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lorazepam glucuronide and lorazepam

lorazepam glucuronide has been researched along with lorazepam in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19904 (28.57)18.7374
1990's2 (14.29)18.2507
2000's7 (50.00)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chaudhary, A; Herman, RJ1
Cummings, AJ; Whitelaw, AG1
Branch, RA; Cotham, R; Desmond, PV; Johnson, R; Porter, J; Schenker, S1
Chiang, ST; Koepke, HH; Morrison, G; Walker, BR1
Greenblatt, DJ; Harmatz, JS; Manis, M; Poorman, R; von Moltke, LL1
Lehmann, N; Müller, C; Svoboda, M; Weinmann, W; Wiedemann, A1
O'Neal, CL; Poklis, A1
Danhof, M; de Jongh, J; Strack van Schijndel, RJ; Swart, EL; Thijs, LG; Zuideveld, KP1
Bertucci, C; da Cunha, SP; da Silva Mathes, Ado C; de Barros Duarte, L; de Carvalho Cavalli, R; Lanchote, VL; Moisés, EC; Papini, O1
Bertucci, C; da Cunha, SP; Dos Santos, NA; Lanchote, VL; Papini, O1
Baldacci, A; Thormann, W1
Goucher, E; Jickells, S; Kicman, A; Smith, N1
De Schepper, PJ; Tjandramaga, TB; Verbeeck, R; Verberckmoes, R1
Bosy, T; Holler, J; Malik-Wolf, B; Vorce, S1

Trials

3 trial(s) available for lorazepam glucuronide and lorazepam

ArticleYear
Kinetic disposition of lorazepam with focus on the glucuronidation capacity, transplacental transfer in parturients and racemization in biological samples.
    Journal of pharmaceutical and biomedical analysis, 2006, Feb-13, Volume: 40, Issue:2

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Chromatography, Liquid; Female; Fetal Blood; Gestational Age; Humans; Lorazepam; Maternal-Fetal Exchange; Parturition; Pregnancy; Spectrometry, Mass, Electrospray Ionization

2006
Quantitative assay of lorazepam and its metabolite glucuronide by reverse-phase liquid chromatography-tandem mass spectrometry in human plasma and urine samples.
    Journal of pharmaceutical and biomedical analysis, 2006, Feb-13, Volume: 40, Issue:2

    Topics: Acetonitriles; Anti-Anxiety Agents; Chromatography, Liquid; Drug Stability; Female; Humans; Lorazepam; Parturition; Pregnancy; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization

2006
Biotransformation and excretion of lorazepam in patients with chronic renal failure.
    British journal of clinical pharmacology, 1976, Volume: 3, Issue:6

    Topics: Adult; Anti-Anxiety Agents; Biotransformation; Humans; Kidney Failure, Chronic; Lorazepam; Male; Renal Dialysis; Young Adult

1976

Other Studies

11 other study(ies) available for lorazepam glucuronide and lorazepam

ArticleYear
In vitro binding of lorazepam and lorazepam glucuronide to cholestyramine, colestipol, and activated charcoal.
    Pharmaceutical research, 1991, Volume: 8, Issue:4

    Topics: Adsorption; Charcoal; Cholestyramine Resin; Colestipol; Kinetics; Lorazepam

1991
A study of conjugation and drug elimination in the human neonate.
    British journal of clinical pharmacology, 1981, Volume: 12, Issue:4

    Topics: Anti-Anxiety Agents; Female; Humans; Hypertension; Infant, Newborn; Lorazepam; Male; Maternal-Fetal Exchange; Methyldopa; Pregnancy; Pregnancy Complications, Cardiovascular; Sulfates

1981
Periportal localization of lorazepam glucuronidation in the isolated perfused rat liver.
    The Journal of laboratory and clinical medicine, 1983, Volume: 102, Issue:5

    Topics: Allyl Compounds; Animals; Carbon Tetrachloride; Kinetics; Liver; Lorazepam; Perfusion; Portal Vein; Rats; Rats, Inbred Strains

1983
Effect of renal impairment and hemodialysis on lorazepam kinetics.
    Clinical pharmacology and therapeutics, 1984, Volume: 35, Issue:5

    Topics: Administration, Oral; Adult; Aged; Biotransformation; Feces; Glomerular Filtration Rate; Humans; Injections, Intravenous; Kidney Diseases; Kinetics; Lorazepam; Middle Aged; Renal Dialysis

1984
Inhibition of acetaminophen and lorazepam glucuronidation in vitro by probenecid.
    Biopharmaceutics & drug disposition, 1993, Volume: 14, Issue:2

    Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Drug Interactions; Female; Humans; In Vitro Techniques; Lorazepam; Macaca; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Probenecid; Rats; Rats, Sprague-Dawley

1993
Identification of lorazepam and sildenafil as examples for the application of LC/ionspray-MS and MS-MS with mass spectra library searching in forensic toxicology.
    Forensic science international, 2000, Sep-11, Volume: 113, Issue:1-3

    Topics: Databases, Factual; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Humans; Lorazepam; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Spectrometry, Mass, Secondary Ion; Substance Abuse Detection; Sulfones; Toxicology

2000
Commentary on: Dou C, Bournique J, Zinda M, Gnezda M, Nally A, Salamone S. Comparison of rates of hydrolysis of lorazepam-glucuronide, oxazepam-glucuronide and temazepam-glucuronide catalyzed by E. coli beta-glucuronidase using the on-line benzodiazepine
    Journal of forensic sciences, 2002, Volume: 47, Issue:2

    Topics: Benzodiazepines; Escherichia coli; Glucuronidase; Humans; Hydrolysis; Immunoassay; Lorazepam; Oxazepam; Temazepam

2002
Population pharmacokinetics of lorazepam and midazolam and their metabolites in intensive care patients on continuous venovenous hemofiltration.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 45, Issue:2

    Topics: Acute Kidney Injury; Adult; Aged; Conscious Sedation; Drug Administration Schedule; Drug Evaluation; Female; Hemofiltration; Humans; Lorazepam; Male; Metabolic Clearance Rate; Midazolam; Middle Aged; Models, Theoretical; Multiple Organ Failure; Respiration, Artificial; Ventilators, Mechanical

2005
Analysis of lorazepam and its 30-glucuronide in human urine by capillary electrophoresis: evidence for the formation of two distinct diastereoisomeric glucuronides.
    Journal of separation science, 2006, Volume: 29, Issue:1

    Topics: Electrophoresis, Capillary; Humans; Lorazepam; Mass Spectrometry; Stereoisomerism

2006
The detection and quantification of lorazepam and its 3-O-glucuronide in fingerprint deposits by LC-MS/MS.
    Journal of separation science, 2009, Volume: 32, Issue:13

    Topics: Adult; Anti-Anxiety Agents; Chromatography, Liquid; Creatinine; Dermatoglyphics; Female; Humans; Lorazepam; Male; Molecular Structure; Skin; Tandem Mass Spectrometry; Young Adult

2009
Evaluation of abalone β-glucuronidase substitution in current urine hydrolysis procedures.
    Journal of analytical toxicology, 2014, Volume: 38, Issue:3

    Topics: Analgesics, Opioid; Animals; Benzodiazepines; Cannabinoids; Codeine; Cost-Benefit Analysis; Escherichia coli; Gastropoda; Glucuronidase; Helix, Snails; Hydrolysis; Lorazepam; Morphine Derivatives; Oxazepam; Specimen Handling; Urinalysis

2014