loratadine has been researched along with desloratadine in 397 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.25) | 18.7374 |
| 1990's | 9 (2.27) | 18.2507 |
| 2000's | 225 (56.68) | 29.6817 |
| 2010's | 131 (33.00) | 24.3611 |
| 2020's | 31 (7.81) | 2.80 |
| Authors | Studies |
|---|---|
| Albanese, MM; Anthes, JC; Billah, MM; Colizzo, F; Ganguly, AK; Green, MJ; Kaminski, JJ; Piwinski, JJ; West, RE; Wong, JK | 1 |
| Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ | 1 |
| Arrington, MP; Bayless, L; Cai, X; Collart, P; Eckman, JB; Ellis, JL; Ene, DG; Lewis, TA; Libertine, L; Nicolas, JM; Scannell, RT; Wels, BF; Wenberg, K; Wypij, DM; Young, MA | 1 |
| Chen, GW; Liu, GZ; Liu, HM; Wang, P; Wang, YN; Xu, HW; Yu, DQ | 1 |
| DeGraw, AJ; Distefano, MD; Keiser, MJ; Ochocki, JD; Shoichet, BK | 1 |
| Ang, KK; Arkin, MR; Chen, S; Doyle, PS; Engel, JC; McKerrow, JH | 1 |
| Gust, R; Huang, W; Liu, W; Qian, H; Zhang, H; Zhang, T; Zhou, J; Zhu, H | 1 |
| Hitchcock, SA | 1 |
| Cheng, Y; Gust, R; Liu, W; Zhang, H; Zhang, T; Zhou, J; Zhu, H | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Buschauer, A; Cuboni, S; Devigny, C; Eder, M; Hauger, B; Hausch, F; Höfner, G; Holsboer, F; Hoogeland, B; Pomplun, S; Strasser, A; Wanner, KT | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Bassyouni, A; Bradow, J; Brown, M; Bundesmann, M; Chen, J; Ciszewski, G; Hagen, AE; Hyek, D; Jenkinson, S; Lall, MS; Liu, B; Obach, RS; Pan, S; Reilly, U; Sach, N; Smaltz, DJ; Spracklin, DK; Starr, J; Wagenaar, M; Walker, GS | 1 |
| Halstenson, CE; Hilbert, J; Matzke, GR; Opsahl, JA; Perentesis, G; Radwanski, E; Zampaglione, N | 1 |
| Affrime, MB; Hilbert, J; Perentesis, G; Radwanski, E; Symchowicz, S; Zampaglione, N | 1 |
| Bousquet, J; Campbell, AM; Crampette, L; Czarlewski, W; Mondain, M; Sauvère, G; Vignola, AM | 1 |
| Blume, H; Zhong, D | 1 |
| Christensen, J; Johnson, R; Lin, CC | 1 |
| Cayen, MN; Chen, KJ; Clement, RP; Huie, K; Snow, M; Yumibe, N | 1 |
| Ducic, I; Ko, CM; Morad, M; Shuba, Y | 1 |
| Caballero, R; Delpón, E; Franqueza, L; Longobardo, M; Tamargo, J; Valenzuela, C | 1 |
| Antón, F; Beleta, J; Cardelús, I; Palacios, JM | 1 |
| Anthes, J; Barnett, A; Hey, JA; Kreutner, W; Tozzi, S; Young, S | 1 |
| Abdelaziz, MM; Devalia, JL; Khair, OA | 1 |
| Barnett, A; Chiu, P; Hey, JA; Kreutner, W | 1 |
| Affrime, MB; Banfield, C; Herron, JM; Lorber, R; Padhi, D; Salmun, LM | 1 |
| Bachert, C | 3 |
| Baena-Cagnani, CE | 1 |
| Gauger, A; Hein, R; Ring, J | 1 |
| Bonini, S | 1 |
| Henz, BM | 1 |
| Bronsky, E; Gauger, A; Hein, R; Miller, B; Ring, J | 1 |
| Geha, RS; Meltzer, EO | 1 |
| Affrime, M; Banfield, C; Batra, V; Clement, R; Gupta, S; Kantesaria, B; Marino, M | 1 |
| Jarvis, B; McClellan, K | 1 |
| Agrawal, DK | 2 |
| Degitz, K; Holgate, ST; Johnston, SL; Papadopoulos, NG; Papi, A; Stanciu, LA | 1 |
| Barecki, ME; Casciano, CN; Clement, RP; Johnson, WW | 1 |
| Kreutner, W; Lichtenstein, LM; Schleimer, RP; Schroeder, JT | 1 |
| Nayak, AS; Schenkel, E | 1 |
| Wilson, AM | 1 |
| Affrime, M; Banfield, C; Gupta, S; Lim, J; Marino, M | 1 |
| Harris, AG; Horak, F; Stübner, UP; Zieglmayer, R | 1 |
| Lorber, R; Salmun, LM | 1 |
| Anthes, JC; Billah, M; Eckel, S; Egan, RE; Gilchrest, H; Greenfeder, S; Hesk, D; Kreutner, W; Richard, C; West, RE; Williams, SM | 1 |
| Affrime, M; Banfield, C; Cayen, M; Gupta, S; Herron, J; Marco, A; Padhi, D | 1 |
| Affrime, M; Banfield, C; Glue, P; Gupta, S; Marbury, T; Padhi, D | 1 |
| Affrime, M; Banfield, C; Cohen, A; Gupta, S | 1 |
| Affrime, M; Banfield, C; Boutros, T; Cayen, M; Cohen, A; Gupta, S; Thonoor, M | 1 |
| Affrime, M; Banfield, C; Hunt, T; Padhi, D; Reyderman, L; Statkevich, P | 1 |
| Affrime, M; Banfield, C; Herron, J; Keung, A; Padhi, D | 1 |
| Haggart, K; Lipworth, BJ; Sims, EJ; Wilson, AM | 1 |
| Amad, M; Mylchreest, I; Rudewicz, PJ; Schoen, AE; Schweingruber, H; Winnik, WM; Yang, L | 1 |
| Andersson, M; Greiff, L; Persson, CG | 1 |
| Berger, WE; Mansfield, LE; Schenkel, EJ | 1 |
| Horak, F | 1 |
| Van Cauwenberge, P | 1 |
| Monroe, EW | 1 |
| Kockler, DR; Limon, L | 1 |
| Sabbah, A | 1 |
| Bates, CE; Currie, GP; Lee, DK; Lipworth, BJ | 1 |
| Finn, A; Prenner, BM; Simons, FE | 1 |
| Jackson, CM; Lee, DK; Lipworth, BJ | 1 |
| Bernstein, D; Finn, A; Guerrero, R; Monroe, E; Patel, P; Ratner, P | 1 |
| Baena-Cagnani, CE; Berger, WE; Danzig, M; DuBuske, LM; Gurné, SE; Lorber, R; Stryszak, P | 1 |
| Harris, AG; Horak, F; Stübner, P; Zieglmeyer, R | 1 |
| Anderson, SD; Brannan, JD; Currie, GP; Fowler, SJ; Haggart, K; Lee, DK; Lipworth, BJ; Wilson, AM | 1 |
| Anderson, SD; Currie, GP; Haggart, K; Lee, DK; Lipworth, BJ | 1 |
| Bryce, PJ; Geha, R; Oettgen, HC | 1 |
| Farkas, H | 1 |
| Scheinfeld, N | 1 |
| Chen, XY; Dong, YM; Zhang, YF; Zhong, DF | 1 |
| Beaudry, F; Clement, RP; Di Donato, L; Grandmaison, C; Kantesaria, B; Masse, R; Reyderman, L; Rudewicz, PJ; Yang, L | 1 |
| Glass, DJ; Harper, AS | 1 |
| Handford, AD; Nicholson, AN; Stone, BM; Turner, C | 1 |
| Crampton, HJ | 1 |
| Berger, WE; White, MV | 1 |
| Goa, KL; Keam, SJ; Murdoch, D | 1 |
| Frossard, N; Melac, M; Pauli, G; Purohit, A | 2 |
| Dösch, A; Kraemer, DM; Schöttker, B | 1 |
| Alcántar, F; Herrera, J; Morales, JM; Rodríguez, JM; Rosete, R; Villacampa, J | 1 |
| Grzelewska-Rzymowska, I | 1 |
| Briscoe, MP; Day, JH; Ellis, AK; Kane, RL; Rafeiro, E; Sullivan, CL; Wilken, JA | 1 |
| See, S | 1 |
| Appajosyula, S; Gelfand, EW; Meeves, S | 1 |
| Juhlin, L | 1 |
| Dewan, M; Satish, U; Streufert, S; Voort, SV | 1 |
| Li, H; Liu, L; Qi, M; Wang, P | 1 |
| Glass, D; Harper, A | 1 |
| Briscoe, MP; Day, JH; Rafeiro, E; Ratz, JD | 1 |
| Fujihara, S; Gardiner, M; Haggart, K; Lee, DK; Lipworth, BJ | 1 |
| Berney, M; Deruaz, C; Leimgruber, A; Pradervand, E; Spertini, F | 1 |
| Rikken, G; Simons, RM; Valk, PJ; Van Roon, DB | 1 |
| de Halleux, F; Muntjewerff, ND; Ramaekers, JG; Rikken, GH; Vuurman, EF | 1 |
| Ciprandi, G; Cirillo, I; Tosca, MA; Vizzaccaro, A | 1 |
| Baiardini, I; Canonica, GW; Compalati, E; Fumagalli, F; Guerra, L; Massacane, P; Pasquali, M | 1 |
| Blümchen, K; Gerhold, K; Hamelmann, E; Seib, C; Thorade, I; Wahn, U | 1 |
| Benedetti, MS; Diquet, B; Molimard, M | 1 |
| Alton, KB; Alvarez, N; Chowdhury, SK; Ghosal, A; Hapangama, N; Patrick, JE; Su, AD; Yuan, Y; Zbaida, S | 1 |
| Bindslev-Jensen, C; Kim, H | 1 |
| Baena-Cagnani, R; Canonica, GW; Compalati, E; Guerra, L; Massacane, P; Passalacqua, G; Rogkakou, A; Zanella, C | 1 |
| Colanardi, MC; Ferrannini, A; Nettis, E; Paradiso, MT | 1 |
| Di Lorenzo, G; Ditta, V; Esposito Pellitteri, M; Lo Bianco, C; Mansueto, P; Martinelli, N; Pacor, ML; Rini, GB | 1 |
| Blair, C; Kirtsreesakul, V; Naclerio, RM; Thompson, K; Yu, X | 1 |
| Banfield, C; Flannery, B; Gupta, S; Herron, J; Kantesaria, B | 1 |
| Keseru, GM; Kiss, R; Kovári, Z | 1 |
| Naidong, W; Song, Q; Zhou, S; Zhou, W | 1 |
| Currie, GP; Lee, DK | 1 |
| Anthes, JC; Harris, AG; Kreutner, W; West, RE; Wu, RL | 1 |
| Alexander, P; Davie, C; Mitcheson, J; Pierre-Valentin, J; Pollard, C; Standen, N; Thong, B | 1 |
| DuBuske, L; Jankowski, A; Kowalski, ML; Lewandowska, A; Makowska, J; Wozniak, J | 1 |
| Daly, AF; Harris, AG; Kreutner, W; Taché, Y; Wang, YH; Wei, JY | 1 |
| Chen, GG; Leung, PC; Liu, SX; van Hasselt, CA; Wong, YO; Woo, KS; Zhao, Y | 1 |
| Bianchi, B; Canonica, GW; Le Grazie, C; Passalacqua, G; Rossi, GA; Tosca, MA | 1 |
| Bloom, M; Herron, J; Staudinger, H | 1 |
| Baroody, FM; Bhatia, S; deTineo, M; Naclerio, RM | 1 |
| Grubbe, R; Lutsky, B; Pleskow, W; Weiss, S | 1 |
| Li, X | 1 |
| Geng, Y; Qi, M; Wang, P | 1 |
| Chow, MS; Shi, XJ; Tomlinson, B; Yin, OQ | 1 |
| de Francisco, R; Pérez, R; Rodrigo, L | 1 |
| Conboy-Ellis, K | 1 |
| Chen, ZG; Huang, MZ; Lu, XY; Sheng-Tu, JZ; Zheng, GG; Zhou, HL | 1 |
| Leung, P; Van Hasselt, CA; Wong, Y; Woo, K; Zhao, Y | 1 |
| Hayes, RN; Shen, JX; Tadros, S; Wang, H | 1 |
| Howell, G; Jenkins, C; Lineberry, B; Rockhold, R; West, L; Yokum, D | 1 |
| Braunstahl, GJ; Fokkens, WJ; Hoogsteden, HC; Kleinjan, A; Overbeek, SE; Reinartz, SM; van Drunen, CM | 1 |
| Elbirt, D; Rottem, M; Sthoeger, Z | 1 |
| Canonica, GW; Passalacqua, G | 1 |
| Cockcroft, DW; Davis, BE; Todd, DC | 1 |
| Baatjes, AJ; Crawford, L; Cyr, MM; Denburg, JA; Hayes, LM; Keith, PK | 1 |
| Kirtsreesakul, V; Klemens, JJ; Luxameechanporn, T; Naclerio, RM | 1 |
| DuBuske, LM | 1 |
| Baltes, E; Benedetti, MS; Chatelain, P; Gillard, M | 1 |
| Allen, M; Barberi, S; Ciprandi, G; Cirillo, I; Civardi, E; Marseglia, GL; Vizzaccaro, A | 1 |
| Berger, WE | 1 |
| Havránek, E; Kubacák, P; Mikus, P; Valásková, I | 1 |
| Alobid, I; Bernal-Sprekelsen, M; Mullol, J; Picado, C; Pujols, L; Roca-Ferrer, J; Valero, A; Xaubet, A | 1 |
| Horak, F; Kavina, A; Marschall, K; Munzel, U; Petzold, U; Zieglmayer, R; Zieglmayer, UP | 1 |
| Aydemir, O; Bayrak, P; Degirmenci, S; Kirmaz, C; Ozenturk, O; Yuksel, H | 1 |
| Leung, PC; Liang, CY; van Hasselt, CA; Wong, YO; Woo, KS; Zhao, Y | 1 |
| Shedden, A | 1 |
| Harris, AG; Iezzoni, D; Jalowayski, AA; Meltzer, EO; Vogt, K | 1 |
| Gupta, S; Kantesaria, B; Khalilieh, S; Kim, K; Lorber, R; Lutsky, B; Manitpisitkul, P; Prenner, B; Wang, Z | 1 |
| Boonen, H; De Swerdt, A; Decroix, J; Henrijean, A; Lachapelle, JM; Lecuyer, M; Roquet-Gravy, PP; Speelman, G; Suys, E; Vastesaeger, N | 1 |
| Hansen, RA; Trygstad, TK; Wegner, SE | 1 |
| Bocheńska-Marciniak, M; Górski, P; Kuna, P; Kupczyk, M; Tworek, D | 1 |
| Gates, D; Hébert, J; Kim, K; Lumry, W; Lutsky, B; Sussman, G | 1 |
| Amoruso, A; Cassano, N; D'Argento, V; Filieri, M; Filotico, R; Raho, G; Vena, GA | 1 |
| Angello, JT; Druce, HM; Raphael, GD; Wu, MM | 1 |
| Behrendt, H; Münster, I; Ring, J; Traidl-Hoffmann, C | 1 |
| Bhatt, PM; Desiraju, GR | 1 |
| Bidstrup, TB; Brosen, K; Damkier, P; Nielsen, F; Noehr-Jensen, L; Pedersen, RS | 1 |
| Chen, GG; Leung, PC; van Hasselt, CA; Wang, LH; Wong, YO; Woo, JK; Zhao, Y | 1 |
| Blaiss, MS | 1 |
| Bachvarova, A; Bocsan, C; Church, MK; Dimitrov, V; Dumitrascu, D; Popov, TA | 1 |
| Boshier, A; Cornelius, V; Harris, S; Layton, D; Shakir, SA; Wilton, L | 1 |
| Colanardi, MC; Ferrannini, A; Nettis, E; Soccio, AL; Vacca, A | 1 |
| Belal, FF; El-Enany, N; El-Sherbiny, DT; Hansen, SH | 1 |
| Camelo-Nunes, IC | 1 |
| Ciebiada, M; DuBuske, LM; Górska-Ciebiada, M; Górski, P | 1 |
| Blaiss, MS; Lehman, JM | 1 |
| Berkowitz, D; Scharf, M | 1 |
| Auquier, P; Dreyfus, I; Grob, JJ; Ortonne, JP | 3 |
| Banfield, C; Gupta, SK; Kantesaria, B; Wang, Z | 1 |
| Kruszewski, J; Kłos, K; Sułek, K | 1 |
| Kruszewski, J; Kruszewski, R; Kłos, K; Sułek, K | 1 |
| Adalioglu, G; Dizdar, EA; Dogan, C; Kalayci, O; Keskin, O; Sekerel, BE; Tuncer, A | 1 |
| Alobid, I; Mullol, J; Valero, A | 1 |
| Canonica, GW; Compalati, E; Penagos, M; Tarantini, F | 1 |
| Banfield, C; Gupta, S; Kantesaria, B; Khalilieh, S | 1 |
| David, V; Medvedovici, A; Sora, DI; Udrescu, S | 1 |
| Devillier, P; Dreyfus, I; Neukirch, C; Pradalier, A | 1 |
| Gamper, S; Heinze, G; Hemmer, W; Kinaciyan, T; Stingl, G; Wöhrl, S | 1 |
| Antonijoan, RM; Barbanoj, MJ; Esbri, R; Fortea, J; García-Gea, C; Puntes, M; Valle, M | 1 |
| Keith, PK; Luciuk, G | 1 |
| Alton, KB; Alvarez, N; Chowdhury, SK; Clement, RP; Patrick, JE; Ramanathan, R; Reyderman, L; Statkevich, P; Su, AD; Wirth, MA | 1 |
| Lam, HC; Tong, MC; Van Hasselt, CA | 1 |
| Antonijoan, R; Barbanoj, MJ; Esbrí, R; Fortea, J; García-Gea, C; Pérez, J; Puntes, M; Serra, C | 1 |
| Carbó, ML; Izquierdo, I; Merlos, M; Nadal, T; Peña, J; Solans, A | 1 |
| Clement, RP; Hayes, RN; Merka, EA; Shen, JX; Tama, CI; Xu, Y | 1 |
| Calli, C; Eryigit, O; Oncel, S; Pinar, E; Yilmaz, O; Yuksel, H | 1 |
| Bocheńska-Marciniak, M; Bogacka, E; Kuna, P; Kupczyk, M; Sterchaluk-Grzyb, E; Tworek, D | 1 |
| Buczyłko, K; Chwała, C; Dzwonnik, A; Wagner, A; Zielińska-Bliźniewska, H | 1 |
| DuBuske, L | 1 |
| Gupta, SK; Kantesaria, B; Wang, Z | 1 |
| Chen, WL; Chu, NN; Li, XN; Xu, HR | 1 |
| Frossard, N; Pauli, G; Purohit, A; Strolin-Benedetti, M | 1 |
| Bandaru, VV; Patel, RS; Rao, AA; Rao, MN; Shedbalkar, VP; Srinubabu, G | 1 |
| Bachert, C; van Cauwenberge, P | 1 |
| Belal, F; El-Enany, N; El-Sherbiny, D | 1 |
| Abdalla, AN; Khalaf, AT; Liu, XM; Sheng, WX; Tan, JQ | 1 |
| Engin, B; Ozdemir, M | 1 |
| Chimona, TS; Helidonis, ES; Panayiotides, JG; Papadakis, CE; Velegrakis, GA | 1 |
| Devillier, P | 1 |
| Devillier, P; Faisy, C; Roche, N | 1 |
| Kiratli, H; Onder, S; Ozşeker, H; Yildiz, S | 1 |
| Goebel, MU; Hengge, UR; Kou, W; Meykadeh, N; Schedlowski, M | 1 |
| Barbaud, A; Bursztejn, AC; Schmutz, JL; Trechot, P | 1 |
