losartan has been researched along with aldosterone in 165 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 59 (35.76) | 18.2507 |
| 2000's | 70 (42.42) | 29.6817 |
| 2010's | 35 (21.21) | 24.3611 |
| 2020's | 1 (0.61) | 2.80 |
| Authors | Studies |
|---|---|
| Strassburg, CP; Tukey, RH | 1 |
| Balla, T; Csordás, G; Enyedi, P; Hajnóczky, G; Hunyady, L; Kalapos, MP; Spät, A | 1 |
| Franco-Saenz, R; Mulrow, PJ; Yamaguchi, T | 1 |
| Aguilera, G | 1 |
| Biollaz, J; Borland, RM; Brunner, HR; Christen, Y; Lee, RJ; Munafo, A; Nussberger, J; Shum, LY; Waeber, B | 1 |
| Blaine, EH; Blehm, DJ; Corpus, VM; Huang, HC; Manning, RE; McMahon, EG; Olins, GM; Palomo, MA; Reitz, DB; Schuh, JR | 1 |
| Chakravarty, PK; Chang, RS; Clineschmidt, BV; Greenlee, WJ; Lotti, VJ; Mantlo, NB; Patchett, AA; Siegl, PK | 1 |
| Chakravarty, PK; Chang, RS; Greenlee, WJ; Lotti, VJ; Mantlo, NB; Ondeyka, DL; Patchett, AA; Siegl, PK; Sweet, CS | 1 |
| Bunting, PB; Cartwright, ME; Frank, JD; Gibson, RE; Schorn, TW; Siegl, PK; Thorpe, HH | 1 |
| Balla, T; Baukal, AJ; Catt, KJ; Eng, S | 1 |
| Jackson, EK; Pong, AS; Tofovic, SP | 1 |
| Ardecky, RJ; Chiu, AT; Hart, SD; Smith, RD; Timmermans, PB; Wong, PC; Zaspel, AM | 1 |
| Chang, RS; Lotti, VJ | 1 |
| Ashton, WT; Chang, LL; Flanagan, K; Gabel, RA; Greenlee, WJ; Kivlighn, SD; Schaffer, LW; Schorn, TW; Siegl, PK; Zingaro, GJ | 1 |
| Bauer, IH; Lau-Sieckman, A; Reams, GP; Wu, Z | 1 |
| Doig, JK; MacFadyen, RJ; Reid, JL; Sweet, CS | 1 |
| Doig, JK; Lees, KR; MacFadyen, RJ; Reid, JL; Sweet, CS | 1 |
| Funder, JW; Provencher, PH; Saltis, J | 1 |
| Carroll, J; Grossman, E; Peleg, E; Rosenthal, T; Shamiss, A | 1 |
| Broten, TP; Chakravarty, PK; Gabel, RA; Greenlee, WJ; Kivlighn, SD; Naylor, EM; Patchett, AA; Schaffer, LW; Schorn, TW; Zingaro, GJ | 1 |
| Enea, I; Ganten, D; Gigante, B; Lee, MA; Porcellini, A; Romano, M; Rubattu, S; Russo, R; Trimarco, B; Volpe, M | 1 |
| Lienard, F; Martial, FP; Mousseau, MC; Nicolaidis, S; Thornton, SN | 2 |
| Boulay, G; Chrétien, L; Guillemette, G; Richard, DE | 1 |
| Dupont, M; Jover, B; Mimran, A; Nafrialdi, N; Saladini, D | 1 |
| Chiou, CY; Kifor, I; Moore, TJ; Williams, GH | 1 |
| Brunner, HR; Burnier, M; Nussberger, J; Rutschmann, B; Shahinfar, S; Versaggi, J; Waeber, B | 1 |
| Cook, MD; Cook, VI; Kimura, B; Phillips, MI; Wilcox, CS | 1 |
| Lever, AF; MacFadyen, RJ; Reid, JL; Tree, M | 1 |
| Couch, SJ; DeGraaf, GL; Lawson, JA; Pals, DT | 1 |
| Nakashima, M; Ohtawa, M; Saitoh, K; Takayama, F; Yoshinaga, T | 1 |
| Ebihara, A; Fujimura, A; Harada, K; Sasaki, M; Sunaga, K | 1 |
| Greene, EL; Hostetter, TH; Kren, S | 1 |
| Inagami, T; Landon, EJ; Naruse, M; Piston, DW; Tamura, M; Tani, M | 1 |
| Hannedouche, TP; Lacour, B; Martinez, F; Natov, S; Schmitt, F | 1 |
| Galaverna, O; Liénard, F; Martial, FP; Meile, MJ; Mousseau, MC; Nicolaïdis, S; Thornton, SN | 1 |
| Funder, JW; Young, MJ | 1 |
| Brown, NJ; Gandhi, SK; Ryder, DH | 1 |
| Barrows, S; Dunn, MJ; Meibohm, A; Shahinfar, S; Simpson, RL; Smith, MC; Weigel, K | 1 |
| Azizi, M; Chatellier, G; Guyene, TT; Ménard, J; Wargon, M | 1 |
| Cargill, RI; Coutie, WJ; Kiely, DG; Lipworth, BJ; Wheeldon, NM | 1 |
| Lotshaw, DP | 1 |
| Dige-Petersen, H; Frandsen, E; Ibsen, H; Worck, RH | 1 |
| Annoura, M; Arakawa, K; Handa, K; Hiroki, T; Kumagai, K; Matsuo, K; Nakashima, Y; Yamanouchi, Y | 1 |
| Chong, CK; Honrath, U; Sonnenberg, H; Veress, AT | 1 |
| Ball, DL; Elliott, ME; Goodfriend, TL; Jefcoate, CR | 1 |
| Dumont, CJ; Grekin, RJ; Vollmer, AP; Watts, SW; Webb, RC | 1 |
| De Paolis, P; Enea, I; Gigante, B; Natale, A; Piras, O; Porcellini, A; Rubattu, S; Russo, R; Savoia, C; Volpe, M | 1 |
| Freel, RW; Hatch, M; Vaziri, ND | 1 |
| Galaverna, O; Liénard, F; Meile, MJ; Nicolaïdis, S; Thornton, SN | 1 |
| Andreis, PG; Belloni, AS; Gottardo, G; Macchi, V; Malendowicz, LK; Nussdorfer, GG | 1 |
| Gottardo, G; Macchi, V; Malendowicz, LK; Mazzocchi, G; Nussdorfer, GG | 1 |
| Gray, GA; Kenyon, CJ; McEwan, PE; Sherry, L; Webb, DJ | 2 |
| Gretz, N; Kränzlin, B; Maser-Gluth, C; Obermüller, N; Peters, B; Peters, J; Woyth, A | 1 |
| Bornstein, SR; Correa, FM; Ehrhart-Bornstein, M; Hilbers, U; Jöhren, O; Peters, J; Saavedra, JM | 1 |
| Capponi, AM; Casal, AJ; Demaurex, N; Maturana, AD; Rossier, MF; Vallotton, MB | 1 |
| Agirbasli, M; Brown, NJ; Vaughan, DE | 1 |
| Miller, JA; Scholey, JW; Thai, K | 1 |
| Kojima, S; Kuramochi, M; Saotome, M; Shida, M; Tanaka, K; Yoshitomi, Y | 1 |
| Bischoff, A; Michel, MC | 1 |
| Puddefoot, JR; Vinson, GP; Xiao, F | 1 |
| Albertin, G; Malendowicz, LK; Markowska, A; Mazzocchi, G; Nussdorfer, GG | 1 |
| Gehr, TW; Halstenson, CE; Keane, WF; Sica, DA | 1 |
| Grossman, E; Messerli, FH; Neutel, JM | 1 |
| Meyer, TW; Olson, JL; Sorooshian, M | 1 |
| Henger, A; Hulter, HN; Krapf, R; Riesen, WF; Tutt, P | 1 |
| Cattran, DC; Duncan, JA; Floras, JS; Kang, AK; Lai, V; Miller, JA; Scholey, JW | 1 |
| Vinson, GP; Whitworth, E | 1 |
| Agarwal, R | 1 |
| Miller, AB; Srivastava, P | 1 |
| Andreucci, M; Balletta, MM; Esposito, R; Minutolo, R; Pisani, A; Russo, D; Signoriello, G | 1 |
| Atanassova, I; Natchev, E; Orbetzova, M; Tzingilev, D; Zacharieva, S | 1 |
| Inami, S; Kojima, S; Kuramochi, M; Shida, M; Takano, H; Yodogawa, K; Yokoyama, H | 1 |
| Homma, T; Ichikawa, I; Katori, H; Matsusaka, T; Miyazaki, Y; Takaya, J; Tamura, M | 1 |
| Guo, Z; Lai, W; Li, J; Li, S; Liang, X; Liu, Y; Wu, P; Xiu, J; Zhang, Y; Zhong, S | 1 |
| Demura, M; Mabuchi, H; Takeda, Y; Usukura, M; Yoneda, T | 1 |
| Campbell, DJ; Mackie, FE; Meyer, TW | 1 |
| Bonaduce, D; Condorelli, M; De Santis, V; Petretta, M; Schiavone, D; Spinelli, L; Vicario, ML | 1 |
| Hayasaki-Kajiwara, Y; Iwasaki, T; Nakajima, M; Naya, N; Shimamura, T | 1 |
| Duggan, KA; Hodge, G; Ye, VZ | 1 |
| Allen, TJ; Baxter, AL; Casley, DJ; Cooper, ME; Houlihan, CA; Jerums, G; Panangiotopoulos, S | 1 |
| Blendis, L; Liu, P; Wong, F | 1 |
| Guo, Z; Lai, W; Li, J; Li, S; Liu, Y; Wu, P; Xiu, JC; Xu, JP; Zhang, Y | 1 |
| Djurhuus, JC; Frøkiaer, J; Hvistendahl, JJ; Pedersen, EB; Pedersen, TS | 1 |
| Funder, JW; Mardini, M; Mihailidou, AS; Raison, M | 1 |
| Andersson, OK; Elmfeldt, D; Friberg, PR; Fridman, KU; Wysocki, M | 1 |
| Weber, MA | 1 |
| Fukuda, N; Onose, Y; Sakabe, K; Shinohara, H; Soeki, T; Tamura, Y | 1 |
| Kong, J; Li, YC | 1 |
| Burnett, JC; Cataliotti, A; Chen, HH; Nordstrom, LJ; Redfield, MM | 1 |
| Flack, JM; Garthwaite, S; Kleiman, JH; Krause, SL; Oparil, S; Pratt, JH; Roniker, B; Saunders, E; Workman, D; Yang, Y | 1 |
| Ben-Yehuda, O | 1 |
| Abukhalaf, IK; Bayorh, MA; Eatman, D; Ganafa, AA; Silvestrov, N; Socci, RR | 1 |
| Kawecka-Jaszcz, K; Klocek, M; Rajzer, M | 1 |
| DeVita, MV; Lavie, RH; Michelis, MF; Panos, J; Wilkes, BM | 1 |
