losartan has been researched along with angiotensin i in 243 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 130 (53.50) | 18.2507 |
| 2000's | 68 (27.98) | 29.6817 |
| 2010's | 40 (16.46) | 24.3611 |
| 2020's | 5 (2.06) | 2.80 |
| Authors | Studies |
|---|---|
| Buczko, W; Kramkowski, K; Leszczynska, A; Mogielnicki, A | 1 |
| Brunner, HR; Christen, Y; Lee, RJ; Munafo, A; Nussberger, J; Waeber, B | 1 |
| Li, T; Zimmerman, BG | 1 |
| Fukuchi, S; Gomibuchi, T; Haga, H; Mizuno, K; Niimura, S; Sanada, H; Tani, M | 1 |
| Chiu, AT; McCall, DE; Roscoe, WA | 1 |
| Bennett, T; Gardiner, SM; Kemp, PA; Widdop, RE | 2 |
| Dunne, JF; Melching, G; Momiyama, M; Ransom, JT; Sharif, NA | 1 |
| Allen, AM; Mendelsohn, FA; Paxinos, G; Song, K | 1 |
| Fukuchi, S; Haga, H; Hashimoto, S; Mizuno, K; Niimura, S; Ohtsuki, M; Sanada, H; Tani, M; Watanabe, H | 1 |
| Brooks, DP; Edwards, RM; Fredrickson, TA; Gellai, M; Ruffolo, RR; Weinstock, J | 1 |
| Saavedra, JM; Strömberg, C; Tsutsumi, K; Viswanathan, M | 1 |
| Byrd, EW; Carr, BR; Rainey, WE; Sinnokrot, RA | 1 |
| Jackson, EK | 1 |
| Chappell, MC; Diz, DI; Ferrario, CM; Jaiswal, N; Khosla, MC | 1 |
| Jackson, EK; Pong, AS; Tofovic, SP | 1 |
| Baum, HP; Bunkenburg, B; Cumin, F; Schnell, C; Wood, JM | 1 |
| Fregly, MJ; Rowland, NE | 3 |
| Borland, RM; Brunner, HR; Christen, Y; Lee, RJ; Maggon, K; Nussberger, J; Porchet, M; Shum, L; Timmermans, PB; Waeber, B | 1 |
| Diz, DI; Ferrario, CM; Jaiswal, N; Khosla, MC; Tallant, EA | 1 |
| Campbell, DJ; Kladis, A; Valentijn, AJ | 1 |
| Milton, AE; New, AR; Tisher, CC; Weiner, ID | 1 |
| Cockcroft, JR; Goldberg, MR; Ritter, JM; Sciberras, DG | 1 |
| Arnet, U; Lüscher, TF; Siebenmann, R; Turina, M; von Segesser, L; Yang, Z | 1 |
| Mohabir, R; Strosberg, AM; Young, SD | 1 |
| Dean, RH; Ferrario, CM; Fuller, SB; Nakamoto, H; Robaczewski, DL; Winicov, E | 1 |
| Smith, RD | 1 |
| Gibson, KJ; Lumbers, ER; Stevenson, KM | 1 |
| Aubert, JF; Brunner, HR; Niederberger, M; Nussberger, J; Waeber, B | 1 |
| Ahima, RS; Kadowitz, PJ; Khosla, MC; Minkes, RK; Osei, SY; Weaver, JP | 1 |
| Berdeaux, A; Giudicelli, JF; Richard, V | 1 |
| Carr, RD; Henderson, IW; Mahon, JM; Nicol, AK | 1 |
| Devineni, VR; Henegar, JR; Janicki, JS; Kabour, A | 1 |
| Cohen, RB; Delaney, CL; Dickinson, KE; Gu, Z; Moreland, S; Poss, MA; Powell, JR; Ryono, DE; Serafino, RP; Skwish, S | 1 |
| Garcia, NH; Garvin, JL | 1 |
| Smith, RD; Timmermans, PB | 1 |
| Bottari, SP; Metzger, R; Paul, M; Steckelings, UM; Stoll, M; Unger, T | 1 |
| Campagnole-Santos, MJ; Fontes, MA; Guertzenstein, PG; Khosla, MC; Santos, RA; Silva, LC | 1 |
| Lantelme, P; Liu, KL; Lo, M; Sassard, J | 1 |
| Catalioto, RM; Criscuoli, M; Mizrahi, J; Renzetti, AR; Subissi, A | 1 |
| Aylett, AJ; Ball, SG; Balmforth, AJ; Bryson, SE; Drew, GM; Middlemiss, D; Pun, KT; Warburton, P | 1 |
| Blake, DR; Knock, GA; Polak, JM; Suzuki, T; Walsh, DA; Wharton, J | 1 |
| Dzau, VJ; Ellison, KE; Gibbons, GH; Kaneda, Y; Lee, W; Morishita, R; Ogihara, T; Yu, H; Zhang, L | 1 |
| Adler-Graschinsky, E; Enero, MA; Gironacci, MM; Peña, C | 1 |
| Pfaffendorf, M; van Zwieten, PA; Zhang, J | 1 |
| Cierco, M; Israel, A | 1 |
| André, P; Corriu, C; Michel, M; Schott, C; Stoclet, JC | 1 |
| Feng, CJ; Kadowitz, PJ; Nossaman, BD; Wang, J | 1 |
| Heemskerk, FM; Michels, KM; Saavedra, JM | 1 |
| Brasch, H; Dominiak, P; Sieroslawski, L | 1 |
| Bühlmayer, P; Criscione, L; de Gasparo, M; Ramjoué, HP; Whitebread, S; Wood, J | 1 |
| Cazaubon, C; Chatelain, P; Delisée, C; Schaeffer, P | 1 |
| Castillo, G; Esteban, S; Orce, G | 1 |
| da Silva, SV; da Silva, VJ; Salgado, HC; Salgado, MC | 1 |
| Berdeaux, A; Ghaleh, B; Giudicelli, JF; Richard, V | 1 |
| Cooney, AS; Fitzsimons, JT | 1 |
| Porter, JP; Toney, GM | 1 |
| Inagami, T; Inui, H; Iwai, N; Kato, H; Kimoto, K; Uchiyama, Y | 1 |
| Dickinson, KE; Michel, I; Monshizadegan, H; Moreland, S; Murphy, TJ; Seiler, SM; Serafino, R; Webb, ML | 1 |
| Baubonis, W; Benfield, P; Chiu, AT; Dunscomb, JH; McCall, DE; Sauer, B | 1 |
| Fukamizu, A; Hatae, T; Kajiwara, N; Murakami, K; Seo, MS; Sugimura, K; Sugiyama, F; Takahashi, S; Takimoto, E; Yagami, K | 1 |
| Belz, GG; de Mey, C; Goldberg, MR; Li, Q; Schroeter, V; Wroblewski, JM | 1 |
| Sim, MK; Soh, KS | 1 |
| Barthelmebs, M; Grima, M; Imbs, JL | 1 |
| Alt-Tebacher, M; Barthelmebs, M; Grima, M; Imbs, JL; Madonna, O | 1 |
| Brunner, HR | 1 |
| Cheung, WT; Sum, CS | 1 |
| Kjeldsen, SE; Omvik, P | 1 |
| Cicutti, N; Kolar, F; Korecky, B; Papousek, F; Rakusan, K; Sladek, T; Sladkova, J | 1 |
| Chai, SK; Sim, MK | 1 |
| Barnes, NM; Brown, DC; Ge, J; Steward, LJ | 1 |
| Braszko, J | 1 |
| Chow, L; Cumin, F; De Gasparo, M; Levens, N; Zakrzewska, K | 1 |
| Li, XC; Widdop, RE | 1 |
| Haneda, T; Kikuchi, K; Miyata, S; Osaki, J | 1 |
| Cheung, WT; Sum, CS; Wan, DC | 1 |
| Zimlichman, R | 1 |
| Campagnole-Santos, MJ; Fontes, MA; Khosla, MC; Lima, DX; Oliveira, RC; Santos, RA | 1 |
| Harris, PJ; Hiranyachattada, S | 1 |
| Barrès, C; Bertolino, S; Cuisinaud, G; Julien, C; Medeiros, IA; Vincent, M | 1 |
| Berrino, L; D'Amico, M; di Filippo, C; Rossi, F | 1 |
| Azizi, M; Chatellier, G; Guyene, TT; Ménard, J; Wargon, M | 1 |
| Forster, C; le Tran, Y | 2 |
| Higson, JT; Tallant, EA | 1 |
| Campagnole-Santos, MJ; Fontes, MA; Khosla, MC; Lopes, OU; Martins Pinge, MC; Naves, V; Santos, RA | 1 |
| Epstein, M; Forster, HG; ter Wee, PM | 1 |
| Armentano, RL; Barra, JG; Cabrera Fischer, EI; Levenson, J; Pichel, RH; Simon, A | 1 |
| Andonegui, G; Geffner, JR; Giordano, M; López, DH; Nahmod, V; Raiden, S; Trevani, AS | 1 |
| García-Sáinz, JA; Macías-Silva, M; Olivares-Reyes, JA | 1 |
| García-Sáinz, JA; González-Espinosa, C; Martínez-Alfaro, M; Romero-Avila, MT | 1 |
| Higaki, J; Kamide, K; Mikami, H; Moriguchi, A; Nagano, M; Nakano, N; Ogihara, T; Yo, Y; Yu, H | 1 |
| Hashimoto, K; Mikoshiba, I; Okuhira, M; Tamura, K | 1 |
| Hunyady, L; Nagy, L | 1 |
| Jin, D; Miyazaki, M; Oka, Y; Shiota, N; Song, K; Takai, S | 1 |
| Chappell, MC; Ferrario, CM; Iyer, SN | 1 |
| Averill, DB; Chappell, MC; Diz, DI; Ferrario, CM; Iyer, SN | 1 |
| Boon, NA; Johnston, NR; Masumori, S; Newby, DE; Webb, DJ | 1 |
| Mineshita, S; Shimakura, K; Wang, LM; Xu, ZH; Yamamoto, T | 1 |
| Mutschler, E; Soldner, A; Spahn-Langguth, H | 1 |
| Mutschler, E; Palm, D; Soldner, A; Spahn-Langguth, H | 1 |
| Johns, EJ; Wong, PS | 1 |
| Hymel, A; Imig, JD; Navar, LG; Zou, LX | 1 |
| Dendorfer, A; Dominiak, P; Häuser, W; Nguyen, T | 1 |
| Fechter, K; Heyne, N; Khosla, MC; Richter, K; Vallon, V | 1 |
| Campbell, SE; Dhalla, AK; Kandala, JC; Katwa, LC; Sun, Y; Tyagi, SC; Weber, KT | 1 |
| Chappell, MC; Ferrario, CM; Ganten, D; Iyer, SN; Yamada, K | 1 |
| Struthers, AD | 1 |
| Anders, HJ; Ertl, G; Gaudron, P; Hu, K; Nahrendorf, M; Turschner, O; Weidemann, F | 1 |
| Baracho, NC; Khosla, MC; Santos, RA; Simões-e-Silva, AC | 1 |
| Coimbra, CC; Machado, LJ; Marubayashi, U; Reis, AM | 1 |
| Mendelsohn, FA; Ohishi, M; Zhuo, J | 1 |
| Anwar, M; Ibrahim, IN; Kadowitz, PJ; Kaye, AD; Nossaman, BD; Smith, DE | 1 |
| Brosnihan, KB; Chappell, MC; Ferrario, CM; Fukuhara, M; Iyer, SN; Yamada, K | 1 |
| Rauch, M; Schmid, HA | 1 |
| Borthayre, AB; Harrison, DG; Hink, U; Kurz, S; Münzel, T; Nickenig, G | 1 |
| Azizi, M; Chatellier, G; Guyene, TT; Ménard, J | 1 |
| Bellissant, E; Durand-Castel, X; Goineau, S; Guillo, P; Pape, D | 1 |
| Burrell, JH; Gibson, KJ; Lumbers, ER; McMullen, JR; Wu, J | 1 |
| Dukacz, SA; Kline, RL | 1 |
| Navar, LG; Wang, CT; Zou, LX | 1 |
| Riegger, GA | 1 |
| Coba, MP; Gironacci, MM; Peña, C | 1 |
| Coviello, A; Peral de Bruno, M; Romano, L | 1 |
| Jung, YS; Lee, BH; Lee, SH; Seo, HW; Shin, HS; Yoo, SE | 1 |
| Anderson, P; Bolger, G; Jaramillo, J; Jung, G; Lamarre, D; Liard, F; Pilote, L; Simoneau, B; Thibeault, D; Vigeant, JC | 1 |
| Kasahara, T; Kawano, H; Kimura, S; Kitamura, H; Kunieda, Y; Masuda, H; Nakagawa, K; Nakagawa, M; Nakahara, Y; Nishimura, H; Sawada, S; Sugano, T; Tsuji, H; Yano, S; Yoshizumi, M | 1 |
| Kamata, K; Mizutani, K | 1 |
| Dixon, B; Rowe, BP | 1 |
| Petkun, W | 1 |
| Danser, AH; Kroon, I; Saris, JJ; Schalekamp, MA; van Dijk, MA | 1 |
| Cervenka, L; Heller, J; Horácek, V; Kramer, HJ; Malý, J | 1 |
| Ferrario, CM; Redon, J | 1 |
| Chappell, MC; Diz, DI; Ferrario, CM; Iyer, SN; Yamada, K | 1 |
| Cho, KW; Kim, SH; Kim, SZ; Kim, YG; Park, JK | 1 |
| Andrade, SP; Campagnole-Santos, MJ; Santos, RA | 1 |
| Coviello, A; Jerez, S; Peral de Bruno, M; Santos, JC | 1 |
| Crespo, MJ | 1 |
| Min, L; Sim, MK; Xu, XG | 1 |
| Chiu, SM; Prescott, G; Reudelhuber, TL; Silversides, DW | 1 |
| Cheetham, C; Green, D; O'Driscoll, G; Stanton, K; Taylor, R | 1 |
| Chiba, S; Fukumori, R; Ibusuki, T; Kambe, T; Kubo, T | 1 |
| Burnier, M | 1 |
| Andrade, SP; Machado, RD; Santos, RA | 1 |