| Cui, Y; Gao, Q; Liu, Z; Xu, K; You, X | 1 |
| Kluger, N | 1 |
| Li, Y; Liu, F | 1 |
| Antonijoan, R; Barbanoj, M; Carbó, ML; Donado, E; Izquierdo, I; Merlos, M; Nadal, T; Peña, J; Solans, A | 1 |
| Chen, G; Daaro, I; Piwinski, JJ; Pramanik, BN | 1 |
| Ciebiada, M; Ciebiada, MG; DuBuske, LM; Gorski, P; Kmiecik, T | 1 |
| Agbaba, D; Cakar, M; Popović, G | 1 |
| Finlay, AY; Guillet, G; Hauptmann, P; Jian, AM; Kapp, A; Maurer, M; Potter, PC | 1 |
| Fan, G; Hong, Z; Wei, H; Wen, J; Wu, Y | 1 |
| Bachert, C; Dimitrov, V; Gorina, MM; Ivan, P; Kuna, P; Loureiro, A; Sanquer, F; van de Heyning, P | 1 |
| Boulet, LP; Cockcroft, DW; Davis, BE; Deschesnes, F; Gauvreau, GM; Illamperuma, C; O'Byrne, PM; Watson, RM | 1 |
| Srinivas, NR | 1 |
| Degener, F; Martus, P; Maurer, M; Siebenhaar, F; Zuberbier, T | 1 |
| Layton, D; Shakir, SA; Wilton, L | 1 |
| Aberer, W; Groselj-Strele, A; Heinemann, A; Kranzelbinder, B; Sturm, EM; Sturm, GJ | 2 |
| Maharaj, B; Manjra, AI; Nel, H | 1 |
| Gomes, P; Gopalan, G; Srinivasan, S; Torkildsen, GL; Welch, D | 1 |
| Bachmann, K; Bykowski, C; Dhananjeyan, M; Erhardt, P; Hacker, M; Katta, A; White, DB | 1 |
| Augustin, M; Ehrle, S | 1 |
| Anolik, R | 1 |
| Anolik, R; Grubbe, RE; Lumry, WR | 1 |
| Maurer, M; Weller, K | 1 |
| dos Santos, RV; Lima, HC; Magerl, M; Mlynek, A | 1 |
| Scadding, G; Valovirta, E | 1 |
| Bachert, C; Bindslev Jensen, C; Bousquet, J; Canonica, GW; Fokkens, WJ; Keith, P; Lorber, R; Mullol, J; Ring, J; Van Cauwenberge, P; Zuberbier, T | 1 |
| Bagad, AS; Bahekar, PC; Chidrewar, GU; Mandhane, SN; Mehetre, SV; Pawar, CA; Rajamannar, T; Rao, CT; Shah, JH | 1 |
| Alton, KB; Alvarez, N; Chowdhury, SK; Ghosal, A; Gupta, S; Lu, X; Ramanathan, R; Su, AD; Yuan, Y; Zbaida, S | 1 |
| Cougnard, J; Devillier, P; Dreyfus, I; Holmberg, K; Mesbah, K; Olsson, P; Tonnel, AB | 1 |
| Rustum, AM; Zheng, J | 1 |
| Demoly, P; Dhivert-Donnadieu, H; Dreyfus, I; Mesbah, K | 1 |
| Chakole, D; Malleswara Reddy, A; Mukkanti, K; Rao, DD; Sait, SS; Satyanarayana, NV | 1 |
| Eliashar, R; Levi-Schaffer, F | 1 |
| Baskan, EB; Budak, F; Erturk, E; Gul, OO; Hacioglu, S; Imamoglu, S; Kiyici, S | 1 |
| Moeller, ML; Nahata, MC; Phan, H | 1 |
| Patel, BN; Sanyal, M; Sharma, N; Shrivastav, PS | 1 |
| Bachert, C; Maurer, M | 1 |
| Angelini, G; Antelmi, A; Bonamonte, D; Cassano, N; Foti, C; Nettis, E; Vena, GA | 1 |
| Church, DS; Church, MK; Dimitrov, V; Kraeva, S; Kralimarkova, T; Lazarova, C; Popov, TA; Popova, D; Staevska, M | 1 |
| Lorber, R; Navaratnam, P; Shekar, T; Sullivan, PW | 1 |
| Bieszczad-Bedrejczuk, E; Rachel, M; Sadowska-Woda, I | 1 |
| Bérard, F; Boulinguez, S | 1 |
| Bachert, C; Bousquet, J; Canonica, GW; Fokkens, WJ; Gopalan, G; Jensen, CB; Keith, P; Lorber, R; Mullol, J; Ring, J; Van Cauwenberge, P; Zuberbier, T | 1 |
| Eigelshoven, S; Homey, B; Korkmaz, H | 1 |
| Chu, CY; Hong, JB; Hu, FC; Lee, HC | 1 |
| Sackesen, C; Sahiner, UM; Tuncer, A; Yavuz, ST | 1 |
| Bindslev-Jensen, C; Doyle, E; Maurer, M; Metz, M; Watanabe, T; Zuberbier, T | 1 |
| Alobid, I; de Borja Callejas, F; Martínez-Antón, MA; Méndez-Arancibia, E; Mullol, J; Picado, C; Pujols, L; Roca-Ferrer, J; Valero, A | 1 |
| Bobadilla-González, P; Cámara-Hijón, C; García-Menaya, JM; Pérez-Rangel, I; Sánchez-Vega, S | 1 |
| Chaker, AM; Dumitru, AF; Greve, J; Hess, L; Hindersin, S; Klenzner, T; Nebel, S; Scheckenbach, K; Schmidt-Weber, CB; Shamji, M; Wagenmann, M; Zahner, C; Zimmermann, C | 1 |
| Chu, CY; Hong, JB; Lee, HC | 1 |
| Langner, C; Siegel, C; Thonhofer, R; Trummer, M | 1 |
| Bourke, J; Roper, S | 1 |
| Miller, SD; Padval, MV; Podojil, JR | 1 |
| Bain, LJ; Green, BR | 1 |
| Crowe, A; Wright, C | 1 |
| Maatouk, I; Moutran, R; Obeid, G; Stephan, F | 1 |
| Church, MK; Magerl, M; Martus, P; Maurer, M; Pisarevskaja, D; Staubach, P | 1 |
| Hakooz, N; Salem, II | 1 |
| Akhmedov, IG; Gadzhimirzaev, GA; Mikhrailova, ZT; Muradova, GR | 1 |
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46 review(s) available for loratadine and desloratadine
| Article | Year |
|---|---|
Structural modifications that alter the P-glycoprotein efflux properties of compounds.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line; Central Nervous System Agents; Central Nervous System Diseases; Drug Design; Humans; Models, Molecular; Permeability; Structure-Activity Relationship | 2012 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Decongestant efficacy of desloratadine in patients with seasonal allergic rhinitis.
Topics: Chemotaxis, Leukocyte; Cholinergic Antagonists; Eosinophils; Histamine H1 Antagonists; Humans; Loratadine; Platelet Activating Factor; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Time Factors; Treatment Outcome | 2001 |
Desloratadine activity in concurrent seasonal allergic rhinitis and asthma.
Topics: Asthma; Cholinergic Antagonists; Eosinophils; Histamine H1 Antagonists; Humans; Loratadine; Respiratory Function Tests; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Treatment Outcome | 2001 |
Desloratadine in the treatment of chronic idiopathic urticaria.
Topics: Cholinergic Antagonists; Chronic Disease; Cytokines; Histamine H1 Antagonists; Humans; Loratadine; Severity of Illness Index; Time Factors; Treatment Outcome; Urticaria | 2001 |
Desloratadine: a new approach in the treatment of allergy as a systematic disease--pharmacology and clinical overview. Introduction.
Topics: Cholinergic Antagonists; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Histamine H1 Antagonists; Humans; Hypersensitivity; Loratadine; Treatment Outcome | 2001 |
The pharmacologic profile of desloratadine: a review.
Topics: Cholinergic Antagonists; Drug Monitoring; Histamine H1 Antagonists; Humans; Loratadine; Time Factors; Treatment Outcome | 2001 |
Pharmacology and clinical efficacy of desloratadine as an anti-allergic and anti-inflammatory drug.
Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Humans; Loratadine | 2001 |
Are antihistamines useful in managing asthma?
Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchospirometry; Cetirizine; Cyclopropanes; Drug Therapy, Combination; Histamine H1 Antagonists; Humans; Loratadine; Mannitol; Quinolines; Rhinitis; Sulfides; Terfenadine | 2002 |
Therapeutic points of intervention and clinical implications: role of desloratadine.
Topics: Asthma; Clinical Trials as Topic; Drug Administration Schedule; Histamine H1 Antagonists; Humans; Loratadine; Rhinitis, Allergic, Perennial; Urticaria | 2002 |
Impact and modulation of nasal obstruction.
Topics: Histamine H1 Antagonists; Humans; Loratadine; Nasal Obstruction; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Seasonal | 2002 |
Advances in allergy management.
Topics: Histamine H1 Antagonists; Humans; Inflammation Mediators; Loratadine; Nasal Obstruction; Quality of Life; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 2002 |
Desloratidine for the treatment of chronic urticaria.
Topics: Chronic Disease; Histamine H1 Antagonists; Humans; Loratadine; Urticaria | 2002 |
Desloratadine: a nonsedating antihistamine.
Topics: Adult; Area Under Curve; Child; Female; Half-Life; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Seasonal; Urticaria | 2003 |
[The place of new antihistamines in allergy management. Apropos of desloratadine].
Topics: Anti-Allergic Agents; Double-Blind Method; Half-Life; Histamine H1 Antagonists; Histamine Release; Humans; Hypersensitivity, Immediate; Inflammation Mediators; Intercellular Adhesion Molecule-1; Liver; Loratadine; Meta-Analysis as Topic; Multicenter Studies as Topic; Patient Acceptance of Health Care; Randomized Controlled Trials as Topic; Recombinant Proteins; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Safety; Treatment Outcome; Urticaria | 2002 |
The new antihistamines--desloratadine and levocetirizine: a review.
Topics: Acetates; Animals; Area Under Curve; Cetirizine; Half-Life; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivity; Loratadine; Piperazines; Randomized Controlled Trials as Topic | 2002 |
Desloratadine: an update of its efficacy in the management of allergic disorders.
Topics: Animals; Clinical Trials as Topic; Drug Interactions; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivity; Loratadine | 2003 |
[Clinical aspects of anti-inflammatory action of antihistamines].
Topics: Cetirizine; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivity; Loratadine; Piperazines; Terfenadine | 2003 |
Desloratadine for allergic rhinitis.
Topics: Administration, Oral; Adolescent; Adult; Drug Administration Schedule; Drug Costs; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Treatment Outcome | 2003 |
Anti-inflammatory activity of H1-receptor antagonists: review of recent experimental research.
Topics: Animals; Anti-Inflammatory Agents; Butyrophenones; Cells, Cultured; Histamine H1 Antagonists; Loratadine; Piperidines; Terfenadine | 2004 |
Antihistamines: do they work? Further well-controlled trials involving larger samples are needed.
Topics: Anti-Allergic Agents; Anti-Inflammatory Agents; Cetirizine; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivity; Loratadine; Piperazines; Quality of Life | 2004 |
Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans.
Topics: Absorption; Animals; Area Under Curve; Benzimidazoles; Biological Availability; Cetirizine; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Metabolic Clearance Rate; Piperazines; Terfenadine; Tissue Distribution | 2004 |
Anti-inflammatory properties of desloratadine.
Topics: Cell Adhesion; Cytokines; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Models, Immunological; Respiratory Hypersensitivity; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; T-Lymphocytes, Helper-Inducer | 2004 |
Management of seasonal allergic rhinitis: comparative efficacy of the newer-generation prescription antihistamines.
Topics: Adolescent; Adult; Cetirizine; Child; Child, Preschool; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Nurse Practitioners; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome | 2005 |
A review of the evidence from comparative studies of levocetirizine and desloratadine for the symptoms of allergic rhinitis.
Topics: Cetirizine; Histamine Antagonists; Humans; Loratadine; Nose; Piperazines; Quality of Life; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Skin; Urticaria | 2005 |
Review of desloratadine for the treatment of allergic rhinitis, chronic idiopathic urticaria and allergic inflammatory disorders.
Topics: Adult; Aged; Animals; Anti-Inflammatory Agents; Asthma; Child; Child, Preschool; Chronic Disease; Clinical Trials, Phase III as Topic; Drug Administration Schedule; Histamine H1 Antagonists, Non-Sedating; Humans; Infant; Loratadine; Product Surveillance, Postmarketing; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Urticaria | 2005 |
The safety and efficacy of desloratadine for the management of allergic disease.
Topics: Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Product Surveillance, Postmarketing; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Urticaria | 2005 |
A review of the evidence from comparative studies of levocetirizine and desloratadine for the symptoms of allergic rhinitis.
Topics: Cetirizine; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Piperazines; Retrospective Studies; Rhinitis, Allergic, Seasonal; Treatment Outcome | 2006 |
Adult and paediatric poor metabolisers of desloratadine: an assessment of pharmacokinetics and safety.
Topics: Administration, Oral; Age Factors; Dose-Response Relationship, Drug; Electrocardiography; Histamine H1 Antagonists, Non-Sedating; Loratadine; Rhinitis, Allergic, Seasonal; Urticaria | 2006 |
New antihistamines: a critical view.
Topics: Anti-Allergic Agents; Blood-Brain Barrier; Central Nervous System Diseases; Cetirizine; Child; Cyproheptadine; Heart Diseases; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivity; Loratadine; Mast Cells; Piperazines; Receptors, Histamine H1; Terfenadine | 2006 |
Selecting the optimal oral antihistamine for patients with allergic rhinitis.
Topics: Administration, Oral; Cardiovascular System; Central Nervous System; Cetirizine; Drug Interactions; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Long QT Syndrome; Loratadine; Piperazines; Practice Guidelines as Topic; Quality of Life; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome | 2006 |
Efficacy of desloratadine in the treatment of allergic rhinitis: a meta-analysis of randomized, double-blind, controlled trials.