| Boomsma, F; Lameris, TW; van de Ven, LL; van den Meiracker, AH | 1 |
| Anzai, T; Hashimoto, K; Himeno, H; Imai, K; Kawana, M; Kitakaze, M; Koretsune, Y; Maruyama, S; Masaoka, Y; Matsubara, H; Matsuoka, T; Miyao, Y; Miyatake, K; Miyauchi, T; Nakamura, Y; Nomura, F; Okamoto, H; Ozono, K; Sekiya, M; Shinohara, H; Shintani, U; Shiraki, T; Takaoka, H; Tsutamoto, T; Yasumura, Y; Yokoya, K; Yokoyama, H | 1 |
| Aviram, M; Coleman, R; Hamoud, S; Hayek, T; Kaplan, M; Keidar, S; Pavlotzky, E | 1 |
| Amiri, F; Iglarz, M; Schiffrin, EL; Touyz, RM; Viel, EC | 1 |
| Bäcklund, T; Eriksson, A; Finckenberg, P; Gröholm, T; Laine, M; Mervaala, E; Palojoki, E; Saraste, A; Tikkanen, I | 1 |
| Andersen, S; Parving, HH; Rossing, P; Schjoedt, KJ; Tarnow, L | 1 |
| Bos, R; Findji, L; Lechat, P; Médiani, O; Mougenot, N; Vanhoutte, PM | 1 |
| Jaffe, IZ; Mendelsohn, ME | 1 |
| Ito, Y; Mabuchi, H; Oda, N; Takeda, Y; Usukura, M; Yoneda, T | 1 |
| Al-Saadi, N; Dechend, R; Fiebeler, A; Hilfenhaus, G; Jeng, AY; Luft, FC; Maser-Gluth, C; Meiners, S; Muller, DN; Nussberger, J; Rong, S; Shagdarsuren, E; Webb, RL; Wellner, M | 1 |
| Arrizurieta, E; Barontini, M; Carranza, A; De Luca Sarobe, V; Ibarra, FR; Levin, G; Nowicki, S | 1 |
| Bayorh, MA; Eatman, D; Feuerstein, GZ; Ganafa, AA; Walton, M | 1 |
| Beauséjour, A; Brochu, M; Sicotte, B; St-Louis, J | 1 |
| Sica, DA | 1 |
| Hirata, A; Igarashi, M; Kadomoto, Y; Tominaga, M | 1 |
| Hayashi, A; Kimoto, K; Murakami, M; Murakami, T; Otani, L; Yasumatsu, T | 1 |
| Furusu, A; Horita, Y; Kohno, S; Taguchi, T; Taura, K | 1 |
| Ashby, MJ; Brown, MJ; Hood, SJ; Taylor, KP | 1 |
| Bayorh, MA; Eatman, D; Feuerstein, GZ; Layas, MF; Mann, G | 1 |
| Carstens, J; Pedersen, EB | 1 |
| Li, XC; Zhuo, JL | 1 |
| Baek, A; Cho, H; Han, SH; Jeon, JH; Kim, D; Kim, E; Kim, JH; Kim, JW; Kim, KI; Kim, KY; Kim, SH; Lee, YH; Lim, JS; Oh, GT; Yang, Y; Yoon, DY | 1 |
| Milan, A; Mulatero, P; Veglio, F | 1 |
| Boomsma, F; de Zeeuw, D; Navis, G; Vogt, L; Waanders, F | 1 |
| Chen, YM; Chiang, WC; Lin, SL; Tsai, TJ; Wu, KD | 1 |
| Brunner, HR; Burnier, M; Waeber, B | 1 |
| Celiński, K; Czechowska, G; Korobowicz, E; Korolczuk, A; Madro, A; Prozorow-Król, B; Słomka, M | 1 |
| Gabor, A; Leenen, FH | 1 |
| Bai, SC; Deng, LH; Huang, P; Su, L; Wen, YW; Wu, ZL; Xu, DL | 1 |
| Lim, BH; Park, JB; Park, YM; Touyz, RM | 1 |
| Bürgelová, M; Cervenka, L; Erbanová, M; Husková, Z; Kramer, HJ; Mullins, JJ; Rakusan, D; Thumová, M; Vanecková, I; Vanourková, Z | 1 |
| Antikainen, M; Donner, KM; Hannila-Handelberg, T; Hiltunen, TP; Hirvonen, A; Kontula, K; Suonsyrjä, T; Tikkanen, I | 1 |
| Ichihara, A; Itoh, H; Kinouchi, K; Kurauchi-Mito, A; Sakoda, M | 1 |
| Casarini, DE; Coelho, MS; Ferreira, DN; Furukawa, LN; Heimann, JC; Katayama, IA; Oliveira, IB; Rosa, KT | 1 |
| Cervenka, L; Chábová, VČ; Husková, Z; Kompanowska-Jezierska, E; Kopkan, L; Kramer, HJ; Kujal, P; Malý, J; Netuka, I; Opočenský, M; Rakušan, D; Sadowski, J; Schejbalová, S; Skaroupková, P; Vaněčková, I; Vaňourková, Z; Vernerová, Z; Walkowska, A | 1 |
| Goda, A; Hirotani, S; Lee-Kawabata, M; Masuyama, T; Matsumoto, M; Naito, Y; Nakaboh, A; Ohyanagi, M; Otsuka, M; Tsujino, T; Yoshida, C | 1 |
| Kim, J; Koch, WJ; Lymperopoulos, A; Rengo, G; Zincarelli, C | 1 |
| Appelbaum, E; Dahlöf, B; Desai, A; Lukashevich, V; Pouleur, AC; Prescott, MF; Smith, BA; Solomon, SD; Uno, H | 1 |
| Felder, RB; Wei, SG; Yu, Y; Zhang, ZH | 1 |
| Appelbaum, E; Dahlof, B; Pouleur, AC; Prescott, M; Smith, B; Solomon, SD; Takeuchi, M; Vardeny, O; Verma, A | 1 |
| Chen, S; Cui, Y; Jiang, J; Peng, J; Shen, J; Wang, W; Wu, Q | 1 |
| Danser, AH; Fenton, RA; Hoorn, EJ; Lim, CH; Meima, ME; Mutig, K; Rosenbaek, LL; van der Lubbe, N; van Veghel, R; Zietse, R | 1 |
| Adem, A; Ali, MA; Benedict, S; Chandranath, IS; Frampton, CM; Kazzam, E; Lewis, LK; Nagelkerke, N; Nicholls, GM; Nyberg, F; Pathan, JY; Yandle, TG | 1 |
| Lin, J; Lin, L; Peng, F; Tang, H | 1 |
| Coletta, E; Davies, R; Floras, JS; Haddad, H; Leenen, FH; McReynolds, AJ; Ruzicka, M | 1 |
| Campbell, WB; Gomez-Sanchez, CE; Gomez-Sanchez, EP; Kopf, PG; Luis Lam, M; Oki, K; Yamazaki, T | 1 |
| Arnold, AC; Biaggioni, I; Gamboa, A; Okamoto, LE; Raj, SR; Robertson, D; Shibao, C | 1 |
| Arias, SC; Camara, NO; de Brito, T; Fanelli, C; Fujihara, CK; Machado, FG; Malheiros, DM; Origassa, CS; Valente, CP; Zatz, R | 1 |
| Cassis, LA; Daugherty, A; Gong, MC; Guo, Z; Liu, S; Pearson, KJ; Xie, Z | 1 |
| Ibrahim, HN; Issa, N; Jackson, S; Kasiske, BL; Kukla, A; Matas, AJ; Mauer, M; Najafian, B; Ortiz, F; Reule, SA | 1 |
| Gai, L; Xie, Y; Yan, M | 1 |
| Date, T; Fujisaki, M; Nagoshi, T; Nishikawa, T; Yoshimura, M | 1 |
| Crestani, S; da Silva-Santos, JE; Gasparotto Júnior, A; Marques, MC; Sullivan, JC; Webb, RC | 1 |
| He, DH; Lin, JX; Lin, LM; Ning, RB; Wang, HJ; Xu, CS; Zhang, LM | 1 |
| Matsuzawa, Y; Nishikawa, T; Omura, M; Saito, J; Suematsu, S | 1 |
| Adams-Huet, B; Molina, C; Nguyen, M; Toto, RD; Van Buren, PN | 1 |
| Balakrishnan, P; Chen, YM; Chueh, SC; Hsein, YC; Kuo, CC; Wang, MJ; Wu, KD; Wu, VC | 1 |
| Dopona, EP; Furukawa, LN; Heimann, JC; Katayama, IA; Oliveira, IB; Pereira, RC; Shimizu, MH | 1 |
| Argiolas, G; Barlassina, C; Boerwinkle, E; Braga, D; Carpini, SD; Chapman, AB; Chittani, M; Citterio, L; Condorelli, G; Cooper-Dehoff, RM; Cusi, D; Dominiczak, AF; Donner, KM; Frau, F; Fresu, G; Glorioso, N; Glorioso, V; Gong, Y; Hiltunen, TP; Johnson, JA; Kontula, KK; Lanzani, C; Manunta, P; Melander, O; Ortu, MF; Padmanabhan, S; Piras, DA; Pozzoli, S; Rivera, NV; Salvi, E; Simonini, M; Trimarco, B; Troffa, C; Turner, ST; Velayutham, D; Zaninello, R | 1 |
| Barhoumi, T; Briet, M; Coelho, SC; Coffman, TM; Mian, MOR; Ouerd, S; Paradis, P; Rautureau, Y; Schiffrin, EL | 1 |
| Bindels, RJ; de Borst, MH; de Jong, MA; Hillebrands, JL; Hoenderop, JG; Mencke, R; Mirkovic, K; Navis, G; van den Born, J; Vervloet, MG | 1 |
| Fang, P; Geng, J; Li, Z; Liu, Q; Lu, D; Shan, Q; Wang, K; Wang, S; Wang, Y; Zhang, Q | 1 |
| Fang, H; Lu, A; Xu, C; Yang, T; Zhou, L | 1 |
| Lindberg, C; Manhem, K; Peker, Y; Rosengren, A; Thunström, E; Yucel-Lindberg, T | 1 |
| He, DH; Lin, JX; Xie, Q; Xu, CS; Zhang, LM | 1 |
| Arias, SCA; Breyer, MD; Fanelli, C; Fujihara, CK; Jadhav, PK; Kowala, MC; Krieger, JE; Malheiros, DM; Montrose-Rafizadeh, C; Rodrigues, MV; Sena, CR; Zatz, R | 1 |
| Daneshtalab, N; Smeda, JS | 1 |
| Chianca, D; de Abreu, ARR; de Menezes, RCA; de Souza, AMA; Ji, H; Mesquita, LBT; Pai, AV; Sandberg, K; West, CA | 1 |
| de Souza, AMA; Ji, H; Sandberg, K; West, CA; Wu, X | 1 |
6 review(s) available for losartan and aldosterone
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
Angiotensin II receptor blockers: equal or preferred substitutes for ACE inhibitors?
