losartan and amiloride

losartan has been researched along with amiloride in 27 studies

Research

Studies (27)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (18.52)	18.2507
2000's	9 (33.33)	29.6817
2010's	12 (44.44)	24.3611
2020's	1 (3.70)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Avdeef, A; Tam, KY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Barreto-Chaves, ML; Mello-Aires, M	1
Alvarez, BV; Camilión de Hurtado, MC; Cingolani, HE; Ennis, IL; Pérez, NG	1
Alvarez, BV; Camilión de Hurtado, MC; Cingolani, HE; Ennis, IL	1
Han, HJ; Koh, HJ; Park, SH	1
Leenen, FH; Ruzicka, M; Yuan, B	1
Nagami, GT	1
Bell, PD; Peti-Peterdi, J; Warnock, DG	1
Gick, G; Isenovic, ER; Jacobs, DB; Kawakami, K; Kedees, MH; Milivojevic, N; Sha, Q; Sowers, JR	1
Mello-Aires, M; Musa-Aziz, R; Oliveira-Souza, M	1
Castro-Chaves, P; Ferreira-Martins, J; Guerra, MS; Leite-Moreira, AF; Lima-Carneiro, A; Pimentel-Nunes, P; Soares, JB	1
Ashby, MJ; Brown, MJ; Hood, SJ; Taylor, KP	1
Milan, A; Mulatero, P; Veglio, F	1
Freel, RW; Hatch, M	1
Gabor, A; Leenen, FH	1
Carretero, OA; D'Ambrosio, MA; Garvin, JL; Ren, Y	1
Afiune Neto, A; Alves, JG; Berwanger, O; Bortolotto, L; Brandão, AA; Castro, I; Cesarino, EJ; Chaves, H; Coelho, EB; Consolim-Colombo, F; de Mello, RB; de Sousa, MR; Figueiredo Neto, JA; Franco, R; Fuchs, FD; Fuchs, SC; Ghizzoni, F; Gus, M; Irigoyen, MC; Jardim, PC; Mion, D; Moreira, LB; Moreno, H; Mosele, F; Mota, M; Nobre, F; Nóbrega, AC; Pereira e Silva, R; Poli-de-Figueiredo, CE; Ribeiro, AL; Scala, LC; Schlatter, R; Sobral Filho, DC; Steffens, AA; Vilela-Martin, JF	1
Chen, S; Cui, Y; Jiang, J; Peng, J; Shen, J; Wang, W; Wu, Q	1
Danser, AH; Fenton, RA; Hoorn, EJ; Lim, CH; Meima, ME; Mutig, K; Rosenbaek, LL; van der Lubbe, N; van Veghel, R; Zietse, R	1
Brines, L; Calvo, C; Canto, ID; Chorro, FJ; Soler, C; Such, L; Such-Miquel, L; Tormos, Á; Trapero, I; Zarzoso, M	1
Alves, JG; Berwanger, O; Bortolotto, LA; Brandão, AA; Castro, I; Cesarino, EJ; Chaves, H; de Alencastro, PR; de Mello, RB; de Sousa, MR; E Silva, RP; Filho, DC; Franco, RS; Fuchs, FC; Fuchs, FD; Fuchs, SC; Gomes, MM; Gus, M; Jardim, PC; Moreira, LB; Mosele, F; Neto, AA; Neto, JA; Nobre, F; Nóbrega, AC; Poli-de-Figueiredo, CE; Scala, LC; Schlatter, R; Steffens, AA; Vilela-Martin, JF; Whelton, PK	1
Bertoluci, C; Branchi, TV; Foppa, M; Fuchs, FD; Fuchs, SC; Santos, ABS	1
Bertoluci, C; Foppa, M; Fuchs, FD; Fuchs, SC; Santos, ABS	1
Afiune Neto, A; Alves, JG; Berwanger, O; Bortolotto, LA; Brandão, AA; Castro, I; Cesarino, JE; Chaves, H; Consolim-Colombo, FM; de Sousa, MR; Figueiredo Neto, JA; Franco, RS; Fuchs, FC; Fuchs, FD; Fuchs, SC; Gomes, MM; Gus, M; Jardim, PC; Moreira, LB; Nobre, F; Nóbrega, AC; Pereira E Silva, R; Poli-de-Figueiredo, CE; Scala, LCN; Schlatter, RP; Sobral Filho, DC; Steffens, AA; Vilela-Martin, JF; Whelton, PK	1