Topics: Double-Blind Method; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivity; Loratadine; Nasal Obstruction; Randomized Controlled Trials as Topic; Rhinitis; Treatment Outcome | 2007 |
Desloratadine for chronic idiopathic urticaria: a review of clinical efficacy.
Topics: Acetates; Adolescent; Adult; Child; Chronic Disease; Cyclopropanes; Drug Therapy, Combination; Histamine H1 Antagonists, Non-Sedating; Humans; Infant; Leukotriene Antagonists; Loratadine; Quality of Life; Quinolines; Sulfides; Urticaria | 2007 |
Desloratadine treatment for intermittent and persistent allergic rhinitis: a review.
Topics: Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Practice Guidelines as Topic; Quality of Life; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 2007 |
Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review.
Topics: Cetirizine; Drug Interactions; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Terfenadine; Urticaria | 2008 |
Desloratadine and pseudoephedrine combination therapy as a comprehensive treatment for allergic rhinitis and nasal congestion.
Topics: Clinical Trials as Topic; Drug Combinations; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Nasal Decongestants; Nasal Obstruction; Pseudoephedrine; Quality of Life; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 2009 |
A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cetirizine; Child; Clinical Trials as Topic; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Nasal Obstruction; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outcome; Young Adult | 2009 |
Safety and efficacy of desloratadine in subjects with seasonal allergic rhinitis or chronic urticaria: results of four postmarketing surveillance studies.
Topics: Activities of Daily Living; Adult; Anti-Allergic Agents; Chronic Disease; Female; Germany; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Nasal Obstruction; Pregnancy; Product Surveillance, Postmarketing; Pruritus; Rhinitis, Allergic, Seasonal; Sleep; Sneezing; Structure-Activity Relationship; Treatment Outcome; Urticaria | 2010 |
[Diagnostic and physiopathological innovations related to chronic urticaria].
Topics: Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Autoantibodies; Autoimmune Diseases; Blood Coagulation; Chronic Disease; Drug Eruptions; Female; Histamine H1 Antagonists, Non-Sedating; Histamine Release; Humans; Iodide Peroxidase; Loratadine; Mast Cells; Middle Aged; Omalizumab; Penicillins; Urticaria | 2010 |
Bilastine: in allergic rhinitis and urticaria.
Topics: Area Under Curve; Benzimidazoles; Cetirizine; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Piperidines; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Perennial; Urticaria | 2012 |
H(1)-antihistamines and urticaria: how can we predict the best drug for our patient?
Topics: Anti-Allergic Agents; Cetirizine; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Predictive Value of Tests; Skin Tests; Terfenadine; Urticaria | 2012 |
Safety evaluation of desloratadine in allergic rhinitis.
Topics: Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Rhinitis, Allergic; Rhinitis, Allergic, Perennial | 2013 |
H1-antihistamines for chronic spontaneous urticaria.
Topics: Cetirizine; Cyproheptadine; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Randomized Controlled Trials as Topic; Urticaria | 2014 |
Treatment effect of sublingual immunotherapy tablets and pharmacotherapies for seasonal and perennial allergic rhinitis: Pooled analyses.
Topics: Ambrosia; Anti-Allergic Agents; Humans; Loratadine; Mometasone Furoate; Phleum; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sublingual Immunotherapy; Tablets; Treatment Outcome | 2016 |
[Meta-analysis of efficacy and safety of Tripterygium Glycosides Tablets combined with desloratadine in treatment of chronic urticarial].
Topics: Drug Therapy, Combination; Drugs, Chinese Herbal; Glycosides; Humans; Loratadine; Quality of Life; Randomized Controlled Trials as Topic; Tablets; Tripterygium; Urticaria | 2019 |
Efficiency and safety of desloratadine in combination with compound glycyrrhizin in the treatment of chronic urticaria: a meta-analysis and systematic review of randomised controlled trials.
Topics: Anti-Inflammatory Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chronic Urticaria; Drug Therapy, Combination; Glycyrrhizic Acid; Histamine H1 Antagonists, Non-Sedating; Humans; Immunoglobulin E; Loratadine; Randomized Controlled Trials as Topic | 2021 |
131 trial(s) available for loratadine and desloratadine
| Article | Year |
|---|---|
The pharmacokinetics, electrocardiographic effects, and tolerability of loratadine syrup in children aged 2 to 5 years.
Topics: Anti-Allergic Agents; Biological Availability; Child, Preschool; Double-Blind Method; Drug Administration Schedule; Electrocardiography; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Pharmaceutic Aids; Placebos; Rhinitis, Allergic, Seasonal; Urticaria | 2000 |
Once-daily desloratadine improves the signs and symptoms of chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Cholinergic Antagonists; Chronic Disease; Dizziness; Double-Blind Method; Drug Administration Schedule; Fatigue; Female; Headache; Humans; Loratadine; Male; Middle Aged; Pharyngitis; Pruritus; Respiratory Tract Infections; Treatment Outcome; Urticaria; Virus Diseases | 2001 |
Pharmacokinetic and safety profile of desloratadine and fexofenadine when coadministered with azithromycin: a randomized, placebo-controlled, parallel-group study.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Azithromycin; Electrocardiography; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Terfenadine | 2001 |
Desloratadine reduces nasal congestion in patients with intermittent allergic rhinitis.
Topics: Adolescent; Adult; Aged; Child; Circadian Rhythm; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Nasal Decongestants; Nasal Mucosa; Nasal Obstruction; Rhinitis, Allergic, Seasonal; Treatment Outcome; United States | 2001 |
Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine.
Topics: Administration, Oral; Adult; Area Under Curve; Beverages; Biological Availability; Citrus; Confidence Intervals; Cross-Over Studies; Electrocardiography; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Terfenadine | 2002 |
Effect of desloratadine versus placebo on nasal airflow and subjective measures of nasal obstruction in subjects with grass pollen-induced allergic rhinitis in an allergen-exposure unit.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Nasal Obstruction; Poaceae; Pollen; Rhinitis, Allergic, Seasonal; Sneezing | 2002 |
24-hour efficacy of once-daily desloratadine therapy in patients with seasonal allergic rhinitis [ISRCTN32042139].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Child; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Rhinitis, Allergic, Seasonal | 2002 |
Desloratadine demonstrates dose proportionality in healthy adults after single doses.
Topics: Adult; Area Under Curve; Cross-Over Studies; Dose-Response Relationship, Drug; Half-Life; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged | 2002 |
Oral bioavailability of desloratadine is unaffected by food.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Female; Food; Histamine H1 Antagonists; Humans; Loratadine; Male | 2002 |
Effect of race and sex on single and multiple dose pharmacokinetics of desloratadine.
Topics: Administration, Oral; Adult; Area Under Curve; Black People; Drug Administration Schedule; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Sex Factors; White People | 2002 |
Lack of clinically relevant interaction between desloratadine and erythromycin.
Topics: Adult; Anti-Bacterial Agents; Area Under Curve; Cross-Over Studies; Drug Interactions; Electrocardiography; Erythromycin; Female; Half-Life; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged | 2002 |
Desloratadine has no clinically relevant electrocardiographic or pharmacodynamic interactions with ketoconazole.
Topics: Adult; Analysis of Variance; Antifungal Agents; Area Under Curve; Cross-Over Studies; Drug Interactions; Electrocardiography; Female; Histamine H1 Antagonists; Humans; Ketoconazole; Loratadine; Male; Middle Aged | 2002 |
Effects of fexofenadine and desloratadine on subjective and objective measures of nasal congestion in seasonal allergic rhinitis.
Topics: Adult; Air Pollutants; Allergens; Cross-Over Studies; Double-Blind Method; Environmental Exposure; Female; Forced Expiratory Volume; Histamine H1 Antagonists; Humans; Loratadine; Lung; Male; Pollen; Rhinitis, Allergic, Seasonal; Terfenadine | 2002 |
Desloratadine reduces allergen challenge-induced mucinous secretion and plasma exudation in allergic rhinitis.
Topics: Adolescent; Adult; Allergens; alpha-Macroglobulins; Betula; Cross-Over Studies; Double-Blind Method; Female; Fucose; Histamine H1 Antagonists; Humans; Loratadine; Male; Nasal Lavage Fluid; Nasal Mucosa; Plasma; Poaceae; Pollen; Rhinitis, Allergic, Seasonal | 2002 |
Safety and efficacy of desloratadine 5 mg in asthma patients with seasonal allergic rhinitis and nasal congestion.
Topics: Adolescent; Adult; Aged; Asthma; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Rhinitis, Allergic, Seasonal; Treatment Outcome | 2002 |
Comparative in vivo bioactivity of modern H1-antihistamines on AMP challenge in atopic asthma.
Topics: Acetates; Adenosine Monophosphate; Adult; Aged; Asthma; Bronchial Provocation Tests; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Piperazines; Respiratory Hypersensitivity; Terfenadine | 2003 |
Efficacy and safety of desloratadine in the treatment of perennial allergic rhinitis.
Topics: Adolescent; Adult; Aged; Child; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Patient Dropouts; Rhinitis, Allergic, Perennial; Safety | 2003 |
Efficacy and safety of desloratadine 5 mg once daily in the treatment of chronic idiopathic urticaria: a double-blind, randomized, placebo-controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Child; Chronic Disease; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Urticaria | 2003 |
Comparative effects of desloratadine versus montelukast on asthma symptoms and use of beta 2-agonists in patients with seasonal allergic rhinitis and asthma.
Topics: Acetates; Adolescent; Adrenergic beta-Agonists; Adult; Aged; Albuterol; Anti-Asthmatic Agents; Asthma; Cyclopropanes; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Pulmonary Ventilation; Quinolines; Rhinitis, Allergic, Seasonal; Sulfides; Treatment Outcome | 2003 |
Comparison of the effects of desloratadine 5-mg daily and placebo on nasal airflow and seasonal allergic rhinitis symptoms induced by grass pollen exposure.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Environmental Exposure; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Nasal Cavity; Nasal Mucosa; Placebos; Poaceae; Pollen; Pulmonary Ventilation; Rhinitis, Allergic, Seasonal | 2003 |
Effects of mediator antagonism on mannitol and adenosine monophosphate challenges.
Topics: Acetates; Adenosine Monophosphate; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Cyclopropanes; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Leukotriene Antagonists; Loratadine; Male; Mannitol; Middle Aged; Quinolines; Sulfides; Time Factors | 2003 |
The effects of histamine and leukotriene receptor antagonism on nasal mannitol challenge in allergic rhinitis.
Topics: Acetates; Adult; Cross-Over Studies; Cyclopropanes; Diuretics, Osmotic; Double-Blind Method; Histamine H1 Antagonists, Non-Sedating; Humans; Inspiratory Capacity; Loratadine; Mannitol; Middle Aged; Nasal Provocation Tests; Quinolines; Rhinitis, Allergic, Seasonal; Sulfides | 2003 |
[Multicenter study of the effectiveness and tolerability of desloratadine in seasonal allergic rhinitis].
Topics: Adult; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Rhinitis, Allergic, Seasonal; Treatment Outcome | 2003 |
Pharmacokinetics of loratadine and its active metabolite descarboethoxyloratadine in healthy Chinese subjects.
Topics: Administration, Oral; Adult; Antipruritics; Area Under Curve; Asian People; Humans; Loratadine; Male; Piperidines; Pyridines | 2003 |
Studies on performance and sleepiness with the H1-antihistamine, desloratadine.
Topics: Adult; Affect; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Mental Recall; Psychomotor Performance; Sleep | 2003 |
Comparison of ketotifen fumarate ophthalmic solution alone, desloratadine alone, and their combination for inhibition of the signs and symptoms of seasonal allergic rhinoconjunctivitis in the conjunctival allergen challenge model: a double-masked, placebo
Topics: Adolescent; Adult; Aged; Allergens; Anti-Allergic Agents; Child; Conjunctivitis, Allergic; Double-Blind Method; Drug Therapy, Combination; Female; Histamine H1 Antagonists; Humans; Ketotifen; Loratadine; Male; Middle Aged; Ophthalmic Solutions; Rhinitis, Allergic, Seasonal; Time Factors | 2003 |
Efficacy of azelastine nasal spray in patients with an unsatisfactory response to loratadine.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Allergic Agents; Child; Double-Blind Method; Drug Therapy, Combination; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Phthalazines; Rhinitis, Allergic, Seasonal; Sneezing | 2003 |
Twenty-four-hour activity and consistency of activity of levocetirizine and desloratadine in the skin.
Topics: Adolescent; Adult; Cetirizine; Circadian Rhythm; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Skin; Urticaria | 2003 |
Pharmacokinetic properties of single-dose loratadine and ambroxol alone and combined in tablet formulations in healthy men.
Topics: Administration, Oral; Adolescent; Adult; Ambroxol; Area Under Curve; Cross-Over Studies; Drug Combinations; Expectorants; Histamine Antagonists; Humans; Loratadine; Male; Middle Aged; Piperidines; Pyridines; Tablets; Time Factors | 2003 |
A comparison of the effect of diphenhydramine and desloratadine on vigilance and cognitive function during treatment of ragweed-induced allergic rhinitis.
Topics: Allergens; Ambrosia; Anti-Allergic Agents; Arousal; Cognition; Diphenhydramine; Double-Blind Method; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Neuropsychological Tests; Rhinitis, Allergic, Seasonal; Treatment Outcome | 2003 |
Inhibition of cold urticaria by desloratadine.
Topics: Adolescent; Adult; Aged; Cold Temperature; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Patient Satisfaction; Urticaria | 2004 |
Improvements in simulated real-world relevant performance for patients with seasonal allergic rhinitis: impact of desloratadine.
Topics: Adolescent; Adult; Cross-Over Studies; Decision Making; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Mental Processes; Middle Aged; Rhinitis, Allergic, Seasonal | 2004 |
Comparative clinical efficacy, onset and duration of action of levocetirizine and desloratadine for symptoms of seasonal allergic rhinitis in subjects evaluated in the Environmental Exposure Unit (EEU).
Topics: Adolescent; Adult; Cetirizine; Cohort Studies; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Piperazines; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Treatment Outcome | 2004 |
Comparative effects of desloratadine, fexofenadine, and levocetirizine on nasal adenosine monophosphate challenge in patients with perennial allergic rhinitis.
Topics: Adenosine Monophosphate; Adult; Aged; Aged, 80 and over; Anti-Allergic Agents; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Nasal Provocation Tests; Piperazines; Rhinitis, Allergic, Perennial; Terfenadine; Treatment Outcome | 2004 |
Levocetirizine better protects than desloratadine in a nasal provocation with allergen.
Topics: Adult; Albumins; Allergens; Biomarkers; Cetirizine; Cross-Over Studies; Differential Threshold; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivity; Loratadine; Male; Nasal Lavage Fluid; Nasal Provocation Tests; Piperazines; Poaceae; Pollen; Treatment Outcome | 2004 |
Desloratadine shows no effect on performance during 6 h at 8,000 ft simulated cabin altitude.
Topics: Administration, Oral; Adolescent; Adult; Aerospace Medicine; Affect; Analysis of Variance; Anti-Allergic Agents; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Oximetry; Psychomotor Performance; Sleep; Statistics, Nonparametric | 2004 |
Effects of desloratadine, diphenhydramine, and placebo on driving performance and psychomotor performance measurements.
Topics: Adult; Automobile Driving; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Psychomotor Performance | 2004 |
Levocetirizine improves nasal obstruction and modulates cytokine pattern in patients with seasonal allergic rhinitis: a pilot study.
Topics: Adult; Cetirizine; Double-Blind Method; Eosinophils; Female; Histamine H1 Antagonists; Humans; Interleukin-4; Interleukin-8; Leukocyte Count; Loratadine; Male; Nasal Lavage Fluid; Nasal Obstruction; Pilot Projects; Piperazines; Rhinitis, Allergic, Seasonal; Statistics, Nonparametric | 2004 |
Comparative activity of cetirizine and desloratadine on histamine-induced wheal-and-flare responses during 24 hours.
Topics: Adolescent; Adult; Anti-Allergic Agents; Area Under Curve; Cetirizine; Cross-Over Studies; Female; Histamine; Humans; Loratadine; Male; Middle Aged; Skin Tests; Time Factors; Urticaria | 2004 |
Comparison of the effects in the nose and skin of a single dose of desloratadine and levocetirizine over 24 hours.
Topics: Adolescent; Adult; Cetirizine; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Nose; Piperazines; Rhinitis; Skin; Skin Tests; Treatment Outcome | 2004 |
Desloratadine in combination with montelukast in the treatment of chronic urticaria: a randomized, double-blind, placebo-controlled study.
Topics: Acetates; Administration, Oral; Adolescent; Adult; Aged; Chronic Disease; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Leukotriene Antagonists; Loratadine; Male; Middle Aged; Pruritus; Quality of Life; Quinolines; Severity of Illness Index; Sulfides; Treatment Outcome; Urticaria | 2004 |
Randomized placebo-controlled trial comparing desloratadine and montelukast in monotherapy and desloratadine plus montelukast in combined therapy for chronic idiopathic urticaria.
