II; Animals; Antihypertensive Agents; Aorta, Thoracic; Biological Transport; Cells, Cultured; Diuretics; Losartan; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Sodium-Potassium-Exchanging ATPase; Transcription, Genetic; Vasoconstrictor Agents | 2004 |
Efficacy of losartan in the treatment of erythrocytosis in a young adult with CRF.
Topics: Adult; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Drug Therapy, Combination; Humans; Kidney Failure, Chronic; Lisinopril; Losartan; Male; Polycythemia; Treatment Outcome | 2004 |
Involvement of reactive oxygen species in angiotensin II-induced endothelin-1 gene expression in rat cardiac fibroblasts.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Azepines; Cell Culture Techniques; Cell Division; Endothelin Receptor Antagonists; Endothelin-1; Fibroblasts; Gene Expression; Heart; Losartan; Mitogen-Activated Protein Kinases; Oligopeptides; Oxidation-Reduction; Rats; Reactive Oxygen Species; Receptors, Angiotensin; Receptors, Endothelin; Signal Transduction; Up-Regulation | 2003 |
Chronic administration of losartan reverses cardiovascular changes in hypertensive fructose-fed rats.
Topics: Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Antihypertensive Agents; Endothelium; Fructose; Hypertension; Losartan; Male; Microvascular Angina; Nitric Oxide; Nitric Oxide Synthase; Rats; Receptor, Angiotensin, Type 2 | 2003 |
Coronary microvascular endothelial stunning after acute pressure overload in the conscious dog is caused by oxidant processes: the role of angiotensin II type 1 receptor and NAD(P)H oxidase.
Topics: Acetophenones; Angiotensin II; Animals; Ascorbic Acid; Bradycardia; Bradykinin; Coronary Circulation; Cyclic N-Oxides; Dogs; Hypotension; Ligation; Losartan; Myocardial Stunning; Nitric Oxide; Oxidative Stress; Pressure; Reflex; Spin Labels; Superoxides; Veratrine | 2003 |
Angiotensin II AT(1)-receptor induces biglycan in neonatal cardiac fibroblasts via autocrine release of TGFbeta in vitro.
Topics: Angiotensin II; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Autocrine Communication; Biglycan; Extracellular Matrix Proteins; Fibroblasts; Gene Expression; Losartan; Myocardial Infarction; Myocardium; Proteoglycans; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta | 2003 |
A low dose of angiotensin II increases inotropism through activation of reverse Na(+)/Ca(2+) exchange by endothelin release.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cats; Electrophysiology; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Glycopeptides; Guanidines; In Vitro Techniques; Losartan; Muscle Contraction; Papillary Muscles; Patch-Clamp Techniques; Peptides, Cyclic; Sodium-Calcium Exchanger; Sulfones; Thiourea | 2003 |
Relative roles of endothelin-1 and angiotensin II in experimental post-ischaemic acute renal failure.
Topics: Acute Kidney Injury; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Infusions, Intravenous; Kidney; Losartan; Male; Models, Animal; Rats; Rats, Wistar; Reperfusion Injury; Sulfonamides | 2004 |
Combined renin-angiotensin system blockade and dietary sodium restriction impairs cardiomyocyte contractility.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Body Weight; Dose-Response Relationship, Drug; Heart; Losartan; Male; Myocardial Contraction; Myocytes, Cardiac; Organ Size; Perindopril; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Sodium, Dietary | 2003 |
Evidence for a causal role of the renin-angiotensin system in vascular dysfunction associated with insulin resistance.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Pressure; Calcimycin; Culture Techniques; Endothelium, Vascular; Insulin Resistance; Losartan; Male; NADPH Oxidases; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phenylephrine; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; RNA, Messenger; Superoxides; Vasoconstriction; Vasoconstrictor Agents | 2004 |
Ganglionic action of angiotensin contributes to sympathetic activity in renin-angiotensinogen transgenic mice.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Blood Pressure; Chlorisondamine; Ganglia, Sympathetic; Ganglionic Blockers; Humans; Hypertension; Kidney; Losartan; Mice; Mice, Transgenic; Renin; Renin-Angiotensin System; Sympathetic Nervous System | 2004 |
Effect of a perinatal high-salt diet on blood pressure control mechanisms in young Sprague-Dawley rats.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Antihypertensive Agents; Baroreflex; Blood Pressure; Female; Ganglionic Blockers; Heart Rate; In Situ Hybridization; Injections, Intraventricular; Losartan; Pregnancy; Rats; Rats, Sprague-Dawley; Renin; Sodium Chloride, Dietary; Subfornical Organ; Sympathetic Nervous System | 2004 |
Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensinogen; Animals; Blotting, Western; Dose-Response Relationship, Drug; Gene Expression; Glucose; Imidazoles; Immunohistochemistry; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Losartan; Male; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Peptidyl-Dipeptidase A; Proinsulin; Protein Biosynthesis; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction | 2004 |
Endogenous angiotensin and pressure modulate brain angiotensinogen and AT1A mRNA expression.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Blood Pressure; Brain Stem; Gene Expression; Hypertension; Losartan; Male; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; RNA, Messenger; Solitary Nucleus | 2004 |
[Microalbuminuria is an early marker for increased morbidity and mortality].
Topics: Albuminuria; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biomarkers; Cardiovascular Diseases; Clinical Trials as Topic; Coronary Disease; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Hypertension; Losartan; Male; Meta-Analysis as Topic; Prevalence; Proteinuria; Renin-Angiotensin System; Risk Factors; Stroke | 2003 |
Stimulation of cardiac sympathetic nerve activity by central angiotensinergic mechanisms in conscious sheep.
Topics: Angiotensin II; Animals; Anti-Arrhythmia Agents; Baroreflex; Blood Pressure; Female; Ganglionic Blockers; Heart; Heart Rate; Injections, Intraventricular; Kidney; Losartan; Ovariectomy; Phenylephrine; Sheep; Sympathetic Nervous System; Sympathomimetics | 2004 |
Angiotensin II stimulates DNA synthesis of rat pancreatic stellate cells by activating ERK through EGF receptor transactivation.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blotting, Western; DNA; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Losartan; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Pancreas; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Recombinant Proteins; Thymidine; Transcriptional Activation; Tritium | 2004 |
Role of angiotensin II in ischemia/reperfusion-induced leukocyte-endothelium interactions in the colon.
Topics: Allopurinol; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Capillaries; Captopril; Cell Adhesion; Chemokines; Chemotaxis, Leukocyte; Colon; Constriction; Disease Models, Animal; Endothelium, Vascular; Enzyme Induction; Gene Expression Regulation; Inflammation; Ischemia; Leukocyte Count; Leukocytes; Losartan; Male; Mesenteric Artery, Superior; Mice; Mice, Inbred C57BL; Mice, Knockout; P-Selectin; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase | 2004 |
Cerebral ischemia enhances vascular angiotensin AT1 receptor-mediated contraction in rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Brain Ischemia; Culture Techniques; Infarction, Middle Cerebral Artery; Losartan; Male; Middle Cerebral Artery; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; RNA, Messenger; Tetrazoles; Vasoconstriction; Vasoconstrictor Agents | 2004 |
Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Carboxypeptidases; Cardiomyopathy, Hypertrophic; Coronary Vessels; Disease Models, Animal; Enzyme Induction; Imidazoles; Ligation; Losartan; Male; Myocardial Infarction; Myocardium; Olmesartan Medoxomil; Peptide Fragments; Peptidyl-Dipeptidase A; Pyridines; Rats; Rats, Inbred Lew; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; RNA, Messenger; Tetrazoles; Ventricular Remodeling | 2004 |
Connective tissue growth factor--a novel mediator of angiotensin II-stimulated cardiac fibroblast activation in heart failure in rats.
Topics: Administration, Oral; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Arrhythmia Agents; Cardiac Output, Low; Cells, Cultured; Connective Tissue Growth Factor; Fibroblasts; Gene Expression; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Losartan; Male; Myocardial Infarction; Myocardium; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; RNA, Messenger; Vasoconstrictor Agents | 2004 |
Effect of angiotensin II and endothelin-1 receptor blockade on the haemodynamic and hormonal changes after acute blood loss and after retransfusion in conscious dogs.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Atrasentan; Blood Pressure; Blood Transfusion; Cardiac Output; Dogs; Endothelin-1; Epinephrine; Female; Glomerular Filtration Rate; Hemodynamics; Hemorrhage; Losartan; Norepinephrine; Pyrrolidines; Receptor, Endothelin A; Stroke Volume; Urine; Vascular Resistance; Vasopressins | 2004 |
Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells.
Topics: Angiotensin II; Cells, Cultured; Codon; Culture Media, Serum-Free; Endothelial Cells; Endothelium, Vascular; Glucose; Humans; Insulin; Insulin Receptor Substrate Proteins; JNK Mitogen-Activated Protein Kinases; Losartan; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Angiotensin, Type 1; Signal Transduction; Umbilical Veins | 2004 |
Nitric oxide and angiotensin II: neuromodulation of thermoregulation during combined heat and hypohydration stress.
Topics: Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Blotting, Western; Body Temperature; Body Temperature Regulation; Body Weight; Cell Membrane; Cell Nucleus; Dehydration; Drug Interactions; Enzyme Inhibitors; Heat Stress Disorders; Indazoles; Injections, Intraventricular; Losartan; Male; Nitric Oxide; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Salivation; Vasodilation | 2004 |
Tonic angiotensinergic inputs to neurons in the anterior hypothalamic area of rats.
Topics: Acetylcholine; Action Potentials; Adrenergic alpha-Agonists; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Animals; Anterior Hypothalamic Nucleus; Anti-Arrhythmia Agents; Captopril; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Imidazoles; Losartan; Male; Muscarinic Antagonists; Neurons; Phenylephrine; Pyridines; Rats; Rats, Wistar; Scopolamine | 2004 |
Evidence of the role of angiotensin AT(1) receptors in remote renal preconditioning of myocardium.
Topics: Angiotensin II; Animals; Blood Pressure; Body Temperature; Coronary Vessels; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Heart Rate; Injections, Intravenous; Ischemia; Ischemic Preconditioning, Myocardial; Kidney; Losartan; Male; Myocardial Infarction; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renal Artery; Reperfusion; Time Factors | 2004 |
Angiotensins II and IV stimulate the rat anterior pituitary cell proliferation independently of the AT1 receptor subtype.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Cell Division; Female; Losartan; Pituitary Gland, Anterior; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Vasoconstrictor Agents | 2003 |
Renal expression of COX-2, ANG II, and AT1 receptor in remnant kidney: strong renoprotection by therapy with losartan and a nonsteroidal anti-inflammatory.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Cyclooxygenase 2; Drug Therapy, Combination; Flurbiprofen; Hypertension, Renal; Immunohistochemistry; Isoenzymes; Kidney; Kidney Diseases; Losartan; Male; Nephrectomy; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1 | 2004 |
Angiotensin IV stimulates the activity of tyrosine kinases in rat anterior pituitary gland acting via AT1-like receptors?
Topics: Angiotensin II; Animals; Dose-Response Relationship, Drug; Drug Antagonism; Drug Combinations; Losartan; Male; Pituitary Gland, Anterior; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Time Factors | 2004 |
Fingernail clubbing and chromonychia associated with the use of angiotensin II receptor blockers.
Topics: Aged; Angiotensin II; Angiotensin Receptor Antagonists; Fingers; Humans; Hypertension; Losartan; Male; Nail Diseases; Toes | 2004 |
Local actions of endogenous angiotensin II in injured glomeruli.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Cell Division; DNA, Antisense; Genetic Therapy; Glomerular Mesangium; Glomerulonephritis; Isoantibodies; Kidney Glomerulus; Losartan; Male; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Transfection | 2004 |
Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development: a possible role for angiotensin-converting enzyme and the receptors for angiotensin II and aldosterone.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Aortic Diseases; Apolipoproteins E; Arteriosclerosis; Cell Line; Enzyme Induction; Eplerenone; Hormone Antagonists; Humans; Lipid Peroxidation; Lipoproteins, LDL; Losartan; Macrophages, Peritoneal; Membrane Proteins; Mice; Mice, Knockout; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Oxidative Stress; Peptidyl-Dipeptidase A; Phosphoproteins; Protein Transport; Ramipril; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; RNA, Messenger; Spironolactone; Superoxides | 2004 |
Stimulation of cyclic GMP production via AT2 and B2 receptors in the pressure-overloaded aorta after banding.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Valve Stenosis; Bradykinin; Bradykinin B2 Receptor Antagonists; Cyclic GMP; Hypertension; Imidazoles; Ligation; Losartan; Male; Mice; Mice, Inbred ICR; Models, Animal; Nitric Oxide; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptor, Bradykinin B2; Renin; RNA, Messenger; Up-Regulation; Vasoconstriction | 2004 |
Aspirin, superoxide anions and development of hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Aorta; Aspirin; Cells, Cultured; Hypertension; Losartan; Luminescent Measurements; Male; Muscle, Smooth, Vascular; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxides; Time Factors; Vasoconstrictor Agents | 2004 |
Prevention of angiotensin II-induced hypertension, cardiovascular hypertrophy and oxidative stress by acetylsalicylic acid in rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Aorta; Aspirin; Body Weight; Cells, Cultured; Hypertension; Hypertrophy, Left Ventricular; Losartan; Luminescent Measurements; Male; Muscle, Smooth, Vascular; Organ Size; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxides; Time Factors; Vasoconstrictor Agents | 2004 |
Angiotensin II stimulates phosphorylation of 4E-binding protein 1 and p70 S6 kinase in cultured vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Carrier Proteins; Cells, Cultured; Chromones; Intracellular Signaling Peptides and Proteins; Losartan; Morpholines; Muscle, Smooth, Vascular; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction | 2004 |
Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor.
Topics: Angiotensin II; Animals; Anthracenes; Blotting, Western; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Flavonoids; Genistein; Imidazoles; Kidney; Losartan; Mice; Microscopy, Fluorescence; Onium Compounds; PAX2 Transcription Factor; Phosphorylation; Plasmids; Pyridines; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transcription Factors; Tyrphostins; Up-Regulation | 2004 |
Inhibitory effects of angiotensin on NMDA-induced cytotoxicity in primary neuronal cultures.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Apoptosis; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Glutamic Acid; In Situ Nick-End Labeling; Losartan; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents | 2004 |
Central AII evokes a normal sodium appetite in the Fischer rat, but its low spontaneous sodium intake may be related to reduced excitation and increased inhibition in septo-preoptic AII neurons.
Topics: Action Potentials; Angiotensin II; Animals; Antihypertensive Agents; Appetite Regulation; Brain; Electrophysiology; Injections, Intraventricular; Losartan; Male; Microelectrodes; Neurons; Rats; Rats, Inbred F344; Rats, Wistar; Sodium | 2004 |
Pharmacological properties of angiotensin II receptors in cultured rabbit gingival fibroblasts.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Binding, Competitive; Biphenyl Compounds; Blotting, Western; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblasts; Gingiva; Kinetics; Losartan; Rabbits; Radioligand Assay; Receptors, Angiotensin; Saralasin; Tetrazoles; Tritium | 2004 |
Evidence of a novel intracrine mechanism in angiotensin II-induced cardiac hypertrophy.
Topics: Adenoviridae; Angiotensin II; Animals; Anti-Arrhythmia Agents; Blood Pressure; Cell Membrane; Cytoskeleton; DNA Primers; Gene Expression Regulation; Insulin-Like Growth Factor I; Losartan; Mice; Myocytes, Cardiac; Rats; Receptor, Angiotensin, Type 1; Transforming Growth Factor beta; Vasoconstrictor Agents | 2004 |
Angiotensin II and angiotensin-(1-7) inhibit the inner cortex Na+ -ATPase activity through AT2 receptor.
Topics: Adjuvants, Immunologic; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Antihypertensive Agents; Cholera Toxin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Imidazoles; Kidney Cortex; Losartan; Peptide Fragments; Pertussis Toxin; Pyridines; Receptor, Angiotensin, Type 2; Sodium-Potassium-Exchanging ATPase; Swine; Vasoconstrictor Agents | 2004 |
Angiotensin II-induced relaxation of anococcygeus smooth muscle via desensitization of AT1 receptor, and activation of AT2 receptor associated with nitric-oxide synthase pathway.
Topics: Adenine; Angiotensin II; Animals; Blotting, Western; CD13 Antigens; Drug Interactions; Glutamyl Aminopeptidase; Imidazoles; Losartan; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptide Fragments; Peptides; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrodotoxin; Thiorphan | 2004 |
Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system.
Topics: Adenoviridae; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Brain Chemistry; Cardiomegaly; Genetic Therapy; Genetic Vectors; Humans; Hypertension; Infusion Pumps, Implantable; Infusions, Parenteral; Injections, Intraventricular; Isoenzymes; Losartan; Mice; Mice, Inbred C57BL; Myocardium; Organ Size; Oxidation-Reduction; Oxidative Stress; Recombinant Fusion Proteins; Subfornical Organ; Superoxide Dismutase; Superoxides | 2004 |
Influence of the 4G/5G PAI-1 genotype on angiotensin II-stimulated human endothelial cells and in patients with hypertension.
Topics: Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Case-Control Studies; Cells, Cultured; Endothelial Cells; Female; Fibrinolysis; Genetic Markers; Genotype; Humans; Hypertension; Losartan; Male; Middle Aged; Plasminogen Activator Inhibitor 1; Polymorphism, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Statistics, Nonparametric; Stimulation, Chemical | 2004 |
Differential response of human cardiac fibroblasts to angiotensin I and angiotensin II.
Topics: Angiotensin I; Angiotensin II; Captopril; Cell Line; Collagen; Fibroblasts; Humans; Losartan; Myocardium; Peptidyl-Dipeptidase A | 2004 |
Angiotensinergic pathway through the median preoptic nucleus in the control of oxytocin secretion and water and sodium intake.
Topics: Angiotensin II; Animals; Losartan; Male; Oxytocin; Preoptic Area; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Sodium, Dietary; Water | 2004 |
Effect of angiotensin II and losartan on the phagocytic activity of peritoneal macrophages from Balb/C mice.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Losartan; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Phagocytosis; Vasoconstrictor Agents | 2004 |
Angiotensin II induces carbon monoxide production in the perfused kidney: relationship to protein kinase C activation.
Topics: Angiotensin II; Animals; Blood Pressure; Carbon Monoxide; Enzyme Activation; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); In Vitro Techniques; Isoenzymes; Kidney; Losartan; Male; Perfusion; Protein Kinase C; Rats; Rats, Sprague-Dawley; Renal Circulation; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents | 2004 |
Renal nitric oxide production is decreased in diabetic rats and improved by AT1 receptor blockade.
Topics: Albuminuria; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Extracellular Fluid; Kidney; Losartan; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Tetrazoles; Valine; Valsartan | 2004 |
Effect of chronic stress on the cardiac baroreflex in the post-weanling rat.
Topics: Age Factors; Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Baroreflex; Blood Pressure; Catheterization; Corticotropin-Releasing Hormone; Gene Expression Regulation; Heart Rate; In Situ Hybridization; Losartan; Male; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Restraint, Physical; RNA, Messenger; Stress, Physiological; Weaning | 2004 |
Pressor effects of electrical stimulation of medial prefrontal cortex in unanesthetized rats.
Topics: Adrenal Medulla; Angiotensin II; Animals; Autonomic Pathways; Blood Pressure; Denervation; Efferent Pathways; Electric Stimulation; Electrodes, Implanted; Ganglia, Sympathetic; Losartan; Male; Mecamylamine; Prefrontal Cortex; Rats; Rats, Wistar; Sympathetic Nervous System; Urethane; Vasoconstriction; Vasopressins; Wakefulness | 2004 |
Central Tempol alters basal sympathetic nerve discharge and attenuates sympathetic excitation to central ANG II.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Blood Pressure; Brain; Cyclic N-Oxides; Drug Interactions; Heart Rate; Hot Temperature; Injections, Intraventricular; Losartan; Rats; Rats, Sprague-Dawley; Spin Labels; Superoxides; Sympathetic Nervous System; Vasoconstrictor Agents | 2004 |
Intracellular and extracellular angiotensin II enhance the L-type calcium current in the failing heart.
Topics: Adenosine Triphosphatases; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Animals; Calcium Channels, L-Type; Calcium Signaling; Cardiomyopathies; Cells, Cultured; Cricetinae; Enalaprilat; Enzyme Activation; Extracellular Fluid; Intracellular Fluid; Losartan; Male; Mesocricetus; Myocytes, Cardiac; Protein Kinase C; Sarcoplasmic Reticulum; Staurosporine; Thapsigargin | 2004 |
Effect of endogenous angiotensin II on the frequency response of the renal vasculature.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Flow Velocity; Blood Pressure; Diet, Sodium-Restricted; Electric Stimulation; Kidney; Kinetics; Losartan; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Sympathetic Nervous System; Vascular Resistance | 2004 |
Contribution of angiotensin II to alcohol-induced pancreatic fibrosis in rats.
Topics: Actins; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Body Weight; Captopril; Central Nervous System Depressants; Collagen; Cytokines; Ethanol; Fibrosis; Immunohistochemistry; Losartan; Male; Pancreas; Pancreatic Diseases; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Ribonucleases; RNA, Messenger | 2004 |
Down-regulation of inositol 1,4,5-trisphosphate receptor in cells stably expressing the constitutively active angiotensin II N111G-AT(1) receptor.
Topics: Angiotensin II; Antihypertensive Agents; Calcium; Calcium Channels; Calcium Signaling; Cell Line; Down-Regulation; Embryo, Mammalian; Humans; Imidazoles; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Kidney; Losartan; Receptor, Angiotensin, Type 1; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Tetrazoles; Thapsigargin | 2004 |
Angiotensin II attenuates NMDA receptor-mediated neuronal cell death and prevents the associated reduction in Bcl-2 expression.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Death; Cell Line; Cell Survival; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Imidazoles; Losartan; N-Methylaspartate; Neurons; Proto-Oncogene Proteins c-bcl-2; Pyridines; Receptors, Angiotensin; Receptors, N-Methyl-D-Aspartate; Vasoconstrictor Agents | 2004 |
Effect of angiotensin II type 1 receptor on delayed rectifier potassium current in catecholaminergic CATH.a cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Catecholamines; Cell Line; Delayed Rectifier Potassium Channels; Imidazoles; Locus Coeruleus; Losartan; Mice; Naphthalenes; Potassium Channels, Voltage-Gated; Protein Kinase C; Pyridines; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Signal Transduction; Sulfonamides; Type C Phospholipases | 2004 |
Pressor response to CSF sodium in mice: mediation by a ouabain-like substance and renin-angiotensin system in the brain.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cardiotonic Agents; Heart Rate; Humans; Immunoglobulin Fab Fragments; Injections, Intraventricular; Losartan; Male; Mice; Ouabain; Renin-Angiotensin System; Sodium; Sodium Chloride | 2004 |
Profibrotic influence of high glucose concentration on cardiac fibroblast functions: effects of losartan and vitamin E.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Cells, Cultured; Collagen Type I; Dose-Response Relationship, Drug; Fibroblasts; Fibrosis; Glucose; Leucine; Losartan; Male; Matrix Metalloproteinases; Myocardium; Osmolar Concentration; Proline; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; RNA, Messenger; Vitamin E | 2005 |
Angiotensin II-dependent induction of AT(2) receptor expression after renal ablation.
Topics: Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Blood Pressure; Diuresis; Gene Expression Regulation; Imidazoles; Kidney; Ligation; Losartan; Male; Nephrectomy; Proteinuria; Pyridines; Ramipril; Rats; Rats, Wistar; Receptor, Angiotensin, Type 2; Renal Artery; RNA, Messenger | 2005 |
Changes in skeletal muscle SR Ca2+ pump in congestive heart failure due to myocardial infarction are prevented by angiotensin II blockade.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Apoptosis; Calcium; Calcium-Transporting ATPases; Captopril; Cyclic AMP-Dependent Protein Kinases; Enalapril; Heart Failure; Imidazolidines; Losartan; Male; Muscle, Skeletal; Muscular Atrophy; Myocardial Infarction; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum; Time Factors | 2004 |
Angiotensin II receptor modulation of renal vascular resistance and neurotransmission in young and adult spontaneously hypertensive rats.
Topics: Aging; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Imidazoles; Kidney; Losartan; Male; Norepinephrine; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WF; Receptor, Angiotensin, Type 1; Signal Transduction; Sympathetic Nervous System; Tetrazoles; Vascular Resistance; Vasoconstrictor Agents | 2005 |
Superoxide mediates sympathoexcitation in heart failure: roles of angiotensin II and NAD(P)H oxidase.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Ditiocarb; Heart Failure; Heart Rate; Injections, Intraventricular; Kidney; Losartan; Male; Medulla Oblongata; NADPH Oxidases; Protein Subunits; Rabbits; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; RNA, Messenger; Superoxides; Sympathetic Nervous System; Tachycardia, Ventricular; Telemetry | 2004 |
Induced fetal depressor or pressor responses associated with c-fos by intravenous or intracerebroventricular losartan.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Brain; Cardiovascular System; Cattle; Dose-Response Relationship, Drug; Female; Fetus; Genes, fos; Heart Rate; Immunohistochemistry; Injections, Intravenous; Injections, Intraventricular; Losartan; Pregnancy; Renin-Angiotensin System | 2004 |
Oxidant stress in kidneys of spontaneously hypertensive rats involves both oxidase overexpression and loss of extracellular superoxide dismutase.
Topics: Acetophenones; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Bradykinin; Enalaprilat; Free Radical Scavengers; Immunoblotting; In Vitro Techniques; Kidney; Kidney Cortex; Losartan; NADPH Oxidases; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxidative Stress; Oxygen Consumption; Rats; Rats, Inbred SHR; Rats, Inbred WKY; S-Nitroso-N-Acetylpenicillamine; Superoxide Dismutase | 2004 |
ANG II in the paraventricular nucleus potentiates the cardiac sympathetic afferent reflex in rats with heart failure.
Topics: Angiotensin II; Animals; Arteries; Cardiac Output, Low; Chronic Disease; Coronary Vessels; Dose-Response Relationship, Drug; Electric Stimulation; Heart; Hemodynamics; Kidney; Ligation; Losartan; Male; Microinjections; Neurons, Afferent; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Reflex; Sympathetic Nervous System; Vasoconstrictor Agents | 2004 |
Ouabain at nanomolar concentration promotes synthesis and release of angiotensin II from the endothelium of the tail vascular bed of spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Blood Pressure; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Enalaprilat; Endothelium, Vascular; Glucose; Hexamethonium; Injections, Intravenous; Losartan; Male; Muscle, Smooth, Vascular; Ouabain; Perfusion; Phenylephrine; Potassium Chloride; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium-Potassium-Exchanging ATPase; Tail; Time Factors; Tromethamine; Vasodilation | 2004 |
Salt-induced ANG II suppression impairs the response of cerebral artery smooth muscle cells to prostacyclin.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Calcium; Cerebral Arteries; Epoprostenol; Hypertension; Iloprost; Losartan; Male; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Serotonin; Sodium Chloride; Vasodilation; Vasodilator Agents | 2005 |
Angiotensin II regulation of TGF-beta in murine mesangial cells involves both PI3 kinase and MAP kinase.
Topics: Angiotensin II; Animals; Butadienes; Cell Line; Chromones; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Epidermal Growth Factor; Glomerular Mesangium; Immunoblotting; Losartan; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Tyrphostins | 2004 |
Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetophenones; Amino Acid Sequence; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arterioles; Cerebrovascular Circulation; Cytochromes b; Endothelium, Vascular; Free Radical Scavengers; Free Radicals; Glycoproteins; Hypercapnia; Hyperemia; Hypertension; Laser-Doppler Flowmetry; Losartan; Male; Membrane Glycoproteins; Metalloporphyrins; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Muscle, Smooth, Vascular; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide Donors; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; S-Nitroso-N-Acetylpenicillamine; Somatosensory Cortex; Superoxide Dismutase; Vibrissae | 2004 |
Angiotensin II mediates acinar cell apoptosis during the development of rat pancreatic fibrosis by AT1R.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Disease Models, Animal; Fibrosis; Gene Expression Regulation; In Situ Nick-End Labeling; Losartan; Male; Pancreas; Pancreatic Ducts; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid | 2004 |
Losartan inhibited expression of matrix metalloproteinases in rat atherosclerotic lesions and angiotensin II-stimulated macrophages.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arteriosclerosis; Cells, Cultured; Dose-Response Relationship, Drug; Losartan; Macrophages, Peritoneal; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Rats; Rats, Inbred WKY; RNA, Messenger | 2004 |
AT1 receptor in rostral ventrolateral medulla mediating blunted baroreceptor reflex in spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Baroreflex; Blood Pressure; Heart Rate; Hypertension; Losartan; Male; Medulla Oblongata; Oligodeoxyribonucleotides, Antisense; Phenylephrine; Rats; Rats, Inbred SHR; Rats, Wistar; Receptor, Angiotensin, Type 1 | 2004 |
Role of angiotensin in body fluid homeostasis of mice: effect of losartan on water and NaCl intakes.
Topics: Angiotensin II; Animals; Appetite; Body Fluids; Brain; Diet, Sodium-Restricted; Drinking; Homeostasis; Hypovolemia; Injections, Intraventricular; Injections, Subcutaneous; Losartan; Male; Mice; Mice, Inbred ICR; Polyethylene Glycols; Proto-Oncogene Proteins c-fos; Sodium Chloride | 2005 |
ACE inhibition lowers angiotensin II-induced chemokine expression by reduction of NF-kappaB activity and AT1 receptor expression.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Cell Line; Chemokine CCL2; Chemokines; Down-Regulation; Drug Interactions; Endothelium, Vascular; Humans; Imidazoles; Interleukin-8; Losartan; Monocytes; NF-kappa B; Peptidyl-Dipeptidase A; Pyridines; Ramipril; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Simvastatin; Umbilical Veins | 2004 |
Transforming growth factor beta receptor endoglin is expressed in cardiac fibroblasts and modulates profibrogenic actions of angiotensin II.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Antibodies, Monoclonal; Benzimidazoles; Biphenyl Compounds; Cells, Cultured; Collagen Type I; Endoglin; Fibroblasts; Flavonoids; Gene Expression Regulation; Imidazoles; Intracellular Signaling Peptides and Proteins; Losartan; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Myocardium; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Transforming Growth Factor beta; RNA, Messenger; Signal Transduction; Tetrazoles; Valine; Valsartan | 2004 |
Oxidative stress in the infarcted heart: role of de novo angiotensin II production.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Heart Ventricles; Losartan; Male; Myocardial Infarction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tissue Distribution; Treatment Outcome | 2004 |
Central angiotensin II AT1 receptors mediate fetal swallowing and pressor responses in the near-term ovine fetus.
Topics: Angiotensin II; Animals; Anti-Arrhythmia Agents; Blood Gas Analysis; Blood Pressure; Brain Chemistry; Deglutition; Drinking; Electromyography; Female; Fetus; Imidazoles; Losartan; Pregnancy; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sheep | 2005 |
Blood pressure maintenance in NHE3-deficient mice with transgenic expression of NHE3 in small intestine.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Homeostasis; Intestine, Small; Losartan; Mice; Mice, Knockout; Mice, Transgenic; Natriuresis; Renal Circulation; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sodium, Dietary | 2005 |
Potentiation by angiotensin II of spontaneous excitatory postsynaptic currents in rat supraoptic magnocellular neurones.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Long-Term Potentiation; Losartan; Male; Neural Inhibition; Neurons; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, Glutamate; Supraoptic Nucleus | 2004 |
Reactive oxygen species blockade and action of insulin on expression of angiotensinogen gene in proximal tubular cells.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Azaserine; Cell Line; Gene Expression Regulation; Glucose; Imidazoles; Indicators and Reagents; Indoles; Insulin; Kidney Tubules, Proximal; Losartan; Maleimides; Perindopril; Protein Kinase C; Pyridines; Rats; Reactive Oxygen Species; Renin | 2004 |
Inhibition of catecholamine-induced cardiac fibrosis by an aldosterone antagonist.
Topics: Adrenergic beta-Agonists; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Canrenoic Acid; Fibrosis; Heart Failure; Isoproterenol; Losartan; Male; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Myocardium; Rats; Rats, Wistar; Receptors, Adrenergic, beta | 2005 |
Hemodynamic and metabolic effects of angiotensin II on the liver.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Captopril; Dose-Response Relationship, Drug; Hemodynamics; Hepatocytes; Kinetics; Kupffer Cells; Liver; Liver Circulation; Losartan; Male; Oxygen Consumption; Perfusion; Rats; Rats, Wistar | 2005 |
Sympathoexcitation by central ANG II: roles for AT1 receptor upregulation and NAD(P)H oxidase in RVLM.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Baroreflex; Kidney; Losartan; Male; Medulla Oblongata; NADPH Oxidases; Rabbits; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; RNA, Messenger; Sympathetic Nervous System; Vasoconstrictor Agents | 2005 |
Angiotensin II-mediated calcium signals and mitogenesis in human prostate stromal cell line hPCPs.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Blotting, Western; Buffers; Calcium; Calcium Signaling; Cell Line; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Fluorescent Dyes; Fura-2; Humans; Immunohistochemistry; Intracellular Fluid; Isotonic Solutions; Losartan; Male; Mitosis; Photometry; Prostatic Hyperplasia; Receptor, Angiotensin, Type 1; Ringer's Solution; Stromal Cells; Time Factors | 2005 |
Angiotensin II inhibition of Ca2+ currents is independent of ATR1 angiotensin II receptor activation in rat adult vagal afferent neurons.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Drug Interactions; Losartan; Membrane Potentials; Neural Inhibition; Neurons, Afferent; Nifedipine; Nodose Ganglion; Patch-Clamp Techniques; Rats; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Saralasin | 2005 |
Pharmacological concentration of angiotensin-(1-7) activates NADPH oxidase after ischemia-reperfusion in rat heart through AT1 receptor stimulation.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Enzyme Activation; Heart; In Vitro Techniques; Losartan; Male; Myocardial Ischemia; Myocardium; NADPH Oxidases; Peptide Fragments; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Reperfusion | 2005 |
Intracisternal galanin/angiotensin II interactions in central cardiovascular control.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cardiovascular System; Galanin; Heart Rate; Losartan; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Swine | 2005 |
Protein kinase C-mediated inhibition of renal Ca2+ ATPase by physiological concentrations of angiotensin II is reversed by AT1- and AT2-receptor antagonists.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Calcium-Transporting ATPases; Cells, Cultured; Dose-Response Relationship, Drug; Imidazoles; Kidney Tubules, Proximal; Losartan; Protein Kinase C; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sheep; Vasoconstrictor Agents | 2005 |
Evidence for a functional cardiac interaction between losartan and angiotensin-(1-7) receptors revealed by orthostatic tilting test in rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Bradycardia; Cardiovascular System; Hypotension, Orthostatic; Losartan; Male; Peptide Fragments; Rats; Rats, Wistar; Time Factors | 2005 |
Pulmonary hypertension during epileptic seizure with evidence of increased angiotensin II in pulmonary artery.
Topics: Aged; Angiotensin II; Anticonvulsants; Catheterization, Swan-Ganz; Drug Therapy, Combination; Epilepsy; Follow-Up Studies; Humans; Hypertension, Pulmonary; Losartan; Male; Pulmonary Artery; Pulmonary Circulation; Risk Assessment; Severity of Illness Index; Treatment Outcome | 2005 |
Angiotensin II enhances insulin sensitivity in vitro and in vivo.
Topics: Adipocytes; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Drug Synergism; Gene Expression; Glucose; Glucose Tolerance Test; Glucose Transporter Type 4; Insulin; Insulin Resistance; Losartan; Male; Monosaccharide Transport Proteins; Muscle Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptor, Insulin; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2005 |
Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Adenoviridae; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Aorta; Cell Line, Transformed; Coronary Vessels; Gene Expression Profiling; Gene Expression Regulation; Genes, Reporter; Genetic Vectors; Humans; Hydrocortisone; Losartan; Mammary Tumor Virus, Mouse; Models, Biological; Muscle, Smooth, Vascular; Myocardial Ischemia; Myocytes, Smooth Muscle; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Spironolactone; Transcription, Genetic; Transduction, Genetic | 2005 |
The renin-angiotensin system and the developing retinal vasculature.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Animals, Genetically Modified; Autoradiography; Immunoenzyme Techniques; Lisinopril; Losartan; Neovascularization, Physiologic; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin; Renin-Angiotensin System; Retinal Ganglion Cells; Retinal Vessels | 2005 |
Role of the renin-angiotensin system on the parathyroid hormone-related protein overexpression induced by nephrotoxic acute renal failure in the rat.
Topics: Acute Kidney Injury; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Line; Enalapril; Folic Acid; Gentamicins; Kidney; Kidney Tubules; Losartan; Male; Parathyroid Hormone-Related Protein; Quinapril; Rats; Rats, Wistar; Receptor, Parathyroid Hormone, Type 1; Renin-Angiotensin System; Tetrahydroisoquinolines | 2005 |
Sympathetic modulation by carvedilol and losartan reduces angiotensin II-mediated lipolysis in subcutaneous and visceral fat.
Topics: Adipocytes; Adipose Tissue; Angiotensin II; Animals; Blood Pressure; Body Weight; Carbazoles; Carvedilol; Glycerol; Heart Rate; Lipolysis; Losartan; Male; Norepinephrine; Propanolamines; Rats; Rats, Sprague-Dawley; Sterol Esterase; Sympathetic Nervous System; Triglycerides; Tyrosine 3-Monooxygenase | 2005 |
NAD(P)H oxidase inhibition attenuates neuronal chronotropic actions of angiotensin II.