Topics: Acrylates; Aldosterone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Drug Therapy, Combination; Heart; Humans; Hypertension; Imidazoles; Irbesartan; Kidney; Losartan; Renin-Angiotensin System; Telmisartan; Tetrazoles; Thiophenes | 2000 |
Angiotensin receptor blockers and aldosterone antagonists in chronic heart failure.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Captopril; Heart Failure; Humans; Hypertension; Losartan; Mineralocorticoid Receptor Antagonists; Renin-Angiotensin System; Spironolactone; Tetrazoles; Valine; Valsartan | 2001 |
Clinical implications of aldosterone blockade.
Topics: Aldosterone; Antihypertensive Agents; Black People; Blood Pressure; Cardiovascular Diseases; Clinical Trials as Topic; Eplerenone; Humans; Hypertension; Kidney Diseases; Losartan; Mineralocorticoid Receptor Antagonists; Potassium; Renin-Angiotensin System; Spironolactone | 2002 |
Angiotensin receptor blockers: new considerations in their mechanism of action.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Hemodynamics; Humans; Irbesartan; Losartan; Sympathetic Nervous System; Tetrazoles | 2006 |
Clinical pharmacology of the angiotensin II receptor antagonist losartan potassium in healthy subjects.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Glomerular Filtration Rate; Heart Rate; Humans; Losartan; Renin; Renin-Angiotensin System; Uric Acid | 1995 |
45 trial(s) available for losartan and aldosterone
| Article | Year |
|---|---|
Drug concentration response relationships in normal volunteers after oral administration of losartan, an angiotensin II receptor antagonist.
Topics: Administration, Oral; Adult; Aldosterone; Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biotransformation; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Humans; Imidazoles; Losartan; Male; Reference Values; Renin; Tetrazoles | 1992 |
Effects of losartan on the renin-angiotensin-aldosterone axis in essential hypertension.
Topics: Aldosterone; Angiotensin II; Biphenyl Compounds; Blood Pressure; Creatinine; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Renin; Renin-Angiotensin System; Tetrazoles | 1995 |
Haemodynamic and renal responses to oral losartan potassium during salt depletion or salt repletion in normal human volunteers.
Topics: Adult; Aldosterone; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Creatinine; Double-Blind Method; Electrolytes; Furosemide; Heart Rate; Hemodynamics; Humans; Imidazoles; Kidney; Losartan; Male; Renin; Sodium; Tetrazoles | 1995 |
Dose-ranging study of the angiotensin type I receptor antagonist losartan (DuP753/MK954), in salt-deplete normal man.
Topics: Adult; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Pressure; Diet, Sodium-Restricted; Dose-Response Relationship, Drug; Double-Blind Method; Electrolytes; Furosemide; Heart Rate; Humans; Imidazoles; Losartan; Male; Natriuresis; Renin; Sodium; Tetrazoles | 1993 |
Hemodynamic and humoral effects of the angiotensin II antagonist losartan in essential hypertension.
Topics: Adult; Aldosterone; Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Body Weight; Female; Heart Rate; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Neurotransmitter Agents; Nifedipine; Norepinephrine; Renin; Tetrazoles | 1994 |
Salt-dependent renal effects of an angiotensin II antagonist in healthy subjects.
Topics: Adult; Aldosterone; Angiotensin II; Biphenyl Compounds; Blood Pressure; Double-Blind Method; Electrolytes; Glomerular Filtration Rate; Hemodynamics; Humans; Imidazoles; Kidney; Lithium; Losartan; Male; Renal Circulation; Renin; Sodium, Dietary; Tetrazoles; Uric Acid; Urine | 1993 |
Pharmacokinetics and biochemical efficacy after single and multiple oral administration of losartan, an orally active nonpeptide angiotensin II receptor antagonist, in humans.
Topics: Administration, Oral; Adult; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Pressure; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Heart Rate; Humans; Imidazoles; Losartan; Male; Middle Aged; Renin; Tetrazoles | 1993 |
Renal effects of angiotensin I-receptor blockade and angiotensin convertase inhibition in man.
Topics: Adult; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Compounds; Blood Pressure; Double-Blind Method; Drug Synergism; Enalapril; Humans; Imidazoles; Kidney; Losartan; Male; Peptidyl-Dipeptidase A; Regional Blood Flow; Renal Circulation; Renin; Tetrazoles | 1996 |
Losartan blocks aldosterone and renal vascular responses to angiotensin II in humans.
Topics: Aldosterone; Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Interactions; Humans; Imidazoles; Infusions, Intravenous; Kidney; Losartan; Male; Renal Circulation; Renin; Sodium Chloride, Dietary; Tetrazoles | 1996 |
The effects of angiotensin II receptor blockade with losartan on systemic blood pressure and renal and extrarenal prostaglandin synthesis in women with essential hypertension.
Topics: Aged; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Female; Humans; Hypertension; Imidazoles; Kidney; Losartan; Middle Aged; Prostaglandins; Renin; Single-Blind Method; Tetrazoles; Uric Acid | 1995 |
Additive effects of losartan and enalapril on blood pressure and plasma active renin.
Topics: Adolescent; Adult; Aldosterone; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Enalapril; Heart Rate; Humans; Hydrocortisone; Imidazoles; Losartan; Male; Peptidyl-Dipeptidase A; Renin; Tetrazoles; Time Factors | 1997 |
Haemodynamic and endocrine effects of type 1 angiotensin II receptor blockade in patients with hypoxaemic cor pulmonale.
Topics: Aged; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Cross-Over Studies; Double-Blind Method; Echocardiography, Doppler, Pulsed; Female; Humans; Hypertension, Pulmonary; Imidazoles; Losartan; Lung Diseases, Obstructive; Male; Pulmonary Heart Disease; Tetrazoles; Vascular Resistance | 1997 |
AT1 receptor blockade and the sympathoadrenal response to insulin-induced hypoglycemia in humans.
Topics: Adrenal Medulla; Adult; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Glucose; Blood Pressure; Catecholamines; Female; Heart Rate; Humans; Imidazoles; Insulin; Losartan; Male; Receptor, Angiotensin, Type 1; Regional Blood Flow; Renin; Sympathetic Nervous System; Tetrazoles | 1997 |
Angiotensin II type 1 receptor gene polymorphism predicts response to losartan and angiotensin II.
Topics: Adult; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Pressure; Female; Glomerular Filtration Rate; Humans; Kidney; Losartan; Male; Polymorphism, Single Nucleotide; Predictive Value of Tests; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renal Circulation; Vasoconstrictor Agents | 1999 |
Pharmacokinetics and blood pressure response of losartan in end-stage renal disease.
Topics: Adult; Aldosterone; Antihypertensive Agents; Area Under Curve; Blood Pressure; Female; Half-Life; Humans; Hypertension, Renal; Kidney Failure, Chronic; Losartan; Male; Renal Dialysis; Renin | 2000 |
Add-on angiotensin receptor blockade with maximized ACE inhibition.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aldosterone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cardiac Output; Cross-Over Studies; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Humans; Kidney Failure, Chronic; Lisinopril; Losartan; Male; Middle Aged; Proteinuria; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renal Circulation; Renin; Urine | 2001 |
Coadministration of losartan and enalapril exerts additive antiproteinuric effect in IgA nephropathy.
Topics: Adult; Aldosterone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Cohort Studies; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Enalapril; Female; Glomerulonephritis, IGA; Humans; Linear Models; Losartan; Male; Proteinuria; Renin; Treatment Outcome | 2001 |
Effect of short-term losartan treatment in patients with primary aldosteronism and essential hypertension.
Topics: Administration, Oral; Age Factors; Aldosterone; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Pressure; Endothelial Growth Factors; Female; Humans; Hyperaldosteronism; Hypertension; Kallikreins; Losartan; Lymphokines; Male; Matched-Pair Analysis; Middle Aged; Plasma Kallikrein; Receptor, Angiotensin, Type 1; Renin; Sex Factors; Time Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
A low-sodium diet potentiates the effects of losartan in type 2 diabetes.
Topics: Albuminuria; Aldosterone; Angiotensin II; Antihypertensive Agents; Blood Glucose; Blood Pressure; Creatinine; Diabetes Mellitus, Type 2; Diet, Sodium-Restricted; Drug Synergism; Female; Hemodynamics; Humans; Losartan; Male; Middle Aged; Placebos; Renal Circulation; Renin; Sodium | 2002 |
The mechanism of improved sodium homeostasis of low-dose losartan in preascitic cirrhosis.
Topics: Aldosterone; Antihypertensive Agents; Ascites; Blood Volume; Homeostasis; Humans; Liver Cirrhosis; Losartan; Male; Middle Aged; Posture; Renal Circulation; Renin; Sodium, Dietary | 2002 |
Influence of AT1 receptor blockade on blood pressure, renal haemodynamics and hormonal responses to intravenous angiotensin II infusion in hypertensive patients.
Topics: Adult; Aged; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Hemodynamics; Humans; Hypertension; Infusions, Intravenous; Losartan; Male; Middle Aged; Receptor, Angiotensin, Type 1; Renal Circulation; Renin; Tetrazoles; Valine; Valsartan | 2002 |
Angiotensin II AT1 receptor antagonism prevents detrimental renal actions of acute diuretic therapy in human heart failure.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Cross-Over Studies; Diuretics; Double-Blind Method; Drug Therapy, Combination; Furosemide; Glomerular Filtration Rate; Heart Failure; Humans; Kidney; Kidney Diseases; Losartan; Receptor, Angiotensin, Type 1; Renal Circulation; Renin | 2003 |
Efficacy and tolerability of eplerenone and losartan in hypertensive black and white patients.
Topics: Adult; Aldosterone; Analysis of Variance; Angiotensin Receptor Antagonists; Antihypertensive Agents; Black People; Blood Pressure; Double-Blind Method; Eplerenone; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Renin; Renin-Angiotensin System; Spironolactone; Treatment Outcome; White People | 2003 |
Effect of amlodipine, quinapril, and losartan on pulse wave velocity and plasma collagen markers in patients with mild-to-moderate arterial hypertension.
Topics: Adult; Aldosterone; Amlodipine; Antihypertensive Agents; Biomarkers; Blood Flow Velocity; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Collagen; Compliance; Echocardiography; Elasticity; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Pulsatile Flow; Quinapril; Severity of Illness Index; Tetrahydroisoquinolines | 2003 |
Combined converting enzyme inhibition and angiotensin receptor blockade reduce proteinuria greater than converting enzyme inhibition alone: insights into mechanism.
Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Disease Progression; Drug Therapy, Combination; Female; Humans; Kidney Diseases; Losartan; Male; Middle Aged; Proteinuria; Renin | 2003 |
Increased plasma concentration of natriuretic peptides by selective beta1-blocker bisoprolol.
Topics: Adolescent; Adult; Aged; Aldosterone; Bisoprolol; Blood Pressure; Catecholamines; Cross-Over Studies; Double-Blind Method; Female; Heart Rate; Humans; Losartan; Male; Middle Aged; Natriuretic Peptides; Netherlands; Renin | 2003 |
Rationale for the use of combination angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker therapy in heart failure.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Drug Synergism; Drug Therapy, Combination; Exercise Tolerance; Female; Heart Failure; Heart Function Tests; Humans; Losartan; Male; Middle Aged; Natriuretic Peptide, Brain; Receptors, Angiotensin; Renin; Tetrazoles; Valine; Valsartan | 2004 |
Aldosterone escape during blockade of the renin-angiotensin-aldosterone system in diabetic nephropathy is associated with enhanced decline in glomerular filtration rate.
Topics: Adult; Albuminuria; Aldosterone; Antihypertensive Agents; Blood Pressure; Creatinine; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Dietary Proteins; Female; Glomerular Filtration Rate; Glycated Hemoglobin; Humans; Losartan; Male; Middle Aged; Potassium; Renin-Angiotensin System; Sodium | 2004 |
Dual blockade of angiotensin II with enalapril and losartan reduces proteinuria in hypertensive patients with type 2 diabetes.
Topics: Aged; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; C-Reactive Protein; Cystatin C; Cystatins; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Enalapril; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Natriuretic Peptide, Brain; Proteinuria; Transforming Growth Factor beta | 2006 |
Aldosterone breakthrough during therapy with angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in proteinuric patients with immunoglobulin A nephropathy.
Topics: Adult; Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Drug Therapy, Combination; Female; Glomerulonephritis, IGA; Heart Failure; Humans; Losartan; Male; Middle Aged; Prospective Studies; Proteinuria; Thiazepines | 2006 |
The spironolactone, amiloride, losartan, and thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio.
Topics: Aged; Aldosterone; Amiloride; Bendroflumethiazide; Cross-Over Studies; Double-Blind Method; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Renin; Single-Blind Method; Sodium Chloride Symporter Inhibitors; Spironolactone | 2007 |
Renal effects of urodilatin in healthy subjects are independent of blockade of the cyclooxygenase and angiotensin II receptor.
Topics: Adult; Aldosterone; Angiotensin Receptor Antagonists; Atrial Natriuretic Factor; Blood Pressure; Cross-Over Studies; Cyclic GMP; Diuresis; Diuretics; Glomerular Filtration Rate; Heart Rate; Hematocrit; Humans; Indomethacin; Kidney; Kidney Function Tests; Lithium; Losartan; Male; Natriuresis; Peptide Fragments; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Receptors, Angiotensin; Renal Plasma Flow, Effective; Renin; Single-Blind Method | 2008 |
Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan.
Topics: Adult; Aged; Aldosterone; Antihypertensive Agents; Blood Pressure; Cross-Over Studies; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Lipids; Losartan; Male; Middle Aged; Patient Compliance; Potassium; Proteinuria; Renin; Renin-Angiotensin System; Serum Albumin; Sodium Chloride, Dietary; Uric Acid | 2008 |
Effect of pentoxifylline in addition to losartan on proteinuria and GFR in CKD: a 12-month randomized trial.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Blood Glucose; Blood Pressure; Chemokine CCL2; Chronic Disease; Disease Progression; Drug Therapy, Combination; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Kidney Diseases; Losartan; Male; Middle Aged; Pentoxifylline; Phosphodiesterase Inhibitors; Proteinuria; Tumor Necrosis Factor-alpha | 2008 |
CYP2C9 genotype modifies activity of the renin-angiotensin-aldosterone system in hypertensive men.
Topics: Adult; Aldosterone; Amlodipine; Antihypertensive Agents; Aryl Hydrocarbon Hydroxylases; Bisoprolol; Cross-Over Studies; Cytochrome P-450 CYP2C9; Double-Blind Method; Drug Resistance; Electrolytes; Gene Frequency; Genotype; Humans; Hypertension, Renal; Losartan; Male; Middle Aged; Placebos; Renin; Renin-Angiotensin System | 2009 |
Safety and benefits of a tablet combining losartan and hydrochlorothiazide in Japanese diabetic patients with hypertension.
Topics: Adult; Albuminuria; Aldosterone; Antihypertensive Agents; Asian People; Blood Pressure; Cross-Over Studies; Diabetes Complications; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Natriuretic Peptide, Brain; Renin; Tablets; Treatment Outcome | 2009 |
Role of plasma aldosterone concentration in regression of left-ventricular mass following antihypertensive medication.
Topics: Adult; Aged; Aldosterone; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Losartan; Male; Middle Aged; Ventricular Dysfunction, Left | 2011 |
Suppression of aldosterone mediates regression of left ventricular hypertrophy in patients with hypertension.
Topics: Aldosterone; Amides; Antihypertensive Agents; Blood Pressure; Demography; Female; Fumarates; Heart Ventricles; Humans; Hypertension; Hypertrophy, Left Ventricular; Losartan; Male; Middle Aged; Organ Size; Systole | 2011 |
Influence of diabetes on efficacy of aliskiren, losartan or both on left ventricular mass regression.
Topics: Aldosterone; Amides; Antihypertensive Agents; Biomarkers; Blood Pressure; Diabetes Complications; Female; Fumarates; Heart Ventricles; Humans; Hypertrophy, Left Ventricular; Losartan; Male; Middle Aged; Organ Size; Renin; Treatment Outcome | 2012 |
Do high doses of AT(1)-receptor blockers attenuate central sympathetic outflow in humans with chronic heart failure?
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Female; Heart Failure; Humans; Losartan; Male; Middle Aged; Norepinephrine; Sympathetic Nervous System | 2013 |
Angiotensin II, independent of plasma renin activity, contributes to the hypertension of autonomic failure.
Topics: Aged; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Captopril; Double-Blind Method; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Orthostatic Intolerance; Pure Autonomic Failure; Renin; Sodium | 2013 |
The renin-aldosterone axis in kidney transplant recipients and its association with allograft function and structure.
Topics: Adult; Albuminuria; Aldosterone; Allografts; Angiotensin II Type 1 Receptor Blockers; Biomarkers; Biopsy; Creatinine; Female; Fibrosis; Glomerular Filtration Rate; Humans; Kidney; Kidney Failure, Chronic; Kidney Transplantation; Losartan; Male; Middle Aged; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Renin; Renin-Angiotensin System; Risk Factors; Time Factors; Treatment Outcome | 2014 |
Potassium handling with dual renin-angiotensin system inhibition in diabetic nephropathy.
Topics: Adult; Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Biomarkers; Creatinine; Diabetic Nephropathies; Diuretics; Drug Therapy, Combination; Female; Humans; Hyperkalemia; Lisinopril; Losartan; Male; Middle Aged; Potassium; Prospective Studies; Renin-Angiotensin System; Risk Factors; Sodium; Spironolactone; Texas; Time Factors; Treatment Outcome | 2014 |
TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives.
Topics: Adult; Aged; Aldosterone; Antihypertensive Agents; Blood Pressure; Case-Control Studies; Dioxygenases; DNA-Binding Proteins; Essential Hypertension; Genome-Wide Association Study; Humans; Hydrochlorothiazide; Hypertension; Italy; Losartan; Male; Membrane Proteins; Middle Aged; Pharmacogenetics; Proto-Oncogene Proteins; Sodium Chloride Symporter Inhibitors; Systole; Tumor Suppressor Proteins; White People | 2015 |
Neuroendocrine and Inflammatory Responses to Losartan and Continuous Positive Airway Pressure in Patients with Hypertension and Obstructive Sleep Apnea. A Randomized Controlled Trial.
Topics: Aldosterone; Antihypertensive Agents; Blood Pressure; Case-Control Studies; Continuous Positive Airway Pressure; Epinephrine; Female; Humans; Hypertension; Inflammation; Losartan; Male; Middle Aged; Norepinephrine; Prospective Studies; Renin; Sleep Apnea, Obstructive; Sweden; Treatment Outcome | 2016 |
114 other study(ies) available for losartan and aldosterone
| Article | Year |
|---|---|
Angiotensin-II inhibits Na+/K+ pump in rat adrenal glomerulosa cells: possible contribution to stimulation of aldosterone production.
Topics: Aldosterone; Angiotensin II; Animals; Biphenyl Compounds; Calcium; Enzyme Activation; Imidazoles; Ionomycin; Liver; Losartan; Ouabain; Phorbol Esters; Protein Kinase C; Rats; Rats, Inbred Strains; Rubidium; Rubidium Radioisotopes; Sodium; Sodium-Potassium-Exchanging ATPase; Tetrazoles; Zona Fasciculata; Zona Glomerulosa | 1992 |
Effect of angiotensin II on renin production by rat adrenal glomerulosa cells in culture.
Topics: Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; Biphenyl Compounds; Bucladesine; Cells, Cultured; Cyclic AMP; Female; Imidazoles; Losartan; Potassium; Rats; Rats, Inbred Strains; Renin; Tetrazoles; Zona Glomerulosa | 1992 |
Role of angiotensin II receptor subtypes on the regulation of aldosterone secretion in the adrenal glomerulosa zone in the rat.
Topics: Aldosterone; Angiotensin II; Animals; Biphenyl Compounds; Cells, Cultured; Cyclic AMP; Dithiothreitol; Imidazoles; Inositol Phosphates; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Secretory Rate; Signal Transduction; Sodium, Dietary; Tetrazoles; Zona Glomerulosa | 1992 |
In vitro pharmacology of a nonpeptidic angiotensin II receptor antagonist, SC-51316.
Topics: Adrenal Cortex; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cell Membrane; Female; Imidazoles; Kidney; Losartan; Muscle, Smooth, Vascular; Rats; Receptors, Angiotensin; Renin; Tetrazoles; Triazoles; Uterus | 1992 |
In vitro pharmacology of L-158,809, a new highly potent and selective angiotensin II receptor antagonist.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Binding, Competitive; Biphenyl Compounds; Brain; Cell Membrane; Culture Techniques; Humans; Imidazoles; Losartan; Macaca mulatta; Muscle, Smooth, Vascular; Rabbits; Rats; Species Specificity; Tetrazoles | 1992 |
In vivo pharmacology of L-158,809, a new highly potent and selective nonpeptide angiotensin II receptor antagonist.
