lorazepam has been researched along with propylene glycol in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.90) | 18.2507 |
| 2000's | 21 (72.41) | 29.6817 |
| 2010's | 6 (20.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Walker, PC; Woycik, CL | 1 |
| Arbour, RB | 1 |
| Cottingham, C; Habashi, NM; McCunn, M; Regan, ME; Reynolds, HN; Scalea, TM; Teiken, P | 1 |
| Arbour, R; Esparis, B | 1 |
| Fraser, GL; Parker, MG; Riker, RR; Watson, DM | 1 |
| Al-Khafaji, AH; Dewhirst, WE; Manning, HL | 1 |
| Barnes, BJ; Mullins, ME | 1 |
| Bencsath, FA; Boerth, R; Chicella, M; Jansen, P; Krueger, KP; Marlowe, KF; Parthiban, A | 1 |
| Nicholson, WJ; Schiffman, F; Tuohy, KA | 1 |
| Arbour, R | 1 |
| Fish, JT; Smith, HW; Wells, JA; Yaucher, NE | 1 |
| Daly, TM; Hardy, R; Hilliard, NJ; Robinson, CA | 1 |
| Arroliga, AC; Gonzales, JP; McCarthy, K; Shehab, N | 1 |
| Jacobi, J | 1 |
| Bouchard, NC; Fulton, JA; Hoffman, RS | 1 |
| Mesler, EL; Neale, BW; Rebuck, JA; Weise, WJ; Young, M | 1 |
| Barnes, BJ; Gerst, C; Mullins, ME; Smith, JR; Terrell, AR | 1 |
| Graeber, C; Sullivan, A; Yusufzai, I; Zar, T | 1 |
| Parmar, MS | 1 |
| Tsai, WC; Tsao, YT; Yang, SP | 1 |
| Fraser, GL; Riker, RR; Subak-Sharpe, S; Yahwak, JA | 1 |
| Bolton, PJ; Hayner, CE; Wuestefeld, NL | 1 |
| Fish, DN; Horinek, EL; Kiser, TH; MacLaren, R | 1 |
| Chau, T; Cheng, CJ; Lin, SH; Yan, MT | 1 |
| Crook, MA; Fung, EC | 1 |
| Stone, RW; Su, Z; Zhu, Y | 1 |
| Boulle-Geronimi, C; Lavoisier, J; Mégarbane, B | 1 |
| Eckhardt, M; Hanff, LM; Koch, BC; Postma, DJ; Smeets, OS; van der Velde, I; van der Vossen, AC; Vermes, A; Vulto, AG | 1 |
| Bodreau, C; Elbarbry, F; Farthing, K; Jahn, A | 1 |
1 trial(s) available for lorazepam and propylene glycol
| Article | Year |
|---|---|
Relationship of continuous infusion lorazepam to serum propylene glycol concentration in critically ill adults.
Topics: Acid-Base Equilibrium; Acidosis; Adult; Critical Illness; Dose-Response Relationship, Drug; Female; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Lorazepam; Male; Middle Aged; Osmolar Concentration; Propylene Glycol; Prospective Studies; Solvents | 2004 |
28 other study(ies) available for lorazepam and propylene glycol
| Article | Year |
|---|---|
Correction and comment: possible toxicity from propylene glycol in injectable drug preparations.
Topics: Chemistry, Pharmaceutical; Child; Humans; Lorazepam; Pentobarbital; Pharmaceutical Vehicles; Propylene Glycol | 1997 |
Propylene glycol toxicity related to high-dose lorazepam infusion: case report and discussion.
Topics: Acidosis; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Lorazepam; Male; Metabolic Clearance Rate; Middle Aged; Pharmaceutical Vehicles; Propylene Glycol; Ventilator Weaning | 1999 |
Hyperlactatemia, increased osmolar gap, and renal dysfunction during continuous lorazepam infusion.
Topics: Adult; Bicarbonates; Conscious Sedation; Humans; Infusions, Intravenous; Kidney Tubules; Lactic Acid; Lorazepam; Male; Myocardial Infarction; Pharmaceutical Vehicles; Propylene Glycol; Respiration, Artificial; Water-Electrolyte Balance | 2000 |
Osmolar gap metabolic acidosis in a 60-year-old man treated for hypoxemic respiratory failure.