Topics: Action Potentials; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Brain Stem; Calcium Signaling; Catalase; Cells, Cultured; Cyclic N-Oxides; Delayed Rectifier Potassium Channels; Drinking Behavior; Glycoproteins; Heart Rate; Hypothalamus; Imidazoles; Injections, Intraventricular; Ion Channel Gating; Losartan; Male; NADPH Oxidases; Neurons; Polyethylene Glycols; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Inbred WKY; Reactive Oxygen Species; Spin Labels; Telemetry; Xanthine; Xanthine Oxidase | 2005 |
Effect of high glucose on superoxide in human mesangial cells: role of angiotensin II.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Biphenyl Compounds; Cell Culture Techniques; Diabetic Nephropathies; Glucose; Humans; Irbesartan; Kidney Glomerulus; Losartan; Oxidants; Superoxide Dismutase; Superoxides; Tetrazoles | 2005 |
Interaction of central Ang II and NO on the cardiac sympathetic afferent reflex in dogs.
Topics: Afferent Pathways; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Citrulline; Dogs; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Administration Routes; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Female; Heart; Heart Rate; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Reflex; Sympathectomy; Sympathetic Nervous System; Thiourea; Time Factors; Vagotomy | 2005 |
Comparison of 3 AT1 receptor binding assays: filtration assay, ScreenReady Target, and WGA Flashplate.
Topics: Angiotensin II; Animals; Binding, Competitive; CHO Cells; Cricetinae; Filtration; Ligands; Losartan; Protein Binding; Receptor, Angiotensin, Type 1; Thermodynamics; Wheat Germ Agglutinins | 2005 |
A new role for the renin-angiotensin system in the rat periaqueductal gray matter: angiotensin receptor-mediated modulation of nociception.
Topics: Anesthetics, Local; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Dose-Response Relationship, Drug; Immunohistochemistry; Lidocaine; Losartan; Male; Nociceptors; Oligopeptides; Pain Measurement; Periaqueductal Gray; Rats; Rats, Wistar; Reaction Time; Receptors, Angiotensin; Renin-Angiotensin System; Time Factors | 2005 |
Angiotensin II stimulates arachidonic acid release from bone marrow stromal cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Arachidonic Acid; Bone Marrow Cells; Cells, Cultured; Humans; Imidazoles; Losartan; Macaca fascicularis; Macrophage Colony-Stimulating Factor; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Stromal Cells | 2004 |
Suppressors of cytokine signaling regulate angiotensin II-activated Janus kinase-signal transducers and activators of transcription pathway in renal cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cells, Cultured; Cytokines; DNA-Binding Proteins; Epithelial Cells; Humans; Intracellular Signaling Peptides and Proteins; Janus Kinase 2; Kidney; Losartan; Mice; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Repressor Proteins; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Transcription Factors; Transcriptional Activation | 2005 |
Differential effects of angiotensin II on atherogenesis at the aortic sinus and descending aorta of apolipoprotein-E-deficient mice.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta, Thoracic; Aortic Diseases; Apolipoproteins E; Arteriosclerosis; Female; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Sinus of Valsalva | 2005 |
Angiotensin II type 2 receptors contribute to vascular responses in spontaneously hypertensive rats treated with angiotensin II type 1 receptor antagonists.
Topics: Acetylcholine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Blood Pressure; Endothelium, Vascular; Heart Rate; Hypertension; Losartan; Male; Nitric Oxide; Nitroprusside; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Vasoconstriction; Vasodilation | 2005 |
Angiotensin depolarizes parvocellular neurons in paraventricular nucleus through modulation of putative nonselective cationic and potassium conductances.
Topics: Angiotensin II; Animals; Cations; Electrophysiology; In Vitro Techniques; Ion Channels; Losartan; Male; Neurons; Neurosecretory Systems; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 2005 |
ATR blockade reduces IFN-gamma production in lymphocytes in vivo and in vitro.
Topics: Adult; Aged; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biphenyl Compounds; Female; Humans; Interferon-gamma; Losartan; Lymphocyte Activation; Lymphocytes; Male; Middle Aged; Polymerase Chain Reaction; RNA, Messenger; Tetrazoles | 2005 |
Angiotensin II dilates bovine adrenal cortical arterioles: role of endothelial nitric oxide.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenal Cortex; Angiotensin II; Animals; Arterioles; Cattle; Endothelium, Vascular; Losartan; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2005 |
The constitutively active N111G-AT1 receptor for angiotensin II modifies the morphology and cytoskeletal organization of HEK-293 cells.
Topics: Angiotensin II; Cell Line; Cell Shape; Cytoskeleton; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Losartan; Mutation; Phenotype; Protein Serine-Threonine Kinases; Receptor, Angiotensin, Type 1; rho-Associated Kinases; Tetrazoles | 2005 |
Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Carboxypeptidases; Gene Expression Regulation; Lisinopril; Losartan; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Rats, Inbred Lew; RNA, Messenger | 2005 |
Angiotensin II subtype 1 receptor blockade inhibits Clostridium difficile toxin A-induced intestinal secretion in a rabbit model.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Bacterial Toxins; Clostridioides difficile; Dose-Response Relationship, Drug; Enterotoxins; Ileitis; Intestinal Mucosa; Losartan; Rabbits | 2005 |
Angiotensin II protects cultured midbrain dopaminergic neurons against rotenone-induced cell death.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Cell Death; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Insecticides; Losartan; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra; Tyrosine 3-Monooxygenase | 2005 |
The effect of angiotensin III on protein tyrosine kinase activity in rat pituitary.
Topics: Angiotensin II; Angiotensin III; Animals; CD13 Antigens; Imidazoles; Losartan; Methionine; Peptides; Pituitary Gland; Protein Binding; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2 | 2005 |
Tubular expression of angiotensin II receptors and their regulation in IgA nephropathy.
Topics: Angiotensin II; Apoptosis; Cells, Cultured; Culture Media, Conditioned; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Epithelial Cells; Gene Expression Regulation; Glomerulonephritis, IGA; Humans; Imidazoles; Immunoblotting; Immunoglobulin A; Immunohistochemistry; Inflammation; Interleukin-6; Kidney Diseases; Kidney Glomerulus; Kidney Tubules; Kinetics; Losartan; MAP Kinase Signaling System; Mesangial Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Poly(ADP-ribose) Polymerases; Protein Kinase C; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Recombinant Proteins; Renin-Angiotensin System; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha; Up-Regulation | 2005 |
Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage.
Topics: Adrenal Glands; Adrenalectomy; Aldosterone; Angiotensin II; Angiotensinogen; Animals; Animals, Genetically Modified; Cytochrome P-450 CYP11B2; Enzyme Inhibitors; Fibrosis; Heart Diseases; Humans; Inflammation; Kidney Diseases; Losartan; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Renin | 2005 |
ANG II increases 2-deoxyglucose uptake in mouse embryonic stem cells.
Topics: Alkaline Phosphatase; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biological Transport; Calcimycin; Calcium; Cell Line; Cell Proliferation; Deoxyglucose; DNA-Binding Proteins; Dose-Response Relationship, Drug; Embryo, Mammalian; Estrenes; Gene Expression; Glucose Transporter Type 1; Imidazoles; Inositol Phosphates; Losartan; Membrane Transport Proteins; Mice; Monosaccharide Transport Proteins; Neomycin; Octamer Transcription Factor-3; Phosphodiesterase Inhibitors; Protein Kinase C; Pyridines; Pyrrolidinones; Stem Cells; Transcription Factors; Type C Phospholipases; Vasoconstrictor Agents | 2005 |
Angiotensin II induces the expression of tissue factor and its mechanism in human monocytes.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Blood Coagulation; Blood Coagulation Tests; Cells, Cultured; Dose-Response Relationship, Drug; Gene Expression Profiling; Humans; I-kappa B Proteins; Leukocytes, Mononuclear; Losartan; Monocytes; NF-kappa B; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; RNA, Messenger; Signal Transduction; Thromboplastin | 2006 |
Angiotensin II enhances thrombosis development in renovascular hypertensive rats.
Topics: alpha-2-Antiplasmin; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin III; Animals; Blood Pressure; Carotid Arteries; Fibrin; Heart Rate; Hypertension, Renovascular; Infusions, Intravenous; Losartan; Male; Plasminogen Activator Inhibitor 1; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Recombinant Proteins; Regional Blood Flow; Tissue Plasminogen Activator; Venous Thrombosis | 2005 |
Different effects on inhibition of cardiac hypertrophy in spontaneously hypertensive rats by monotherapy and combination therapy of adrenergic receptor antagonists and/or the angiotensin II type 1 receptor blocker under comparable blood pressure reduction
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Atenolol; Blood Pressure; Cardiomegaly; Doxazosin; Drug Therapy, Combination; Echocardiography; Heart Rate; Hypertension; Losartan; Male; Natriuretic Peptide, Brain; Rats; Rats, Inbred SHR; RNA, Messenger | 2005 |
Brain ouabain stimulates peripheral marinobufagenin via angiotensin II signalling in NaCl-loaded Dahl-S rats.
Topics: Adrenal Cortex; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antibodies; Blood Pressure; Brain Chemistry; Bufanolides; Cells, Cultured; Losartan; Male; Natriuresis; Norepinephrine; Ouabain; Pituitary Gland; Rats; Rats, Inbred Dahl; Renin; Sodium Chloride; Sodium-Potassium-Exchanging ATPase; Vasoconstrictor Agents | 2005 |
Oxygen consumption in the kidney: effects of nitric oxide synthase isoforms and angiotensin II.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Energy Metabolism; Enzyme Inhibitors; Glomerular Filtration Rate; Kidney Tubules, Proximal; Losartan; Male; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; omega-N-Methylarginine; Oxygen Consumption; Rats; Rats, Wistar; Renal Circulation; Sodium | 2005 |
Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach.
Topics: ADAM Proteins; ADAM17 Protein; Angiotensin II; Animals; Blotting, Western; DNA Primers; ErbB Receptors; Fluorescent Antibody Technique; Hydroxamic Acids; Immunohistochemistry; Kidney; Kidney Diseases; Losartan; Mice; Mice, Transgenic; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Tumor Necrosis Factor-alpha | 2005 |
Combined angiotensin II type 1 and type 2 receptor blockade on vascular remodeling and matrix metalloproteinases in resistance arteries.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Blotting, Western; Collagen Type I; Elasticity; Elastin; Fibronectins; Hydralazine; Losartan; Male; Matrix Metalloproteinase 2; Mesenteric Artery, Superior; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Vascular Resistance | 2005 |
Role of myofibrillogenesis regulator-1 in myocardial hypertrophy.
Topics: Amino Acid Sequence; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Aortic Valve Stenosis; Cardiomegaly; Cell Size; Losartan; Male; Molecular Sequence Data; Muscle Proteins; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; RNA Interference | 2006 |
Coexpression of AT1 and AT2 receptors by human fibroblasts is associated with resistance to angiotensin II.
Topics: Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Apoptosis; Blotting, Northern; Blotting, Western; Cell Proliferation; Cells, Cultured; Collagen Type I; Culture Media, Serum-Free; Fibroblasts; Gene Expression; Humans; Imidazoles; Losartan; Myocytes, Smooth Muscle; Procollagen; Pyridines; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Vasoconstrictor Agents | 2005 |
Cholinergic stimulation in the posterior hypothalamic nucleus activates angiotensin II-sensitive neurons in the anterior hypothalamic area of rats.
Topics: Acetylcholine; Action Potentials; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Anterior Hypothalamic Nucleus; Carbachol; Cholinergic Agonists; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Hypothalamus, Posterior; Losartan; Male; Microinjections; Muscarinic Antagonists; Neurons; Physostigmine; Rats; Rats, Wistar; Scopolamine; Time Factors | 2005 |
Peripheral sympatholytic actions of four AT1 antagonists: are they relevant for long-term antihypertensive efficacy?
Topics: Acrylates; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Electric Stimulation; Imidazoles; Irbesartan; Losartan; Male; Norepinephrine; Rats; Rats, Inbred SHR; Sympathetic Fibers, Postganglionic; Sympatholytics; Tetrazoles; Thiophenes; Time Factors; Treatment Outcome | 2005 |
NADPH oxidase-derived superoxide anion mediates angiotensin II-induced pressor effect via activation of p38 mitogen-activated protein kinase in the rostral ventrolateral medulla.
Topics: Angiotensin II; Animals; Blood Pressure; Extracellular Signal-Regulated MAP Kinases; Imidazoles; Losartan; Male; Medulla Oblongata; NADPH Oxidases; Oligonucleotides, Antisense; Onium Compounds; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Signal Transduction; Superoxides; Sympathetic Nervous System | 2005 |
Evidence for a functional interaction of the angiotensin-(1-7) receptor Mas with AT1 and AT2 receptors in the mouse heart.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Drug Synergism; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Indomethacin; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; NG-Nitroarginine Methyl Ester; Peptide Fragments; Perfusion; Pressure; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Vasoconstrictor Agents | 2005 |
Low sodium intake induces an increase in renal monoamine oxidase activity in the rat. Involvement of an angiotensin II dependent mechanism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Diet, Sodium-Restricted; Dopamine; Glomerular Filtration Rate; Kidney; Losartan; Male; Monoamine Oxidase; Rats; Rats, Wistar; Sodium | 2005 |
Distinct roles for ANG II and ANG-(1-7) in the regulation of angiotensin-converting enzyme 2 in rat astrocytes.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Antihypertensive Agents; Astrocytes; Carboxypeptidases; Cells, Cultured; Cerebellum; Female; Gene Expression Regulation; Imidazoles; Losartan; Medulla Oblongata; Peptide Fragments; Peptidyl-Dipeptidase A; Pregnancy; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetrazoles; Valine; Valsartan; Vasoconstrictor Agents | 2006 |
High glucose and angiotensin II increase beta1 integrin and integrin-linked kinase synthesis in cultured mouse podocytes.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Adhesion; Cell Line, Transformed; Dose-Response Relationship, Drug; Drug Combinations; Gene Expression; Glucose; Integrin beta1; Losartan; Mice; Microscopy, Fluorescence; Podocytes; Protein Serine-Threonine Kinases; RNA, Messenger | 2006 |
Interaction between arginine vasopressin and angiotensin II receptors in the central regulation of sodium balance.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Arginine Vasopressin; Blood Pressure; Dose-Response Relationship, Drug; Hypothalamus; Injections, Intraventricular; Losartan; Male; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Receptors, Vasopressin; Sodium | 2005 |
Apoptosis of circulating lymphocyte in rats with unilateral ureteral obstruction: role of angiotensin II.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Apoptosis; Enalapril; Leukocyte Count; Losartan; Lymphocytes; Male; Rats; Rats, Wistar; Ureteral Obstruction | 2005 |
Effects of renin-angiotensin system blockade on renal angiotensin-(1-7) forming enzymes and receptors.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Carboxypeptidases; Gene Expression Regulation, Enzymologic; Hypertension, Renal; Kidney; Lisinopril; Losartan; Male; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Rats, Inbred Lew; Receptors, Angiotensin; Renin-Angiotensin System | 2005 |
Angiotensin II inhibition attenuates postexercise proteinuria in rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Enalapril; Kallikrein-Kinin System; Losartan; Male; Physical Conditioning, Animal; Proteinuria; Rats; Rats, Wistar | 2005 |
Losartan reduces monocyte chemoattractant protein-1 expression in aortic tissues of 2K1C hypertensive rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Chemokine CCL2; Enzyme-Linked Immunosorbent Assay; Hypertension, Renovascular; In Situ Hybridization; Losartan; Male; Radioimmunoassay; Rats; Rats, Inbred WKY; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 2006 |
Angiotensin II activates matrix metalloproteinase type II and mimics age-associated carotid arterial remodeling in young rats.
Topics: Adrenergic alpha-Agonists; Aging; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Blotting, Western; Carotid Arteries; Collagen; Dipeptides; Immunohistochemistry; Losartan; Male; Matrix Metalloproteinase 2; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Organ Culture Techniques; Phenylephrine; Protease Inhibitors; Rats; RNA, Messenger; Transcription, Genetic; Transforming Growth Factor beta; Tunica Intima; Vasoconstrictor Agents | 2005 |
Angiotensin II and angiotensin II receptor blocker modulate the arrhythmogenic activity of pulmonary veins.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Anti-Arrhythmia Agents; Electrophysiology; Losartan; Pulmonary Veins; Rabbits | 2006 |
Simvastatin and losartan enhance nitric oxide and reduce oxidative stress in salt-induced hypertension.
Topics: Acetylcholine; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Pressure; Body Weight; Drug Therapy, Combination; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; In Vitro Techniques; Kidney; Losartan; Male; Mesenteric Arteries; Myocardium; Nitric Oxide; Organ Size; Oxidative Stress; Prostaglandins; Rats; Rats, Inbred Dahl; Simvastatin; Sodium Chloride, Dietary; Superoxides; Thromboxane A2; Treatment Outcome; Vasoconstriction; Vasodilator Agents | 2005 |
Signaling pathways in the biphasic effect of ANG II on Na+/H+ exchanger in T84 cells.
Topics: Amiloride; Angiotensin II; Calcium; Cell Line, Tumor; Cell Size; Colon; Colonic Neoplasms; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Hydrogen-Ion Concentration; Isoquinolines; Losartan; Signal Transduction; Sodium-Hydrogen Exchangers; Staurosporine; Sulfonamides | 2005 |
NAD(P)H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Anthracenes; Aorta, Thoracic; Cell Differentiation; Cells, Cultured; Connective Tissue; Fibroblasts; Free Radical Scavengers; Imidazoles; JNK Mitogen-Activated Protein Kinases; Losartan; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Oligodeoxyribonucleotides, Antisense; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2006 |
Novel polymer monolith microextraction using a poly(methacrylic acid-ethylene glycol dimethacrylate) monolith and its application to simultaneous analysis of several angiotensin II receptor antagonists in human urine by capillary zone electrophoresis.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Benzimidazoles; Benzoates; Biphenyl Compounds; Electrophoresis, Capillary; Ethylene Glycols; Humans; Irbesartan; Losartan; Methacrylates; Receptors, Angiotensin; Sensitivity and Specificity; Telmisartan; Tetrazoles | 2006 |
Angiotensin II-dependent vascular alterations in young cardiomyopathic hamsters: role for oxidative stress.
Topics: Acetylcysteine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Aorta; Blood Pressure; Cardiomyopathies; Cricetinae; Disease Models, Animal; Losartan; Male; Mesocricetus; NADPH Oxidases; Oxidative Stress; Superoxides | 2006 |
Effects of intracerebroventricular losartan on angiotensin II-mediated pressor responses and c-fos expression in near-term ovine fetus.
Topics: Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Female; Fetus; Genes, fos; Gestational Age; Homeostasis; Injections, Intraventricular; Losartan; Pregnancy; Prosencephalon; Sheep; Statistics, Nonparametric | 2005 |
Effect of losartan pretreatment on kidney lipid content after unilateral obstruction in rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cholesterol; Fatty Acids; Female; Gene Expression Regulation; Kidney Cortex; Lipid Metabolism; Lipids; Losartan; Phosphatidylcholines; Phosphatidylethanolamines; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; RNA, Messenger; Sphingomyelins; Ureteral Obstruction | 2005 |
Angiotensin-mediated increase in renal sympathetic nerve discharge within the PVN: role of nitric oxide.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensins; Animals; Blood Pressure; Feedback, Physiological; Heart Rate; Losartan; Male; Microinjections; Nitric Oxide; Nitric Oxide Synthase Type I; omega-N-Methylarginine; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System | 2006 |
Role of angiotensin type-1 and angiotensin type-2 receptors in the expression of vascular integrins in angiotensin II-infused rats.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Vessels; Hydralazine; Hypertension; Infusion Pumps; Integrins; Losartan; Male; Osteopontin; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sialoglycoproteins; Vasoconstrictor Agents; Vasodilator Agents | 2006 |
Significance of angiotensin II receptor blocker lipophilicities and their protective effect against vascular remodeling.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Blood Pressure; Body Weight; Carotid Artery Diseases; Gene Expression; Hypertension; Immunohistochemistry; Lipids; Losartan; Male; Membrane Transport Proteins; Myocardium; NADPH Oxidases; Nitric Oxide Synthase Type III; Organ Size; Phosphoproteins; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin; Telmisartan; Vasodilation | 2005 |
Angiotensin II via AT1 receptor accelerates arterial thrombosis in renovascular hypertensive rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Carotid Artery Thrombosis; Carotid Artery, Common; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Fibrinolysis; Hemostasis; Hypertension, Renovascular; Infusions, Intravenous; Losartan; Male; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Time Factors; Vasoconstrictor Agents | 2005 |
Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect.
Topics: Alkaloids; Amiloride; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzophenanthridines; Diastole; Dose-Response Relationship, Drug; Elasticity; Heart; Losartan; Male; Myocardial Contraction; Myocardium; Naphthyridines; Phenanthridines; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Receptor, Angiotensin, Type 1; Sodium-Hydrogen Exchangers; Ventricular Function, Left | 2006 |
Renal vascular responses in an experimental model of preeclampsia.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aortic Coarctation; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Losartan; Pre-Eclampsia; Pregnancy; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renal Circulation | 2005 |
Differential effects of prenatal exposure to dexamethasone or cortisol on circulatory control mechanisms mediated by angiotensin II in the central nervous system of adult sheep.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Blood Pressure; Cardiac Output; Dexamethasone; Female; Gestational Age; Heart Rate; Hydrocortisone; Injections, Intraventricular; Losartan; Male; Pregnancy; Prenatal Exposure Delayed Effects; Renin-Angiotensin System; Sheep; Time Factors; Vasoconstrictor Agents | 2006 |
Remodeling and angiotensin II responses of the uterine arcuate arteries of pregnant rats are altered by low- and high-sodium intake.
Topics: Aldosterone; Angiotensin II; Animals; Arteries; Dose-Response Relationship, Drug; Female; Losartan; Muscle Contraction; Muscle, Smooth, Vascular; Myography; Pregnancy; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System; Sodium Chloride; Sodium, Dietary; Uterus | 2006 |
AT1 receptor-mediated accumulation of extracellular angiotensin II in proximal tubule cells: role of cytoskeleton microtubules and tyrosine phosphatases.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arsenicals; Cells, Cultured; Colchicine; Colforsin; Cyclic AMP; Cytoskeleton; Endocytosis; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Kidney Tubules, Proximal; Losartan; Microtubules; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Pyridines; Rabbits; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Signal Transduction; Sucrose | 2006 |
Pressor responses to alligator Angiotensin I and some analogs in the spectacled caiman (Caiman crocodilus).
Topics: Alligators and Crocodiles; Angiotensin I; Angiotensin II; Angiotensin III; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Dose-Response Relationship, Drug; Epinephrine; Losartan; Male; Norepinephrine | 2006 |
Increased vascular angiotensin II binding capacity and ET-1 release in young cardiomyopathic hamsters.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Binding, Competitive; Cardiomyopathies; Cricetinae; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin-1; In Vitro Techniques; Losartan; Male; Mesocricetus; Peptides, Cyclic; Protein Binding; Receptor, Angiotensin, Type 1; Receptor, Endothelin A; Vasoconstriction; Vasoconstrictor Agents | 2006 |
Glycogen synthase kinase 3beta together with 14-3-3 protein regulates diabetic cardiomyopathy: effect of losartan and tempol.
Topics: 14-3-3 Proteins; Angiotensin II; Animals; Apoptosis; Blood Glucose; Body Weight; Cardiomegaly; Cardiomyopathies; Cyclic N-Oxides; Diabetes Complications; Endomyocardial Fibrosis; Glycogen Synthase Kinase 3; Losartan; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Myocardium; NFATC Transcription Factors; Organ Size; Oxidative Stress; Phosphorylation; Protein Transport; Signal Transduction; Spin Labels; Streptozocin | 2006 |
Transactivation of the epidermal growth factor receptor by angiotensin II in glomerular podocytes.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Cell Line; Coculture Techniques; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Green Fluorescent Proteins; Heparin-binding EGF-like Growth Factor; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Kidney Glomerulus; Losartan; Metalloproteases; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Phosphorylation; Podocytes; Protease Inhibitors; Pyridines; Recombinant Fusion Proteins; Time Factors; Transcriptional Activation | 2006 |
Direct positive chronotropic action by angiotensin II in the isolated mouse atrium.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Dose-Response Relationship, Drug; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Isoproterenol; Losartan; Male; Mice; Mice, Inbred C57BL; Nadolol; Stimulation, Chemical; Vasoconstrictor Agents | 2006 |
Angiotensin-converting enzyme and angiotensin II receptor subtype 1 inhibitors restitute hypertensive internal anal sphincter in the spontaneously hypertensive rats.
Topics: Anal Canal; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Blotting, Western; Captopril; Hypertension; Losartan; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rectum; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; RNA | 2006 |
Increased renal vascular reactivity to ANG II after unilateral nephrectomy in the rat involves 20-HETE.
Topics: Adaptation, Physiological; Amidines; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Dinoprostone; Hydroxyeicosatetraenoic Acids; Imidazoles; Indomethacin; Losartan; Male; Microcirculation; Nephrectomy; Norepinephrine; Pyridines; Rats; Rats, Wistar; Renal Circulation; Vasoconstriction; Vasoconstrictor Agents | 2006 |
Effects of i.c.v. losartan on the angiotensin II-mediated vasopressin release and hypothalamic fos expression in near-term ovine fetuses.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Female; Fetus; Hypothalamus; Imidazoles; Injections, Intraventricular; Losartan; Pregnancy; Proto-Oncogene Proteins c-fos; Pyridines; Sheep; Time Factors; Vasopressins | 2006 |
The contribution of brain angiotensin II to the baroreflex regulation of renal sympathetic nerve activity in conscious normotensive and hypertensive rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Baroreflex; Blood Pressure; Brain Chemistry; Hypertension; Kidney; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, Angiotensin; Sodium, Dietary; Sympathetic Nervous System | 2006 |
Angiotensin II disrupts inhibitory avoidance memory retrieval.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Anxiety; Avoidance Learning; Dose-Response Relationship, Drug; Exploratory Behavior; Imidazoles; Losartan; Male; Memory; Motor Activity; Pyridines; Rats; Rats, Wistar | 2006 |
Abnormal renovascular parathyroid hormone-1 receptor in hypertension: Primary defect or secondary to angiotensin ii type 1 receptor activation?
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arteries; Cells, Cultured; Desoxycorticosterone; Down-Regulation; Hypertension; Kidney; Losartan; Male; Parathyroid Hormone-Related Protein; Rats; Rats, Inbred SHR; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Parathyroid Hormone, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vasodilation | 2006 |
Effect of angiotensin II blockade on a new congenic model of hypertension derived from transgenic Ren-2 rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Congenic; Animals, Genetically Modified; Crosses, Genetic; Hypertension, Renal; Kinetics; Lisinopril; Losartan; Male; Models, Genetic; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Rats, Inbred Lew; Renin; Renin-Angiotensin System; RNA, Messenger; Time Factors | 2006 |
Biphasic actions of angiotensin IV on renal blood flow in the rat.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Dose-Response Relationship, Drug; Imidazoles; Indomethacin; Kidney; Losartan; Male; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Regional Blood Flow; Vasodilator Agents | 2006 |
The parathyroid hormone-related protein system and diabetic nephropathy outcome in streptozotocin-induced diabetes.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Blotting, Western; Cell Line; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Epithelial Cells; Gene Expression Regulation; Hypertrophy; Immunohistochemistry; Kidney Tubules; Losartan; Mesangial Cells; Mice; Mice, Transgenic; Parathyroid Hormone-Related Protein; Podocytes; Receptor, Parathyroid Hormone, Type 1 | 2006 |
Role of angiotensin II in retinal leukostasis in the diabetic rat.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Concanavalin A; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Intercellular Adhesion Molecule-1; Leukocyte Common Antigens; Leukostasis; Losartan; Male; Nifedipine; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Ramipril; Rats; Rats, Long-Evans; Retina; Retinal Diseases | 2006 |
Modulation of kinin B1 receptor expression by endogenous angiotensin II in hypertensive rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Gene Expression Regulation; Hypertension; Kidney; Kinins; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2006 |
Endothelin ETA receptors and endothelium partially mediate the positive inotropic and lusitropic effects of angiotensin II.
Topics: Angiotensin II; Animals; Dose-Response Relationship, Drug; Endothelium; Losartan; Muscle Contraction; Muscles; Myocardial Contraction; Myocardium; Oligopeptides; Rabbits; Receptor, Endothelin A; Receptors, Endothelin | 2006 |
Effects of angiotensin II on connexin 43 of VSMCs in arteriosclerosis.
Topics: Angiotensin II; Animals; Arteriosclerosis; Body Weight; Cholesterol; Connexin 43; Losartan; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rabbits; Ramipril; RNA, Messenger | 2006 |
[Effect of angiotensin II and its receptor antagonist on electrophysiology and L-type calcium current in guinea cardiac myocytes].
Topics: Action Potentials; Angiotensin II; Animals; Calcium Channels, L-Type; Cells, Cultured; Female; Guinea Pigs; Losartan; Male; Myocytes, Cardiac; Patch-Clamp Techniques | 2006 |
AT1 antagonist modulates activin-like kinase 5 and TGF-beta receptor II in the developing kidney.
Topics: Actins; Activin Receptors, Type I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Enzyme Inhibitors; Female; Gene Expression Regulation, Developmental; Kidney; Losartan; Pregnancy; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; RNA, Messenger; Transforming Growth Factor beta1 | 2006 |
Cardiac sympathetic afferent stimulation augments the arterial chemoreceptor reflex in anesthetized rats.
Topics: Analgesics, Non-Narcotic; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arteries; Blood Pressure; Capsaicin; Cardiovascular Physiological Phenomena; Cardiovascular System; Chemoreceptor Cells; Electric Stimulation; Losartan; Male; Neurons, Afferent; Nicotine; Potassium Cyanide; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Solitary Nucleus; Sympathetic Nervous System; Unconsciousness | 2007 |
Angiotensin II induced contraction of rat and human small intestinal wall musculature in vitro.
Topics: Adrenergic Antagonists; Adult; Aged; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Atropine; Blotting, Western; Cholinergic Antagonists; Dose-Response Relationship, Drug; Female; Guanethidine; Humans; Imidazoles; In Vitro Techniques; Intestine, Small; Losartan; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Pyridines; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Species Specificity | 2006 |
Angiotensin II activates intermediate-conductance Ca2+ -activated K+ channels in arterial smooth muscle cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cells, Cultured; Diglycerides; Enzyme Inhibitors; Intermediate-Conductance Calcium-Activated Potassium Channels; Losartan; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Protein Kinase C; Rats; Receptor, Angiotensin, Type 1; Signal Transduction | 2006 |
Angiotensin II increases expression and secretion of cathepsin F in cultured human monocyte-derived macrophages: an angiotensin II type 2 receptor-mediated effect.
Topics: Angiotensin II; Atherosclerosis; Cathepsin F; Cathepsins; Cell Survival; Humans; Imidazoles; Losartan; Macrophages; Pyridines; Receptor, Angiotensin, Type 2 | 2007 |
Translocation of AT1- and AT2-receptors by higher concentrations of angiotensin II in the smooth muscle cells of rat internal anal sphincter.
Topics: Anal Canal; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biotin; Blotting, Western; Cytosol; Fluorescent Antibody Technique; Imidazoles; In Vitro Techniques; Losartan; Male; Microscopy, Confocal; Muscle, Smooth; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Reverse Transcriptase Polymerase Chain Reaction; Translocation, Genetic | 2006 |
Angiotensin II regulates extraneuronal dopamine uptake in the kidney.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Dopamine; Dose-Response Relationship, Drug; Hydrocortisone; Imidazoles; In Vitro Techniques; Kidney; Kidney Tubules, Proximal; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sodium; Temperature; Time Factors | 2006 |
The role of angiotensin II in stress urinary incontinence: A rat model.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Blood Pressure; Disease Models, Animal; Female; Imidazoles; Losartan; Peripheral Nerve Injuries; Pressure; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Urethra; Urinary Bladder; Urinary Incontinence, Stress; Vasoconstrictor Agents | 2007 |
Angiotensins II and IV modulate adrenocortical cell proliferation in ovariectomized rats.
Topics: Adrenal Cortex; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Bromodeoxyuridine; Cell Proliferation; Female; Histocytochemistry; Losartan; Models, Animal; Ovariectomy; Rats; Rats, Wistar | 2006 |
Expression and localization of PDGF-B, PDGF-D, and PDGF receptor in the kidney of angiotensin II-infused rat.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Apoptosis; Cell Proliferation; Gene Expression Regulation; Hydralazine; In Situ Hybridization; Iron; Kidney; Lipid Metabolism; Losartan; Lymphokines; Male; Norepinephrine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor beta; RNA, Messenger; Vasoconstrictor Agents | 2006 |
Ang II and Ang III modulate PTZ seizure threshold in non-stressed and stressed mice: possible involvement of noradrenergic mechanism.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin III; Animals; Convulsants; Desipramine; Imidazoles; Injections, Intraperitoneal; Injections, Intraventricular; Losartan; Male; Mice; Mice, Inbred ICR; Norepinephrine; Pentylenetetrazole; Pyridines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Restraint, Physical; Seizures; Stress, Psychological; Sympathetic Nervous System | 2006 |
Centrally injected angiotensin II trans-synaptically activates angiotensin II-sensitive neurons in the anterior hypothalamic area of rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Calmodulin; Carbachol; Electric Stimulation; Hypothalamus, Anterior; Injections, Intraventricular; Losartan; Male; Muscarinic Agonists; Neurons; Rats; Rats, Wistar; Sulfonamides | 2006 |
Blockade of the renin-angiotensin system improves insulin sensitivity in thermal injury.
Topics: Angiotensin II; Animals; Area Under Curve; Blood Glucose; Burns; Insulin; Insulin Resistance; Losartan; Male; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System | 2006 |
Angiotensin II-induced C-reactive protein generation: inflammatory role of vascular smooth muscle cells in atherosclerosis.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Atherosclerosis; C-Reactive Protein; Cells, Cultured; Losartan; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats; Receptor Cross-Talk | 2007 |
Activation of endothelin-a receptors contributes to angiotensin-induced suppression of renal sensory nerve activation.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Dinoprostone; Dose-Response Relationship, Drug; Drug Combinations; Endothelin A Receptor Antagonists; Kidney; Kidney Pelvis; Losartan; Male; Mechanoreceptors; Neurons, Afferent; Peptides, Cyclic; Pressure; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sodium, Dietary; Substance P | 2007 |
Systemic inhibition of the angiotensin-converting enzyme limits lipopolysaccharide-induced lung neutrophil recruitment through both bradykinin and angiotensin II-regulated pathways.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Cell Migration Inhibition; Chemokine CXCL1; Chemokine CXCL2; Chemokines; Chemokines, CXC; Chemotaxis, Leukocyte; Down-Regulation; Female; Lipopolysaccharides; Losartan; Lung; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; Plasminogen Activator Inhibitor 1; Receptors, Bradykinin; Signal Transduction | 2006 |
ACE inhibitors and aortic rupture.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Aortic Aneurysm; Atherosclerosis; Humans; Losartan; Mice | 2006 |
Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor.
Topics: Adenoviridae; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Cardiovascular System; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Fibroblasts; Genetic Vectors; Hypertension; Imidazoles; Losartan; Male; Myocardium; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Time Factors; Transduction, Genetic; Up-Regulation | 2007 |
Angiotensin II-induced MAPK phosphorylation mediated by Ras and/or phospholipase C-dependent phosphorylations but not by protein kinase C phosphorylation in cultured rat vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Farnesol; Indoles; Losartan; Male; Maleimides; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphorylation; Protein Kinase C; Pyrrolidinones; ras Proteins; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Salicylates; Time Factors; Type C Phospholipases | 2007 |
Enhanced AT1 receptor-mediated vasocontractile response to ANG II in endothelium-denuded aorta of obese Zucker rats.
Topics: Acetylcholine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Body Weight; Endothelial Cells; Endothelin-1; Enzyme Inhibitors; In Vitro Techniques; Losartan; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Nitroprusside; Obesity; Potassium Chloride; Rats; Rats, Zucker; Receptor, Angiotensin, Type 1; RNA, Messenger; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2007 |
AT1 receptor blockade prevents microvascular dysfunction induced by ischemia/reperfusion injury.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Bradykinin; Capillary Permeability; Cell Adhesion; Leukocyte Rolling; Leukocytes; Losartan; Male; Mesentery; Models, Animal; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Venules; Videotape Recording | 2006 |
[Alteration of signal transduction-associated gene expression in rat cardiac fibroblasts induced by blocking angiotensin II receptors].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Fibroblasts; Gene Expression; Imidazoles; Losartan; Myocardium; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Signal Transduction | 2006 |
The role of angiotensin receptor-1 blockade on electromechanical changes induced by left ventricular hypertrophy and its regression.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Constriction; Electrocardiography; Guinea Pigs; Heart; Hypertrophy, Left Ventricular; Losartan; Male; Models, Animal; Time Factors | 2007 |
Prevention of interstitial fibrosis of renal allograft by angiotensin II blockade.
Topics: Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Cyclosporine; Female; Fibrosis; Humans; Immunosuppressive Agents; Kidney Transplantation; Losartan; Male; Middle Aged; Postoperative Complications | 2006 |
Angiotensin II increases adipose angiotensinogen expression.
Topics: Adipose Tissue; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Blotting, Western; Gene Expression Regulation; Liver; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, LDL; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2007 |
Angiotensin II induces endothelial xanthine oxidase activation: role for endothelial dysfunction in patients with coronary disease.