| Connell, JM; Hillier, C; McDonald, JE; McMurray, JJ; Padmanabhan, N; Petrie, MC | 1 |
| DiBona, GF; Jones, SY | 1 |
| Fabiani, ME; Frauman, AG; Johnston, CI; Sourial, M; Thomas, WG | 1 |
| Delbridge, LM; Griffiths, CD; Morgan, TO | 1 |
| Leenen, FH; White, R; Yuan, B | 1 |
| Bica, RB; Caruso-Neves, C; Correa, JS; Lara, LS; Lopes, AG; Marques-Fernandes, MF; Sena, SL | 1 |
| Beevers, DG; Lip, GY | 1 |
| Pitt, B | 1 |
| Buczko, W; Chabielska, E; Kucharewicz, I; Matys, T; Pawlak, D; Rólkowski, R | 1 |
| Duggan, KA; Hodge, G; Ye, VZ | 1 |
| Barthelmebs, M; Coquard, C; Grima, M; Imbs, JL; Ingert, C | 1 |
| Buczko, W; Kucharewicz, I; Matys, T; Pawlak, D; Pawlak, R | 1 |
| Dobrucki, LW; Heitsch, H; Louka, FR; Malinski, T; Wiemer, G | 1 |
| Averill, DB; Brosnihan, KB; Chappell, MC; Diz, DI; Ferrario, CM; Nakamura, S | 1 |
| Alhenc-Gelas, F; Chollet, C; Helou, CM; Marchetti, J; Rajerison, R | 1 |
| Browne, AE; Chatterjee, K; Grossman, W; Karliner, JS; Lee, RJ; Parmley, WW; Sievers, RE; Zhu, BQ | 1 |
| Bild, W; Boisteanu, CP; Haulica, I; Ionita, T; Mihaila, CN; Neagu, B | 1 |
| Hannaway, PJ; MacLean, JA | 1 |
| Bond, R; Brinsa, TA; Dell'Italia, L; Diwan, A; Evans, K; Flesch, M; Höper, A; Mann, DL; Peshock, R; Sivasubramanian, N; Spinale, FG; Wei, CC | 1 |
| Preobrazhenskiĭ, DV; Sidorenko, BA; Stetsenko, TM; Tarykina, EV; Tsurko, VV | 2 |
| Dominiak, P; Häuser, W | 1 |
| Collister, JP; Hendel, MD | 1 |
| Averill, DB; Brosnihan, KB; Ferrario, CM; Gallagher, PE; Ishiyama, Y; Tallant, EA | 1 |
| Carey, RM | 1 |
| Hagiwara, Y; Kubo, T | 1 |
| Abi-Abib, R; Cardozo, FP; Caruso-Neves, C; De Souza, AM; Fernandes, MS; Fossari, RN; Lopes, AG; Miguel, NC; Pizzino, CP; Santos, DP | 1 |
| Chester, AH; Hafizi, S; Yacoub, MH | 1 |
| De Mello, WC; Monterrubio, J | 1 |
| Oberhauser, V; Rump, LC; Sellin, L; Stegbauer, J; Vonend, O | 1 |
| Campbell, DJ; Esler, MD; Krum, H | 1 |
| Ecarnot-Laubriet, A; Oudot, A; Rochette, L; Vergely, C | 1 |
| Averill, DB; Brosnihan, KB; Chappell, MC; Diz, DI; Ferrario, CM; Gallagher, PE; Jessup, J; Tallant, EA | 1 |
| Wolf, G | 1 |
| Alenina, N; Almeida, AP; Bader, M; Castro, CH; Ferreira, AJ; Santos, RA | 1 |
| Chappell, MC; Ferrario, CM; Gallagher, PE; Tallant, EA | 1 |
| Ann Tallant, E; Averill, DB; Brosnihan, KB; Chappell, MC; Ferrario, CM; Gallagher, PE; Jessup, J; Smith, RD | 1 |
| Butler, DG | 1 |
| Averill, DB; Brosnihan, KB; Chappell, MC; Ferrario, CM; Gallagher, PE; Jessup, JA; Tallant, EA | 1 |
| Peña, C; Pereyra-Alfonso, S; Rodríguez de Lores Arnaiz, G | 1 |
| Karamyan, VT; Speth, RC | 1 |
| Campagnole-Santos, MJ; Ferreira, PM; Souza Dos Santos, RA | 1 |
| Dominici, FP; Giani, JF; Gironacci, MM; Muñoz, MC; Peña, C; Turyn, D | 1 |
| Gironacci, MM; Peña, C; Polizio, AH; Tomaro, ML | 1 |
| Anton, L; Brosnihan, KB; Merrill, DC; Neves, LA | 1 |
| Araujo, IG; Lepletier, A; Mecawi, AS; Olivares, EL; Reis, LC | 1 |
| Campbell, WB; Cui, L; Gauthier, KM; Nithipatikom, K; Zhang, DX | 1 |
| Achike, FI; Dharmani, M; Mustafa, MR; Sim, MK | 1 |
| Ferrario, CM; Gallagher, PE; Tallant, EA | 1 |
| Clarke, D; Medow, MS; Ocon, AJ; Stewart, JM; Taneja, I | 1 |
| Anton, L; Brosnihan, KB; Corthorn, J; Diz, DI; Gallagher, PE; Gruver, C; Merrill, DC; Moorefield, C; Neves, LA; Stovall, K; Valdes, G | 1 |
| Alzamora, AC; Campagnole-Santos, MJ; Cangussu, LM; de Castro, UG; do Pilar Machado, R; dos Santos, RA; Ferreira, PM; Silva, ME | 1 |
| Apostolakis, S; Krambovitis, E; Spandidos, DA; Vlata, Z; Vogiatzi, K | 1 |
| Chappell, MC; Diz, DI; Gwathmey, TM; Pendergrass, KD; Reid, SD; Rose, JC | 1 |
| Gao, J; Gao, XY; Han, Y; Shi, Z; Yuan, N; Zhou, LM; Zhu, GQ | 1 |
| Chudakov, DM; Guo, F; Kasparov, S; Lane, S; Liu, B; Paton, JF; Souslova, EA; Tang, F | 1 |
| Burns, KD; Dilauro, M; Genest, D; Robertson, SJ; Zimpelmann, J | 1 |
| Chang, A; Deb, DK; Kong, J; Li, YC; Zhang, Y | 1 |
| Durand, MJ; Lombard, JH; Raffai, G; Weinberg, BD | 1 |
| Loke, WK; Ng, ET; Sim, MK | 1 |
| Cassis, LA; Daugherty, A; Gurley, SB; Howatt, DA; Lu, H; Thatcher, SE; Zhang, X | 1 |
| Gutierréz-Reyes, G; Guzmán, C; Hiriart, M; Olivares-Reyes, JA; Pérez-Díaz, I; Ramírez, T; Robles-Díaz, G | 1 |
| Lee, KO; Sim, MK; Wong, YC | 1 |
| Cao, K; Chen, XM; Huang, HJ; Huang, J; Lu, XZ; Qin, XY; Yang, XH; Yong, YH; Zheng, HJ; Zong, WN | 1 |
| Asami, M; Kato, J; Kitamura, K; Kuwasako, K; Nagata, S | 1 |
| Bos, AP; Florquin, S; Kamilic, J; Lutter, R; Moll, GN; Specht, PA; van der Loos, CM; van Goor, H; van Woensel, JB; Wösten-van Asperen, RM | 1 |
| Alenina, N; Bader, M; de Oliveira, ML; Dos Santos, RA; Fontes, WR; Lazaroni, TL; Moraes, MF; Pereira, GS; Raslan, AC | 1 |
| Boustany-Kari, CM; Cassis, LA; Gupte, M; Karounos, M; Shoemaker, R; Thatcher, SE; Yiannikouris, F; Zhang, X | 1 |
| Huang, Y; Lu, L; Ni, J; Wang, J; Wang, Z; Xue, H; Yao, T; Yu, C; Yuan, P; Zhou, L | 1 |
| Akhtar, S; Benter, IF; Dhaunsi, GS; Makki, BM; Qabazard, BA; Yousif, MH | 1 |
| Chen, WW; Han, Y; Li, P; Sun, HJ; Xiong, XQ | 1 |
| Santos, KL; Speth, RC; Vento, MA; Wright, JW | 1 |
| Bader, M; Castro Perez, A; Duarte, ID; Lima, Mde P; Pacheco, CM; Pacheco, Dda F; Pesquero, JL; Souza, Ade L | 1 |
| Almeida, JF; Alves, GM; Castro, CH; Colugnati, DB; Ferreira, AJ; Macedo, LM; Mendes, EP; Porto, JE; Santos, RA; Sobrinho, DB; Souza, ÁP; Vêncio, EF | 1 |
| Bader, M; Barroso, LC; Coelho, FM; Costa, VV; Oliveira, ML; Queiroz-Junior, CM; Santos, RA; Silva, AC; Silva, TA; Silveira, KD; Sousa, LF; Teixeira, MM; Vieira, AT | 1 |
| Arantes, RM; Bader, M; Barroso, LC; Cisalpino, D; Dos Santos, RA; Lima, CX; Silveira, KD; Simões-E-Silva, AC; Teixeira, MM; Vieira, AT | 1 |
| Chen, Q; Huang, Y; Liu, L; Pan, C; Qiu, H; Yang, Y | 1 |
| Ding, W; Gu, Y; Xu, C; Zhang, M | 1 |
| Crestani, S; da Silva-Santos, JE; Gasparotto Júnior, A; Marques, MC; Sullivan, JC; Webb, RC | 1 |
| Chen, X; Dong, B; Hao, QQ; Li, SY; Wang, N; Wang, XY; Yu, QT; Zhang, YH; Zhu, L | 1 |
| Amorim, MJ; Bento-Leite, A; Brás-Silva, C; Castro-Chaves, P; Cerqueira, R; Leite-Moreira, AF; Mendes-Ferreira, P; Mendonça, L; Pinho, P | 1 |
| Dong, M; Guan, J; Meng, X; Niu, R; Sun, Y; Yang, J; Yang, X; Zhang, C; Zhang, Y | 1 |
| Loke, WK; Sethi, G; Sim, MK; Wang, H | 1 |
| Han, Y; Li, P; Sun, HJ; Zhang, F | 1 |
| Bastos, CP; Lazaroni, TL; Moraes, MF; Pereira, GS; Santos, RS | 1 |
| Brzozowski, T; Konturek, SJ; Korbut, R; Kwiecien, S; Madej, J; Olszanecki, R; Pajdo, R; Pawlik, MW; Ptak-Belowska, A; Suski, M; Targosz, A | 1 |
| Arnold, MR; Forte, BL; Hay, M; Largent-Milnes, TM; Slosky, LM; Staatz, WD; Vanderah, TW; Zhang, H | 1 |
| Alves, PH; Castro, CH; Colugnati, DB; Macedo, LM; Mendes, EP; Nunes, AD; Pedrino, GR; Santos, RA; Souza, AP | 1 |
| Abuohashish, HM; Ahmed, MM; Al-Rejaie, SS; Khattab, MM; Sabry, D | 1 |
| Healy, V; Johns, EJ; O'Neill, J | 1 |
| Casarini, DE; Ceron, CS; Fernandes, FB; Guimaraes, DA; Martins-Oliveira, A; Oliveira, DMM; Pinheiro, LC; Rizzi, E; Tanus-Santos, JE; Tirapelli, CR | 1 |
| Campos, GV; Chianca, D; De Menezes, RCA; De Souza, AMA; Ji, H; Linares, A; Sandberg, K; Speth, RC | 1 |
| Gao, X; Ge, X; Jin, F; Li, S; Li, Y; Mao, N; Wei, Z; Xu, H; Yang, F; Yang, Y; Zhang, M; Zhang, Y | 1 |
| Costa-Ferreira, W; Crestani, CC; Marchi-Coelho, C; Moreno-Santos, B | 1 |
| Balachandran, K; Ozkizilcik, A; Patel, S; Sysavanh, F; Tandon, I | 1 |
| Carletti, R; Castoldi, G; di Gioia, CRT; Ippolito, S; Pelucchi, S; Stella, A; Zatti, G; Zerbini, G | 1 |
12 review(s) available for losartan and angiotensin i
| Article | Year |
|---|---|
Human angiotensin receptor subtypes.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; DNA, Complementary; Gene Library; Humans; Imidazoles; Losartan; Oligopeptides; Pyridines; Receptors, Angiotensin; Tetrazoles | 1994 |
[Losartan and the LIFE-study. Antihypertensive treatment with AT1-receptor antagonist].
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Humans; Hypertension; Hypertrophy, Left Ventricular; Imidazoles; Losartan; Randomized Controlled Trials as Topic; Scandinavian and Nordic Countries; Tetrazoles; United States | 1996 |
[Angiotensin-2 receptor blockade--new therapeutic approach to treatment of hypertension].
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Tetrazoles | 1996 |
[AT1 angiotensin receptor inhibition as a new therapeutic possibility].
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Female; Heart Failure; Humans; Hypertension; Losartan; Renin-Angiotensin System | 1997 |
[ACE inhibitors or AT1 receptor antagonists?].
Topics: Age Factors; Aged; Angiotensin I; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Captopril; Clinical Trials as Topic; Death, Sudden, Cardiac; Enalapril; Heart Failure; Humans; Losartan; Prodrugs; Prognosis; Randomized Controlled Trials as Topic; Risk Factors; Tetrazoles; Time Factors | 1999 |
Angiotensin-(1-7): an update.
