lorazepam and flumazenil

lorazepam has been researched along with flumazenil in 93 studies

Research

Studies (93)

Timeframe	Studies, this research(%)	All Research%
pre-1990	36 (38.71)	18.7374
1990's	31 (33.33)	18.2507
2000's	20 (21.51)	29.6817
2010's	6 (6.45)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bailey, J; Glue, P; Hudson, A; Nutt, DJ; Wilson, S	1
Byrnes, JJ; Galpern, WR; Greenblatt, DJ; Miller, LG; Shader, RI	1
Miller, LG	1
Galpern, WR; Greenblatt, DJ; Lumpkin, M; Miller, LG; Shader, RI	1
Galpern, WR; Greenblatt, DJ; Miller, LG; Shader, RI	1
Doenicke, A; Greim, M; Juhl, G; Rampf, U; Suttmann, H	1
Morse, WH; Teeple, ES; Wettstein, JG	2
Kadiwar, RM; Pillay, R	1
Wettstein, JG	3
Lopez, A; Rebollo, J	1
Greenblatt, DJ; Miller, LG; Roy, RB; Shader, RI; Summer, WR	1
Broks, P; Preston, GC; Stahl, SM; Traub, M; Ward, CE	1
Chauvin, M; Costes, H; Duvaldestin, P; Guirimand, F; Lebrault, C	1
Hellevuo, K; Kiianmaa, K; Korpi, ER	1
Klotz, U	1
Dunton, AW; Hendler, J; McGrath, J; Pitman, V; Schwam, E; Siegel, J	1
File, SE	2
Ator, NA; Griffiths, RR	2
Johanson, CE; Schuster, CR	1
Ackenheil, M; Doenicke, A; Dorow, R; Duka, T; Noderer, J	1
Spealman, RD; Wettstein, JG	2
Berenberg, D; Dorow, R; Duka, T; Sauerbrey, N	1
Benkert, O; Heuser, I; Wetzel, H	2
File, SE; Lister, RG	1
Lister, RG; Nutt, DJ	1
Greenblatt, DJ; Miller, LG; Paul, SM; Shader, RI	1
Jensen, LH; Petersen, EN	2
Deutsch, SI; Greenblatt, DJ; Miller, LG; Paul, SM; Shader, RI; Thompson, ML	1
Gwee, MC; Wong, PT; Yoong, YL	1
Dingemanse, J; File, SE; Friedman, HL; Greenblatt, DJ	1
File, SE; Wilks, LJ	1
Costello, MJ; Nutt, DJ	1
Doenicke, A; Dorow, R; Duka, T; Klotz, U	1
Bryere, P; Kaijima, M; Naquet, R; Valin, A	1
De Bonnel, G; De Montigny, C	1
Cepeda, C; Comar, D; Crouzel, M; Guibert, B; Hantraye, P; Kaijima, M; Maziere, M; Naquet, R; Prenant, C; Sastre, J	1
Griffiths, RR; Lamb, RJ	1
Bonetti, EP; Cumin, R; Haefely, WE; Scherschlicht, R	1
Andreason, P; Carson, RE; Cohen, R; Greenblatt, DJ; Herscovitch, P; Johanson, CE; King, C; Matthew, E; Paul, SM; Pettigrew, K	1
Clark, RF; Manoguerra, AS; Sage, TA; Tunget, C	1
Burr, G; Fowler, JS; Hitzemann, R; Lowrimore, P; Overall, J; Pappas, N; Pascani, K; Volkow, ND; Wang, GJ; Wolf, AP	1
Hanania, MM	1
Byrnes, JJ; Greenblatt, DJ; Miller, LG; Shader, RI	1
Burke, TF; Miller, LG; Moerschbaecher, JM	1
Bailine, SH; Bernstein, S; Safferman, A; Vital-Herne, J	1
Ator, NA; Griffiths, RR; Sannerud, CA	1
McLachlan, RS; Sharpe, MD; Sprenger, H	1
Klarlund, R; Metzger, E	1
Finder, RL; Moore, PA	1
al-Tikriti, MS; Baldwin, RM; Bradberry, C; Bremner, JD; During, M; Malison, RT; Seibyl, JP; Sybirska, E; Zea-Ponce, Y; Zoghbi, S	1
Evans, SM; Furman, WR; Griffiths, RR; Guarino, JJ; Liebson, I; Roache, JD; Schwam, EM	1
Bishop, KI; Curran, HV	2
Avanzini, P; Caccavari, R; Chittolini, B; Delsignore, R; Fertonani, G; Gerra, G; Giucasto, G; Zaimovic, A	1
de Zeeuw, RA; Ensing, K; Janssen, MJ; Stegeman, M	1
Bhattacharya, SK; Chakrabarti, A; Glover, V; Sandler, M	1
Larson, JS; Lunn, JJ	1
Roach, JT; Sufka, KJ; Watson, GS	1
Benz, A; Covey, DF; Eisenman, LN; Fields, C; Fu, T; He, Y; Mathews, J; Mennerick, S; Steinbach, JH; Wang, M; Zeng, CM; Zorumski, CF; Zorumski, E	1
Agelink, MW; Andrich, J; Majewski, TB; Mueck-Weymann, M	1
Gong, QH; Gulinello, M; Smith, SS	1
Carter, AR; Cheo-Isaacs, CT; Crooke, JJ; DeLuca, S; DeVine, A; Dubinsky, B; Hochman, C; Jordan, AD; Reitz, AB; Rosenthal, DI; Shank, RP; Vaidya, AH	1
Gulinello, M; Smith, SS	1
Flanigan, J; Olshaker, JS	1
Bisbrown-Chippendale, R; Bullmore, ET; Dirckx, SG; Kerwin, RW; McKenna, PJ; Ooi, C; Pickard, JD; Stephenson, CM; Suckling, J	1
Feeney, A; Grasby, PG; Lingford-Hughes, A; Nutt, DJ; Wilson, SJ	1
Atack, JR; Cook, SM; McKernan, RM; Pym, LJ; Rosahl, T	1
Kazis, A; Kazis, DA; Kimiskidis, VK; Mills, KR; Papagiannopoulos, S; Sotirakoglou, K; Vasiliadis, G; Zara, F	1
Aigbirhio, FI; Atack, JR; Baron, JC; Beech, JS; Clark, JC; Cleij, MC; Fryer, TD; Hargreaves, RJ; Hughes, JL; Scott-Stevens, P	1
France, CP; Javors, MA; McMahon, LR	1
Bullmore, E; Fletcher, P; Kamath, S; McKenna, P; Menzies, L; Ooi, C; Stephenson, C; Suckling, J	1
Gutman, DA; Nemeroff, CB; Owens, MJ; Skelton, KH; Thrivikraman, KV	1
Ahonen, J; Olkkola, KT	1
Darbra, S; Pallarès, M	1
Furst, BA; Kwon, GE; Makhinson, M; Shuff, MK	1
Reti, IM; Wachtel, LE; Ying, H	1
Djordjević, S; Ercegović, GV; Segrt, Z; Stosić, JJ; Vukcević, NP	1
Bailey, AM; Baum, RA; Horn, K; Justice, SN; Lewis, T; Morizio, K; Schultz, A; Weant, K	1

Reviews

9 review(s) available for lorazepam and flumazenil

