lorazepam and antipyrine

lorazepam has been researched along with antipyrine in 26 studies

Research

Studies (26)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (30.77)	18.7374
1990's	11 (42.31)	18.2507
2000's	6 (23.08)	29.6817
2010's	1 (3.85)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Coassolo, P; Lavé, T; Schneider, G	1
Abraham, MH; Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
DiPiro, JT; Gaines, MG; Hooker, KD; Sherman, JC; Wynn, JJ	1
Christensen, ML; Crom, WR; Evans, WE; Relling, MV; Rivera, GK	1
Boucher, BA; Fabian, TC; Kuhl, DA; Robertson, JT	1
Awni, WM; Halstenson, CE; St Peter, JV	1
Bachmann, KA; Forney, RB; Jauregui, L; Martin, M; Nunlee, M; Schwartz, J	1
Crom, WR; Evans, WE; Kearns, GL; Mallory, GB	1
Blyden, GT; Greenblatt, DJ; Scavone, JM	1
Awni, WM; Bakker, LJ	1
Crom, WR; Cupit, GC; Evans, WE; Pieper, JA; Relling, MV; Rivera, GK	1
Bobo, L; Crom, WR; Evans, WE; Relling, MV; Teresi, ME; Webster, SL	1
Evans, WE; Riley, CA	1
Abernethy, DR; Eshelman, FN; Greenblatt, DJ; Shader, RI	1
Abernethy, DR; Ameer, B; Divoll, M; Greenblatt, DJ; Shader, RI	1
Bachmann, KA; Jauregui, L	1
Crom, WR; Evans, WE; Karlson, KH; Kearns, GL; Mallory, GB	1
Bhargava, R; Crom, WR; Evans, WE; Murry, DJ; Reddick, WE	1
Adams, MH; Ferry, JJ; Garnett, WR; Karnes, HT; Poynor, WJ; Ryan, KK; Sarkar, MA	1
Allen, MD; Greenblatt, DJ; Harmatz, JS; Huffman, DH; MacLaughlin, DS; Shader, RI	1

Trials

3 trial(s) available for lorazepam and antipyrine

Article	Year
Ranitidine does not impair oxidative or conjugative metabolism: noninteraction with antipyrine, diazepam, and lorazepam. Clinical pharmacology and therapeutics, 1984, Volume: 35, Issue:2 Topics: Adult; Antipyrine; Biotransformation; Diazepam; Drug Interactions; Humans; Kinetics; Lorazepam; Male; Middle Aged; Random Allocation; Ranitidine	1984
Use of single sample clearance estimates of cytochrome P450 substrates to characterize human hepatic CYP status in vivo. Xenobiotica; the fate of foreign compounds in biological systems, 1993, Volume: 23, Issue:3 Topics: Administration, Oral; Adult; Antipyrine; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Ethosuximide; Humans; Liver; Lorazepam; Male; Oxidoreductases, N-Demethylating; Phenobarbital; Phenytoin; Quinidine; Rifampin; Smoking; Theophylline; Valproic Acid	1993
Pharmacokinetics of minoxidil in patients with cirrhosis and healthy volunteers. Biopharmaceutics & drug disposition, 1998, Volume: 19, Issue:8 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Area Under Curve; Biotransformation; Coloring Agents; Female; GABA Modulators; Half-Life; Humans; Indocyanine Green; Liver Cirrhosis; Liver Function Tests; Lorazepam; Male; Middle Aged; Minoxidil; Vasodilator Agents	1998