Topics: Administration, Oral; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Female; Imidazoles; Injections, Intravenous; Losartan; Macaca mulatta; Male; Pressoreceptors; Pyridines; Rats; Rats, Inbred Strains; Tetrazoles | 1992 |
Angiotensin II receptor subtypes in renal cortex of rats and rhesus monkeys.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding, Competitive; Biphenyl Compounds; Blood Pressure; Enalaprilat; Heart Rate; Imidazoles; Iodine Radioisotopes; Kidney Cortex; Losartan; Macaca mulatta; Male; Pyridines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Renin; Tetrazoles | 1991 |
Angiotensin II receptor subtypes and biological responses in the adrenal cortex and medulla.
Topics: Adrenal Cortex; Adrenal Medulla; Aldosterone; Angiotensin II; Animals; Binding Sites; Biphenyl Compounds; Cattle; Cyclic AMP; Imidazoles; In Vitro Techniques; Losartan; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles; Zona Glomerulosa | 1991 |
Effects of angiotensin subtype 1 and subtype 2 receptor antagonists in normotensive versus hypertensive rats.
Topics: Aldosterone; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Hypertension; Imidazoles; Infusions, Intravenous; Losartan; Mesentery; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Receptors, Angiotensin; Tetrazoles; Vasoconstriction | 1991 |
Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2).
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Dose-Response Relationship, Drug; Drinking; Epinephrine; Heart Rate; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles; Vasoconstriction | 1990 |
Two distinct angiotensin II receptor binding sites in rat adrenal revealed by new selective nonpeptide ligands.
Topics: Adrenal Glands; Aldosterone; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Azoles; Binding, Competitive; Biphenyl Compounds; Cell Membrane; Dithiothreitol; Imidazoles; In Vitro Techniques; Ligands; Losartan; Pyridines; Rats; Receptors, Angiotensin; Saralasin | 1990 |
In vivo pharmacology of L-159,913, a new highly potent and selective nonpeptide angiotensin II receptor antagonist.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Dogs; Female; Hypertension; Imidazoles; Kidney; Losartan; Macaca mulatta; Male; Natriuresis; Pan troglodytes; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin; Tetrazoles; Triazoles | 1995 |
Glucocorticoids but not mineralocorticoids modulate endothelin-1 and angiotensin II binding in SHR vascular smooth muscle cells.
Topics: Aldosterone; Androstanols; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cells, Cultured; Endothelin Receptor Antagonists; Endothelins; Glucocorticoids; Hypertension; Imidazoles; Losartan; Male; Mifepristone; Muscle, Smooth, Vascular; Peptides, Cyclic; Rats; Rats, Inbred SHR; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Tetrazoles; Viper Venoms | 1995 |
In vivo pharmacology of a novel AT1 selective angiotensin II receptor antagonist, MK-996.
Topics: Administration, Oral; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Bradykinin; Dogs; Enalapril; Female; Imidazoles; Injections, Intravenous; Losartan; Macaca mulatta; Male; Nitroglycerin; Pan troglodytes; Pyridines; Rats; Rats, Sprague-Dawley; Tetrazoles | 1995 |
Regulation of aldosterone biosynthesis by adrenal renin is mediated through AT1 receptors in renin transgenic rats.
Topics: Adrenal Cortex; Aldosterone; Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Genetically Modified; Antihypertensive Agents; Biphenyl Compounds; Blotting, Northern; Diet, Sodium-Restricted; Gene Expression Regulation, Enzymologic; Imidazoles; Kidney Cortex; Losartan; Male; Mice; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin; Renin-Angiotensin System; RNA, Messenger; Tetrazoles | 1995 |
Tonic neuronal inhibition by AII revealed by iontophoretic application of Losartan, a specific antagonist of AII type-1 receptors.
Topics: Aldosterone; Amygdala; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Desoxycorticosterone; Imidazoles; Iontophoresis; Losartan; Male; Neurons; Preoptic Area; Prosencephalon; Rats; Rats, Wistar; Septum Pellucidum; Tetrazoles | 1994 |
Short-term desensitization of the angiotensin II receptor of bovine adrenal glomerulosa cells corresponds to a shift from a high to a low affinity state.
Topics: Aldosterone; Alkaloids; Angiotensin II; Animals; Biphenyl Compounds; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Imidazoles; Losartan; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Receptors, Angiotensin; Staurosporine; Tetrazoles; Time Factors; Zona Glomerulosa | 1994 |
Effect of losartan and enalapril on renal adaptation sodium restriction in rat.
Topics: Adaptation, Physiological; Aldosterone; Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Diet, Sodium-Restricted; Enalapril; Hemodynamics; Imidazoles; Kallikreins; Kidney; Losartan; Male; Natriuresis; Rats; Rats, Sprague-Dawley; Renal Circulation; Renin-Angiotensin System; Systole; Tetrazoles | 1994 |
The effect of losartan on potassium-stimulated aldosterone secretion in vitro.
Topics: Aldosterone; Angiotensin II; Animals; Biphenyl Compounds; Female; Imidazoles; Losartan; Periodicity; Potassium; Rats; Rats, Sprague-Dawley; Tetrazoles; Zona Glomerulosa | 1994 |
Angiotensin II receptor subtypes on adrenal adenoma in primary hyperaldosteronism.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Autoradiography; Binding, Competitive; Biphenyl Compounds; Humans; Hyperaldosteronism; Imidazoles; Losartan; Male; Middle Aged; Pyridines; Receptors, Angiotensin; Tetrazoles | 1993 |
Haemodynamic and hormonal responses to losartan (DuP753/MK954) infusion during cardiac catheterization in conscious salt-deplete dogs.
Topics: Aldosterone; Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Cardiac Catheterization; Dogs; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Imidazoles; Losartan; Male; Stimulation, Chemical; Tetrazoles | 1993 |
Hormonal and cardiovascular effects of losartan (DuP753), an angiotensin receptor antagonist, in nonhuman primates.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Feedback; Heart Rate; Hormones; Imidazoles; Losartan; Macaca fascicularis; Male; Renin; Sodium; Tetrazoles | 1993 |
Effect of losartan, an angiotensin II receptor antagonist, on response of cortisol and aldosterone to adrenocorticotrophic hormone.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Fasting; Female; Humans; Hydrocortisone; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Tetrazoles | 1995 |
Role of aldosterone in the remnant kidney model in the rat.
Topics: Adrenal Glands; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Body Weight; Disease Models, Animal; Enalapril; Imidazoles; Kidney; Kidney Diseases; Losartan; Male; Mineralocorticoid Receptor Antagonists; Nephrectomy; Organ Size; Rats; Rats, Sprague-Dawley; Spironolactone; Tetrazoles | 1996 |
Ouabain increases aldosterone release from bovine adrenal glomerulosa cells: role of renin-angiotensin system.
Topics: Aldosterone; Angiotensinogen; Animals; Biphenyl Compounds; Calcium; Cattle; Cells, Cultured; Culture Media; Culture Media, Serum-Free; Horses; Imidazoles; Intracellular Membranes; Losartan; Mineralocorticoid Receptor Antagonists; Ouabain; Rats; Renin-Angiotensin System; Sheep; Swine; Tetrazoles; Zona Glomerulosa | 1996 |
Neuronal responses to iontophoretically applied angiotensin II, losartan and aldosterone, as well as gustatory stimuli, in non-anesthetized control and desoxycorticosterone acetate-pretreated rats.
Topics: Aldosterone; Angiotensin II; Animals; Biphenyl Compounds; Cohort Studies; Desoxycorticosterone; Electrophysiology; Imidazoles; Iontophoresis; Losartan; Male; Neural Conduction; Neurons, Afferent; Prosencephalon; Rats; Rats, Wistar; Taste; Tetrazoles | 1996 |
Effects of DOCA pretreatment on neuronal sensitivity and cell responsiveness to angiotensin II, in the bed nucleus of the stria terminalis in the rat.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Desoxycorticosterone; Electrophysiology; Imidazoles; Iontophoresis; Losartan; Male; Pyridines; Rats; Rats, Wistar; Sensitivity and Specificity; Tetrazoles; Thalamic Nuclei | 1996 |
The renin-angiotensin-aldosterone system in experimental mineralocorticoid-salt-induced cardiac fibrosis.
Topics: Aldosterone; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Body Weight; Canrenoic Acid; Cardiomegaly; Collagen; Corticosterone; Epithelium; Fibrosis; Heart; Imidazoles; Indoles; Losartan; Male; Myocardium; Nephrectomy; Organ Size; Perindopril; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Renin-Angiotensin System; Tetrazoles | 1996 |
Characterization of angiotensin II-regulated K+ conductance in rat adrenal glomerulosa cells.
Topics: Aldosterone; Angiotensin II; Animals; Biphenyl Compounds; Cells, Cultured; Cesium; Female; Imidazoles; Ion Transport; Losartan; Membrane Potentials; Nystatin; Patch-Clamp Techniques; Potassium; Potassium Channels; Quinidine; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetrazoles; Zona Glomerulosa | 1997 |
Effects of an angiotensin II antagonist on reperfusion arrhythmias in dogs.
Topics: Aldosterone; Angiotensin Receptor Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Biphenyl Compounds; Creatine Kinase; Dogs; Imidazoles; Losartan; Myocardial Reperfusion; Tachycardia, Ventricular; Tetrazoles; Ventricular Fibrillation | 1997 |
Effect of sympathetic and angiotensin-aldosterone systems on renal salt conservation in the rat.
Topics: Adrenalectomy; Aldosterone; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Body Water; Body Weight; Dexamethasone; Diet, Sodium-Restricted; Diuresis; Electrolytes; Epinephrine; Furosemide; Hematocrit; Homeostasis; Imidazoles; Kidney; Losartan; Male; Norepinephrine; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Sodium, Dietary; Sympathectomy, Chemical; Sympathetic Nervous System; Tetrazoles; Water-Electrolyte Balance | 1997 |
Angiotensin-responsive adrenal glomerulosa cell proteins: characterization by protease mapping, species comparison, and specific angiotensin receptor antagonists.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Bucladesine; Cattle; Cells, Cultured; Chymotrypsin; Imidazoles; Losartan; Male; Methionine; Peptide Mapping; Protein Biosynthesis; Proteins; Pyridines; Rats; Rats, Sprague-Dawley; Species Specificity; Sulfur Radioisotopes; Tetrazoles; Zona Glomerulosa | 1997 |
Mechanisms in the pressor effects of hepatic portal venous fatty acid infusion.
Topics: Acetylcholine; Aldosterone; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Corticosterone; Epinephrine; Fatty Acids, Nonesterified; Heart Rate; Hypertension; Imidazoles; Infusions, Intravenous; Liver; Losartan; Male; Norepinephrine; Oleic Acid; Phenylephrine; Portal Vein; Prazosin; Rats; Rats, Sprague-Dawley; Renin; Serotonin; Sodium Fluoride; Tetrazoles; Time Factors | 1997 |
Opposite feedback control of renin and aldosterone biosynthesis in the adrenal cortex by angiotensin II AT1-subtype receptors.