Topics: Aged; Allopurinol; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cattle; Cells, Cultured; Coronary Circulation; Coronary Disease; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Losartan; Male; Middle Aged; NADPH Oxidases; Oxypurinol; Superoxides; Vasodilation; Xanthine Oxidase | 2007 |
Investigation of the mechanisms by which chronic infusion of an acutely subpressor dose of angiotensin II induces hypertension.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hypertension; Losartan; Receptor, Angiotensin, Type 1; Sheep | 2007 |
[Effects of losartan on the levels of angiotensin II and its type-1 receptor in diabetic rat kidney].
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Diabetes Mellitus, Experimental; Immunoassay; Kidney; Losartan; Male; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2006 |
Intracerebroventricular injection of losartan inhibits angiotensin II-sensitive neurons via GABA inputs in the anterior hypothalamic area of rats.
Topics: Action Potentials; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Anterior Hypothalamic Nucleus; Bicuculline; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Intraventricular; Losartan; Male; Microelectrodes; Neurons; Rats; Rats, Wistar | 2007 |
Induction of monocyte chemoattractant protein-1 expression by angiotensin II in the pancreatic islets and beta-cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Line, Tumor; Chemokine CCL2; Diabetes Mellitus, Type 1; Gene Expression; Hyperglycemia; Imidazoles; Insulin-Secreting Cells; Insulinoma; Interleukin-1beta; Losartan; Mice; Mice, Inbred NOD; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Pancreatic Neoplasms; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Pyridines; Rats; Receptor, Angiotensin, Type 1; RNA, Messenger; Vasoconstrictor Agents | 2007 |
Identification of a novel non-AT1, non-AT2 angiotensin binding site in the rat brain.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Autoradiography; Binding, Competitive; Brain; Drug Interactions; Imidazoles; Iodine Isotopes; Losartan; p-Chloromercuribenzoic Acid; Pyridines; Rats; Rats, Sprague-Dawley | 2007 |
Angiotensin-(3-7) pressor effect at the rostral ventrolateral medulla.
Topics: Anesthetics, Intravenous; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Losartan; Male; Medulla Oblongata; Microinjections; Peptide Fragments; Pulsatile Flow; Rats; Rats, Wistar; Urethane | 2007 |
Central AT(1) receptor blockade increases metabolic cost during exercise reducing mechanical efficiency and running performance in rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biomechanical Phenomena; Body Temperature Regulation; Calorimetry, Indirect; Energy Metabolism; Injections, Intraventricular; Losartan; Male; Muscle Fatigue; Oxygen Consumption; Physical Exertion; Rats; Rats, Wistar; Running | 2007 |
Local production of angiotensin II in the subfornical organ causes elevated drinking.
Topics: Angiotensin II; Animals; Cerebral Ventricles; Drinking Behavior; Electrolytes; Homeostasis; Humans; Injections, Intraventricular; Losartan; Mice; Mice, Transgenic; Neurons; Promoter Regions, Genetic; Renin; Subfornical Organ | 2007 |
Angiotensin II-induced sudden arrhythmic death and electrical remodeling.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Animals, Genetically Modified; Blood Pressure; Cardiac Pacing, Artificial; Cardiomegaly; Connexin 43; Death, Sudden, Cardiac; Disease Models, Animal; Electrocardiography; Heart Conduction System; Hypertension; Losartan; Male; Myocardium; Rats; Rats, Sprague-Dawley; Renin; RNA, Messenger; Shal Potassium Channels; Tachycardia, Ventricular; Telemetry; Time Factors; Ventricular Remodeling | 2007 |
Selective knockdown of AT1 receptors by RNA interference inhibits Val5-ANG II endocytosis and NHE-3 expression in immortalized rabbit proximal tubule cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Line; Colchicine; Cold Temperature; Down-Regulation; Endocytosis; Kidney Tubules, Proximal; Losartan; Microtubules; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Rabbits; Receptor, Angiotensin, Type 1; RNA Interference; RNA, Small Interfering; Sodium; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Time Factors; Transfection; Tubulin Modulators | 2007 |
Modulation of angiotensin II and norepinephrine-induced plasminogen activator inhibitor-1 expression by AT1a receptor deficiency.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Pressure; Gene Expression Regulation; Kidney; Liver; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Norepinephrine; Plasminogen Activator Inhibitor 1; Random Allocation; Receptor, Angiotensin, Type 1; RNA, Messenger; Vasoconstrictor Agents | 2007 |
Angiotensin II promotes the inflammatory response to CD40 ligation via TRAF-2.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Atherosclerosis; CD40 Antigens; CD40 Ligand; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Inflammation; Interleukin-6; Losartan; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Receptor Cross-Talk; Receptor, Angiotensin, Type 1; Saphenous Vein; TNF Receptor-Associated Factor 2; Up-Regulation | 2007 |
Angiotensin II increases expression of alpha1C subunit of L-type calcium channel through a reactive oxygen species and cAMP response element-binding protein-dependent pathway in HL-1 myocytes.
Topics: Angiotensin II; Animals; Calcium; Calcium Channels, L-Type; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; DNA; Losartan; Myocytes, Cardiac; NADPH Oxidases; Protein Kinase C; Rats; Rats, Wistar; Reactive Oxygen Species; Response Elements; Simvastatin; Superoxides; Transcription, Genetic | 2007 |
Early left ventricular gene expression profile in response to increase in blood pressure.
Topics: Acute Disease; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Arginine Vasopressin; bcl-X Protein; Blood Pressure; Cell Cycle Proteins; Chronic Disease; Consciousness; DNA, Complementary; Early Growth Response Protein 1; Eye Proteins; Fatty Acid-Binding Proteins; Gene Expression Profiling; Gene Expression Regulation; Heart Ventricles; HSP70 Heat-Shock Proteins; Hypertension; Losartan; Male; Nerve Growth Factor; Nerve Tissue Proteins; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Plasminogen Activator Inhibitor 1; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2006 |
Modulation of a delayed-rectifier K+ current by angiotensin II in rat sympathetic neurons.
Topics: Adenosine Triphosphate; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cells, Cultured; Delayed Rectifier Potassium Channels; Electric Stimulation; Guanosine Diphosphate; Guanosine Triphosphate; Losartan; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Rats, Wistar; Superior Cervical Ganglion; Tetradecanoylphorbol Acetate; Thionucleotides; Vasoconstrictor Agents | 2007 |
Angiotensin-(1 7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: role of the AT1 and Mas receptors.
Topics: Androstadienes; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Dose-Response Relationship, Drug; Insulin; Insulin Receptor Substrate Proteins; Janus Kinase 2; Losartan; Male; Myocardium; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Signal Transduction; Tyrphostins; Wortmannin | 2007 |
17beta-estradiol inhibits angiotensin II-induced collagen synthesis of cultured rat cardiac fibroblasts via modulating angiotensin II receptors.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blotting, Western; Cell Proliferation; Cells, Cultured; Collagen; Estradiol; Estrogen Antagonists; Fibroblasts; Fulvestrant; Heart; Imidazoles; Indicators and Reagents; Losartan; Myocardium; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2007 |
Angiotensin II protects fibroblast-like synoviocytes from apoptosis via the AT1-NF-kappaB pathway.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Apoptosis; Arthritis, Rheumatoid; Caspase 3; Cells, Cultured; Enzyme Activation; Fibroblasts; Humans; Losartan; NF-kappa B; Osteoarthritis, Hip; Receptor, Angiotensin, Type 1; Signal Transduction; Synovial Membrane | 2007 |
Genetic deletion of AT1a receptors attenuates intracellular accumulation of ANG II in the kidney of AT1a receptor-deficient mice.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Autoradiography; Blood Pressure; Drinking; Endocytosis; Kidney; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Potassium; Receptor, Angiotensin, Type 1; Sodium | 2007 |
Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production.
Topics: Acetophenones; Allopurinol; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Drug Antagonism; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Indomethacin; Losartan; Male; NADH, NADPH Oxidoreductases; NG-Nitroarginine Methyl Ester; Onium Compounds; Peptide Fragments; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Superoxides | 2007 |
Role of asymmetric dimethylarginine in inflammatory reactions by angiotensin II.
Topics: Amidohydrolases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Arginine; Cell Adhesion; Cells, Cultured; Culture Media, Conditioned; Endothelial Cells; Endothelium, Vascular; Gene Expression Regulation; Humans; Interleukin-8; Losartan; Monocytes; NF-kappa B; Nitrates; Nitric Oxide; Nitrites; Protein-Arginine N-Methyltransferases; Reactive Oxygen Species; Receptors, Interleukin-8B; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha; Umbilical Veins; Vasculitis; Vasodilation | 2007 |
Protective effect of long-term angiotensin II inhibition.
Topics: Aging; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Blood Pressure; Body Weight; Cardiovascular System; Enalapril; Losartan; Male; Myocardium; Oxidative Stress; Random Allocation; Rats; Rats, Wistar; Renin-Angiotensin System | 2007 |
[Effect of losartan on portal hypertensive gastropathy in rats].
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Gastric Mucosa; Hypertension, Portal; Losartan; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; RNA, Messenger; Stomach Diseases | 2007 |
Angiotensin inhibition decreases progression of advanced atherosclerosis and stabilizes established atherosclerotic plaques.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Blood Pressure; Body Weight; Disease Progression; Elasticity; Female; Hydralazine; Lipids; Losartan; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Vasoconstrictor Agents | 2007 |
Intravenous hypertonic NaCl acts via cerebral sodium-sensitive and angiotensinergic mechanisms to improve cardiac function in haemorrhaged conscious sheep.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cardiovascular System; Consciousness; Diuretics, Osmotic; Female; Hemorrhage; Hypovolemia; Infusions, Intravenous; Injections, Intraventricular; Losartan; Mannitol; Osmolar Concentration; Receptor, Angiotensin, Type 1; Resuscitation; Saline Solution, Hypertonic; Sheep; Sodium; Vascular Resistance; Vasopressins | 2007 |
Angiotensin II attenuates myocardial interstitial acetylcholine release in response to vagal stimulation.
Topics: Acetylcholine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cats; Electric Stimulation; Ganglia, Parasympathetic; Heart; Heart Ventricles; Infusions, Intravenous; Losartan; Microdialysis; Myocardium; Receptor, Angiotensin, Type 1; Vagus Nerve | 2007 |
[Losartan inhibited angiotensin induced human lung fibroblast transformation and collagen synthesis].
Topics: Angiotensin II; Cell Differentiation; Cells, Cultured; Collagen; Fibroblasts; Humans; Losartan; Pulmonary Fibrosis | 2007 |
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis.
Topics: Acetophenones; Acetylcysteine; Angiogenesis Inhibitors; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Imidazoles; Indoles; Leukostasis; Losartan; Male; NADPH Oxidases; Pyridines; Pyrroles; Rats; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Retinal Diseases; Vascular Endothelial Growth Factor A; Vasoconstrictor Agents | 2007 |
The effect of diet on simvastatin and losartan enhancement of endothelial function.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Diet; Diet, Sodium-Restricted; Dietary Fats; Endothelium, Vascular; Epoprostenol; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Kidney; Lipids; Losartan; Male; Nitric Oxide; Rats; Rats, Inbred SHR; Simvastatin; Sodium, Dietary; Superoxides; Thromboxane A2 | 2007 |
[Peroxisome proliferator-activated receptor activator troglitazone inhibits angiotensin II-stimulated secretion of vasoactive factors by endothelial cells].
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Cell Line; Chromans; Dose-Response Relationship, Drug; Endothelial Cells; Endothelin-1; Gene Expression Regulation; Humans; Hypertension; Immunohistochemistry; Losartan; Nitric Oxide; PPAR gamma; Receptor, Angiotensin, Type 1; Thiazolidinediones; Troglitazone | 2007 |
Angiotensin II AT1 receptor blockade normalizes CD11b+ monocyte production in bone marrow of hypercholesterolemic monkeys.
Topics: Angiotensin II; Animals; Antigens, CD34; Bone Marrow Cells; CD11b Antigen; Cholesterol; Cholesterol, Dietary; Hypercholesterolemia; Leukocytes, Mononuclear; Losartan; Macaca fascicularis; Male; Receptor, Angiotensin, Type 1; Renin-Angiotensin System | 2008 |
Angiotensin AT1 receptor blockers suppress ischemia/reperfusion-induced gastric injury in rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Capillary Permeability; Gastric Mucosa; Hydrogen Peroxide; Losartan; Male; Microcirculation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tetrazoles; Valine; Valsartan | 2007 |
Involvement of an enterocyte renin-angiotensin system in the local control of SGLT1-dependent glucose uptake across the rat small intestinal brush border membrane.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Autocrine Communication; Blotting, Western; Enterocytes; Glucose; Ileum; Immunohistochemistry; In Vitro Techniques; Jejunum; Leucine; Losartan; Male; Microvilli; Peptidyl-Dipeptidase A; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; RNA, Messenger; Sodium-Glucose Transporter 1 | 2007 |
Cross-talk related to insulin and angiotensin II binding on myocardial remodelling in diabetic rat hearts.
Topics: Angiotensin II; Animals; Anti-Arrhythmia Agents; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Heart; Insulin; Losartan; Myocardial Infarction; Organ Size; Rats; Receptor Cross-Talk; Receptor, Insulin; Receptors, Angiotensin; Reference Values | 2007 |
Angiotensin II is a critical mediator of prazosin-induced angiogenesis in skeletal muscle.
Topics: Angiotensin II; Animals; Losartan; Muscle, Skeletal; Neovascularization, Physiologic; Prazosin; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Sodium Chloride; Vascular Endothelial Growth Factor A; Vasodilator Agents | 2007 |
CXCR2 blockade impairs angiotensin II-induced CC chemokine synthesis and mononuclear leukocyte infiltration.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Atherosclerosis; Cell Adhesion; Cells, Cultured; Chemokine CCL2; Chemokine CCL3; Chemokine CCL4; Chemokine CCL5; Chemokine CCL7; Chemotaxis, Leukocyte; Endothelial Cells; Humans; Inflammation; Leukocytes, Mononuclear; Losartan; Macrophage Inflammatory Proteins; Male; Microcirculation; Monocyte Chemoattractant Proteins; Neutrophil Infiltration; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-8B; Splanchnic Circulation | 2007 |
Reactive oxygen species in the paraventricular nucleus mediate the cardiac sympathetic afferent reflex in chronic heart failure rats.
Topics: Afferent Pathways; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Heart; Heart Failure; Losartan; Male; Models, Animal; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Superoxides; Sympathetic Nervous System; Vasoconstrictor Agents | 2007 |
Angiotension II receptor 1 blocker modifies the expression of apoptosis-related proteins and transforming growth factor-beta1 in prostate tissue of spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; bcl-2-Associated X Protein; Blotting, Western; Losartan; Male; Prostate; Prostatic Hyperplasia; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Transforming Growth Factor beta1 | 2007 |
The renin-angiotensin and "drinking" behavior.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Drinking Behavior; Humans; Losartan; Mice; Rabbits; Renin; Renin-Angiotensin System; Thirst | 2007 |
Angiotensin II receptors subtypes mediate diverse gene expression profile in adult hypertrophic cardiomyocytes.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Aorta, Abdominal; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Imidazoles; Interleukin-1beta; Interleukin-6; Ligation; Losartan; Male; Myocytes, Cardiac; Oligonucleotide Array Sequence Analysis; Pyridines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha | 2007 |
Angiotensin II protects against alpha-synuclein toxicity and reduces protein aggregation in vitro.
Topics: alpha-Synuclein; Angiotensin II; Cell Line, Tumor; Electrophoresis, Polyacrylamide Gel; Humans; Imidazoles; Immunoblotting; Inclusion Bodies; Losartan; Parkinson Disease; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Vasoconstrictor Agents | 2007 |
Anabolic steroids induce cardiac renin-angiotensin system and impair the beneficial effects of aerobic training in rats.
Topics: Anabolic Agents; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cardiomegaly; Collagen; Gene Expression Regulation; Heart Rate; Hydroxyproline; Losartan; Male; Myocardial Contraction; Myocardium; Nandrolone; Nandrolone Decanoate; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Swimming; Testosterone; Time Factors; Ventricular Function, Left; Ventricular Remodeling | 2007 |
Effects of angiotensin II blockade on the development of autoimmune thyroiditis in nonobese diabetic mice.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Disease Models, Animal; Enalapril; Hashimoto Disease; Losartan; Mice; Mice, Inbred NOD; Sodium Iodide; Thyroglobulin | 2008 |
[Ca2+]i and PKC-alpha are involved in the inhibitory effects of Ib, a novel nonpeptide AngiotensinII subtype AT1 receptor antagonist, on AngiotensinII-induced vascular contraction in vitro.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Calcium; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Protein Kinase C-alpha; Rabbits; Receptor, Angiotensin, Type 1; Tetrazoles; Triazoles | 2007 |
Effect of compound EXP-2528 on angiotensin II-induced E-selectin and VCAM-1 expression in rat brain microvascular endothelial cells in vitro.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Brain; Cells, Cultured; E-Selectin; Endothelial Cells; Imidazoles; Isoxazoles; Losartan; Microvessels; Rats; RNA, Messenger; Vascular Cell Adhesion Molecule-1 | 2007 |
The effect of angiotensin II and IV on ERK1/2 and CREB signalling in cultured rat astroglial cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Apoptosis; Astrocytes; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Imidazoles; Losartan; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oxidative Stress; Pyridines; Rats; Receptors, Angiotensin; Vasoconstrictor Agents | 2007 |
ACE mediates ventilator-induced lung injury in rats via angiotensin II but not bradykinin.
Topics: Angiotensin II; Animals; Apoptosis; Bradykinin; Bronchoalveolar Lavage Fluid; Captopril; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; In Situ Nick-End Labeling; Inflammation Mediators; Losartan; Lung Diseases; Male; Peptidyl-Dipeptidase A; Pulmonary Gas Exchange; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Respiration, Artificial; Sensitivity and Specificity | 2008 |
Captopril inhibits capillary degeneration in the early stages of diabetic retinopathy.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Glucose; Body Weight; Capillaries; Captopril; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelial Cells; Hyperglycemia; Leukostasis; Losartan; Male; Rats; Rats, Inbred Lew; Retina; Retinal Vessels; Vascular Cell Adhesion Molecule-1 | 2007 |
The role of angiotensin II in the early stages of bovine ovulation.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Cattle; Female; Gonadotropin-Releasing Hormone; Imidazoles; Injections; Losartan; Luteinizing Hormone; Ovarian Follicle; Ovulation; Pyridines; Random Allocation; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Saralasin; Ultrasonography | 2007 |
The role of local and systemic renin angiotensin system activation in a genetic model of sympathetic hyperactivity-induced heart failure in mice.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Blood Pressure; Disease Models, Animal; Heart Failure; Heart Rate; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Genetic; Myocytes, Cardiac; Norepinephrine; Physical Conditioning, Animal; Receptors, Adrenergic, alpha-2; Renin-Angiotensin System; Sympathetic Nervous System | 2008 |
The signalling of AT2 and the influence on the collagen metabolism of AT2 receptor in adult rat cardiac fibroblasts.
Topics: Angiotensin II; Animals; Collagen; Fibroblasts; Gene Expression; Immunohistochemistry; Losartan; Matrix Metalloproteinase 13; Myocardium; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; RNA, Messenger; Signal Transduction; Tissue Inhibitor of Metalloproteinase-1 | 2007 |
Angiotensin-(1-7) inhibits in vitro endothelial cell tube formation in human umbilical vein endothelial cells through the AT(1-7) receptor.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Antihypertensive Agents; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Imidazoles; Losartan; Neovascularization, Physiologic; Peptide Fragments; Pyridines; Receptors, Angiotensin; Umbilical Veins; Vasoconstrictor Agents | 2007 |
Angiotensin II induces vascular endothelial growth factor in pancreatic cancer cells through an angiotensin II type 1 receptor and ERK1/2 signaling.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Blotting, Western; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Disease Progression; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; Genistein; Humans; Imidazoles; Immunohistochemistry; Losartan; Mitogen-Activated Protein Kinase 1; Neovascularization, Pathologic; Pancreatic Neoplasms; Protein Kinase Inhibitors; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Signal Transduction; Vascular Endothelial Growth Factor A; Vasoconstrictor Agents | 2008 |
In vivo regulation of AT1a receptor-mediated intracellular uptake of [125I]Val5-ANG II in the kidneys and adrenals of AT1a receptor-deficient mice.
Topics: Adrenal Cortex; Adrenal Glands; Adrenal Medulla; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Captopril; Diuresis; Drinking; Endocytosis; Infusions, Intravenous; Kidney; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Potassium; Protein Isoforms; Receptor, Angiotensin, Type 1; Sodium | 2008 |
Role of the renin angiotensin system in TNF-alpha and Shiga-toxin-induced tissue factor expression.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Cells, Cultured; Dose-Response Relationship, Drug; Drug Combinations; Enalapril; Endothelium, Vascular; Humans; Imidazoles; Kidney Glomerulus; Losartan; Pyridines; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; RNA, Messenger; Shiga Toxin 1; Thromboplastin; Tumor Necrosis Factor-alpha; Up-Regulation | 2008 |
A novel adipokine CTRP1 stimulates aldosterone production.
Topics: Adipokines; Aldosterone; Angiotensin II; Animals; Calcium; Cytochrome P-450 CYP11B2; DNA-Binding Proteins; Humans; Hypertension; Losartan; Male; Nuclear Receptor Subfamily 4, Group A, Member 1; Nuclear Receptor Subfamily 4, Group A, Member 2; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured | 2008 |
Angiotensin II activates signal transducer and activators of transcription 3 via Rac1 in atrial myocytes and fibroblasts: implication for the therapeutic effect of statin in atrial structural remodeling.
Topics: Angiotensin II; Animals; Atrial Fibrillation; Cells, Cultured; Fibroblasts; Heart Atria; Humans; Losartan; Muscle Cells; Phosphorylation; rac1 GTP-Binding Protein; Rats; Rats, Wistar; Signal Transduction; Simvastatin; STAT3 Transcription Factor; Ventricular Remodeling | 2008 |
Assessment of brain AT1-receptor on the nocturnal basal and angiotensin-induced thirst and sodium appetite in ovariectomised rats.
Topics: Administration, Oral; Angiotensin I; Angiotensin II; Angiotensins; Animals; Antihypertensive Agents; Appetite; Brain; Circadian Rhythm; Darkness; Drinking; Estrogens; Female; Injections, Intraventricular; Losartan; Ovariectomy; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Sodium; Thirst | 2007 |
Hyperinsulinemic rats are normotensive but sensitized to angiotensin II.
Topics: Acetylcholine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Disease Models, Animal; Female; Ganglia, Sympathetic; Ganglionic Blockers; Glucose; Heart Rate; Hexamethonium; Hyperinsulinism; Hypertension; Insulin; Insulin Infusion Systems; Losartan; Myography; Rats; Rats, Sprague-Dawley; Renin; Renin-Angiotensin System; Telemetry; Time Factors; Vasodilation; Vasodilator Agents | 2008 |
Prenatal gender-related nicotine exposure increases blood pressure response to angiotensin II in adult offspring.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Body Weight; Calcium; Enzyme Inhibitors; Female; Imidazoles; Losartan; Mesenteric Arteries; Nicotine; Nicotinic Agonists; Nitroarginine; Pregnancy; Prenatal Exposure Delayed Effects; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sex Characteristics; Vasoconstriction; Vasoconstrictor Agents | 2008 |
Angiotensin II upregulates LDL receptor-related protein (LRP1) expression in the vascular wall: a new pro-atherogenic mechanism of hypertension.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Atherosclerosis; Cells, Cultured; Cholesterol Esters; Disease Models, Animal; Humans; Hypertension; Imidazoles; Lactoferrin; Losartan; Low Density Lipoprotein Receptor-Related Protein-1; Male; Muscle, Smooth, Vascular; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA Interference; RNA, Messenger; RNA, Small Interfering; Time Factors; Up-Regulation | 2008 |
Role of angiotensin II in the enhancement of ammonia production and secretion by the proximal tubule in metabolic acidosis.
Topics: Acidosis; Ammonia; Ammonium Chloride; Angiotensin II; Animals; Disease Models, Animal; Kidney Cortex; Kidney Tubules, Proximal; Losartan; Male; Mice; Perfusion | 2008 |
Anti-cancer actions of a recombinant antibody (R6313/G2) against the angiotensin II AT1 receptor.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Antibodies, Monoclonal; Apoptosis; Blood Pressure Determination; Blotting, Western; Breast Neoplasms; Caspases; Cell Survival; Female; Humans; Immunoglobulin Fragments; Losartan; Mice; Mice, Inbred BALB C; Peptide Fragments; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Recombinant Proteins; Tumor Cells, Cultured; Vasoconstrictor Agents; Xenograft Model Antitumor Assays | 2008 |
Coronary constriction to angiotensin II is enhanced by endothelial superoxide production in sheep programmed by dexamethasone.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Coronary Vessels; Dexamethasone; Endothelium, Vascular; Female; Glucocorticoids; Imidazoles; Losartan; NADP; Pregnancy; Prenatal Exposure Delayed Effects; Pyridines; Sheep; Superoxides; Vasoconstriction; Vasoconstrictor Agents | 2008 |
Angiotensin II regulates cardiac hypertrophy via oxidative stress but not antioxidant enzyme activities in experimental renovascular hypertension.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Catalase; Glutathione; Hypertension, Renovascular; Losartan; Male; NADPH Oxidases; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase | 2008 |
Angiotensin II- and glucose-stimulated extracellular matrix production: mediation by the insulin-like growth factor (IGF) axis in a murine mesangial cell line.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antibodies; Cell Line; Dose-Response Relationship, Drug; Extracellular Matrix; Glucose; Insulin-Like Growth Factor Binding Protein 2; Insulin-Like Growth Factor I; Losartan; Mesangial Cells; Mice; Receptor, Angiotensin, Type 1; Signal Transduction | 2008 |
Losartan improves impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type 1 diabetic rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Arterioles; Cerebral Arteries; Cerebrovascular Disorders; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Losartan; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Superoxides; Vasodilation | 2008 |
Inhibition of the rapid component of the delayed rectifier potassium current in ventricular myocytes by angiotensin II via the AT1 receptor.
Topics: Action Potentials; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arrhythmias, Cardiac; Cell Line; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Heart Ventricles; Humans; Indoles; Ion Channel Gating; Losartan; Maleimides; Myocytes, Cardiac; Patch-Clamp Techniques; Potassium; Protein Kinase C; Protein Kinase Inhibitors; Receptor, Angiotensin, Type 1; Signal Transduction; Staurosporine; Time Factors; Transfection | 2008 |
Prevention of salt-induced hypertension and fibrosis by AT1-receptor blockers in Dahl S rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Benzimidazoles; Benzoates; Blood Pressure; Cardiomegaly; Dose-Response Relationship, Drug; Fibrosis; Heart Rate; Hypertension; Hypertrophy; Kidney; Losartan; Male; Myocardium; Organ Specificity; Rats; Rats, Inbred Dahl; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sodium, Dietary; Telmisartan | 2008 |
The effect of angiotensin II on intracellular pH is mediated by AT(1) receptor translocation.
Topics: Amino Acid Sequence; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Base Sequence; Cell Line; Cell Membrane; Cytosol; Dogs; Egtazic Acid; Fluoresceins; Fluorescent Antibody Technique; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Losartan; Microscopy, Confocal; Molecular Sequence Data; Protein Transport; Receptor, Angiotensin, Type 1; Sodium-Hydrogen Exchangers; Transfection | 2008 |
Effect of ANG II on endothelial cell apoptosis and survival and its impact on skeletal muscle angiogenesis after electrical stimulation.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Proliferation; Cell Survival; Cells, Cultured; Electric Stimulation; Endothelial Cells; Infusions, Intravenous; Losartan; Mitochondria; Muscle, Skeletal; Neovascularization, Physiologic; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred Strains; Sodium Chloride, Dietary | 2008 |
Administration of angiotensin II in the paraventricular nucleus protects gastric mucosa from ischemia-reperfusion injury.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Gastric Mucosa; Losartan; Male; Paraventricular Hypothalamic Nucleus; Phentolamine; Propranolol; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sympathectomy; Time Factors; Vasoconstrictor Agents | 2008 |
Upregulation of AT2 receptor and iNOS impairs angiotensin II-induced contraction without endothelium influence in young normotensive diabetic rats.
Topics: Aging; Angiotensin II; Animals; Antihypertensive Agents; Diabetes Mellitus, Type 2; Endothelium, Vascular; Imidazoles; Losartan; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Pyridines; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 2; rho-Associated Kinases; Signal Transduction; Up-Regulation; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2008 |
ACE-dependent and chymase-dependent angiotensin II generation in normal and glucose-stimulated human mesangial cells.
Topics: Angiotensin II; Captopril; Cells, Cultured; Chymases; Diabetic Nephropathies; Glucose; Humans; Losartan; Mesangial Cells; Oligopeptides; Peptidyl-Dipeptidase A; RNA, Messenger | 2008 |
Angiotensin II relaxations of bovine adrenal cortical arteries: role of angiotensin II metabolites and endothelial nitric oxide.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenal Cortex; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin III; Animals; Arteries; Cattle; Endothelium, Vascular; Imidazoles; Losartan; Nitric Oxide; Peptide Fragments; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2008 |
Inhibition of Angiotensin II receptors during pregnancy induces malformations in developing rat kidney.
Topics: Abnormalities, Drug-Induced; Aging; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Animals, Newborn; Autoradiography; Female; Imidazoles; Kidney; Kidney Glomerulus; Losartan; Pregnancy; Pregnancy, Animal; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System | 2008 |
AT1 receptor participates in the cardiac hypertrophy induced by resistance training in rats.
Topics: Adaptation, Physiological; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blotting, Western; Body Weight; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hemodynamics; Hypertrophy, Left Ventricular; Losartan; Male; Muscle Strength; Myocardium; Physical Exertion; Polymerase Chain Reaction; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; RNA, Messenger; Sodium Chloride, Dietary; Up-Regulation | 2008 |
Upregulation of interleukin-8/CXCL8 in vascular smooth muscle cells from spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cells, Cultured; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Heme Oxygenase-1; Hypertension; Interleukin-8; Losartan; Male; Muscle, Smooth, Vascular; NF-kappa B; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; Signal Transduction; Transfection; Up-Regulation; Vasoconstrictor Agents | 2008 |
ETA-receptor blockade impairs vasoconstriction after hemorrhage in xenon-anesthetized dogs treated with an AT1-receptor antagonist.
Topics: Anesthesia; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Atrasentan; Blood Pressure; Dogs; Endothelin A Receptor Antagonists; Endothelin-1; Female; Hemodynamics; Hemorrhage; Losartan; Pyrrolidines; Vascular Resistance; Vasoconstriction; Vasopressins; Xenon | 2008 |
Increased colonic sodium absorption in rats with chronic renal failure is partially mediated by AT1 receptor agonism.
Topics: Amiloride; Angiotensin II; Animals; Colon; Epithelial Sodium Channels; Intestinal Absorption; Kidney Failure, Chronic; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Sodium; Sodium-Hydrogen Exchangers; Water-Electrolyte Balance | 2008 |
Characterization of angiotensin II antagonism displayed by Ib, a novel nonpeptide angiotensin AT(1) receptor antagonist.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Cattle; Cerebellum; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Injections, Intravenous; Liver; Losartan; Male; Protein Binding; Pyrroles; Rabbits; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Time Factors; Triazoles; Vasoconstriction | 2008 |
Losartan and ozagrel reverse retinal arteriolar constriction in non-obese diabetic mice.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arterioles; Blood Flow Velocity; Constriction, Pathologic; Female; Fibrinolytic Agents; Hyperglycemia; Losartan; Methacrylates; Mice; Mice, Inbred NOD; Retinal Vessels; Thromboxanes; Venules | 2008 |
Agonistic AT(1) receptor autoantibody increases in serum of patients with refractory hypertension and improves Ca(2+) mobilization in cultured rat vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Autoantibodies; Calcium; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Immunologic; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1 | 2008 |
Opposed effects of prostaglandin E2 on perfusion of rat renal cortex and medulla: interactions with the renin-angiotensin system.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cyclooxygenase Inhibitors; Dinoprostone; Indomethacin; Infusions, Intra-Arterial; Kidney Cortex; Kidney Medulla; Laser-Doppler Flowmetry; Losartan; Male; Misoprostol; Rats; Rats, Wistar; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Renal Artery; Renal Circulation; Renin-Angiotensin System; Ultrasonography; Vasoconstriction; Vasodilation | 2008 |
Involvement of AT(1) angiotensin receptors in the vasomodulatory effect of des-aspartate-angiotensin I in the rat renal vasculature.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Diabetes Mellitus, Experimental; Kidney; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1 | 2008 |
Area-specific differences in transmitter release in central catecholaminergic neurons of spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Brain Stem; Catecholamines; Disease Models, Animal; Dopamine beta-Hydroxylase; Electrophysiology; Hypertension; Losartan; Neurons; Norepinephrine; Phenethylamines; Probability; Random Allocation; Rats; Rats, Inbred SHR; Rats, Wistar; Reference Values; Sensitivity and Specificity | 2008 |
Phospholipase C/protein kinase C pathway mediates angiotensin II-dependent apoptosis in neonatal rat cardiac fibroblasts expressing AT1 receptor.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Apoptosis; Carbazoles; Cells, Cultured; Estrenes; Fibroblasts; Gene Expression; Losartan; Protein Kinase C; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Signal Transduction; Type C Phospholipases | 2008 |
Angiotensin II type 2 receptor-mediated inhibition of norepinephrine release in isolated rat hearts.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Bradykinin; Heart; Imidazoles; In Vitro Techniques; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Oligopeptides; Phenylalanine; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sympathetic Nervous System; Tranexamic Acid; Vasoconstrictor Agents | 2008 |
Sex differences in angiotensin signaling in bulbospinal neurons in the rat rostral ventrolateral medulla.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Age Factors; Angiotensin II; Animals; Calcium Channels, L-Type; Calcium Signaling; Estradiol; Female; Losartan; Male; Medulla Oblongata; NADPH Oxidases; Neurons; Nifedipine; Ovariectomy; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Sex Factors; Signal Transduction; Tyrosine 3-Monooxygenase | 2008 |
Inhibition of Ang II and renal sympathetic nerve influence dopamine-and isoprenaline-induced renal haemodynamic changes in normal Wistar-Kyoto and spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Dopamine; Hemodynamics; Hypertension; Isoproterenol; Kidney; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Renin-Angiotensin System; Sodium; Species Specificity; Sympathectomy; Sympathetic Nervous System; Sympathomimetics | 2008 |
The acute and chronic effects of losartan in heart failure.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Controlled Clinical Trials as Topic; Dose-Response Relationship, Drug; Heart Failure; Heart Rate; Humans; Losartan; Pulmonary Wedge Pressure; Renin; Treatment Outcome; Vascular Resistance | 1995 |
Use of angiotensin II antagonists in human heart failure: function of the subtype 1 receptor.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, Animal; Down-Regulation; Heart Failure; Humans; Losartan; Myocardium; Rats; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Renin-Angiotensin System | 1995 |
The role of nuclear factor-kappaB in the effect of angiotensin II in the paraventricular nucleus in protecting the gastric mucosa from ischemia-reperfusion injury in rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Dose-Response Relationship, Drug; Gastric Mucosa; I-kappa B Proteins; Losartan; Male; Malondialdehyde; NF-kappa B; NF-KappaB Inhibitor alpha; Paraventricular Hypothalamic Nucleus; Phosphorylation; Pyrrolidines; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Reperfusion Injury; Superoxide Dismutase; Thiocarbamates | 2008 |
Regulation of oxygen utilization by angiotensin II in chronic kidney disease.
Topics: Angiotensin II; Animals; Captopril; Disease Models, Animal; Kidney Diseases; Losartan; Nitric Oxide Synthase; Oxygen Consumption; Rats; Sodium | 2009 |
Loss of vitamin D receptor produces polyuria by increasing thirst.
Topics: Angiotensin II; Animals; Gene Expression Regulation; Losartan; Mice; Mice, Inbred C57BL; Polyuria; Proto-Oncogene Proteins c-fos; Receptors, Calcitriol; Renin; Reverse Transcriptase Polymerase Chain Reaction; Salts; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Thirst; Up-Regulation | 2008 |
ADMA impairs nitric oxide-mediated arteriolar function due to increased superoxide production by angiotensin II-NAD(P)H oxidase pathway.
Topics: Acetophenones; Angiotensin II; Animals; Arginine; Arterioles; Enzyme Inhibitors; Losartan; Male; Muscle, Skeletal; NADPH Oxidases; Nitric Oxide; Oxidative Stress; Quinapril; Rats; Rats, Wistar; Signal Transduction; Superoxides; Tetrahydroisoquinolines; Vasoconstriction; Vasodilation | 2008 |
Regulation of ACE2 in cardiac myocytes and fibroblasts.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Animals, Newborn; Atrial Natriuretic Factor; Butadienes; Cells, Cultured; Endothelin-1; Fibroblasts; Flavonoids; Gene Expression Regulation, Enzymologic; Heart Ventricles; Losartan; Mitogen-Activated Protein Kinase 1; Myocytes, Cardiac; Nitriles; Peptide Fragments; Peptidyl-Dipeptidase A; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction | 2008 |
Pulsatile stretch induces release of angiotensin II and oxidative stress in human endothelial cells: effects of ACE inhibition and AT1 receptor antagonism.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Biomechanical Phenomena; Cells, Cultured; Endothelial Cells; Hemorheology; Humans; Losartan; Models, Biological; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Pulsatile Flow; Renin-Angiotensin System; Stress, Mechanical; Superoxides; Tetrahydroisoquinolines | 2008 |
Effect of unilateral ureteral obstruction and anti-angiotensin II treatment on renal tubule and interstitial cell apoptosis in rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Apoptosis; Caspase 3; Cell Proliferation; Cell Survival; Cell Transdifferentiation; Cilazapril; Disease Models, Animal; Epithelial Cells; Kidney Tubules; Losartan; Male; Rats; Rats, Wistar; Ureteral Obstruction | 2008 |
[Angiotensin II type 2 receptor expression and its modulation in angiotensin II induced acute lung injury in rat].