Reviews

1 review(s) available for losartan and amiloride

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

6 trial(s) available for losartan and amiloride

Article	Year
The spironolactone, amiloride, losartan, and thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio. Circulation, 2007, Jul-17, Volume: 116, Issue:3 Topics: Aged; Aldosterone; Amiloride; Bendroflumethiazide; Cross-Over Studies; Double-Blind Method; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Renin; Single-Blind Method; Sodium Chloride Symporter Inhibitors; Spironolactone	2007
A comparison between diuretics and angiotensin-receptor blocker agents in patients with stage I hypertension (PREVER-treatment trial): study protocol for a randomized double-blind controlled trial. Trials, 2011, Feb-24, Volume: 12 Topics: Adult; Aged; Amiloride; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Brazil; Chlorthalidone; Diuretics; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Research Design; Severity of Illness Index; Time Factors; Treatment Outcome	2011
Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension: results from the PREVER-treatment randomized trial. Journal of hypertension, 2016, Volume: 34, Issue:4 Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Humans; Hypertension; Losartan; Middle Aged	2016
Echocardiographic Left Ventricular Reverse Remodeling After 18 Months of Antihypertensive Treatment in Stage I Hypertension. Results From the Prever-Treatment Study. American journal of hypertension, 2018, 02-09, Volume: 31, Issue:3 Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Atrial Function, Left; Atrial Remodeling; Blood Pressure; Chlorthalidone; Double-Blind Method; Echocardiography, Doppler; Female; Heart Ventricles; Humans; Hypertension; Losartan; Male; Middle Aged; Predictive Value of Tests; Time Factors; Treatment Outcome; Ventricular Function, Left; Ventricular Remodeling	2018
Diuretics are Similar to Losartan on Echocardiographic Target-Organ Damage in Stage I Hypertension. PREVER-Treatment Study. Arquivos brasileiros de cardiologia, 2019, Volume: 112, Issue:1 Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Blood Pressure; Diuretics; Double-Blind Method; Echocardiography; Female; Follow-Up Studies; Humans; Hypertension; Losartan; Male; Middle Aged; Time Factors; Treatment Outcome; Ventricular Remodeling	2019
Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trial. Acta diabetologica, 2021, Volume: 58, Issue:2 Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Blood Pressure; Brazil; Chlorthalidone; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Severity of Illness Index; Treatment Outcome	2021

