loratadine and piperidines

loratadine has been researched along with piperidines in 61 studies

Research

Studies (61)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (8.20)	18.7374
1990's	19 (31.15)	18.2507
2000's	30 (49.18)	29.6817
2010's	7 (11.48)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Affrime, MB; Billah, MM; Brannan, MD; Christopher, JD; Eckel, SP; Gilchrest, HG; Granzow, CA; Lawton, PJ; Radwanski, E; Richards, W	1
Billah, MM; Chapman, RW; Egan, RW; Kreutner, W; Siegel, MI; Watnick, AS	1
Billah, MM; Egan, RW; Ganguly, AK; Green, MJ; Kreutner, W; Piwinski, JJ; Siegel, MI; Villani, FJ; Wong, JK	1
Halstenson, CE; Hilbert, J; Matzke, GR; Opsahl, JA; Perentesis, G; Radwanski, E; Zampaglione, N	1
Billah, MM; Chapman, RW; Egan, RW; Gilchrest, H; Kreutner, W; Piwinski, JJ; Sherwood, J; Siegel, MI; West, RE	1
Ahn, HS; Barnett, A	1
Barnett, A; Cohen-Winston, M; Iorio, LC	1
Gural, RP; Herron, J; Kassem, N; Roman, IJ	1
Affrime, MB; Hilbert, J; Perentesis, G; Radwanski, E; Symchowicz, S; Zampaglione, N	1
Ahn, HS; Barnett, A; Gulbenkian, A; Iorio, LC; Kreutner, W; Tozzi, S	1
Bolser, DC; Chapman, RW; DeGennaro, FC; Hey, JA; O'Reilly, S	1
Bousquet, J; Campbell, AM; Crampette, L; Czarlewski, W; Mondain, M; Sauvère, G; Vignola, AM	1
O'Hanlon, JF; Ramaekers, JG	1
Bahmer, FA	1
Blume, H; Zhong, D	1
Christensen, J; Johnson, R; Lin, CC	1
Cayen, MN; Chen, KJ; Clement, RP; Huie, K; Snow, M; Yumibe, N	1
Ducic, I; Ko, CM; Morad, M; Shuba, Y	1
Caballero, R; Delpón, E; Franqueza, L; Longobardo, M; Tamargo, J; Valenzuela, C	1
Centemeri, C; Ciceri, P; Colli, S; Nicosia, S; Tosarello, D	1
Mattila, MJ; Paakkari, I	1
Danielson, L; DeVos, C; Grant, JA; Rihoux, JP	1
Billah, MM; Carruthers, NI; Chan, TM; Kaminski, JJ; McPhail, AT; Tozzi, S; Wong, SC	1
Abdelaziz, MM; Devalia, JL; Khair, OA	1
Georges, GC; Lim, JC; Ratner, PH	1
Górska, M; Grzelewska-Rzymowska, I; Pietrzkowicz, M	1
DeVos, C; Grant, JA; Moulaert, B; Riethuisen, JM	1
Fridliand, DG; Gushchin, IS; Poroshina, IuA; Shul'zhenko, AE	1
Burri, P; Karppinen, A; Kautiainen, H; Petman, L; Reunala, T	1
Paakkari, I	1
Antonijoan, R; Barbanoj, M; Esbrí, R; Garcia, E; Gich, I; Gispert, J; Luria, X	1
Amad, M; Mylchreest, I; Rudewicz, PJ; Schoen, AE; Schweingruber, H; Winnik, WM; Yang, L	1
Gras, J; Llenas, J; Llupià, J	1
Gispert, J; Hampel, F; Ratner, P	1
Boyce, M; Carey, W; Luria, X; Warrington, S	1
Chen, XY; Dong, YM; Zhang, YF; Zhong, DF	1
Alcántar, F; Herrera, J; Morales, JM; Rodríguez, JM; Rosete, R; Villacampa, J	1
Appajosyula, S; Gelfand, EW; Meeves, S	1
Hampel, F; Howland, W; Ratner, P; Van Bavel, J	2
Naidong, W; Song, Q; Zhou, S; Zhou, W	1
Chaikin, P; Gillen, MS; Malik, M; Pentikis, H; Rhodes, GR; Roberts, DJ	1
Chuecos, F; Esbrí, R; Falqués, M; Gispert, J; Luria, X; Peris, F; Ratner, P; Rosales, MJ	1
David, V; Medvedovici, A; Sora, DI; Udrescu, S	1
Antonijoan, RM; Barbanoj, MJ; Esbri, R; Fortea, J; García-Gea, C; Puntes, M; Valle, M	1
Antonijoan, R; Barbanoj, MJ; Esbrí, R; Fortea, J; García-Gea, C; Pérez, J; Puntes, M; Serra, C	1
Calmels, T; Leppaenen, J; Mach, UR; Sasse, BC; Stark, H	1
Devillier, P	1
Apostolou, C; Dotsikas, Y; Kousoulos, C; Loukas, YL	1
Bachert, C; Dimitrov, V; Gorina, MM; Ivan, P; Kuna, P; Loureiro, A; Sanquer, F; van de Heyning, P	1
Ikezawa, Z; Inomata, N; Tatewaki, S	1
Patel, BN; Sanyal, M; Sharma, N; Shrivastav, PS	1
Conrad, DH; Lichtman, AH; O'Neal, ST; Schlosburg, JE	1
Bindslev-Jensen, C; Doyle, E; Maurer, M; Metz, M; Watanabe, T; Zuberbier, T	1
Carter, NJ	1
Plichta, D; Spiewak, R	1
da Silva, J; Dos Santos, K; Locks, RB	1
Antonijoan, R; Campo, C; Coimbra, J; García-Gea, C; Gich, I; Labeaga, L; Puntes, M; Valiente, R	1