Topics: Acidosis, Lactic; Drug Combinations; Humans; Hypnotics and Sedatives; Hypoxia; Infusions, Intravenous; Lactic Acid; Lorazepam; Male; Middle Aged; Osmolar Concentration; Oxygen Inhalation Therapy; Positive-Pressure Respiration; Propylene Glycol; Pyruvic Acid; Respiratory Insufficiency; Solvents | 2000 |
Removal of propylene glycol and correction of increased osmolar gap by hemodialysis in a patient on high dose lorazepam infusion therapy.
Topics: Acidosis, Lactic; Adult; Female; Humans; Infusions, Intravenous; Lorazepam; Osmolar Concentration; Propylene Glycol; Renal Dialysis; Solvents | 2002 |
Propylene glycol toxicity associated with lorazepam infusion in a patient receiving continuous veno-venous hemofiltration with dialysis.
Topics: Adult; Fatal Outcome; GABA Modulators; Hemofiltration; Humans; Kidney Transplantation; Lorazepam; Male; Molecular Weight; Multiple Organ Failure; Pancreatitis; Propylene Glycol; Renal Dialysis; Solvents | 2002 |
Hyperosmolar metabolic acidosis and intravenous Lorazepam.
Topics: Acidosis; Humans; Infusions, Intravenous; Lorazepam; Osmolar Concentration; Pharmaceutical Vehicles; Polyethylene Glycols; Propylene Glycol | 2002 |
Propylene glycol accumulation associated with continuous infusion of lorazepam in pediatric intensive care patients.
Topics: Analysis of Variance; Female; Humans; Hypnotics and Sedatives; Infant; Infusions, Intravenous; Lactic Acid; Lorazepam; Male; Osmolar Concentration; Propylene Glycol | 2002 |
Agitation by sedation.
Topics: Alcoholism; Antidotes; Chemistry, Pharmaceutical; Ethylene Glycol; Female; Fomepizole; Humans; Hypnotics and Sedatives; Lorazepam; Middle Aged; Propylene Glycol; Psychomotor Agitation; Pyrazoles | 2003 |
Propylene glycol toxicity occurs during low-dose infusions of lorazepam.
Topics: Humans; Hypnotics and Sedatives; Infusions, Intravenous; Lorazepam; Propylene Glycol | 2003 |
Propylene glycol-associated renal toxicity from lorazepam infusion.
Topics: Adult; Aged; Biomarkers; Conscious Sedation; Creatinine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Kidney; Lorazepam; Male; Middle Aged; Osmolar Concentration; Propylene Glycol; Retrospective Studies | 2003 |
Pathologic quiz case: repeated positive ethylene glycol levels by gas chromatography. Central venous line contamination of blood samples by propylene glycol from intravenous lorazepam injections.
Topics: Adult; Alcohol Withdrawal Delirium; Catheterization, Central Venous; Chromatography, Gas; Ethylene Glycol; False Positive Reactions; Humans; Injections, Intravenous; Lorazepam; Male; Poisoning; Preservatives, Pharmaceutical; Propylene Glycol; Renal Dialysis | 2004 |
Medication vehicle injury--using the proper restraint?
Topics: Critical Illness; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy, Combination; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Lorazepam; Osmolar Concentration; Propylene Glycol; Solvents | 2004 |
Propylene glycol accumulation after high-dose lorazepam: what have we learned?
Topics: Acid-Base Equilibrium; Acidosis; Critical Illness; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Lorazepam; Propylene Glycol | 2005 |
Propylene glycol-induced lactic acidosis in a patient with normal renal function: a proposed mechanism and monitoring recommendations.
Topics: Acidosis, Lactic; Adult; Drug Carriers; Fatal Outcome; Female; Humans; Hypnotics and Sedatives; Kidney Function Tests; Lorazepam; Monitoring, Physiologic; Propylene Glycol | 2005 |
Osmol gap as a surrogate marker for serum propylene glycol concentrations in patients receiving lorazepam for sedation.
Topics: Adolescent; Adult; Aged; Critical Care; Female; Gas Chromatography-Mass Spectrometry; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Lactic Acid; Linear Models; Lorazepam; Male; Middle Aged; Osmolar Concentration; Pharmaceutical Solutions; Propylene Glycol; Respiration, Artificial; Solvents | 2006 |
Acute kidney injury, hyperosmolality and metabolic acidosis associated with lorazepam.