Topics: Adrenal Cortex; Aldosterone; Animals; Biphenyl Compounds; Feedback; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin; RNA, Messenger; Tetrazoles | 1997 |
Local upregulation of colonic angiotensin II receptors enhances potassium excretion in chronic renal failure.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Colon; Imidazoles; Kidney Failure, Chronic; Losartan; Male; Potassium; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Rubidium Radioisotopes; Up-Regulation | 1998 |
Acute sodium depletion modifies septo-preoptic neuron sensitivities to neurohormones.
Topics: Aldosterone; Angiotensin II; Angiotensins; Animals; Imidazoles; Losartan; Male; Neurons; Preoptic Area; Pyridines; Rats; Rats, Wistar; Septum Pellucidum; Sodium | 1998 |
Distribution and functional significance of angiotensin-II AT1- and AT2-receptor subtypes in the rat adrenal gland.
Topics: Adrenal Glands; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Autoradiography; Catecholamines; Imidazoles; Iodine Radioisotopes; Losartan; Male; Oligopeptides; Osmolar Concentration; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 1998 |
The AT2 receptor-mediated stimulation of adrenal catecholamine release may potentiate the AT1 receptor-mediated aldosterone secretagogue action of angiotensin-II in rats.
Topics: Adrenal Glands; Aldosterone; Alprenolol; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Catecholamines; Cells, Cultured; Chromaffin Cells; Culture Techniques; Dose-Response Relationship, Drug; Imidazoles; Losartan; Male; Osmolar Concentration; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Zona Glomerulosa | 1998 |
Differential effects of angiotensin II on cardiac cell proliferation and intramyocardial perivascular fibrosis in vivo.
Topics: Aldosterone; Angiotensin II; Animals; Arterioles; Blood Pressure; Cell Division; Collagen; Coronary Vessels; Endothelium, Vascular; Fibrosis; Losartan; Male; Myocardium; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin | 1998 |
Losartan and angiotensin II inhibit aldosterone production in anephric rats via different actions on the intraadrenal renin-angiotensin system.
Topics: Adrenal Glands; Aldosterone; Angiotensin II; Animals; Kidney; Losartan; Male; Membranes; Mineralocorticoid Receptor Antagonists; Nephrectomy; Rats; Rats, Sprague-Dawley; Renin; Renin-Angiotensin System | 1999 |
Local renin-angiotensin system is involved in K+-induced aldosterone secretion from human adrenocortical NCI-H295 cells.
Topics: Adrenal Cortex; Aldosterone; Angiotensinogen; Captopril; Cells, Cultured; Humans; Losartan; Peptidyl-Dipeptidase A; Potassium; Renin; Renin-Angiotensin System | 1999 |
Angiotensin II negatively modulates L-type calcium channels through a pertussis toxin-sensitive G protein in adrenal glomerulosa cells.
Topics: Aldosterone; Angiotensin II; Animals; Calcium; Calcium Channels; Calcium Channels, L-Type; Cattle; Cells, Cultured; GTP-Binding Proteins; Losartan; Patch-Clamp Techniques; Pertussis Toxin; Potassium; Virulence Factors, Bordetella; Zona Glomerulosa | 1999 |
Comparative effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor antagonism on plasma fibrinolytic balance in humans.
Topics: Adult; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Data Interpretation, Statistical; Diet, Sodium-Restricted; Female; Fibrinolysis; Heart Rate; Humans; Isoquinolines; Losartan; Male; Plasminogen Activator Inhibitor 1; Quinapril; Renin; Renin-Angiotensin System; Tetrahydroisoquinolines; Tissue Plasminogen Activator | 1999 |
Effects of losartan on low-density lipoprotein apheresis.
Topics: Aldosterone; Antihypertensive Agents; Bradykinin; Combined Modality Therapy; Follow-Up Studies; Humans; Hyperlipoproteinemia Type II; Lipoproteins, LDL; Losartan; Male; Middle Aged; Plasmapheresis; Renin; Treatment Outcome | 1999 |
Neuropeptide Y enhances potassium excretion by mechanisms distinct from those controlling sodium excretion.
Topics: Aldosterone; Animals; Bradykinin; Humans; Indomethacin; Losartan; Male; Neuropeptide Y; Nifedipine; Potassium; Rats; Rats, Wistar; Sodium | 2000 |
Aldosterone mediates angiotensin II-stimulated rat vascular smooth muscle cell proliferation.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Cell Division; Cells, Cultured; Cytochrome P-450 CYP11B2; Drug Synergism; Losartan; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Spironolactone; Stimulation, Chemical | 2000 |
Role of adrenal renin-angiotensin system in the control of aldosterone secretion in sodium-restricted rats.
Topics: Adrenal Glands; Aldosterone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Diet, Sodium-Restricted; Losartan; Male; Potassium; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Saralasin | 2000 |
Effect of angiotensin II blockade on renal injury in mineralocorticoid-salt hypertension.
Topics: Administration, Oral; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Disease Models, Animal; Enalapril; Hypertension, Renal; Kidney; Kidney Function Tests; Losartan; Male; Nephrectomy; Proteinuria; Rats; Rats, Wistar; Renal Insufficiency; Sodium Chloride | 2000 |
Regulation of the myocardial endothelin system by angiotensin-II and losartan.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Endothelin-1; Endothelins; Gene Expression Regulation; Losartan; Male; Myocardium; Protein Precursors; Rats; Rats, Wistar; Receptor, Endothelin B; Receptors, Endothelin; RNA, Messenger | 2000 |
Acid-base and endocrine effects of aldosterone and angiotensin II inhibition in metabolic acidosis in human patients.
Topics: Acid-Base Equilibrium; Acidosis; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Chronic Disease; Electrolytes; Female; Humans; Hydrocortisone; Losartan; Male; Nitrogen; Spironolactone | 2000 |
Effect of oral contraceptives on the renin angiotensin system and renal function.
Topics: Adult; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Blood Pressure; Contraceptives, Oral; Female; Glomerular Filtration Rate; Humans; Inulin; Kidney; Losartan; p-Aminohippuric Acid; Premenopause; Renal Circulation; Renin; Renin-Angiotensin System; Vascular Resistance | 2001 |
Zonal differentiation in the rat adrenal cortex.
Topics: Adrenal Cortex; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antigens; Corticosterone; Immunohistochemistry; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Losartan; Membrane Proteins; Potassium; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Repressor Proteins; Time Factors; Tissue Distribution; Zona Fasciculata; Zona Glomerulosa | 2000 |
Effects of losartan on blood pressure and humoral factors in a patient who suffered from anaphylactoid reactions when treated with ACE inhibitors during LDL apheresis.
Topics: Aldosterone; Anaphylaxis; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Component Removal; Blood Pressure; Bradykinin; Cholesterol, LDL; Humans; Hypotension; Losartan; Male; Middle Aged; Oligopeptides; Receptor, Angiotensin, Type 1; Renin | 2001 |
In situ demonstration of angiotensin-dependent and independent pathways for hyperaldosteronism during chronic extracellular fluid volume depletion.
Topics: Adrenal Glands; Aldosterone; Angiotensin Receptor Antagonists; Angiotensins; Animals; Antihypertensive Agents; Chimera; Cytochrome P-450 CYP11B2; Diet, Sodium-Restricted; Female; In Situ Hybridization; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Potassium; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Up-Regulation; Water-Electrolyte Balance | 2001 |
Effects of long-term enalapril and losartan therapy of hypertension on cardiovascular aldosterone.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Cardiovascular System; Drug Administration Schedule; Enalapril; Hypertension; Losartan; Mesenteric Arteries; Myocardium; Rats; Rats, Inbred SHR; Rats, Wistar; Receptor, Angiotensin, Type 1; Reference Values | 2001 |
Calcineurin inhibition attenuates mineralocorticoid-induced cardiac hypertrophy.
Topics: Aldosterone; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Atrial Natriuretic Factor; Body Weight; Calcineurin; Calcineurin Inhibitors; Cardiomegaly; Collagen Type III; Cyclosporine; Enzyme Inhibitors; Fibrosis; Heart; Immunosuppressive Agents; Losartan; Male; Mineralocorticoids; Myocardium; Nephrectomy; Organ Size; Rats; Rats, Inbred WKY; RNA, Messenger; Sodium Chloride, Dietary; Tacrolimus | 2002 |
Effects of antihypertensive therapy on intrarenal angiotensin and bradykinin levels in experimental renal insufficiency.
Topics: Aldosterone; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Bradykinin; Creatinine; Enalapril; Kidney; Losartan; Male; Nephrectomy; Nifedipine; Proteinuria; Rats; Rats, Wistar; Renin; Renin-Angiotensin System; Vasodilator Agents | 2002 |
Losartan treatment and left ventricular filling during volume loading in patients with dilated cardiomyopathy.
Topics: Adult; Aldosterone; Analysis of Variance; Anti-Arrhythmia Agents; Antihypertensive Agents; Blood Flow Velocity; Cardiomyopathy, Dilated; Case-Control Studies; Echocardiography; Female; Humans; Losartan; Male; Middle Aged; Mitral Valve; Myocardial Contraction; Pulmonary Circulation; Renin; Ventricular Function, Left | 2002 |
Effects of losartan and benazepril on abnormal circadian blood pressure rhythm and target organ damage in SHRSP.
Topics: Aldosterone; Animals; Antihypertensive Agents; Benzazepines; Blood Pressure; Cardiomegaly; Circadian Rhythm; Collagen; Heart Rate; Hypertension; Kidney; Losartan; Male; Organ Size; Rats; Rats, Inbred SHR; Renin; Urine | 2002 |
Dysregulation of angiotensin II synthesis is associated with salt sensitivity in the spontaneous hypertensive rat.
Topics: Aldosterone; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Blood Pressure; Hypertension; Losartan; Male; Peptidyl-Dipeptidase A; Rats; Rats, Inbred SHR; Receptors, Angiotensin; Renin; Sodium Chloride, Dietary | 2002 |
Effects of long-term enalapril and losartan therapy of heart failure on cardiovascular aldosterone.
Topics: Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiac Output, Low; Cardiomegaly; Cardiovascular System; Chronic Disease; Enalapril; Losartan; Male; Mesenteric Arteries; Myocardial Infarction; Rats; Rats, Wistar | 2002 |
Losartan attenuates renal vasoconstriction in response to acute unilateral ureteral occlusion in pigs.
Topics: Acute Disease; Aldosterone; Angiotensin II; Animals; Glomerular Filtration Rate; Kidney; Losartan; Pelvis; Pressure; Renal Circulation; Swine; Ureteral Obstruction; Vascular Resistance; Vasoconstriction | 2002 |
Mineralocorticoid and angiotensin receptor antagonism during hyperaldosteronemia.