Reviews

8 review(s) available for loratadine and piperidines

Article	Year
Topical levocabastine--an effective alternative to oral antihistamines in seasonal allergic rhinoconjunctivitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1995, Volume: 25, Issue:3 Topics: Administration, Oral; Administration, Topical; Clinical Trials as Topic; Conjunctivitis, Allergic; Double-Blind Method; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Seasonal; Terfenadine	1995
Variations among non-sedating antihistamines: are there real differences? European journal of clinical pharmacology, 1999, Volume: 55, Issue:2 Topics: Astemizole; Benzimidazoles; Butyrophenones; Central Nervous System; Cetirizine; Drug Interactions; Heart; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Loratadine; Piperidines; Potassium Channel Blockers; Terfenadine; Triprolidine	1999
[The effect of second generation histamine antagonists on the heart]. Pneumonologia i alergologia polska, 2001, Volume: 69, Issue:3-4 Topics: Animals; Area Under Curve; Astemizole; Butyrophenones; Electrocardiography; Heart; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Tachycardia; Terfenadine; Torsades de Pointes	2001
Cardiotoxicity of new antihistamines and cisapride. Toxicology letters, 2002, Feb-28, Volume: 127, Issue:1-3 Topics: Arrhythmias, Cardiac; Astemizole; Benzimidazoles; Butyrophenones; Cetirizine; Cisapride; Heart Diseases; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Serotonin Receptor Agonists; Terfenadine; Triprolidine	2002
Anti-inflammatory activity of H1-receptor antagonists: review of recent experimental research. Current medical research and opinion, 2004, Volume: 20, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Butyrophenones; Cells, Cultured; Histamine H1 Antagonists; Loratadine; Piperidines; Terfenadine	2004
Meta-analysis of the efficacy of ebastine 20 mg compared to loratadine 10 mg and placebo in the symptomatic treatment of seasonal allergic rhinitis. International archives of allergy and immunology, 2005, Volume: 138, Issue:4 Topics: Adult; Butyrophenones; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Multicenter Studies as Topic; Piperidines; Placebos; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Seasonal	2005
Bilastine: in allergic rhinitis and urticaria. Drugs, 2012, Jun-18, Volume: 72, Issue:9 Topics: Area Under Curve; Benzimidazoles; Cetirizine; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Piperidines; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Perennial; Urticaria	2012
[Pharmacotherapy of urticaria--an analysis of the discrepancies between guidelines of expert bodies, registration documents and evidence for the effectiveness of drugs]. Przeglad lekarski, 2013, Volume: 70, Issue:12 Topics: Administration, Oral; Administration, Topical; Anti-Allergic Agents; Benzimidazoles; Cetirizine; Glucocorticoids; Histamine Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Piperidines; Poland; Practice Guidelines as Topic; Terfenadine; Treatment Outcome; Urticaria	2013

Trials

20 trial(s) available for loratadine and piperidines

Article	Year
Differential plasma duration of antiplatelet-activating factor and antihistamine activities of oral Sch 37370 in humans. Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:2 Topics: Administration, Oral; Adult; Double-Blind Method; Electrocardiography; Histamine Antagonists; Humans; Loratadine; Male; Piperidines; Platelet Activating Factor	1992