Other Studies

20 other study(ies) available for losartan and amiloride

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Effect of luminal angiotensin II and ANP on early and late cortical distal tubule HCO3- reabsorption. The American journal of physiology, 1996, Volume: 271, Issue:5 Pt 2 Topics: Absorption; Amiloride; Angiotensin II; Animals; Anti-Bacterial Agents; Atrial Natriuretic Factor; Bicarbonates; Biphenyl Compounds; Enzyme Inhibitors; Imidazoles; Kidney Cortex; Kidney Tubules, Distal; Losartan; Macrolides; Male; Rats; Rats, Wistar; Tetrazoles	1996
Angiotensin II activates Na+-independent Cl--HCO3- exchange in ventricular myocardium. Circulation research, 1998, Mar-09, Volume: 82, Issue:4 Topics: Alkaloids; Amiloride; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antiporters; Benzophenanthridines; Bicarbonates; Cats; Chloride-Bicarbonate Antiporters; Chlorides; Enzyme Inhibitors; Heart Ventricles; Hydrogen-Ion Concentration; In Vitro Techniques; Losartan; Myocardium; Phenanthridines; Protein Kinase C; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Signal Transduction; Sodium; Sodium-Hydrogen Exchangers	1998
Stretch-induced alkalinization of feline papillary muscle: an autocrine-paracrine system. Circulation research, 1998, Oct-19, Volume: 83, Issue:8 Topics: Alkalies; Alkaloids; Amiloride; Angiotensin II; Animals; Anti-Arrhythmia Agents; Autocrine Communication; Benzophenanthridines; Cats; Endothelin Receptor Antagonists; Endothelins; Enzyme Inhibitors; Heart; Hydrogen-Ion Concentration; Losartan; Muscle Contraction; Muscle Fibers, Skeletal; Oligopeptides; Papillary Muscles; Paracrine Communication; Peptides, Cyclic; Phenanthridines; Protein Kinase C; Sodium-Hydrogen Exchangers	1998
A signaling pathway for stimulation of Na+ uptake induced by angiotensin II in primary cultured rabbit renal proximal tubule cells. The Journal of veterinary medical science, 1999, Volume: 61, Issue:2 Topics: Amiloride; Angiotensin II; Animals; Antihypertensive Agents; Cells, Cultured; Cyclic AMP; Diuretics; Imidazoles; Kidney Tubules, Proximal; Losartan; Male; Protein Kinase C; Pyridines; Rabbits; Receptors, Angiotensin; Signal Transduction; Sodium; Staurosporine; Tetradecanoylphorbol Acetate	1999
Blockade of AT(1) receptors and Na(+)/H(+) exchanger and LV dysfunction after myocardial infarction in rats. The American journal of physiology, 1999, Volume: 277, Issue:2 Topics: Amiloride; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Blood Volume; Drug Combinations; Hemodynamics; Hyperemia; Hypertension; Losartan; Male; Myocardial Infarction; Myocardium; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sodium-Hydrogen Exchangers; Ventricular Dysfunction, Left	1999
Enhanced ammonia secretion by proximal tubules from mice receiving NH(4)Cl: role of angiotensin II. American journal of physiology. Renal physiology, 2002, Volume: 282, Issue:3 Topics: Acid-Base Equilibrium; Acids; Amiloride; Ammonia; Ammonium Chloride; Angiotensin II; Animals; Antihypertensive Agents; Carbon Dioxide; Diuretics; Kidney Tubules, Proximal; Losartan; Male; Mice; Microcirculation; Potassium; Renal Circulation; Vasoconstrictor Agents	2002
Angiotensin II directly stimulates ENaC activity in the cortical collecting duct via AT(1) receptors. Journal of the American Society of Nephrology : JASN, 2002, Volume: 13, Issue:5 Topics: Amiloride; Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Benzofurans; Biphenyl Compounds; Hydrogen-Ion Concentration; Intracellular Membranes; Ionophores; Kidney Tubules, Collecting; Losartan; Mice; Microscopy, Fluorescence; Monensin; Rabbits; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Signal Transduction; Sodium Chloride; Tetrazoles	2002
Angiotensin II regulation of the Na+ pump involves the phosphatidylinositol-3 kinase and p42/44 mitogen-activated protein kinase signaling pathways in vascular smooth muscle cells. Endocrinology, 2004, Volume: 145, Issue:3 Topics: Amiloride; Angiotensin II; Animals; Antihypertensive Agents; Aorta, Thoracic; Biological Transport; Cells, Cultured; Diuretics; Losartan; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Sodium-Potassium-Exchanging ATPase; Transcription, Genetic; Vasoconstrictor Agents	2004