Topics: Acute Lung Injury; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, Animal; Losartan; Lung; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; RNA, Messenger | 2008 |
Losartan, an antagonist of AT1 receptor for angiotensin II, attenuates lipopolysaccharide-induced acute lung injury in rat.
Topics: Acute Lung Injury; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Lipopolysaccharides; Losartan; Lung; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Tumor Necrosis Factor-alpha | 2009 |
Angiotensin II-mediated vasodilation is reduced in adult spontaneously hypertensive rats despite enhanced expression of AT2 receptors.
Topics: Acetylcholine; Aging; Angiotensin II; Animals; Blotting, Western; Bradykinin; Gene Expression Regulation; Imidazoles; Losartan; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptide Fragments; Pyridines; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 2; Vasodilation | 2009 |
Blockade of AT1 receptor partially restores vasoreactivity, NOS expression, and superoxide levels in cerebral and carotid arteries of hindlimb unweighting rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Basilar Artery; Carotid Artery, Common; Dose-Response Relationship, Drug; Hindlimb Suspension; Losartan; Male; Models, Animal; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Superoxides; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Weightlessness Simulation | 2009 |
Involvement of prolylcarboxypeptidase in the effect of rutaecarpine on the regression of mesenteric artery hypertrophy in renovascular hypertensive rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Carboxypeptidases; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Renovascular; Hypertrophy; Indole Alkaloids; Kallikreins; Losartan; Male; Mesenteric Arteries; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation | 2009 |
Diabetic state, high plasma insulin and angiotensin II combine to augment endothelin-1-induced vasoconstriction via ETA receptors and ERK.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Endothelin A Receptor Antagonists; Endothelin-1; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Hypertension; Insulin; Losartan; Male; Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Receptor, Endothelin A; Streptozocin; Vasoconstriction | 2008 |
Regulation of T-cell function by endogenously produced angiotensin II.
Topics: Adoptive Transfer; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensinogen; Animals; Autocrine Communication; Blood Pressure; Catalase; Cells, Cultured; Homeodomain Proteins; Imidazoles; Infusion Pumps, Implantable; Losartan; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Peptidyl-Dipeptidase A; Polyethylene Glycols; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin; Renin-Angiotensin System; Superoxide Dismutase; Superoxides; T-Lymphocytes; Time Factors; Tumor Necrosis Factor-alpha | 2009 |
Apoptosis-dependent acute pulmonary injury after intratracheal instillation of angiotensin II.
Topics: Amino Acid Chloromethyl Ketones; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Epithelial Cells; Losartan; Lung Injury; Male; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1 | 2008 |
[Mechanisms of losartan for inhibition of myocardial fibrosis following myocardial infarction in rats].
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Fibrosis; Losartan; Male; Myocardial Infarction; Myocardium; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; RNA, Messenger | 2008 |
Microinjection of angiotensin II in the caudal ventrolateral medulla induces hyperalgesia.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cholera Toxin; Hyperalgesia; Losartan; Male; Medulla Oblongata; Microinjections; Neural Pathways; Neurons; Pain Measurement; Rats; Rats, Wistar; Reaction Time; Receptor, Angiotensin, Type 1; Spinal Cord; Vasoconstrictor Agents | 2009 |
Increased vascular angiotensin type 2 receptor expression and NOS-mediated mechanisms of vascular relaxation in pregnant rats.
Topics: Acetylcholine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Imidazoles; Losartan; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase Type III; Oligopeptides; Phenylephrine; Phosphorylation; Pregnancy; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Up-Regulation; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2009 |
Influence of sympathetic and AT-receptor blockade on angiotensin II and adrenergic agonist-induced renal vasoconstrictions in spontaneously hypertensive rats.
Topics: Adrenergic Agonists; Adrenergic alpha-Antagonists; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Carbazoles; Carvedilol; Drug Interactions; Hypertension; Kidney; Losartan; Male; Propanolamines; Rats; Rats, Inbred SHR; Renal Circulation; Sympathetic Nervous System; Vasoconstriction; Vasoconstrictor Agents | 2009 |
Inhibition of angiotensin type 1 receptor impairs renal ability of K conservation in response to K restriction.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; CSK Tyrosine-Protein Kinase; Female; Homeostasis; Kidney; Losartan; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Potassium; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; src-Family Kinases; Superoxides | 2009 |
Involvement of redox-sensitive extracellular-regulated kinases in angiotensin II-induced interleukin-6 expression in pancreatic acinar cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blotting, Western; Cell Line; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Interleukin-6; Losartan; Oxidation-Reduction; Pancreas; Pancreatitis; Phosphorylation; Rats; Rats, Wistar; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Cardiovascular and autonomic phenotype of db/db diabetic mice.
Topics: Aging; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Autonomic Nervous System; Baroreflex; Blood Pressure; Cardiovascular System; Circadian Rhythm; Diabetes Complications; Diabetes Mellitus, Type 2; Disease Models, Animal; Heart Rate; Hypertension; Losartan; Male; Mice; Mice, Mutant Strains; Motor Activity; Peptidyl-Dipeptidase A; Phenotype; Receptor, Angiotensin, Type 1; Receptors, Leptin | 2009 |
Effects of apocynin and losartan treatment on renal oxidative stress in a rat model of calcium oxalate nephrolithiasis.
Topics: Acetophenones; Analysis of Variance; Angiotensin II; Animals; Antioxidants; Biopsy, Needle; Blotting, Western; Calcium Oxalate; Disease Models, Animal; Immunohistochemistry; Losartan; Male; NADPH Oxidases; Nephrolithiasis; Oxidative Stress; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Urinalysis | 2009 |
Synergism of simvastatin with losartan prevents angiotensin II-induced cardiomyocyte apoptosis in vitro.
Topics: Angiotensin II; Animals; Animals, Newborn; Apoptosis; bcl-2-Associated X Protein; Cell Culture Techniques; Cell Survival; Drug Synergism; Losartan; Myocytes, Cardiac; Proto-Oncogene Proteins c-bcl-2; Rats; Simvastatin | 2009 |
Protective effects of angiotensin AT1 receptor blockade in malignant hypertension in the rat.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Atrasentan; Blood Pressure; Endothelin-1; Hydralazine; Hypertension, Malignant; Losartan; Male; Necrosis; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renal Insufficiency | 2009 |
Impairment of the autoregulation of renal hemodynamics and of the pressure-natriuresis relationship precedes the development of hypertension in Cyp1a1-Ren-2 transgenic rats.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cytochrome P-450 CYP1A1; Glomerular Filtration Rate; Hemodynamics; Homeostasis; Hypertension; Indoles; Kidney; Losartan; Male; Natriuresis; Rats; Rats, Transgenic; Receptor, Angiotensin, Type 1; Renal Circulation; Renin; Renin-Angiotensin System; Sodium; Time Factors | 2009 |
Angiotensin II directly regulates intestinal epithelial NHE3 in Caco2BBE cells.
Topics: Angiotensin II; Animals; Cell Line; Cell Polarity; Enzyme Inhibitors; Epithelial Cells; Exocytosis; Gene Expression Regulation; Genes, Reporter; Humans; Intestinal Mucosa; Ion Transport; Losartan; Microvilli; Promoter Regions, Genetic; Rats; Receptor, Angiotensin, Type 1; RNA, Messenger; Sodium; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Time Factors | 2009 |
Endogenous angiotensin II has fewer effects but neuronal nitric oxide synthase has excitatory effects on renal sympathetic nerve activity in salt-sensitive hypertension-induced heart failure.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Brain; Citrulline; Enzyme Inhibitors; Heart Failure; Hypertension; Kidney; Losartan; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pressoreceptors; Rats; Rats, Inbred Dahl; Renin-Angiotensin System; Sodium Chloride, Dietary; Sympathetic Nervous System; Thiourea | 2009 |
Enhanced cardiac sympathetic afferent reflex involved in sympathetic overactivity in renovascular hypertensive rats.
Topics: Angiotensin II; Animals; Aortic Coarctation; Hypertension, Renovascular; Injections, Intravenous; Injections, Intraventricular; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Reflex; Sympathetic Nervous System | 2009 |
Noninvasive imaging of angiotensin receptors after myocardial infarction.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Binding Sites; Biomarkers; Disease Models, Animal; Feasibility Studies; Fluorescent Dyes; Heart Failure; Losartan; Male; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Microscopy, Fluorescence, Multiphoton; Microscopy, Video; Myocardial Infarction; Myocardium; Radiopharmaceuticals; Receptors, Angiotensin; Technetium; Time Factors; Tomography, Emission-Computed, Single-Photon; Ventricular Remodeling; X-Ray Microtomography | 2008 |
AT(1) receptor activation regulates the mRNA expression of CAT1, CAT2, arginase-1, and DDAH2 in preglomerular vessels from angiotensin II hypertensive rats.
Topics: Amidohydrolases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arginase; Arterioles; Calcium Channels; Disease Models, Animal; Hypertension; Kidney Glomerulus; Losartan; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; RNA, Messenger; TRPV Cation Channels | 2009 |
Long-term regulation of vacuolar H(+)-ATPase by angiotensin II in proximal tubule cells.
Topics: Ammonium Chloride; Androstadienes; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Buffers; Cell Line, Transformed; Cell Membrane; Cycloheximide; Dactinomycin; Epithelial Cells; Gene Expression; Genistein; Hydrogen-Ion Concentration; Imidazoles; Kidney Tubules, Proximal; Losartan; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Subunits; Protein Transport; Protein-Tyrosine Kinases; Pyridines; Rats; Time Factors; Up-Regulation; Vacuolar Proton-Translocating ATPases; Wortmannin | 2009 |
[Effect of cordyceps sinensis extract on Klotho expression and apoptosis in renal tubular epithelial cells induced by angiotensin II].
Topics: Angiotensin II; Apoptosis; Caspase 3; Cells, Cultured; Cordyceps; Cyclin-Dependent Kinase Inhibitor p21; Drugs, Chinese Herbal; Epithelial Cells; Glucuronidase; Humans; Kidney Tubules; Klotho Proteins; Losartan; RNA, Messenger; Tumor Suppressor Protein p53 | 2009 |
Effect of early versus late AT(1) receptor blockade with losartan on postmyocardial infarction ventricular remodeling in rabbits.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Body Weight; Collagen; Losartan; Lymphocytes; Macrophages; Muscle Cells; Myocardial Infarction; Myocardium; Neutrophil Infiltration; Organ Size; Rabbits; Receptor, Angiotensin, Type 1; Survival Analysis; Ventricular Remodeling | 2009 |
Angiotensin II up-regulates PAX2 oncogene expression and activity in prostate cancer via the angiotensin II type I receptor.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Inhibitors; Humans; Losartan; Male; PAX2 Transcription Factor; Phosphorylation; Prostate; Prostatic Neoplasms; Receptor, Angiotensin, Type 2; RNA, Messenger; Signal Transduction; Up-Regulation | 2009 |
The uterine placental bed Renin-Angiotensin system in normal and preeclamptic pregnancy.
Topics: Alanine; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Down-Regulation; Female; Gene Expression; Humans; Imidazoles; Losartan; Peptide Fragments; Peptidyl-Dipeptidase A; Placenta; Pre-Eclampsia; Pregnancy; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Stereoisomerism; Uterus | 2009 |
Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: strong synergism with AT1 receptor antagonist.
Topics: Albuminuria; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Cytokines; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ergocalciferols; Fibrosis; Glomerular Basement Membrane; Inflammation Mediators; Losartan; Macrophages; Mice; Mice, Inbred DBA; Podocytes; Renin; Renin-Angiotensin System; Time Factors; Vitamins | 2009 |
Immunosuppressive effect of angiotensin receptor blocker on stimulation of mice CTLs by angiotensin II.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Line; Cytotoxicity, Immunologic; Epitopes, T-Lymphocyte; H-2 Antigens; Histocompatibility Antigen H-2D; HLA-A2 Antigen; Immunization; Interferon-gamma; Losartan; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Peptide Fragments; Receptor, Angiotensin, Type 1; T-Lymphocytes, Cytotoxic; Tumor Necrosis Factor-alpha | 2009 |
Losartan counteracts the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta, Thoracic; Biphenyl Compounds; Diabetes Mellitus, Experimental; In Vitro Techniques; Irbesartan; Losartan; Male; Rats; Rats, Wistar; rho-Associated Kinases; Tetrazoles; Up-Regulation; Vasoconstriction | 2009 |
Regulation of glucose uptake in mesangial cells stimulated by high glucose: role of angiotensin II and insulin.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Fibronectins; Gene Expression Regulation; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Humans; Insulin; Losartan; Male; Mesangial Cells; Rats; Rats, Wistar; Time Factors | 2009 |
Na(+)-ATPase in spontaneous hypertensive rats: possible AT(1) receptor target in the development of hypertension.
Topics: Angiotensin II; Animals; Enzyme Activation; Hypertension; Kidney Tubules, Proximal; Kinetics; Losartan; Male; Ouabain; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Sodium-Potassium-Exchanging ATPase | 2010 |
Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Bradycardia; Heart Rate; Hypertension; Losartan; Male; Medulla Oblongata; Microinjections; Peptide Fragments; Rats; Rats, Inbred F344 | 2009 |
Endogenous angiotensin II modulates nNOS expression in renovascular hypertension.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cyclic N-Oxides; Disease Models, Animal; Hypertension, Renovascular; Losartan; Male; NADPH Oxidases; Nitric Oxide Synthase Type I; Oxidative Stress; Rats; Rats, Wistar; Spin Labels | 2009 |
Effect of adrenotensin on cell proliferation is mediated by angiotensin II in cultured rat mesangial cells.
Topics: Adrenomedullin; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Cell Line; Cell Proliferation; Collagen Type IV; Gene Expression Regulation; Losartan; Mesangial Cells; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Receptor, Angiotensin, Type 1; Renin; RNA, Messenger; Transforming Growth Factor beta1 | 2009 |
Comparative antihypertensive activities of losartan and HM70186 in rats with hepatic dysfunction.
Topics: Administration, Oral; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Liver Diseases; Losartan; Male; Rats; Rats, Wistar; Time Factors | 2009 |
Enhanced angiotensin-mediated excitation of renal sympathetic nerve activity within the paraventricular nucleus of anesthetized rats with heart failure.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Disease Models, Animal; Heart Failure; Heart Rate; Kidney; Ligation; Losartan; Male; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; RNA, Messenger; Sympathetic Nervous System; Unconsciousness; Vasoconstrictor Agents | 2009 |
Rosuvastatin attenuates Ang II--mediated cardiomyocyte hypertrophy via inhibition of LOX-1.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Culture Techniques; Cell Size; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Losartan; Mice; Myocytes, Cardiac; NADP; NF-kappa B p50 Subunit; Pyrimidines; Receptor, Angiotensin, Type 1; RNA, Messenger; Rosuvastatin Calcium; Scavenger Receptors, Class E; Sulfonamides; Transfection; Up-Regulation | 2009 |
Angiotensin III modulates the nociceptive control mediated by the periaqueductal gray matter.
Topics: Analgesics; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Disease Models, Animal; Drug Interactions; Efferent Pathways; Glutamyl Aminopeptidase; Losartan; Male; Microinjections; Neural Inhibition; Nociceptors; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Peptides; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Angiotensin | 2009 |
Vasopressin is a major vasoconstrictor involved in hindlimb vascular responses to stimulation of adenosine A(1) receptors in the nucleus of the solitary tract.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adrenalectomy; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Baroreflex; Blood Pressure; Heart Rate; Hindlimb; Iliac Artery; Losartan; Male; Microinjections; Muscle, Skeletal; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Angiotensin, Type 1; Receptors, Vasopressin; Regional Blood Flow; Solitary Nucleus; Sympathectomy; Time Factors; Vasoconstriction; Vasopressins | 2009 |
Ischemia-induced brain damage is enhanced in human renin and angiotensinogen double-transgenic mice.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Blood Pressure; Brain; Brain Ischemia; Cell Death; Disease Models, Animal; Humans; Infarction, Middle Cerebral Artery; Losartan; Male; Mice; Mice, Transgenic; Receptor, Angiotensin, Type 1; Regional Blood Flow; Renin; Severity of Illness Index; Signal Transduction | 2009 |
Angiotensin II and hypertonicity modulate proximal tubular aquaporin 1 expression.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aquaporin 1; Cell Line, Transformed; Diuresis; Dose-Response Relationship, Drug; Drug Synergism; Hypertonic Solutions; Imidazoles; Kidney; Kidney Tubules, Proximal; Loop of Henle; Losartan; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Chloride; Tetrazoles; Time Factors | 2009 |
Angiotensin II receptors are expressed and functional in human esophageal mucosa.
Topics: Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin Receptor Antagonists; Benzimidazoles; Biopsy; Biphenyl Compounds; Blood Vessels; Electric Impedance; Electrophysiological Phenomena; Epithelial Cells; Esophagus; Female; Gene Expression; Humans; Hydrochloric Acid; Imidazoles; Losartan; Male; Middle Aged; Mucous Membrane; Peptidyl-Dipeptidase A; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles | 2009 |
[NADPH oxidase-derived reactive oxygen species involved in angiotensin II-induced monocyte chemoattractant protein-1 expression in mesangial cells].
Topics: Acetophenones; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cells, Cultured; Chemokine CCL2; Dose-Response Relationship, Drug; Humans; Losartan; Male; Mesangial Cells; Mice; Mice, Inbred C57BL; NADPH Oxidases; Onium Compounds; Oxidative Stress; Phosphoproteins; Protein Transport; Random Allocation; Reactive Oxygen Species | 2009 |
Angiotensin II effects on ischemic focal ventricular tachycardia are predominantly mediated through myocardial AT(2) receptor.
Topics: Action Potentials; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Disease Models, Animal; Dogs; Electrocardiography; Electrophysiologic Techniques, Cardiac; Endocardium; Female; Imidazoles; Infusions, Intravenous; Losartan; Male; Myocardial Ischemia; Myocardium; Purkinje Fibers; Pyridines; Receptor, Angiotensin, Type 2; Signal Transduction; Tachycardia, Ventricular; Time Factors | 2009 |
Angiotensin II signaling via type 2 receptors in a human model of vascular hyporeactivity: implications for hypertension.
Topics: Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Bartter Syndrome; Cells, Cultured; Drug Combinations; Dual Specificity Phosphatase 1; Female; Fibroblasts; Gitelman Syndrome; Humans; Hypertension; Imidazoles; Losartan; Male; MAP Kinase Signaling System; Middle Aged; Mitogen-Activated Protein Kinase 3; Phosphorylation; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2 | 2010 |
Expression and distribution of NADPH oxidase isoforms in human myometrium--role in angiotensin II-induced hypertrophy.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Cell Line; Female; Gene Expression; Humans; Hypertrophy; Isoenzymes; Leucine; Losartan; Myometrium; NADPH Oxidases; Pregnancy; Protein Biosynthesis; Receptor, Angiotensin, Type 1; Tritium | 2010 |
Angiotensin II regulates the expression of monocyte chemoattractant protein-1 in pancreatic cancer cells.
Topics: Adenocarcinoma; Angiotensin II; Blotting, Western; Cell Line, Tumor; Chemokine CCL2; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Humans; Immunohistochemistry; Inflammation; Losartan; NF-kappa B; Pancreatic Neoplasms; Promoter Regions, Genetic; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured | 2009 |
Losartan-antioxidant hybrids: novel molecules for the prevention of hypertension-induced cardiovascular damage.
Topics: Alcohols; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Blood Pressure; Cardiovascular Diseases; Cells, Cultured; Collagen Type I; Esters; Fibronectins; Humans; Hypertension; Losartan; Male; Oxidative Stress; Rats; Rats, Wistar | 2009 |
Effect of acute stress on sexual behavior in female rats: participation of the central angiotensinergic system.
Topics: Acute Disease; Amygdala; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Female; Imidazoles; Losartan; Motor Activity; Oocytes; Proestrus; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Restraint, Physical; Sexual Behavior, Animal; Stress, Psychological; Time Factors | 2010 |
Angiotensin II exerts glucose-dependent effects on Kv currents in mouse pancreatic beta-cells via angiotensin II type 2 receptors.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Cells, Cultured; Glucose; Imidazoles; Insulin; Insulin-Secreting Cells; Ion Channel Gating; Losartan; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Potassium; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; RNA, Messenger; Shab Potassium Channels; Signal Transduction; Time Factors | 2010 |
Angiotensin II up-regulates CX3CR1 expression in THP-1 monocytes: impact on vascular inflammation and atherogenesis.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Atherosclerosis; Cell Adhesion; Cell Movement; Chemokine CX3CL1; CX3C Chemokine Receptor 1; Endothelial Cells; Gene Expression Regulation; Humans; Inflammation; Jurkat Cells; Losartan; Monocytes; Receptors, CCR5; Receptors, Chemokine; Receptors, CXCR4; Vasculitis; Vasoconstrictor Agents | 2010 |
Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme 2; Animals; Blotting, Western; Enzyme Inhibitors; Female; Imidazoles; Kidney Cortex; Leucine; Losartan; Peptide Fragments; Peptidyl-Dipeptidase A; Pyridines; Reactive Oxygen Species; Receptors, Angiotensin; Sheep; Time Factors | 2010 |
Angiotensin II type 1 and type 2 receptors regulate basal skeletal muscle microvascular volume and glucose use.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Flow Velocity; Blood Glucose; Blood Pressure Determination; Blood Volume; Disease Models, Animal; Imidazoles; Infusions, Intravenous; Losartan; Male; Microcirculation; Muscle, Skeletal; Probability; Pyridines; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Vasoconstrictor Agents | 2010 |
Angiotensin II induces a region-specific hyperplasia of the ascending aorta through regulation of inhibitor of differentiation 3.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Pressure; Hyperplasia; Hypertension; Inhibitor of Differentiation Proteins; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Norepinephrine; Organ Specificity; Receptor, Angiotensin, Type 1; Renin; Tunica Media | 2010 |
Contribution of epidermal growth factor receptor transactivation in angiotensin II-induced enhanced expression of Gi protein and proliferation in A10 vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Blotting, Western; Cell Line; Cell Proliferation; ErbB Receptors; GTP-Binding Protein alpha Subunits, Gi-Go; Imidazoles; Losartan; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Pyridines; Quinazolines; Rats; Receptors, Angiotensin; Transcriptional Activation; Tyrphostins | 2009 |
Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Apoptosis; Blood Pressure; Cell Proliferation; Cells, Cultured; Chronic Disease; Collagen; Disease Models, Animal; Fibrinolysin; Fibrosis; Glomerular Filtration Rate; Imidazoles; Kidney; Kidney Diseases; Losartan; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nephrectomy; Phosphorylation; Plasminogen Activator Inhibitor 1; Podocytes; Proteinuria; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; RNA, Messenger; Time Factors | 2010 |
Angiotensin II inhibits neuronal nitric oxide synthase activation through the ERK1/2-RSK signaling pathway to modulate central control of blood pressure.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Cyclic N-Oxides; Disease Models, Animal; Enzyme Activation; Flavonoids; Hypertension; Losartan; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidative Stress; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Inbred SHR; Reactive Oxygen Species; Ribosomal Protein S6 Kinases; Signal Transduction; Solitary Nucleus; Spin Labels; Time Factors | 2010 |
Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 during cardiac remodelling in rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis Regulatory Proteins; Cells, Cultured; Cytokine TWEAK; Gene Expression; Inflammation; Losartan; Male; Membrane Proteins; Myocardial Infarction; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor; RNA, Messenger; Signal Transduction; Stress, Mechanical; Tumor Necrosis Factors; TWEAK Receptor; Ventricular Remodeling | 2010 |
Receptor activity-modifying protein 1 increases baroreflex sensitivity and attenuates Angiotensin-induced hypertension.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Autonomic Nervous System Diseases; Baroreflex; Blood Pressure; Calcitonin Gene-Related Peptide; Gene Expression; Heart Rate; Humans; Hypertension; Intracellular Signaling Peptides and Proteins; Losartan; Male; Membrane Proteins; Mice; Mice, Transgenic; Parasympathetic Nervous System; Phenotype; Receptor Activity-Modifying Protein 1; Receptor Activity-Modifying Proteins; Receptor, Angiotensin, Type 1; Vasoconstrictor Agents | 2010 |
Fibronectin synthesis by high glucose level mediated proliferation of mouse embryonic stem cells: Involvement of ANG II and TGF-beta1.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Calcium Signaling; Cell Count; Cell Proliferation; DNA Replication; Embryonic Stem Cells; Fibronectins; Glucose; Hyperglycemia; JNK Mitogen-Activated Protein Kinases; Losartan; Mice; Phosphorylation; Protein Kinase C; Receptor, Angiotensin, Type 1; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta1 | 2010 |
[Protective effect of losartan on insulin secretion function of RIN-m cells against angiotensin II-induced injury and the mechanism].
Topics: Angiotensin II; Animals; Antihypertensive Agents; Cell Line, Tumor; Insulin-Secreting Cells; Insulinoma; Ion Channels; Losartan; Mitochondrial Proteins; Protective Agents; Rats; RNA, Messenger; Uncoupling Protein 2 | 2010 |
Importance of angiotensinergic mechanisms for the pressor response to l-glutamate into the rostral ventrolateral medulla.
Topics: Angiotensin II; Angiotensins; Animals; Anti-Arrhythmia Agents; Autonomic Pathways; Blood Pressure; Cardiovascular Physiological Phenomena; Glutamic Acid; Losartan; Male; Medulla Oblongata; Naphthyridines; Rats; Rats, Sprague-Dawley; Reticular Formation; Sympathetic Nervous System; Vasoconstriction | 2010 |
Chronic intermittent hypoxia augments chemoreflex control of sympathetic activity: role of the angiotensin II type 1 receptor.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apnea; Blood Pressure; Carotid Body; Chemoreceptor Cells; Gene Expression Regulation; Hypoxia; Losartan; Male; NADPH Oxidases; Nitric Oxide Synthase Type I; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Superoxides; Sympathetic Nervous System | 2010 |
Angiotensin-(1-7) and angiotension II in the rostral ventrolateral medulla modulate the cardiac sympathetic afferent reflex and sympathetic activity in rats.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Losartan; Male; Medulla Oblongata; Peptide Fragments; Rats; Rats, Sprague-Dawley | 2010 |
Astroglia are a possible cellular substrate of angiotensin(1-7) effects in the rostral ventrolateral medulla.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Astrocytes; Biosensing Techniques; Blood Pressure; Calcium Signaling; Catecholamines; Disease Models, Animal; Genes, Reporter; Hypertension; Losartan; Medulla Oblongata; Membrane Potentials; Microscopy, Confocal; Patch-Clamp Techniques; Peptide Fragments; Rats; Rats, Inbred SHR; Rats, Wistar; Tissue Culture Techniques | 2010 |
Involvement of the renin-angiotensin system in the development of vascular damage in a rat model of arthritis: effect of angiotensin receptor blockers.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Arthritis, Experimental; Biphenyl Compounds; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Vascular; Gene Expression; Hypertrophy; Irbesartan; Losartan; Male; Oxidative Stress; Rats; Rats, Inbred Lew; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Risk Reduction Behavior; Tetrazoles; Vasoconstrictor Agents | 2010 |
AT1 receptor blockade prevents the increase in blood pressure and the augmentation of intrarenal ANG II levels in hypertensive Cyp1a1-Ren2 transgenic rats fed with a high-salt diet.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Cytochrome P-450 CYP1A1; Hypertension; Kidney; Losartan; Male; Mice; Rats; Rats, Transgenic; Receptor, Angiotensin, Type 1; Renin; Sodium Chloride, Dietary | 2010 |
Repeated administration of angiotensin II reduces its dipsogenic effect without affecting saline intake.
Topics: Angiotensin II; Animals; Drinking; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Saline Solution, Hypertonic | 2010 |
Does enhanced respiratory-sympathetic coupling contribute to peripheral neural mechanisms of angiotensin II-salt hypertension?
Topics: Angiotensin II; Animals; Hypertension; Losartan; Medulla Oblongata; Rats; Receptor, Angiotensin, Type 1; Sodium Chloride, Dietary; Sympathetic Nervous System | 2010 |
Different protective actions of losartan and tempol on the renal inflammatory response to acute sodium overload.
Topics: Actins; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Blood Pressure; Chemokine CCL5; Cyclic N-Oxides; Disease Models, Animal; Glomerular Filtration Rate; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation Mediators; Kidney; Losartan; Male; Natriuresis; Nephritis; NF-kappa B; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Saline Solution, Hypertonic; Spin Labels; Time Factors; Transforming Growth Factor beta1; Water-Electrolyte Imbalance | 2010 |
High-dose versus low-dose losartan in patients with heart failure.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Heart Failure; Humans; Losartan; Myocardium; Stem Cells | 2010 |
Effect of ACE2 and angiotensin-(1-7) in a mouse model of early chronic kidney disease.
Topics: Albuminuria; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Body Weight; Chronic Disease; Disease Models, Animal; Glomerular Filtration Rate; Hematocrit; Imidazoles; Infusion Pumps; Injections, Subcutaneous; Inulin; Kidney; Kidney Diseases; Leucine; Losartan; Male; Mice; Nephrectomy; Organ Size; Peptide Fragments; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Time Factors | 2010 |
[Effect of iron overload on experimental immunological liver injury in rats and the role of angiotensin].
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Chemical and Drug Induced Liver Injury; Iron; Iron Overload; Lipopolysaccharides; Losartan; Male; Mycobacterium bovis; Random Allocation; Rats; Rats, Wistar | 2010 |
Angiotensin II signaling through the AT1a and AT1b receptors does not have a role in the development of cerulein-induced chronic pancreatitis in the mouse.
Topics: Actins; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Atrophy; Ceruletide; Collagen; Disease Models, Animal; Fibrosis; Losartan; Mice; Mice, Inbred C57BL; Mice, Knockout; Pancreas; Pancreatitis, Chronic; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; RNA, Messenger; Severity of Illness Index; Signal Transduction | 2010 |
Curcumin reduces angiotensin II-mediated cardiomyocyte growth via LOX-1 inhibition.
Topics: Angiotensin II; Animals; Antibodies; Atrial Natriuretic Factor; Cell Enlargement; Cell Line, Transformed; Cell Proliferation; Cell Survival; Curcumin; Gene Expression; Losartan; Membrane Glycoproteins; Mice; Myocytes, Cardiac; NADPH Oxidase 2; NADPH Oxidases; Natriuretic Peptide, Brain; NF-kappa B; Oxidative Stress; Protein Subunits; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Scavenger Receptors, Class E; Signal Transduction; Transfection | 2010 |
A single-nucleotide polymorphism of alanine to threonine at position 163 of the human angiotensin II type 1 receptor impairs Losartan affinity.
Topics: Alanine; Angiotensin II; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Blood Pressure; Chlorocebus aethiops; COS Cells; Humans; Imidazoles; Inositol Phosphates; Irbesartan; Losartan; Polymorphism, Single Nucleotide; Receptor, Angiotensin, Type 1; Telmisartan; Tetrazoles; Threonine; Valine; Valsartan | 2010 |
Angiotensin II/angiotensin II type I receptor (AT1R) signaling promotes MCF-7 breast cancer cells survival via PI3-kinase/Akt pathway.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Imidazoles; Losartan; Morpholines; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Receptor, Angiotensin, Type 1; Signal Transduction; Vasoconstrictor Agents | 2010 |
Sirolimus and everolimus reduce albumin endocytosis in proximal tubule cells via an angiotensin II-dependent pathway.
Topics: Albumins; Angiotensin II; Cell Line; Down-Regulation; Drug Therapy, Combination; Endocytosis; Epithelial Cells; Everolimus; Humans; Immunosuppressive Agents; Kidney Tubules, Proximal; Losartan; Low Density Lipoprotein Receptor-Related Protein-2; Ramipril; Receptor, Angiotensin, Type 1; Receptors, Cell Surface; Signal Transduction; Sirolimus | 2010 |
Antihypertensive activity of Salvia elegans Vahl. (Lamiaceae): ACE inhibition and angiotensin II antagonism.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Chromatography, Thin Layer; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Injections, Intravenous; Kinetics; Lisinopril; Losartan; Mice; Mice, Inbred ICR; Peptidyl-Dipeptidase A; Plant Components, Aerial; Plant Extracts; Salvia; Spectrophotometry, Ultraviolet | 2010 |
Simvastatin reduces pressor response to centrally administered angiotensin II.
Topics: Angiotensin II; Animals; Blood Pressure; Brain; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Losartan; Male; Rats; Rats, Sprague-Dawley; Simvastatin | 2010 |
Losartan inhibits LPS-induced inflammatory signaling through a PPARgamma-dependent mechanism in human THP-1 macrophages.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Atherosclerosis; Cell Line; Gene Expression; Humans; Hypertension; I-kappa B Proteins; Inflammation; Lipopolysaccharides; Losartan; Macrophages; Monocytes; Phosphorylation; PPAR gamma; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System; Signal Transduction | 2010 |
Regulation of the renin expression in the retinal pigment epithelium by systemic stimuli.
Topics: Administration, Oral; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood-Retinal Barrier; Calcium; Cells, Cultured; Enalapril; Epithelial Cells; Infusion Pumps, Implantable; Infusions, Subcutaneous; Kidney; Losartan; Mice; Renin; Renin-Angiotensin System; Retinal Pigment Epithelium; Time Factors; Water Deprivation | 2010 |
The impact of ANG II and IV on INS-1 cells and on blood glucose and plasma insulin.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Animals; Blood Glucose; Blotting, Western; Cell Line; Cystinyl Aminopeptidase; Gene Expression Regulation; Glucose; Insulin; Insulin Secretion; Losartan; Macrolides; Plasminogen Activator Inhibitor 1; Protein Binding; Rats; Receptor, Angiotensin, Type 1; RNA, Messenger; Transfection | 2010 |
Soluble uric acid increases intracellular calcium through an angiotensin II-dependent mechanism in immortalized human mesangial cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Calcium; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Humans; Losartan; Mesangial Cells; Polymerase Chain Reaction; Uric Acid | 2010 |
The effect of the expression of angiotensin II on extracellular matrix metalloproteinase inducer (EMMPRIN) in macrophages is mediated via the AT1/COX-2/PGE2 pathway.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Basigin; Cell Line; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Imidazoles; Losartan; Macrophages; Nitrobenzenes; Pyridines; Receptor, Angiotensin, Type 1; Signal Transduction; Sulfonamides | 2010 |
Interaction between vasopressin and angiotensin II in vivo and in vitro: effect on aquaporins and urine concentration.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antidiuretic Agents; Aquaporins; Deamino Arginine Vasopressin; Kidney Concentrating Ability; Kidney Tubules, Collecting; Losartan; Male; Models, Animal; Osmolar Concentration; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Signal Transduction; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase; Sodium, Dietary; Solute Carrier Family 12, Member 1; Vasopressins | 2010 |
Mechanical stress-evoked but angiotensin II-independent activation of angiotensin II type 1 receptor induces cardiac hypertrophy through calcineurin pathway.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Calcineurin; Calcineurin Inhibitors; Cardiomegaly; Chlorocebus aethiops; COS Cells; Losartan; Mice; Mice, Mutant Strains; Receptor, Angiotensin, Type 1; Stress, Mechanical; Tacrolimus | 2010 |
Angiotensin AT1 receptor activation mediates high glucose-induced epithelial-mesenchymal transition in renal proximal tubular cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Cadherins; Cell Line; Epithelial Cells; Epithelial-Mesenchymal Transition; Extracellular Matrix; Fibronectins; Glucose; Hyperglycemia; Kidney; Kidney Tubules, Proximal; Losartan; Peptidyl-Dipeptidase A; Rats; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; RNA, Messenger; Transforming Growth Factor beta1 | 2010 |
Angiotensin-(1-9), the product of angiotensin I conversion in platelets, enhances arterial thrombosis in rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arteries; Blood Platelets; Humans; Losartan; Male; Partial Thromboplastin Time; Peptide Fragments; Platelet Aggregation; Prothrombin Time; Rats; Rats, Wistar; Thrombosis | 2010 |
An efficient synthesis of a rationally designed 1,5 disubstituted imidazole AT(1) angiotensin II receptor antagonist: reorientation of imidazole pharmacophore groups in losartan reserves high receptor affinity and confirms docking studies.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Drug Design; Humans; Hypertension; Imidazoles; Losartan; Receptors, Angiotensin; Receptors, Drug; Structure-Activity Relationship | 2010 |
Angiotensin-(1-7) and low-dose angiotensin II infusion reverse salt-induced endothelial dysfunction via different mechanisms in rat middle cerebral arteries.
Topics: Acetylcholine; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cerebral Arterial Diseases; Cerebral Arteries; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Imidazoles; Infusions, Intravenous; Losartan; Male; Nitroprusside; Peptide Fragments; Pyridines; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Superoxides; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2010 |
Despite similar reduction of blood pressure and renal ANG II and ET-1 levels aliskiren but not losartan normalizes albuminuria in hypertensive Ren-2 rats.
Topics: Albuminuria; Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Down-Regulation; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Fumarates; Hypertension; Kidney; Losartan; Male; Mice; Pilot Projects; Radioimmunoassay; Rats; Rats, Transgenic; Renin; Time Factors | 2010 |
Acute hyperglycemia rapidly stimulates VEGF mRNA translation in the kidney. Role of angiotensin type 2 receptor (AT2).