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Chronic benzodiazepine administration: from the patient to the gene. Journal of clinical pharmacology, 1991, Volume: 31, Issue:6 Topics: Alprazolam; Animals; Benzodiazepines; Clonazepam; Down-Regulation; Drug Tolerance; Flumazenil; Humans; Lorazepam; Mice; Receptors, GABA-A; RNA, Messenger; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors; Up-Regulation	1991
Flumazenil: US clinical pharmacology studies. European journal of anaesthesiology. Supplement, 1988, Volume: 2 Topics: Adult; Diazepam; Double-Blind Method; Drug Interactions; Female; Flumazenil; Humans; Lorazepam; Male; Memory; Receptors, GABA-A; Triazolam	1988
What can be learned from the effects of benzodiazepines on exploratory behavior? Neuroscience and biobehavioral reviews, 1985,Spring, Volume: 9, Issue:1 Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Carbolines; Environment; Exploratory Behavior; Flumazenil; Lorazepam; Mice; Motor Activity; Pyrazoles; Rats; Receptors, GABA-A	1985
Delayed onset lorazepam poisoning successfully reversed by flumazenil in a child. Case report and review of the literature. Pediatric emergency care, 1995, Volume: 11, Issue:1 Topics: Child, Preschool; Female; Flumazenil; Humans; Lorazepam; Poisoning; Sleep Stages; Time Factors	1995
Benzodiazepines for intravenous conscious sedation: agonists and antagonists. Compendium (Newtown, Pa.), 1993, Volume: 14, Issue:8 Topics: Anesthesia, Dental; Benzodiazepines; Conscious Sedation; Diazepam; Flumazenil; Humans; Injections, Intravenous; Lorazepam; Midazolam	1993
Comparing drugs for short-term sedation. Contemporary internal medicine, 1994, Volume: 6, Issue:12 Topics: Anesthesia; Benzodiazepines; Conscious Sedation; Diazepam; Flumazenil; Humans; Lorazepam; Midazolam; Pain; Propofol	1994
Midazolam and other benzodiazepines. Handbook of experimental pharmacology, 2008, Issue:182 Topics: Anesthetics, Intravenous; Animals; Benzodiazepines; Biotransformation; Central Nervous System; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Humans; Lorazepam; Midazolam; Molecular Structure; Receptors, GABA-A; Structure-Activity Relationship	2008
Review of Intranasally Administered Medications for Use in the Emergency Department. The Journal of emergency medicine, 2017, Volume: 53, Issue:1 Topics: Administration, Intranasal; Anesthetics, Dissociative; Anticonvulsants; Antidotes; Antipsychotic Agents; Dexmedetomidine; Emergency Service, Hospital; Fentanyl; Flumazenil; Haloperidol; Humans; Hydromorphone; Hypnotics and Sedatives; Ketamine; Lorazepam; Midazolam; Naloxone; Narcotic Antagonists; Narcotics	2017

Trials

15 trial(s) available for lorazepam and flumazenil

Article	Year
Thyrotropin-releasing hormone selectively reverses lorazepam-induced sedation but not slowing of saccadic eye movements. Life sciences, 1992, Volume: 50, Issue:6 Topics: Adult; Conscious Sedation; Female; Flumazenil; Flunitrazepam; Humans; Injections, Intravenous; Kinetics; Lorazepam; Male; Radioligand Assay; Receptors, GABA-A; Saccades; Sleep Stages; Thyrotropin-Releasing Hormone	1992
[Beta activation following the intravenous administration of benzodiazepines and the specific antagonist flumazenil (Ro 15-1788)]. EEG-EMG Zeitschrift fur Elektroenzephalographie, Elektromyographie und verwandte Gebiete, 1990, Volume: 21, Issue:1 Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Beta Rhythm; Diazepam; Dose-Response Relationship, Drug; Electroencephalography; Flumazenil; Flunitrazepam; Humans; Injections, Intravenous; Lorazepam; Male; Midazolam; Prospective Studies; Randomized Controlled Trials as Topic; Stimulation, Chemical	1990
Effects of lorazepam on memory, attention and sedation in man: antagonism by Ro 15-1788. Psychopharmacology, 1989, Volume: 97, Issue:2 Topics: Adolescent; Adult; Attention; Female; Flicker Fusion; Flumazenil; Humans; Hypnotics and Sedatives; Lorazepam; Male; Memory; Psychomotor Performance; Reaction Time; Visual Acuity	1989
Flumazenil: US clinical pharmacology studies. European journal of anaesthesiology. Supplement, 1988, Volume: 2 Topics: Adult; Diazepam; Double-Blind Method; Drug Interactions; Female; Flumazenil; Humans; Lorazepam; Male; Memory; Receptors, GABA-A; Triazolam	1988
Changes in noradrenaline plasma levels and behavioural responses induced by benzodiazepine agonists with the benzodiazepine antagonist Ro 15-1788. Psychopharmacology, 1986, Volume: 90, Issue:3 Topics: Adult; Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Blood Pressure; Double-Blind Method; Electrocardiography; Electroencephalography; Flumazenil; Flunitrazepam; Humans; Lorazepam; Male; Norepinephrine; Random Allocation	1986
Amnestic effects of lormetazepam and their reversal by the benzodiazepine antagonist Ro 15-1788. Psychopharmacology, 1987, Volume: 93, Issue:4 Topics: Adult; Amnesia; Anti-Anxiety Agents; Benzodiazepines; Cognition; Emotions; Female; Flumazenil; Humans; Lorazepam; Male; Memory	1987