Topics: Aldosterone; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Eplerenone; Heart Ventricles; Hyperaldosteronism; Losartan; Magnesium; Male; Membrane Potentials; Mineralocorticoid Receptor Antagonists; Patch-Clamp Techniques; Potassium; Rabbits; Sodium; Sodium-Potassium-Exchanging ATPase; Spironolactone; Ventricular Function | 2002 |
Effects of angiotensin II receptor antagonists on [(123)I]metaiodobenzylguanidine myocardial imaging findings and neurohumoral factors in chronic heart failure.
Topics: 3-Iodobenzylguanidine; Aged; Aged, 80 and over; Aldosterone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Atrial Natriuretic Factor; Benzimidazoles; Biomarkers; Biphenyl Compounds; Blood Pressure; Creatinine; Echocardiography; Female; Heart; Heart Failure; Humans; Losartan; Male; Middle Aged; Natriuretic Peptide, Brain; Neurotransmitter Agents; Norepinephrine; Potassium; Radionuclide Imaging; Radiopharmaceuticals; Receptors, Angiotensin; Renin; Severity of Illness Index; Statistics as Topic; Stroke Volume; Tetrazoles; Time Factors; Treatment Outcome; Ventricular Dysfunction, Left | 2002 |
Effect of ANG II type I receptor antagonist and ACE inhibitor on vitamin D receptor-null mice.
Topics: Aldosterone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Captopril; Female; Gene Expression; Kidney; Losartan; Male; Mice; Mice, Mutant Strains; Receptor, Angiotensin, Type 1; Receptors, Calcitriol; Renin; Salts; Submandibular Gland; Water; Water-Electrolyte Balance | 2003 |
Hypertension, angiotensin II, aldosterone, and race.
Topics: Aldosterone; Angiotensin Receptor Antagonists; Antihypertensive Agents; Black People; Eplerenone; Humans; Hypertension; Losartan; Mineralocorticoid Receptor Antagonists; Renin; Renin-Angiotensin System; Spironolactone; Treatment Outcome; White People | 2003 |
Effect of losartan on oxidative stress-induced hypertension in Sprague-Dawley rats.
Topics: Aldosterone; Angiotensin II; Animals; Antihypertensive Agents; Aorta; Biomarkers; Blood Pressure; Buthionine Sulfoximine; Cyclic AMP; Cyclic GMP; Dinoprost; Disease Models, Animal; Enzyme Inhibitors; Epoprostenol; F2-Isoprostanes; Glutathione; Heart Rate; Hypertension; Kidney; Losartan; Male; Models, Cardiovascular; Nitric Oxide; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxides; Thromboxane A2; Treatment Outcome | 2003 |
Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development: a possible role for angiotensin-converting enzyme and the receptors for angiotensin II and aldosterone.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Aortic Diseases; Apolipoproteins E; Arteriosclerosis; Cell Line; Enzyme Induction; Eplerenone; Hormone Antagonists; Humans; Lipid Peroxidation; Lipoproteins, LDL; Losartan; Macrophages, Peritoneal; Membrane Proteins; Mice; Mice, Knockout; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Oxidative Stress; Peptidyl-Dipeptidase A; Phosphoproteins; Protein Transport; Ramipril; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; RNA, Messenger; Spironolactone; Superoxides | 2004 |
Involvement of oxidative stress in the profibrotic action of aldosterone. Interaction wtih the renin-angiotension system.
Topics: Aldosterone; Animals; Antihypertensive Agents; Antioxidants; Biomarkers; Blood Pressure; Cyclic N-Oxides; Disease Models, Animal; Endocardium; Endothelium, Vascular; Fibrosis; Infusions, Intra-Arterial; Kidney; Losartan; Male; Models, Cardiovascular; NADP; Nitroprusside; Oxidative Stress; Pericardium; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Renin-Angiotensin System; Spin Labels; Systole; Thiobarbituric Acid Reactive Substances; Vasodilator Agents | 2004 |
Cardioprotective effects of vasopeptidase inhibition vs. angiotensin type 1-receptor blockade in spontaneously hypertensive rats on a high salt diet.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Apoptosis; Autoradiography; Body Weight; Cardiotonic Agents; Connective Tissue Growth Factor; Fibrosis; Hydrochlorothiazide; Hypertension; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Losartan; Male; Myocardium; Organ Size; Protease Inhibitors; Pyridines; Rats; Rats, Inbred SHR; Renin; Sodium Chloride, Dietary; Thiazepines | 2004 |
Inhibition of catecholamine-induced cardiac fibrosis by an aldosterone antagonist.
Topics: Adrenergic beta-Agonists; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Canrenoic Acid; Fibrosis; Heart Failure; Isoproterenol; Losartan; Male; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Myocardium; Rats; Rats, Wistar; Receptors, Adrenergic, beta | 2005 |
Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Adenoviridae; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Aorta; Cell Line, Transformed; Coronary Vessels; Gene Expression Profiling; Gene Expression Regulation; Genes, Reporter; Genetic Vectors; Humans; Hydrocortisone; Losartan; Mammary Tumor Virus, Mouse; Models, Biological; Muscle, Smooth, Vascular; Myocardial Ischemia; Myocytes, Smooth Muscle; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Spironolactone; Transcription, Genetic; Transduction, Genetic | 2005 |
The expression of messenger RNA for ADP-ribosyl cyclase in aldosterone-producing adenomas.
Topics: Adenoma; ADP-ribosyl Cyclase; Adrenal Cortex Neoplasms; Aldosterone; Angiotensins; Case-Control Studies; Cyclic ADP-Ribose; Cytochrome P-450 CYP11B2; Dose-Response Relationship, Drug; Gene Expression; Humans; Imidazoles; In Vitro Techniques; Losartan; Pyridines; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured | 2005 |
Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage.
Topics: Adrenal Glands; Adrenalectomy; Aldosterone; Angiotensin II; Angiotensinogen; Animals; Animals, Genetically Modified; Cytochrome P-450 CYP11B2; Enzyme Inhibitors; Fibrosis; Heart Diseases; Humans; Inflammation; Kidney Diseases; Losartan; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Renin | 2005 |
Low sodium intake induces an increase in renal monoamine oxidase activity in the rat. Involvement of an angiotensin II dependent mechanism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Diet, Sodium-Restricted; Dopamine; Glomerular Filtration Rate; Kidney; Losartan; Male; Monoamine Oxidase; Rats; Rats, Wistar; Sodium | 2005 |
Simvastatin and losartan enhance nitric oxide and reduce oxidative stress in salt-induced hypertension.
Topics: Acetylcholine; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Pressure; Body Weight; Drug Therapy, Combination; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; In Vitro Techniques; Kidney; Losartan; Male; Mesenteric Arteries; Myocardium; Nitric Oxide; Organ Size; Oxidative Stress; Prostaglandins; Rats; Rats, Inbred Dahl; Simvastatin; Sodium Chloride, Dietary; Superoxides; Thromboxane A2; Treatment Outcome; Vasoconstriction; Vasodilator Agents | 2005 |
Remodeling and angiotensin II responses of the uterine arcuate arteries of pregnant rats are altered by low- and high-sodium intake.
Topics: Aldosterone; Angiotensin II; Animals; Arteries; Dose-Response Relationship, Drug; Female; Losartan; Muscle Contraction; Muscle, Smooth, Vascular; Myography; Pregnancy; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System; Sodium Chloride; Sodium, Dietary; Uterus | 2006 |
Reduction of salt sensitivity in stroke-prone spontaneously hypertensive rats administered an AT1 receptor antagonist during suckling.
Topics: Albuminuria; Aldosterone; Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Suckling; Antihypertensive Agents; Biomarkers; Blood Pressure; Disease Models, Animal; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin; Sodium Chloride, Dietary; Stroke; Time Factors | 2006 |
The effect of diet on simvastatin and losartan enhancement of endothelial function.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Diet; Diet, Sodium-Restricted; Dietary Fats; Endothelium, Vascular; Epoprostenol; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Kidney; Lipids; Losartan; Male; Nitric Oxide; Rats; Rats, Inbred SHR; Simvastatin; Sodium, Dietary; Superoxides; Thromboxane A2 | 2007 |
In vivo regulation of AT1a receptor-mediated intracellular uptake of [125I]Val5-ANG II in the kidneys and adrenals of AT1a receptor-deficient mice.
Topics: Adrenal Cortex; Adrenal Glands; Adrenal Medulla; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Captopril; Diuresis; Drinking; Endocytosis; Infusions, Intravenous; Kidney; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Potassium; Protein Isoforms; Receptor, Angiotensin, Type 1; Sodium | 2008 |
A novel adipokine CTRP1 stimulates aldosterone production.
Topics: Adipokines; Aldosterone; Angiotensin II; Animals; Calcium; Cytochrome P-450 CYP11B2; DNA-Binding Proteins; Humans; Hypertension; Losartan; Male; Nuclear Receptor Subfamily 4, Group A, Member 1; Nuclear Receptor Subfamily 4, Group A, Member 2; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured | 2008 |
Letter regarding article by Hood et al, "The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio".
Topics: Aldosterone; Amiloride; Antihypertensive Agents; Bendroflumethiazide; Cross-Over Studies; Double-Blind Method; Humans; Hypertension; Losartan; Sodium Chloride Symporter Inhibitors; Spironolactone | 2008 |
RAS inhibitors decrease apoptosis of acinar cells and increase elimination of pancreatic stellate cells after in the course of experimental chronic pancreatitis induced by dibutyltin dichloride.
Topics: Actins; Aldosterone; Animals; Apoptosis; Captopril; Cell Proliferation; Enalapril; Immunohistochemistry; Lisinopril; Losartan; Male; Organotin Compounds; Pancreas; Pancreatitis, Chronic; Rats; Rats, Inbred Lew; Renin-Angiotensin System | 2008 |
Mechanisms in the PVN mediating local and central sodium-induced hypertension in Wistar rats.
Topics: Aldosterone; Amiloride; Angiotensins; Animals; Antihypertensive Agents; Blood Pressure; Cardiotonic Agents; Cerebrospinal Fluid; Diuretics; Dose-Response Relationship, Drug; Eplerenone; Heart Rate; Hypertension; Injections, Intraventricular; Losartan; Ouabain; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; Sodium; Spironolactone | 2009 |
[Mechanisms of losartan for inhibition of myocardial fibrosis following myocardial infarction in rats].
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Fibrosis; Losartan; Male; Myocardial Infarction; Myocardium; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; RNA, Messenger | 2008 |
Expression of NAD(P)H oxidase subunits and their contribution to cardiovascular damage in aldosterone/salt-induced hypertensive rat.