Topics: Acetates; Adolescent; Adult; Aged; Chronic Disease; Cyclopropanes; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Leukotriene Antagonists; Loratadine; Male; Middle Aged; Quinolines; Sulfides; Treatment Outcome; Urticaria | 2004 |
Pharmacokinetics/pharmacodynamics of desloratadine and fluoxetine in healthy volunteers.
Topics: Adolescent; Adult; Anti-Allergic Agents; Area Under Curve; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Electrocardiography; Female; Fluoxetine; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Selective Serotonin Reuptake Inhibitors | 2004 |
Evidence of desloratadine syrup efficacy and tolerability in children with pollen-induced allergic rhinitis.
Topics: Child; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Pollen; Rhinitis, Allergic, Seasonal; Treatment Outcome | 2005 |
Safety of desloratadine syrup in children.
Topics: Acute Disease; Administration, Oral; Child; Child, Preschool; Double-Blind Method; Electrocardiography; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Placebos; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Urticaria | 2004 |
Increased nasal airflow with budesonide compared with desloratadine during the allergy season.
Topics: Administration, Intranasal; Administration, Oral; Adolescent; Adult; Budesonide; Cross-Sectional Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Loratadine; Male; Middle Aged; Probability; Pulmonary Ventilation; Quality of Life; Respiratory Mechanics; Rhinitis, Allergic, Perennial; Severity of Illness Index; Statistics, Nonparametric; Treatment Outcome | 2005 |
Efficacy and safety of an extended-release formulation of desloratadine and pseudoephedrine vs the individual components in the treatment of seasonal allergic rhinitis.
Topics: Adolescent; Adult; Aged; Child; Double-Blind Method; Drug Combinations; Ephedrine; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Nasal Decongestants; Nasal Obstruction; Rhinitis, Allergic, Seasonal; Treatment Outcome | 2005 |
Effect of cyp2d6*10 allele on the pharmacokinetics of loratadine in chinese subjects.
Topics: Adult; Alleles; Anti-Allergic Agents; Asian People; Cytochrome P-450 CYP2D6; Genotype; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Polymorphism, Genetic | 2005 |
Desloratadine reduces systemic allergic inflammation following nasal provocation in allergic rhinitis and asthma patients.
Topics: Adult; Asthma; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Inflammation; Loratadine; Male; Nasal Provocation Tests; Poaceae; Pollen; Rhinitis, Allergic, Seasonal; Treatment Outcome | 2005 |
[Desloratadine for chronic idiopathic urticaria].
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Israel; Loratadine; Male; Middle Aged; Patient Satisfaction; Surveys and Questionnaires; Urticaria | 2005 |
Effect of combined montelukast and desloratadine on the early asthmatic response to inhaled allergen.
Topics: Acetates; Adult; Allergens; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Cross-Over Studies; Cyclopropanes; Drug Therapy, Combination; Female; Forced Expiratory Volume; Humans; Loratadine; Male; Middle Aged; Quinolines; Sulfides; Time Factors | 2005 |
The effect of desloratadine on eosinophil/basophil progenitors and other inflammatory markers in seasonal allergic rhinitis: a placebo-controlled randomized study.
Topics: Adolescent; Adult; Basophils; Cytokines; Eosinophils; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Leukocyte Count; Loratadine; Male; Middle Aged; Nasal Lavage Fluid; Pollen; Rhinitis, Allergic, Seasonal; Stem Cells | 2005 |
Desloratadine and levocetirizine improve nasal symptoms, airflow, and allergic inflammation in patients with perennial allergic rhinitis: a pilot study.
Topics: Adolescent; Adult; Cetirizine; Double-Blind Method; Eosinophils; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Inflammation; Interleukin-4; Leukocyte Count; Loratadine; Male; Nasal Lavage Fluid; Nasal Mucosa; Nasal Obstruction; Pilot Projects; Piperazines; Rhinitis, Allergic, Perennial; Rhinomanometry | 2005 |
Azelastine nasal spray and desloratadine tablets in pollen-induced seasonal allergic rhinitis: a pharmacodynamic study of onset of action and efficacy.
Topics: Administration, Intranasal; Adolescent; Adult; Anti-Allergic Agents; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Phthalazines; Pollen; Rhinitis, Allergic, Seasonal; Tablets; Treatment Outcome | 2006 |
Effect of desloratadine therapy on symptom scores and measures of nasal patency in seasonal allergic rhinitis: results of a single-center, placebo-controlled trial.
Topics: Adult; Demography; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Nasal Cavity; Nasal Obstruction; Placebos; Quality of Life; Rhinitis, Allergic, Seasonal; Seasons; Surveys and Questionnaires | 2006 |
Desloratadine 5 mg once daily improves the quality of life of patients with chronic idiopathic urticaria.
Topics: Administration, Oral; Adult; Belgium; Chronic Disease; Drug Administration Schedule; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Quality of Life; Severity of Illness Index; Treatment Outcome; Urticaria | 2006 |
The effect of 4 weeks treatment with desloratadine (5mg daily) on levels of interleukin (IL)-4, IL-10, IL-18 and TGF beta in patients suffering from seasonal allergic rhinitis.
Topics: Adult; Drug Administration Schedule; Enzyme-Linked Immunosorbent Assay; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Interleukin-10; Interleukin-18; Interleukin-4; Interleukins; Loratadine; Male; Recurrence; Rhinitis, Allergic, Seasonal; Sleep Wake Disorders; Time Factors; Transforming Growth Factor beta; Treatment Outcome | 2007 |
Desloratadine therapy for symptoms associated with perennial allergic rhinitis.
Topics: Adolescent; Adult; Aged; Child; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Rhinitis, Allergic, Perennial; Treatment Outcome | 2006 |
Influence of desloratadine on oxidative stress markers in patients with chronic idiopathic urticaria.
Topics: Adult; Aged; Biomarkers; Chronic Disease; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Oxidative Stress; Reactive Oxygen Species; Severity of Illness Index; Superoxide Dismutase; Urticaria | 2006 |
Efficacy of diphenhydramine vs desloratadine and placebo in patients with moderate-to-severe seasonal allergic rhinitis.
Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Child; Diphenhydramine; Double-Blind Method; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Nasal Decongestants; Nasal Obstruction; Rhinitis, Allergic, Seasonal | 2006 |
A comparison of levocetirizine and desloratadine in the histamine-induced wheal and flare response in human skin in vivo.
Topics: Adult; Cetirizine; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivity, Immediate; Loratadine; Male; Middle Aged; Piperazines; Skin; Skin Tests; Urticaria | 2006 |
Comparison of the risk of drowsiness and sedation between levocetirizine and desloratadine: a prescription-event monitoring study in England.
Topics: Adult; Cetirizine; Cohort Studies; Conscious Sedation; Drug Monitoring; England; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Piperazines; Rhinitis; Sleep Stages | 2006 |
Desloratadine in combination with montelukast suppresses the dermographometer challenge test papule, and is effective in the treatment of delayed pressure urticaria: a randomized, double-blind, placebo-controlled study.
Topics: Acetates; Administration, Oral; Adolescent; Adult; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Leukotriene Antagonists; Loratadine; Male; Middle Aged; Pressure; Quinolines; Skin Tests; Sulfides; Urticaria | 2006 |
Montelukast with desloratadine or levocetirizine for the treatment of persistent allergic rhinitis.
Topics: Acetates; Adolescent; Adult; Aged; Anti-Asthmatic Agents; Cetirizine; Cross-Over Studies; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Eosinophil Cationic Protein; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Nasal Lavage Fluid; Piperazines; Quinolines; Rhinitis, Allergic, Perennial; Rhinometry, Acoustic; Sulfides; Treatment Outcome | 2006 |
Effects of desloratadine and alcohol coadministration on psychomotor performance.
Topics: Adult; Arousal; Ataxia; Double-Blind Method; Drug Interactions; Ethanol; Fatigue; Female; Headache; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Nausea; Psychomotor Performance; Reaction Time; Vomiting | 2007 |
Efficacy and safety of desloratadine in adults with chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled, multicenter trial.
Topics: Adult; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Pruritus; Severity of Illness Index; Treatment Outcome; Urticaria | 2007 |
Desloratadine dose selection in children aged 6 months to 2 years: comparison of population pharmacokinetics between children and adults.
Topics: Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Infant; Loratadine; Male | 2007 |
[Inhibition of histamine-induced wheel after a recommended single dose administration of 10 mg cetirizine, 5 mg desloratadine, 120 i 180 mg fexofenadine, 5 mg levocetirizine and 10 mg loratadine--a randomized, double-blind, placebo controlled trial].
Topics: Administration, Oral; Adult; Cetirizine; Double-Blind Method; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Laser-Doppler Flowmetry; Loratadine; Male; Piperazines; Placebos; Skin; Skin Tests; Terfenadine; Treatment Outcome; Urticaria | 2006 |
[The effect of 5-days of cetirizine, desloratadine, fexofenadine 120 and 180 mg, levocetirizine, loratadine treatment on the histamine-induced skin reaction and skin blood flow--a randomized, double-blind, placebo controlled trial].
Topics: Administration, Oral; Adult; Cetirizine; Double-Blind Method; Drug Administration Schedule; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Laser-Doppler Flowmetry; Loratadine; Male; Piperazines; Regional Blood Flow; Skin; Skin Tests; Terfenadine; Treatment Outcome; Urticaria | 2006 |
The effect of regular versus on-demand desloratadine treatment in children with allergic rhinitis.
Topics: Adolescent; Albuterol; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bronchodilator Agents; Child; Drug Administration Schedule; Eosinophil Cationic Protein; Eosinophils; Ephedrine; Female; Forced Expiratory Volume; Histamine H1 Antagonists, Non-Sedating; Humans; Immunoglobulin E; Loratadine; Male; Methacholine Chloride; Nasal Mucosa; Nasal Provocation Tests; Pollen; Prospective Studies; Rhinitis, Allergic, Seasonal; Secretory Rate | 2007 |
Pharmacokinetics of desloratadine in children between 2 and 11 years of age.
Topics: Adult; Aging; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male | 2007 |
Desloratadine improves quality of life and symptom severity in patients with allergic rhinitis.
Topics: Adult; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Quality of Life; Rhinitis, Allergic, Seasonal; Surveys and Questionnaires | 2007 |
Premedication with montelukast reduces local reactions of allergen immunotherapy.
Topics: Acetates; Adult; Aged; Allergens; Anaphylaxis; Animals; Cyclopropanes; Desensitization, Immunologic; Double-Blind Method; Drug Therapy, Combination; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Insect Bites and Stings; Leukotriene Antagonists; Loratadine; Male; Middle Aged; Premedication; Quinolines; Sulfides; Wasp Venoms; Wasps | 2007 |
A comparison of ebastine 10 mg fast-dissolving tablet with oral desloratadine and placebo in inhibiting the cutaneous reaction to histamine in healthy adults.
Topics: Adult; Butyrophenones; Chemistry, Pharmaceutical; Dermatitis, Contact; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Loratadine; Male; Pain Measurement; Patient Acceptance of Health Care; Piperidines; Skin; Tablets; Treatment Outcome | 2007 |
Effectiveness of desloratadine 5 mg once daily in patients with symptoms of seasonal allergic rhinitis: results of a Canadian multicenter, open-label trial.
Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Anti-Allergic Agents; Canada; Child; Drug Administration Schedule; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Primary Health Care; Rhinitis, Allergic, Seasonal; Statistics, Nonparametric; Surveys and Questionnaires; Treatment Outcome | 2007 |
Rhinitis symptoms and quality of life in patients with chronic perennial rhinitis treated with desloratadine.
Topics: Adult; Chronic Disease; Endoscopy; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Prospective Studies; Quality of Life; Rhinitis, Allergic, Perennial; Severity of Illness Index; Treatment Outcome | 2007 |
Comparison of inhibition of cutaneous histamine reaction of ebastine fast-dissolving tablet (20 mg) versus desloratadine capsule (5 mg): a randomized, double-blind, double-dummy, placebo-controlled, three-period crossover study in healthy, nonatopic adult
Topics: Adolescent; Adult; Butyrophenones; Cross-Over Studies; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Loratadine; Male; Pain Measurement; Piperidines; Pruritus; Skin; Skin Tests | 2007 |
Influence of food on the oral bioavailability of rupatadine tablets in healthy volunteers: a single-dose, randomized, open-label, two-way crossover study.
Topics: Adolescent; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Cyproheptadine; Female; Food-Drug Interactions; Histamine H1 Antagonists; Humans; Loratadine; Male; Tablets | 2007 |
[The effect of desloratadine on use of rescue beta2-agonists and symptoms in patients suffering from seasonal allergic rhinitis and asthma].
Topics: Administration, Oral; Adult; Albuterol; Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Drug Administration Schedule; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Nasal Provocation Tests; Poland; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Statistics, Nonparametric; Surveys and Questionnaires; Treatment Outcome | 2005 |
Multiple-dose pharmacokinetics and safety of desloratadine in subjects with moderate hepatic impairment.
Topics: Adult; Aged; Analysis of Variance; Area Under Curve; Female; Half-Life; Histamine H1 Antagonists, Non-Sedating; Humans; Liver Diseases; Loratadine; Male; Middle Aged | 2007 |
Simultaneous determination of desloratadine and its active metabolite 3-hydroxydesloratadine in human plasma by LC/MS/MS and its application to pharmacokinetics and bioequivalence.
Topics: Administration, Oral; Chromatography, Liquid; Cross-Over Studies; Drug Stability; Humans; Loratadine; Male; Reference Standards; Sensitivity and Specificity; Tablets; Tandem Mass Spectrometry; Therapeutic Equivalency | 2007 |
Inhibition of allergen-induced wheal and flare reactions by levocetirizine and desloratadine.
Topics: Adolescent; Adult; Allergens; Cetirizine; Cholinergic Antagonists; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Piperazines; Prospective Studies; Urticaria | 2008 |
Efficacy and safety of desloratadine combined with dipyridamole in the treatment of chronic urticaria.
Topics: Administration, Oral; Adolescent; Adult; Aged; Child; Child, Preschool; Chronic Disease; Dipyridamole; Drug Therapy, Combination; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Platelet Aggregation Inhibitors; Skin Tests; Treatment Outcome; Urticaria | 2008 |
Prospective randomized non-blinded clinical trial on the use of dapsone plus antihistamine vs. antihistamine in patients with chronic idiopathic urticaria.
Topics: Adolescent; Adult; Case-Control Studies; Dapsone; Female; Folic Acid Antagonists; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Prospective Studies; Statistics, Nonparametric; Treatment Outcome; Urticaria | 2008 |
Quality of life in adults with chronic idiopathic urticaria receiving desloratadine: a randomized, double-blind, multicentre, placebo-controlled study.
Topics: Activities of Daily Living; Adult; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Outcome Assessment, Health Care; Quality of Life; Sleep; Treatment Outcome; Urticaria | 2008 |
Behavioral conditioning of antihistamine effects in patients with allergic rhinitis.
Topics: Adult; Animals; Association Learning; Basophils; Conditioning, Classical; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Intradermal Tests; Loratadine; Male; Middle Aged; Placebo Effect; Psychoneuroimmunology; Pyroglyphidae; Rhinitis, Allergic, Perennial; Smell; Taste; Treatment Outcome | 2008 |
[The investigation of efficacy and safety of Aerius to seasonal allergic rhinitis].
Topics: Adolescent; Adult; Anti-Allergic Agents; Child; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Rhinitis, Allergic, Seasonal; Treatment Outcome; Young Adult | 2008 |
[The effect of desloratadine on quality of life of patients with seasonal allergic rhinitis].
Topics: Adolescent; Adult; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Quality of Life; Rhinitis, Allergic, Seasonal; Treatment Outcome; Young Adult | 2008 |
Pharmacokinetic and safety profile of rupatadine when coadministered with azithromycin at steady-state levels: a randomized, open-label, two-way, crossover, Phase I study.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Area Under Curve; Azithromycin; Chromatography, High Pressure Liquid; Confidence Intervals; Cross-Over Studies; Cyproheptadine; Dose-Response Relationship, Drug; Drug Interactions; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Safety; Therapeutic Equivalency | 2008 |
Quality of life in patients with persistent allergic rhinitis treated with montelukast alone or in combination with levocetirizine or desloratadine.
Topics: Acetates; Adolescent; Adult; Aged; Cetirizine; Chronic Disease; Cross-Over Studies; Cyclopropanes; Double-Blind Method; Drug Interactions; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Leukotriene Antagonists; Loratadine; Male; Middle Aged; Quality of Life; Quinolines; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sulfides; Treatment Outcome | 2008 |
Comparison of the efficacy of levocetirizine 5 mg and desloratadine 5 mg in chronic idiopathic urticaria patients.
Topics: Cetirizine; Chronic Disease; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Pruritus; Quality of Life; Severity of Illness Index; Urticaria | 2009 |
Comparison of the efficacy and safety of bilastine 20 mg vs desloratadine 5 mg in seasonal allergic rhinitis patients.