Flunitrazepam and lormetazepam do not affect the pharmacokinetics of the benzodiazepine antagonist Ro 15-1788. British journal of clinical pharmacology, 1985, Volume: 19, Issue:1 Topics: Adolescent; Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Flumazenil; Flunitrazepam; Humans; Kinetics; Lorazepam; Male	1985
Intravenous flumazenil following acute and repeated exposure to lorazepam in healthy volunteers: antagonism and precipitated withdrawal. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:3 Topics: Adolescent; Adult; Drug Interactions; Flumazenil; Hemodynamics; Humans; Injections, Intravenous; Lorazepam; Male; Middle Aged; Reference Values; Respiration; Substance Withdrawal Syndrome	1993
Psychopharmacological analysis of implicit and explicit memory: a study with lorazepam and the benzodiazepine antagonist flumazenil. Psychopharmacology, 1995, Volume: 121, Issue:2 Topics: Adolescent; Adult; Attention; Female; Flumazenil; Humans; Lorazepam; Male; Memory; Mental Recall; Middle Aged; Placebo Effect; Receptors, GABA-A; Task Performance and Analysis	1995
Intravenous flumazenil following prolonged exposure to lormetazepam in humans: lack of precipitated withdrawal. International clinical psychopharmacology, 1996, Volume: 11, Issue:2 Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Double-Blind Method; Flumazenil; GABA Modulators; Humans; Injections, Intravenous; Lorazepam; Male; Substance Withdrawal Syndrome	1996
An investigation of the effects of benzodiazepine receptor ligands and of scopolamine on conceptual priming. Psychopharmacology, 1998, Volume: 140, Issue:3 Topics: Adolescent; Adult; Female; Flumazenil; GABA Modulators; Humans; Lorazepam; Male; Memory; Middle Aged; Muscarinic Antagonists; Neuropsychological Tests; Scopolamine	1998
Short-term effects of intravenous benzodiazepines on autonomic neurocardiac regulation in humans: a comparison between midazolam, diazepam, and lorazepam. Critical care medicine, 2002, Volume: 30, Issue:5 Topics: Adult; Autonomic Nervous System; Benzodiazepines; Diazepam; Female; Flumazenil; Heart; Heart Rate; Humans; Injections, Intravenous; Lorazepam; Male; Midazolam; Middle Aged; Preanesthetic Medication; Prospective Studies	2002
GABAergic inhibitory mechanisms for repetition-adaptivity in large-scale brain systems. NeuroImage, 2003, Volume: 19, Issue:4 Topics: Adult; Arousal; Brain Mapping; Cerebral Cortex; Double-Blind Method; Female; Flumazenil; GABA Agonists; gamma-Aminobutyric Acid; Habituation, Psychophysiologic; Humans; Image Enhancement; Image Processing, Computer-Assisted; Lorazepam; Magnetic Resonance Imaging; Male; Memory, Short-Term; Middle Aged; Neural Inhibition	2003
A proof-of-concept study using [11C]flumazenil PET to demonstrate that pagoclone is a partial agonist. Psychopharmacology, 2005, Volume: 180, Issue:4 Topics: Area Under Curve; Brain; Carbon Isotopes; Drug Interactions; Flumazenil; GABA Modulators; Humans; Isoindoles; Lorazepam; Male; Naphthyridines; Positron-Emission Tomography	2005
Effects of gamma-aminobutyric acid-modulating drugs on working memory and brain function in patients with schizophrenia. Archives of general psychiatry, 2007, Volume: 64, Issue:2 Topics: Adult; Brain; Cerebral Cortex; Cognition Disorders; Double-Blind Method; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Humans; Interneurons; Lorazepam; Magnetic Resonance Imaging; Male; Memory; Middle Aged; Models, Neurological; Neural Pathways; Neuropsychological Tests; Placebos; Schizophrenia; Schizophrenic Psychology; Synaptic Transmission	2007

Other Studies

70 other study(ies) available for lorazepam and flumazenil

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Chronic benzodiazepine administration. X. Concurrent administration of the peripheral-type benzodiazepine ligand PK11195 attenuates chronic effects of lorazepam. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:1 Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Down-Regulation; Flumazenil; Isoquinolines; Ligands; Lorazepam; Male; Mice; Motor Activity; Receptors, GABA-A	1992
Modification of gamma-aminobutyric acidA receptor binding and function by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in vitro and in vivo: effects of aging. Journal of neurochemistry, 1991, Volume: 56, Issue:4 Topics: Aging; Animals; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Cortex; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Kinetics; Lorazepam; Male; Mice; Mice, Inbred Strains; Quinolines; Receptors, GABA-A	1991