Topics: Angiotensin I; Angiotensin II; Animals; Blood Vessels; Central Nervous System; Humans; Kidney; Losartan; Models, Biological; Myocardium; Peptide Fragments; Peptidyl-Dipeptidase A; Protein Binding; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Signal Transduction; Vasoconstriction | 2000 |
Angiotensin II type 1 receptor blockers.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Binding, Competitive; Biphenyl Compounds; Blood Pressure; Drug Design; Humans; Irbesartan; Losartan; Peptidyl-Dipeptidase A; Protein Binding; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin-Angiotensin System; Saralasin; Tetrazoles; Valine; Valsartan | 2001 |
The protective effect of blocking angiotensin in both type I and type II diabetics with nephropathy.
Topics: Aged; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Compounds; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Irbesartan; Losartan; Male; Middle Aged; Primary Prevention; Prognosis; Randomized Controlled Trials as Topic; Risk Assessment; Sensitivity and Specificity; Tetrazoles; Treatment Outcome | 2001 |
Clinical trials of angiotensin receptor blockers in heart failure: what do we know and what will we learn?
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Clinical Trials as Topic; Forecasting; Heart Failure; Humans; Losartan; Renin-Angiotensin System | 2002 |
[Blocker of angiotensin-1 receptor antagonist losartan. Part III. Experience in therapy for chronic heart failure and after acute myocardial infarction].
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Antihypertensive Agents; Heart Failure; Humans; Losartan; Myocardial Infarction; Prognosis; Randomized Controlled Trials as Topic; Treatment Outcome | 2003 |
[Angiotensin I receptor antagonist losartan. Part II. Effects in arterial hypertension and diabetic nephropathy].
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diastole; Diuretics; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Irbesartan; Losartan; Meta-Analysis as Topic; Placebos; Prognosis; Randomized Controlled Trials as Topic; Sodium Chloride Symporter Inhibitors; Systole; Tetrazoles; Time Factors; Treatment Outcome; Valine; Valsartan | 2003 |
[The renin-angiotensin-aldosterone system -- more complex as previously thought].
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Chronic Disease; Chymases; Clinical Trials as Topic; Diabetic Nephropathies; Disease Progression; Drug Therapy, Combination; Humans; Indoles; Kidney Diseases; Kidney Tubules, Proximal; Losartan; Prospective Studies; Receptors, Angiotensin; Renin-Angiotensin System; Risk Factors; Serine Endopeptidases | 2005 |
13 trial(s) available for losartan and angiotensin i
| Article | Year |
|---|---|
Clinical experience with angiotensin II receptor antagonists.
Topics: Administration, Oral; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Humans; Hypertension; Imidazoles; Injections, Intravenous; Losartan; Renin-Angiotensin System; Tetrazoles; Time Factors | 1992 |
Oral administration of DuP 753, a specific angiotensin II receptor antagonist, to normal male volunteers. Inhibition of pressor response to exogenous angiotensin I and II.
Topics: Administration, Oral; Adult; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Blood Pressure; Drug Evaluation; Heart Rate; Humans; Imidazoles; Losartan; Male; Renin-Angiotensin System; Tetrazoles | 1991 |
Comparison of angiotensin-converting enzyme inhibition with angiotensin II receptor antagonism in the human forearm.
Topics: Adult; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Pressure; Bradykinin; Double-Blind Method; Drug Interactions; Enalapril; Forearm; Heart Rate; Humans; Imidazoles; Losartan; Male; Regional Blood Flow; Tetrazoles; Vascular Resistance; Vasoconstriction; Vasodilation | 1993 |
Differential effects of oral losartan and enalapril on local venous and systemic pressor responses to angiotensin I and II in healthy men.
Topics: Administration, Oral; Adult; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Double-Blind Method; Enalapril; Hand; Humans; Imidazoles; Losartan; Male; Reference Values; Renin; Tetrazoles; Vasoconstriction; Veins | 1996 |
[Losartan and the LIFE-study. Antihypertensive treatment with AT1-receptor antagonist].
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Humans; Hypertension; Hypertrophy, Left Ventricular; Imidazoles; Losartan; Randomized Controlled Trials as Topic; Scandinavian and Nordic Countries; Tetrazoles; United States | 1996 |
Additive effects of losartan and enalapril on blood pressure and plasma active renin.
Topics: Adolescent; Adult; Aldosterone; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Enalapril; Heart Rate; Humans; Hydrocortisone; Imidazoles; Losartan; Male; Peptidyl-Dipeptidase A; Renin; Tetrazoles; Time Factors | 1997 |
[AT1 angiotensin receptor inhibition as a new therapeutic possibility].
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Female; Heart Failure; Humans; Hypertension; Losartan; Renin-Angiotensin System | 1997 |
Endogenous angiotensin II contributes to basal peripheral vascular tone in sodium deplete but not sodium replete man.
Topics: Adult; Analysis of Variance; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Vessels; Bradykinin; Diuretics; Dose-Response Relationship, Drug; Forearm; Furosemide; Humans; Losartan; Lower Body Negative Pressure; Male; Norepinephrine; Regional Blood Flow; Sodium; Sodium, Dietary; Vasoconstriction; Vasoconstrictor Agents | 1997 |
A radioreceptor assay for the analysis of AT1-receptor antagonists. Correlation with complementary LC data reveals a potential contribution of active metabolites.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Proteins; Chromatography, High Pressure Liquid; Double-Blind Method; Humans; Imidazoles; Losartan; Male; Placebos; Pyrimidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Angiotensin; Reference Values; Sensitivity and Specificity; Tetrazoles | 1998 |
Pharmacokinetic-pharmacodynamic interactions of candesartan cilexetil and losartan.
Topics: Administration, Oral; Adolescent; Adult; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Double-Blind Method; Humans; Losartan; Male; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin; Tetrazoles | 1999 |
Functional importance of angiotensin-converting enzyme-dependent in situ angiotensin II generation in the human forearm.
Topics: Adolescent; Adult; Aged; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Brachial Artery; Enalaprilat; Endothelium, Vascular; Forearm; Humans; Losartan; Male; Middle Aged; Peptidyl-Dipeptidase A; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Regional Blood Flow; Vasoconstriction | 2000 |
Losartan, an angiotensin type I receptor antagonist, improves conduit vessel endothelial function in Type II diabetes.
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Endothelium, Vascular; Female; Humans; Losartan; Male; Middle Aged; Vasodilation | 2001 |
Losartan increases bradykinin levels in hypertensive humans.
Topics: Acrylates; Adolescent; Adult; Aged; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Bradykinin; Chromatography, High Pressure Liquid; Cross-Over Studies; Double-Blind Method; Female; Humans; Hydroxylation; Hypertension; Imidazoles; Kallidin; Losartan; Male; Middle Aged; Peptide Fragments; Radioimmunoassay; Thiophenes | 2005 |
220 other study(ies) available for losartan and angiotensin i
| Article | Year |
|---|---|
Angiotensin-(1-9), the product of angiotensin I conversion in platelets, enhances arterial thrombosis in rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arteries; Blood Platelets; Humans; Losartan; Male; Partial Thromboplastin Time; Peptide Fragments; Platelet Aggregation; Prothrombin Time; Rats; Rats, Wistar; Thrombosis | 2010 |
Relation between inhibition of renal angiotensin II production and hemodynamic effect of captopril in anesthetized rabbit.
Topics: Angiotensin I; Angiotensin II; Animals; Biphenyl Compounds; Captopril; Dose-Response Relationship, Drug; Hemodynamics; Imidazoles; Kidney; Losartan; Male; Rabbits; Renal Circulation; Renin-Angiotensin System; Sodium, Dietary; Tetrazoles | 1992 |
Antihypertensive and hormonal activity of MK 954 in spontaneously hypertensive rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Hormones; Hypertension; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin; Renin-Angiotensin System; Tetrazoles | 1992 |
[125I]EXP985: a highly potent and specific nonpeptide radioligand antagonist for the AT1 angiotensin receptor.
Topics: Adrenal Cortex; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Biphenyl Compounds; Dose-Response Relationship, Drug; Imidazoles; Iodine Radioisotopes; Ligands; Losartan; Microsomes; Muscle, Smooth, Vascular; Rats; Tetrazoles | 1992 |
Inhibition of the haemodynamic effects of angiotensin II in conscious rats by AT2-receptor antagonists given after the AT1-receptor antagonist, EXP 3174.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Hemodynamics; Imidazoles; Losartan; Male; Pyridines; Rats; Regional Blood Flow; Tetrazoles | 1992 |
AT1 angiotensin receptors mobilize intracellular calcium in a subclone of NG108-15 neuroblastoma cells.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Calcium; Imidazoles; Intracellular Membranes; Losartan; Neuroblastoma; Receptors, Angiotensin; Tetrazoles; Tumor Cells, Cultured | 1992 |
Mapping of angiotensin II receptor subtype heterogeneity in rat brain.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding, Competitive; Biphenyl Compounds; Brain; Brain Mapping; Dithiothreitol; Imidazoles; Iodine Radioisotopes; Losartan; Male; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles | 1992 |
Losartan, a specific angiotensin II receptor antagonist, increases angiotensin I and angiotensin II release from isolated rat hind legs: evidence for locally regulated renin-angiotensin system in vascular tissue.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Vessels; Hindlimb; Imidazoles; Losartan; Male; Muscle, Smooth, Vascular; Nephrectomy; Perfusion; Rats; Renin-Angiotensin System; Tetrazoles; Time Factors | 1992 |
Antihypertensive activity of the non-peptide angiotensin II receptor antagonist, SK&F 108566, in rats and dogs.
Topics: Acrylates; Angiotensin I; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Dogs; Hemodynamics; Hypertension; Imidazoles; Losartan; Male; Rats; Rats, Inbred Strains; Tetrazoles; Thiophenes | 1992 |
Angiotensin-II receptor subtypes in fetal tissue of the rat: autoradiography, guanine nucleotide sensitivity, and association with phosphoinositide hydrolysis.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding, Competitive; Fetus; Gestational Age; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Imidazoles; Losartan; Oligopeptides; Phosphatidylinositols; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles; Tissue Distribution | 1991 |
Angiotensin-II activation of cAMP and corticosterone production in bovine adrenocortical cells: effects of nonpeptide angiotensin-II antagonists.
Topics: Adrenal Cortex; Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Cattle; Corticosterone; Cyclic AMP; Imidazoles; Losartan; Pyridines; Saralasin; Tetrazoles | 1991 |
In vivo evaluation of the antagonist activity of angiotensin I analogs.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensins; Animals; Biphenyl Compounds; Captopril; Imidazoles; Losartan; Lung; Male; Peptide Fragments; Rats; Rats, Inbred Strains; Tetrazoles | 1992 |
Stimulation of endothelial cell prostaglandin production by angiotensin peptides. Characterization of receptors.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cells, Cultured; Dinoprostone; Endothelium, Vascular; Epoprostenol; Imidazoles; Losartan; Oligopeptides; Prostaglandins; Pyridines; Receptors, Angiotensin; Tetrazoles | 1992 |
Effects of angiotensin subtype 1 and subtype 2 receptor antagonists in normotensive versus hypertensive rats.
Topics: Aldosterone; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Hypertension; Imidazoles; Infusions, Intravenous; Losartan; Mesentery; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Receptors, Angiotensin; Tetrazoles; Vasoconstriction | 1991 |
Prolonged angiotensin II antagonism in spontaneously hypertensive rats. Hemodynamic and biochemical consequences.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Benzazepines; Biphenyl Compounds; Blood Pressure; Body Weight; Dose-Response Relationship, Drug; Hemodynamics; Imidazoles; Losartan; Male; Myocardium; Nephrectomy; Organ Size; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazoles; Time Factors | 1991 |
Effect of a nonpeptide angiotensin II receptor antagonist, DuP 753, on angiotensin-related water intake in rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cerebral Ventricles; Drinking Behavior; Imidazoles; Injections, Intraventricular; Injections, Subcutaneous; Losartan; Male; Mice; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Reference Values; Tetrazoles; Time Factors | 1991 |
Characterization of angiotensin receptors mediating prostaglandin synthesis in C6 glioma cells.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Glioma; Imidazoles; Losartan; Oligopeptides; Peptide Fragments; Prostaglandins; Receptors, Angiotensin; Tetrazoles; Tumor Cells, Cultured | 1991 |
Effects of losartan on angiotensin and bradykinin peptides and angiotensin-converting enzyme.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Bradykinin; Imidazoles; Losartan; Male; Organ Specificity; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Tetrazoles | 1995 |
Regulation of luminal alkalinization and acidification in the cortical collecting duct by angiotensin II.
Topics: Acids; Alkalies; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Bicarbonates; Biphenyl Compounds; Female; Hydrogen-Ion Concentration; Imidazoles; In Vitro Techniques; Kidney Tubules, Collecting; Losartan; Osmolar Concentration; Perfusion; Rabbits; Tetrazoles | 1995 |
Different effects of angiotensin-converting enzyme inhibition in human arteries and veins.
Topics: Acetylcholine; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Compounds; Bradykinin; Enalaprilat; Endothelium, Vascular; Humans; Imidazoles; In Vitro Techniques; Losartan; Mammary Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Saphenous Vein; Tetrazoles | 1993 |
Role of angiotensin in pressure overload-induced hypertrophy in rats: effects of angiotensin-converting enzyme inhibitors, an AT1 receptor antagonist, and surgical reversal.
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Abdominal; Biphenyl Compounds; Blood Pressure; Body Weight; Cardiomegaly; Enalapril; Heart Ventricles; Imidazoles; Losartan; Male; Organ Size; Ramipril; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Tetrazoles; Ventricular Function | 1994 |
Angiotensin-(1-7) and nitric oxide interaction in renovascular hypertension.
Topics: Amino Acid Oxidoreductases; Angiotensin I; Angiotensin II; Angiotensins; Animals; Arginine; Biphenyl Compounds; Dogs; Hemodynamics; Hypertension, Renovascular; Imidazoles; Lisinopril; Losartan; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Peptidyl-Dipeptidase A; Tetrazoles | 1995 |
Identification of atypical (non-AT1, non-AT2) angiotensin binding sites with high affinity for angiotensin I on IEC-18 rat intestinal epithelial cells.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Binding Sites; Binding, Competitive; Biphenyl Compounds; Cell Line; Epithelium; Imidazoles; Intestinal Mucosa; Intestine, Small; Losartan; Oligopeptides; Peptide Fragments; Pyridines; Rats; Receptors, Angiotensin; Tetrazoles | 1995 |
Comparison of the transplacental transfer of enalapril, captopril and losartan in sheep.