Topics: Adolescent; Adult; Aged; Area Under Curve; Benzimidazoles; Child; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Loratadine; Male; Middle Aged; Piperidines; Quality of Life; Rhinitis, Allergic, Seasonal; Treatment Outcome; Young Adult | 2009 |
How to prescribe antihistamines for chronic idiopathic urticaria: desloratadine daily vs PRN and quality of life.
Topics: Adult; Chronic Disease; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Quality of Life; Urticaria | 2009 |
Single-dose desloratadine and montelukast and allergen-induced late airway responses.
Topics: Acetates; Adult; Allergens; Analysis of Variance; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Cross-Over Studies; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Eosinophils; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Leukotriene Antagonists; Loratadine; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Placebos; Quinolines; Respiratory Function Tests; Sputum; Sulfides; Treatment Outcome | 2009 |
High-dose desloratadine decreases wheal volume and improves cold provocation thresholds compared with standard-dose treatment in patients with acquired cold urticaria: a randomized, placebo-controlled, crossover study.
Topics: Adolescent; Adult; Aged; Cold Temperature; Cross-Over Studies; Double-Blind Method; Female; Histamine Antagonists; Humans; Loratadine; Male; Middle Aged; Prospective Studies; Urticaria; Young Adult | 2009 |
Effect of desloratadine on patients with allergic rhinitis and exercise-induced bronchoconstriction: a placebo controlled study.
Topics: Adolescent; Area Under Curve; Asthma, Exercise-Induced; Child; Cross-Over Studies; Double-Blind Method; Exercise Test; Female; Forced Expiratory Volume; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Placebos; Rhinitis, Allergic, Perennial; Treatment Outcome | 2009 |
Evaluation of desloratadine on conjunctival allergen challenge-induced ocular symptoms.
Topics: Administration, Oral; Adult; Aged; Conjunctivitis, Allergic; Cross-Over Studies; Dose-Response Relationship, Immunologic; Double-Blind Method; Eye Diseases; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Rhinitis, Allergic, Seasonal | 2009 |
Efficacy and safety of desloratadine/pseudoephedrine combination vs its components in seasonal allergic rhinitis.
Topics: Adolescent; Adult; Aged; Bronchodilator Agents; Child; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Nasal Obstruction; Pruritus; Pseudoephedrine; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Sneezing; Treatment Outcome | 2009 |
Suppression of histamine- and allergen-induced skin reactions: comparison of first- and second-generation antihistamines.
Topics: Adult; Allergens; Animals; Dermatophagoides pteronyssinus; Dibenzazepines; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Hydroxyzine; Imidazoles; Loratadine; Male; Middle Aged; Rhinitis, Allergic, Perennial; Skin Tests; Terfenadine; Treatment Outcome; Urticaria | 2009 |
Efficacy of desloratadine in intermittent allergic rhinitis: a GA(2)LEN study.
Topics: Adult; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Quality of Life; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Time Factors; Treatment Outcome; Young Adult | 2009 |
Desloratadine relieves nasal congestion and improves quality-of-life in persistent allergic rhinitis.
Topics: Adult; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Nasal Obstruction; Quality of Life; Rhinitis, Allergic, Perennial; Treatment Outcome; Young Adult | 2009 |
Desloratadine for the treatment of cypress pollen-induced allergic rhinitis.
Topics: Adult; Antigens, Plant; Cupressus; Disease Progression; Double-Blind Method; Female; France; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Nasal Obstruction; Pollen; Quality of Life; Rhinitis, Allergic, Seasonal; Sneezing; Treatment Outcome | 2009 |
Effect of levothyroxine treatment on clinical symptoms and serum cytokine levels in euthyroid patients with chronic idiopathic urticaria and thyroid autoimmunity.
Topics: Adolescent; Adult; Autoimmune Diseases; Chi-Square Distribution; Chronic Disease; Drug Combinations; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Hypothyroidism; Interferon-gamma; Interleukin-10; Loratadine; Male; Middle Aged; Prospective Studies; Thyroxine; Treatment Outcome; Tumor Necrosis Factor-alpha; Urticaria; Young Adult | 2010 |
The effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficult-to-treat urticaria.
Topics: Adult; Aged; Cetirizine; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Quality of Life; Urticaria; Young Adult | 2010 |
Influence of desloratadine on selected oxidative stress markers in patients between 3 and 10 years of age with allergic perennial rhinitis.
Topics: Biomarkers; Case-Control Studies; Catalase; Child; Child, Preschool; Female; Humans; Hydrogen Peroxide; Loratadine; Male; Malondialdehyde; Oxidative Stress; Rhinitis, Allergic, Perennial; Superoxide Dismutase | 2010 |
Efficacy of desloratadine in persistent allergic rhinitis - a GA²LEN study.
Topics: Adult; Disease Progression; Female; Follow-Up Studies; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Pain Measurement; Quality of Life; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Severity of Illness Index | 2010 |
A randomized, double-blind, active-controlled, parallel-group pilot study to compare the efficacy and sedative effects of desloratadine 5 mg with levocetirizine 5 mg in the treatment of chronic idiopathic urticaria.
Topics: Cetirizine; Chronic Disease; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Pilot Projects; Sleep Stages; Urticaria | 2010 |
Petasol butenoate complex (Ze 339) relieves allergic rhinitis-induced nasal obstruction more effectively than desloratadine.
Topics: Adult; Allergens; Anti-Allergic Agents; Bronchial Provocation Tests; Chemokines; Cross-Over Studies; Cytokines; Double-Blind Method; Female; Humans; Interleukin-8; Leukotriene B4; Loratadine; Male; Middle Aged; Nasal Obstruction; Plant Extracts; Pollen; Rhinitis, Allergic, Seasonal; Young Adult | 2011 |
Critical temperature threshold measurement for cold urticaria: a randomized controlled trial of H(1) -antihistamine dose escalation.
Topics: Adult; Aged; Cold Temperature; Dose-Response Relationship, Drug; Double-Blind Method; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Middle Aged; Urticaria; Young Adult | 2012 |
Prevalence of desloratadine poor metabolizer phenotype in healthy Jordanian males.
Topics: Adolescent; Adult; Area Under Curve; Chromatography, High Pressure Liquid; Histamine H1 Antagonists, Non-Sedating; Humans; Jordan; Loratadine; Male; Middle Aged; Phenotype; Tandem Mass Spectrometry; Young Adult | 2012 |
Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin.
Topics: Amines; Cross-Over Studies; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Middle Aged; Prospective Studies; Pruritus; Renal Dialysis; Uremia | 2012 |
Can on-demand non-sedating antihistamines improve urticaria symptoms? A double-blind, randomized, single-dose study.
Topics: Adult; Aged; Double-Blind Method; Drug Administration Schedule; Germany; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Middle Aged; Skin; Time Factors; Treatment Outcome; Urticaria; Young Adult | 2013 |
Comparison of effects of 5 and 10 mg oral desloratadine and levocetirizine on histamine-induced wheal and flare response in healthy volunteers.
Topics: Administration, Oral; Adult; Anti-Allergic Agents; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Healthy Volunteers; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Time Factors; Urticaria; Young Adult | 2013 |
The effects of antihistamines with varying anticholinergic properties on voluntary and involuntary movement.
Topics: Adult; Cholinergic Antagonists; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Promethazine; Reaction Time; Sleep Stages; Terfenadine; Tremor; Young Adult | 2013 |
Desloratadine-montelukast combination improves quality of life and decreases nasal obstruction in patients with perennial allergic rhinitis.
Topics: Acetates; Adult; Cyclopropanes; Drug Combinations; Female; Humans; Leukotriene Antagonists; Loratadine; Male; Middle Aged; Nasal Obstruction; Quality of Life; Quinolines; Rhinitis, Allergic, Perennial; Sulfides; Treatment Outcome; Young Adult | 2013 |
[Tropical endemic limbo-conjunctivitis (TELC) and allergic management: a preliminary study in Togolese children].
Topics: Adolescent; Anti-Allergic Agents; Child; Child, Preschool; Conjunctivitis, Allergic; Dexamethasone; Drug Therapy, Combination; Endemic Diseases; Female; Humans; Infant; Loratadine; Male; Neomycin; Pilot Projects; Togo; Tropical Climate | 2013 |
Tap water nasal irrigation in adults with seasonal allergic rhinitis: a randomized double-blind study.
Topics: Adult; Combined Modality Therapy; Double-Blind Method; Drinking Water; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Nasal Lavage; Quality of Life; Rhinitis, Allergic, Seasonal; Treatment Outcome | 2014 |
Association of FCER1A genetic polymorphisms with risk for chronic spontaneous urticaria and efficacy of nonsedating H1-antihistamines in Chinese patients.
Topics: Adult; Asian People; Benzimidazoles; China; Female; Genotyping Techniques; Histamine H1 Antagonists, Non-Sedating; Humans; Immunoglobulin E; Loratadine; Male; Middle Aged; Pharmacogenetics; Polymorphism, Single Nucleotide; Receptors, IgE; Terfenadine; Urticaria; Young Adult | 2015 |
Rupatadine is effective in the treatment of chronic spontaneous urticaria in children aged 2-11 years.
Topics: Age Factors; Child; Child, Preschool; Chronic Disease; Cyproheptadine; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Hungary; Loratadine; Male; Quality of Life; Remission Induction; South Africa; Time Factors; Treatment Outcome; Urticaria | 2016 |
[Determination of Desloratadine and Its Metabolite 3-OH Desloratadine in Human Plasma by LC-MS/MS].
Topics: Area Under Curve; Chromatography, Liquid; Cross-Over Studies; Humans; Loratadine; Male; Tablets; Tandem Mass Spectrometry; Therapeutic Equivalency | 2015 |
[Clinical evaluation of Montelukast plus Budesonide nasal spray and Desloratadine citrate disodium in treating moderate and severe persistent allergic rhinitis].
Topics: Acetates; Budesonide; Cyclopropanes; Humans; Loratadine; Nasal Sprays; Quinolines; Rhinitis, Allergic, Perennial; Sulfides; Surveys and Questionnaires | 2015 |
Comparative efficacy of bilastine, desloratadine and rupatadine in the suppression of wheal and flare response induced by intradermal histamine in healthy volunteers.
Topics: Adult; Benzimidazoles; Cross-Over Studies; Cyproheptadine; Double-Blind Method; Female; Healthy Volunteers; Histamine; Histamine Antagonists; Humans; Injections, Intradermal; Loratadine; Male; Piperidines; Skin | 2017 |
CRP relevance in clinical assessment of chronic spontaneous urticaria Tunisian patients.
Topics: Adult; Anti-Inflammatory Agents; Antioxidants; C-Reactive Protein; Catalase; Chronic Disease; Female; Glutathione Peroxidase; Glutathione Transferase; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Severity of Illness Index; Superoxide Dismutase; Tunisia; Urticaria; Young Adult | 2017 |
Clinical observation on the therapeutic effect of desloratadine citrate disodium in the treatment of chronic urticaria and changes in IL4, IL18, IL23 and IL-33 levels before and after treatment.
Topics: Adolescent; Adult; Chronic Disease; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Interleukin-18; Interleukin-23; Interleukin-33; Interleukin-4; Loratadine; Male; Middle Aged; Urticaria; Young Adult | 2017 |
Effects of Desloratadine Citrate Disodium on Serum Immune Function Indices, Inflammatory Factors and Chemokines in Patients with Chronic Urticaria.
Topics: Administration, Oral; Adult; Biomarkers; Chemokine CCL5; Chemokines; China; Cholinergic Antagonists; Chronic Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukins; Loratadine; Male; Middle Aged; Reference Values; Treatment Outcome; Urticaria | 2019 |
Brain histamine H
Topics: Adult; Brain; Cross-Over Studies; Double-Blind Method; Healthy Volunteers; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Positron-Emission Tomography; Receptors, Histamine H1; Sleepiness; Young Adult | 2019 |
Human H1 receptor (HRH1) gene polymorphism is associated with the severity of side effects after desloratadine treatment in Chinese patients with chronic spontaneous uticaria.
Topics: Adult; China; Chronic Disease; Drug-Related Side Effects and Adverse Reactions; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Polymorphism, Single Nucleotide; Receptors, Histamine H1; Severity of Illness Index; Sleepiness; Treatment Outcome; Urticaria | 2020 |
Efficacy of Desloratadine and Levocetirizine in Patients with Cedar Pollen-Induced Allergic Rhinitis: A Randomized, Double-Blind Study.
Topics: Adult; Cedrus; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Placebos; Pollen; Rhinitis, Allergic, Seasonal | 2019 |
A Randomized Study on the Bioequivalence of Desloratadine in Healthy Chinese Subjects and the Association of Different Metabolic Phenotypes With UGT2B10 and CYP2C8 Genotypes.
Topics: Administration, Oral; Adolescent; Adult; Aged; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP2C8; Female; Glucuronosyltransferase; Healthy Volunteers; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Pharmacogenomic Variants; Tablets; Therapeutic Equivalency; Young Adult | 2020 |
Clinical Efficacy of Vitamin D3 Adjuvant Therapy in Allergic Rhinitis: A Randomized Controlled Trial.
Topics: Adjuvants, Pharmaceutic; Adolescent; Adult; Cholecalciferol; Drug Therapy, Combination; Eosinophils; Female; Humans; Interleukin-4; Loratadine; Male; Middle Aged; Nasal Obstruction; Rhinitis, Allergic; Severity of Illness Index; Treatment Outcome; Young Adult | 2020 |
Desloratadine citrate combined with compound glycyrrhizin in the treatment of subacute eczema: A randomized trial.
Topics: Citrates; Citric Acid; Eczema; Glycyrrhizic Acid; Humans; Interleukin-2; Interleukin-4; Loratadine; Tumor Necrosis Factor-alpha | 2022 |
220 other study(ies) available for loratadine and desloratadine
| Article | Year |
|---|---|
Dual antagonists of platelet activating factor and histamine. 3. Synthesis, biological activity and conformational implications of substituted N-acyl-bis-arylcycloheptapiperazines.
Topics: Histamine Antagonists; Molecular Conformation; Piperazines; Platelet Activating Factor; Stereoisomerism | 1998 |
Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein.
Topics: Adenosine Triphosphate; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Line; Daunorubicin; Flow Cytometry; Histamine H1 Antagonists; Humans; Hydrolysis; Kinetics; Loratadine; Phosphates | 2001 |
Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity.
Topics: Animals; Cetirizine; Guinea Pigs; Histamine H1 Antagonists; Lipoxygenase Inhibitors; Loratadine; Models, Animal; Molecular Structure; Rats; Structure-Activity Relationship | 2004 |
Stereoselective synthesis of desloratadine derivatives as antagonist of histamine.
Topics: Animals; Guinea Pigs; Histamine H1 Antagonists, Non-Sedating; In Vitro Techniques; Loratadine; Male; Models, Molecular; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Stereoisomerism | 2010 |
Prediction and evaluation of protein farnesyltransferase inhibition by commercial drugs.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Farnesyltranstransferase; Green Fluorescent Proteins; Histamine H1 Antagonists, Non-Sedating; Ligands; Loratadine; Miconazole; Microscopy, Confocal; Molecular Structure; Pharmaceutical Preparations; Protein Interaction Mapping; Protein Prenylation; ras Proteins; Recombinant Fusion Proteins; Technology, Pharmaceutical | 2010 |
Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.
Topics: Animals; Cattle; Cell Line; Cell Line, Tumor; Chagas Disease; Drug Evaluation, Preclinical; Hepatocytes; High-Throughput Screening Assays; Humans; Image Processing, Computer-Assisted; Muscle, Skeletal; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Design and synthesis of thiourea derivatives containing a benzo[5,6]cyclohepta[1,2-b]pyridine moiety as potential antitumor and anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Biological Assay; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclization; Disease Models, Animal; Drug Design; Female; Humans; Inhibitory Concentration 50; Mice; Pyrimidines; Thiourea | 2012 |
Synthesis and biological evaluation of cyanoguanidine derivatives of loratadine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Ear Diseases; Guanidines; HT29 Cells; Humans; Loratadine; Male; MCF-7 Cells; Mice; Mice, Inbred Strains; Molecular Structure; Structure-Activity Relationship; Xylenes | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Loratadine and analogues: discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B(0)AT2.
Topics: Amino Acid Transport Systems, Neutral; Binding, Competitive; Brain; Cell Membrane; Chemistry, Pharmaceutical; Electrophysiology; Green Fluorescent Proteins; HEK293 Cells; Histamine H1 Antagonists, Non-Sedating; Humans; Inhibitory Concentration 50; Kinetics; Loratadine; Nerve Tissue Proteins; Patch-Clamp Techniques; Receptors, Histamine H1; Structure-Activity Relationship | 2014 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Late-Stage Lead Diversification Coupled with Quantitative Nuclear Magnetic Resonance Spectroscopy to Identify New Structure-Activity Relationship Vectors at Nanomole-Scale Synthesis: Application to Loratadine, a Human Histamine H
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Dogs; Drug Discovery; Histamine H1 Antagonists, Non-Sedating; Humans; Hydrogen Bonding; Inactivation, Metabolic; Loratadine; Magnetic Resonance Spectroscopy; Metalloporphyrins; Microsomes, Liver; Rabbits; Recombinant Proteins; Structure-Activity Relationship; Tandem Mass Spectrometry; Tissue Distribution | 2020 |
Pharmacokinetics of loratadine in patients with renal insufficiency.