Differential effects of chronic lorazepam and alprazolam on benzodiazepine binding and GABAA-receptor function. British journal of pharmacology, 1990, Volume: 101, Issue:4 Topics: Alprazolam; Animals; Benzodiazepines; Brain Chemistry; Flumazenil; Lorazepam; Male; Mice; Receptors, GABA-A	1990
Respiratory effects of benzodiazepine-related drugs in awake rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:3 Topics: Administration, Inhalation; Alprazolam; Animals; Anti-Anxiety Agents; Appetite Depressants; Benzodiazepines; Buspirone; Carbolines; Carbon Dioxide; Drug Therapy, Combination; Female; Flumazenil; Lorazepam; Macaca mulatta; Male; Pentobarbital; Plethysmography; Pyrazoles; Respiration	1990
Flumazenil therapy in benzodiazepine self-poisoning. Irish medical journal, 1991, Volume: 84, Issue:1 Topics: Adult; Diazepam; Female; Flumazenil; Humans; Lorazepam; Middle Aged; Poisoning	1991
Unusual behavioral profile of alprazolam in squirrel monkeys. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 253, Issue:3 Topics: Alprazolam; Animals; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Electroshock; Flumazenil; Injections, Intravenous; Lorazepam; Male; Psychomotor Performance; Saimiri	1990
Benzodiazepine withdrawal syndrome after a benzodiazepine antagonist. Critical care medicine, 1990, Volume: 18, Issue:12 Topics: Adolescent; Akathisia, Drug-Induced; Diazepam; Drug Overdose; Flumazenil; Humans; Injections, Intravenous; Intubation, Gastrointestinal; Lorazepam; Male; Psychomotor Agitation; Substance Withdrawal Syndrome; Therapeutic Irrigation; Thiopental	1990
Chronic benzodiazepine administration. II. Discontinuation syndrome is associated with upregulation of gamma-aminobutyric acidA receptor complex binding and function. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:1 Topics: Animals; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorides; Drug Tolerance; Flumazenil; Flunitrazepam; Ion Channels; Lorazepam; Male; Mice; Motor Activity; Muscimol; Receptors, GABA-A; Time Factors	1988
Behavioral studies with the beta-carboline FG 7142 combined with related drugs in monkeys. European journal of pharmacology, 1989, Apr-25, Volume: 163, Issue:2-3 Topics: Animals; Appetite Depressants; Behavior, Animal; Benzodiazepines; Carbolines; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Lorazepam; Male; Pyrazoles; Reinforcement Schedule; Saimiri	1989
[Antagonism of the effects of midazolam by flumazenil on the consumption of oxygen by the body]. Annales francaises d'anesthesie et de reanimation, 1989, Volume: 8 Suppl Topics: Anesthesia; Flumazenil; Humans; Lorazepam; Midazolam; Oxygen Consumption; Postoperative Period; Preanesthetic Medication	1989
Effect of GABAergic drugs on motor impairment from ethanol, barbital and lorazepam in rat lines selected for differential sensitivity to ethanol. Pharmacology, biochemistry, and behavior, 1989, Volume: 34, Issue:2 Topics: Animals; Barbital; Barbiturates; Dose-Response Relationship, Drug; Ethanol; Female; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Isoniazid; Lorazepam; Picrotoxin; Psychomotor Performance; Rats	1989
Drug interactions and clinical pharmacokinetics of flumazenil. European journal of anaesthesiology. Supplement, 1988, Volume: 2 Topics: Anti-Anxiety Agents; Benzodiazepines; Biological Availability; Drug Interactions; Ethanol; Flumazenil; Flunitrazepam; Half-Life; Humans; Liver; Lorazepam; Midazolam; Receptors, GABA-A; Tomography, Emission-Computed	1988
Discriminative stimulus effects of atypical anxiolytics in baboons and rats. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:2 Topics: Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Benzodiazepinones; Buspirone; Discrimination Learning; Flumazenil; Isoxazoles; Lorazepam; Male; Papio; Piperazines; Pyrazoles; Pyridazines; Pyrimidines; Quinolines; Rats; Rats, Inbred Strains; Receptors, GABA-A	1986
The effects of Ro 15-1788 on anxiolytic self-administration in the rhesus monkey. Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:4 Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Drug Interactions; Female; Flumazenil; Flurazepam; Lorazepam; Macaca mulatta; Male; Pentobarbital; Reinforcement, Psychology; Self Administration	1986
Behavioral effects of the beta-carboline derivatives ZK 93423 and ZK 91296 in squirrel monkeys: comparison with lorazepam and suriclone. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:2 Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Carbolines; Electroshock; Flumazenil; Lorazepam; Male; Naphthyridines; Piperazines; Receptors, GABA-A; Saimiri; Sulfur Compounds	1987