Suppression of histamine-induced wheal response by loratadine (SCH 29851) over 28 days in man. Annals of allergy, 1986, Volume: 57, Issue:4 Topics: Adolescent; Adult; Chlorpheniramine; Dose-Response Relationship, Drug; Histamine; Histamine Antagonists; Humans; Loratadine; Male; Piperidines; Skin; Tachyphylaxis; Time Factors	1986
Topical levocabastine compared with oral loratadine for the treatment of seasonal allergic rhinoconjunctivitis. Swedish GP Allergy Team. Allergy, 1994, Volume: 49, Issue:8 Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Aerosols; Aged; Conjunctivitis, Allergic; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Ophthalmic Solutions; Piperidines; Rhinitis, Allergic, Seasonal	1994
Antihistamine effects on actual driving performance in a standard test: a summary of Dutch experience, 1989-94. Allergy, 1995, Volume: 50, Issue:3 Topics: Automobile Driving; Benzimidazoles; Butyrophenones; Cetirizine; Clemastine; Diphenhydramine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Loratadine; Netherlands; Piperidines; Psychomotor Performance; Terfenadine; Triprolidine	1995
A double-blind, single-dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine-induced wheal and flare response for 24 h in healthy male subjects. Allergy, 1999, Volume: 54, Issue:7 Topics: Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Dibenzazepines; Double-Blind Method; Histamine; Histamine H1 Antagonists; Histamine Release; Humans; Hypersensitivity, Immediate; Imidazoles; Loratadine; Male; Piperidines; Skin Tests; Terfenadine; Urticaria	1999
Comparison of once-daily ebastine 20 mg, ebastine 10 mg, loratadine 10 mg, and placebo in the treatment of seasonal allergic rhinitis. The Ebastine Study Group. The Journal of allergy and clinical immunology, 2000, Volume: 105, Issue:6 Pt 1 Topics: Adolescent; Adult; Aged; Butyrophenones; Child; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal	2000
A double-blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo: suppression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002, Volume: 88, Issue:2 Topics: Adult; Benzimidazoles; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Histamine; Histamine H1 Antagonists; Humans; Loratadine; Male; Piperidines; Terfenadine; Treatment Outcome; Urticaria	2002
Comparison of cetirizine, ebastine and loratadine in the treatment of immediate mosquito-bite allergy. Allergy, 2002, Volume: 57, Issue:6 Topics: Adult; Animals; Butyrophenones; Cetirizine; Conscious Sedation; Cross-Over Studies; Culicidae; Double-Blind Method; Finland; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Insect Bites and Stings; Loratadine; Middle Aged; Piperidines; Pruritus; Severity of Illness Index; Time Factors; Treatment Outcome	2002
Efficacy of ebastine, cetirizine, and loratadine in histamine cutaneous challenges. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002, Volume: 89, Issue:3 Topics: Adolescent; Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Kinetics; Loratadine; Male; Middle Aged; Piperidines; Skin Tests	2002
Efficacy of ebastine in the control of nasal congestion associated with allergic rhinitis. Methods and findings in experimental and clinical pharmacology, 2003, Volume: 25, Issue:2 Topics: Adult; Ambrosia; Butyrophenones; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Nasal Obstruction; Piperidines; Rhinitis, Allergic, Seasonal	2003
Inhibition of the histamine wheal by ebastine compared with cetirizine, fexofenadine and loratadine at steady state. Drugs under experimental and clinical research, 2002, Volume: 28, Issue:6 Topics: Adolescent; Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Injections, Intradermal; Loratadine; Male; Piperidines; Skin Tests; Terfenadine	2002