Topics: Adult; Cyproheptadine; Female; Humans; Kidney Failure, Chronic; Loratadine; Male; Middle Aged; Piperidines; Pyridines; Renal Dialysis; Time Factors | 1990 |
Excretion of loratadine in human breast milk.
Topics: Adult; Cyproheptadine; Female; Histamine Antagonists; Humans; Loratadine; Milk, Human; Piperidines; Pyridines | 1988 |
Inhibitory activity of loratadine and descarboethoxyloratadine on expression of ICAM-1 and HLA-DR by nasal epithelial cells.
Topics: Adult; Histamine; Histamine H1 Antagonists; HLA-DR Antigens; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1; Loratadine; Middle Aged; Nasal Mucosa; Nasal Polyps; Piperidines; Pyridines; Turbinates | 1995 |
[HPLC-determination of loratadine and its active metabolite descarboethoxyloratadine in human plasma].
Topics: Chromatography, High Pressure Liquid; Humans; Loratadine; Piperidines; Pyridines; Spectrometry, Fluorescence | 1994 |
Sensitive gas-liquid chromatographic method for the determination of loratadine and its major active metabolite, descarboethoxyloratadine, in human plasma using a nitrogen-phosphorus detector.
Topics: Child; Chromatography, Gas; Female; Humans; Hydrogen-Ion Concentration; Loratadine; Male; Nitrogen; Phosphorus; Piperidines; Pyridines; Sensitivity and Specificity | 1994 |
Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6.
Topics: Anti-Bacterial Agents; Antifungal Agents; Antimalarials; Binding Sites; Biotransformation; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Histamine H1 Antagonists; Humans; In Vitro Techniques; Ketoconazole; Loratadine; Microsomes, Liver; Mixed Function Oxygenases; Models, Molecular; Oxidation-Reduction; Piperidines; Pyridines; Quinidine; Recombinant Proteins; Substrate Specificity; Troleandomycin | 1996 |
Comparative effects of loratadine and terfenadine on cardiac K+ channels.
Topics: Animals; Cation Transport Proteins; Ether-A-Go-Go Potassium Channels; Gene Expression; Guinea Pigs; Heart Ventricles; Histamine H1 Antagonists; In Vitro Techniques; Loratadine; Male; Membrane Potentials; Myocardium; Oocytes; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Wistar; Recombinant Proteins; Terfenadine; Xenopus laevis | 1997 |
Effect of descarboethoxyloratadine, the major metabolite of loratadine, on the human cardiac potassium channel Kv1.5.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Heart Ventricles; Humans; Ion Channel Gating; Kv1.5 Potassium Channel; Loratadine; Membrane Potentials; Mice; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines | 1997 |
Anticholinergic effects of desloratadine, the major metabolite of loratadine, in rabbit and guinea-pig iris smooth muscle.
Topics: Animals; Cholinergic Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Female; In Vitro Techniques; Iris; Loratadine; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Mydriasis; Rabbits; Time Factors | 1999 |
Preclinical pharmacology of desloratadine, a selective and nonsedating histamine H1 receptor antagonist. 1st communication: receptor selectivity, antihistaminic activity, and antiallergenic effects.
Topics: Animals; Anti-Allergic Agents; Brain; Bronchial Spasm; Edema; Female; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Humans; In Vitro Techniques; Loratadine; Lung; Macaca fascicularis; Male; Mice; Muscarinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Histamine H1 | 2000 |
The potential of active metabolites of antihistamines in the management of allergic disease.
Topics: Anti-Inflammatory Agents; Butyrophenones; Cells, Cultured; Cetirizine; Chymases; Eosinophils; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Cell Growth Factors; Histamine; Histamine H1 Antagonists; Humans; Hypersensitivity; Intercellular Adhesion Molecule-1; Interleukin-3; Interleukin-8; Loratadine; Mast Cells; Piperidines; Potassium Channel Blockers; Potassium Channels; Prostaglandin D2; Pyridines; Recombinant Fusion Proteins; Recombinant Proteins; Serine Endopeptidases; Terfenadine; Time Factors; Tryptases | 2000 |
Preclinical pharmacology of desloratadine, a selective and nonsedating histamine H1 receptor antagonist. 2nd communication: lack of central nervous system and cardiovascular effects.
Topics: Animals; Anticonvulsants; Autonomic Nervous System; Behavior, Animal; Cardiovascular System; Central Nervous System; Digestive System; Guinea Pigs; Hemodynamics; Histamine H1 Antagonists; Kidney; Loratadine; Macaca fascicularis; Male; Mice; Rats | 2000 |
Desloratadine: A new, nonsedating, oral antihistamine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Drug Interactions; Histamine H1 Antagonists; Humans; Loratadine; Rhinitis, Allergic, Seasonal; Urticaria | 2001 |
[A new antihistamine. Inhibiting inflammation in rhinorrhea and nasal congestion].
Topics: Cholinergic Antagonists; Histamine Release; Humans; Loratadine; Rhinitis, Allergic, Seasonal | 2001 |
Desloratadine.
Topics: Asthma; Clinical Trials as Topic; Drug Interactions; Histamine H1 Antagonists; Humans; Loratadine; Rhinitis, Allergic, Seasonal; Urticaria | 2001 |
Effect of desloratadine and loratadine on rhinovirus-induced intercellular adhesion molecule 1 upregulation and promoter activation in respiratory epithelial cells.
Topics: Asthma; Bronchi; Epithelial Cells; HeLa Cells; Histamine H1 Antagonists; Humans; Intercellular Adhesion Molecule-1; Loratadine; NF-kappa B; Promoter Regions, Genetic; Respiratory Mucosa; Rhinovirus; Transcriptional Activation; Up-Regulation | 2001 |
In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Histamine H1 Antagonists; Humans; In Vitro Techniques; Loratadine; Mixed Function Oxygenases; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 2001 |
[Urticaria. Finally undisturbed sleep].
Topics: Clinical Trials as Topic; Double-Blind Method; Histamine H1 Antagonists; Humans; Loratadine; Sleep; Treatment Outcome; Urticaria | 2001 |
Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine.
Topics: Basophils; Cell Culture Techniques; Cytokines; Dose-Response Relationship, Drug; Gene Expression; Histamine H1 Antagonists; Histamine Release; Humans; Immunoglobulin E; Inflammation Mediators; Interleukin-13; Interleukin-4; Leukotriene C4; Loratadine; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensitivity and Specificity | 2001 |
[The third-generation antihistaminics. Can they prevent the tier change?].
Topics: Asthma; Bronchial Hyperreactivity; Histamine H1 Antagonists; Humans; Loratadine; Placebos; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Seasonal; Risk Factors | 2002 |
Desloratadine (Clarinex).
Topics: Administration, Oral; Adolescent; Adult; Aged; Asthma; Controlled Clinical Trials as Topic; Disorders of Excessive Somnolence; Double-Blind Method; Drug Approval; Drug Interactions; Histamine H1 Antagonists; Humans; Loratadine; Middle Aged; Rhinitis, Allergic, Seasonal; Urticaria | 2002 |
Biochemical characterization of desloratadine, a potent antagonist of the human histamine H(1) receptor.
Topics: Animals; Binding, Competitive; Calcium; CHO Cells; Cloning, Molecular; Cricetinae; DNA Primers; Female; Histamine H1 Antagonists; Humans; Kinetics; Loratadine; Oligonucleotides, Antisense; Pyrilamine; Receptors, Histamine H1 | 2002 |
A pharmacokinetic profile of desloratadine in healthy adults, including elderly.
Topics: Administration, Oral; Adult; Aged; Aging; Area Under Curve; Female; Half-Life; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged | 2002 |
[The result of neglected or erroneous treatment. Mentally handicapped by hay fever].
Topics: Cognition Disorders; Histamine H1 Antagonists; Humans; Loratadine; Rhinitis, Allergic, Seasonal | 2002 |
Investigation of an enhanced resolution triple quadrupole mass spectrometer for high-throughput liquid chromatography/tandem mass spectrometry assays.
Topics: Calibration; Chromatography, High Pressure Liquid; Loratadine; Mometasone Furoate; Pharmaceutical Preparations; Piperidines; Pregnadienediols; Pyridines; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2002 |
Decongestant effects of antihistamines: a class effect?
Topics: Controlled Clinical Trials as Topic; Histamine H1 Antagonists; Humans; Loratadine; Nasal Decongestants; Rhinitis, Allergic, Seasonal; Terfenadine | 2003 |
Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Histamine H1 Antagonists, Non-Sedating; Immunoglobulin E; Inflammation; Loratadine; Mice; Mice, Inbred BALB C; Ovalbumin; Receptors, Histamine H1; T-Lymphocytes | 2003 |
Validation of a sensitive and automated 96-well solid-phase extraction liquid chromatography-tandem mass spectrometry method for the determination of desloratadine and 3-hydroxydesloratadine in human plasma.
Topics: Automation; Calibration; Chromatography, Liquid; Humans; Loratadine; Mass Spectrometry; Reproducibility of Results; Sensitivity and Specificity | 2003 |
Assessing satisfaction with desloratadine and fexofenadine in allergy patients who report dissatisfaction with loratadine.
Topics: Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Patient Satisfaction; Rhinitis, Allergic, Seasonal; Sleep Wake Disorders; Terfenadine; Treatment Outcome | 2003 |
Severe hepatotoxicity after application of desloratadine and fluconazole.
Topics: Adult; Antifungal Agents; Chemical and Drug Induced Liver Injury; Contraindications; Drug Interactions; Drug Therapy, Combination; Female; Fever of Unknown Origin; Fluconazole; Histamine H1 Antagonists, Non-Sedating; Humans; Immunoblastic Lymphadenopathy; Loratadine; Lymphoma, T-Cell; Stem Cell Transplantation | 2003 |
[Modern antihistaminics against allergic rhinitis. Better breathing without side effects].
Topics: Clinical Trials as Topic; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Nasal Obstruction; Placebos; Rhinitis, Allergic, Perennial | 2003 |
High-performance liquid chromatographic method for the bioequivalence evaluation of desloratadine fumarate tablets in dogs.
Topics: Animals; Chromatography, High Pressure Liquid; Cross-Over Studies; Dogs; Drug Evaluation, Preclinical; Fumarates; Loratadine; Tablets; Therapeutic Equivalency | 2004 |
Assessing patient satisfaction with desloratadine after conversion from loratadine, fexofenadine, or cetirizine.
Topics: Anti-Allergic Agents; Cetirizine; Choice Behavior; Data Collection; Humans; Loratadine; Managed Care Programs; Nonprescription Drugs; Patient Satisfaction; Terfenadine; United States | 2004 |
[Older antihistaminics often act as sedatives. Hay fever gone -- reaction capacity, too].
Topics: Clinical Trials as Topic; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Placebos; Rhinitis, Allergic, Seasonal | 2003 |
Oral administration of desloratadine prior to sensitization prevents allergen-induced airway inflammation and hyper-reactivity in mice.
Topics: Administration, Oral; Allergens; Animals; Bronchial Hyperreactivity; Cells, Cultured; Female; Histamine H1 Antagonists; Hypersensitivity; Immunoglobulin E; Immunoglobulin G; Interleukin-4; Interleukin-5; Loratadine; Lung; Lymph Nodes; Mice; Mice, Inbred BALB C; Models, Animal; Ovalbumin; Spleen | 2004 |
Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine.
Topics: Bilirubin; Diclofenac; Enzyme Inhibitors; Flunitrazepam; Glucuronides; Glucuronosyltransferase; Histamine H1 Antagonists, Non-Sedating; Humans; In Vitro Techniques; Loratadine; Microsomes, Liver; Time Factors | 2004 |
Reported case of severe hepatotoxicity likely due to fluconazole and not desloratadine.
Topics: Antifungal Agents; Chemical and Drug Induced Liver Injury; Fluconazole; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine | 2004 |
[Not a minor illness. Hay fever therapy should not be left to the patient].
Topics: Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Rhinitis, Allergic, Seasonal; Self Care; Treatment Outcome | 2004 |
[Combination therapy of allergic rhinitis. So that from hay fever asthma won't come].
Topics: Anti-Allergic Agents; Asthma; Child; Drug Therapy, Combination; Glucocorticoids; Histamine H1 Antagonists; Humans; Loratadine; Mometasone Furoate; Pregnadienediols; Quality of Life; Rhinitis, Allergic, Seasonal | 2004 |
Desloratadine partially inhibits the augmented bacterial responses in the sinuses of allergic and infected mice.
Topics: Animals; Antigens, CD; Cells, Cultured; Colony Count, Microbial; Female; Flow Cytometry; Histamine H1 Antagonists, Non-Sedating; Loratadine; Male; Mice; Mice, Inbred BALB C; Paranasal Sinuses; Pneumococcal Infections; Rhinitis, Allergic, Seasonal; Sinusitis; T-Lymphocytes | 2004 |
Homology modelling and binding site mapping of the human histamine H1 receptor.
Topics: Algorithms; Amino Acid Sequence; Animals; Binding Sites; Cattle; Computer Simulation; Drug Interactions; Histamine Agonists; Histamine Antagonists; Humans; Loratadine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Pyrilamine; Receptors, Histamine H1; Rhodopsin; Sequence Homology, Amino Acid; Triprolidine | 2004 |
[Nasal obstruction on the decline. Antihistamine allows allergic patients to breathe].
Topics: Cholinergic Antagonists; Clinical Trials as Topic; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Nasal Obstruction; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 2004 |
Direct injection of 96-well organic extracts onto a hydrophilic interaction chromatography/tandem mass spectrometry system using a silica stationary phase and an aqueous/organic mobile phase.
Topics: Chromatography, Liquid; Humans; Loratadine; Omeprazole; Pharmaceutical Preparations; Piperidines; Protease Inhibitors; Pyridines; Reserpine; Spectrometry, Mass, Electrospray Ionization | 2004 |
Modern histamine H1-receptor antagonists in the unified airway.
Topics: Cetirizine; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Nasal Obstruction; Nasal Provocation Tests; Piperazines; Rhinitis, Allergic, Perennial | 2004 |
Desloratadine inhibits constitutive and histamine-stimulated nuclear factor-kappaB activity consistent with inverse agonism at the histamine H1 Receptor.
Topics: Animals; Chlorocebus aethiops; COS Cells; Histamine; Histamine Agonists; Histamine H1 Antagonists; Humans; Inhibitory Concentration 50; Loratadine; NF-kappa B; Receptors, Histamine H1 | 2004 |
Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (I(Kr)) channel.
Topics: Animals; Cation Transport Proteins; Cisapride; Dose-Response Relationship, Drug; Electrophysiologic Techniques, Cardiac; Ether-A-Go-Go Potassium Channels; Guinea Pigs; In Vitro Techniques; Loratadine; Male; Myocytes, Cardiac; Phenethylamines; Potassium Channels, Voltage-Gated; Sulfonamides; Time Factors; Torsades de Pointes | 2004 |
Inhibition of nasal polyp mast cell and eosinophil activation by desloratadine.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Hypersensitivity; Eosinophil Cationic Protein; Eosinophils; Female; Histamine H1 Antagonists, Non-Sedating; Humans; In Vitro Techniques; Inflammation Mediators; Leukotriene C4; Loratadine; Male; Mast Cells; Middle Aged; Nasal Polyps; Serine Endopeptidases; Tryptases | 2005 |
Desloratadine prevents compound 48/80-induced mast cell degranulation: visualization using a vital fluorescent dye technique.
Topics: Animals; Cell Degranulation; Cell Survival; Dose-Response Relationship, Drug; Fluorescent Dyes; Histamine H1 Antagonists, Non-Sedating; Loratadine; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Peritoneal Cavity; Rats; Rats, Sprague-Dawley; Rhodamines | 2005 |
Inhibitory effects of budesonide, desloratadine and dexamethasone on cytokine release from human mast cell line (HMC-1).
Topics: Budesonide; Cell Line; Cytokines; Dexamethasone; Humans; Loratadine; Mast Cells; Tetradecanoylphorbol Acetate | 2004 |
[Preliminary clinical study of fubiding in treatment of perennial allergic rhinitis].
Topics: Adolescent; Adult; Aged; Child; Female; Follow-Up Studies; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Rhinitis, Allergic, Perennial | 2005 |
Determination of desloratadine in drug substance and pharmaceutical preparations by liquid chromatography.
Topics: Calibration; Chromatography, Liquid; Loratadine; Pharmaceutical Preparations; Reference Standards; Reproducibility of Results; Tablets; Technology, Pharmaceutical | 2005 |
Acute cholestasis related to desloratidine.
Topics: Acute Disease; Adult; Anti-Allergic Agents; Cholestasis; Female; Humans; Loratadine; Treatment Outcome | 2005 |
[Study on determination of desloratadine in human serum and its pharmacokinetics by HPLC/MS].