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Animals; Biological Transport; Biphenyl Compounds; Blood Pressure; Captopril; Enalapril; Female; Fetus; Imidazoles; Injections, Intravenous; Losartan; Placenta; Sheep; Tetrazoles | 1995 |
Sympathetic nerve activity in conscious renal hypertensive rats treated with an angiotensin converting enzyme inhibitor or an angiotensin II antagonist.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Heart Rate; Hypertension, Renal; Imidazoles; Lisinopril; Losartan; Male; Nitroprusside; Rats; Rats, Wistar; Renin-Angiotensin System; Splanchnic Nerves; Sympathetic Nervous System; Tetrazoles | 1995 |
Differential responses to angiotensin-(1-7) in the feline mesenteric and hindquarters vascular beds.
Topics: Amino Acid Oxidoreductases; Angiotensin I; Angiotensin II; Angiotensin III; Animals; Arginine; Biphenyl Compounds; Cats; Hindlimb; Imidazoles; Losartan; Meclofenamic Acid; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptide Fragments; Perfusion; Tetrazoles; Vascular Resistance; Vasoconstriction | 1993 |
Systemic and coronary effects of the angiotensin II receptor antagonist EXP3174 in dogs.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Coronary Circulation; Dogs; Enalaprilat; Female; Furosemide; Hemodynamics; Imidazoles; Losartan; Male; Renin-Angiotensin System; Tetrazoles | 1993 |
Angiotensin(1-7) is an antagonist at the type 1 angiotensin II receptor.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Imidazoles; In Vitro Techniques; Losartan; Male; Peptide Fragments; Rabbits; Rats; Rats, Sprague-Dawley; Tetrazoles | 1994 |
Prevention of angiotensin II induced myocyte necrosis and coronary vascular damage by lisinopril and losartan in the rat.
Topics: Angiotensin I; Angiotensin II; Animals; Biphenyl Compounds; Coronary Vessels; Dose-Response Relationship, Drug; Heart; Hypertension, Renovascular; Imidazoles; Lisinopril; Losartan; Male; Necrosis; Rats; Rats, Sprague-Dawley; Tetrazoles | 1995 |
BMS-180560, an insurmountable inhibitor of angiotensin II-stimulated responses: comparison with losartan and EXP3174.
Topics: Adrenal Cortex; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Extracellular Space; Imidazoles; In Vitro Techniques; Losartan; Male; Membranes; Muscle Contraction; Muscle, Smooth, Vascular; Phosphatidylinositols; Rabbits; Rats; Tetrazoles | 1994 |
Angiotensin 1-7 has a biphasic effect on fluid absorption in the proximal straight tubule.
Topics: Adsorption; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Bicarbonates; Biphenyl Compounds; Imidazoles; In Vitro Techniques; Ion Transport; Kidney Tubules, Proximal; Kinetics; Losartan; Male; Peptide Fragments; Perfusion; Permeability; Pyridines; Rats; Rats, Sprague-Dawley; Tetrazoles | 1994 |
The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Base Sequence; Binding, Competitive; Biphenyl Compounds; Cell Division; Cells, Cultured; Coronary Vessels; DNA; DNA Primers; Dose-Response Relationship, Drug; Endothelium, Vascular; Gene Expression; Imidazoles; Kinetics; Losartan; Molecular Sequence Data; Muscle, Smooth, Vascular; Oligopeptides; Polymerase Chain Reaction; Pyridines; Rats; Receptors, Angiotensin; RNA, Messenger; Tetrazoles; Thymidine | 1995 |
Evidence that angiotensin-(1-7) plays a role in the central control of blood pressure at the ventro-lateral medulla acting through specific receptors.
Topics: Analysis of Variance; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Imidazoles; Losartan; Male; Medulla Oblongata; Oligopeptides; Peptide Fragments; Rats; Rats, Wistar; Tetrazoles | 1994 |
Subtype 2 of angiotensin II receptors controls pressure-natriuresis in rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Diuresis; Glomerular Filtration Rate; Imidazoles; Losartan; Male; Natriuresis; Oligopeptides; Perfusion; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renal Circulation; Tetrazoles | 1995 |
Angiotensins induce the release of prostacyclin from rabbit vas deferens: evidence for receptor heterogeneity.
Topics: 6-Ketoprostaglandin F1 alpha; Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Epoprostenol; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle, Smooth; Pyridines; Rabbits; Receptors, Angiotensin; Tetrazoles; Vas Deferens | 1994 |
Comparative pharmacology of recombinant rat AT1A, AT1B and human AT1 receptors expressed by transfected COS-M6 cells.
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Biphenyl Compounds; Cell Line; DNA, Complementary; Humans; Imidazoles; Losartan; Membranes; Plasmids; Polymerase Chain Reaction; Radioligand Assay; Rats; Receptors, Angiotensin; Recombinant Proteins; Tetrazoles; Transfection | 1994 |
AT1 receptor characteristics of angiotensin analogue binding in human synovium.
Topics: Adult; Aged; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Arthritis, Rheumatoid; Autoradiography; Biphenyl Compounds; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Imidazoles; Immunohistochemistry; In Vitro Techniques; Iodine Radioisotopes; Ligands; Losartan; Male; Middle Aged; Osteoarthritis; Pyridines; Receptors, Angiotensin; Synovial Fluid; Tetrazoles | 1994 |
Evidence for direct local effect of angiotensin in vascular hypertrophy. In vivo gene transfer of angiotensin converting enzyme.
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Carotid Arteries; DNA; Endothelium, Vascular; Gene Transfer Techniques; Genetic Vectors; Heart Rate; Humans; Hypertrophy; Imidazoles; Immunohistochemistry; Liposomes; Losartan; Male; Muscle, Smooth, Vascular; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Reference Values; Tetrazoles; Transfection | 1994 |
Effects of angiotensin II and angiotensin-(1-7) on the release of [3H]norepinephrine from rat atria.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Drug Interactions; Electric Stimulation; Female; Heart; Heart Atria; Imidazoles; Losartan; Myocardium; Norepinephrine; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Saralasin; Tetrazoles | 1994 |
Positive inotropic action of angiotensin II in the pithed rat.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Decerebrate State; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Losartan; Male; Myocardial Contraction; Pyridines; Rats; Rats, Wistar; Stimulation, Chemical; Tetrazoles | 1993 |
Role of angiotensin AT1 receptor in the cardiovascular response to footshock.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Electroshock; Heart Rate; Hemodynamics; Imidazoles; Losartan; Male; Norepinephrine; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1994 |
ANG II receptor expression and function during phenotypic modulation of rat aortic smooth muscle cells.
Topics: Actins; Angiotensin I; Angiotensin III; Animals; Aorta, Thoracic; Biphenyl Compounds; Calcium; Cattle; Cell Division; Cells, Cultured; Endothelium, Vascular; Imidazoles; Inositol 1,4,5-Trisphosphate; Kinetics; Losartan; Male; Muscle, Smooth, Vascular; Phenotype; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles | 1994 |
Analysis of angiotensins I, II, and III in pulmonary vascular bed of the rat.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Blood Vessels; Captopril; Enalaprilat; Imidazoles; In Vitro Techniques; Losartan; Male; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Tetrazoles | 1994 |
Selective changes in angiotensin II AT1 and AT2 receptor subtypes in the rat superior colliculus following eye enucleation.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Biphenyl Compounds; Eye Enucleation; Geniculate Bodies; Imidazoles; Iodine Radioisotopes; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Retina; Saralasin; Subcellular Fractions; Superior Colliculi; Suprachiasmatic Nucleus; Synapses; Tetrazoles; Visual Pathways | 1994 |
Angiotensin II increases norepinephrine release from atria by acting on angiotensin subtype 1 receptors.
Topics: Analysis of Variance; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Guinea Pigs; Heart; Heart Atria; Imidazoles; In Vitro Techniques; Kinetics; Losartan; Male; Myocardium; Norepinephrine; Ramipril; Receptors, Angiotensin; Tetrazoles | 1993 |
Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype.
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cattle; Female; Humans; Imidazoles; In Vitro Techniques; Losartan; Male; Rabbits; Rats; Receptors, Angiotensin; Tetrazoles; Valine; Valsartan | 1993 |
Characterization of cardiac angiotensin AT1 receptors by [3H]SR 47436.
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Biphenyl Compounds; Calcium; Cells, Cultured; Heart; Homeostasis; Imidazoles; Irbesartan; Kinetics; Losartan; Myocardium; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles | 1993 |
Oxytocic effect of trypsin on the isolated rat uterus.
Topics: Angiotensin I; Angiotensin II; Animals; Biphenyl Compounds; Bradykinin; Dose-Response Relationship, Drug; Enalaprilat; Female; Imidazoles; In Vitro Techniques; Isometric Contraction; Losartan; Oxytocin; Pepstatins; Rats; Saralasin; Tetrazoles; Trypsin; Uterine Contraction; Uterus | 1994 |
Chronic converting enzyme inhibition facilitates baroreceptor resetting to hypertensive levels.
Topics: Angiotensin I; Angiotensin II; Animals; Aorta; Biphenyl Compounds; Blood Pressure; Bradykinin; Captopril; Enalapril; Hypertension; Imidazoles; Losartan; Male; Pressoreceptors; Rats; Rats, Wistar; Reference Values; Regression Analysis; Tetrazoles | 1994 |
Comparison of the effects of EXP3174, an angiotensin II antagonist and enalaprilat on myocardial infarct size in anaesthetized dogs.
Topics: Anesthesia; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Coronary Circulation; Disease Models, Animal; Dogs; Enalaprilat; Female; Furosemide; Heart Rate; Imidazoles; Injections, Intravenous; Losartan; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Renin-Angiotensin System; Tetrazoles | 1993 |
The effect of the putative AT2 agonist, p-aminophenylalanine6 angiotensin II, on thirst and sodium appetite in rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Appetite; Biphenyl Compounds; Drinking; Imidazoles; Injections, Intraventricular; Losartan; Male; Oligopeptides; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Sodium Chloride, Dietary; Tetrazoles; Thirst | 1993 |
Effect of nonpeptide angiotensin AT-1 and AT-2 antagonists on isoproterenol-induced renin release.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Imidazoles; Injections, Intraventricular; Isoproterenol; Losartan; Male; Potassium; Pyridines; Rats; Rats, Sprague-Dawley; Renin; Tetrazoles | 1993 |
Functional role of brain AT1 and AT2 receptors in the central angiotensin II pressor response.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Brain; Chlorisondamine; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Injections, Intraventricular; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renal Circulation; Tetrazoles | 1993 |
Regulation of vascular angiotensin release.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Animals; Aorta; Base Sequence; Biphenyl Compounds; Dexamethasone; Ethinyl Estradiol; Hindlimb; Imidazoles; Losartan; Male; Molecular Sequence Data; Muscle, Smooth, Vascular; Muscles; Nephrectomy; Oligodeoxyribonucleotides; Perfusion; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Renin; RNA, Messenger; Tetrazoles; Triiodothyronine | 1993 |
Comparison of the regional haemodynamic effects of the AT1-receptor antagonists, losartan and EXP 3174, in water-deprived Brattleboro rats.
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Hemodynamics; Imidazoles; Losartan; Male; Rats; Rats, Brattleboro; Regional Blood Flow; Tetrazoles; Time Factors; Water Deprivation | 1993 |
Binding and signal transduction of the cloned vascular angiotensin II (AT1a) receptor cDNA stably expressed in Chinese hamster ovary cells.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Adenylyl Cyclases; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding Sites; Biphenyl Compounds; Calcium; CHO Cells; Cloning, Molecular; Cricetinae; DNA; Imidazoles; Losartan; Pyridines; Radioligand Assay; Receptors, Angiotensin; Signal Transduction; Tetrazoles; Transfection | 1993 |
Characterization of angiotensin AT1A receptor isoform by its ligand binding signature.
Topics: Adrenal Cortex; Angiotensin I; Angiotensin III; Animals; Base Sequence; Binding, Competitive; Biphenyl Compounds; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Imidazoles; Losartan; Molecular Sequence Data; Muscle, Smooth, Vascular; Nicotinic Acids; Pyridines; Rats; Receptors, Angiotensin; Recombinant Proteins; Saralasin; Tetrazoles; Transfection | 1993 |
Chimeric renin-angiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes.
Topics: Angiotensin I; Angiotensin II; Angiotensinogen; Animals; Biphenyl Compounds; Blood Pressure; Captopril; Dipeptides; Humans; Imidazoles; Losartan; Male; Mice; Mice, Transgenic; Morpholines; Recombinant Proteins; Renin; Renin-Angiotensin System; Tetrazoles | 1993 |
Effects of des-Asp-angiotensin I on the electrically stimulated contraction of the rabbit pulmonary artery.
Topics: Angiotensin I; Animals; Antihypertensive Agents; Biphenyl Compounds; Electric Stimulation; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Pulmonary Artery; Pyridines; Rabbits; Synaptic Transmission; Tetrazoles; Vasoconstrictor Agents | 1995 |
Ramipril-induced decrease in renal lithium excretion in the rat.
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Blood Pressure; Creatinine; Imidazoles; Indomethacin; Kidney; Lithium; Losartan; Male; Ramipril; Rats; Rats, Wistar; Tetrazoles | 1995 |
Absence of a losartan interaction with renal lithium excretion in the rat.
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Biphenyl Compounds; Creatinine; Diuresis; Imidazoles; Indomethacin; Kidney; Lithium; Losartan; Male; Rats; Rats, Wistar; Tetrazoles; Urodynamics; Water-Electrolyte Balance | 1995 |
Anti-hypertensive therapy by losartan. How effective is AT1 receptor blockade?