Flumazenil and benzodiazepine withdrawal. Lancet (London, England), 1987, Aug-22, Volume: 2, Issue:8556 Topics: Animals; Anxiety; Benzodiazepines; Flumazenil; Lorazepam; Male; Mice; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substance Withdrawal Syndrome	1987
Effects of the novel benzodiazepine agonist quazepam on suppressed behavior of monkeys. European journal of pharmacology, 1988, Oct-11, Volume: 155, Issue:1-2 Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Conditioning, Operant; Dose-Response Relationship, Drug; Flumazenil; Lorazepam; Male; Quinazolines; Reinforcement Schedule; Saimiri	1988
Benzodiazepines for catatonic symptoms, stupor, and mutism. Pharmacopsychiatry, 1988, Volume: 21, Issue:6 Topics: Anti-Anxiety Agents; Benzodiazepines; Catatonia; Depressive Disorder; Diazepam; Female; Flumazenil; Humans; Lorazepam; Mutism	1988
A late-appearing benzodiazepine-induced hypoactivity that is not reversed by a receptor antagonist. Psychopharmacology, 1986, Volume: 88, Issue:4 Topics: Animals; Benzodiazepinones; Brain; Drug Interactions; Flumazenil; Lorazepam; Male; Motor Activity; Rats; Receptors, GABA-A; Substance Withdrawal Syndrome; Time Factors	1986
Mice and rats are sensitized to the proconvulsant action of a benzodiazepine-receptor inverse agonist (FG 7142) following a single dose of lorazepam. Brain research, 1986, Aug-06, Volume: 379, Issue:2 Topics: Animals; Benzodiazepinones; Carbolines; Convulsants; Drug Interactions; Flumazenil; Injections, Intraperitoneal; Lorazepam; Mice; Rats; Receptors, GABA-A; Species Specificity; Time Factors	1986
Benzodiazepine receptor occupancy in vivo: correlation with brain concentrations and pharmacodynamic actions. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:2 Topics: Animals; Cerebral Cortex; Clonazepam; Dose-Response Relationship, Drug; Flumazenil; Lorazepam; Male; Mice; Receptors, GABA-A; Time Factors	1987
Chronic treatment with lorazepam and FG 7142 may change the effects of benzodiazepine receptor agonists, antagonists and inverse agonists by different mechanisms. European journal of pharmacology, 1987, Jan-20, Volume: 133, Issue:3 Topics: Animals; Carbolines; Drug Interactions; Drug Tolerance; Female; Flumazenil; Lorazepam; Mice; Pentylenetetrazole; Receptors, GABA-A	1987
Rapid increase in brain benzodiazepine receptor binding following defeat stress in mice. Brain research, 1987, Jun-30, Volume: 414, Issue:2 Topics: Adrenalectomy; Animals; Brain; Cerebral Cortex; Clonazepam; Flumazenil; Lorazepam; Male; Mice; Receptors, GABA-A; Species Specificity; Stress, Psychological; Time Factors	1987
Acute tolerance to diazepam induced by benzodiazepines. Clinical and experimental pharmacology & physiology, 1986, Volume: 13, Issue:1 Topics: Animals; Benzodiazepines; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Flumazenil; Lorazepam; Male; Mice; Sleep	1986
Chronic treatment with Ro 15-1788 distinguishes between its benzodiazepine antagonist, agonist and inverse agonist properties. Psychopharmacology, 1986, Volume: 89, Issue:1 Topics: Animals; Behavior, Animal; Benzodiazepinones; Brain Chemistry; Carbolines; Drug Interactions; Drug Tolerance; Exploratory Behavior; Flumazenil; Lorazepam; Male; Rats; Social Behavior	1986
Behavioral effects of the pyrazoloquinoline CGS 9896: agonist and antagonist actions in squirrel monkeys. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:1 Topics: Animals; Azabicyclo Compounds; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Lorazepam; Male; Piperazines; Pyrazoles; Saimiri	1987
Stupor and affective state: alleviation of psychomotor disturbances by lorazepam and recurrence of symptoms after Ro 15-1788. The Journal of nervous and mental disease, 1987, Volume: 175, Issue:4 Topics: Adult; Carbamazepine; Coma; Depressive Disorder; Drug Interactions; Drug Therapy, Combination; Female; Flumazenil; Humans; Lorazepam; Mutism	1987
Does the behavioural activation detected after a single dose of a benzodiazepine reflect a withdrawal response? Life sciences, 1988, Volume: 42, Issue:23 Topics: Animals; Behavior, Animal; Benzodiazepines; Flumazenil; Lorazepam; Male; Mice; Motor Activity; Oxazepam	1988
Rapid induction of lorazepam dependence and reversal with flumazenil. Life sciences, 1988, Volume: 43, Issue:13 Topics: Animals; Carbolines; Flumazenil; Lorazepam; Male; Mice; Mice, Inbred Strains; Seizures; Substance-Related Disorders	1988
Recovery from lorazepam tolerance and the effects of a benzodiazepine antagonist (RO 15-1788) on the development of tolerance. Psychopharmacology, 1982, Volume: 77, Issue:3 Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Drug Tolerance; Exploratory Behavior; Flumazenil; Lorazepam; Male; Motor Activity; Rats	1982