Pharmacokinetics of loratadine and its active metabolite descarboethoxyloratadine in healthy Chinese subjects. Acta pharmacologica Sinica, 2003, Volume: 24, Issue:7 Topics: Administration, Oral; Adult; Antipruritics; Area Under Curve; Asian People; Humans; Loratadine; Male; Piperidines; Pyridines	2003
Pharmacokinetic properties of single-dose loratadine and ambroxol alone and combined in tablet formulations in healthy men. Clinical therapeutics, 2003, Volume: 25, Issue:8 Topics: Administration, Oral; Adolescent; Adult; Ambroxol; Area Under Curve; Cross-Over Studies; Drug Combinations; Expectorants; Histamine Antagonists; Humans; Loratadine; Male; Middle Aged; Piperidines; Pyridines; Tablets; Time Factors	2003
Efficacy and safety of ebastine 20 mg compared to loratadine 10 mg once daily in the treatment of seasonal allergic rhinitis: a randomized, double-blind, placebo-controlled study. International archives of allergy and immunology, 2004, Volume: 133, Issue:4 Topics: Adolescent; Adult; Aged; Butyrophenones; Child; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Least-Squares Analysis; Loratadine; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal	2004
A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of ebastine (20 mg and 10 mg) to loratadine 10 mg once daily in the treatment of seasonal allergic rhinitis. Journal of investigational allergology & clinical immunology, 2004, Volume: 14, Issue:1 Topics: Administration, Oral; Butyrophenones; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Loratadine; Male; Multivariate Analysis; Patch Tests; Piperidines; Probability; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Treatment Outcome	2004
Co-administration of ketoconazole with H1-antagonists ebastine and loratadine in healthy subjects: pharmacokinetic and pharmacodynamic effects. British journal of clinical pharmacology, 2005, Volume: 59, Issue:3 Topics: Adolescent; Adult; Antifungal Agents; Butyrophenones; Double-Blind Method; Drug Combinations; Electrocardiography; Heart Rate; Histamine H1 Antagonists; Humans; Ketoconazole; Loratadine; Male; Piperidines	2005
A comparison of ebastine 10 mg fast-dissolving tablet with oral desloratadine and placebo in inhibiting the cutaneous reaction to histamine in healthy adults. Clinical drug investigation, 2007, Volume: 27, Issue:7 Topics: Adult; Butyrophenones; Chemistry, Pharmaceutical; Dermatitis, Contact; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Loratadine; Male; Pain Measurement; Patient Acceptance of Health Care; Piperidines; Skin; Tablets; Treatment Outcome	2007
Comparison of inhibition of cutaneous histamine reaction of ebastine fast-dissolving tablet (20 mg) versus desloratadine capsule (5 mg): a randomized, double-blind, double-dummy, placebo-controlled, three-period crossover study in healthy, nonatopic adult Clinical therapeutics, 2007, Volume: 29, Issue:5 Topics: Adolescent; Adult; Butyrophenones; Cross-Over Studies; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Loratadine; Male; Pain Measurement; Piperidines; Pruritus; Skin; Skin Tests	2007
Comparison of the efficacy and safety of bilastine 20 mg vs desloratadine 5 mg in seasonal allergic rhinitis patients. Allergy, 2009, Volume: 64, Issue:1 Topics: Adolescent; Adult; Aged; Area Under Curve; Benzimidazoles; Child; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Loratadine; Male; Middle Aged; Piperidines; Quality of Life; Rhinitis, Allergic, Seasonal; Treatment Outcome; Young Adult	2009