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Renin-Angiotensin System; Tetrazoles | 1995 |
Characterization of contractile response to angiotensin in epididymal rat vas deferens.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Dose-Response Relationship, Drug; Electric Stimulation; Epididymis; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle Contraction; Muscle, Smooth; Oligopeptides; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Tetrazoles; Vas Deferens; Vasoconstrictor Agents | 1995 |
The effect of AT1 receptor antagonist on chronic cardiac response to coronary artery ligation in rats.
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Capillaries; Coronary Vessels; Heart; Imidazoles; Losartan; Male; Myocardial Infarction; Neovascularization, Physiologic; Rats; Rats, Sprague-Dawley; Tetrazoles; Ventricular Pressure | 1996 |
Subtypes of losartan-sensitive angiotensin receptor in the rabbit pulmonary artery.
Topics: Angiotensin I; Animals; Antihypertensive Agents; Biphenyl Compounds; Imidazoles; In Vitro Techniques; Indomethacin; Losartan; Muscle, Smooth, Vascular; Pulmonary Artery; Pyridines; Rabbits; Receptors, Angiotensin; Tetrazoles | 1996 |
Ability of angiotensin II to modulate striatal dopamine release via the AT1 receptor in vitro and in vivo.
Topics: Angiotensin I; Angiotensin II; Animals; Biphenyl Compounds; Corpus Striatum; Dopamine; Extracellular Space; Female; Imidazoles; In Vitro Techniques; Losartan; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles | 1996 |
The contribution of AT1 and AT2 angiotensin receptors to its cognitive effects.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Cognition; Imidazoles; Losartan; Oligopeptides; Rats; Receptors, Angiotensin; Tetrazoles | 1996 |
Gastric acid secretion after blockade of angiotensin AT1 receptors in the Na(+)-depleted rat.
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Extracellular Space; Gastric Acid; Gastric Mucosa; Imidazoles; Losartan; Male; Microspheres; Pentagastrin; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sodium; Tetrazoles; Tin Radioisotopes | 1995 |
Angiotensin type 1 receptor antagonists CV-11974 and EXP 3174 cause selective renal vasodilatation in conscious spontaneously hypertensive rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Tetrazoles; Vasodilation | 1996 |
Renin-angiotensin system in stretch-induced hypertrophy of cultured neonatal rat heart cells.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Animals; Antihypertensive Agents; Biphenyl Compounds; Captopril; Cardiomegaly; Cells, Cultured; Heart; Imidazoles; Losartan; Muscle Proteins; Muscle Spindles; Myocardium; Rats; Rats, Sprague-Dawley; Renin; Tetrazoles | 1996 |
Potentiation of purinergic transmission by angiotensin in prostatic rat vas deferens.
Topics: Adrenergic Uptake Inhibitors; Angiotensin I; Angiotensin II; Animals; Biphenyl Compounds; Electric Stimulation; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle Contraction; Norepinephrine; Oligopeptides; Prostate; Protease Inhibitors; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Reserpine; Synaptic Transmission; Tetrazoles; Vas Deferens | 1996 |
Pressor action of angiotensin I at the ventrolateral medulla: effect of selective angiotensin blockade.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Imidazoles; Losartan; Male; Medulla Oblongata; Microinjections; Peptide Fragments; Ramipril; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles | 1996 |
Modulation by locally produced luminal angiotensin II of proximal tubular sodium reabsorption via an AT1 receptor.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Imidazoles; Kidney Tubules, Proximal; Losartan; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Sodium; Tetrazoles | 1996 |
Renin secretion in conscious Lyon hypertensive rats.
Topics: Adrenergic beta-Agonists; Angiotensin I; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Hypertension; Imidazoles; Isoproterenol; Losartan; Male; Osmolar Concentration; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Renin; Tetrazoles | 1996 |
Angiotensin II, via an action at AT1 receptors, may modulate the behavioural effects of ET-1 in conscious rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Behavior, Animal; Biphenyl Compounds; Drug Synergism; Endothelin-1; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1996 |
Effect of angiotensin receptor blockade in the rabbit aorta: influence of the endothelium.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Biphenyl Compounds; Enalapril; Endothelium, Vascular; Imidazoles; Losartan; Male; Pyridines; Rabbits; Receptors, Angiotensin; Tetrazoles | 1996 |
Angiotensin II activates distinct signal transduction pathways in astrocytes isolated from neonatal rat brain.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Astrocytes; Biphenyl Compounds; Bradykinin; Brain; Cells, Cultured; Cerebellum; Cerebral Cortex; Epoprostenol; Humans; Hypothalamus; Imidazoles; Losartan; Medulla Oblongata; Peptide Fragments; Phosphatidylinositol Diacylglycerol-Lyase; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetrazoles; Type C Phospholipases | 1997 |
Cardiovascular effects produced by microinjection of angiotensins and angiotensin antagonists into the ventrolateral medulla of freely moving rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Heart Rate; Imidazoles; Losartan; Male; Medulla Oblongata; Microinjections; Oligopeptides; Peptide Fragments; Rats; Rats, Wistar; Tetrazoles; Time Factors | 1997 |
Video-microscopic assessment of the role of tissue angiotensin-converting enzyme in the control of the renal microcirculation.
Topics: Angiotensin I; Angiotensin II; Animals; Arterioles; Biphenyl Compounds; Imidazoles; Indoles; Kidney; Losartan; Male; Microscopy, Video; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Tetrazoles; Vasoconstriction | 1997 |
In vivo angiotensin II receptor blockade and converting enzyme inhibition on canine aortic viscoelasticity.
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Dogs; Elasticity; Enalaprilat; Hypertension, Renovascular; Imidazoles; Losartan; Male; Reference Values; Tetrazoles; Viscosity | 1997 |
Losartan, a selective inhibitor of subtype AT1 receptors for angiotensin II, inhibits the binding of N-formylmethionyl-leucyl-phenylalanine to neutrophil receptors.
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Humans; Imidazoles; Losartan; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Receptors, Angiotensin; Tetrazoles | 1997 |
Atypical angiotensin II receptors coupled to phosphoinositide turnover/calcium signalling in catfish hepatocytes.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Biphenyl Compounds; Calcium; Cell Membrane; Egtazic Acid; Humans; Ictaluridae; Imidazoles; Liver; Losartan; Phosphatidylinositols; Pyridines; Receptors, Angiotensin; Signal Transduction; Tetrazoles | 1997 |
Characterization of the AT1 angiotensin II receptor expressed in guinea pig liver.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Binding, Competitive; Biphenyl Compounds; Enzyme Activation; Guinea Pigs; Imidazoles; Irbesartan; Liver; Losartan; Male; Polymerase Chain Reaction; Pyridines; Receptors, Angiotensin; RNA, Messenger; Tetrazoles | 1997 |
Role of angiotensin in the dipsogenic effect of bradykinin in rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Animals; Biphenyl Compounds; Bradykinin; Brain; Captopril; Cerebral Ventricles; Drinking; Imidazoles; Immunohistochemistry; Losartan; Male; Peptidyl-Dipeptidase A; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Renin; Tetrazoles; Thirst | 1997 |
[Angiotensin II antagonist for heart insufficiency].
Topics: Adrenergic beta-Antagonists; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Biphenyl Compounds; Heart Failure; Humans; Imidazoles; Losartan; Prognosis; Tetrazoles | 1997 |
Renal effects of an angiotensin II antagonist in stroke-prone spontaneously hypertensive rat.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Body Weight; Cerebrovascular Disorders; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Imidazoles; Kidney; Kidney Function Tests; Kidney Glomerulus; Losartan; Organ Size; Proteinuria; Rats; Rats, Inbred SHR; Receptors, Angiotensin; Tetrazoles; Tissue Embedding | 1997 |
In vitro pharmacological properties of KRH-594, a novel angiotensin II type 1 receptor antagonist.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Guinea Pigs; Ileum; In Vitro Techniques; Losartan; Male; Muscle Contraction; Rabbits; Tetrazoles; Thiadiazoles; Vasoconstrictor Agents | 1997 |
Angiotensin-(1-7) and the rat aorta: modulation by the endothelium.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Animals; Antihypertensive Agents; Aorta, Thoracic; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin | 1997 |
Pharmacological profiles of a novel non-peptide angiotensin II type I receptor antagonist HR720 in vitro and in vivo.
Topics: Adrenal Glands; Adult; Aged; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cricetinae; Humans; Imidazoles; In Vitro Techniques; Losartan; Male; Mesocricetus; Middle Aged; Muscle, Smooth, Vascular; Rabbits; Rats; Tetrazoles; Thermodynamics | 1997 |
Angiotensin-(1-7) contributes to the antihypertensive effects of blockade of the renin-angiotensin system.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Bradykinin; Dipeptides; Heart Rate; Hypertension; Kinetics; Lisinopril; Losartan; Male; Neprilysin; Organophosphonates; Peptide Fragments; Peptides, Cyclic; Phenylalanine; Protease Inhibitors; Rats; Rats, Inbred SHR; Renin-Angiotensin System | 1998 |
Vasodepressor actions of angiotensin-(1-7) unmasked during combined treatment with lisinopril and losartan.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antibodies, Monoclonal; Antihypertensive Agents; Blood Pressure; Heart Rate; Imidazoles; Immunoglobulin G; Lisinopril; Losartan; Male; Mice; Mice, Inbred BALB C; Peptide Fragments; Pyridines; Rats; Rats, Inbred SHR; Vasodilation | 1998 |
Pulmonary edema induced by angiotensin I in rats.
Topics: Adrenergic alpha-Antagonists; Angiotensin I; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Epinephrine; Losartan; Nitroglycerin; Phentolamine; Pulmonary Edema; Rats; Rats, Wistar; Receptors, Angiotensin; Regression Analysis; Respiration; Vasodilator Agents | 1998 |
HPLC assays to simultaneously determine the angiotensin-AT1 antagonist losartan as well as its main and active metabolite EXP 3174 in biological material of humans and rats.
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Chromatography, High Pressure Liquid; Humans; Imidazoles; Losartan; Rats; Receptors, Angiotensin; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Tetrazoles; Tissue Distribution | 1998 |
The receptor subtype mediating the action of angiotensin II on intracellular sodium in rat proximal tubules.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Extracellular Space; Imidazoles; In Vitro Techniques; Ion Transport; Kidney Tubules, Proximal; Losartan; Male; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Sodium | 1998 |
Renal uptake of circulating angiotensin II in Val5-angiotensin II infused rats is mediated by AT1 receptor.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Kidney; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin | 1998 |
Effects of the AT1 antagonist HR 720 in comparison to losartan on stimulated sympathetic outflow, blood pressure, and heart rate in pithed spontaneously hypertensive rats.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Catecholamines; Decerebrate State; Dose-Response Relationship, Drug; Electric Stimulation; Heart Rate; Hemodynamics; Hypertension; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Sympathetic Nervous System | 1998 |
[7-D-ALA]-angiotensin 1-7 blocks renal actions of angiotensin 1-7 in the anesthetized rat.
Topics: Anesthesia; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Kidney; Kidney Function Tests; Kidney Tubules, Proximal; Losartan; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Renal Circulation | 1998 |
Pouch tissue and angiotensin peptide generation.
Topics: Angiotensin I; Angiotensin II; Angiotensinogen; Angiotensins; Animals; Aspartic Acid Endopeptidases; Cathepsin D; Collagen; Gene Expression; Imidazoles; Lisinopril; Losartan; Myocardium; Peptide Biosynthesis; Peptides; Peptidyl-Dipeptidase A; Pyridines; Rats; Renin; Transforming Growth Factor beta | 1998 |
Converting enzyme determines plasma clearance of angiotensin-(1-7).
Topics: Administration, Oral; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Genetically Modified; Blood Pressure; Chromatography, High Pressure Liquid; Drug Combinations; Half-Life; Lisinopril; Losartan; Male; Metabolic Clearance Rate; Peptide Fragments; Radioimmunoassay; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Species Specificity | 1998 |
Angiotensin II receptor antagonists for heart failure.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Bradykinin; Captopril; Clinical Trials as Topic; Heart Failure; Humans; Losartan; Receptors, Angiotensin | 1998 |
Chronic effects of early started angiotensin converting enzyme inhibition and angiotensin AT1-receptor subtype blockade in rats with myocardial infarction: role of bradykinin.
Topics: Adrenergic beta-Antagonists; Analysis of Variance; Angiotensin I; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Bradykinin Receptor Antagonists; Dose-Response Relationship, Drug; Heart Ventricles; Hemodynamics; Hypertrophy, Left Ventricular; Isoquinolines; Losartan; Male; Myocardial Infarction; Organ Size; Quinapril; Rats; Rats, Wistar; Tetrahydroisoquinolines | 1998 |
Effect of selective angiotensin antagonists on the antidiuresis produced by angiotensin-(1-7) in water-loaded rats.
Topics: Analysis of Variance; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Diuresis; Drinking; Kidney; Losartan; Male; Peptide Fragments; Rats; Rats, Wistar; Receptors, Angiotensin; Renal Agents | 1998 |
The hyperglycemia induced by angiotensin II in rats is mediated by AT1 receptors.
Topics: Angiotensin I; Angiotensin II; Angiotensins; Animals; Antihypertensive Agents; Hyperglycemia; Losartan; Male; Rats; Rats, Wistar; Receptors, Angiotensin; Vasoconstrictor Agents | 1998 |
Roles of AT1 and AT2 receptors in the hypertensive Ren-2 gene transgenic rat kidney.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Genetically Modified; Blood Pressure; Heart Rate; Hemodynamics; Homozygote; Hypertension; Imidazoles; Kidney; Kidney Tubules; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reference Values; Renal Circulation; Renin | 1999 |
Analysis of responses to angiotensin I (3-10) and Leu3 angiotensin (3-8) in the pulmonary vascular bed of the cat.
Topics: Angiotensin I; Angiotensin II; Animals; Blood Pressure; Captopril; Cats; Dose-Response Relationship, Drug; Female; Imidazoles; Losartan; Male; Peptide Fragments; Pulmonary Artery; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 1998 |
Differential response of angiotensin peptides in the urine of hypertensive animals.