Other Studies

23 other study(ies) available for lorazepam and antipyrine

Article	Year
Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques. Journal of medicinal chemistry, 1999, Dec-16, Volume: 42, Issue:25 Topics: Animals; Biological Availability; Dogs; Humans; Least-Squares Analysis; Liver; Multivariate Analysis; Neural Networks, Computer; Pharmacokinetics; Rats	1999
ElogPoct: a tool for lipophilicity determination in drug discovery. Journal of medicinal chemistry, 2000, Jul-27, Volume: 43, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Solvents	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Effect of experimental hemorrhagic shock on hepatic drug elimination. Critical care medicine, 1992, Volume: 20, Issue:6 Topics: Animals; Antipyrine; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; Half-Life; Indocyanine Green; Liver; Lorazepam; Male; Metabolic Clearance Rate; Shock, Hemorrhagic; Spectrophotometry, Ultraviolet; Swine; Time Factors	1992
Age-related differences in hepatic drug clearance in children: studies with lorazepam and antipyrine. Clinical pharmacology and therapeutics, 1991, Volume: 50, Issue:2 Topics: Adolescent; Adult; Age Factors; Antipyrine; Body Weight; Child; Child, Preschool; Female; Humans; Injections, Intravenous; Liver; Lorazepam; Male; Metabolic Clearance Rate; Precursor Cell Lymphoblastic Leukemia-Lymphoma	1991
Effect of neurotrauma on hepatic drug clearance. Clinical pharmacology and therapeutics, 1991, Volume: 50, Issue:5 Pt 1 Topics: Adult; Aged; Antipyrine; C-Reactive Protein; Craniocerebral Trauma; Humans; Indocyanine Green; Liver; Lorazepam; Male; Metabolic Clearance Rate; Middle Aged; Orosomucoid	1991
Antipyrine plasma and urine metabolite disposition with lorazepam coadministration. Pharmacotherapy, 1991, Volume: 11, Issue:2 Topics: Antipyrine; Drug Interactions; Half-Life; Humans; Lorazepam; Male; Metabolic Clearance Rate; Pilot Projects	1991
The use of single sample clearance estimates to probe hepatic drug metabolism: handprinting the influence of cigarette smoking on human hepatic drug metabolism. Xenobiotica; the fate of foreign compounds in biological systems, 1990, Volume: 20, Issue:5 Topics: Antipyrine; Carbamazepine; Glucuronosyltransferase; Humans; Liver; Lorazepam; Male; Metabolic Clearance Rate; Microbodies; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Pharmaceutical Preparations; Polycyclic Compounds; Quinidine; Smoking; Theophylline; Valproic Acid	1990
Enhanced hepatic drug clearance in patients with cystic fibrosis. The Journal of pediatrics, 1990, Volume: 117, Issue:6 Topics: Adolescent; Adult; Antipyrine; Biotransformation; Cystic Fibrosis; Female; Humans; Indocyanine Green; Infusions, Intravenous; Liver; Lorazepam; Male; Neoplasms; Tissue Distribution	1990
Lack of effect of influenza vaccine on the pharmacokinetics of antipyrine, alprazolam, paracetamol (acetaminophen) and lorazepam. Clinical pharmacokinetics, 1989, Volume: 16, Issue:3 Topics: Acetaminophen; Adult; Alprazolam; Antipyrine; Drug Administration Schedule; Drug Interactions; Female; Humans; Influenza Vaccines; Lorazepam; Male; Middle Aged; Time Factors	1989
Antipyrine, indocyanine green, and lorazepam determined in plasma by high-pressure liquid chromatography. Clinical chemistry, 1989, Volume: 35, Issue:10 Topics: Antipyrine; Chromatography, High Pressure Liquid; Humans; Indocyanine Green; Liver; Liver Function Tests; Lorazepam; Pyrenes; Statistics as Topic	1989
Hepatic drug clearance in children with leukemia: changes in clearance of model substrates during remission-induction therapy. Clinical pharmacology and therapeutics, 1987, Volume: 41, Issue:6 Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Antipyrine; Blood Proteins; Child; Child, Preschool; Drug Interactions; Female; Humans; Indocyanine Green; Leukemia, Lymphoid; Liver; Lorazepam; Male; Metabolic Clearance Rate; Protein Binding	1987
Simultaneous administration of multiple model substrates to assess hepatic drug clearance. Clinical pharmacology and therapeutics, 1987, Volume: 41, Issue:6 Topics: Administration, Oral; Adult; Allopurinol; Antipyrine; Drug Interactions; Humans; Indocyanine Green; Infusions, Intravenous; Liver; Lorazepam; Male; Metabolic Clearance Rate	1987
Simultaneous analysis of antipyrine and lorazepam by high-performance liquid chromatography. Journal of chromatography, 1986, Oct-31, Volume: 382 Topics: Antipyrine; Chromatography, High Pressure Liquid; Flunitrazepam; Humans; Kinetics; Lorazepam; Spectrophotometry, Ultraviolet	1986
Differential effect of cimetidine on drug oxidation (antipyrine and diazepam) vs. conjugation (acetaminophen and lorazepam): prevention of acetaminophen toxicity by cimetidine. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:3 Topics: Acetaminophen; Adult; Animals; Antipyrine; Biotransformation; Cimetidine; Diazepam; Guanidines; Humans; Kinetics; Lethal Dose 50; Lorazepam; Male; Mice; Oxidation-Reduction	1983
Hepatic drug clearance in patients with mild cystic fibrosis. Clinical pharmacology and therapeutics, 1996, Volume: 59, Issue:5 Topics: Adolescent; Adult; Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Bile; Child; Chromatography, High Pressure Liquid; Coloring Agents; Cystic Fibrosis; Cytochrome P-450 Enzyme System; Female; Humans; Indocyanine Green; Infusions, Intravenous; Liver; Lorazepam; Male; Regression Analysis; Structure-Activity Relationship	1996
Liver volume as a determinant of drug clearance in children and adolescents. Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:10 Topics: Adolescent; Age Factors; Antipyrine; Child; Child, Preschool; Female; Humans; Indocyanine Green; Liver; Lorazepam; Male; Metabolic Clearance Rate	1995
Single- and multiple-dose kinetics of oral lorazepam in humans: the predictability of accumulation. Journal of pharmacokinetics and biopharmaceutics, 1979, Volume: 7, Issue:2 Topics: Administration, Oral; Adult; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Area Under Curve; Dose-Response Relationship, Drug; Female; Forecasting; Half-Life; Humans; Hypnotics and Sedatives; Lorazepam; Male; Tablets; Young Adult	1979