Topics: Angiotensin II; Animals; Female; Gene Expression Regulation; Heterogeneous-Nuclear Ribonucleoprotein K; Hyperglycemia; Imidazoles; Kidney; Kidney Cortex; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyridines; Receptor, Angiotensin, Type 2; RNA, Messenger; Signal Transduction; Time Factors; Vascular Endothelial Growth Factor A | 2010 |
Persistent antihypertensive effect of aliskiren is accompanied by reduced proteinuria and normalization of glomerular area in Ren-2 transgenic rats.
Topics: Amides; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Disease Models, Animal; Fumarates; Heart Rate; Hypertension; Kidney Glomerulus; Losartan; Male; Proteinuria; Rats; Rats, Transgenic; Renin; Time Factors | 2010 |
Angiotensin II enhances connecting tubule glomerular feedback.
Topics: Amiloride; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Arterioles; Dose-Response Relationship, Drug; Epithelial Sodium Channel Blockers; Epithelial Sodium Channels; Feedback, Physiological; Glomerular Filtration Rate; Imidazoles; Kidney Glomerulus; Kidney Tubules; Losartan; Microcirculation; Pyridines; Rabbits; Receptor, Angiotensin, Type 2; Sodium Channel Blockers; Sodium Chloride; Vasoconstrictor Agents; Vasodilation | 2010 |
Moment-to-moment characteristics of the relationship between arterial pressure and renal interstitial hydrostatic pressure.
Topics: Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Autonomic Nervous System; Blood Pressure; Ganglionic Blockers; Hemodynamics; Hexamethonium; Hydrostatic Pressure; Kidney; Losartan; Male; Natriuresis; Rats; Rats, Wistar; Renal Circulation; Renin-Angiotensin System; Time Factors; Vasoconstrictor Agents | 2010 |
Salt-induced cardiac hypertrophy and interstitial fibrosis are due to a blood pressure-independent mechanism in Wistar rats.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Collagen Type I; Collagen Type III; Disease Models, Animal; Drinking; Eating; Echocardiography; Fibrosis; Gene Expression; Heart Ventricles; Hydralazine; Hypertension; Losartan; Male; Myocardium; Potassium; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin; Renin-Angiotensin System; Sodium; Sodium Chloride, Dietary; Transforming Growth Factor beta; Urine | 2010 |
AT₁ receptor and NAD(P)H oxidase mediate angiotensin II-stimulated antioxidant enzymes and mitogen-activated protein kinase activity in the rat hypothalamus.
Topics: Acetophenones; Angiotensin II; Animals; Antioxidants; Benzophenanthridines; Catalase; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Glutathione Peroxidase; Hypothalamus; Imidazoles; Injections, Intraventricular; Losartan; Male; NADPH Oxidases; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Sodium; Superoxide Dismutase; Water | 2010 |
High glucose upregulates upstream stimulatory factor 2 in human renal proximal tubular cells through angiotensin II-dependent activation of CREB.
Topics: Angiotensin II; Cell Line; Cyclic AMP Response Element-Binding Protein; Diabetic Nephropathies; Glucose; Humans; Kidney Tubules, Proximal; Losartan; Peptidyl-Dipeptidase A; Renin; Renin-Angiotensin System; Up-Regulation; Upstream Stimulatory Factors | 2011 |
Losartan attenuates vascular remodeling of the aorta in spontaneously hypertensive rats and the underlying mechanism.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta; Catalase; Hydrogen Peroxide; Hypertension; Losartan; Male; NADPH Oxidases; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2010 |
Impaired flow-induced dilation of coronary arterioles of dogs fed a low-salt diet: roles of ANG II, PKC, and NAD(P)H oxidase.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arterioles; Blood Pressure; Coronary Vessels; Dogs; Endothelium, Vascular; Losartan; Male; Models, Animal; NADPH Oxidases; Nitric Oxide; Protein Kinase C; Receptor, Angiotensin, Type 1; Sodium Chloride, Dietary; Superoxides; Vasodilation | 2010 |
CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent.
Topics: Amidines; Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Blotting, Western; Cells, Cultured; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Hydroxyeicosatetraenoic Acids; Hypertension; Lentivirus; Lisinopril; Losartan; Mass Spectrometry; Oligonucleotide Array Sequence Analysis; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; Time Factors | 2010 |
Hypothalamic SOCS-3 expression and the effect of intracerebroventricular angiotensin II injection on water intake and renal sodium handling in SHR.
Topics: Angiotensin II; Animals; Drinking; Hypothalamus; Injections, Intraventricular; Janus Kinase 2; Kidney; Losartan; Male; Oligonucleotides, Antisense; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins | 2010 |
Immobilization stress induces endothelial dysfunction by oxidative stress via the activation of the angiotensin II/its type I receptor pathway.
Topics: Acetylcholine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Arteries; Atherosclerosis; Immobilization; Losartan; Male; Nitric Oxide Synthase Type III; Oxidative Stress; Ramipril; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin | 2010 |
Impaired relaxation of cerebral arteries in the absence of elevated salt intake in normotensive congenic rats carrying the Dahl salt-sensitive renin gene.
Topics: Acetylcholine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Congenic; Antioxidants; Blood Pressure; Captopril; Crosses, Genetic; Cyclic N-Oxides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Infusions, Intravenous; Losartan; Male; Middle Cerebral Artery; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred BN; Rats, Inbred Dahl; Renin; Renin-Angiotensin System; Sodium Chloride, Dietary; Spin Labels; Superoxides; Vasodilation; Vasodilator Agents | 2010 |
Role of the organum vasculosum of the lamina terminalis for the chronic cardiovascular effects produced by endogenous and exogenous ANG II in conscious rats.
Topics: Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Heart Rate; Hypertension; Hypotension; Hypothalamus; Losartan; Male; Rats; Rats, Sprague-Dawley; Telemetry | 2010 |
Effects of angiotensin III on protein, DNA, and collagen synthesis of neonatal cardiomyocytes and cardiac fibroblasts in vitro.
Topics: Angiotensin II; Angiotensin III; Animals; Animals, Newborn; Captopril; Cell Proliferation; Cells, Cultured; Collagen; DNA; Fibroblasts; Heart; Losartan; Male; Methionine; Myocardium; Myocytes, Cardiac; Rats; Rats, Wistar; Sulfonic Acids | 2010 |
Similar renoprotection after renin-angiotensin-dependent and -independent antihypertensive therapy in 5/6-nephrectomized Ren-2 transgenic rats: are there blood pressure-independent effects?
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Creatinine; Diabetic Nephropathies; Diuretics; Drug Therapy, Combination; Furosemide; Hydrochlorothiazide; Hypertension; Indoles; Kidney Failure, Chronic; Labetalol; Losartan; Proteinuria; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Renin; Renin-Angiotensin System | 2010 |
Involvement of the AT1 receptor in the venoconstriction induced by angiotensin II in both the inferior vena cava and femoral vein.
Topics: Angiotensin II; Animals; Femoral Vein; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Pyridines; Rats; Receptor, Angiotensin, Type 1; Vasoconstriction; Vena Cava, Inferior | 2011 |
Co-operative effects of angiotensin II and caerulein in NFκB activation in pancreatic acinar cells in vitro.
Topics: alpha-Amylases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Cell Line; Ceruletide; Enzyme Activation; Imidazoles; Losartan; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Pancreas, Exocrine; Pancreatitis; Pyridines; Rats; Receptor, Angiotensin, Type 1 | 2011 |
Mechanisms related to NO-induced motility in differentiated rat aortic smooth muscle cells.
Topics: Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Aorta, Thoracic; Cell Movement; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Imidazoles; Insulin; Losartan; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Phosphatidylinositol 3-Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Up-Regulation | 2011 |
Chronic infusion of angiotensin receptor antagonists in the hypothalamic paraventricular nucleus prevents hypertension in a rat model of sleep apnea.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Disease Models, Animal; Hypertension; Imidazoles; Losartan; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Pyridines; Rats; Rats, Sprague-Dawley; Sleep Apnea Syndromes | 2011 |
Endogenous angiotensin II suppresses stretch-induced ANP secretion via AT1 receptor pathway.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atrial Natriuretic Factor; Blood Pressure; Cardiomyopathy, Hypertrophic; Extracellular Fluid; Gene Expression; Heart Atria; Hypertension, Renal; Imidazoles; Losartan; Male; Myocardial Contraction; Peptide Fragments; Perfusion; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Reflex, Stretch | 2011 |
Enhanced angiotensin II-mediated central sympathoexcitation in streptozotocin-induced diabetes: role of superoxide anion.
Topics: Adenoviridae; Angiotensin II; Animals; Blood Pressure; Diabetes Mellitus, Experimental; Gene Expression; Heart Rate; Kidney; Losartan; Male; NADPH Oxidases; Paraventricular Hypothalamic Nucleus; Phosphoproteins; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Superoxide Dismutase; Superoxides; Sympathetic Nervous System; Transduction, Genetic | 2011 |
Supramolecular interactions between losartan and hydroxypropyl-β-CD: ESI mass-spectrometry, NMR techniques, phase solubility, isothermal titration calorimetry and anti-hypertensive studies.
Topics: Administration, Oral; alpha-Cyclodextrins; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Calorimetry; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Carriers; Drug Compounding; Hypertension; Kinetics; Losartan; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Wistar; Solubility; Spectrometry, Mass, Electrospray Ionization; Technology, Pharmaceutical | 2011 |
Atrial fibrillation induces myocardial fibrosis through angiotensin II type 1 receptor-specific Arkadia-mediated downregulation of Smad7.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Atrial Fibrillation; Cells, Cultured; Collagen; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibrosis; Losartan; Models, Animal; Myocardium; Rabbits; Receptor, Angiotensin, Type 1; RNA, Small Interfering; Smad7 Protein; Transforming Growth Factor beta1; Ubiquitin-Protein Ligases | 2011 |
Blockade of the renin-angiotensin system ameliorates apelin production in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adipokines; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Apelin; Captopril; Cells, Cultured; Imidazoles; Intercellular Signaling Peptides and Proteins; Lipid Metabolism; Losartan; Mice; Perindopril; Pyridines; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin; Renin-Angiotensin System; RNA, Messenger | 2011 |
[Regulation of the transcription of oxidized low-density-lipoprotein receptor by angiotensin II].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Cells, Cultured; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Losartan; Receptors, Angiotensin; RNA, Messenger; Scavenger Receptors, Class E | 2001 |
Glucocorticoid-induced fetal programming alters the functional complement of angiotensin receptor subtypes within the kidney.
Topics: Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Betamethasone; Blood Pressure; Female; Fetal Development; Glucocorticoids; Kidney; Losartan; Nitric Oxide; Pregnancy; Prenatal Exposure Delayed Effects; Reactive Oxygen Species; Receptors, Angiotensin; Sheep | 2011 |
Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Atherosclerosis; Bone Marrow Cells; Bone Marrow Transplantation; Cell Adhesion; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; Cytokines; Dietary Fats; Disease Models, Animal; Endothelial Cells; Humans; Inflammation Mediators; Losartan; Macrophages; Male; Mice; Mice, Knockout; Monocytes; Peptide Fragments; Peptidyl-Dipeptidase A; Receptors, LDL | 2011 |
Angiotensin II induces the expression of c-reactive protein via MAPK-dependent signal pathway in U937 macrophages.
Topics: Acetylcysteine; Angiotensin II; Antihypertensive Agents; C-Reactive Protein; Flavonoids; Humans; Imidazoles; Losartan; Macrophages; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proline; Pyridines; Thiocarbamates; U937 Cells | 2011 |
Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-β1 pathways in cardiac fibroblasts.
Topics: Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Adhesion Molecules; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; Fibroblasts; Fibrosis; Guanine Nucleotide Exchange Factors; Infusions, Subcutaneous; Losartan; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; ras Proteins; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Messenger; Signal Transduction; Smad2 Protein; Smad3 Protein; Time Factors; Transfection; Transforming Growth Factor beta1; Up-Regulation | 2011 |
Combination treatment of angiotensin II type I receptor blocker and new oral iron chelator attenuates progression of nonalcoholic steatohepatitis in rats.
Topics: Administration, Oral; Angiogenesis Inhibitors; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzoates; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cultured; Choline Deficiency; Deferasirox; Disease Progression; Drug Therapy, Combination; Fatty Liver; Hepatic Stellate Cells; Iron Chelating Agents; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Losartan; Male; Neovascularization, Pathologic; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Rats; Rats, Inbred F344; Time Factors; Transforming Growth Factor beta1; Triazoles | 2011 |
Inhibition of NF-κB-induced inflammatory responses by angiotensin II antagonists in aged rat kidney.
Topics: Aging; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Enalapril; Gene Expression; Kidney; Losartan; Male; MAP Kinase Signaling System; Nephritis; NF-kappa B; Oxidative Stress; Phosphorylation; Random Allocation; Rats; Rats, Inbred BN; Rats, Inbred F344; Transcription Factor RelA | 2011 |
Chronic angiotensin II infusion modulates angiotensin II type I receptor expression in the subfornical organ and the rostral ventrolateral medulla in hypertensive rats.
Topics: Angiotensin II; Animals; Blood Pressure; Gene Expression Regulation; Hypertension; Losartan; Male; Medulla Oblongata; Rats; Rats, Inbred SHR; Rats, Wistar; Receptor, Angiotensin, Type 1; RNA, Messenger; Subfornical Organ; Sympathetic Nervous System | 2011 |
Hemin decreases cardiac oxidative stress and fibrosis in a rat model of systemic hypertension via PI3K/Akt signalling.
Topics: Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Antihypertensive Agents; Antioxidants; Apoptosis; Cardiomyopathies; Caspase 3; Cells, Cultured; Collagen Type I; Disease Models, Animal; Enzyme Activation; Fibrosis; Heme Oxygenase (Decyclizing); Hemin; Hemodynamics; Hypertension, Renovascular; Losartan; Male; Myocytes, Cardiac; NADPH Oxidases; Oxidative Stress; Oxidoreductases Acting on CH-CH Group Donors; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; rac1 GTP-Binding Protein; Rats; Rats, Wistar; rhoA GTP-Binding Protein; Signal Transduction; Time Factors; Ventricular Function, Left | 2011 |
Angiotensin-II induced nitric oxide production during buffalo sperm capacitation and acrosome reaction.
Topics: Acrosome Reaction; Angiotensin II; Animals; Buffaloes; Dose-Response Relationship, Drug; Losartan; Male; Nitric Oxide; Sperm Capacitation; Spermatozoa | 2012 |
Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Aortic Aneurysm; Aortic Rupture; Disease Models, Animal; Disease Progression; Enalapril; Losartan; MAP Kinase Signaling System; Marfan Syndrome; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Receptor, Angiotensin, Type 2; Signal Transduction; Transforming Growth Factor beta | 2011 |
Altered regulation of the rostral ventrolateral medulla in hypertensive obese Zucker rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Brain Stem; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Heart Rate; Hypertension; Losartan; Medulla Oblongata; Microinjections; Muscle Tonus; Muscle, Smooth, Vascular; Obesity; Rats; Rats, Zucker; Receptors, GABA-A; Splanchnic Circulation; Sympathetic Nervous System | 2011 |
NADPH oxidase-dependent formation of reactive oxygen species contributes to angiotensin II-induced epithelial-mesenchymal transition in rat peritoneal mesothelial cells.
Topics: Actins; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blotting, Western; Cadherins; Cell Dedifferentiation; Cells, Cultured; Culture Media, Serum-Free; Down-Regulation; Epithelial Cells; Epithelial-Mesenchymal Transition; Extracellular Matrix; Losartan; Male; Microscopy, Confocal; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; Onium Compounds; Peritoneal Fibrosis; Plasminogen Activator Inhibitor 1; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 2011 |
Fetal uninephrectomy in male sheep alters the systemic and renal responses to angiotensin II infusion and AT1R blockade.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Female; Heart Rate; Kidney; Losartan; Male; Nephrectomy; Pregnancy; Renin-Angiotensin System; Sheep; Up-Regulation | 2011 |
Down-regulation of DDAH2 and eNOS induces endothelial dysfunction in sinoaortic-denervated rats.
Topics: Amidohydrolases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Apoptosis; Denervation; Down-Regulation; Endothelial Cells; Gene Expression Regulation, Enzymologic; Hemodynamics; Losartan; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type III; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Vasodilation | 2011 |
Evidence of an intracellular angiotensin-generating system and non-AT1, non-AT2 binding site in a human pancreatic cell line.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Binding Sites; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Humans; Intracellular Space; Losartan; Pancreatic Neoplasms; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Vascular Endothelial Growth Factor A | 2011 |
Intracellular angiotensin II activates rat myometrium.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Arsenicals; Autophagy; Brefeldin A; Calcium Signaling; Carbolines; Cells, Cultured; Egtazic Acid; Endocytosis; Endoplasmic Reticulum; Endosomes; Enzyme Inhibitors; Estrenes; Female; Heparin; Imidazoles; Inositol 1,4,5-Trisphosphate Receptors; Losartan; Lysosomes; Macrocyclic Compounds; Macrolides; Models, Biological; Myometrium; NADP; Oxazoles; Piperazines; Pyridines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Ryanodine; Saralasin; Signal Transduction; Sirolimus; Type C Phospholipases; Uterus | 2011 |
Both AT₁ and AT₂ receptors mediate proliferation and migration of porcine vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Coronary Vessels; Dose-Response Relationship, Drug; Focal Adhesion Protein-Tyrosine Kinases; Imidazoles; Losartan; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein Kinase Inhibitors; Pyridines; Quinolones; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sulfones; Swine; Time Factors | 2011 |
Effects of losartan, in monotherapy or in association with hydrochlorothiazide, in chronic nephropathy resulting from losartan treatment during lactation.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Blood Pressure; Chronic Disease; Disease Models, Animal; Diuretics; Drug Therapy, Combination; Female; Hydrochlorothiazide; Kidney; Kidney Diseases; Lactation; Losartan; Male; Nephrons; Rats; Rats, Inbred Strains | 2011 |
Caveolae are essential for angiotensin II type 1 receptor-mediated ANP secretion.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Atrial Natriuretic Factor; beta-Cyclodextrins; Blood Pressure; Catheterization; Caveolae; Chromatography, High Pressure Liquid; Heart Atria; Infusion Pumps; Losartan; Male; Myocardial Contraction; Myocardium; Organ Culture Techniques; Perfusion; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1 | 2011 |
Phosphoproteomic analysis of AT1 receptor-mediated signaling responses in proximal tubules of angiotensin II-induced hypertensive rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cells, Cultured; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Genes; Glycogen Synthase Kinase 3; Hypertension; Kidney Tubules, Proximal; Losartan; Male; MAP Kinase Signaling System; Mice; Phosphoproteins; Phosphorylation; Protein Kinase C-alpha; Proteomics; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Signal Transduction; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers | 2011 |
Angiotensin II does not directly affect Aβ secretion or β-/γ-secretase activity via activation of angiotensin II type 1 receptor.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Cells, Cultured; Hippocampus; Humans; Losartan; Neurons; Peptide Fragments; Presenilin-1; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Transfection | 2011 |
Proinflammatory role of angiotensin II in a rat nephrosis model induced by adriamycin.
Topics: Angiotensin II; Animals; Cholesterol; Disease Models, Animal; Doxorubicin; Endothelin-1; Fluorescent Antibody Technique; Inflammation; Inflammation Mediators; Kidney; Losartan; Male; Nephrosis; Proteinuria; Rats; Rats, Sprague-Dawley; Time Factors; Triglycerides; Weight Gain | 2011 |
Impact of systemically active neurohumoral factors on the erectile response of the rat.
Topics: Angiotensin II; Animals; Blood Pressure; Hexamethonium; Losartan; Male; Methoxamine; Neurotransmitter Agents; Penile Erection; Rats; Rats, Sprague-Dawley; Terbutaline | 2011 |
Intracrine action of angiotensin II in the intact ventricle of the failing heart: angiotensin II changes cardiac excitability from within.
Topics: Action Potentials; Angiotensin II; Animals; Cell Separation; Cricetinae; Heart Failure; Heart Ventricles; In Vitro Techniques; Intracellular Space; Losartan; Male; Myocytes, Cardiac; Signal Transduction | 2011 |
Angiotensin III stimulates ERK1/2 mitogen-activated protein kinases and astrocyte growth in cultured rat astrocytes.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin III; Animals; Astrocytes; Brain Stem; Cells, Cultured; Cerebellum; Enzyme Inhibitors; Flavonoids; Imidazoles; Losartan; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley | 2011 |
Des-aspartate-angiotensin-I and angiotensin IV improve glucose tolerance and insulin signalling in diet-induced hyperglycaemic mice.
Topics: Angiotensin I; Angiotensin II; Animals; Blood Glucose; Cystinyl Aminopeptidase; Dietary Fats; Dietary Sucrose; Drug Administration Schedule; Glucose Intolerance; Hyperglycemia; Indomethacin; Insulin; Insulin Receptor Substrate Proteins; Janus Kinase 2; Losartan; Male; Mice; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases; Receptor, Angiotensin, Type 1; Signal Transduction | 2011 |
Brain AT1 receptor activates the sympathetic nervous system through toll-like receptor 4 in mice with heart failure.
Topics: Angiotensin II; Animals; Body Weight; Brain; Brain Stem; Electrocardiography; Heart; Heart Failure; Infusions, Intraventricular; Losartan; Male; Mice; Mice, Inbred ICR; Models, Biological; Myeloid Differentiation Factor 88; Myocardial Infarction; NF-kappa B; Norepinephrine; Organ Size; Receptor, Angiotensin, Type 1; Sympathetic Nervous System; Toll-Like Receptor 4; Ventricular Dysfunction, Left | 2011 |
Decreased nNOS in the PVN leads to increased sympathoexcitation in chronic heart failure: role for CAPON and Ang II.
Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Line, Tumor; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Heart Failure; Hemodynamics; Immunohistochemistry; Kidney; Losartan; Male; Microinjections; Nitric Oxide Synthase Type I; omega-N-Methylarginine; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, N-Methyl-D-Aspartate; RNA Interference; RNA, Messenger; Sympathetic Nervous System; Time Factors | 2011 |
Role of perivascular adipose tissue-derived methyl palmitate in vascular tone regulation and pathogenesis of hypertension.
Topics: 4-Aminopyridine; Adipocytes; Adipose Tissue; Angiotensin II; Animals; Aorta; Calcium; Cells, Cultured; Endothelium, Vascular; Fibroblasts; Glyburide; Hypertension; Losartan; Male; Palmitates; Peptides; Potassium Channels, Voltage-Gated; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetraethylammonium; Vasodilation; Vasodilator Agents | 2011 |
Impaired vascular contractility and aortic wall degeneration in fibulin-4 deficient mice: effect of angiotensin II type 1 (AT1) receptor blockade.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Aorta, Thoracic; Aortic Aneurysm; Extracellular Matrix Proteins; Female; Humans; Immunohistochemistry; In Vitro Techniques; Losartan; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Phenylephrine; Pregnancy; Receptor, Angiotensin, Type 1; Smad2 Protein; Transcriptome; Transforming Growth Factor beta; Vasoconstriction; Vasoconstrictor Agents | 2011 |
Importance of central AT₁ receptors for sodium intake induced by GABAergic activation of the lateral parabrachial nucleus.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Drinking; GABA-A Receptor Agonists; Injections, Intraventricular; Losartan; Male; Microinjections; Muscimol; Pons; Rats; Rats, Sprague-Dawley; Saline Solution, Hypertonic | 2011 |
Blood pressure and renal hemodynamic responses to acute angiotensin II infusion are enhanced in a female mouse model of systemic lupus erythematosus.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Female; Hypertension; Infusions, Intra-Arterial; Kidney; Losartan; Lupus Erythematosus, Systemic; Mice; Mice, Inbred NZB; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renal Circulation; RNA, Messenger; Vascular Resistance; Vasoconstriction | 2011 |
Increased oxidative stress, the renin-angiotensin system, and sympathetic overactivation induce hypertension in kidney androgen-regulated protein transgenic mice.
Topics: Angiotensin II; Animals; Blood Pressure; Captopril; Cyclic N-Oxides; Hypertension; Kidney; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Norepinephrine; Oxidative Stress; Proteins; Renin-Angiotensin System; Spin Labels; Sympathetic Nervous System; Transgenes | 2011 |
Losartan improves aortic endothelium-dependent relaxation via proline-rich tyrosine kinase 2/Src/Akt pathway in type 2 diabetic Goto-Kakizaki rats.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blotting, Western; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Focal Adhesion Kinase 2; Immunohistochemistry; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Losartan; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinase; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction; src-Family Kinases; Vasodilation; Vasodilator Agents | 2011 |
Angiotensin II type 1 receptor, but no type 2 receptor, interferes with the insulin-induced nitric oxide production in HUVECs.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Cells, Cultured; Enzyme Activation; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Insulin; Insulin Receptor Substrate Proteins; JNK Mitogen-Activated Protein Kinases; Losartan; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Serine; Signal Transduction; Tyrosine | 2011 |
ETA and ETB receptors are expressed in vascular adventitial fibroblasts.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Blotting, Western; Cells, Cultured; Collagen Type I; Connective Tissue; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Losartan; Mice; Oligopeptides; Peptides, Cyclic; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; Time Factors; Viper Venoms | 2011 |
Mast cells are required for the development of renal fibrosis in the rodent unilateral ureteral obstruction model.
Topics: Angiotensin II; Animals; Cell Degranulation; Fibrosis; Humans; In Vitro Techniques; Kidney; Kidney Diseases; Losartan; Male; Mast Cells; Mice; Rats; Renin; Renin-Angiotensin System; Ureteral Obstruction | 2012 |
Gαq-protein carboxyl terminus imitation polypeptide GCIP-27 attenuates proliferation of vascular smooth muscle cells and vascular remodeling in spontaneously hypertensive rats.
Topics: 3T3 Cells; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Pressure; Blood Pressure Determination; Calcium; Cardiotonic Agents; Cell Culture Techniques; Cell Proliferation; Collagen; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; GTP-Binding Protein alpha Subunits, Gq-G11; Hypertension; Hypertrophy; Losartan; Male; Mice; Molecular Targeted Therapy; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Peptides; Random Allocation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Tetrazolium Salts; Thiazoles; Type C Phospholipases; Vasoconstrictor Agents | 2011 |
Angiotensin II induces nephrin dephosphorylation and podocyte injury: role of caveolin-1.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Benzimidazoles; Blotting, Western; Caveolae; Caveolin 1; CSK Tyrosine-Protein Kinase; Immunoprecipitation; Losartan; Membrane Proteins; Mice; Phosphorylation; Plasmids; Podocytes; Protein-Tyrosine Kinases; Proteinuria; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Signal Transduction; src-Family Kinases; Transfection | 2012 |
Plasma and tissue concentrations of proangiotensin-12 in rats treated with inhibitors of the renin-angiotensin system.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Blood Pressure; Body Weight; Imidazolidines; Kidney; Losartan; Male; Myocardium; Organ Size; Peptide Fragments; Radioimmunoassay; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin; Renin-Angiotensin System | 2012 |
(Pro)renin receptor: another member of the system controlled by angiotensin II?
Topics: Angiotensin II; Cell Line; Cell Survival; Cells, Cultured; Fibronectins; Gene Silencing; Glucose; Humans; Losartan; Mesangial Cells; Receptor, Angiotensin, Type 1; Receptors, Cell Surface; Renin-Angiotensin System; RNA, Messenger; Time Factors; Trypan Blue; Vacuolar Proton-Translocating ATPases | 2012 |
Comparative effects of different modes of renin angiotensin system inhibition on hypercholesterolaemia-induced atherosclerosis.
Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Atherosclerosis; Blood Pressure; Cholesterol; Diet, High-Fat; Enalapril; Fumarates; Hypercholesterolemia; Kidney; Losartan; Male; Mice; Mice, Knockout; Receptor, Angiotensin, Type 1; Receptors, LDL; Renin; Renin-Angiotensin System | 2012 |
Physiological regulation of MMPs and tPA/PAI in the arterial wall of rats by noradrenergic tone and angiotensin II.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Blood Pressure; Densitometry; Femoral Artery; Gelatin; Gene Expression Regulation; Guanethidine; Losartan; Male; Matrix Metalloproteinases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Norepinephrine; Plasminogen Activator Inhibitor 1; Rats; Rats, Inbred WKY; Real-Time Polymerase Chain Reaction; RNA, Messenger; Tissue Plasminogen Activator | 2012 |
Regulation of peroxisome proliferator-activated receptor-γ by angiotensin II via transforming growth factor-β1-activated p38 mitogen-activated protein kinase in aortic smooth muscle cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Cells, Cultured; Enzyme Inhibitors; Histone Deacetylases; Imidazoles; Losartan; Male; Mice; Mice, Inbred C57BL; Models, Animal; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; PPAR gamma; Pyridines; Receptor, Angiotensin, Type 1; RNA, Messenger; RNA, Small Interfering; Transforming Growth Factor beta1 | 2012 |
Cardiovascular actions of angiotensin-(1-12) in the hypothalamic paraventricular nucleus of the rat are mediated via angiotensin II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Angiotensins; Animals; Blood Pressure; Cardiovascular System; Chymases; Heart Rate; Imidazoles; Kidney; Losartan; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin; Sympathetic Nervous System; Vagotomy; Vagus Nerve | 2012 |
Losartan inhibits STAT1 activation and protects human glomerular mesangial cells from angiotensin II induced premature senescence.
Topics: Acetylcysteine; Angiotensin II; beta-Galactosidase; Cell Cycle Checkpoints; Cell Line; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; Gene Knockdown Techniques; Humans; Losartan; Mesangial Cells; Reactive Oxygen Species; Signal Transduction; STAT1 Transcription Factor; Tumor Suppressor Protein p53 | 2012 |
Angiotensin II induces tumor necrosis factor-α expression and release from cultured human podocytes.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Cell Proliferation; Cells, Cultured; Gene Expression; Humans; Imidazoles; Losartan; Podocytes; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Tumor Necrosis Factor-alpha | 2012 |
Angiotensin AT1 receptor blockers suppress oxidized low-density lipoprotein-derived formation of foam cells.
Topics: Acetyl-CoA C-Acetyltransferase; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Cells, Cultured; Cholesterol Esters; Enzyme Inhibitors; ErbB Receptors; Foam Cells; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Lipoproteins, LDL; Losartan; Macrophages; Quinazolines; Tetrazoles; Triglycerides; Tyrphostins | 2012 |
The effect of losartan and carvedilol on renal haemodynamics and altered metabolism in fructose-fed Sprague-Dawley rats.
Topics: Angiotensin II; Animals; Body Weight; Carbazoles; Carvedilol; Fructose; Glucose Tolerance Test; Hemodynamics; Insulin Resistance; Kidney; Losartan; Male; Norepinephrine; Phenylephrine; Propanolamines; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents | 2012 |
Role of angiotensin II-mediated AMPK inactivation on obesity-related salt-sensitive hypertension.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Diet, High-Fat; Disease Models, Animal; Hypertension; Kidney; Losartan; Metabolic Syndrome; Metformin; Mice; Mice, Inbred C57BL; Obesity; Phosphorylation; Sodium; Sodium, Dietary | 2012 |
Aspirin suppresses cardiac fibroblast proliferation and collagen formation through downregulation of angiotensin type 1 receptor transcription.
Topics: Angiotensin II; Animals; Aspirin; Cell Proliferation; Collagen; Down-Regulation; Fibroblasts; Losartan; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; NADPH Oxidases; NF-kappa B; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Transcription, Genetic | 2012 |
Decreased anandamide transporter activity and calcitonin gene-related peptide production in spontaneously hypertensive rats: role of angiotensin II.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Arachidonic Acids; Blood Pressure; Calcitonin Gene-Related Peptide; Endocannabinoids; Ganglia, Spinal; Hypertension; Losartan; Lymphocytes; Male; Membrane Transport Proteins; Polyunsaturated Alkamides; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; RNA, Messenger; Up-Regulation | 2012 |
Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome.
Topics: Acetophenones; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arteries; Blood Pressure; Cardiomegaly; Constriction, Pathologic; Disease Models, Animal; Elastin; Enzyme Activation; Enzyme Inhibitors; Humans; Hypertension; Losartan; Mice; NADPH Oxidases; Oxidative Stress; Sequence Deletion; Williams Syndrome | 2012 |
Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice.
Topics: 3T3-L1 Cells; Adipocytes; Adiposity; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Blood Pressure; Diet, High-Fat; Disease Models, Animal; Estrogens; Female; Gene Expression Regulation, Enzymologic; Hypertension; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity; Ovariectomy; Peptide Fragments; Peptidyl-Dipeptidase A; Progesterone; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptors, G-Protein-Coupled; Risk Factors; RNA, Messenger; Sex Factors; Testosterone; Time Factors; Weight Gain | 2012 |
Angiotensin II type 2 receptor-dependent increase in nitric oxide synthase activity in the endothelium of db/db mice is mediated via a MEK pathway.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Flavonoids; Losartan; Male; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Kinase Kinases; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; Oligopeptides; Phosphorylation; Protein Kinase Inhibitors; Receptor, Angiotensin, Type 2; Signal Transduction; Time Factors; Vasodilation; Vasodilator Agents | 2012 |
Angiotensin II induces protein overexpression of hyperpolarization-activated cyclic nucleotide-gated channels in primary cultured nodose neurons.
Topics: Action Potentials; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cells, Cultured; Cyclic N-Oxides; Cyclic Nucleotide-Gated Cation Channels; Losartan; Male; NADPH Oxidases; Neurons; Nodose Ganglion; Rats; Rats, Sprague-Dawley; Spin Labels; Superoxides | 2012 |
Aldosterone does not require angiotensin II to activate NCC through a WNK4-SPAK-dependent pathway.
Topics: Adrenalectomy; Aldosterone; Amiloride; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Diuretics; Dose-Response Relationship, Drug; Hydrochlorothiazide; Kidney; Losartan; Models, Animal; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium Chloride Symporters | 2012 |
Losartan attenuates human monocyte-derived dendritic cell immune maturation via downregulation of lectin-like oxidized low-density lipoprotein receptor-1.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Antigens, CD; Carrier Proteins; CD36 Antigens; CD83 Antigen; Cell Proliferation; Cells, Cultured; Coculture Techniques; Dendritic Cells; Down-Regulation; HLA-DR Antigens; Humans; Immunoglobulins; Interferon-gamma; Interleukin-12; Lipoproteins, LDL; Losartan; Membrane Glycoproteins; Monocytes; Scavenger Receptors, Class E; Serine-Arginine Splicing Factors; T-Lymphocytes | 2012 |
Activation of thiazide-sensitive co-transport by angiotensin II in the cyp1a1-Ren2 hypertensive rat.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cytochrome P-450 CYP1A1; Hydrochlorothiazide; Hypertension; Kidney Tubules, Distal; Losartan; Male; Microvessels; Natriuresis; Rats; Rats, Transgenic; Renin; Sodium Chloride Symporters; Spironolactone | 2012 |
Aspirin downregulates angiotensin type 1 receptor transcription implications in capillary formation from endothelial cells.
Topics: Angiogenesis Inhibitors; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Aspirin; Capillaries; Cells, Cultured; Down-Regulation; Enzyme Inhibitors; Human Umbilical Vein Endothelial Cells; Humans; Losartan; Mitogen-Activated Protein Kinases; NADPH Oxidases; Neovascularization, Physiologic; Receptor, Angiotensin, Type 1; RNA, Messenger; Salicylic Acid; Transcription, Genetic; Vascular Endothelial Growth Factor A | 2012 |
Counteraction between angiotensin II and angiotensin-(1-7) via activating angiotensin type I and Mas receptor on rat renal mesangial cells.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blotting, Western; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Interactions; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Glomerular Mesangium; Imidazoles; Losartan; MAP Kinase Signaling System; Mesangial Cells; Microscopy, Confocal; Peptide Fragments; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pyridines; Rats; Real-Time Polymerase Chain Reaction; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Receptors, G-Protein-Coupled; Transforming Growth Factor beta1 | 2012 |
Resveratrol attenuates angiotensin II-induced senescence of vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; beta-Galactosidase; Blotting, Western; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Enzyme Assays; Imidazoles; Losartan; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Resveratrol; Stilbenes; Tumor Suppressor Protein p53 | 2012 |
Angiotensin-(3-4) counteracts the Angiotensin II inhibitory action on renal Ca2+-ATPase through a cAMP/PKA pathway.
Topics: Allosteric Regulation; Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Binding, Competitive; Calcium-Transporting ATPases; Cell Membrane; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Assays; HEK293 Cells; Humans; Imidazoles; Immunoprecipitation; Kidney Tubules, Proximal; Losartan; Oligopeptides; Phosphorylation; Protein Binding; Protein Conformation; Pyridines; Receptor, Angiotensin, Type 2; Sheep; Signal Transduction; Transfection | 2012 |
The role of AT1 receptor-mediated reproductive function in renovascular hypertension in male rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Corticosterone; Hypertension, Renovascular; Losartan; Male; Prolactin; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Sexual Behavior, Animal; Spermatogenesis; Testosterone | 2012 |
Characterization of Angiotensin-(1-7) effects on the cardiovascular system in an experimental model of type-1 diabetes.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Captopril; Cardiovascular System; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Endothelin-1; Hyperglycemia; Kidney; Losartan; Male; NADPH Oxidases; Peptide Fragments; Peptides; Peptidyl-Dipeptidase A; Prostaglandins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Reperfusion Injury | 2012 |
Involvement of enhanced cardiac sympathetic afferent reflex in sympathetic activation in early stage of diabetes.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Arrhythmia Agents; Bradykinin; Capsaicin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diterpenes; Heart; Kidney; Lidocaine; Losartan; Male; Norepinephrine; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Reflex; Sympathetic Nervous System; TRPV Cation Channels | 2012 |
Salt-induced downregulation of renal aquaporins is prevented by losartan.