Topics: Administration, Oral; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Genetically Modified; Antihypertensive Agents; Blood Pressure; Body Weight; Drinking; Electrolytes; Hemodynamics; Hypertension; Lisinopril; Losartan; Male; Peptide Fragments; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley | 1999 |
Functional evidence for subfornical organ-intrinsic conversion of angiotensin I to angiotensin II.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Dose-Response Relationship, Drug; Drinking; Electrophysiology; Losartan; Male; Rats; Rats, Wistar; Reaction Time; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Subfornical Organ | 1999 |
Evidence for a causal role of the renin-angiotensin system in nitrate tolerance.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Bosentan; Dose-Response Relationship, Drug; Drug Tolerance; Endothelium, Vascular; Female; Gene Expression; Losartan; Luminescent Measurements; Male; Multienzyme Complexes; NADH, NADPH Oxidoreductases; NADPH Oxidases; Nitrates; Nitric Oxide; Nitroglycerin; Peptidyl-Dipeptidase A; Rabbits; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin; Renin-Angiotensin System; RNA, Messenger; Sulfonamides; Superoxides; Vasoconstriction; Vasodilation; Vasodilator Agents | 1999 |
Endothelin, but not angiotensin II, contributes to the hypoxic contractile response of large isolated pulmonary arteries in the rat.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Azepines; Bosentan; Calcium; Calcium Channel Blockers; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Extracellular Space; Glycopeptides; Hypoxia; In Vitro Techniques; Indoles; Lisinopril; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Pulmonary Artery; Rats; Rats, Wistar; Sulfonamides | 1999 |
Interactions between AT1 and AT2 receptors in uterine arteries from pregnant ewes.
Topics: Angiotensin I; Angiotensin II; Animals; Anti-Arrhythmia Agents; Arteries; Female; Hypersensitivity; In Vitro Techniques; Losartan; Muscle Contraction; Muscle, Smooth, Vascular; Pregnancy; Pregnancy, Animal; Receptors, Angiotensin; Sheep; Uterus | 1999 |
Differing effects of enalapril and losartan on renal medullary blood flow and renal interstitial hydrostatic pressure in spontaneously hypertensive rats.
Topics: Adrenergic beta-Antagonists; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Bradykinin; Enalapril; Hydrostatic Pressure; Kidney Medulla; Laser-Doppler Flowmetry; Losartan; Male; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renal Circulation | 1999 |
Renal responses to AT1 blockade in angiotensin II-induced hypertensive rats.
Topics: Analysis of Variance; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Glomerular Filtration Rate; Hypertension, Renal; Losartan; Male; Rats; Rats, Sprague-Dawley; Renal Circulation; Sodium | 1997 |
Angiotensin-(1-7) binds at the type 1 angiotensin II receptors in rat renal cortex.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding Sites; Imidazoles; Iodine Radioisotopes; Kidney Cortex; Losartan; Male; Peptide Fragments; Pyridines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Angiotensin | 1999 |
Losartan reduces the vasorelaxant effect of atrial natriuretic peptide on basal tone in aorta.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Atrial Natriuretic Factor; Calcium; Female; Imidazoles; In Vitro Techniques; Intracellular Fluid; Isotonic Solutions; Losartan; Male; Muscle, Smooth, Vascular; Pyridines; Rabbits; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Vascular Resistance; Vasodilation | 1999 |
Pharmacological characterization of KR-30988, a novel non-peptide AT1 receptor antagonist, in rat, rabbit and dog.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Dogs; Furosemide; Hypertension, Renal; Imidazoles; Losartan; Male; Oligopeptides; Pressoreceptors; Rabbits; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Recombinant Proteins; Tetrazoles; Vasoconstriction | 1999 |
The human renin infused rat: use as an in vivo model for the biological evaluation of human renin inhibitors.
Topics: Administration, Oral; Angiotensin I; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Dipeptides; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ganglionic Blockers; Humans; In Vitro Techniques; Losartan; Male; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Renin; Time Factors | 1999 |
The effects of angiotensin metabolites on the regulation of coagulation and fibrinolysis in cultured rat aortic endothelial cells.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Aorta; Blood Coagulation; Endothelium, Vascular; Fibrinolysis; Gene Expression Regulation; Imidazoles; Lipoproteins; Losartan; Plasminogen Activator Inhibitor 1; Pyridines; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Thromboplastin; Tissue Plasminogen Activator | 1999 |
Changes in angiotensin converting enzyme activity in the renal vascular bed of streptozotocin-induced diabetic rat.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Glucose; Captopril; Diabetes Mellitus, Experimental; Drug Interactions; Kidney; Losartan; Male; Muscle, Smooth, Vascular; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Renal Artery; Streptozocin; Vasoconstriction | 1999 |
Angiotensin III depressor action in the conscious rabbit is blocked by losartan but not PD 123319.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Imidazoles; Losartan; Male; Peptide Fragments; Pyridines; Rabbits; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 2000 |
AT1-receptor blockers.
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Heart Failure; Humans; Hypertension; Irbesartan; Losartan; Meta-Analysis as Topic; Tetrazoles; Valine; Valsartan | 2000 |
Effect of intrarenal infusion of angiotensin-(1-7) in the dog.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Diuresis; Dogs; Female; Glomerular Filtration Rate; Imidazoles; Infusions, Intra-Arterial; Kidney; Losartan; Male; Peptide Fragments; Receptors, Angiotensin; Renal Artery; Renal Circulation; Tetrazoles; Urodynamics; Vasodilator Agents | 2000 |
[Clinical efficacy of losartan: are there any differences between angiotensin II type I receptor antagonists and other drugs?].
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Humans; Hypertension; Losartan; Receptors, Angiotensin | 2000 |
Evidence that prostaglandins mediate the antihypertensive actions of angiotensin-(1-7) during chronic blockade of the renin-angiotensin system.
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Cyclooxygenase Inhibitors; Heart Rate; Lisinopril; Losartan; Male; Peptide Fragments; Prostaglandins; Rats; Rats, Inbred SHR; Receptors, Angiotensin; Renin-Angiotensin System | 2000 |
Renin angiotensin system of rabbit clitoral cavernosum: interaction with nitric oxide.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Clitoris; Culture Techniques; Female; Imidazoles; Losartan; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Pyridines; Rabbits; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2000 |
Angiotensin-(1-7) increases osmotic water permeability in isolated toad skin.
Topics: Analysis of Variance; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Anura; Humans; Losartan; Oxytocin; Peptide Fragments; Permeability; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Skin; Skin Absorption; Vasoconstrictor Agents; Vasotocin; Water | 2000 |
Interaction between AT1 and alpha1-adrenergic receptors in cardiomyopathic hamsters.
Topics: Angiotensin I; Animals; Antihypertensive Agents; Aorta; Cardiomyopathies; Cricetinae; Disease Models, Animal; Enalapril; Humans; Losartan; Male; Mesocricetus; Muscle Contraction; Muscle, Smooth, Vascular; Prazosin; Receptor Cross-Talk; Receptors, Adrenergic, alpha-1; Receptors, Angiotensin; Vascular Resistance | 2000 |
Effects of des-aspartate-angiotensin I on angiotensin II-induced incorporation of phenylalanine and thymidine in cultured rat cardiomyocytes and aortic smooth muscle cells.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Aorta, Thoracic; Cells, Cultured; DNA; Imidazoles; Indomethacin; Losartan; Muscle, Smooth, Vascular; Myocardium; Peptide Fragments; Phenylalanine; Protein Biosynthesis; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Thymidine | 2000 |
Contribution of circulating renin to local synthesis of angiotensin peptides in the heart.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Gene Expression Regulation; Humans; Losartan; Mice; Mice, Transgenic; Microscopy, Immunoelectron; Myocardium; Organ Specificity; Peptide Biosynthesis; Renin; Transgenes | 2000 |
Mitogen-activated protein kinase activity regulation role of angiotensin and endothelin systems in vascular smooth muscle cells.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Glycopeptides; Losartan; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Pepstatins; Peptides, Cyclic; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Renin | 2001 |
Mechanisms of angiotensin-(1-7)-induced inhibition of angiogenesis.
Topics: Analysis of Variance; Angiogenesis Inhibitors; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Imidazoles; Losartan; Male; Mice; Neovascularization, Pathologic; Neovascularization, Physiologic; Peptide Fragments; Prostheses and Implants; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2 | 2001 |
Angiotensin converting enzyme (ACE) and non-ACE dependent angiotensin II generation in resistance arteries from patients with heart failure and coronary heart disease.
Topics: Acetylcholine; Aged; Angina Pectoris; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Arteries; Bradykinin; Chymases; Enalaprilat; Female; Heart Failure; Humans; In Vitro Techniques; Losartan; Male; Middle Aged; Oligopeptides; Peptidyl-Dipeptidase A; Serine Endopeptidases; Vascular Resistance; Vasoconstriction | 2001 |
Sodium intake influences hemodynamic and neural responses to angiotensin receptor blockade in rostral ventrolateral medulla.
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Baroreflex; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Heart Failure; Heart Rate; Hemodynamics; Kidney; Losartan; Male; Medulla Oblongata; Microinjections; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin; Renin-Angiotensin System; Sodium, Dietary; Sympathetic Nervous System; Tetrazoles | 2001 |
Angiotensin II enhances noradrenaline release from sympathetic nerves of the rat prostate via a novel angiotensin receptor: implications for the pathophysiology of benign prostatic hyperplasia.
Topics: Analysis of Variance; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Captopril; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Imidazoles; Losartan; Male; Norepinephrine; Oligopeptides; Prostate; Prostatic Hyperplasia; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Sympathetic Nervous System; Synaptic Transmission | 2001 |
Effects of combined administration of ACE inhibitor and angiotensin II receptor antagonist are prevented by a high NaCl intake.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Behavior, Animal; Blood; Blood Pressure; Body Weight; Diet, Sodium-Restricted; Drug Synergism; Eating; Heart; Losartan; Organ Size; Perindopril; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Renin-Angiotensin System | 2001 |
Isoproterenol-induced cardiac hypertrophy: role of circulatory versus cardiac renin-angiotensin system.
Topics: Adrenergic beta-Agonists; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Collagen; Coronary Circulation; Heart Rate; Isoproterenol; Isoquinolines; Losartan; Male; Myocardium; Organ Size; Peptidyl-Dipeptidase A; Quinapril; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Renin; Renin-Angiotensin System; Tetrahydroisoquinolines | 2001 |
Angiotensin-(1-7) reverts the stimulatory effect of angiotensin II on the proximal tubule Na(+)-ATPase activity via a A779-sensitive receptor.
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Cell Membrane; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Kidney Tubules, Proximal; Losartan; Peptide Fragments; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Saralasin; Sodium-Potassium-Exchanging ATPase; Swine | 2002 |
The antithrombotic effect of angiotensin-(1-7) closely resembles that of losartan.
Topics: Angiotensin I; Animals; Antihypertensive Agents; Blood Pressure; Collagen; Fibrinolytic Agents; Hemostasis; Losartan; Male; Peptide Fragments; Platelet Adhesiveness; Rats; Rats, Inbred SHR; Rats, Wistar; Venous Thrombosis | 2000 |
Dysregulation of angiotensin II synthesis is associated with salt sensitivity in the spontaneous hypertensive rat.
Topics: Aldosterone; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Blood Pressure; Hypertension; Losartan; Male; Peptidyl-Dipeptidase A; Rats; Rats, Inbred SHR; Receptors, Angiotensin; Renin; Sodium Chloride, Dietary | 2002 |
Contribution of angiotensin II internalization to intrarenal angiotensin II levels in rats.
Topics: Angiotensin I; Angiotensin II; Angiotensinogen; Animals; Antihypertensive Agents; Diet, Sodium-Restricted; Kidney Cortex; Kidney Medulla; Losartan; Male; Peptidyl-Dipeptidase A; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Renin; Renin-Angiotensin System; Sodium Chloride, Dietary | 2002 |
Antithrombotic effect of captopril and losartan is mediated by angiotensin-(1-7).
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Epoprostenol; Fibrinolytic Agents; Hypertension, Renal; Imidazoles; Infusions, Intravenous; Losartan; Male; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Tetrazoles; Venous Thrombosis | 2002 |
AVE 0991, a nonpeptide mimic of the effects of angiotensin-(1-7) on the endothelium.
Topics: Angiotensin I; Animals; Binding, Competitive; Cattle; Cells, Cultured; Cricetinae; Electrochemistry; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Losartan; Molecular Mimicry; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Peptide Fragments; Pyridines; Radioligand Assay; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Substrate Specificity; Superoxides; Tetrazoles | 2002 |
Angiotensin receptors contribute to blood pressure homeostasis in salt-depleted SHR.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Homeostasis; Imidazoles; Immune Sera; Losartan; Male; Pyridines; Rats; Rats, Inbred SHR; Receptors, Angiotensin; Sodium; Time Factors | 2003 |
ACE and non-ACE mediated effect of angiotensin I on intracellular calcium mobilization in rat glomerular arterioles.
Topics: Algorithms; Angiotensin I; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arterioles; Calcium; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; In Vitro Techniques; Juxtaglomerular Apparatus; Kidney Glomerulus; Lisinopril; Losartan; Muscle, Smooth; Peptidyl-Dipeptidase A; Rats; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Renal Circulation; Serine Proteinase Inhibitors; Spectrometry, Fluorescence | 2003 |
Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bleeding Time; Captopril; Disease Models, Animal; Endothelium, Vascular; Female; Hemodynamics; Losartan; Myocardial Infarction; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Refractory Period, Electrophysiological; Vasodilation; Ventricular Fibrillation | 2003 |
Biphasic effects of angiotensin (1-7) and its interactions with angiotensin II in rat aorta.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Aorta, Thoracic; Drug Interactions; Imidazoles; In Vitro Techniques; Losartan; Male; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2003 |
Angioedema and AT1 receptor blockers: proceed with caution.
Topics: Angioedema; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Humans; Losartan | 2003 |
Activation and functional significance of the renin-angiotensin system in mice with cardiac restricted overexpression of tumor necrosis factor.