Comparative efficacy of bilastine, desloratadine and rupatadine in the suppression of wheal and flare response induced by intradermal histamine in healthy volunteers. Current medical research and opinion, 2017, Volume: 33, Issue:1 Topics: Adult; Benzimidazoles; Cross-Over Studies; Cyproheptadine; Double-Blind Method; Female; Healthy Volunteers; Histamine; Histamine Antagonists; Humans; Injections, Intradermal; Loratadine; Male; Piperidines; Skin	2017

Other Studies

33 other study(ies) available for loratadine and piperidines

Article	Year
Sch 37370: a new drug combining antagonism of platelet-activating factor (PAF) with antagonism of histamine. Agents and actions. Supplements, 1991, Volume: 34 Topics: Animals; Antigens; Bronchial Spasm; Guinea Pigs; Histamine Antagonists; Humans; Hyperventilation; Loratadine; Male; Piperidines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Inbred Lew	1991
Discovery and preliminary pharmacology of Sch 37370, a dual antagonist of PAF and histamine. Lipids, 1991, Volume: 26, Issue:12 Topics: Histamine Antagonists; Humans; Kinetics; Loratadine; Male; Piperidines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Structure-Activity Relationship	1991
Pharmacokinetics of loratadine in patients with renal insufficiency. Journal of clinical pharmacology, 1990, Volume: 30, Issue:4 Topics: Adult; Cyproheptadine; Female; Humans; Kidney Failure, Chronic; Loratadine; Male; Middle Aged; Piperidines; Pyridines; Renal Dialysis; Time Factors	1990
Sch 37370: a potent, orally active, dual antagonist of platelet-activating factor and histamine. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:3 Topics: Administration, Oral; Animals; Binding, Competitive; Brain; Bronchial Spasm; Female; Guinea Pigs; Histamine; Histamine Antagonists; Humans; Loratadine; Lung; Macaca fascicularis; Male; Mice; Piperidines; Platelet Activating Factor; Platelet Aggregation; Pyrilamine; Rats	1990
Selective displacement of [3H]mepyramine from peripheral vs. central nervous system receptors by loratadine, a non-sedating antihistamine. European journal of pharmacology, 1986, Aug-07, Volume: 127, Issue:1-2 Topics: Aminopyridines; Animals; Binding, Competitive; Cerebral Cortex; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Kinetics; Loratadine; Lung; Male; Piperidines; Pyrilamine; Receptors, Cell Surface	1986
Interaction studies in mice of SCH 29851, a potential non-sedating antihistamine, with commonly used therapeutic agents. Agents and actions, 1986, Volume: 18, Issue:5-6 Topics: Animals; Benzhydryl Compounds; Diphenhydramine; Dose-Response Relationship, Drug; Electroshock; Hexobarbital; Histamine Antagonists; Loratadine; Male; Mice; Motor Activity; Piperidines; Reflex; Seizures; Stereotyped Behavior; Terfenadine; Vocalization, Animal	1986
Excretion of loratadine in human breast milk. Journal of clinical pharmacology, 1988, Volume: 28, Issue:3 Topics: Adult; Cyproheptadine; Female; Histamine Antagonists; Humans; Loratadine; Milk, Human; Piperidines; Pyridines	1988
Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamine. Agents and actions, 1984, Volume: 14, Issue:5-6 Topics: Animals; Anticonvulsants; Autonomic Nervous System; Behavior, Animal; Binding, Competitive; Cerebral Cortex; Dioxanes; Dogs; Female; Guinea Pigs; Histamine; Histamine Antagonists; Hypnotics and Sedatives; Lethal Dose 50; Loratadine; Male; Mice; Physostigmine; Piperidines; Pyrilamine; Rats; Saimiri; Time Factors	1984
Pharmacological studies of allergic cough in the guinea pig. European journal of pharmacology, 1995, Apr-24, Volume: 277, Issue:2-3 Topics: Administration, Oral; Aerosols; Albuterol; Analysis of Variance; Animals; Antitussive Agents; Capsaicin; Chlorpheniramine; Cimetidine; Codeine; Cough; Drug Hypersensitivity; Guinea Pigs; Hexamethonium; Histamine Antagonists; Indomethacin; Injections, Subcutaneous; Ipratropium; Loratadine; Male; Ovalbumin; Piperidines; Receptors, Histamine H1; Receptors, Histamine H2	1995