Topics: Acidosis; Acute Kidney Injury; Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Drug Compounding; Humans; Infusions, Intravenous; Lorazepam; Male; Middle Aged; Osmolar Concentration; Pharmaceutical Vehicles; Propylene Glycol; Renal Dialysis | 2007 |
Re: Acute kidney injury, hyperosmolality and metabolic acidosis associated with lorazepam.
Topics: Acidosis; Acute Kidney Injury; Anti-Anxiety Agents; Drug Compounding; Humans; Lorazepam; Osmolar Concentration; Pharmaceutical Vehicles; Propylene Glycol | 2007 |
A life-threatening double gap metabolic acidosis.
Topics: Acidosis; Alcoholism; Diagnosis, Differential; Humans; Hypnotics and Sedatives; Lorazepam; Male; Middle Aged; Propylene Glycol; Renal Dialysis | 2008 |
Determination of a lorazepam dose threshold for using the osmol gap to monitor for propylene glycol toxicity.
Topics: Acid-Base Equilibrium; Adult; Aged; Creatinine; Female; Humans; Hypnotics and Sedatives; Lorazepam; Male; Middle Aged; Osmolar Concentration; Propylene Glycol; Prospective Studies; ROC Curve | 2008 |
Phenobarbital treatment in a patient with resistant alcohol withdrawal syndrome.
Topics: Adult; Alcohol Withdrawal Delirium; Dose-Response Relationship, Drug; Drug Resistance; Humans; Hypnotics and Sedatives; Lorazepam; Male; Pharmaceutical Vehicles; Phenobarbital; Propylene Glycol; Treatment Outcome | 2009 |
Propylene glycol accumulation in critically ill patients receiving continuous intravenous lorazepam infusions.
Topics: Adult; Age Factors; Aged; Critical Illness; Dose-Response Relationship, Drug; Female; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Intensive Care Units; Kidney Diseases; Lorazepam; Male; Middle Aged; Multivariate Analysis; Pharmaceutical Vehicles; Propylene Glycol; Regression Analysis; Retrospective Studies; Risk Factors; Sex Factors | 2009 |
Hunting down a double gap metabolic acidosis.
Topics: Acidosis; Aged; Alcoholism; Fatal Outcome; Female; Humans; Kidney Failure, Chronic; Lorazepam; Pneumonia, Ventilator-Associated; Propylene Glycol; Renal Dialysis | 2010 |
Closing in on the gaps.
Topics: Acidosis; Aged; Alcoholism; Female; Humans; Kidney Failure, Chronic; Lorazepam; Pneumonia, Ventilator-Associated; Propylene Glycol; Renal Dialysis | 2010 |
Positive propylene glycol result in a patient with ethylene glycol poisoning.
Topics: Anticonvulsants; Ethylene Glycol; Humans; Lorazepam; Male; Middle Aged; Pharmaceutical Vehicles; Phenytoin; Propylene Glycol; Solvents | 2014 |
Fatality associated with propylene glycol poisoning in a cirrhotic patient.
Topics: Alanine Transaminase; Epinephrine; Fatal Outcome; Fomepizole; Humans; Liver Cirrhosis; Lorazepam; Male; Middle Aged; Norepinephrine; Propylene Glycol; Pyrazoles; Sodium Bicarbonate | 2016 |
Formulating a poorly water soluble drug into an oral solution suitable for paediatric patients; lorazepam as a model drug.
Topics: Administration, Oral; Adult; Drug Stability; Flavoring Agents; Glycerol; Humans; Lorazepam; Pediatrics; Polyethylene Glycols; Propylene Glycol; Solubility; Solutions; Water | 2017 |
Assessing Propylene Glycol Toxicity in Alcohol Withdrawal Patients Receiving Intravenous Benzodiazepines: A One-Compartment Pharmacokinetic Model.
Topics: Acid-Base Equilibrium; Acidosis; Alcoholism; Benzodiazepines; Diazepam; Female; Humans; Injections, Intravenous; Lorazepam; Male; Middle Aged; Models, Biological; Propylene Glycol; Renal Insufficiency; Retrospective Studies; Substance Withdrawal Syndrome | 2018 |