Topics: Acetophenones; Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Blood Pressure; Hypertension; Kidney; Losartan; Male; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Organ Size; Oxidative Stress; Protein Subunits; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Chloride; Spironolactone; Superoxides | 2008 |
Impairment of the autoregulation of renal hemodynamics and of the pressure-natriuresis relationship precedes the development of hypertension in Cyp1a1-Ren-2 transgenic rats.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cytochrome P-450 CYP1A1; Glomerular Filtration Rate; Hemodynamics; Homeostasis; Hypertension; Indoles; Kidney; Losartan; Male; Natriuresis; Rats; Rats, Transgenic; Receptor, Angiotensin, Type 1; Renal Circulation; Renin; Renin-Angiotensin System; Sodium; Time Factors | 2009 |
Salt-induced cardiac hypertrophy and interstitial fibrosis are due to a blood pressure-independent mechanism in Wistar rats.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Collagen Type I; Collagen Type III; Disease Models, Animal; Drinking; Eating; Echocardiography; Fibrosis; Gene Expression; Heart Ventricles; Hydralazine; Hypertension; Losartan; Male; Myocardium; Potassium; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin; Renin-Angiotensin System; Sodium; Sodium Chloride, Dietary; Transforming Growth Factor beta; Urine | 2010 |
Similar renoprotection after renin-angiotensin-dependent and -independent antihypertensive therapy in 5/6-nephrectomized Ren-2 transgenic rats: are there blood pressure-independent effects?
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Creatinine; Diabetic Nephropathies; Diuretics; Drug Therapy, Combination; Furosemide; Hydrochlorothiazide; Hypertension; Indoles; Kidney Failure, Chronic; Labetalol; Losartan; Proteinuria; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Renin; Renin-Angiotensin System | 2010 |
Adrenal beta-arrestin 1 inhibition in vivo attenuates post-myocardial infarction progression to heart failure and adverse remodeling via reduction of circulating aldosterone levels.
Topics: Adrenal Glands; Aldosterone; Animals; Arrestins; beta-Arrestin 1; beta-Arrestins; Cell Line; Disease Progression; Gene Transfer Techniques; Heart Failure; Humans; Losartan; Myocardial Infarction; Random Allocation; Rats; Receptors, G-Protein-Coupled; Ventricular Remodeling | 2011 |
Aldosterone-induced brain MAPK signaling and sympathetic excitation are angiotensin II type-1 receptor dependent.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Infusions, Intravenous; Infusions, Intraventricular; Losartan; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; RNA, Small Interfering; Sympathetic Nervous System | 2012 |
Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice.
Topics: Aldosterone; Amiloride; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Body Weight; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationship, Drug; Homeostasis; Hypertension; Kidney; Losartan; Male; Mice; Mice, Knockout; Natriuresis; Renin; Serine Endopeptidases; Sodium Channel Blockers; Sodium Chloride, Dietary; Telemetry; Time Factors | 2012 |
Aldosterone does not require angiotensin II to activate NCC through a WNK4-SPAK-dependent pathway.
Topics: Adrenalectomy; Aldosterone; Amiloride; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Diuretics; Dose-Response Relationship, Drug; Hydrochlorothiazide; Kidney; Losartan; Models, Animal; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium Chloride Symporters | 2012 |
Responses to dehydration in the one-humped camel and effects of blocking the renin-angiotensin system.
Topics: Aldosterone; Analysis of Variance; Animals; Arginine Vasopressin; Body Weights and Measures; Camelus; Creatinine; Dehydration; Losartan; Male; Renin-Angiotensin System; Sodium; United Arab Emirates; Urea | 2012 |
Transient prehypertensive treatment in spontaneously hypertensive rats: a comparison of losartan and amlodipine regarding long-term blood pressure, cardiac and renal protection.
Topics: Aldosterone; Amlodipine; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cardiotonic Agents; Collagen; Gene Expression Regulation; Heart Ventricles; Hypertension; Hypertrophy, Left Ventricular; Kidney; Losartan; Male; Natriuretic Peptide, Brain; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Stroke Volume; Transforming Growth Factor beta1; Ultrasonography | 2012 |
Angiotensin II and III metabolism and effects on steroid production in the HAC15 human adrenocortical cell line.
Topics: 3-Hydroxysteroid Dehydrogenases; Adrenal Cortex; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin III; Cell Line; Cytochrome P-450 CYP11B2; Humans; Hydrocortisone; Losartan; Steroid 11-beta-Hydroxylase; Steroid 17-alpha-Hydroxylase | 2013 |
Regression of albuminuria and hypertension and arrest of severe renal injury by a losartan-hydrochlorothiazide association in a model of very advanced nephropathy.
Topics: Acute Kidney Injury; Albuminuria; Aldosterone; Animals; Antihypertensive Agents; Drug Therapy, Combination; Glomerulonephritis; Hydrochlorothiazide; Hypertension; Kidney; Losartan; Male; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Renal Insufficiency, Chronic | 2013 |
Mineralocorticoid receptor agonists induce mouse aortic aneurysm formation and rupture in the presence of high salt.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Aortic Rupture; Apoptosis; Blood Pressure; Desoxycorticosterone; Disease Models, Animal; Elastin; Enalapril; Eplerenone; Losartan; Male; Mice; Mice, Inbred C57BL; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Oxidative Stress; Receptors, Mineralocorticoid; Sodium Chloride, Dietary; Spironolactone; Time Factors | 2013 |
[Effect of angiotensin II and aldosterone on the proliferation of cardiac fibroblasts in rats].
Topics: Aldosterone; Angiotensin II; Animals; Cell Proliferation; Collagen; Fibroblasts; Losartan; Myocardium; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spironolactone | 2013 |
Rapid induction of aldosterone synthesis in cultured neonatal rat cardiomyocytes under high glucose conditions.
Topics: Aldosterone; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Cells, Cultured; Cytochrome P-450 CYP11B2; Gene Expression Regulation, Enzymologic; Glucose; Losartan; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 2013 |
Enhanced angiotensin-converting enzyme activity and systemic reactivity to angiotensin II in normotensive rats exposed to a high-sodium diet.
Topics: Aldosterone; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Pressure; Losartan; Male; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Sodium Chloride, Dietary | 2014 |
Long-term prehypertension treatment with losartan effectively prevents brain damage and stroke in stroke-prone spontaneously hypertensive rats.
Topics: Aldosterone; Amlodipine; Angiotensin II; Animals; Apoptosis; Blood Pressure; Brain; Hypertension; Losartan; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Prehypertension; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Stroke; Superoxide Dismutase; Time Factors | 2014 |
Vascular aldosterone production at the pre-diabetic stage of young Otsuka Long-Evans Tokushima Fatty (OLETF) rats, compared with Long-Evans Tokushima Otsuka (LETO) rats.
Topics: Aldosterone; Angiotensin II; Animals; Aorta; Blood Vessels; Cholesterol, HDL; Cytochrome P-450 CYP11B2; Gene Expression; Losartan; Myocytes, Smooth Muscle; Prediabetic State; Rats; Rats, Inbred OLETF; RNA, Messenger | 2013 |
The value of losartan suppression test in the confirmatory diagnosis of primary aldosteronism in patients over 50 years old.
Topics: Aldosterone; Captopril; Demography; Female; Humans; Hyperaldosteronism; Hypertension; Losartan; Male; Middle Aged; Renin; Reproducibility of Results; ROC Curve | 2015 |
High-salt intake induces cardiomyocyte hypertrophy in rats in response to local angiotensin II type 1 receptor activation.
Topics: Acetylcysteine; Aldosterone; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Cardiomegaly; Heart Rate; Hematocrit; Hydralazine; Losartan; Male; Myocytes, Cardiac; Potassium; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Sodium; Sodium Chloride, Dietary; Thiobarbituric Acid Reactive Substances | 2014 |
Aldosterone-Induced Vascular Remodeling and Endothelial Dysfunction Require Functional Angiotensin Type 1a Receptors.
Topics: Aldosterone; Analysis of Variance; Animals; Disease Models, Animal; Endothelium, Vascular; Hypertension; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Norepinephrine; Oxidative Stress; Random Allocation; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; Reference Values; Vascular Remodeling; Vascular Resistance | 2016 |
Fibroblast growth factor 23 modifies the pharmacological effects of angiotensin receptor blockade in experimental renal fibrosis.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, Animal; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibrosis; Losartan; Male; Mice; Mice, Inbred C57BL; Receptors, Angiotensin; Renin-Angiotensin System; Tumor Necrosis Factor-alpha; Ureteral Obstruction | 2017 |
Renal denervation significantly attenuates cardiorenal fibrosis in rats with sustained pressure overload.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biomarkers; Cardiomyopathies; Disease Models, Animal; Fibrosis; Heart Atria; Heart Ventricles; Humans; Kidney; Losartan; Myocardium; Natriuretic Peptide, Brain; Peptide Fragments; Procollagen; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Sympathectomy | 2016 |
High potassium promotes mutual interaction between (pro)renin receptor and the local renin-angiotensin-aldosterone system in rat inner medullary collecting duct cells.
Topics: Adrenal Medulla; Aldosterone; Animals; Cytochrome P-450 CYP11B2; Kidney Tubules; Losartan; Male; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Renin; Renin-Angiotensin System | 2016 |
Early treatment with losartan effectively ameliorates hypertension and improves vascular remodeling and function in a prehypertensive rat model.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; Gene Expression Regulation; Hypertension; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Vascular Remodeling | 2017 |
A Novel Aldosterone Antagonist Limits Renal Injury in 5/6 Nephrectomy.
Topics: Albuminuria; Aldosterone; Animals; Blood Pressure; Eplerenone; Losartan; Mineralocorticoid Receptor Antagonists; Nephrectomy; Rats, Wistar; Renal Insufficiency, Chronic; Renin; Treatment Outcome | 2017 |
Cerebrovascular recovery after stroke with individual and combined losartan and captopril treatment of SHRsp.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Cerebrovascular Circulation; Disease Models, Animal; Drug Combinations; Enzyme Activation; Hypertension; Infarction, Middle Cerebral Artery; Losartan; Middle Cerebral Artery; Nitric Oxide; Protein Kinase C; Rats, Inbred SHR; Rats, Inbred WKY; Renin-Angiotensin System; Time Factors; Urea; Uric Acid; Vasoconstriction | 2017 |
Role of the Renin Angiotensin System in Blood Pressure Allostasis-induced by Severe Food Restriction in Female Fischer rats.
Topics: Aldosterone; Allostasis; Angiotensinogen; Angiotensins; Animals; Blood Pressure; Diet; Female; Losartan; Mesenteric Veins; Peptidyl-Dipeptidase A; Phenylephrine; Rats; Rats, Inbred F344; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System | 2018 |
Persistent Renin-Angiotensin System Sensitization Months After Body Weight Recovery From Severe Food Restriction in Female Fischer Rats.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Body Weight; Female; Food Deprivation; Heart Rate; Losartan; Mesenteric Arteries; Peptidyl-Dipeptidase A; Rats, Inbred F344; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Vasoconstriction | 2020 |