Inhibitory activity of loratadine and descarboethoxyloratadine on expression of ICAM-1 and HLA-DR by nasal epithelial cells. Allergy, 1995, Volume: 50, Issue:3 Topics: Adult; Histamine; Histamine H1 Antagonists; HLA-DR Antigens; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1; Loratadine; Middle Aged; Nasal Mucosa; Nasal Polyps; Piperidines; Pyridines; Turbinates	1995
[HPLC-determination of loratadine and its active metabolite descarboethoxyloratadine in human plasma]. Die Pharmazie, 1994, Volume: 49, Issue:10 Topics: Chromatography, High Pressure Liquid; Humans; Loratadine; Piperidines; Pyridines; Spectrometry, Fluorescence	1994
Sensitive gas-liquid chromatographic method for the determination of loratadine and its major active metabolite, descarboethoxyloratadine, in human plasma using a nitrogen-phosphorus detector. Journal of chromatography. B, Biomedical applications, 1994, Jul-01, Volume: 657, Issue:1 Topics: Child; Chromatography, Gas; Female; Humans; Hydrogen-Ion Concentration; Loratadine; Male; Nitrogen; Phosphorus; Piperidines; Pyridines; Sensitivity and Specificity	1994
Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6. Biochemical pharmacology, 1996, Jan-26, Volume: 51, Issue:2 Topics: Anti-Bacterial Agents; Antifungal Agents; Antimalarials; Binding Sites; Biotransformation; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Histamine H1 Antagonists; Humans; In Vitro Techniques; Ketoconazole; Loratadine; Microsomes, Liver; Mixed Function Oxygenases; Models, Molecular; Oxidation-Reduction; Piperidines; Pyridines; Quinidine; Recombinant Proteins; Substrate Specificity; Troleandomycin	1996
Comparative effects of loratadine and terfenadine on cardiac K+ channels. Journal of cardiovascular pharmacology, 1997, Volume: 30, Issue:1 Topics: Animals; Cation Transport Proteins; Ether-A-Go-Go Potassium Channels; Gene Expression; Guinea Pigs; Heart Ventricles; Histamine H1 Antagonists; In Vitro Techniques; Loratadine; Male; Membrane Potentials; Myocardium; Oocytes; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Wistar; Recombinant Proteins; Terfenadine; Xenopus laevis	1997
Effect of descarboethoxyloratadine, the major metabolite of loratadine, on the human cardiac potassium channel Kv1.5. British journal of pharmacology, 1997, Volume: 122, Issue:5 Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Heart Ventricles; Humans; Ion Channel Gating; Kv1.5 Potassium Channel; Loratadine; Membrane Potentials; Mice; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines	1997
Heterogeneous platelet-activating factor (PAF) receptors and calcium increase in platelets and macrophages. Biochemical pharmacology, 1999, Feb-01, Volume: 57, Issue:3 Topics: Animals; Azepines; Blood Platelets; Calcium; Cytosol; Humans; Loratadine; Macrophages; Male; Piperidines; Platelet Membrane Glycoproteins; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles	1999
Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine. Bioorganic & medicinal chemistry, 1999, Volume: 7, Issue:7 Topics: Animals; Anti-Allergic Agents; Crystallography, X-Ray; Drug Design; Drug Evaluation, Preclinical; Guinea Pigs; Histamine Antagonists; Humans; Inhibitory Concentration 50; Isoquinolines; Loratadine; Mice; Models, Molecular; Molecular Conformation; Molecular Mimicry; Piperazines; Piperidines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridines; Rats; Receptors, Histamine H1; Stereoisomerism; Structure-Activity Relationship	1999