Topics: Actins; Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Aquaporin 1; Aquaporin 2; Blood Pressure; Blotting, Western; Down-Regulation; Drinking Water; Immunohistochemistry; Kidney Cortex; Kidney Function Tests; Kidney Tubules; Losartan; Male; Natriuresis; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Sodium Chloride, Dietary; Transforming Growth Factor beta1 | 2012 |
AT1 receptors activation enhances the expression of MMP-2, MMP-13 and VEGF but not MMP-9 in B16F10 melanoma cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Cell Line, Tumor; Humans; Losartan; Matrix Metalloproteinase 13; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Melanoma; Mice; Receptor, Angiotensin, Type 1; Vascular Endothelial Growth Factor A | 2011 |
A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity.
Topics: Adipose Tissue; alpha-MSH; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Body Weight; Brain; Captopril; Corticotropin-Releasing Hormone; Eating; Gene Deletion; Leptin; Losartan; Male; Mice; Mice, Inbred C57BL; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Sympathetic Nervous System | 2012 |
Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Carotid Arteries; Cell Movement; Cell Proliferation; Cells, Cultured; Genes, Reporter; Hyperplasia; I-kappa B Kinase; Infusion Pumps, Implantable; Infusions, Subcutaneous; Interleukin-18; JNK Mitogen-Activated Protein Kinases; Losartan; Male; Matrix Metalloproteinase 9; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; Promoter Regions, Genetic; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; RNA Interference; Signal Transduction; Superoxides; Transcription Factor AP-1; Transcription Factor RelA; Transfection | 2012 |
Angiotensin-(1-12) in the rostral ventrolateral medullary pressor area of the rat elicits sympathoexcitatory responses.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Arterial Pressure; Captopril; Chymases; Imidazoles; Losartan; Male; Medulla Oblongata; Oligopeptides; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Peptidyl-Dipeptidase A; Phenylethanolamine N-Methyltransferase; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Sympathetic Nervous System | 2013 |
Exercise training normalizes enhanced sympathetic activation from the paraventricular nucleus in chronic heart failure: role of angiotensin II.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Heart Failure; Heart Rate; Kidney; Losartan; Neurons; Paraventricular Hypothalamic Nucleus; Physical Conditioning, Animal; Rats; Sympathetic Nervous System | 2012 |
Increased activity of the renin-angiotensin and sympathetic nervous systems is required for regulation of the blood pressure in rats fed a low-protein diet.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arterial Pressure; Diet, Protein-Restricted; Enalapril; Heart Rate; Losartan; Male; Prazosin; Rats; Rats, Inbred F344; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Sympathetic Nervous System | 2013 |
Angiotensin II increases CTGF expression via MAPKs/TGF-β1/TRAF6 pathway in atrial fibroblasts.
Topics: Angiotensin II; Animals; Connective Tissue Growth Factor; Fibroblasts; Fibrosis; Gene Expression; Heart Atria; Losartan; MAP Kinase Kinase 4; MAP Kinase Kinase Kinases; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Primary Cell Culture; Protein Kinase Inhibitors; Signal Transduction; TNF Receptor-Associated Factor 6; Transforming Growth Factor beta1 | 2012 |
A primary culture of distal convoluted tubules expressing functional thiazide-sensitive NaCl transport.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cells, Cultured; Female; Kidney Tubules, Distal; Losartan; Mice; Mice, Knockout; Sodium Chloride; Sodium Chloride Symporter Inhibitors; Sodium Chloride Symporters; Thiazides | 2012 |
Implication of multiple signaling pathways in the regulation of angiotensin II induced enhanced expression of Giα proteins in vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Bucladesine; Calcium; Cell Line; Chelating Agents; Dactinomycin; Drug Interactions; Egtazic Acid; Estrenes; Gallic Acid; Gene Expression Regulation; Genistein; GTP-Binding Protein alpha Subunits, Gi-Go; Imidazoles; Losartan; Nucleic Acid Synthesis Inhibitors; Protein Kinase Inhibitors; Pyridines; Pyrrolidinones; Rats; Signal Transduction; Type C Phospholipases | 2012 |
AT1 antagonism and renin inhibition in mice: pivotal role of targeting angiotensin II in chronic kidney disease.
Topics: Albuminuria; Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Dose-Response Relationship, Drug; Fumarates; Gene Expression; Kidney; Losartan; Male; Mice; Renal Insufficiency, Chronic; Renin; Renin-Angiotensin System; Treatment Outcome | 2012 |
Regulation of aortic extracellular matrix synthesis via noradrenergic system and angiotensin II in juvenile rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Collagen Type I; Collagen Type II; Collagen Type III; Elastin; Extracellular Matrix; Guanethidine; Losartan; Male; Rats; Rats, Inbred WKY; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sympathectomy; Sympathetic Nervous System | 2012 |
Similarities and differences between effects of angiotensin III and angiotensin II on human prostate cancer cell migration and proliferation.
Topics: Angiotensin II; Angiotensin III; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Imidazoles; Losartan; Male; Prostatic Neoplasms; Pyridines; Structure-Activity Relationship | 2012 |
Inhibition of PTEN expression and activity by angiotensin II induces proliferation and migration of vascular smooth muscle cells.
Topics: Adenoviridae; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Cell Movement; Cell Proliferation; Focal Adhesion Kinase 1; Gene Expression Regulation; Losartan; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats; Rosiglitazone; Signal Transduction; Sulfones; Thiazolidinediones; Tissue Culture Techniques; Transduction, Genetic; Vasodilator Agents | 2013 |
(Pro)renin receptor triggers distinct angiotensin II-independent extracellular matrix remodeling and deterioration of cardiac function.
Topics: Adenoviridae; Angiotensin II; Animals; Apoptosis; Cell Proliferation; Enzyme Activation; Extracellular Matrix; Fibrosis; Gene Transfer Techniques; Heart Function Tests; Heart Ventricles; HSP27 Heat-Shock Proteins; Kruppel-Like Transcription Factors; Losartan; Male; MAP Kinase Signaling System; Myocardium; Myocytes, Cardiac; Organ Specificity; Phosphorylation; Prorenin Receptor; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Up-Regulation; Wnt Signaling Pathway | 2012 |
Upregulation of junctional adhesion molecule-A is a putative prognostic marker of hypertension.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Arterial Pressure; Biomarkers; Blood Vessels; Case-Control Studies; Cell Adhesion Molecules; Cell Line; Disease Models, Animal; Humans; Hydralazine; Hypertension; Hypertension, Renovascular; Losartan; Male; Morpholinos; Prehypertension; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Cell Surface; RNA, Messenger; Time Factors; Up-Regulation; Vasodilator Agents | 2012 |
The coronary endothelium behaves as a functional diffusion barrier for intravascular Angiotensin II.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biotin; Coronary Vessels; Dextrans; Diffusion; Endothelium, Vascular; Losartan; Paracrine Communication; Polymers; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1 | 2013 |
Regulation of glomerulotubular balance: II: impact of angiotensin II on flow-dependent transport.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Bicarbonates; Biological Transport; Enzyme Inhibitors; Female; Hemostasis; In Vitro Techniques; Kidney Glomerulus; Kidney Tubules; Losartan; Macrolides; Mice; Mice, Knockout; Models, Animal; Proton-Translocating ATPases; Receptor, Angiotensin, Type 1; Sodium; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers | 2012 |
Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains.
Topics: Alzheimer Disease; Angiotensin II; Animals; Brain; Cognition; Dose-Response Relationship, Drug; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Indoles; Losartan; Male; Maleimides; Phosphorylation; Propranolol; Rats; Rats, Sprague-Dawley; Signal Transduction; tau Proteins | 2012 |
[Inhibitory effect of losartan on prostatic hyperplasia in spontaneous hypertension rats and its pathophysiological mechanism].
Topics: Angiotensin II; Animals; Antihypertensive Agents; Hypertension; Insulin-Like Growth Factor I; Interleukin-6; Losartan; Male; Nitric Oxide Synthase Type III; Prostate; Prostatic Hyperplasia; Rats; Rats, Inbred SHR | 2012 |
Intake of high sucrose during pregnancy altered large-conductance Ca2+-activated K+ channels and vessel tone in offspring's mesenteric arteries.
Topics: Angiotensin II; Animals; Animals, Newborn; Dietary Carbohydrates; Dose-Response Relationship, Drug; Female; Imidazoles; Large-Conductance Calcium-Activated Potassium Channels; Losartan; Membrane Potentials; Mesenteric Arteries; Models, Animal; Muscle, Smooth, Vascular; Pregnancy; Prenatal Exposure Delayed Effects; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Sucrose | 2013 |
Evaluating the potential for rostral diffusion in the cerebral ventricles using angiotensin II-induced drinking in rats.
Topics: Angiotensin II; Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Drinking; Drinking Behavior; Drug Evaluation, Preclinical; Injections, Intraventricular; Losartan; Male; Prosencephalon; Rats; Rats, Sprague-Dawley | 2012 |
Ethanol and vitamin D receptor in T cell apoptosis.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Annexin A5; Apoptosis; Blotting, Western; Cell Survival; Central Nervous System Depressants; DNA Breaks, Double-Stranded; DNA Repair; Enzyme-Linked Immunosorbent Assay; Ethanol; Fluorescent Antibody Technique; Humans; In Situ Nick-End Labeling; Jurkat Cells; Kinetics; Losartan; Reactive Oxygen Species; Receptors, Calcitriol; Renin-Angiotensin System; T-Lymphocytes | 2013 |
Transient prehypertensive treatment in spontaneously hypertensive rats: a comparison of losartan and amlodipine regarding long-term blood pressure, cardiac and renal protection.
Topics: Aldosterone; Amlodipine; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cardiotonic Agents; Collagen; Gene Expression Regulation; Heart Ventricles; Hypertension; Hypertrophy, Left Ventricular; Kidney; Losartan; Male; Natriuretic Peptide, Brain; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Stroke Volume; Transforming Growth Factor beta1; Ultrasonography | 2012 |
Angiotensin II promotes iron accumulation and depresses PGI₂ and NO synthesis in endothelial cells: effects of losartan and propranolol analogs.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Cattle; Cell Survival; Cells, Cultured; Down-Regulation; Endothelium, Vascular; Epoprostenol; Glutathione; Iron; Iron Overload; Losartan; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Propranolol; Receptor, Angiotensin, Type 1 | 2012 |
Oxidative stress exaggerates skeletal muscle contraction-evoked reflex sympathoexcitation in rats with hypertension induced by angiotensin II.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Afferent Pathways; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Blood Pressure; Blotting, Western; Cardiovascular System; Cyclic N-Oxides; Decerebrate State; Disease Models, Animal; Electric Stimulation; Heart Rate; Hindlimb; Hypertension; Injections, Intra-Articular; Kidney; Losartan; Male; Membrane Glycoproteins; Muscle Contraction; Muscle, Skeletal; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reflex; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spin Labels; Superoxides; Sympathetic Nervous System; Time Factors | 2013 |
Arterial and venous endothelia display differential functional fractalkine (CX3CL1) expression by angiotensin-II.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apolipoproteins E; Arteries; Arterioles; Atherosclerosis; Cell Adhesion; Cells, Cultured; Chemokine CX3CL1; CX3C Chemokine Receptor 1; Disease Models, Animal; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Female; Human Umbilical Vein Endothelial Cells; Humans; Interferon-gamma; Leukocyte Rolling; Leukocytes; Losartan; Male; Membrane Glycoproteins; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidase 5; NADPH Oxidases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Receptors, Chemokine; RNA Interference; Signal Transduction; Time Factors; Transfection; Tumor Necrosis Factor-alpha; Veins; Venules | 2013 |
Angiotensin-2-mediated Ca2+ signaling in the retinal pigment epithelium: role of angiotensin-receptor-associated-protein and TRPV2 channel.
Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Calcium; Estrenes; Imidazoles; Immunohistochemistry; Losartan; Macrocyclic Compounds; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxazoles; Pyrrolidinones; Retinal Pigment Epithelium; RNA, Small Interfering; Signal Transduction; Swine; TRPV Cation Channels | 2012 |
Angiotensin II and III metabolism and effects on steroid production in the HAC15 human adrenocortical cell line.
Topics: 3-Hydroxysteroid Dehydrogenases; Adrenal Cortex; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin III; Cell Line; Cytochrome P-450 CYP11B2; Humans; Hydrocortisone; Losartan; Steroid 11-beta-Hydroxylase; Steroid 17-alpha-Hydroxylase | 2013 |
Inhibition of central angiotensin II enhances memory function and reduces oxidative stress status in rat hippocampus.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Avoidance Learning; Behavior, Animal; Captopril; Glutathione Peroxidase; Hippocampus; Imidazoles; Lipid Peroxidation; Losartan; Male; Malondialdehyde; Maze Learning; Memory; Memory, Short-Term; Oxidative Stress; Psychomotor Performance; Pyridines; Rats; Rats, Wistar; Superoxide Dismutase | 2013 |
Angiotensin II induces the production of MMP-3 and MMP-13 through the MAPK signaling pathways via the AT(1) receptor in osteoblasts.
Topics: Alkaline Phosphatase; Angiotensin II; Animals; Cell Line, Tumor; Cell Proliferation; Gelatin; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Losartan; MAP Kinase Signaling System; Matrix Metalloproteinase 13; Matrix Metalloproteinase 3; Mice; Osteoblasts; Phosphorylation; Plasminogen Activator Inhibitor 1; Plasminogen Activators; Pyridines; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tissue Inhibitor of Metalloproteinases | 2013 |
Angiotensin II and angiotensin-(1-7) in paraventricular nucleus modulate cardiac sympathetic afferent reflex in renovascular hypertensive rats.
Topics: Afferent Pathways; Angiotensin I; Angiotensin II; Animals; Blood Pressure; Body Weight; Heart; Heart Rate; Hypertension, Renovascular; Kidney; Losartan; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Reflex; Sympathetic Nervous System; Systole | 2012 |
Cross talk between toll-like receptor-4 signaling and angiotensin-II in liver fibrosis development in the rat model of non-alcoholic steatohepatitis.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Communication; Disease Models, Animal; Disease Progression; DNA Primers; Dose-Response Relationship, Drug; Fatty Liver; Gene Expression; Hepatic Stellate Cells; Liver Cirrhosis; Losartan; Male; NF-kappa B; Non-alcoholic Fatty Liver Disease; Rats; Rats, Inbred F344; Real-Time Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Toll-Like Receptor 4; Transforming Growth Factor beta | 2013 |
Angiotensin II promotes differentiation of mouse embryonic stem cells to smooth muscle cells through PI3-kinase signaling pathway and NF-κB.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Cell Differentiation; Cell Line; Collagen; Embryonic Stem Cells; Imidazoles; Losartan; Mice; Myocytes, Smooth Muscle; NF-kappa B; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Sulfones | 2013 |
Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model.
Topics: Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blotting, Western; Fibrosis; Hypertrophy, Left Ventricular; Losartan; Male; Myocardium; Physical Conditioning, Animal; Rats; Rats, Wistar; RNA, Messenger | 2013 |
[Effects of angiotensin II and its receptor blockers on migration and endothelin-1 expression of rat vascular adventitial fibroblast subpopulations].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cell Movement; Cells, Cultured; Endothelin-1; Fibroblasts; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Vasoconstrictor Agents | 2012 |
Angiotensin III stimulates high stretch-induced ANP secretion via angiotensin type 2 receptor.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin III; Animals; Atrial Natriuretic Factor; Dose-Response Relationship, Drug; Heart Atria; Imidazoles; In Vitro Techniques; Infusions, Intravenous; Losartan; Male; Myocardial Contraction; Perfusion; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Signal Transduction | 2013 |
AngII-induced glomerular mesangial cell proliferation inhibited by losartan via changes in intracellular calcium ion concentration.
Topics: Angiotensin II; Blotting, Western; Calcium; Cations, Divalent; Cell Line; Cell Proliferation; Cytoplasm; Gene Expression Profiling; Humans; Losartan; Mesangial Cells; Microscopy, Confocal; Reverse Transcriptase Polymerase Chain Reaction; Staining and Labeling; Tetrazolium Salts; Thiazoles; TRPC Cation Channels; TRPC6 Cation Channel; Trypan Blue | 2014 |
Angiotensin II-mediated vascular changes in aged offspring rats exposed to perinatal nicotine.
Topics: Acetylcholine; Aging; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Abdominal; Blood Pressure; Female; In Vitro Techniques; Losartan; Male; Maternal-Fetal Exchange; Mesenteric Arteries; Muscle, Smooth, Vascular; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Vasodilation; Vasodilator Agents | 2013 |
Angiotensin II upregulates K(Ca)3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Proliferation; Fibroblasts; Gene Expression Regulation; Heart Ventricles; Intermediate-Conductance Calcium-Activated Potassium Channels; Losartan; Male; p38 Mitogen-Activated Protein Kinases; Patch-Clamp Techniques; Primary Cell Culture; Protein Kinase Inhibitors; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Signal Transduction; Transcription Factor AP-1; Up-Regulation; Vasoconstrictor Agents | 2013 |
A novel role for c-Myc in G protein-coupled receptor kinase 4 (GRK4) transcriptional regulation in human kidney proximal tubule cells.
Topics: Angiotensin II; Cell Line; Cells, Cultured; G-Protein-Coupled Receptor Kinase 4; Humans; Kidney Tubules, Proximal; Losartan; Oxadiazoles; Phorbol Esters; Proto-Oncogene Proteins c-myc; Receptor, Angiotensin, Type 1; Receptors, Dopamine; Transcription, Genetic | 2013 |
The effects of para-chloromercuribenzoic acid and different oxidative and sulfhydryl agents on a novel, non-AT1, non-AT2 angiotensin binding site identified as neurolysin.
Topics: Angiotensin I; Angiotensin II; Angiotensins; Animals; Binding Sites; Losartan; Male; Metalloendopeptidases; Oxidation-Reduction; p-Chloromercuribenzoic Acid; Rats; Sulfhydryl Compounds | 2013 |
Heart failure and angiotensin II modulate atrial Pitx2c promotor methylation.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Azacitidine; Cell Line, Tumor; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Drug Interactions; Enzyme Inhibitors; Heart Atria; Heart Failure; Homeobox Protein PITX2; Homeodomain Proteins; Isoproterenol; Losartan; Male; Promoter Regions, Genetic; Rats; RNA; Transcription Factors | 2013 |
Shear stress activates extracellular signal-regulated kinase 1/2 via the angiotensin II type 1 receptor.
Topics: Acetophenones; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Caveolin 1; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Human Umbilical Vein Endothelial Cells; Humans; Immunohistochemistry; Losartan; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Protein Binding; Receptor, Angiotensin, Type 1; RNA Interference; Stress, Mechanical | 2013 |
Angiotensin AT(1)-receptor blockers enhance cardiac responses to parasympathetic nerve stimulation via presynaptic AT(1) receptors in pithed rats.
Topics: Acetylcholine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Bradycardia; Electric Stimulation; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Presynaptic; Tetrazoles; Vagus Nerve | 2013 |
Angiotensin-converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4-deficient mice.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm; Biomarkers; Biomechanical Phenomena; Blood Pressure; Captopril; Cell Differentiation; Extracellular Matrix Proteins; Extracellular Signal-Regulated MAP Kinases; Gene Deletion; Losartan; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Peptidyl-Dipeptidase A; Phenotype; Phosphorylation; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Signal Transduction; Time Factors; Up-Regulation | 2013 |
Characterization of ion currents of murine CD117(pos) stem cells in vitro and their modulation under AT2 R stimulation.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cardiotonic Agents; Cell Differentiation; Endothelial Cells; Heart; Hematopoietic Stem Cells; In Vitro Techniques; Lipoproteins, LDL; Losartan; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Proto-Oncogene Proteins c-kit; Pyrimidines; Receptor, Angiotensin, Type 2; Regeneration; RNA, Messenger; Vasoconstrictor Agents | 2013 |
The protective effects of beta-casomorphin-7 against glucose -induced renal oxidative stress in vivo and vitro.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Cell Line; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Endorphins; Epithelial Cells; Glucagon; Glutathione Peroxidase; Hydrogen Peroxide; Insulin; Isoenzymes; Kidney; Losartan; Male; Malondialdehyde; Oxidative Stress; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2013 |
The arrestin-selective angiotensin AT1 receptor agonist [Sar1,Ile4,Ile8]-AngII negatively regulates bradykinin B2 receptor signaling via AT1-B2 receptor heterodimers.
Topics: Allosteric Site; Angiotensin II; Animals; Aorta; Arrestins; Calcium; Dimerization; Dose-Response Relationship, Drug; GTP-Binding Proteins; HEK293 Cells; Hemodynamics; Humans; Kallikreins; Ligands; Losartan; Myocytes, Smooth Muscle; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Bradykinin B2; Signal Transduction | 2013 |
Antinociceptive response in transgenic mice expressing rat tonin.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Behavior, Animal; Disease Models, Animal; Losartan; Male; Mice; Mice, Transgenic; Nociception; Nociceptive Pain; Pain Measurement; Peptide Fragments; Rats; Receptors, G-Protein-Coupled; Tissue Kallikreins | 2013 |
Pioglitazone enhances the blood pressure-lowering effect of losartan via synergistic attenuation of angiotensin II-induced vasoconstriction.
Topics: Acetylcholine; Angiotensin II; Animals; Aorta; Blood Pressure; Drug Synergism; Endothelium, Vascular; Losartan; Male; NADPH Oxidases; Nitric Oxide Synthase Type III; Nitroprusside; Phenylephrine; Pioglitazone; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Systole; Thiazolidinediones; Tyrosine; Vasoconstriction; Vasodilation | 2014 |
Role of angiotensin AT2 receptors and nitric oxide in the cardiopulmonary baroreflex control of renal sympathetic nerve activity in rats.
Topics: Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Baroreflex; Blood Pressure; Enzyme Inhibitors; Imidazoles; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oligopeptides; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 2; Sympathetic Nervous System | 2013 |
Hsp70 regulation on Nox4/p22phox and cytoskeletal integrity as an effect of losartan in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Caveolin 1; Cells, Cultured; Cytoskeleton; HSP70 Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Losartan; Male; Muscle, Smooth, Vascular; NADPH Oxidase 4; NADPH Oxidases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Receptor, Angiotensin, Type 1; rhoA GTP-Binding Protein | 2014 |
Angiotensin AT2 receptor agonist stimulates high stretch induced- ANP secretion via PI3K/NO/sGC/PKG/pathway.
Topics: Angiotensin II; Animals; Atrial Natriuretic Factor; Atrial Pressure; Cyclic GMP-Dependent Protein Kinases; Gene Expression Regulation; Guanylate Cyclase; Heart Atria; Hypertension, Renal; Imidazoles; Losartan; Male; Nitric Oxide; Oligopeptides; Peptide Fragments; Phosphatidylinositol 3-Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Tissue Culture Techniques; Vasodilator Agents | 2013 |
The effect of high-fructose intake on the vasopressor response to angiotensin II and adrenergic agonists in Sprague-Dawley rats.
Topics: Angiotensin II; Animals; Fructose; Hemodynamics; Losartan; Male; Methoxamine; Norepinephrine; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2 | 2013 |
A modified rat model of exercise-induced renal injury and the protective effects of losartan and yishen huanji decoction.
Topics: Acute Kidney Injury; Angiotensin II; Animals; Blood Urea Nitrogen; Disease Models, Animal; Drugs, Chinese Herbal; Environment; Losartan; Male; Motor Activity; Protective Agents; Rats; Rats, Sprague-Dawley; Treatment Outcome; Urinalysis | 2013 |
Fluorofenidone inhibits nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis.
Topics: Angiotensin II; Animals; Antioxidants; Cell Line; Class Ia Phosphatidylinositol 3-Kinase; Collagen Type I; Dinoprost; Disease Models, Animal; Enzyme Inhibitors; Fibrosis; Kidney Diseases; Kidney Tubules; Lipid Peroxidation; Losartan; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridones; Rats; Rats, Sprague-Dawley; Signal Transduction; Transfection; Ureteral Obstruction | 2013 |
Effects of cyclic stretch on the molecular regulation of myocardin in rat aortic vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Humans; Losartan; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nuclear Proteins; Promoter Regions, Genetic; Rats; Signal Transduction; Stress, Mechanical; Trans-Activators | 2013 |
Angiotensin-(1-7) attenuates lung fibrosis by way of Mas receptor in acute lung injury.
Topics: Acute Lung Injury; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, Animal; Lipopolysaccharides; Losartan; Male; Mice; Mice, Inbred C57BL; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pulmonary Fibrosis; Receptors, G-Protein-Coupled; Respiratory Distress Syndrome; Vasodilator Agents | 2013 |
Renin angiotensin system blockade ameliorates lead nephropathy.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Gene Expression Regulation; Glomerular Filtration Rate; Kidney Diseases; Lead Poisoning; Losartan; Male; Peptidyl-Dipeptidase A; Proteinuria; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Transforming Growth Factor beta | 2013 |
Angiotensin II produces nociceptive behavior through spinal AT1 receptor-mediated p38 mitogen-activated protein kinase activation in mice.
Topics: Angiotensin II; Animals; Imidazoles; Losartan; Male; MAP Kinase Signaling System; Mice; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptor, Angiotensin, Type 1; Spinal Cord | 2013 |
Protective effects of angiotensin-(1-7) administrated with an angiotensin-receptor blocker in a rat model of chronic kidney disease.
Topics: Angiopoietins; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, Animal; Fibronectins; Losartan; Male; Nephrectomy; Peptide Fragments; Plasminogen Activator Inhibitor 1; Rats, Sprague-Dawley; Receptor, TIE-2; Renal Insufficiency, Chronic; Systole | 2013 |
Effects of acute and subchronic AT1 receptor blockade on cardiovascular, hydromineral and neuroendocrine responses in female rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arterial Pressure; Atrial Natriuretic Factor; Estradiol; Female; Heart Rate; Losartan; Ovariectomy; Oxytocin; Rats; Rats, Wistar; Sodium; Vasopressins | 2013 |
Intravital Förster resonance energy transfer imaging reveals elevated [Ca2+]i and enhanced sympathetic tone in femoral arteries of angiotensin II-infused hypertensive biosensor mice.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biosensing Techniques; Calcium; Calcium Signaling; Calmodulin; Femoral Artery; Fluorescence Resonance Energy Transfer; Hexamethonium; Hypertension; Infusions, Intravenous; Losartan; Mice; Muscle, Smooth, Vascular; Prazosin; Sympathetic Nervous System; Vasoconstriction | 2013 |
Exposure of cardiomyocytes to angiotensin II induces over-activation of monoamine oxidase type A: implications in heart failure.
Topics: Aldehyde Dehydrogenase; Angiotensin II; Animals; Biphenyl Compounds; Catalase; Enzyme Activation; Heart Failure; Hyperglycemia; Irbesartan; Losartan; Monoamine Oxidase; Myocytes, Cardiac; Rats; Tetrazoles | 2013 |
Angiotensin II induces C-reactive protein expression via AT1-ROS-MAPK-NF-κB signal pathway in hepatocytes.
Topics: Acetylcysteine; Angiotensin II; Animals; C-Reactive Protein; Cell Line; Hepatocytes; Humans; JNK Mitogen-Activated Protein Kinases; Losartan; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Recombinant Proteins; RNA, Messenger; Signal Transduction; Thenoyltrifluoroacetone | 2013 |
The renin-angiotensin system plays a major role in voiding dysfunction of ovariectomized rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Carbachol; Dose-Response Relationship, Drug; Estradiol; Female; In Vitro Techniques; Losartan; Lower Urinary Tract Symptoms; Ovariectomy; Peptidyl-Dipeptidase A; Phenylephrine; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Urethra; Urinary Bladder; Urination; Vasoconstrictor Agents | 2013 |
Losartan reverses glomerular podocytes injury induced by AngII via stabilizing the expression of GLUT1.
Topics: Angiotensin II; Gene Expression Regulation; Glucose Transporter Type 1; Humans; Losartan; Podocytes; RNA, Messenger; Time Factors | 2013 |
[Effect of angiotensin II and aldosterone on the proliferation of cardiac fibroblasts in rats].
Topics: Aldosterone; Angiotensin II; Animals; Cell Proliferation; Collagen; Fibroblasts; Losartan; Myocardium; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spironolactone | 2013 |
Angiotensin II type 2 receptor correlates with therapeutic effects of losartan in rats with adjuvant-induced arthritis.
Topics: Angiotensin II; Animals; Ankle Joint; Arthritis, Experimental; Cells, Cultured; Chemotaxis; Injections, Intra-Articular; Losartan; Male; Monocytes; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Endothelial Growth Factor A | 2013 |
Ang II enhances noradrenaline release from sympathetic nerve endings thus contributing to the up-regulation of metalloprotease-2 in aortic dissection patients' aorta wall.
Topics: Adrenergic Fibers; Angiotensin II; Animals; Aorta; Aortic Dissection; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Enzymologic; Humans; Isotope Labeling; Losartan; Matrix Metalloproteinase 2; Norepinephrine; Rats; Rats, Sprague-Dawley | 2013 |
Endothelium-dependent relaxation and angiotensin II sensitivity in experimental preeclampsia.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Endothelial Cells; Female; Imidazoles; Lipopolysaccharides; Losartan; Nitric Oxide Synthase Type II; Pre-Eclampsia; Pregnancy; Prostaglandins; Pyridines; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Vasodilator Agents | 2013 |
Reduced sarcolemmal expression and function of the NBCe1 isoform of the Na⁺-HCO₃⁻ cotransporter in hypertrophied cardiomyocytes of spontaneously hypertensive rats: role of the renin-angiotensin system.
Topics: Ammonium Compounds; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Bicarbonates; Cardiomegaly; Disease Models, Animal; Down-Regulation; Endosomes; Hydrogen-Ion Concentration; Hyperkalemia; Hypertension; Losartan; Male; Myocytes, Cardiac; Potassium; Protein Transport; Rats; Rats, Inbred SHR; Rats, Wistar; Renin-Angiotensin System; Sarcolemma; Sodium-Bicarbonate Symporters; Time Factors | 2014 |
Cardiovascular effect of angiotensin-(1-12) in the caudal ventrolateral medullary depressor area of the rat.
Topics: Adrenergic alpha-1 Receptor Agonists; Angiotensin II; Angiotensinogen; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Captopril; Heart Rate; Losartan; Male; Medulla Oblongata; Nitroprusside; Peptide Fragments; Phenylephrine; Rats; Rats, Wistar; Vasomotor System | 2014 |
Enhanced angiotensin-converting enzyme activity and systemic reactivity to angiotensin II in normotensive rats exposed to a high-sodium diet.
Topics: Aldosterone; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Pressure; Losartan; Male; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Sodium Chloride, Dietary | 2014 |
Long-term prehypertension treatment with losartan effectively prevents brain damage and stroke in stroke-prone spontaneously hypertensive rats.
Topics: Aldosterone; Amlodipine; Angiotensin II; Animals; Apoptosis; Blood Pressure; Brain; Hypertension; Losartan; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Prehypertension; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Stroke; Superoxide Dismutase; Time Factors | 2014 |
Chronic infusion of enalaprilat into hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension and cardiac hypertrophy by restoring neurotransmitters and cytokines.
Topics: Angiotensin II; Animals; Cardiomegaly; Chemokine CCL2; Enalaprilat; gamma-Aminobutyric Acid; Glutamic Acid; Heart; Hypertension; Interleukin-10; Interleukin-1beta; Interleukin-6; Kidney; Losartan; Male; Neurotransmitter Agents; Norepinephrine; Organ Size; Paraventricular Hypothalamic Nucleus; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System | 2014 |
Vascular aldosterone production at the pre-diabetic stage of young Otsuka Long-Evans Tokushima Fatty (OLETF) rats, compared with Long-Evans Tokushima Otsuka (LETO) rats.
Topics: Aldosterone; Angiotensin II; Animals; Aorta; Blood Vessels; Cholesterol, HDL; Cytochrome P-450 CYP11B2; Gene Expression; Losartan; Myocytes, Smooth Muscle; Prediabetic State; Rats; Rats, Inbred OLETF; RNA, Messenger | 2013 |
Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Aortic Aneurysm; Cells, Cultured; Disease Progression; Female; Haploinsufficiency; Humans; Loeys-Dietz Syndrome; Losartan; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Mutation, Missense; Myocytes, Smooth Muscle; Phenotype; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta | 2014 |
Angiotensin II evokes angiogenic signals within skeletal muscle through co-ordinated effects on skeletal myocytes and endothelial cells.
Topics: Angiotensin II; Angiotensinogen; Animals; Cell Line; Endothelial Cells; Extracellular Matrix; Losartan; Male; Matrix Metalloproteinase 2; Mice; Mice, Knockout; Microvessels; Muscle Fibers, Skeletal; Muscle, Skeletal; Neovascularization, Physiologic; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Signal Transduction; Vascular Endothelial Growth Factor A | 2014 |
Angiotensin II promotes the progression of human gastric cancer.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Gastric Mucosa; Humans; Losartan; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Peptidyl-Dipeptidase A; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Stomach Neoplasms; Transplantation, Heterologous | 2014 |
Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cardiomegaly; Gene Expression Regulation; Losartan; Metformin; Mitochondria; Myocytes, Cardiac; Nitric Oxide Synthase Type III; Rats; Receptor, Angiotensin, Type 1; Signal Transduction; Sirtuin 1; Tumor Suppressor Protein p53 | 2014 |
Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Line; Epithelial Cells; Female; Humans; In Vitro Techniques; Ion Transport; Losartan; Lung; Receptor, Angiotensin, Type 1; Respiratory Mucosa; Xenopus laevis; Xenopus Proteins | 2014 |
Angiotensin II-induced cardiovascular load regulates cardiac remodeling and related gene expression in late-gestation fetal sheep.
Topics: Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cardiovascular Physiological Phenomena; Cell Proliferation; Female; Fetus; Gene Expression Regulation, Developmental; Immunoblotting; Losartan; Microarray Analysis; Myocytes, Cardiac; Pregnancy; Sheep; Ventricular Remodeling | 2014 |
Mechanisms of AT1a receptor-mediated uptake of angiotensin II by proximal tubule cells: a novel role of the multiligand endocytic receptor megalin.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cells, Cultured; Endocytosis; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fluorescein-5-isothiocyanate; Kidney Tubules, Proximal; Ligands; Losartan; Low Density Lipoprotein Receptor-Related Protein-2; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Receptor, Angiotensin, Type 1; RNA Interference; Signal Transduction; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Transfection | 2014 |
Gestational exposure to elevated testosterone levels induces hypertension via heightened vascular angiotensin II type 1 receptor signaling in rats.
Topics: Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; Female; Hypertension, Pregnancy-Induced; Losartan; Mesenteric Arteries; Pregnancy; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Testosterone | 2014 |
Blockade of renin-angiotensin system prevents micturition dysfunction in renovascular hypertensive rats.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Animals; Antihypertensive Agents; Atenolol; Blood Pressure; Body Weight; Captopril; Cyclic AMP; Electric Stimulation; Female; Hypertension, Renovascular; Losartan; Male; Muscle Relaxation; Rats; Renin-Angiotensin System; Urethra; Urinary Bladder; Urination | 2014 |
High phosphate diet increases arterial blood pressure via a parathyroid hormone mediated increase of renin.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Diet; Kidney; Losartan; Male; Parathyroid Hormone; Parathyroidectomy; Phosphates; Rats; Rats, Sprague-Dawley; Renin; Renin-Angiotensin System; Verapamil | 2014 |
Mechanisms involving Ang II and MAPK/ERK1/2 signaling pathways underlie cardiac and renal alterations during chronic undernutrition.
Topics: Adenosine Triphosphatases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cardiomegaly; Cation Transport Proteins; Cyclic AMP-Dependent Protein Kinases; Heart; Heart Rate; Kidney Tubules, Proximal; Losartan; Male; Malnutrition; MAP Kinase Signaling System; Myocytes, Cardiac; Plasma Volume; Protein Kinase C; Rats; Rats, Wistar; Receptor, Angiotensin, Type 2; Sodium-Potassium-Exchanging ATPase | 2014 |
Role of CD2-associated protein in podocyte apoptosis and proteinuria induced by angiotensin II.
Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Apoptosis; Cells, Cultured; Cytoskeletal Proteins; Humans; Losartan; Podocytes; Proteinuria | 2014 |
Uremic conditions drive human monocytes to pro-atherogenic differentiation via an angiotensin-dependent mechanism.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Atherosclerosis; Captopril; Cell Adhesion; Cell Line; Cell Movement; Cell Proliferation; Humans; Lipopolysaccharides; Losartan; Monocytes; Peptidyl-Dipeptidase A; Uremia | 2014 |
The angiotensin II type 1 receptor (AT1R) closely interacts with large conductance voltage- and Ca2+-activated K+ (BK) channels and inhibits their activity independent of G-protein activation.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Calcium Signaling; Fluorescence Resonance Energy Transfer; Green Fluorescent Proteins; GTP-Binding Proteins; HEK293 Cells; Humans; Large-Conductance Calcium-Activated Potassium Channels; Losartan; Muscle Cells; Patch-Clamp Techniques; Rats; Receptor, Angiotensin, Type 1; Renal Artery | 2014 |
Angiotensin II enhances endothelin-1-induced vasoconstriction through upregulating endothelin type A receptor.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Aorta, Thoracic; Cell Line; Endothelin-1; Imidazoles; Losartan; Male; MAP Kinase Signaling System; Myocytes, Smooth Muscle; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Up-Regulation; Vasoconstriction | 2014 |
Enhancement of renal oxidative stress by injection of angiotensin II into the paraventricular nucleus in renal ischemia-reperfusion injury.