Topics: Chromatography, High Pressure Liquid; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Mass Spectrometry | 2005 |
[The effect of desloratadine on the TXB2 and leukotrienes levels in the nasal lavage fluid of allergic rhinitis animal model].
Topics: Animals; Female; Guinea Pigs; Histamine H1 Antagonists, Non-Sedating; Leukotrienes; Loratadine; Male; Nasal Lavage Fluid; Rhinitis, Allergic, Perennial; Thromboxane B2 | 2005 |
Orthogonal extraction/chromatography and UPLC, two powerful new techniques for bioanalytical quantitation of desloratadine and 3-hydroxydesloratadine at 25 pg/mL.
Topics: Calibration; Chromatography, High Pressure Liquid; Histamine H1 Antagonists; Humans; Loratadine; Mass Spectrometry; Pharmaceutical Solutions; Reproducibility of Results | 2006 |
In vivo antimuscarinic actions of the third generation antihistaminergic agent, desloratadine.
Topics: Animals; Cardiovascular System; Cholinergic Antagonists; Diamines; Histamine H1 Antagonists; Loratadine; Male; Mice; Mice, Inbred ICR; Oxotremorine; Parasympatholytics; Rats; Rats, Sprague-Dawley; Salivation; Tears; Tremor | 2005 |
Acute bacterial rhinosinusitis causes hyperresponsiveness to histamine challenge in mice.
Topics: Acute Disease; Animals; Dose-Response Relationship, Drug; Histamine; Histamine H1 Antagonists, Non-Sedating; Loratadine; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nasal Mucosa; Ovalbumin; Rhinitis; Sinusitis; Stem Cells; Streptococcus pneumoniae | 2005 |
Histamine H1 receptor occupancy and pharmacodynamics of second generation H1-antihistamines.
Topics: Animals; Cetirizine; CHO Cells; Cricetinae; Cricetulus; Histamine H1 Antagonists; Humans; Loratadine; Piperazines; Predictive Value of Tests; Receptors, Histamine H1; Recombination, Genetic; Terfenadine; Urticaria | 2005 |
[Isotachophoretic determination of desloratadine in tablets and syrup].
Topics: Electrophoresis; Histamine H1 Antagonists; Loratadine; Pharmaceutical Preparations; Tablets | 2005 |
Effect of desloratadine on epithelial cell granulocyte-macrophage colony-stimulating factor secretion and eosinophil survival.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Cell Survival; Cells, Cultured; Chemokine CCL11; Chemokine CCL5; Chemokines, CC; Enzyme-Linked Immunosorbent Assay; Eosinophils; Epithelial Cells; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Histamine H1 Antagonists; Humans; Interleukin-5; Interleukin-6; Interleukin-8; Loratadine; Male; Middle Aged; Nasal Mucosa; Nasal Polyps; Statistics, Nonparametric; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A | 2006 |
Sexual dysfunction in patients with allergic rhinoconjunctivitis.
Topics: Adult; Coitus; Conjunctivitis, Allergic; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Libido; Loratadine; Male; Middle Aged; Orgasm; Penile Erection; Quality of Life; Rhinitis, Allergic, Seasonal; Sexual Dysfunction, Physiological; Surveys and Questionnaires; Treatment Outcome | 2005 |
[Effects of budesonide, desloratadine and dexamethasone on interleukine-4 release and expression from human mast cell line].
Topics: Budesonide; Cell Line; Dexamethasone; Humans; Interleukin-4; Loratadine; Mast Cells; Tetradecanoylphorbol Acetate | 2005 |
Evaluation of product switching after a state Medicaid program began covering loratadine OTC 1 year after market availability.
Topics: Cetirizine; Drug Utilization Review; Histamine H1 Antagonists, Non-Sedating; Humans; Insurance Claim Review; Insurance, Pharmaceutical Services; Loratadine; Medicaid; Nonprescription Drugs; North Carolina; Retrospective Studies | 2006 |
Impact of desloratadine and loratadine on the crosstalk between human keratinocytes and leukocytes: Implications for anti-inflammatory activity of antihistamines.
Topics: Anti-Inflammatory Agents; Cell Communication; Cell Movement; Chemokine CCL5; Chemokine CXCL10; Chemokines, CC; Chemokines, CXC; Culture Media, Conditioned; Dose-Response Relationship, Drug; Eosinophils; Histamine H1 Antagonists; Humans; Interferon-gamma; Keratinocytes; Leukocytes; Loratadine; Neutrophils; Th1 Cells; Th2 Cells | 2006 |
Form I of desloratadine, a tricyclic antihistamine.
Topics: Crystallography, X-Ray; Histamine H1 Antagonists; Hydrogen Bonding; Loratadine; Models, Molecular; Molecular Structure; Stereoisomerism | 2006 |
The relative bioavailability of loratadine administered as a chewing gum formulation in healthy volunteers.
Topics: Adsorption; Adult; Biological Availability; Chewing Gum; Cross-Over Studies; Drug Delivery Systems; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Mouth Mucosa; Saliva; Tablets | 2006 |
Effect of a Chinese herbal formula, Shi-Bi-Lin, on an experimental model of allergic rhinitis.
Topics: Animals; Anti-Allergic Agents; Disease Models, Animal; Drugs, Chinese Herbal; Eosinophils; Guinea Pigs; Histamine; Histamine H1 Antagonists, Non-Sedating; Immunoglobulin E; Immunoglobulin G; Leukotrienes; Loratadine; Nasal Lavage Fluid; Nasal Mucosa; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Ovalbumin; Rhinitis; Sneezing; Thromboxane B2 | 2006 |
Diphenhydramine vs desloratadine comparisons must consider risk-benefit ratio.
Topics: Cognition Disorders; Diphenhydramine; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Rhinitis, Allergic, Seasonal; Risk Assessment | 2006 |
Simultaneous determination of loratadine and desloratadine in pharmaceutical preparations using liquid chromatography with a microemulsion as eluent.
Topics: Chromatography, Liquid; Emulsions; Histamine H1 Antagonists, Non-Sedating; Loratadine; Molecular Structure; Pharmaceutical Preparations; Reproducibility of Results; Solvents | 2007 |
The nose - from symptoms to evidence-based medicine.
Topics: Conjunctivitis; Evidence-Based Medicine; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Nasal Polyps; Nose Diseases; Rhinitis; Skin Tests | 2007 |
Validated ion pair liquid chromatography/fluorescence detection method for assessing the variability of the loratadine metabolism occurring in bioequivalence studies.
Topics: Administration, Oral; Adolescent; Adult; Chromatography, High Pressure Liquid; Drug Stability; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Molecular Structure; Piperidines; Pyridines; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Therapeutic Equivalency | 2007 |
Disposition of desloratadine in healthy volunteers.
Topics: Adult; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male | 2007 |
Simultaneous determination of desloratadine and pseudoephedrine in human plasma using micro solid-phase extraction tips and aqueous normal-phase liquid chromatography/tandem mass spectrometry.
Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Complex Mixtures; Ephedrine; Humans; Loratadine; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Microextraction; Spectrometry, Mass, Electrospray Ionization | 2007 |
Efficacy of nasal corticosteroids alone or combined with antihistamines or montelukast in treatment of allergic rhinitis.
Topics: Acetates; Administration, Intranasal; Administration, Oral; Adolescent; Adult; Anti-Allergic Agents; Cyclopropanes; Drug Therapy, Combination; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Intradermal Tests; Leukotriene Antagonists; Loratadine; Male; Middle Aged; Mometasone Furoate; Pregnadienediols; Pulmonary Ventilation; Quality of Life; Quinolines; Rhinitis, Allergic, Seasonal; Sulfides | 2008 |
[The influence of desloratadine on course of intermittens allergic rhinitis].
Topics: Adolescent; Adult; Child; Child, Preschool; Conjunctivitis, Allergic; Disease Progression; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Nasal Decongestants; Nasal Obstruction; Rhinitis, Allergic, Seasonal; Rhinomanometry; Sneezing; Surveys and Questionnaires; Treatment Outcome | 2005 |
Development and validation of high-throughput liquid chromatography-tandem mass spectrometric method for simultaneous quantification of loratadine and desloratadine in human plasma.
Topics: Chromatography, Liquid; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2007 |
Spectrophotometric, spectrofluorometric and HPLC determination of desloratadine in dosage forms and human plasma.
Topics: Calibration; Chromatography, High Pressure Liquid; Dinitrofluorobenzene; Histamine H1 Antagonists; Humans; Hydrogen-Ion Concentration; Loratadine; Reproducibility of Results; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tablets | 2007 |
Antihistamine effects on experimental middle ear inflammatory model.
Topics: Animals; Cetirizine; Disease Models, Animal; Ear, Middle; Female; Histamine H1 Antagonists, Non-Sedating; Loratadine; Male; Mucous Membrane; Otitis Media with Effusion; Rabbits | 2008 |
Comparison of inhibition of cutaneous histamine reaction of ebastine fast-dissolving tablet [20 mg] versus desloratadine capsule [5 mg]: a randomized, double-blind, double-dummy, placebo-controlled, three-period crossover study in healthy, nonatopic adult
Topics: Butyrophenones; Histamine; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Randomized Controlled Trials as Topic; Skin Tests | 2007 |
Eosinophilic angiocentric fibrosis of the orbit.
Topics: Adult; Eosinophilic Granuloma; Female; Fibrosis; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivity; Lacrimal Apparatus Diseases; Loratadine; Magnetic Resonance Imaging; Orbital Diseases; Postoperative Care; Rhinitis; Sinusitis; Steroids; Tomography, X-Ray Computed; Visual Acuity | 2008 |
Patch tests with desloratadine at 10% induce false-positive results: test at 1%.
Topics: False Positive Reactions; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivity; Loratadine; Skin Tests | 2008 |
Oral ulcerations caused by incorrect administration of desloratadine.
Topics: Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Middle Aged; Oral Ulcer | 2009 |
Structural characterization of in vitro rat liver microsomal metabolites of antihistamine desloratadine using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange HR-LC/MS.
Topics: Animals; Chromatography, Liquid; Cyclic N-Oxides; Histamine H1 Antagonists, Non-Sedating; Liver; Loratadine; Mass Spectrometry; Microsomes; Rats; Sensitivity and Specificity | 2009 |
Acid-base equilibria and solubility of loratadine and desloratadine in water and micellar media.
Topics: Acid-Base Equilibrium; Anti-Allergic Agents; Buffers; Hydrogen-Ion Concentration; Loratadine; Micelles; Molecular Structure; Solubility; Spectrophotometry; Surface-Active Agents; Water | 2009 |
Simultaneous determination of rupatadine and its metabolite desloratadine in human plasma by a sensitive LC-MS/MS method: application to the pharmacokinetic study in healthy Chinese volunteers.
Topics: Adult; Asian People; Calibration; Chromatography, Liquid; Cyproheptadine; Drug Stability; Female; Formates; Freezing; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Methanol; Molecular Structure; Platelet Activating Factor; Quality Control; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tablets; Tandem Mass Spectrometry; Time Factors; Water; Young Adult | 2009 |
Unsuspected polymorphic metabolism of rupatadine via its primary metabolite, desloratadine.
Topics: Cyproheptadine; Cytochrome P-450 CYP3A; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Mutation; Polymorphism, Single Nucleotide | 2009 |
Examining the tolerability of the non-sedating antihistamine desloratadine: a prescription-event monitoring study in England.
Topics: Adult; Cohort Studies; Drug Prescriptions; Drug Utilization; England; Female; Headache; Histamine H1 Antagonists; Humans; Loratadine; Male; Physicians, Family; Pregnancy; Urinary Tract Infections | 2009 |
The basophil activation test in the diagnosis of allergy: technical issues and critical factors.
Topics: Animals; Antibodies, Anti-Idiotypic; Antigens, CD; Basophils; Bee Venoms; Dimethindene; Histamine H1 Antagonists; Humans; Hymenoptera; Hypersensitivity; Immunologic Tests; Interleukin-3; Loratadine; Platelet Membrane Glycoproteins; Tetraspanin 30; Wasp Venoms | 2009 |
Verapamil, but not probenecid, co-administration can convert desloratadine to a sedating antihistamine in mice.
Topics: Animals; Ataxia; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Chromatography, Liquid; Drug Interactions; Histamine H1 Antagonists, Non-Sedating; Loratadine; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Probenecid; Tissue Distribution; Verapamil | 2007 |
Safety and efficacy of desloratadine in chronic idiopathic urticaria in clinical practice: an observational study of 9246 patients.
Topics: Activities of Daily Living; Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Chronic Disease; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Sleep; Urticaria; Young Adult | 2009 |
Desloratadine inhibits human skin mast cell activation and histamine release.
Topics: Histamine H1 Antagonists, Non-Sedating; Histamine Release; Humans; Loratadine; Mast Cells; Skin | 2009 |
Parental attitudes toward new dosage forms of desloratadine in an online survey: results from four European countries.
Topics: Administration, Oral; Adult; Child; Dosage Forms; Europe; Female; Health Care Surveys; Histamine H1 Antagonists, Non-Sedating; Humans; Internet; Loratadine; Male; Parents; Sucrose | 2009 |
Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel antihistamine SUN-1334H.
Topics: Acetates; Alcohols; Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ataxia; Cetirizine; Drug Interactions; Female; Guinea Pigs; Histamine H1 Antagonists, Non-Sedating; Hydroxyzine; Hypersensitivity; Immunoglobulin G; Interleukin-4; Leukocytes; Loratadine; Male; Mice; Mice, Inbred BALB C; Nasal Lavage Fluid; Nasal Mucosa; Pentobarbital; Piperazines; Sneezing; Terfenadine | 2010 |
Metabolism of loratadine and further characterization of its in vitro metabolites.
Topics: Administration, Oral; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Histamine H1 Antagonists, Non-Sedating; Humans; Hydroxylation; Isoenzymes; Ketoconazole; Liver; Loratadine; Microsomes, Liver; Recombinant Proteins; Tablets; Tandem Mass Spectrometry | 2009 |
Rapid separation of desloratadine and related compounds in solid pharmaceutical formulation using gradient ion-pair chromatography.
Topics: Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Stability; Histamine H1 Antagonists, Non-Sedating; Hydrogen-Ion Concentration; Loratadine; Solvents; Tablets; Temperature | 2010 |
A validated stability-indicating UPLC method for desloratadine and its impurities in pharmaceutical dosage forms.
Topics: Chemistry, Pharmaceutical; Chromatography, Liquid; Dosage Forms; Drug Contamination; Drug Stability; Loratadine; Pharmaceutical Solutions | 2010 |
Mast cell stabilizing properties of antihistamines.
Topics: Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Mast Cells; Skin Diseases | 2009 |
Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast.
Topics: Acetates; Administration, Oral; Adult; Anti-Allergic Agents; Anti-Asthmatic Agents; Astemizole; Cetirizine; Child; Cyclopropanes; Drug Administration Schedule; Drug Interactions; Histamine H1 Antagonists, Non-Sedating; Humans; Ketotifen; Leukotriene Antagonists; Loratadine; Piperazines; Quinolines; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Safety; Sulfides; Tablets; Terfenadine; Treatment Outcome | 2009 |
LC-MS-ESI for the determination of loratadine and descarboethoxyloratadine in human plasma.
Topics: Chromatography, Liquid; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Piperidines; Pyridines; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tablets; Tandem Mass Spectrometry; Therapeutic Equivalency; Time Factors | 2010 |
Airborne allergy to isophoronediamine and epoxy resin.
Topics: Anti-Allergic Agents; Cyclohexylamines; Dermatitis, Atopic; Dermatitis, Occupational; Epoxy Resins; Humans; Loratadine; Male; Middle Aged; Mometasone Furoate; Pregnadienediols | 2010 |
The cost-effectiveness of treatment with desloratadine in patients with persistent allergic rhinitis.
Topics: Adolescent; Cost-Benefit Analysis; Female; France; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Seasonal; Surveys and Questionnaires; Young Adult | 2010 |
CD203c-based basophil activation test in allergy diagnosis: characteristics and differences to CD63 upregulation.
Topics: Adult; Anti-Allergic Agents; Antigens, CD; Arthropod Venoms; Basophil Degranulation Test; Basophils; Bridged Bicyclo Compounds, Heterocyclic; Cell Degranulation; Cytochalasin B; Dimethindene; Female; Humans; Hypersensitivity; Immunoglobulin E; Interleukin-3; Loratadine; Male; Middle Aged; Phosphoric Diester Hydrolases; Platelet Membrane Glycoproteins; Pyrophosphatases; Tetraspanin 30; Thiazolidines; Up-Regulation | 2010 |
[Omalizumab for therapy-resistant chronic urticaria with angioedema].
Topics: Adult; Angioedema; Anti-Allergic Agents; Anti-Inflammatory Agents; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Chronic Disease; Dose-Response Relationship, Drug; Drug Resistance; Drug Therapy, Combination; Histamine H1 Antagonists, Non-Sedating; Humans; Immunoglobulin E; Leukocytosis; Loratadine; Male; Omalizumab; Prednisolone | 2010 |
Aquagenic urticaria in 2 adolescents.