Lorazepam and pentobarbital drug discrimination in baboons: cross-drug generalization and interaction with Ro 15-1788. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:3 Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Generalization, Response; Lorazepam; Male; Papio; Pentobarbital	1983
Differential effects of the benzodiazepine antagonist Ro 15-1788 on two types of myoclonus in baboon Papio papio. Neuroscience letters, 1983, Jul-15, Volume: 38, Issue:1 Topics: 5-Hydroxytryptophan; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepinones; Flumazenil; gamma-Aminobutyric Acid; Light; Lorazepam; Myoclonus; Papio; Seizures	1983
Benzodiazepine selectively antagonize kainate-induced activation in the rat hippocampus. European journal of pharmacology, 1983, Sep-16, Volume: 93, Issue:1-2 Topics: Acetylcholine; Animals; Anti-Anxiety Agents; Benzodiazepinones; Chlorpromazine; Diazepam; Flumazenil; Glutamates; Hippocampus; Injections, Intravenous; Iontophoresis; Kainic Acid; Lorazepam; Male; Phenobarbital; Pyramidal Tracts; Pyrrolidines; Rats; Rats, Inbred Strains	1983
Bidirectional effects of benzodiazepine receptor ligands against picrotoxin- and pentylenetetrazol-induced seizures. Journal of neural transmission, 1983, Volume: 58, Issue:3-4 Topics: Animals; Anticonvulsants; Benzodiazepinones; Brain; Convulsants; Dose-Response Relationship, Drug; Flumazenil; Lorazepam; Male; Muridae; Pentylenetetrazole; Picrotoxin; Receptors, Cell Surface; Receptors, GABA-A; Seizures	1983
[In vivo study of benzodiazepine receptors using positron emission tomography]. L'Encephale, 1983, Volume: 9, Issue:4 Suppl 2 Topics: Animals; Benzodiazepinones; Binding, Competitive; Brain; Chlordiazepoxide; Flumazenil; Flunitrazepam; Kinetics; Lorazepam; Male; Papio; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Neurotransmitter; Stereoisomerism	1983
Precipitated and spontaneous withdrawal in baboons after chronic dosing with lorazepam and CGS 9896. Drug and alcohol dependence, 1984, Volume: 14, Issue:1 Topics: Animals; Benzodiazepinones; Flumazenil; Humans; Lorazepam; Male; Papio; Pyrazoles; Substance Withdrawal Syndrome; Substance-Related Disorders	1984
Use of the specific benzodiazepine antagonist, Ro 15-1788, in studies of physiological dependence on benzodiazepines. Experientia, 1982, Jul-15, Volume: 38, Issue:7 Topics: Animals; Benzodiazepines; Benzodiazepinones; Cats; Diazepam; Female; Flumazenil; Humans; Lorazepam; Male; Mice; Rats; Saimiri; Substance Withdrawal Syndrome; Substance-Related Disorders; Triazolam	1982
Benzodiazepine receptors mediate regional blood flow changes in the living human brain. Proceedings of the National Academy of Sciences of the United States of America, 1995, Mar-28, Volume: 92, Issue:7 Topics: Adult; Affect; Brain; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Flumazenil; Functional Laterality; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; Kinetics; Lorazepam; Male; Organ Specificity; Oxygen Radioisotopes; Receptors, GABA-A; Reference Values; Regional Blood Flow; Time Factors; Tomography, Emission-Computed	1995
Depression of thalamic metabolism by lorazepam is associated with sleepiness. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1995, Volume: 12, Issue:2 Topics: Adult; Cognition; Deoxyglucose; Depression, Chemical; Flumazenil; Fluorodeoxyglucose F18; Glucose; Humans; Lorazepam; Male; Middle Aged; Occipital Lobe; Sleep; Thalamus; Tomography, Emission-Computed	1995
Flumazenil reversal of benzodiazepine sedation before electroconvulsive therapy. Anesthesiology, 1995, Volume: 82, Issue:1 Topics: Adult; Electroconvulsive Therapy; Female; Flumazenil; Humans; Lorazepam; Male	1995
Chronic benzodiazepine administration. XII. Anticonvulsant cross-tolerance but distinct neurochemical effects of alprazolam and lorazepam. Psychopharmacology, 1993, Volume: 111, Issue:1 Topics: Alprazolam; Animals; Anticonvulsants; Brain Chemistry; Cerebral Cortex; Down-Regulation; Drug Tolerance; Flumazenil; Hippocampus; Lorazepam; Male; Mice; Pentylenetetrazole; Receptors, GABA-A; Seizures	1993
Acute effects of benzodiazepines on operant behavior and in vivo receptor binding in mice. Pharmacology, biochemistry, and behavior, 1994, Volume: 48, Issue:1 Topics: Alprazolam; Animals; Anti-Anxiety Agents; Binding, Competitive; Conditioning, Operant; Dose-Response Relationship, Drug; Flumazenil; Lorazepam; Male; Mice; Receptors, GABA-A; Reinforcement Schedule	1994
Flumazenil reversal of benzodiazepine-induced sedation for a patient with severe pre-ECT anxiety. Convulsive therapy, 1994, Volume: 10, Issue:1 Topics: Adult; Anti-Anxiety Agents; Anxiety; Electroconvulsive Therapy; Flumazenil; Humans; Lorazepam; Male; Midazolam; Schizophrenia	1994