Topics: Acetylglucosaminidase; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Creatinine; Kidney; Losartan; Male; Malondialdehyde; Microinjections; Oxidative Stress; Paraventricular Hypothalamic Nucleus; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase | 2014 |
Angiotensin II in paraventricular nucleus contributes to sympathoexcitation in renal ischemia-reperfusion injury by AT1 receptor and oxidative stress.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Blood Pressure; Cyclic N-Oxides; Dose-Response Relationship, Drug; Kidney; Kidney Diseases; Losartan; Male; Oxidative Stress; Paraventricular Hypothalamic Nucleus; Rats, Sprague-Dawley; Receptors, Angiotensin; Reperfusion Injury; Spin Labels; Sympathetic Nervous System | 2015 |
Novel mechanism of intra‑renal angiotensin II-induced sodium/proton exchanger 3 expression by losartan in spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Female; Gene Expression; Hypertension; Immediate-Early Proteins; Kidney; Losartan; Male; Protein Serine-Threonine Kinases; Rats, Inbred SHR; Rats, Inbred WKY; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Transcriptional Activation | 2014 |
Role of vascular smooth muscle PPARγ in regulating AT1 receptor signaling and angiotensin II-dependent hypertension.
Topics: Angiotensin II; Animals; Arterial Pressure; Extracellular Signal-Regulated MAP Kinases; Humans; Hypertension; Losartan; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; PPAR gamma; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Signal Transduction; Vasoconstriction | 2014 |
High-salt intake induces cardiomyocyte hypertrophy in rats in response to local angiotensin II type 1 receptor activation.
Topics: Acetylcysteine; Aldosterone; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Cardiomegaly; Heart Rate; Hematocrit; Hydralazine; Losartan; Male; Myocytes, Cardiac; Potassium; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Sodium; Sodium Chloride, Dietary; Thiobarbituric Acid Reactive Substances | 2014 |
Participation of AT1 and Mas receptors in the modulation of inflammatory pain.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Inflammation; Losartan; Male; Mice; Mice, Knockout; Pain; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled | 2014 |
Angiotensin II mobilizes intracellular calcium and activates pannexin-1 channels in rat carotid body type II cells via AT1 receptors.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Ulcer Agents; Calcium; Carbenoxolone; Carotid Body; Cells, Cultured; Connexins; Gene Expression Regulation; Losartan; Nerve Tissue Proteins; Rats; Receptor, Angiotensin, Type 1; Signal Transduction | 2014 |
Effect of angiotensin II on STAT3 mediated atrial structural remodeling.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Apoptosis; Cells, Cultured; Collagen Type I; Collagen Type III; Fibroblasts; Heart Atria; Humans; Losartan; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Myocytes, Cardiac; Receptor, Angiotensin, Type 1; STAT3 Transcription Factor | 2014 |
Systemic angiotensin II and exercise-induced neurogenesis in adult rat hippocampus.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Bromodeoxyuridine; Cell Count; Dentate Gyrus; Doublecortin Domain Proteins; Doublecortin Protein; Immunohistochemistry; Losartan; Male; Microtubule-Associated Proteins; Neurogenesis; Neurons; Neuropeptides; Photomicrography; Rats, Wistar; Receptor, Angiotensin, Type 1; Running | 2014 |
Role of nephrin in podocyte injury induced by angiotension II.
Topics: Angiotensin II; Anti-Arrhythmia Agents; Apoptosis; Blotting, Western; Cell Proliferation; Cells, Cultured; Humans; Kidney Diseases; Kidney Glomerulus; Losartan; Membrane Proteins; Podocytes; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vasoconstrictor Agents | 2016 |
Design, synthesis and pharmacological evaluation of novel NO-releasing benzimidazole hybrids as potential antihypertensive candidate.
Topics: Administration, Oral; Angiotensin II; Animals; Antihypertensive Agents; Aorta, Thoracic; Benzimidazoles; Drug Design; Losartan; Male; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Wistar; Vasoconstriction | 2015 |
Angiotensin-(1-7) modulates angiotensin II-induced vasoconstriction in human mammary artery.
Topics: Aged; Aged, 80 and over; Angiotensin I; Angiotensin II; Endothelium, Vascular; Female; Humans; Losartan; Male; Mammary Arteries; Middle Aged; Myocytes, Smooth Muscle; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Renin-Angiotensin System; Vasoconstriction | 2014 |
An interaction of renin-angiotensin and kallikrein-kinin systems contributes to vascular hypertrophy in angiotensin II-induced hypertension: in vivo and in vitro studies.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Bradykinin B1 Receptor Antagonists; Cells, Cultured; Drug Synergism; Hypertension; Hypertrophy; Kallikrein-Kinin System; Losartan; Male; Myocytes, Smooth Muscle; Rats; Rats, Wistar; Reactive Oxygen Species; Receptor, Bradykinin B1; Renin-Angiotensin System; Superoxides | 2014 |
Role of Mas receptor antagonist (A779) on pressure diuresis and natriuresis and renal blood flow in the absence of angiotensin II receptors type 1 and 2 in female and male rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Diuresis; Female; Imidazoles; Kidney; Losartan; Male; Natriuresis; Peptide Fragments; Pressure; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pyridines; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Renal Circulation; Sex Factors; Vascular Resistance | 2014 |
Impact of losartan and angiotensin II on the expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in rat vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Cells, Cultured; Gene Expression Regulation; Losartan; Matrix Metalloproteinase 9; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1 | 2015 |
Intracerebroventricular infusion of the (Pro)renin receptor antagonist PRO20 attenuates deoxycorticosterone acetate-salt-induced hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Baroreflex; Binding, Competitive; Blood Pressure; Calcium; Captopril; Cell Line, Tumor; Desoxycorticosterone Acetate; Extracellular Signal-Regulated MAP Kinases; Humans; Hypertension; Hypothalamus; Infusions, Intraventricular; Ion Transport; Losartan; Mice; Mice, Inbred C57BL; Neuroblastoma; Peptide Fragments; Phosphorylation; Prorenin Receptor; Protein Processing, Post-Translational; Receptors, Cell Surface; Renin; Sodium Chloride; Vacuolar Proton-Translocating ATPases | 2015 |
Overactive cannabinoid 1 receptor in podocytes drives type 2 diabetic nephropathy.
Topics: Analysis of Variance; Angiotensin II; Animals; Arachidonic Acids; Desmin; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Gene Expression Regulation; Losartan; Models, Biological; Podocytes; Pyrazoles; Rats; Rats, Zucker; Receptor, Angiotensin, Type 1; Receptor, Cannabinoid, CB1; RNA Interference; RNA, Small Interfering; Sulfonamides | 2014 |
The intrathecal administration of losartan, an AT1 receptor antagonist, produces an antinociceptive effect through the inhibiton of p38 MAPK phosphorylation in the mouse formalin test.
Topics: Analgesics; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Injections, Spinal; Losartan; Lumbosacral Region; Male; Mice; p38 Mitogen-Activated Protein Kinases; Pain; Pain Measurement; Phosphorylation; Spinal Cord | 2015 |
Angiotensin IV stimulates high atrial stretch-induced ANP secretion via insulin regulated aminopeptidase.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atrial Natriuretic Factor; Biomechanical Phenomena; Blood Pressure; CD13 Antigens; Extracellular Fluid; Heart Atria; Insulin; Losartan; Male; Myocardial Contraction; Rats, Sprague-Dawley; Signal Transduction | 2015 |
Elevated pressure causes endothelial dysfunction in mouse carotid arteries by increasing local angiotensin signaling.
Topics: Acetylcholine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Carotid Arteries; Endothelium, Vascular; Hydrazines; Hypertension; Indoles; Losartan; Male; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Signal Transduction; Tetrazoles; Valine; Valsartan; Vasodilation | 2015 |
Up-regulation of intrarenal renin-agiotensin system contributes to renal damage in high-salt induced hypertension rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Diet; Hypertension, Renal; Kidney; Losartan; Male; Proteinuria; Rats; Rats, Wistar; Renin; Renin-Angiotensin System; RNA, Messenger; Sodium Chloride, Dietary; Up-Regulation | 2014 |
Experimental gestational diabetes mellitus induces blunted vasoconstriction and functional changes in the rat aorta.
Topics: Angiotensin II; Animals; Diabetes Mellitus, Experimental; Diabetes, Gestational; Female; Humans; Losartan; Phenylephrine; Pregnancy; Rats; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2014 |
Activation of the renin-angiotensin system stimulates biliary hyperplasia during cholestasis induced by extrahepatic bile duct ligation.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Bile Ducts, Extrahepatic; Cell Line; Cell Proliferation; Cholestasis, Extrahepatic; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Hyperplasia; Ligation; Losartan; Male; Rats, Inbred F344; Renin-Angiotensin System; Signal Transduction | 2015 |
Angiotensin II and its receptor in activated microglia enhanced neuronal loss and cognitive impairment following pilocarpine-induced status epilepticus.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cognition Disorders; Hippocampus; Losartan; Male; Microglia; Neurons; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Status Epilepticus | 2015 |
Angiotensin II promotes melanogenesis via angiotensin II type 1 receptors in human melanocytes.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Carcinogenesis; Humans; Losartan; Melanins; Melanocytes; Melanoma; Primary Cell Culture; Receptor, Angiotensin, Type 1; Signal Transduction | 2015 |
The effect of losartan on differential reflex control of sympathetic nerve activity in chronic kidney disease.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Autonomic Pathways; Baroreflex; Kidney; Losartan; Lumbosacral Region; Male; Nitroprusside; Phenylephrine; Rats; Rats, Inbred Lew; Receptor, Angiotensin, Type 1; Renal Insufficiency, Chronic; Sympathetic Nervous System | 2015 |
Characterization and functions of vascular adventitial fibroblast subpopulations.
Topics: Adventitia; Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Aorta, Thoracic; Cell Lineage; Cell Movement; Cell Proliferation; Cells, Cultured; Collagen Type I; Endothelin-1; Fibroblasts; Imidazoles; Losartan; Male; Pyridines; Rats; RNA, Messenger | 2015 |
Losartan treating podocyte injury induced by Ang II via downregulation of TRPC6 in podocytes.
Topics: Angiotensin II; Animals; Blotting, Western; Down-Regulation; Losartan; Mice; Podocytes; RNA, Messenger; Time Factors; TRPC Cation Channels | 2015 |
Activation of renin-angiotensin-aldosterone system (RAAS) in the lung of smoking-induced pulmonary arterial hypertension (PAH) rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Blood Pressure; Blotting, Western; Heart Ventricles; Hypertension, Pulmonary; Losartan; Lung; Male; Peptidyl-Dipeptidase A; Rats, Sprague-Dawley; Renin-Angiotensin System; Smoking; Systole | 2015 |
Effect of angiotensin II on voltage-gated sodium currents in aortic baroreceptor neurons and arterial baroreflex sensitivity in heart failure rats.
Topics: Angiotensin II; Animals; Aorta; Arteries; Baroreflex; Chronic Disease; Disease Models, Animal; Heart Failure; Losartan; Male; Neurons; Nodose Ganglion; Pressoreceptors; Rats; Rats, Sprague-Dawley; Sodium; Voltage-Gated Sodium Channels | 2015 |
Hippocampal asymmetry in angiotensin II modulatory effects on learning and memory in rats.
Topics: Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Avoidance Learning; Drug Combinations; Functional Laterality; Hippocampus; Losartan; Male; Microinjections; Rats; Rats, Wistar; Vasoconstrictor Agents | 2015 |
Angiotensin type 1 receptor mediates chronic ethanol consumption-induced hypertension and vascular oxidative stress.
Topics: Alcohol Drinking; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Arteries; Blood Pressure; Ethanol; Hypertension; Losartan; Male; Oxidative Stress; Phosphorylation; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Vasoconstriction | 2015 |
Losartan and Sodium Nitroprusside Effectively Protect against Renal Impairments after Ischemia and Reperfusion in Rats.
Topics: Adenosine Triphosphatases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arginine; Captopril; Ischemia; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitroprusside; Peptides, Cyclic; Rats, Wistar; Renal Insufficiency; Reperfusion; Reperfusion Injury | 2015 |
Losartan reverses the down-expression of long noncoding RNA-NR024118 and Cdkn1c induced by angiotensin II in adult rat cardiac fibroblasts.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p57; Down-Regulation; Fibroblasts; Imidazoles; Losartan; Male; Myocardium; Pyridines; Random Allocation; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Long Noncoding | 2015 |
Losartan treatment attenuates tumor-induced myocardial dysfunction.
Topics: Adenocarcinoma; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Calcium Signaling; Cardiotonic Agents; Cardiovascular Diseases; Cell Line, Tumor; Colonic Neoplasms; Cytokines; Drug Evaluation, Preclinical; Female; Glutathione; Losartan; Mice; Myocardium; Neoplasm Transplantation; Tumor Burden; Ventricular Remodeling | 2015 |
Cardiovascular and single-unit responses to microinjection of angiotensin II into the bed nucleus of the stria terminalis in rat.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Heart Rate; Losartan; Male; Microelectrodes; Microinjections; Neurons; Rats, Wistar; Receptor, Angiotensin, Type 1; Septal Nuclei; Vasoconstrictor Agents | 2015 |
Angiotensin II-induced hypertensive renal inflammation is mediated through HMGB1-TLR4 signaling in rat tubulo-epithelial cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Cell Line; Epithelial Cells; HMGB1 Protein; Hypertension; Kidney Failure, Chronic; Kidney Tubules; Losartan; NF-kappa B; Rats; Signal Transduction; Toll-Like Receptor 4 | 2015 |
TRIF promotes angiotensin II-induced cross-talk between fibroblasts and macrophages in atrial fibrosis.
Topics: Adaptor Proteins, Vesicular Transport; Angiotensin II; Animals; Atrial Fibrillation; Cell Communication; Cell Proliferation; Chemotaxis; Fibroblasts; Fibrosis; Gene Expression Regulation; Heart Atria; Humans; Losartan; Macrophages; Mice; Mice, Inbred C57BL; RNA, Small Interfering; Signal Transduction | 2015 |
The angiotensin receptor blocker losartan reduces coronary arteriole remodeling in type 2 diabetic mice.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arterioles; Blood Pressure; Coronary Vessels; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hypertension; Losartan; Male; Mice; Microvessels; Muscle, Smooth, Vascular; Pilot Projects; Receptor, Angiotensin, Type 1; Renin-Angiotensin System | 2016 |
Losartan: A new treatment for cardiac cachexia?
Topics: Angiotensin II; Blood Pressure; Cachexia; Humans; Losartan; Myocardium; Neoplasms | 2015 |
Th-17 cell activation in response to high salt following acute kidney injury is associated with progressive fibrosis and attenuated by AT-1R antagonism.
Topics: Acute Kidney Injury; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cells, Cultured; Cytoprotection; Disease Models, Animal; Disease Progression; Fibrosis; Kidney; Losartan; Lymphocyte Activation; Male; Nephrectomy; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Renin-Angiotensin System; Sodium Chloride, Dietary; Th17 Cells; Time Factors | 2015 |
Angiotensin and mineralocorticoid receptor antagonism attenuates cardiac oxidative stress in angiotensin II-infused rats.
Topics: Adrenal Glands; Aldehydes; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biomarkers; Blood Pressure; Disease Models, Animal; Drug Therapy, Combination; Eplerenone; Heart Diseases; Hypertension; Lipid Peroxidation; Losartan; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Oxidative Stress; Rats, Sprague-Dawley; Renin-Angiotensin System; Signal Transduction; Spironolactone; Time Factors; Tyrosine | 2015 |
[Blockade of AT1 receptor of Angiotensin II reduces the number of antral follicles in female rats with obesity induced by cafeteria diet].
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Diet; Energy Intake; Female; Food Services; Losartan; Obesity; Ovarian Follicle; Random Allocation; Rats; Rats, Wistar | 2015 |
Exploiting AT2R to Improve CD117 Stem Cell Function In Vitro and In Vivo--Perspectives for Cardiac Stem Cell Therapy.
Topics: Angiotensin II; Animals; Cell Line; Cell- and Tissue-Based Therapy; Coculture Techniques; Losartan; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Proto-Oncogene Proteins c-kit; Receptor, Angiotensin, Type 2; Stem Cells | 2015 |
AT1 receptor blocker losartan protects against mechanical ventilation-induced diaphragmatic dysfunction.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Diaphragm; Enalapril; Female; Losartan; Muscle Weakness; Rats; Rats, Sprague-Dawley; Respiration, Artificial | 2015 |
Angiotensin-(1-7) enhances the effects of angiotensin II on the cardiac sympathetic afferent reflex and sympathetic activity in rostral ventrolateral medulla in renovascular hypertensive rats.
Topics: Analysis of Variance; Angiotensin I; Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; Drug Interactions; Hypertension, Renovascular; Losartan; Male; Medulla Oblongata; Peptide Fragments; Random Allocation; Rats; Rats, Sprague-Dawley; Reflex; Sympathetic Nervous System; Treatment Outcome | 2015 |
Effects of angiotensin II on leptin and downstream leptin signaling in the carotid body during acute intermittent hypoxia.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Captopril; Carotid Body; Hypoxia, Brain; Leptin; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Receptors, Leptin; Signal Transduction | 2015 |
Multivalent nanoparticles bind the retinal and choroidal vasculature.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Binding, Competitive; Calcium Signaling; Capillaries; Choroid; Drug Carriers; HeLa Cells; Humans; Injections, Intravenous; Losartan; Mice; Protein Binding; Quantum Dots; Receptor, Angiotensin, Type 1; Retinal Vessels; Surface Properties; Tissue Distribution | 2015 |
Renal oxidative stress and renal CD8(+) T-cell infiltration in mercuric chloride-induced nephropathy in rats: role of angiotensin II.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Catalase; CD8-Positive T-Lymphocytes; Enalapril; Glutathione; Kidney; Kidney Diseases; Losartan; Male; Malondialdehyde; Mercuric Chloride; Necrosis; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2016 |
Ets-1 upregulation mediates angiotensin II-related cardiac fibrosis.
Topics: Angiotensin II; Animals; Cell Proliferation; Collagen; Connective Tissue Growth Factor; Dose-Response Relationship, Drug; Fibroblasts; Fibrosis; Heart; Losartan; Male; Myocardium; Plasminogen Activator Inhibitor 1; Proto-Oncogene Protein c-ets-1; Rats; Rats, Sprague-Dawley; Up-Regulation | 2015 |
Cross talk between AT1 receptors and Toll-like receptor 4 in microglia contributes to angiotensin II-derived ROS production in the hypothalamic paraventricular nucleus.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Bacterial Agents; Immunity, Innate; Inflammation; Losartan; Male; Mice; Mice, Inbred C3H; Mice, Knockout; Microglia; Minocycline; Oxidative Stress; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Toll-Like Receptor 4 | 2016 |
Sympathoexcitation in Rats With Chronic Heart Failure Depends on Homeobox D10 and MicroRNA-7b Inhibiting GABBR1 Translation in Paraventricular Nucleus.
Topics: 3' Untranslated Regions; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Binding Sites; Chronic Disease; Disease Models, Animal; Gene Expression Regulation; Heart Failure; HEK293 Cells; Homeodomain Proteins; Humans; Losartan; Male; Mice; MicroRNAs; Oligonucleotides, Antisense; Paraventricular Hypothalamic Nucleus; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, GABA-B; RNA Interference; Sympathetic Nervous System; Transcription Factors; Transfection | 2016 |
May the fibrosis be with you: Is discoidin domain receptor 2 the receptor we have been looking for?
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Collagen; Discoidin Domain Receptors; Fibroblasts; Fibrosis; Gene Expression Regulation; Humans; Losartan; Myocardium; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Receptor Protein-Tyrosine Kinases; Receptors, Mitogen; Signal Transduction | 2016 |
[Intervention Mechanism of Extracts from Radix Ginseng, Radix Notoginseng and Rhizoma Chuanxiong on Adventitia of Senescent Rats].
Topics: Adventitia; Aging; Angiotensin II; Animals; Aorta, Thoracic; Drugs, Chinese Herbal; Losartan; Panax; Plant Roots; Rats; Rats, Wistar; Renin-Angiotensin System; Rhizome; RNA, Messenger | 2015 |
Renovascular remodeling and renal injury after extended angiotensin II infusion.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Glomerular Filtration Rate; Kidney; Losartan; Male; Natriuresis; Rats; Rats, Wistar; Renal Circulation; Vascular Remodeling; Vascular Resistance | 2016 |
The renin-angiotensin system and its vasoactive metabolite angiotensin-(1-7) in the mechanism of the healing of preexisting gastric ulcers. The involvement of Mas receptors, nitric oxide, prostaglandins and proinflammatory cytokines.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Cytokines; Enzyme Inhibitors; Gastric Mucosa; Imidazoles; Indomethacin; Interleukin-1beta; Lisinopril; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Prostaglandins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Renin-Angiotensin System; Stomach Ulcer; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2016 |
Histamine H3 Receptor Agonist Imetit Attenuated Isoproterenol Induced Renin Angiotensin System and Sympathetic Nervous System Overactivity in Myocardial Infarction of Rats.
Topics: Angiotensin II; Animals; Antioxidants; Cardiotonic Agents; Histamine Agonists; Histamine H3 Antagonists; Imidazoles; Isoproterenol; Losartan; Male; Myocardial Infarction; Myocardium; Norepinephrine; Piperidines; Rats; Renin-Angiotensin System; Sympathetic Nervous System; Thiourea | 2016 |
Effect of angiotensin II type 1 receptor blocker on 12-lipoxygenase activity and slit diaphragm protein expression in type 2 diabetic rat glomeruli.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arachidonate 12-Lipoxygenase; Cadherins; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diet, High-Fat; Kidney Glomerulus; Lipoxygenase Inhibitors; Losartan; Male; Membrane Proteins; Mice; Podocytes; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Streptozocin | 2016 |
Role of Mas receptor antagonist (A779) in renal hemodynamics in condition of blocked angiotensin II receptors in rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Female; Hemodynamics; Imidazoles; Kidney; Losartan; Male; Organ Size; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pyridines; Rats; Rats, Wistar; Receptor Cross-Talk; Receptors, Angiotensin; Receptors, G-Protein-Coupled; Regional Blood Flow | 2016 |
Angiotensin II Modulates p130Cas of Podocytes by the Suppression of AMP-Activated Protein Kinase.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blotting, Western; Cell Line; Cell Nucleus; Crk-Associated Substrate Protein; Cytoplasm; Focal Adhesion Kinase 1; Losartan; Metformin; Mice; Microscopy, Confocal; Podocytes; Protein Kinase Inhibitors; Ribonucleotides; Signal Transduction | 2016 |
Application of vasoactive and matrix-modifying drugs can improve polyplex delivery to tumors upon intravenous administration.
Topics: Administration, Intravenous; Angiotensin II; Animals; Cell Line, Tumor; Collagen Type I; DNA; Drug Delivery Systems; Female; Gene Expression Regulation, Neoplastic; Gene Transfer Techniques; Green Fluorescent Proteins; Losartan; Luciferases, Firefly; Melanoma, Experimental; Mice, Inbred C57BL; Mice, Inbred DBA; Nanoparticles; Nitroglycerin; Oligopeptides; Polyethylene Glycols; Polyethyleneimine; Receptor, Melanocortin, Type 1; Regional Blood Flow; Vasoconstrictor Agents; Vasodilator Agents | 2016 |
Angiotensin II regulation of angiotensin-converting enzymes in spontaneously hypertensive rat primary astrocyte cultures.
Topics: Angiotensin II; Animals; Anti-Arrhythmia Agents; Astrocytes; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Losartan; Peptidyl-Dipeptidase A; Pregnancy; Rats; Rats, Inbred SHR; Rats, Wistar; RNA, Messenger; Time Factors | 2016 |
Retinol-Binding Protein 4 Induces Cardiomyocyte Hypertrophy by Activating TLR4/MyD88 Pathway.
Topics: Adipocytes; Angiotensin II; Animals; Blotting, Western; Cardiomegaly; Cells, Cultured; Inflammation; Losartan; Male; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; Myocytes, Cardiac; Oxidative Stress; Polymerase Chain Reaction; Reactive Oxygen Species; Retinol-Binding Proteins, Plasma; Signal Transduction; Toll-Like Receptor 4 | 2016 |
Whey peptide Isoleucine-Tryptophan inhibits expression and activity of matrix metalloproteinase-2 in rat aorta.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Dipeptides; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Humans; Hypertension; Losartan; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Rats; Renin-Angiotensin System; Vascular Stiffness; Whey Proteins | 2016 |
Activation of the Renin-Angiotensin System Promotes Colitis Development.
Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Colitis; Colon; Epithelial Cells; Fumarates; Humans; Hydralazine; Inflammatory Bowel Diseases; Losartan; Mice; Mice, Transgenic; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System; Th17 Cells | 2016 |
Renal denervation significantly attenuates cardiorenal fibrosis in rats with sustained pressure overload.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biomarkers; Cardiomyopathies; Disease Models, Animal; Fibrosis; Heart Atria; Heart Ventricles; Humans; Kidney; Losartan; Myocardium; Natriuretic Peptide, Brain; Peptide Fragments; Procollagen; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Sympathectomy | 2016 |
Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Losartan; Pyridines; Rats; Receptors, Angiotensin | 2016 |
Angiotensin II increases sperm phagocytosis by neutrophils in vitro: A possible physiological role in the bovine oviduct.
Topics: Angiotensin II; Animals; Cattle; Epithelial Cells; Extracellular Traps; Female; Losartan; Male; Neutrophils; Oviducts; Peptidyl-Dipeptidase A; Phagocytosis; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Spermatozoa; Superoxides | 2016 |
Protective effects of MCR-1329, a dual α1 and angII receptor antagonist, in mineralocorticoid-induced hypertension.
Topics: Adrenergic alpha-1 Receptor Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Chromones; Desoxycorticosterone Acetate; Endothelium, Vascular; Hypertension; Losartan; Male; Mineralocorticoids; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Prazosin; Protective Agents; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptors, Angiotensin; Signal Transduction; Vasoconstriction | 2016 |
Uric acid stimulates proliferative pathways in vascular smooth muscle cells through the activation of p38 MAPK, p44/42 MAPK and PDGFRβ.
Topics: Angiotensin II; Animals; Atherosclerosis; Cardiovascular Diseases; Cell Proliferation; Gene Expression Regulation; Humans; Hypertension; Hyperuricemia; Losartan; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Receptor, Angiotensin, Type 1; Receptor, Platelet-Derived Growth Factor beta; Uric Acid | 2017 |
Angiotensin II induces interleukin-6 expression in astrocytes: Role of reactive oxygen species and NF-κB.
Topics: Angiotensin II; Animals; Astrocytes; Brain; Female; Gene Expression Regulation; Hydrazones; Imidazoles; Interleukin-6; Losartan; NF-kappa B; Nitroimidazoles; Pyridines; Rats, Inbred SHR; Rats, Wistar; Reactive Oxygen Species; RNA, Messenger; Time Factors | 2016 |
Facilitation by the renin-angiotensin system of cyclosporine-evoked hypertension in rats: Role of arterial baroreflexes and vasoreactivity.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Angiotensin II; Animals; Aorta; Atrasentan; Baroreflex; Blood Pressure; Captopril; Cyclosporine; Hypertension; Indomethacin; Losartan; Male; Naphthalenes; Nitric Oxide Synthase Type III; Nitroprusside; Oligopeptides; Phenylephrine; Piperidines; Propionates; Pyrrolidines; Rats; Renin-Angiotensin System; Vasoconstriction; Vasodilation | 2016 |
Sex differences in angiotensin II responses contribute to a differential regulation of cox-mediated vascular dysfunction during aging.
Topics: Aging; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cyclooxygenase 2; Endothelium, Vascular; Female; Indomethacin; Losartan; Male; Mice; Oxidative Stress; Prostaglandins; Renin-Angiotensin System; Sex Factors; Vasodilation | 2016 |
Changes in cardiovascular responses to chemoreflex activation of rats recovered from protein restriction are not related to AT
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arterial Pressure; Bradycardia; Cardiovascular System; Chemoreceptor Cells; Diet, Protein-Restricted; Heart Rate; Losartan; Male; Rats; Rats, Inbred F344; Receptor, Angiotensin, Type 1; Reflex; Tachycardia; Tidal Volume | 2017 |
The role of brain angiotensin II (type 2) receptors and nitric oxide in the renal sympathoinhibitory response to acute volume expansion in conscious rats.
Topics: Administration, Intravenous; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Arterial Pressure; Body Fluids; Brain; Enzyme Inhibitors; Heart Rate; Imidazoles; Infusions, Intraventricular; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oligopeptides; Pyridines; Rats; Receptor, Angiotensin, Type 2; Sodium Chloride; Sympathetic Nervous System | 2017 |
Chronic blockade of the AT2 receptor with PD123319 impairs insulin signaling in C57BL/6 mice.
Topics: Adiponectin; Adipose Tissue; Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Chemokine CCL2; Diabetes Mellitus, Type 2; Humans; Hypertension; Imidazoles; Insulin; Insulin Resistance; Interleukin-6; Losartan; Mice; Mice, Knockout; Pyridines; Receptor, Angiotensin, Type 2; Signal Transduction; Tumor Necrosis Factor-alpha | 2017 |
Impaired Aortic Contractility to Uridine Adenosine Tetraphosphate in Angiotensin II-Induced Hypertensive Mice: Receptor Desensitization?
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Arterial Pressure; Blood Pressure; Dinucleoside Phosphates; Hypertension; Isometric Contraction; Losartan; Male; Mice; Mice, Inbred C57BL; Myocardial Contraction; Receptor, Angiotensin, Type 1; Receptors, Purinergic P2X1; Vasoconstrictor Agents | 2017 |
Anti-Fibrotic Effect of Losartan, an Angiotensin II Receptor Blocker, Is Mediated through Inhibition of ER Stress via Up-Regulation of SIRT1, Followed by Induction of HO-1 and Thioredoxin.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Epithelial Cells; Gene Expression; Heme Oxygenase-1; Kidney Diseases; Losartan; Mice; Sirtuin 1; Thioredoxins; Transforming Growth Factor beta; Tunicamycin | 2017 |
Early treatment with losartan effectively ameliorates hypertension and improves vascular remodeling and function in a prehypertensive rat model.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; Gene Expression Regulation; Hypertension; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Vascular Remodeling | 2017 |
miR-181b regulates vascular stiffness age dependently in part by regulating TGF-β signaling.
Topics: Aging; Angiotensin II; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Cardiovascular Diseases; Endothelial Cells; Extracellular Matrix; Hypertension; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Nitric Oxide; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta; Vascular Stiffness | 2017 |
The asymmetric dimethylarginine-mediated inhibition of nitric oxide in the rostral ventrolateral medulla contributes to regulation of blood pressure in hypertensive rats.
Topics: Amidohydrolases; Angiotensin II; Animals; Arginine; Blood Pressure; Heart Rate; Kidney; Losartan; Male; Medulla Oblongata; Nitric Oxide; omega-N-Methylarginine; Protein-Arginine N-Methyltransferases; Rats, Inbred WKY; Rats, Sprague-Dawley; Sympathetic Nervous System | 2017 |
Inhibitory effects of losartan and azelnidipine on augmentation of blood pressure variability induced by angiotensin II in rats.
Topics: Angiotensin II; Animals; Azetidinecarboxylic Acid; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Hypertension; Losartan; Male; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Time Factors | 2017 |
The ACE-2/Ang1-7/Mas cascade enhances bone structure and metabolism following angiotensin-II type 1 receptor blockade.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Female; Femur; Losartan; Minerals; Peptide Fragments; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Renin-Angiotensin System | 2017 |
Thymoquinone ameliorates renal damage in unilateral ureteral obstruction in rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzoquinones; Biomarkers; Captopril; Chemokine CCL2; Gene Expression Regulation; Kidney; Kidney Diseases; Losartan; Male; Oxidative Stress; Rats; Rats, Wistar; Sulfhydryl Compounds; Ureteral Obstruction | 2017 |
Angiotensin II induces calcium/calcineurin signaling and podocyte injury by downregulating microRNA-30 family members.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Calcineurin; Calcium; Calcium Signaling; Cells, Cultured; Down-Regulation; Humans; Hypertension; Kidney Diseases; Kidney Glomerulus; Losartan; Male; Mice, Inbred C57BL; MicroRNAs; Podocytes | 2017 |
Role of RAS/Wnt/β-catenin axis activation in the pathogenesis of podocyte injury and tubulo-interstitial nephropathy.
Topics: Angiotensin II; beta Catenin; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Kidney Tubules; Losartan; Nephritis, Interstitial; Podocytes; Pyrimidinones; Renin-Angiotensin System; Structure-Activity Relationship; Wnt Proteins | 2017 |
Losartan reverses COX-2-dependent vascular dysfunction in offspring of hyperglycaemic rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cyclooxygenase 2; Endothelium, Vascular; Female; Hyperglycemia; Losartan; Male; Mesenteric Arteries; Pregnancy; Rats; Rats, Wistar; Vasoconstriction; Vasodilation | 2017 |
Effect of uric acid on inflammatory COX-2 and ROS pathways in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Cyclooxygenase 2; Disease Models, Animal; Humans; Hypertension; Inflammation; Losartan; Muscle, Smooth, Vascular; Proto-Oncogene Proteins; Rats; Reactive Oxygen Species; Receptor Protein-Tyrosine Kinases; Signal Transduction; Superoxides; Uric Acid | 2017 |
Enhanced hemodynamic responses to angiotensin II in diabetes are associated with increased expression and activity of AT1 receptors in the afferent arteriole.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arterial Pressure; Arterioles; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Losartan; Male; Mice, Inbred BALB C; Perfusion; Receptor, Angiotensin, Type 1; Vasoconstriction | 2017 |
Periostin cross‑reacts with the renin‑angiotensin system during liver fibrosis development.
Topics: Angiotensin II; Animals; Cell Adhesion Molecules; Collagen Type I; Collagen Type I, alpha 1 Chain; Gene Expression Regulation; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Losartan; Rats; Renin-Angiotensin System; Signal Transduction; Transforming Growth Factor beta1 | 2017 |
Angiotensin AT1 receptors modulate the anxiogenic effects of angiotensin (5-8) injected into the rat ventrolateral periaqueductal gray.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Anxiety; Imidazoles; Losartan; Male; Periaqueductal Gray; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1 | 2017 |
Losartan counteracts the effects of cardiomyocyte swelling on glucose uptake and insulin receptor substrate-1 levels.
Topics: Angiotensin II; Animals; Cell Line; Flow Cytometry; Glucose; Insulin Receptor Substrate Proteins; Losartan; Myocytes, Cardiac; Rats | 2017 |
Intrarenal Mas and AT
Topics: Anesthesia, General; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Diet, Sodium-Restricted; Glomerular Filtration Rate; Hemodynamics; Infusions, Parenteral; Kidney; Losartan; Male; Natriuresis; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Renal Circulation; Renal Elimination; Renin-Angiotensin System; Signal Transduction; Sodium, Dietary | 2017 |
Angiotensin receptor signaling and prostate tumor growth in mice.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Line, Tumor; Losartan; Male; Mice; Neoplasm Transplantation; Prostatic Neoplasms; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Signal Transduction; Transcriptome; Tumor Burden; Vasoconstrictor Agents | 2017 |
Inhibition of angiotensin II and calpain attenuates pleural fibrosis.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Bleomycin; Calpain; Carbon; Cell Line; Collagen Type I; Dipeptides; Disease Models, Animal; Fibrosis; Humans; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pleural Diseases | 2018 |
Angiotensin II Causes Neuronal Damage in Stretch-Injured Neurons: Protective Effects of Losartan, an Angiotensin T
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Caspase 3; Cytokines; Enzyme Activation; Inflammation Mediators; Losartan; Neurons; Neuroprotective Agents; Oxidative Stress; Peptidyl-Dipeptidase A; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Stress, Mechanical; Up-Regulation | 2018 |
KLF 15 Works as an Early Anti-Fibrotic Transcriptional Regulator in Ang II-Induced Renal Fibrosis via Down-Regulation of CTGF Expression.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Connective Tissue Growth Factor; DNA-Binding Proteins; Fibrosis; Gene Expression Regulation; Kruppel-Like Transcription Factors; Losartan; Mice; Promoter Regions, Genetic; Rats; Receptor, Angiotensin, Type 1; Transcription Factors | 2017 |
Losartan suppresses the kainate-induced changes of angiotensin AT
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensins; Animals; Blood Pressure; Comorbidity; Disease Models, Animal; Epilepsy; Gene Expression; Hippocampus; Hypertension; Kainic Acid; Limbic System; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System | 2018 |
Direct renin inhibition is not enough to prevent reactive oxygen species generation and vascular dysfunction in renovascular hypertension.
Topics: Amides; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta; Drug Synergism; Fumarates; Hypertension, Renovascular; Losartan; Male; Nitrites; Oxidative Stress; Rats; Reactive Oxygen Species; Relaxation; Renin | 2018 |
The enhancement of serotonin-induced contraction of rat femoral artery is mediated by angiotensin II release from intact endothelium.
Topics: Angiotensin II; Animals; Blood Glucose; Body Weight; Endothelium, Vascular; Femoral Artery; Losartan; Rats; Rats, Wistar; Serotonin; Vasoconstriction | 2019 |
Angiotensin II facilitates GABAergic neurotransmission at postsynaptic sites in rat amygdala neurons.