The potential of active metabolites of antihistamines in the management of allergic disease. Allergy, 2000, Volume: 55, Issue:5 Topics: Anti-Inflammatory Agents; Butyrophenones; Cells, Cultured; Cetirizine; Chymases; Eosinophils; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Cell Growth Factors; Histamine; Histamine H1 Antagonists; Humans; Hypersensitivity; Intercellular Adhesion Molecule-1; Interleukin-3; Interleukin-8; Loratadine; Mast Cells; Piperidines; Potassium Channel Blockers; Potassium Channels; Prostaglandin D2; Pyridines; Recombinant Fusion Proteins; Recombinant Proteins; Serine Endopeptidases; Terfenadine; Time Factors; Tryptases	2000
[Comparative antihistamine and anti-allergic effects of various antihistamine preparations]. Terapevticheskii arkhiv, 2002, Volume: 74, Issue:3 Topics: Adult; Anti-Allergic Agents; Butyrophenones; Cetirizine; Clemastine; Female; Histamine H1 Antagonists; Humans; Hypersensitivity; Loratadine; Male; Piperidines; Pollen; Terfenadine	2002
Investigation of an enhanced resolution triple quadrupole mass spectrometer for high-throughput liquid chromatography/tandem mass spectrometry assays. Rapid communications in mass spectrometry : RCM, 2002, Volume: 16, Issue:21 Topics: Calibration; Chromatography, High Pressure Liquid; Loratadine; Mometasone Furoate; Pharmaceutical Preparations; Piperidines; Pregnadienediols; Pyridines; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization	2002
Comparative antiallergic effects of second-generation H1-antihistamines ebastine, cetirizine and loratadine in preclinical models. Arzneimittel-Forschung, 2003, Volume: 53, Issue:2 Topics: Aerosols; Airway Resistance; Algorithms; Animals; Anti-Allergic Agents; Bronchial Spasm; Butyrophenones; Cetirizine; Guinea Pigs; Histamine; Histamine H1 Antagonists; Leukotriene C4; Loratadine; Male; Ovalbumin; Piperidines	2003
[Antihistaminics. Side effects also after raising dosage at the placebo level]. MMW Fortschritte der Medizin, 2003, May-29, Volume: 145, Issue:22 Topics: Anti-Allergic Agents; Benzimidazoles; Butyrophenones; Cetirizine; Double-Blind Method; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Meta-Analysis as Topic; Piperidines; Placebos; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal	2003
[In seasonal and perennial rhinitis. Superiority to standard H1 blockers]. MMW Fortschritte der Medizin, 2003, May-29, Volume: 145, Issue:22 Topics: Anti-Allergic Agents; Butyrophenones; Cetirizine; Double-Blind Method; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Multicenter Studies as Topic; Piperidines; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Time Factors	2003
Direct injection of 96-well organic extracts onto a hydrophilic interaction chromatography/tandem mass spectrometry system using a silica stationary phase and an aqueous/organic mobile phase. Rapid communications in mass spectrometry : RCM, 2004, Volume: 18, Issue:23 Topics: Chromatography, Liquid; Humans; Loratadine; Omeprazole; Pharmaceutical Preparations; Piperidines; Protease Inhibitors; Pyridines; Reserpine; Spectrometry, Mass, Electrospray Ionization	2004
Validated ion pair liquid chromatography/fluorescence detection method for assessing the variability of the loratadine metabolism occurring in bioequivalence studies. Biomedical chromatography : BMC, 2007, Volume: 21, Issue:10 Topics: Administration, Oral; Adolescent; Adult; Chromatography, High Pressure Liquid; Drug Stability; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Molecular Structure; Piperidines; Pyridines; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Therapeutic Equivalency	2007