Combination of buspirone and other drugs with beta-CCE in monkeys: effects on respiration and behavior. Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:3 Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Buspirone; Carbolines; Carbon Dioxide; Conditioning, Operant; Drug Interactions; Female; Flumazenil; Lorazepam; Macaca mulatta; Male; Pyridazines; Respiration; Respiratory Mechanics; Tidal Volume	1993
Behavioral pharmacology of tandospirone in baboons: chronic administration and withdrawal, self-injection and drug discrimination. Drug and alcohol dependence, 1993, Volume: 32, Issue:3 Topics: Animals; Anti-Anxiety Agents; Arousal; Buspirone; Cocaine; Discrimination Learning; Dose-Response Relationship, Drug; Eating; Flumazenil; Isoindoles; Lorazepam; Male; Motor Skills; Neurologic Examination; Papio; Pentobarbital; Piperazines; Pyrimidines; Reinforcement Schedule; Self Administration; Serotonin Receptor Agonists; Substance Withdrawal Syndrome; Substance-Related Disorders	1993
Flumazenil as a diagnostic tool in the differential diagnosis of coma in a critically ill patient. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:1 Topics: Aged; Bacterial Infections; Coma; Critical Illness; Diagnosis, Differential; Diazepam; Flumazenil; Hepatic Encephalopathy; Humans; Lorazepam; Male; Midazolam	1994
Flumazenil: an antidotal anecdote. The American journal of psychiatry, 1994, Volume: 151, Issue:6 Topics: Aged; Drug Overdose; Female; Flumazenil; Humans; Lorazepam	1994
[123I]iomazenil SPECT imaging demonstrates significant benzodiazepine receptor reserve in human and nonhuman primate brain. Neuropharmacology, 1993, Volume: 32, Issue:7 Topics: Adult; Animals; Binding, Competitive; Brain; Dialysis; Female; Flumazenil; gamma-Aminobutyric Acid; Half-Life; Humans; Hypnotics and Sedatives; Iodine Radioisotopes; Lorazepam; Male; Nipecotic Acids; Ovariectomy; Papio; Receptors, GABA-A; Tiagabine; Tomography, Emission-Computed, Single-Photon	1993
Solubilized benzodiazepine receptors for use in receptor assays. Journal of pharmaceutical and biomedical analysis, 1996, Volume: 14, Issue:8-10 Topics: Adsorption; Animals; Binding, Competitive; Brain; Cattle; Cell Membrane; Charcoal; Filtration; Flumazenil; GABA Modulators; In Vitro Techniques; Lorazepam; Polyethylene Glycols; Protein Binding; Radioligand Assay; Receptors, GABA-A; Solubility; Spectrometry, Fluorescence	1996
Anxiolytic activity of intraventricularly administered atrial natriuretic peptide in the rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1996, Volume: 15, Issue:2 Topics: Animals; Anxiety; Atrial Natriuretic Factor; Behavior, Animal; Drug Interactions; Feeding Behavior; Flumazenil; GABA Modulators; Injections, Intraventricular; Isatin; Lorazepam; Male; Postural Balance; Rats; Rats, Wistar; Social Behavior	1996
Benzodiazepine receptor function in the chick social separation-stress procedure. Experimental and clinical psychopharmacology, 1999, Volume: 7, Issue:2 Topics: Alprazolam; Analgesia; Animals; Anti-Anxiety Agents; Chickens; Chlordiazepoxide; Disease Models, Animal; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Lorazepam; Receptors, GABA-A; Social Behavior; Stress, Psychological	1999
3beta -hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, May-01, Volume: 22, Issue:9 Topics: Amino Acid Substitution; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Flumazenil; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hydroxysteroids; Lorazepam; Oocytes; Patch-Clamp Techniques; Pregnanes; Pregnenolone; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship; Synapses; Xenopus laevis	2002
Progesterone withdrawal increases the alpha4 subunit of the GABA(A) receptor in male rats in association with anxiety and altered pharmacology - a comparison with female rats. Neuropharmacology, 2002, Volume: 43, Issue:4 Topics: Animals; Anxiety; Blotting, Western; Female; Flumazenil; GABA Modulators; Hippocampus; Lorazepam; Male; Membrane Potentials; Motor Activity; Patch-Clamp Techniques; Progesterone; Pyramidal Cells; Rats; Receptors, GABA-A; Sex Characteristics; Substance Withdrawal Syndrome	2002
5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide (RWJ-51204), a new nonbenzodiazepine anxiolytic. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:2 Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Central Nervous System Depressants; Chlordiazepoxide; Conflict, Psychological; Conscious Sedation; Convulsants; Drug Interactions; Ethanol; Flumazenil; GABA Modulators; Imidazoles; Lorazepam; Male; Mice; Motor Activity; Pentylenetetrazole; Postural Balance; Pyridones; Rats; Rats, Long-Evans; Receptors, GABA-A; Saimiri; Seizures	2002