Topics: Age Factors; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Animals; Body Weight; Cardiomegaly; Collagen; Hemodynamics; Losartan; Mice; Mice, Transgenic; Myocardium; Organ Size; Organ Specificity; Peptidyl-Dipeptidase A; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin; Renin-Angiotensin System; RNA, Messenger; Tumor Necrosis Factor-alpha; Ventricular Remodeling | 2003 |
[Dosage equivalents of AT1-receptor antagonists available in Germany].
Topics: Acrylates; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Clinical Trials as Topic; Germany; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Olmesartan Medoxomil; Placebos; Telmisartan; Tetrazoles; Therapeutic Equivalency; Thiophenes; Time Factors; Valine; Valsartan | 2003 |
The role of Ang (1-7) in mediating the chronic hypotensive effects of losartan in normal rats.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Chronic Disease; Drug Interactions; Heart Rate; Hypotension; Losartan; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley | 2003 |
Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Carboxypeptidases; Cardiomyopathy, Hypertrophic; Coronary Vessels; Disease Models, Animal; Enzyme Induction; Imidazoles; Ligation; Losartan; Male; Myocardial Infarction; Myocardium; Olmesartan Medoxomil; Peptide Fragments; Peptidyl-Dipeptidase A; Pyridines; Rats; Rats, Inbred Lew; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; RNA, Messenger; Tetrazoles; Ventricular Remodeling | 2004 |
Angiotensin type-1 receptor blockade increases ACE 2 expression in the heart.
Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Carboxypeptidases; Down-Regulation; Enzyme Induction; Heart; Humans; Imidazoles; Losartan; Mice; Myocardial Infarction; Myocardium; Olmesartan Medoxomil; Peptide Fragments; Peptidyl-Dipeptidase A; Pyridines; Rats; Rats, Inbred Lew; Tetrazoles | 2004 |
Tonic angiotensinergic inputs to neurons in the anterior hypothalamic area of rats.
Topics: Acetylcholine; Action Potentials; Adrenergic alpha-Agonists; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Animals; Anterior Hypothalamic Nucleus; Anti-Arrhythmia Agents; Captopril; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Imidazoles; Losartan; Male; Muscarinic Antagonists; Neurons; Phenylephrine; Pyridines; Rats; Rats, Wistar; Scopolamine | 2004 |
Angiotensin II and angiotensin-(1-7) inhibit the inner cortex Na+ -ATPase activity through AT2 receptor.
Topics: Adjuvants, Immunologic; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Antihypertensive Agents; Cholera Toxin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Imidazoles; Kidney Cortex; Losartan; Peptide Fragments; Pertussis Toxin; Pyridines; Receptor, Angiotensin, Type 2; Sodium-Potassium-Exchanging ATPase; Swine; Vasoconstrictor Agents | 2004 |
Differential response of human cardiac fibroblasts to angiotensin I and angiotensin II.
Topics: Angiotensin I; Angiotensin II; Captopril; Cell Line; Collagen; Fibroblasts; Humans; Losartan; Myocardium; Peptidyl-Dipeptidase A | 2004 |
Intracellular and extracellular angiotensin II enhance the L-type calcium current in the failing heart.
Topics: Adenosine Triphosphatases; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Animals; Calcium Channels, L-Type; Calcium Signaling; Cardiomyopathies; Cells, Cultured; Cricetinae; Enalaprilat; Enzyme Activation; Extracellular Fluid; Intracellular Fluid; Losartan; Male; Mesocricetus; Myocytes, Cardiac; Protein Kinase C; Sarcoplasmic Reticulum; Staurosporine; Thapsigargin | 2004 |
Angiotensin II receptor modulation of renal vascular resistance and neurotransmission in young and adult spontaneously hypertensive rats.
Topics: Aging; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Imidazoles; Kidney; Losartan; Male; Norepinephrine; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WF; Receptor, Angiotensin, Type 1; Signal Transduction; Sympathetic Nervous System; Tetrazoles; Vascular Resistance; Vasoconstrictor Agents | 2005 |
Pharmacological concentration of angiotensin-(1-7) activates NADPH oxidase after ischemia-reperfusion in rat heart through AT1 receptor stimulation.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Enzyme Activation; Heart; In Vitro Techniques; Losartan; Male; Myocardial Ischemia; Myocardium; NADPH Oxidases; Peptide Fragments; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Reperfusion | 2005 |
Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Carboxypeptidases; Gene Expression Regulation; Lisinopril; Losartan; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Rats, Inbred Lew; RNA, Messenger | 2005 |
Evidence for a functional interaction of the angiotensin-(1-7) receptor Mas with AT1 and AT2 receptors in the mouse heart.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Drug Synergism; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Indomethacin; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; NG-Nitroarginine Methyl Ester; Peptide Fragments; Perfusion; Pressure; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Vasoconstrictor Agents | 2005 |
Distinct roles for ANG II and ANG-(1-7) in the regulation of angiotensin-converting enzyme 2 in rat astrocytes.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Antihypertensive Agents; Astrocytes; Carboxypeptidases; Cells, Cultured; Cerebellum; Female; Gene Expression Regulation; Imidazoles; Losartan; Medulla Oblongata; Peptide Fragments; Peptidyl-Dipeptidase A; Pregnancy; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetrazoles; Valine; Valsartan; Vasoconstrictor Agents | 2006 |
Effects of renin-angiotensin system blockade on renal angiotensin-(1-7) forming enzymes and receptors.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Carboxypeptidases; Gene Expression Regulation, Enzymologic; Hypertension, Renal; Kidney; Lisinopril; Losartan; Male; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Rats, Inbred Lew; Receptors, Angiotensin; Renin-Angiotensin System | 2005 |
Pressor responses to alligator Angiotensin I and some analogs in the spectacled caiman (Caiman crocodilus).
Topics: Alligators and Crocodiles; Angiotensin I; Angiotensin II; Angiotensin III; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Dose-Response Relationship, Drug; Epinephrine; Losartan; Male; Norepinephrine | 2006 |
Effect of angiotensin II blockade on a new congenic model of hypertension derived from transgenic Ren-2 rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Congenic; Animals, Genetically Modified; Crosses, Genetic; Hypertension, Renal; Kinetics; Lisinopril; Losartan; Male; Models, Genetic; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Rats, Inbred Lew; Renin; Renin-Angiotensin System; RNA, Messenger; Time Factors | 2006 |
Phosphoinositide hydrolysis increase by angiotensin-(1--7) in neonatal rat brain.
Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Antihypertensive Agents; Cerebral Cortex; Female; Hydrolysis; Losartan; Male; Peptide Fragments; Phosphatidylinositols; Rats; Rats, Inbred BB; Signal Transduction | 2007 |
Identification of a novel non-AT1, non-AT2 angiotensin binding site in the rat brain.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Autoradiography; Binding, Competitive; Brain; Drug Interactions; Imidazoles; Iodine Isotopes; Losartan; p-Chloromercuribenzoic Acid; Pyridines; Rats; Rats, Sprague-Dawley | 2007 |
Angiotensin-(3-7) pressor effect at the rostral ventrolateral medulla.
Topics: Anesthetics, Intravenous; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Losartan; Male; Medulla Oblongata; Microinjections; Peptide Fragments; Pulsatile Flow; Rats; Rats, Wistar; Urethane | 2007 |
Angiotensin-(1 7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: role of the AT1 and Mas receptors.
Topics: Androstadienes; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Dose-Response Relationship, Drug; Insulin; Insulin Receptor Substrate Proteins; Janus Kinase 2; Losartan; Male; Myocardium; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Signal Transduction; Tyrphostins; Wortmannin | 2007 |
Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production.
Topics: Acetophenones; Allopurinol; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Drug Antagonism; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Indomethacin; Losartan; Male; NADH, NADPH Oxidoreductases; NG-Nitroarginine Methyl Ester; Onium Compounds; Peptide Fragments; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Superoxides | 2007 |
Angiotensin-(1-7) inhibits in vitro endothelial cell tube formation in human umbilical vein endothelial cells through the AT(1-7) receptor.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Antihypertensive Agents; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Imidazoles; Losartan; Neovascularization, Physiologic; Peptide Fragments; Pyridines; Receptors, Angiotensin; Umbilical Veins; Vasoconstrictor Agents | 2007 |
Assessment of brain AT1-receptor on the nocturnal basal and angiotensin-induced thirst and sodium appetite in ovariectomised rats.
Topics: Administration, Oral; Angiotensin I; Angiotensin II; Angiotensins; Animals; Antihypertensive Agents; Appetite; Brain; Circadian Rhythm; Darkness; Drinking; Estrogens; Female; Injections, Intraventricular; Losartan; Ovariectomy; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Sodium; Thirst | 2007 |
Angiotensin II relaxations of bovine adrenal cortical arteries: role of angiotensin II metabolites and endothelial nitric oxide.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenal Cortex; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin III; Animals; Arteries; Cattle; Endothelium, Vascular; Imidazoles; Losartan; Nitric Oxide; Peptide Fragments; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2008 |
Involvement of AT(1) angiotensin receptors in the vasomodulatory effect of des-aspartate-angiotensin I in the rat renal vasculature.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Diabetes Mellitus, Experimental; Kidney; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1 | 2008 |
Regulation of ACE2 in cardiac myocytes and fibroblasts.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Animals, Newborn; Atrial Natriuretic Factor; Butadienes; Cells, Cultured; Endothelin-1; Fibroblasts; Flavonoids; Gene Expression Regulation, Enzymologic; Heart Ventricles; Losartan; Mitogen-Activated Protein Kinase 1; Myocytes, Cardiac; Nitriles; Peptide Fragments; Peptidyl-Dipeptidase A; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction | 2008 |
Defects in cutaneous angiotensin-converting enzyme 2 and angiotensin-(1-7) production in postural tachycardia syndrome.
Topics: Adolescent; Adult; Angiotensin I; Angiotensin-Converting Enzyme 2; Female; Humans; Losartan; Male; Nitroarginine; Peptide Fragments; Peptidyl-Dipeptidase A; Postural Orthostatic Tachycardia Syndrome; Skin; Vasodilation | 2009 |
The uterine placental bed Renin-Angiotensin system in normal and preeclamptic pregnancy.
Topics: Alanine; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Down-Regulation; Female; Gene Expression; Humans; Imidazoles; Losartan; Peptide Fragments; Peptidyl-Dipeptidase A; Placenta; Pre-Eclampsia; Pregnancy; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Stereoisomerism; Uterus | 2009 |
Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Bradycardia; Heart Rate; Hypertension; Losartan; Male; Medulla Oblongata; Microinjections; Peptide Fragments; Rats; Rats, Inbred F344 | 2009 |
Angiotensin II up-regulates CX3CR1 expression in THP-1 monocytes: impact on vascular inflammation and atherogenesis.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Atherosclerosis; Cell Adhesion; Cell Movement; Chemokine CX3CL1; CX3C Chemokine Receptor 1; Endothelial Cells; Gene Expression Regulation; Humans; Inflammation; Jurkat Cells; Losartan; Monocytes; Receptors, CCR5; Receptors, Chemokine; Receptors, CXCR4; Vasculitis; Vasoconstrictor Agents | 2010 |
Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme 2; Animals; Blotting, Western; Enzyme Inhibitors; Female; Imidazoles; Kidney Cortex; Leucine; Losartan; Peptide Fragments; Peptidyl-Dipeptidase A; Pyridines; Reactive Oxygen Species; Receptors, Angiotensin; Sheep; Time Factors | 2010 |
Angiotensin-(1-7) and angiotension II in the rostral ventrolateral medulla modulate the cardiac sympathetic afferent reflex and sympathetic activity in rats.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Losartan; Male; Medulla Oblongata; Peptide Fragments; Rats; Rats, Sprague-Dawley | 2010 |
Astroglia are a possible cellular substrate of angiotensin(1-7) effects in the rostral ventrolateral medulla.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Astrocytes; Biosensing Techniques; Blood Pressure; Calcium Signaling; Catecholamines; Disease Models, Animal; Genes, Reporter; Hypertension; Losartan; Medulla Oblongata; Membrane Potentials; Microscopy, Confocal; Patch-Clamp Techniques; Peptide Fragments; Rats; Rats, Inbred SHR; Rats, Wistar; Tissue Culture Techniques | 2010 |
Effect of ACE2 and angiotensin-(1-7) in a mouse model of early chronic kidney disease.
Topics: Albuminuria; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Body Weight; Chronic Disease; Disease Models, Animal; Glomerular Filtration Rate; Hematocrit; Imidazoles; Infusion Pumps; Injections, Subcutaneous; Inulin; Kidney; Kidney Diseases; Leucine; Losartan; Male; Mice; Nephrectomy; Organ Size; Peptide Fragments; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Time Factors | 2010 |
Vitamin D receptor attenuates renal fibrosis by suppressing the renin-angiotensin system.
Topics: Angiotensin I; Animals; Cells, Cultured; Chemokine CCL2; Collagen Type I; Connective Tissue Growth Factor; Disease Models, Animal; Fibronectins; Fibrosis; Kidney; Kidney Diseases; Losartan; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Calcitriol; Renin-Angiotensin System; Transforming Growth Factor beta | 2010 |
Angiotensin-(1-7) and low-dose angiotensin II infusion reverse salt-induced endothelial dysfunction via different mechanisms in rat middle cerebral arteries.
Topics: Acetylcholine; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cerebral Arterial Diseases; Cerebral Arteries; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Imidazoles; Infusions, Intravenous; Losartan; Male; Nitroprusside; Peptide Fragments; Pyridines; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Superoxides; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2010 |
Protective actions of des-aspartate-angiotensin I in mice model of CEES-induced lung intoxication.