Topics: Amygdala; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Bicuculline; Electric Stimulation; Excitatory Amino Acid Agents; GABA Antagonists; GABAergic Neurons; gamma-Aminobutyric Acid; Imidazoles; In Vitro Techniques; Losartan; Male; Mice; Neurotransmitter Agents; Patch-Clamp Techniques; Pyridines; Rats; Rats, Sprague-Dawley; Synaptic Potentials; Vasoconstrictor Agents | 2018 |
Angiotensin II Regulates Th1 T Cell Differentiation Through Angiotensin II Type 1 Receptor-PKA-Mediated Activation of Proteasome.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Bortezomib; Cell Differentiation; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dual Specificity Phosphatase 1; Humans; Interferon-gamma; Interleukin-2; Isoquinolines; Jurkat Cells; Losartan; Proteasome Endopeptidase Complex; Protein Subunits; Receptor, Angiotensin, Type 1; Signal Transduction; STAT1 Transcription Factor; Sulfonamides; T-Lymphocytes; Ubiquitination | 2018 |
AT2R (Angiotensin II Type 2 Receptor)-Mediated Regulation of NCC (Na-Cl Cotransporter) and Renal K Excretion Depends on the K Channel, Kir4.1.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Imidazoles; Ion Transport; Kidney Tubules, Distal; Losartan; Mice; Mice, Knockout; Potassium Channels, Inwardly Rectifying; Pyridines; Receptor, Angiotensin, Type 2; Sodium Chloride Symporter Inhibitors; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 3; Water-Electrolyte Imbalance | 2018 |
Acetone fraction from Sechium edule (Jacq.) S.w. edible roots exhibits anti-endothelial dysfunction activity.
Topics: Acetone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Cinnamates; Cucurbitaceae; Disease Models, Animal; Endothelium, Vascular; Fatty Acids; Female; Losartan; Mexico; Mice; Mice, Inbred C57BL; Plant Extracts; Plant Roots; Vascular Diseases | 2018 |
Antidepressant-like effect of losartan involves TRKB transactivation from angiotensin receptor type 2 (AGTR2) and recruitment of FYN.
Topics: Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Antidepressive Agents; Captopril; Carbazoles; Cells, Cultured; Cerebral Cortex; Enalapril; Hippocampus; Imidazoles; Immobility Response, Tonic; Indole Alkaloids; Losartan; Male; Mice; Microinjections; Prefrontal Cortex; Proto-Oncogene Proteins c-fyn; Pyridines; Rats; Receptor, Angiotensin, Type 2; Receptor, trkB; Transcriptional Activation | 2018 |
Effects and Mechanism of SO2 Inhalation on Rat Myocardial Collagen Fibers.
Topics: Angiotensin II; Animals; Blood Pressure; Body Weights and Measures; Collagen; Heart; Heart Ventricles; Hydroxyproline; Hypertension; Losartan; Male; Myocardium; Myocytes, Cardiac; Rats; Sulfur Dioxide; Ventricular Remodeling | 2018 |
Angiotensin II increases angiogenesis by NF-κB-mediated transcriptional activation of angiogenic factor AGGF1.
Topics: Angiogenesis Inducing Agents; Angiogenic Proteins; Angiotensin II; Gene Expression Regulation; Humans; Imidazoles; Losartan; Neovascularization, Pathologic; NF-kappa B; Proto-Oncogene Mas; Pyridines; Receptor, Angiotensin, Type 1; Transcription Factor RelA; Transcriptional Activation | 2018 |
Transdermal Delivery of AT1 Receptor Antagonists Reduce Blood Pressure and Reveal a Vasodilatory Effect on Kidney Blood Vessels.
Topics: Administration, Cutaneous; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Blood Vessels; Humans; Kidney; Losartan; Male; Oligopeptides; Rabbits; Rats, Wistar; Receptor, Angiotensin, Type 1; Reproducibility of Results; Skin Absorption; Valsartan; Vasodilation | 2018 |
Angiotensin II aggravates lipopolysaccharide induced human pulmonary microvascular endothelial cells permeability in high glucose status.
Topics: Actins; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Apoptosis; Capillary Permeability; Cytoskeleton; Endothelial Cells; Glucose; Humans; Lipopolysaccharides; Losartan; Lung; Tumor Necrosis Factor-alpha | 2018 |
Critical role of angiotensin II type 2 receptors in the control of mitochondrial and cardiac function in angiotensin II-preconditioned rat hearts.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Heart; Losartan; Male; Mitochondria; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Signal Transduction | 2018 |
The angiotensin II type I receptor antagonist losartan retards amygdala kindling-induced epileptogenesis.
Topics: Amygdala; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Brain Injuries; Cerebral Cortex; Epilepsy; Kindling, Neurologic; Losartan; Male; Rats, Wistar; Receptor, Angiotensin, Type 1 | 2018 |
Nigella sativa extract is a potent therapeutic agent for renal inflammation, apoptosis, and oxidative stress in a rat model of unilateral ureteral obstruction.
Topics: Angiotensin II; Animals; Apoptosis; Captopril; Chemokine CCL2; Creatinine; Fibrosis; Inflammation; Kidney; Kidney Diseases; Losartan; Male; Malondialdehyde; Nigella sativa; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar; Renin-Angiotensin System; Tumor Necrosis Factor-alpha; Urea; Ureteral Obstruction | 2018 |
Involvement of hippocampal angiotensin 1 receptors in anxiety-like behaviour of olfactory bulbectomized rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Anxiety; CA1 Region, Hippocampal; Losartan; Male; Maze Learning; Microinjections; Olfactory Bulb; Rats; Receptor, Angiotensin, Type 1 | 2018 |
The angiotensin II/AT1 receptor pathway mediates malaria-induced acute kidney injury.
Topics: Acute Kidney Injury; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Disease Models, Animal; Kidney; Losartan; Malaria; Male; Mice, Inbred C57BL; Plasmodium berghei; Random Allocation; Receptor, Angiotensin, Type 1 | 2018 |
Cathepsin B-Mediated NLRP3 Inflammasome Formation and Activation in Angiotensin II -Induced Hypertensive Mice: Role of Macrophage Digestion Dysfunction.
Topics: Angiotensin II; Animals; Cathepsin B; Cell Line; Cell Membrane Permeability; Chalcones; Escherichia coli; Hypertension; Inflammasomes; Losartan; Lysosomes; Macrophages; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; NLR Family, Pyrin Domain-Containing 3 Protein; Phagocytosis; RNA Interference; RNA, Small Interfering | 2018 |
A novel role of angiotensin II in epidermal cell lineage determination: Angiotensin II promotes the differentiation of mesenchymal stem cells into keratinocytes through the p38 MAPK, JNK and JAK2 signalling pathways.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Anthracenes; Bone Marrow Cells; Cell Differentiation; Cell Lineage; Cell Movement; Imidazoles; Janus Kinase 2; Janus Kinases; Keratinocytes; Losartan; Male; MAP Kinase Signaling System; Mesenchymal Stem Cells; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tyrphostins | 2019 |
Angiotensin II confers resistance to apoptosis in cardiac myofibroblasts through the AT1/ERK1/2/RSK1 pathway.
Topics: Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Apoptosis; Butadienes; Cell Survival; Cycloheximide; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Losartan; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardium; Myofibroblasts; Nitriles; Primary Cell Culture; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Ribosomal Protein S6 Kinases, 90-kDa; RNA, Small Interfering; Signal Transduction; Tumor Necrosis Factor-alpha | 2019 |
Losartan prevents the elevation of blood pressure in adipose-PRR deficient female mice while elevated circulating sPRR activates the renin-angiotensin system.
Topics: Adipose Tissue; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Antihypertensive Agents; Blood Pressure; Female; Kidney; Liver; Losartan; Mice; Mice, Inbred C57BL; Prorenin Receptor; Receptors, Cell Surface; Renin-Angiotensin System; Vasopressins | 2019 |
Cerebral and skeletal muscle feed artery vasoconstrictor responses in a mouse model with greater large elastic artery stiffness.
Topics: Angiotensin II; Animals; Cerebral Arteries; Disease Models, Animal; Endothelin-1; Endothelium, Vascular; Losartan; Male; Mice; Muscle, Skeletal; Norepinephrine; Receptor, Angiotensin, Type 1; Vascular Stiffness; Vasoconstriction; Vasoconstrictor Agents | 2019 |
Estradiol modulation of the renin-angiotensin system and the regulation of fear extinction.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Brain; Contraceptives, Oral, Synthetic; Estradiol; Extinction, Psychological; Fear; Female; Hippocampus; Levonorgestrel; Losartan; Memory Consolidation; Ovariectomy; Pituitary Gland; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System | 2019 |
Analysis of angiotensin II-Induced rat urinary bladder contractions in the presence of angiotensin II receptors blockers.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Homeostasis; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Wistar; Stress, Mechanical; Urinary Bladder | 2021 |
Pathogenic role of angiotensin II and the NF-κB system in a model of malignant hypertensive nephrosclerosis.
Topics: Albuminuria; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arterioles; Female; Glomerulosclerosis, Focal Segmental; Hypertension, Renal; Kidney Cortex; Kidney Glomerulus; Lactation; Losartan; Male; Nephrectomy; Nephritis; Nephrosclerosis; NF-kappa B; Pyrrolidines; Rats; Rats, Wistar; Thiocarbamates | 2019 |
Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT
Topics: Angiotensin II; Animals; Binding Sites; CHO Cells; Cricetulus; Endothelin-1; Fluorescence Resonance Energy Transfer; Humans; Isoxazoles; Ligands; Losartan; Peptides, Cyclic; Protein Aggregates; Receptor, Endothelin A; Thiophenes | 2019 |
Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates renal (pro) renin receptor expression in Npr1 null mutant mice.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Cyclic GMP; Female; Kidney; Losartan; Male; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Mitogen-Activated Protein Kinases; Peptidyl-Dipeptidase A; Prorenin Receptor; Receptor, Angiotensin, Type 1; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface | 2019 |
Angiotensin II Induces Automatic Activity of the Isolated Guinea Pig Pulmonary Vein Myocardium through Activation of the IP₃ Receptor and the Na⁺-Ca
Topics: Action Potentials; Angiotensin II; Aniline Compounds; Animals; Guinea Pigs; Inositol 1,4,5-Trisphosphate Receptors; Losartan; Male; Myocardial Contraction; Myocardium; Myocytes, Cardiac; Phenyl Ethers; Pulmonary Veins; Swine | 2019 |
Blood pressure lowering effect of Ficus deltoidea var kunstleri in spontaneously hypertensive rats: possible involvement of renin-angiotensin-aldosterone system, endothelial function and anti-oxidant system.
Topics: Angiotensin II; Animals; Antioxidants; Blood Pressure; Captopril; Disease Models, Animal; Drugs, Chinese Herbal; Ficus; Hypertension; Losartan; Male; Nitric Oxide Synthase Type III; Peptidyl-Dipeptidase A; Plant Extracts; Rats; Rats, Inbred SHR; Renin-Angiotensin System | 2019 |
Angiotensin II triggers autophagy and apoptosis in PC12 cell line: An in vitro Alzheimer's disease model.
Topics: Alzheimer Disease; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Autophagy; Imidazoles; Losartan; Models, Biological; Neurodegenerative Diseases; PC12 Cells; Pyridines; Rats; Receptor, Angiotensin, Type 1 | 2019 |
Angiotensin II-mediated MYH9 downregulation causes structural and functional podocyte injury in diabetic kidney disease.
Topics: Acetylcysteine; Actin Cytoskeleton; Angiotensin II; Animals; Calcium; Cell Adhesion; Cell Line, Transformed; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Down-Regulation; Humans; Losartan; Mice; Mice, Inbred C57BL; Microfilament Proteins; Molecular Motor Proteins; Myosin Heavy Chains; NADPH Oxidase 4; Podocytes; Rats; Rats, Inbred Strains; Reactive Oxygen Species; Receptors, Leptin; RNA Interference; TRPC6 Cation Channel | 2019 |
The role of monocyte chemotactic protein-induced protein 1 (MCPIP1) in angiotensin II-induced macrophage apoptosis and vulnerable plaque formation.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Disease Models, Animal; Endoplasmic Reticulum Stress; Losartan; Macrophages, Peritoneal; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; Plaque, Atherosclerotic; RAW 264.7 Cells; Receptor, Angiotensin, Type 1; Ribonucleases; RNA, Small Interfering | 2019 |
Role of sodium/glucose cotransporter inhibition on a rat model of angiotensin II-dependent kidney damage.
Topics: Acute Kidney Injury; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzhydryl Compounds; Blood Pressure; Disease Models, Animal; Glomerular Filtration Rate; Glucose; Glucosides; Hypertension; Losartan; Male; Microvilli; Proteinuria; Rats; Rats, Wistar; Reactive Oxygen Species; RNA, Messenger; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2019 |
Administration of losartan preserves cardiomyocyte size and prevents myocardial dysfunction in tail-suspended mice by inhibiting p47
Topics: Angiotensin II; Animals; Apelin; Apelin Receptors; ATPases Associated with Diverse Cellular Activities; Blood Pressure; Cell Size; Diastole; DNA Helicases; Enzyme Activation; Hindlimb Suspension; Losartan; Male; Mice; Muscle Proteins; Myocardium; Myocytes, Cardiac; Organ Size; Oxidative Stress; Phosphorylation; Tripartite Motif Proteins; Ubiquitin-Protein Ligases; Valsartan | 2019 |
Methylation-reprogrammed AGTR1 results in increased vasoconstriction by angiotensin II in human umbilical cord vessel following in vitro fertilization-embryo transfer.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Antihypertensive Agents; DNA Methylation; Embryo Transfer; Female; Fertilization in Vitro; Humans; Imidazoles; Losartan; Pregnancy; Pyridines; Receptor, Angiotensin, Type 1; Umbilical Cord; Vasoconstriction; Vasoconstrictor Agents | 2019 |
Interleukin enhancement binding factor 3 inhibits cardiac hypertrophy by targeting asymmetric dimethylarginine-nitric oxide.
Topics: Amidohydrolases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arginine; Cardiomegaly; Down-Regulation; Gene Knockdown Techniques; Losartan; Male; Myocytes, Cardiac; Nitric Oxide; Nuclear Factor 90 Proteins; Rats, Sprague-Dawley | 2019 |
Losartan through Hsp70 Avoids Angiotensin II Induced Mesenchymal Epithelial Transition in Proximal Tubule Cells from Spontaneously Hypertensive Rats.
Topics: Actin Cytoskeleton; Angiotensin II; Animals; Cadherins; Cell Movement; Cells, Cultured; Epithelial-Mesenchymal Transition; Focal Adhesions; Gene Expression Regulation; HSP70 Heat-Shock Proteins; Kidney Tubules, Proximal; Losartan; Male; Matrix Metalloproteinase 2; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA Interference; RNA, Small Interfering; Vinculin | 2019 |
Tactile stimulation of adult rats modulates hormonal responses, depression-like behaviors, and memory impairment induced by chronic mild stress: Role of angiotensin II.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Behavior, Animal; Cognitive Dysfunction; Depression; Handling, Psychological; Hypothalamus; Losartan; Memory Disorders; Physical Stimulation; Rats; Rats, Sprague-Dawley; Stress, Psychological; Touch | 2020 |
Angiotensin II inhibits DDAH1-nNOS signaling via AT1R and μOR dimerization to modulate blood pressure control in the central nervous system.
Topics: Amidohydrolases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Dimerization; Extracellular Signal-Regulated MAP Kinases; Hypertension; Losartan; Male; Nitric Oxide; Nitric Oxide Synthase Type I; Oligopeptides; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptors, Opioid, mu; Signal Transduction; Solitary Nucleus | 2019 |
Losartan protects against intermittent hypoxia-induced peritubular capillary loss by modulating the renal renin-angiotensin system and angiogenesis factors.
Topics: Angiogenesis Inducing Agents; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Body Weight; Capillaries; Creatinine; Epithelial Cells; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Cortex; Losartan; Male; Protective Agents; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Sleep Apnea, Obstructive; Thrombospondin 1; Vascular Endothelial Growth Factor A | 2020 |
AT1 and AT2 receptors modulate renal tubular cell necroptosis in angiotensin II-infused renal injury mice.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Cell Line; Disease Models, Animal; Epithelial Cells; Humans; Imidazoles; Kidney Failure, Chronic; Kidney Tubules; Losartan; Male; Mice; Necroptosis; Oligopeptides; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Signal Transduction | 2019 |
Severe food restriction activates the central renin angiotensin system.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Arterial Pressure; Autoradiography; Caloric Restriction; Female; Heart Rate; Hypothalamus; Injections, Intraventricular; Losartan; Organum Vasculosum; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Peptidyl-Dipeptidase A; Preoptic Area; Rats; Rats, Inbred F344; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Starvation; Subfornical Organ | 2020 |
Hyperbaric oxygen activates visfatin expression and angiogenesis via angiotensin II and JNK pathway in hypoxic human coronary artery endothelial cells.
Topics: Angiotensin II; Anthracenes; Cell Movement; Cells, Cultured; Coronary Vessels; Cytokines; Endothelial Cells; Glucose; Humans; Hyperbaric Oxygenation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; JNK Mitogen-Activated Protein Kinases; Losartan; Neovascularization, Pathologic; Nicotinamide Phosphoribosyltransferase; Oxygen; Promoter Regions, Genetic; RNA, Small Interfering; Signal Transduction | 2020 |
Losartan promotes myocardial apoptosis after acute myocardial infarction in rats through inhibiting Ang II-induced JAK/STAT pathway.
Topics: Acute Disease; Angiotensin II; Animals; Antihypertensive Agents; Apoptosis; Disease Models, Animal; Injections, Intraperitoneal; Janus Kinase 2; Losartan; Male; Myocardial Infarction; Myocytes, Cardiac; Rats; Rats, Wistar; STAT3 Transcription Factor | 2020 |
Angiotensin Type 1 Receptors and Superoxide Anion Production in Hypothalamic Paraventricular Nucleus Contribute to Capsaicin-Induced Excitatory Renal Reflex and Sympathetic Activation.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetophenones; Acetylcysteine; Allopurinol; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Capsaicin; Captopril; Ditiocarb; Kidney; Losartan; Male; NADPH Oxidases; Onium Compounds; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Reflex; Superoxides | 2020 |
Pro-inflammatory cytokines in the paraventricular nucleus mediate the adipose afferent reflex in rats.
Topics: Adipose Tissue, White; Angiotensin II; Animals; Blood Pressure; Cytokines; Heart; Inflammation; Interleukin-1beta; Kidney; Losartan; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Reflex; Sympathetic Nervous System; Tumor Necrosis Factor-alpha | 2020 |
Increased angiotensin II from adipose tissue modulates myocardial collagen I and III in obese rats.
Topics: Adipose Tissue; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Collagen Type I; Collagen Type III; Diet, High-Fat; Fibrosis; Losartan; Male; Myocardium; Obesity; Rats; Rats, Wistar; Renin-Angiotensin System | 2020 |
Interaction between angiotensin II and GABA in the spinal cord regulates sympathetic vasomotor activity in Goldblatt hypertension.
Topics: Angiotensin II; Animals; Bicuculline; Blood Pressure; gamma-Aminobutyric Acid; Heart Rate; Hypertension, Renovascular; Losartan; Male; Rats, Wistar; Receptor, Angiotensin, Type 1; Spinal Cord; Sympathetic Nervous System | 2020 |
Persistent Renin-Angiotensin System Sensitization Months After Body Weight Recovery From Severe Food Restriction in Female Fischer Rats.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Body Weight; Female; Food Deprivation; Heart Rate; Losartan; Mesenteric Arteries; Peptidyl-Dipeptidase A; Rats, Inbred F344; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Vasoconstriction | 2020 |
Impaired angiotensin II type 1 receptor signaling contributes to sepsis-induced acute kidney injury.
Topics: Acute Kidney Injury; Angiotensin II; Animals; Case-Control Studies; Humans; Losartan; Mice; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sepsis | 2021 |
Calcitriol inhibits COX-1 and COX-2 expressions of renal vasculature in hypertension: Reactive oxygen species involved?
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Calcitriol; Cyclic N-Oxides; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Endothelium, Vascular; Free Radical Scavengers; Humans; Hypertension; Losartan; NADPH Oxidases; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Receptors, Calcitriol; Renal Artery; Spin Labels; Vasodilation | 2021 |
Angiotensin II enhances the proliferation of Natural Killer/T-cell lymphoma cells via activating PI3K/Akt signaling pathway.
Topics: Aged; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Cell Survival; Female; Heterocyclic Compounds, 3-Ring; Humans; Losartan; Lymph Nodes; Lymphoma, Extranodal NK-T-Cell; Male; Middle Aged; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Receptor, Angiotensin, Type 1; Signal Transduction; Wortmannin; Xenograft Model Antitumor Assays | 2020 |
N-Acetyl-Seryl-Asparyl-Lysyl-Proline regulates lung renin angiotensin system to inhibit epithelial-mesenchymal transition in silicotic mice.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cell Line; Epithelial-Mesenchymal Transition; Fibrosis; Losartan; Lung; Male; Mice, Inbred C57BL; Oligopeptides; Peptide Fragments; Peptidyl-Dipeptidase A; Renin-Angiotensin System; Silicosis | 2020 |
Angiotensinergic receptors in the medial amygdaloid nucleus differently modulate behavioral responses in the elevated plus-maze and forced swimming test in rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Behavior, Animal; Corticomedial Nuclear Complex; Imidazoles; Losartan; Male; Maze Learning; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Swimming | 2021 |
Pre-treatment with the angiotensin receptor 1 blocker losartan protects renal blood flow and oxygen delivery after propofol-induced hypotension in pigs.
Topics: Anesthetics, Intravenous; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Female; Hypotension; Kidney; Losartan; Male; Oxygen; Preoperative Care; Propofol; Recovery of Function; Renal Circulation; Swine; Vasoconstriction | 2020 |
The Possible Regulatory Mechanisms of Aqueous, Ethyl Acetate and NHexane Fractions of the Ribes khorassanicum Extract on Acute Hypertension in Rats.
Topics: Acetates; Acute Disease; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cardiovascular System; Disease Models, Animal; Hexanes; Hypertension; Losartan; Male; NG-Nitroarginine Methyl Ester; Plant Extracts; Rats; Rats, Wistar; Ribes; Signal Transduction; Water | 2021 |
Upregulated LRRC55 promotes BK channel activation and aggravates cell injury in podocytes.
Topics: Angiotensin II; Animals; Apoptosis; Calcium; Cell Nucleus; Humans; Intracellular Space; Ion Channel Gating; Kidney Glomerulus; Large-Conductance Calcium-Activated Potassium Channels; Losartan; Membrane Proteins; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; NFATC Transcription Factors; Podocytes; Potassium; Promoter Regions, Genetic; Protein Transport; TRPC6 Cation Channel; Up-Regulation | 2021 |
Angiotensin II Increases HMGB1 Expression in the Myocardium Through AT1 and AT2 Receptors When Under Pressure Overload.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Cardiomegaly; Case-Control Studies; Constriction; HMGB1 Protein; Imidazoles; Losartan; Male; Mice; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Pyridines; Up-Regulation; Vasoconstrictor Agents | 2021 |
A pressor dose of angiotensin II has no influence on the angiotensin-converting enzyme 2 and other molecules associated with SARS-CoV-2 infection in mice.
Topics: ADAM17 Protein; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; COVID-19; Furin; Gene Expression Regulation, Enzymologic; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; SARS-CoV-2; Serine Endopeptidases; Vasoconstrictor Agents | 2021 |
Evaluation of the Effect of Captopril and Losartan on Tacrolimus-induced Nephrotoxicity in Rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Urea Nitrogen; Captopril; Creatinine; Epithelium; Kidney Diseases; Kidney Tubules, Proximal; Losartan; Male; Peptidyl-Dipeptidase A; Rats; Renin-Angiotensin System; Tacrolimus | 2021 |
Renoprotective Effects of Small Interfering RNA Targeting Liver Angiotensinogen in Experimental Chronic Kidney Disease.
Topics: Angiotensin II; Angiotensinogen; Animals; Antihypertensive Agents; Arterial Pressure; Captopril; Disease Models, Animal; Kidney; Liver; Losartan; Rats; Renal Insufficiency, Chronic; Renin-Angiotensin System; RNA, Small Interfering | 2021 |
The AT-1 Angiotensin Receptor is Involved in the Autonomic and Neuroendocrine Responses to Acute Restraint Stress in Male Rats.
Topics: Angiotensin II; Animals; Autonomic Nervous System; Blood Pressure; Heart Rate; Hypothalamo-Hypophyseal System; Losartan; Male; Pituitary-Adrenal System; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Stress, Psychological | 2022 |
Losartan Protects Podocytes against High Glucose-induced Injury by Inhibiting B7-1 Expression.
Topics: Angiotensin II; Animals; Apoptosis; B7-1 Antigen; Class I Phosphatidylinositol 3-Kinases; Diabetic Nephropathies; Disease Models, Animal; Glucose; Humans; Kidney; Losartan; Mice; Podocytes; Rats; Receptor, Angiotensin, Type 1; Streptozocin | 2021 |
Megalin-mediated albumin endocytosis in renal proximal tubules is involved in the antiproteinuric effect of angiotensin II type 1 receptor blocker in a subclinical acute kidney injury animal model.
Topics: Acute Kidney Injury; Albumins; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cells, Cultured; Disease Models, Animal; Endocytosis; Kidney Tubules, Proximal; Losartan; Low Density Lipoprotein Receptor-Related Protein-2; Male; Mice; Mice, Inbred C57BL | 2021 |
An organ-on-a-chip model for pre-clinical drug evaluation in progressive non-genetic cardiomyopathy.
Topics: Angiotensin II; Animals; Cardiomyopathies; Cardiotonic Agents; Cell Line; Cell Survival; Coculture Techniques; Drug Evaluation, Preclinical; Fibroblasts; Fibrosis; Humans; Induced Pluripotent Stem Cells; Lab-On-A-Chip Devices; Losartan; Mice; Myocytes, Cardiac; Pilot Projects; Proteome; Proteomics; Recombinant Proteins; Relaxin; Ventricular Remodeling | 2021 |
Angiotensin II type 1 receptor blockade attenuates posttraumatic stress disorder-related chronic pain by inhibiting glial activation in the spinal cord.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Astrocytes; Chronic Pain; Hippocampus; Hyperalgesia; Losartan; Male; Microglia; Pain Threshold; Prefrontal Cortex; Rats; Receptor, Angiotensin, Type 1; Spinal Cord; Stress Disorders, Post-Traumatic; Stress, Psychological | 2021 |
Sex differences in angiotensin II-induced hypertension and kidney injury: role of AT1a receptors in the proximal tubule of the kidney.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Arterial Pressure; Disease Models, Animal; Female; Fibrosis; Hypertension; Kidney Diseases; Kidney Tubules, Proximal; Losartan; Male; Mice, Inbred C57BL; Mice, Knockout; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Sex Characteristics; Sex Factors; Signal Transduction | 2021 |
EHP-101 alleviates angiotensin II-induced fibrosis and inflammation in mice.
Topics: Administration, Oral; Angiotensin II; Animals; Anti-Inflammatory Agents; Cannabidiol; Fibroblasts; Fibrosis; Gene Expression Regulation; Inflammation; Losartan; Male; Mice; Mice, Inbred C57BL; Myocardium; Myofibroblasts | 2021 |
Vitamin D suppresses bleomycin-induced pulmonary fibrosis by targeting the local renin-angiotensin system in the lung.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Bleomycin; Disease Models, Animal; Ergocalciferols; Losartan; Lung; Mice; Mice, Inbred C57BL; Mice, Knockout; Pulmonary Fibrosis; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System; Transforming Growth Factor beta; Vitamin D | 2021 |
Soluble angiotensin-converting enzyme levels in heart failure or acute coronary syndrome: revisiting its modulation and prognosis value.
Topics: Acute Coronary Syndrome; ADAM17 Protein; Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme 2; Enalapril; Female; Heart Failure; Human Umbilical Vein Endothelial Cells; Humans; Kaplan-Meier Estimate; Losartan; Male; Metoprolol; Middle Aged; Peptidyl-Dipeptidase A; Prognosis | 2021 |
Both central sympathoexcitation and peripheral angiotensin II-dependent vasoconstriction contribute to hypertension development in immature heterozygous Ren-2 transgenic rats.
Topics: Angiotensin II; Animals; Blood Pressure; Hypertension; Losartan; Male; Rats; Rats, Transgenic; Renin; Renin-Angiotensin System; Vasoconstriction | 2022 |
Local Renin-Angiotensin System Signaling Mediates Cellular Function of Aortic Valves.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aortic Valve; Cells, Cultured; Fluorescent Antibody Technique; Losartan; Myofibroblasts; Peptidyl-Dipeptidase A; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Swine; Tetrahydroisoquinolines | 2021 |
Angiotensin II Type 1 Receptor Tachyphylaxis Is Defined by Agonist Residence Time.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Cell Membrane; HEK293 Cells; Humans; Losartan; Protein Binding; Receptor, Angiotensin, Type 1; Signal Transduction; Tachyphylaxis | 2022 |
In Vivo Renin Activity Imaging in the Kidney of Progeroid
Topics: Aging; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, Animal; DNA Damage; DNA Repair; DNA-Binding Proteins; Endonucleases; Female; Gene Expression Regulation; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Humans; Kidney; Losartan; Male; Mice; Mice, Knockout; Progeria; Renal Insufficiency, Chronic; Renin; Renin-Angiotensin System; Signal Transduction | 2021 |
Angiotensin Type 2 and Mas Receptor Activation Prevents Myocardial Fibrosis and Hypertrophy through the Reduction of Inflammatory Cell Infiltration and Local Sympathetic Activity in Angiotensin II-Dependent Hypertension.
Topics: Angiotensin I; Angiotensin II; Animals; Cardiomegaly; Disease Models, Animal; Fibrosis; Hypertension; Imidazoles; Injections, Intraperitoneal; Losartan; Male; Peptide Fragments; Proto-Oncogene Mas; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiophenes; Tyrosine 3-Monooxygenase | 2021 |
Angiotensin II-Induced Erythrocyte Senescence Contributes to Oxidative Stress.
Topics: Angiotensin II; Animals; Cellular Senescence; Erythrocytes; Losartan; Mice; Oxidative Stress | 2022 |
Divergent roles of angiotensin II upon the immediate and sustained increases of renal blood flow following unilateral nephrectomy.
Topics: Angiotensin II; Animals; Kidney; Losartan; Male; Nephrectomy; Rats; Rats, Sprague-Dawley; Renal Circulation; Renin-Angiotensin System | 2022 |
Cardiorenal protective effects of sodium-glucose cotransporter 2 inhibition in combination with angiotensin II type 1 receptor blockade in salt-sensitive Dahl rats.
Topics: Angiotensin II; Animals; Blood Pressure; Glucose; Humans; Hypertension; Losartan; Rats; Rats, Inbred Dahl; Receptor, Angiotensin, Type 1; Sodium; Sodium Chloride; Sodium Chloride, Dietary; Sodium-Glucose Transporter 2; Sodium-Hydrogen Exchanger 3 | 2022 |
Central angiotensinergic mechanisms in female spontaneously hypertensive rats treated with estradiol.
Topics: Angiotensin II; Animals; Estradiol; Female; Humans; Losartan; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; RNA, Messenger; Sodium Chloride | 2022 |
Activation of the Renin-Angiotensin System Disrupts the Cytoskeletal Architecture of Human Urine-Derived Podocytes.
Topics: Angiotensin II; Humans; Kidney; Kidney Diseases; Losartan; Podocytes; Renin-Angiotensin System | 2022 |
Ginsenoside Re attenuates memory impairments in aged Klotho deficient mice via interactive modulations of angiotensin II AT1 receptor, Nrf2 and GPx-1 gene.
Topics: Angiotensin II; Animals; Antioxidants; Ginsenosides; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Klotho Proteins; Losartan; Memory Disorders; Mice; Mice, Knockout; NF-E2-Related Factor 2; Reactive Oxygen Species; Receptor, Angiotensin, Type 1 | 2022 |
Estradiol Supplement or Induced Hypertension May Attenuate the Angiotensin II Type 1 Receptor Antagonist-Promoted Renal Blood Flow Response to Graded Angiotensin II Administration in Ovariectomized Rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Estradiol; Female; Hypertension; Losartan; Rats; Receptor, Angiotensin, Type 1; Renal Circulation | 2022 |
Cyclooxygenase-2 is a critical determinant of angiotensin II-induced vascular remodeling and stiffness in resistance arteries of ouabain-treated rats.
Topics: Angiotensin II; Animals; bcl-2-Associated X Protein; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Hydrochlorothiazide; Losartan; Matrix Metalloproteinase 2; Mesenteric Arteries; Ouabain; Rats; Rats, Wistar; Reactive Oxygen Species; Vascular Remodeling; Vascular Resistance | 2022 |
Angiotensin-(3-4) normalizes the elevated arterial blood pressure and abnormal Na+/energy handling associated with chronic undernutrition by counteracting the effects mediated by type 1 angiotensin II receptors.
Topics: Adenosine Triphosphatases; Angiotensin II; Animals; Arterial Pressure; Blood Pressure; Losartan; Male; Malnutrition; Rats; Rats, Wistar; Receptors, Angiotensin; Sodium | 2022 |
Inhibition of the Renin-Angiotensin System Fails to Suppress β-Aminopropionitrile-Induced Thoracic Aortopathy in Mice-Brief Report.
Topics: Aminopropionitrile; Angiotensin II; Angiotensinogen; Animals; Aortic Aneurysm, Thoracic; Aortic Rupture; Dilatation, Pathologic; Disease Models, Animal; Irbesartan; Losartan; Lysine; Male; Mice; Mice, Inbred C57BL; Protein-Lysine 6-Oxidase; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System | 2022 |
ATR1 Angiotensin II Receptor Reduces Hemoglobin S Polymerization, Phosphatidylserine Exposure, and Increases Deformability of Sickle Cell Disease Erythrocytes.
Topics: Acrylates; Anemia, Sickle Cell; Angiotensin II; Annexin A5; Erythrocytes; Hemoglobin, Sickle; Humans; Imidazoles; Losartan; Phosphatidylserines; Polymerization; Receptor, Angiotensin, Type 1; Thiophenes | 2022 |
Losartan metabolite EXP3179 is a unique blood pressure-lowering AT1R antagonist with direct, rapid endothelium-dependent vasoactive properties.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Endothelium; Imidazoles; Losartan; Mice; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1 | 2022 |
Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-κB and MAPK signaling.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiomyopathies; Losartan; Macrophages; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Receptor, Angiotensin, Type 1; Sepsis; Toll-Like Receptor 4 | 2022 |
Integrin subunit β-like 1 mediates angiotensin II-induced myocardial fibrosis by regulating the forkhead box Q1/Snail axis.
Topics: Angiotensin II; Animals; Cardiomyopathies; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Integrins; Losartan; Mice; Myocardium; RNA, Small Interfering; Transforming Growth Factor beta1 | 2022 |
Dysregulated ACE/Ang II/Ang1-7 signaling provokes cardiovascular and inflammatory sequelae of endotoxemia in weaning preeclamptic rats.
Topics: Angiotensin II; Animals; Endotoxemia; Female; Humans; Losartan; Peptidyl-Dipeptidase A; Pioglitazone; Pre-Eclampsia; Pregnancy; Rats; Renin-Angiotensin System; Weaning | 2022 |
LRP1 protects against excessive superior mesenteric artery remodeling by modulating angiotensin II-mediated signaling.
Topics: Angiotensin II; Angiotensinogen; Animals; Female; Losartan; Low Density Lipoprotein Receptor-Related Protein-1; Male; Mesenteric Artery, Superior; Mice; Signal Transduction | 2023 |
Inhibition of angiotensin II type 1 receptor partially prevents acute elevation of pulmonary arterial pressure induced by endovascular ethanol injection.
Topics: Angiotensin II; Animals; Arterial Pressure; Ethanol; Losartan; Male; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; RNA, Messenger; Swine | 2023 |
Losartan impairs HTR-8/SVneo trophoblast migration through inhibition of angiotensin II-induced pro-inflammatory profile in human endometrial stromal cells.
Topics: Angiotensin II; Endometrium; Female; Humans; Losartan; Matrix Metalloproteinase 2; Pregnancy; Prolactin; Receptor, Angiotensin, Type 1; Stromal Cells; Trophoblasts | 2023 |
Expression of Trpa1 and Trpv1 Genes in the Hypothalamus and Blood Pressure in Normotensive and Hypertensive Rats. Effect of Losartan and Captopril.
Topics: Angiotensin II; Animals; Blood Pressure; Captopril; Hypertension; Hypothalamus; Losartan; Rats; TRPA1 Cation Channel; TRPV Cation Channels | 2023 |
Design, synthesis and biological evaluation of novel indole-3-carboxylic acid derivatives with antihypertensive activity.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Hypertension; Losartan; Rats; Rats, Inbred SHR; Receptors, Angiotensin; Tetrazoles | 2023 |
Cardiac-specific BACH1 ablation attenuates pathological cardiac hypertrophy by inhibiting the Ang II type 1 receptor expression and the Ca2+/CaMKII pathway.
Topics: Angiotensin II; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomegaly; Fibrosis; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Myocytes, Cardiac | 2023 |
Unveiling Angiotensin II and Losartan-Induced Gene Regulatory Networks Using Human Urine-Derived Podocytes.
Topics: Angiotensin II; Gene Regulatory Networks; Humans; Hypertension; Losartan; Podocytes; Receptor, Angiotensin, Type 1 | 2023 |
Angiotensin II type 2 receptor-mediated dilation is greater in the cutaneous microvasculature of premenopausal women compared with men.
Topics: Angiotensin II; Dilatation; Female; Humans; Losartan; Male; Microvessels; Receptor, Angiotensin, Type 2; Vasoconstrictor Agents | 2023 |