Signaling pathways in the biphasic effect of ANG II on Na+/H+ exchanger in T84 cells. The Journal of membrane biology, 2005, Volume: 205, Issue:2 Topics: Amiloride; Angiotensin II; Calcium; Cell Line, Tumor; Cell Size; Colon; Colonic Neoplasms; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Hydrogen-Ion Concentration; Isoquinolines; Losartan; Signal Transduction; Sodium-Hydrogen Exchangers; Staurosporine; Sulfonamides	2005
Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect. British journal of pharmacology, 2006, Volume: 147, Issue:6 Topics: Alkaloids; Amiloride; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzophenanthridines; Diastole; Dose-Response Relationship, Drug; Elasticity; Heart; Losartan; Male; Myocardial Contraction; Myocardium; Naphthyridines; Phenanthridines; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Receptor, Angiotensin, Type 1; Sodium-Hydrogen Exchangers; Ventricular Function, Left	2006
Letter regarding article by Hood et al, "The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio". Circulation, 2008, Feb-05, Volume: 117, Issue:5 Topics: Aldosterone; Amiloride; Antihypertensive Agents; Bendroflumethiazide; Cross-Over Studies; Double-Blind Method; Humans; Hypertension; Losartan; Sodium Chloride Symporter Inhibitors; Spironolactone	2008
Increased colonic sodium absorption in rats with chronic renal failure is partially mediated by AT1 receptor agonism. American journal of physiology. Gastrointestinal and liver physiology, 2008, Volume: 295, Issue:2 Topics: Amiloride; Angiotensin II; Animals; Colon; Epithelial Sodium Channels; Intestinal Absorption; Kidney Failure, Chronic; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Sodium; Sodium-Hydrogen Exchangers; Water-Electrolyte Balance	2008
Mechanisms in the PVN mediating local and central sodium-induced hypertension in Wistar rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 296, Issue:3 Topics: Aldosterone; Amiloride; Angiotensins; Animals; Antihypertensive Agents; Blood Pressure; Cardiotonic Agents; Cerebrospinal Fluid; Diuretics; Dose-Response Relationship, Drug; Eplerenone; Heart Rate; Hypertension; Injections, Intraventricular; Losartan; Ouabain; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; Sodium; Spironolactone	2009
Angiotensin II enhances connecting tubule glomerular feedback. Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:4 Topics: Amiloride; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Arterioles; Dose-Response Relationship, Drug; Epithelial Sodium Channel Blockers; Epithelial Sodium Channels; Feedback, Physiological; Glomerular Filtration Rate; Imidazoles; Kidney Glomerulus; Kidney Tubules; Losartan; Microcirculation; Pyridines; Rabbits; Receptor, Angiotensin, Type 2; Sodium Channel Blockers; Sodium Chloride; Vasoconstrictor Agents; Vasodilation	2010
Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice. Kidney international, 2012, Volume: 82, Issue:1 Topics: Aldosterone; Amiloride; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Body Weight; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationship, Drug; Homeostasis; Hypertension; Kidney; Losartan; Male; Mice; Mice, Knockout; Natriuresis; Renin; Serine Endopeptidases; Sodium Channel Blockers; Sodium Chloride, Dietary; Telemetry; Time Factors	2012
Aldosterone does not require angiotensin II to activate NCC through a WNK4-SPAK-dependent pathway. Pflugers Archiv : European journal of physiology, 2012, Volume: 463, Issue:6 Topics: Adrenalectomy; Aldosterone; Amiloride; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Diuretics; Dose-Response Relationship, Drug; Hydrochlorothiazide; Kidney; Losartan; Models, Animal; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium Chloride Symporters	2012
Experimental Study of the Effects of EIPA, Losartan, and BQ-123 on Electrophysiological Changes Induced by Myocardial Stretch. Revista espanola de cardiologia (English ed.), 2015, Volume: 68, Issue:12 Topics: Amiloride; Angiotensin II Type 1 Receptor Blockers; Animals; Endothelin Receptor Antagonists; Epithelial Sodium Channel Blockers; Heart; Losartan; Myocardium; Peptides, Cyclic; Rabbits; Sodium-Hydrogen Exchangers; Stress, Physiological; Ventricular Fibrillation	2015