Anxiogenic effects of neurosteroid exposure: sex differences and altered GABAA receptor pharmacology in adult rats. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:2 Topics: Acoustic Stimulation; Aging; Animals; Anti-Anxiety Agents; Anxiety; Exploratory Behavior; Female; Flumazenil; GABA Modulators; Lorazepam; Male; Pregnanolone; Progesterone; Rats; Rats, Long-Evans; Receptors, GABA-A; Reflex, Startle; Sex Characteristics	2003
Flumazenil reversal of lorazepam-induced acute delirium. The Journal of emergency medicine, 2003, Volume: 24, Issue:2 Topics: Anti-Anxiety Agents; Antidotes; Delirium; Flumazenil; Humans; Lorazepam; Male; Middle Aged	2003
Selective labelling of diazepam-insensitive GABAA receptors in vivo using [3H]Ro 15-4513. British journal of pharmacology, 2005, Volume: 146, Issue:6 Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Cerebellum; Flumazenil; Humans; Isotope Labeling; Ligands; Lorazepam; Male; Mice; Mice, Transgenic; Prosencephalon; Receptors, GABA-A; Receptors, GABA-B; Tritium	2005
Lorazepam-induced effects on silent period and corticomotor excitability. Experimental brain research, 2006, Volume: 173, Issue:4 Topics: Adult; Anti-Anxiety Agents; Cerebral Cortex; Evoked Potentials, Motor; Flumazenil; Humans; Infusions, Intravenous; Lorazepam; Male; Motor Activity; Reaction Time	2006
Comparison of lorazepam [7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one] occupancy of rat brain gamma-aminobutyric acid(A) receptors measured using in vivo [3H]flumazenil (8-fluoro 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a] The Journal of pharmacology and experimental therapeutics, 2007, Volume: 320, Issue:3 Topics: Animals; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Flumazenil; Injections, Intravenous; Lorazepam; Male; Positron-Emission Tomography; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A	2007
Changes in relative potency among positive GABA(A) receptor modulators upon discontinuation of chronic benzodiazepine treatment in rhesus monkeys. Psychopharmacology, 2007, Volume: 192, Issue:1 Topics: Animals; Behavior, Animal; Benzodiazepines; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Lorazepam; Macaca mulatta; Male; Midazolam; Pentobarbital; Pregnanediones; Pregnanolone; Receptors, GABA-A; Substance Withdrawal Syndrome	2007
The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal. Psychopharmacology, 2007, Volume: 192, Issue:3 Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Flumazenil; Gene Expression; Hypnotics and Sedatives; Hypothalamo-Hypophyseal System; Lorazepam; Male; Neurons; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; RNA, Heterogeneous Nuclear; Stress, Physiological; Substance Withdrawal Syndrome; Substance-Related Disorders	2007
Neonatal allopregnanolone increases novelty-directed locomotion and disrupts behavioural responses to GABA(A) receptor modulators in adulthood. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2009, Volume: 27, Issue:6 Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Exploratory Behavior; Flumazenil; GABA Modulators; Isoxazoles; Lorazepam; Male; Maze Learning; Midazolam; Motor Activity; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A	2009
Successful treatment of co-occurring catatonia and obsessive-compulsive disorder with concurrent electroconvulsive therapy and benzodiazepine administration. The journal of ECT, 2012, Volume: 28, Issue:3 Topics: Adult; Benzodiazepines; Catatonia; Combined Modality Therapy; Depressive Disorder, Major; Electroconvulsive Therapy; Female; Flumazenil; GABA Modulators; Humans; Lorazepam; Obsessive-Compulsive Disorder	2012
Stability of intraocular pressure after retinal reattachment surgery during electroconvulsive therapy for intractable self-injury in a 12-year-old autistic boy. The journal of ECT, 2014, Volume: 30, Issue:1 Topics: Aggression; Anticonvulsants; Antipsychotic Agents; Autistic Disorder; Child; Electroconvulsive Therapy; Flumazenil; GABA Modulators; Haloperidol; Humans; Hypnotics and Sedatives; Intraocular Pressure; Lorazepam; Male; Ophthalmologic Surgical Procedures; Psychomotor Agitation; Retinal Detachment; Self-Injurious Behavior	2014
Benzodiazepine poisoning in elderly. Vojnosanitetski pregled, 2016, Volume: 73, Issue:3 Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antidotes; Benzodiazepines; Bromazepam; Cohort Studies; Coma; Diazepam; Drug Overdose; Female; Flumazenil; Humans; Incidence; Length of Stay; Lorazepam; Male; Middle Aged; Pneumonia, Aspiration; Respiratory Insufficiency; Retrospective Studies; Serbia; Suicide, Attempted; Young Adult	2016