Hybrid approach for the design of highly affine and selective dopamine D(3) receptor ligands using privileged scaffolds of biogenic amine GPCR ligands. Bioorganic & medicinal chemistry, 2007, Dec-01, Volume: 15, Issue:23 Topics: Amines; Animals; Binding, Competitive; Cell Line; Cetirizine; CHO Cells; Cricetinae; Cricetulus; Dopamine D2 Receptor Antagonists; Drug Design; Drug Evaluation, Preclinical; Histamine H1 Antagonists; Humans; Ketotifen; Ligands; Loratadine; Mianserin; Molecular Structure; Piperidines; Receptors, Dopamine D3; Stereoisomerism; Structure-Activity Relationship	2007
Comparison of inhibition of cutaneous histamine reaction of ebastine fast-dissolving tablet [20 mg] versus desloratadine capsule [5 mg]: a randomized, double-blind, double-dummy, placebo-controlled, three-period crossover study in healthy, nonatopic adult Clinical therapeutics, 2007, Volume: 29, Issue:12 Topics: Butyrophenones; Histamine; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Randomized Controlled Trials as Topic; Skin Tests	2007
Comparison of hydrophilic interaction and reversed-phase liquid chromatography coupled with tandem mass spectrometric detection for the determination of three pharmaceuticals in human plasma. Biomedical chromatography : BMC, 2008, Volume: 22, Issue:12 Topics: Cetirizine; Chromatography, Liquid; Donepezil; Humans; Indans; Loratadine; Piperidines; Reproducibility of Results; Tandem Mass Spectrometry	2008
Multiple H1-antihistamine-induced urticaria. The Journal of dermatology, 2009, Volume: 36, Issue:4 Topics: Administration, Oral; Adult; Drug Eruptions; Female; Histamine; Histamine H1 Antagonists; Humans; Immunologic Tests; Leukotriene B4; Loratadine; Piperidines; Pyridines; Skin Tests; Terfenadine; Urticaria	2009
LC-MS-ESI for the determination of loratadine and descarboethoxyloratadine in human plasma. Journal of chromatographic science, 2010, Volume: 48, Issue:1 Topics: Chromatography, Liquid; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Piperidines; Pyridines; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tablets; Tandem Mass Spectrometry; Therapeutic Equivalency; Time Factors	2010
CB1 receptors mediate rimonabant-induced pruritic responses in mice: investigation of locus of action. Psychopharmacology, 2011, Volume: 216, Issue:3 Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Female; Histamine H1 Antagonists; Hypersensitivity; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Loratadine; Male; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain; Piperidines; Pruritus; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant	2011
Effects of antihistamines on innate immune responses to severe bacterial infection in mice. International archives of allergy and immunology, 2011, Volume: 155, Issue:4 Topics: Animals; Anti-Allergic Agents; Bacterial Infections; Diphenhydramine; Histamine Antagonists; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Histamine H3 Antagonists; Humans; Immunity, Innate; Loratadine; Mice; Mice, Inbred C57BL; Peritonitis; Piperidines; Receptors, Histamine; Sepsis	2011
Quality of life in patients with allergic rhinitis: a clinical trial comparing the use of bilastine versus loratadine. Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 2017, Volume: 42, Issue:2 Topics: Adolescent; Adult; Anti-Allergic Agents; Benzimidazoles; Brazil; Double-Blind Method; Female; Humans; Loratadine; Male; Middle Aged; Piperidines; Prospective Studies; Quality of Life; Rhinitis, Allergic; Treatment Outcome	2017