Topics: Angiotensin I; Animals; Bronchoalveolar Lavage Fluid; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Epoprostenol; Intercellular Adhesion Molecule-1; Losartan; Lung; Male; Mice; Mice, Inbred BALB C; Mustard Gas; NADPH Oxidases; Peroxidase; Reactive Oxygen Species; Receptors, Immunologic; Signal Transduction | 2011 |
Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Atherosclerosis; Bone Marrow Cells; Bone Marrow Transplantation; Cell Adhesion; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; Cytokines; Dietary Fats; Disease Models, Animal; Endothelial Cells; Humans; Inflammation Mediators; Losartan; Macrophages; Male; Mice; Mice, Knockout; Monocytes; Peptide Fragments; Peptidyl-Dipeptidase A; Receptors, LDL | 2011 |
Evidence of an intracellular angiotensin-generating system and non-AT1, non-AT2 binding site in a human pancreatic cell line.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Binding Sites; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Humans; Intracellular Space; Losartan; Pancreatic Neoplasms; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Vascular Endothelial Growth Factor A | 2011 |
Des-aspartate-angiotensin-I and angiotensin IV improve glucose tolerance and insulin signalling in diet-induced hyperglycaemic mice.
Topics: Angiotensin I; Angiotensin II; Animals; Blood Glucose; Cystinyl Aminopeptidase; Dietary Fats; Dietary Sucrose; Drug Administration Schedule; Glucose Intolerance; Hyperglycemia; Indomethacin; Insulin; Insulin Receptor Substrate Proteins; Janus Kinase 2; Losartan; Male; Mice; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases; Receptor, Angiotensin, Type 1; Signal Transduction | 2011 |
Regulation of angiotensin-(1-7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure.
Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Animals; Antibiotics, Antineoplastic; Benzimidazoles; Benzoates; Doxorubicin; Gene Expression Regulation; Heart; Heart Failure; Losartan; Male; Myocardium; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Telmisartan | 2011 |
Plasma and tissue concentrations of proangiotensin-12 in rats treated with inhibitors of the renin-angiotensin system.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Blood Pressure; Body Weight; Imidazolidines; Kidney; Losartan; Male; Myocardium; Organ Size; Peptide Fragments; Radioimmunoassay; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin; Renin-Angiotensin System | 2012 |
Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin-(1-7) or an angiotensin II receptor antagonist.
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme 2; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Intubation, Intratracheal; Lipopolysaccharides; Losartan; Lung; Macrophages, Alveolar; Male; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome | 2011 |
Angiotensin-(1-7)/Mas axis integrity is required for the expression of object recognition memory.
Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Hippocampus; Imidazoles; Losartan; Mice; Mice, Knockout; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pyridines; Receptors, Angiotensin; Receptors, G-Protein-Coupled; Recognition, Psychology | 2012 |
Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice.
Topics: 3T3-L1 Cells; Adipocytes; Adiposity; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Blood Pressure; Diet, High-Fat; Disease Models, Animal; Estrogens; Female; Gene Expression Regulation, Enzymologic; Hypertension; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity; Ovariectomy; Peptide Fragments; Peptidyl-Dipeptidase A; Progesterone; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptors, G-Protein-Coupled; Risk Factors; RNA, Messenger; Sex Factors; Testosterone; Time Factors; Weight Gain | 2012 |
Counteraction between angiotensin II and angiotensin-(1-7) via activating angiotensin type I and Mas receptor on rat renal mesangial cells.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blotting, Western; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Interactions; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Glomerular Mesangium; Imidazoles; Losartan; MAP Kinase Signaling System; Mesangial Cells; Microscopy, Confocal; Peptide Fragments; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pyridines; Rats; Real-Time Polymerase Chain Reaction; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Receptors, G-Protein-Coupled; Transforming Growth Factor beta1 | 2012 |
Characterization of Angiotensin-(1-7) effects on the cardiovascular system in an experimental model of type-1 diabetes.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Captopril; Cardiovascular System; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Endothelin-1; Hyperglycemia; Kidney; Losartan; Male; NADPH Oxidases; Peptide Fragments; Peptides; Peptidyl-Dipeptidase A; Prostaglandins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Reperfusion Injury | 2012 |
Angiotensin II and angiotensin-(1-7) in paraventricular nucleus modulate cardiac sympathetic afferent reflex in renovascular hypertensive rats.
Topics: Afferent Pathways; Angiotensin I; Angiotensin II; Animals; Blood Pressure; Body Weight; Heart; Heart Rate; Hypertension, Renovascular; Kidney; Losartan; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Reflex; Sympathetic Nervous System; Systole | 2012 |
The effects of para-chloromercuribenzoic acid and different oxidative and sulfhydryl agents on a novel, non-AT1, non-AT2 angiotensin binding site identified as neurolysin.
Topics: Angiotensin I; Angiotensin II; Angiotensins; Animals; Binding Sites; Losartan; Male; Metalloendopeptidases; Oxidation-Reduction; p-Chloromercuribenzoic Acid; Rats; Sulfhydryl Compounds | 2013 |
Antinociceptive response in transgenic mice expressing rat tonin.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Behavior, Animal; Disease Models, Animal; Losartan; Male; Mice; Mice, Transgenic; Nociception; Nociceptive Pain; Pain Measurement; Peptide Fragments; Rats; Receptors, G-Protein-Coupled; Tissue Kallikreins | 2013 |
Angiotensin II type 1 receptor blockade restores angiotensin-(1-7)-induced coronary vasodilation in hypertrophic rat hearts.
Topics: Angiotensin I; Animals; Cardiomegaly; Imidazoles; In Vitro Techniques; Losartan; Male; NG-Nitroarginine Methyl Ester; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pyridines; Rats; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Vasodilation | 2013 |
Mechanisms of the anti-inflammatory actions of the angiotensin type 1 receptor antagonist losartan in experimental models of arthritis.
Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Adhesion; Chemokine CXCL1; Disease Models, Animal; Female; Hyperalgesia; Inflammation; Interleukin-1beta; Leukocyte Rolling; Losartan; Male; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Tumor Necrosis Factor-alpha | 2013 |
Beneficial effects of the activation of the angiotensin-(1-7) MAS receptor in a murine model of adriamycin-induced nephropathy.
Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, Animal; Doxorubicin; Gene Expression Regulation; Humans; Imidazoles; Kidney Diseases; Kidney Glomerulus; Kidney Tubules; Losartan; Mice; Peptide Fragments; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; RNA, Messenger; Time Factors | 2013 |
Angiotensin-(1-7) attenuates lung fibrosis by way of Mas receptor in acute lung injury.
Topics: Acute Lung Injury; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, Animal; Lipopolysaccharides; Losartan; Male; Mice; Mice, Inbred C57BL; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pulmonary Fibrosis; Receptors, G-Protein-Coupled; Respiratory Distress Syndrome; Vasodilator Agents | 2013 |
Protective effects of angiotensin-(1-7) administrated with an angiotensin-receptor blocker in a rat model of chronic kidney disease.
Topics: Angiopoietins; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, Animal; Fibronectins; Losartan; Male; Nephrectomy; Peptide Fragments; Plasminogen Activator Inhibitor 1; Rats, Sprague-Dawley; Receptor, TIE-2; Renal Insufficiency, Chronic; Systole | 2013 |
Enhanced angiotensin-converting enzyme activity and systemic reactivity to angiotensin II in normotensive rats exposed to a high-sodium diet.
Topics: Aldosterone; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Pressure; Losartan; Male; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Sodium Chloride, Dietary | 2014 |
ACE2 activity was increased in atherosclerotic plaque by losartan: Possible relation to anti-atherosclerosis.
Topics: Angiotensin I; Angiotensin-Converting Enzyme 2; Animals; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Humans; Losartan; Male; Myocytes, Smooth Muscle; Peptide Fragments; Peptidyl-Dipeptidase A; Plaque, Atherosclerotic; Rabbits; Signal Transduction | 2015 |
Angiotensin-(1-7) modulates angiotensin II-induced vasoconstriction in human mammary artery.
Topics: Aged; Aged, 80 and over; Angiotensin I; Angiotensin II; Endothelium, Vascular; Female; Humans; Losartan; Male; Mammary Arteries; Middle Aged; Myocytes, Smooth Muscle; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Renin-Angiotensin System; Vasoconstriction | 2014 |
Comparison of angiotensin-(1-7), losartan and their combination on atherosclerotic plaque formation in apolipoprotein E knockout mice.
Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Abdominal; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Blood Pressure; Cell Line; Cell Movement; Cell Proliferation; Diet, High-Fat; Disease Models, Animal; Drug Therapy, Combination; Endothelium, Vascular; Humans; Lipids; Losartan; Macrophages; Male; Mice, Knockout; Muscle, Smooth, Vascular; Peptide Fragments; Plaque, Atherosclerotic; Renin-Angiotensin System; Superoxides; Time Factors; Vasodilation | 2015 |
Des-Aspartate-Angiotensin I Attenuates Mortality of Mice Exposed to Gamma Radiation via a Novel Mechanism of Action.
Topics: Angiotensin I; Angiotensin-Converting Enzyme Inhibitors; Animals; Dinoprostone; Female; Gamma Rays; Interleukin-6; Losartan; Mice; Mice, Inbred BALB C; Myelodysplastic Syndromes; Radiation-Protective Agents; Receptor, Angiotensin, Type 1; Tumor Necrosis Factor-alpha | 2015 |
Angiotensin-(1-7) enhances the effects of angiotensin II on the cardiac sympathetic afferent reflex and sympathetic activity in rostral ventrolateral medulla in renovascular hypertensive rats.
Topics: Analysis of Variance; Angiotensin I; Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; Drug Interactions; Hypertension, Renovascular; Losartan; Male; Medulla Oblongata; Peptide Fragments; Random Allocation; Rats; Rats, Sprague-Dawley; Reflex; Sympathetic Nervous System; Treatment Outcome | 2015 |
Angiotensin-(1-7)/Mas axis modulates fear memory and extinction in mice.
Topics: Acoustic Stimulation; Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Animals; Avoidance Learning; Conditioning, Classical; Electroshock; Extinction, Psychological; Fear; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled | 2016 |
The renin-angiotensin system and its vasoactive metabolite angiotensin-(1-7) in the mechanism of the healing of preexisting gastric ulcers. The involvement of Mas receptors, nitric oxide, prostaglandins and proinflammatory cytokines.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Cytokines; Enzyme Inhibitors; Gastric Mucosa; Imidazoles; Indomethacin; Interleukin-1beta; Lisinopril; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Prostaglandins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Renin-Angiotensin System; Stomach Ulcer; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2016 |
Angiotensin-(1-7)/Mas receptor as an antinociceptive agent in cancer-induced bone pain.
Topics: Analgesics; Analysis of Variance; Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Bone Neoplasms; Cancer Pain; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Imidazoles; Losartan; Mice; Mice, Inbred BALB C; Nesting Behavior; Peptide Fragments; Pyridines; Rotarod Performance Test | 2016 |
Influence of antihypertensive drugs on aortic and coronary effects of Ang-(1-7) in pressure-overloaded rats.
Topics: Amlodipine; Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aorta, Abdominal; Blood Pressure; Calcium Channel Blockers; Captopril; Coronary Vessels; Losartan; Male; Mineralocorticoid Receptor Antagonists; Models, Animal; Peptide Fragments; Rats, Wistar; Reproducibility of Results; Spironolactone; Time Factors; Vasoconstriction; Vasodilation | 2017 |
The ACE-2/Ang1-7/Mas cascade enhances bone structure and metabolism following angiotensin-II type 1 receptor blockade.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Female; Femur; Losartan; Minerals; Peptide Fragments; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Renin-Angiotensin System | 2017 |
Intrarenal Mas and AT
Topics: Anesthesia, General; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Diet, Sodium-Restricted; Glomerular Filtration Rate; Hemodynamics; Infusions, Parenteral; Kidney; Losartan; Male; Natriuresis; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Renal Circulation; Renal Elimination; Renin-Angiotensin System; Signal Transduction; Sodium, Dietary | 2017 |
Direct renin inhibition is not enough to prevent reactive oxygen species generation and vascular dysfunction in renovascular hypertension.
Topics: Amides; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta; Drug Synergism; Fumarates; Hypertension, Renovascular; Losartan; Male; Nitrites; Oxidative Stress; Rats; Reactive Oxygen Species; Relaxation; Renin | 2018 |
Severe food restriction activates the central renin angiotensin system.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Arterial Pressure; Autoradiography; Caloric Restriction; Female; Heart Rate; Hypothalamus; Injections, Intraventricular; Losartan; Organum Vasculosum; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Peptidyl-Dipeptidase A; Preoptic Area; Rats; Rats, Inbred F344; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Starvation; Subfornical Organ | 2020 |
N-Acetyl-Seryl-Asparyl-Lysyl-Proline regulates lung renin angiotensin system to inhibit epithelial-mesenchymal transition in silicotic mice.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cell Line; Epithelial-Mesenchymal Transition; Fibrosis; Losartan; Lung; Male; Mice, Inbred C57BL; Oligopeptides; Peptide Fragments; Peptidyl-Dipeptidase A; Renin-Angiotensin System; Silicosis | 2020 |
Angiotensinergic receptors in the medial amygdaloid nucleus differently modulate behavioral responses in the elevated plus-maze and forced swimming test in rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Behavior, Animal; Corticomedial Nuclear Complex; Imidazoles; Losartan; Male; Maze Learning; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Swimming | 2021 |
Local Renin-Angiotensin System Signaling Mediates Cellular Function of Aortic Valves.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aortic Valve; Cells, Cultured; Fluorescent Antibody Technique; Losartan; Myofibroblasts; Peptidyl-Dipeptidase A; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Swine; Tetrahydroisoquinolines | 2021 |
Angiotensin Type 2 and Mas Receptor Activation Prevents Myocardial Fibrosis and Hypertrophy through the Reduction of Inflammatory Cell Infiltration and Local Sympathetic Activity in Angiotensin II-Dependent Hypertension.
Topics: Angiotensin I; Angiotensin II; Animals; Cardiomegaly; Disease Models, Animal; Fibrosis; Hypertension; Imidazoles; Injections, Intraperitoneal; Losartan; Male; Peptide Fragments; Proto-Oncogene Mas; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiophenes; Tyrosine 3-Monooxygenase | 2021 |