Topics: Adolescent; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Urticaria; Water | 2010 |
Effects of antihistamines on innate immune responses to severe bacterial infection in mice.
Topics: Animals; Anti-Allergic Agents; Bacterial Infections; Diphenhydramine; Histamine Antagonists; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Histamine H3 Antagonists; Humans; Immunity, Innate; Loratadine; Mice; Mice, Inbred C57BL; Peritonitis; Piperidines; Receptors, Histamine; Sepsis | 2011 |
Mometasone and desloratadine additive effect on eosinophil survival and cytokine secretion from epithelial cells.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Cell Survival; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Eosinophils; Epithelial Cells; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Intercellular Adhesion Molecule-1; Interleukin-6; Interleukin-8; Loratadine; Male; Middle Aged; Mometasone Furoate; Nasal Mucosa; Nasal Polyps; Paracrine Communication; Pregnadienediols; Time Factors | 2011 |
Positive basophil activation test result in a patient with acute urticaria induced by cetirizine and desloratadine.
Topics: Adult; Basophils; Cetirizine; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Urticaria | 2011 |
Chronic idiopathic urticaria in Taiwan: a clinical study of demographics, aggravating factors, laboratory findings, serum autoreactivity and treatment response.
Topics: Adolescent; Adult; Cetirizine; Chronic Disease; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Taiwan; Treatment Outcome; Urticaria; Young Adult | 2011 |
Mastocytic enterocolitis as a rare cause of chronic diarrhea in a patient with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Biopsy; Chronic Disease; Diagnosis, Differential; Diarrhea; Drug Therapy, Combination; Enterocolitis; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Immunoglobulin E; Intestinal Mucosa; Loratadine; Male; Mast Cells; Mastocytosis; Methotrexate; Middle Aged; Ranitidine; Tryptases | 2011 |
In with the new: the determinants of prescribing innovation by general practitioners in Ireland.
Topics: Age Factors; Androstenes; Citalopram; Drug Prescriptions; Drug Utilization; Ethinyl Estradiol; General Practitioners; Humans; Information Dissemination; Insurance Claim Review; Ireland; Lactones; Loratadine; Nicotine; Omeprazole; Practice Patterns, Physicians'; Residence Characteristics; Sulfones; Therapies, Investigational; Time Factors | 2012 |
Combination treatment of mice with CRx-153 (nortriptyline and desloratadine) decreases the severity of experimental autoimmune encephalomyelitis.
Topics: Animals; Central Nervous System; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Female; Immunosuppressive Agents; Interleukin-4; Loratadine; Mice; Mice, Transgenic; Myelin Proteolipid Protein; Nortriptyline; Peptide Fragments; T-Lymphocytes | 2011 |
Mrp2 is involved in the efflux and disposition of fosinopril.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; ATP-Binding Cassette Transporters; Biological Transport, Active; Cell Line; Cell Survival; Dogs; Drug Interactions; Folic Acid Antagonists; Fosinopril; Histamine H1 Antagonists; Humans; Loratadine; Methotrexate; Mice; Mice, Knockout; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Tissue Distribution | 2013 |
The impact of P-glycoprotein mediated efflux on absorption of 11 sedating and less-sedating antihistamines using Caco-2 monolayers.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cetirizine; Chromatography, High Pressure Liquid; Drug Interactions; Histamine H1 Antagonists; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Loratadine; Mass Spectrometry; Permeability; Terfenadine | 2012 |
[Facial angioedema following hyaluronic acid injection].
Topics: Angioedema; Anti-Inflammatory Agents; Dermatologic Agents; Drug Eruptions; Drug Therapy, Combination; Facial Dermatoses; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Hyaluronic Acid; Injections, Intradermal; Lidocaine; Lip Diseases; Loratadine; Middle Aged; Prednisone; Rhinitis, Allergic, Seasonal; Skin Aging; Skin Tests | 2012 |
[The role of disturbances of lipid metabolism in pathogenesis of allergic rhinitis].
Topics: Adolescent; Adult; Drug Administration Routes; Drug Therapy, Combination; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Immunologic Factors; Lipid Metabolism; Loratadine; Male; Malondialdehyde; Mucus; Nasal Mucosa; Oxidative Stress; Piperazines; Polymers; Rhinitis, Allergic, Perennial; Severity of Illness Index; Superoxide Dismutase; Treatment Outcome | 2011 |
Spray coating as a powerful technique in preparation of solid dispersions with enhanced desloratadine dissolution rate.
Topics: Drug Stability; Histamine H1 Antagonists, Non-Sedating; Loratadine; Povidone; Solubility; Spectroscopy, Fourier Transform Infrared; Technology, Pharmaceutical | 2013 |
Solubility enhancement of desloratadine by solid dispersion in poloxamers.
Topics: Calorimetry, Differential Scanning; Histamine H1 Antagonists, Non-Sedating; Loratadine; Particle Size; Poloxamer; Solubility; Spectroscopy, Fourier Transform Infrared; Surface-Active Agents; Tablets | 2012 |
The effect of desloratadine on patch test reactions in Chinese patients.
Topics: Adult; Allergens; Anti-Inflammatory Agents; Asian People; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Patch Tests | 2012 |
A compatibility study of a secondary amine active pharmaceutical ingredient with starch: identification of a novel degradant formed between desloratadine and a starch impurity using LC-MS(n) and NMR spectroscopy.
Topics: Chromatography, Liquid; Drug Contamination; Loratadine; Magnetic Resonance Spectroscopy; Starch; Tandem Mass Spectrometry | 2013 |
The antihistamines clemastine and desloratadine inhibit STAT3 and c-Myc activities and induce apoptosis in cutaneous T-cell lymphoma cell lines.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Clemastine; Cytoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histamine Antagonists; Humans; Loratadine; Lymphoma, T-Cell, Cutaneous; Proto-Oncogene Proteins c-myc; STAT3 Transcription Factor | 2013 |
[Urticaria multiforme is a variation of urticaria, which imitates erythema multiforme].
Topics: Amoxicillin; Anti-Bacterial Agents; Diagnosis, Differential; Drug Eruptions; Erythema Multiforme; Histamine H1 Antagonists, Non-Sedating; Humans; Infant; Loratadine; Male; Pneumonia; Treatment Outcome; Urticaria | 2013 |
Seizures induced by desloratadine, a second-generation antihistamine: clinical observations.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivity; Loratadine; Male | 2013 |
Computational and experimental investigation of DNA repair protein photolyase interactions with low molecular weight drugs.
Topics: Bacterial Proteins; Deoxyribodipyrimidine Photo-Lyase; Kinetics; Loratadine; Molecular Weight; Phthalazines; Piroxicam; Prednisone; Protein Binding; Surface Plasmon Resonance; Vibrio cholerae | 2013 |
Design, synthesis and biological activity evaluation of desloratadine analogues as H1 receptor antagonists.
Topics: Animals; Drug Design; Drug Stability; HEK293 Cells; Histamine H1 Antagonists; Humans; Hydrogen-Ion Concentration; Loratadine; Mice; Protein Binding | 2013 |
Spectroscopic behavior of loratadine and desloratadine in different aqueous media conditions studied by means of TD-DFT calculations.
Topics: Electrons; Loratadine; Models, Molecular; Molecular Conformation; Protons; Quantum Theory; Spectrum Analysis; Thermodynamics; Time Factors; Water | 2013 |
[Measles-Mumps-Rubella vaccination of an egg-allergic child sensitized to gelatin].
Topics: Child; Egg Hypersensitivity; Gelatin; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivity, Immediate; Immunization Schedule; Immunoglobulin E; Injections; Intradermal Tests; Loratadine; Male; Measles-Mumps-Rubella Vaccine; Premedication; Time Factors; Vaccination | 2013 |
Does desloratadine alter the serum levels of montelukast when administered in a fixed-dose combination?
Topics: Acetates; Adult; Biological Availability; Cross-Over Studies; Cyclopropanes; Drug Interactions; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Leukotriene Antagonists; Loratadine; Male; Prospective Studies; Quinolines; Sulfides; Young Adult | 2013 |
Robust analysis of the hydrophobic basic analytes loratadine and desloratadine in pharmaceutical preparations and biological fluids by sweeping-cyclodextrin-modified micellar electrokinetic chromatography.
Topics: Chromatography, Micellar Electrokinetic Capillary; Cyclodextrins; Humans; Hydrophobic and Hydrophilic Interactions; Loratadine; Pharmaceutical Preparations | 2013 |
Practical and economical implementation of online H/D exchange in LC-MS.
Topics: Animals; Chromatography, Liquid; Deuterium; Humans; Hydrogen; Lactones; Loratadine; Metabolomics; Microsomes, Liver; Online Systems; Plasma; Pravastatin; Rats; Spectrometry, Mass, Electrospray Ionization; Urinalysis | 2013 |
Optimization and evaluation of desloratadine oral strip: an innovation in paediatric medication.
Topics: Chemistry, Pharmaceutical; Child; Drug Carriers; Humans; Loratadine; Materials Testing; Microscopy, Electron, Scanning; Mouth Mucosa; Pediatrics; Plasticizers; Rhinitis, Allergic; Rhinitis, Allergic, Perennial; Spectrophotometry, Ultraviolet | 2013 |
Processes involved in sweeping as sample enrichment method in cyclodextrin-modified micellar electrokinetic chromatography of hydrophobic basic analytes.
Topics: Adsorption; beta-Cyclodextrins; Chromatography, Micellar Electrokinetic Capillary; Cyclodextrins; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Loratadine; Parabens | 2014 |
Effects of oral intake of cetirizine HCl and desloratadine molecules on the middle ear mucosa: an experimental animal study.
Topics: Administration, Oral; Animals; Cetirizine; Ear, Middle; Edema; Histamine H1 Antagonists, Non-Sedating; Hyperemia; Loratadine; Mucous Membrane; Rats; Rats, Sprague-Dawley; Tympanic Membrane | 2014 |
Synthesis and biological evaluation of substituted desloratadines as potent arginine vasopressin V2 receptor antagonists.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Biological Assay; Cell Line; Humans; Loratadine; Magnetic Resonance Spectroscopy; Molecular Structure; Rats; Receptors, Vasopressin; Structure-Activity Relationship; Vasopressins | 2014 |
Effectiveness and safety of omalizumab in a patient with chronic urticaria and hepatitis C.
Topics: Anti-Allergic Agents; Chronic Disease; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Middle Aged; Omalizumab; Urticaria | 2015 |
Flushing, fatigue, and recurrent anaphylaxis: a delayed diagnosis of mastocytosis.
Topics: Acetates; Adult; Anaphylaxis; Cyclopropanes; Delayed Diagnosis; Drug Therapy, Combination; Epinephrine; Fatigue; Flushing; Histamine Antagonists; Humans; Leukotriene Antagonists; Loratadine; Male; Mastocytosis; Quinolines; Ranitidine; Recurrence; Sulfides | 2014 |
Simultaneous determination of desloratadine and montelukast sodium using second-derivative synchronous fluorescence spectrometry enhanced by an organized medium with applications to tablets and human plasma.
Topics: Acetates; Calibration; Carboxymethylcellulose Sodium; Chemistry, Pharmaceutical; Cyclopropanes; Humans; Hydrogen-Ion Concentration; Limit of Detection; Loratadine; Quinolines; Reproducibility of Results; Sensitivity and Specificity; Solvents; Spectrometry, Fluorescence; Sulfides; Tablets | 2015 |
Validated selective spectrophotometric methods for the kinetic determination of desloratidine in tablets and in the presence of its parent drug.
Topics: Kinetics; Loratadine; Spectrophotometry; Tablets | 2014 |
Ultrafast high-resolution mass spectrometric finger pore imaging in latent finger prints.
Topics: Dermatoglyphics; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sweat | 2014 |
Onsite survey on the mechanism of passive aeration and air flow path in a semi-aerobic landfill.
Topics: Aerobiosis; Air Movements; Air Pollutants; Environmental Monitoring; Japan; Loratadine; Temperature; Waste Disposal Facilities; Water Pollutants, Chemical | 2015 |
Influence of component 5a receptor 1 (C5AR1) -1330T/G polymorphism on nonsedating H1-antihistamines therapy in Chinese patients with chronic spontaneous urticaria.
Topics: Adolescent; Adult; Aged; Asian People; Benzimidazoles; Case-Control Studies; China; Chronic Disease; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Polymorphism, Single Nucleotide; Prospective Studies; Receptor, Anaphylatoxin C5a; Risk Factors; Treatment Outcome; Urticaria; Young Adult | 2014 |
A novel model of IgE-mediated passive pulmonary anaphylaxis in rats.
Topics: Aminopyridines; Anaphylaxis; Animals; Anti-Asthmatic Agents; Bronchoalveolar Lavage; Bronchoconstriction; Cell Degranulation; Cromolyn Sodium; Dinitrophenols; Disease Models, Animal; Histamine H1 Antagonists, Non-Sedating; Immunoglobulin E; Intracellular Signaling Peptides and Proteins; Loratadine; Lung; Mast Cells; Morpholines; Oxazines; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Rats; Rats, Wistar; Serum Albumin, Bovine; Syk Kinase | 2014 |
A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Cells, Cultured; Cryopreservation; Cytochrome P-450 CYP2C8; Dogs; Enzyme Inhibitors; Glucuronides; Glucuronosyltransferase; Haplorhini; Hepatocytes; Humans; Loratadine; Mice; Microsomes, Liver; Rabbits; Rats; Recombinant Proteins; Species Specificity; Swine; Swine, Miniature | 2015 |
Anti-allergic and anti-inflammatory properties of a potent histamine H1 receptor antagonist, desloratadine citrate disodium injection, and its anti-inflammatory mechanism on EA.hy926 endothelial cells.
Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Capillary Permeability; Cell Survival; Chlorpheniramine; Edema; Endothelial Cells; Guinea Pigs; Histamine; Histamine H1 Antagonists; Humans; Inflammation Mediators; Loratadine; Male; Mice; Nasal Mucosa; Passive Cutaneous Anaphylaxis; Rats; Rhinitis | 2015 |
Treatment of solar urticaria using antihistamine and leukotriene receptor antagonist combinations tailored to disease severity.
Topics: Acetates; Adolescent; Adult; Cetirizine; Child; Child, Preschool; Cyclopropanes; Drug Therapy, Combination; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Leukotriene Antagonists; Loratadine; Male; Middle Aged; Photosensitivity Disorders; Quinolines; Remission Induction; Remission, Spontaneous; Severity of Illness Index; Sulfides; Sunlight; Terfenadine; Ultraviolet Rays; Urticaria; Young Adult | 2015 |
Further Characterization of the Metabolism of Desloratadine and Its Cytochrome P450 and UDP-glucuronosyltransferase Inhibition Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor.
Topics: Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Glucuronosyltransferase; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Microsomes, Liver | 2015 |
Effects of desloratadine citrate disodium injection on rat models of ovalbumin-induced allergic rhinitis: involvement of T-cell responses modulation.
Topics: Allergens; Animals; Cell Adhesion Molecules; Citrates; Cytokines; Disease Models, Animal; Gene Expression Regulation; Histamine Antagonists; Humans; Immunomodulation; Loratadine; Nitric Oxide Synthase Type II; Ovalbumin; Rats; Rhinitis, Allergic; Sodium Citrate; T-Lymphocytes; Th1-Th2 Balance | 2015 |
Effects of allergic rhinitis and desloratadine on the submandibular gland in a rat allergy model.
Topics: Animals; Disease Models, Animal; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Rhinitis, Allergic; Submandibular Gland; Xerostomia | 2015 |
Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Histamine H1 Antagonists, Non-Sedating; Humans; Isoenzymes; Loratadine; Macaca fascicularis; Molecular Structure; Oxidation-Reduction; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Tandem Mass Spectrometry; Xenobiotics | 2015 |
Two Young Children with Rashes on Their Trunk and Extremities.
Topics: Diagnosis, Differential; Exanthema; Extremities; Histamine H1 Antagonists, Non-Sedating; Humans; Infant; Loratadine; Torso; Urticaria | 2015 |
Prevalence of Desloratadine Slow-metabolizer Phenotype and Food-dependent Pharmacokinetics of Desloratadine in Healthy Chinese Volunteers.
Topics: Adolescent; Adult; Area Under Curve; Asian People; Cross-Over Studies; Diet, High-Fat; Dietary Fats; Fasting; Food-Drug Interactions; Healthy Volunteers; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Phenotype; Prevalence; Young Adult | 2015 |
Desloratadine citrate disodium injection, a potent histamine H(1) receptor antagonist, inhibits chemokine production in ovalbumin-induced allergic rhinitis guinea pig model and histamine-induced human nasal epithelial cells via inhibiting the ERK1/2 and N
Topics: Animals; Anti-Allergic Agents; Cells, Cultured; Chemokine CCL2; Chemokine CCL5; Chemokines; Disease Models, Animal; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Guinea Pigs; Histamine; Histamine H1 Antagonists; Humans; Injections; Interleukin-8; Loratadine; Nasal Lavage Fluid; Nasal Mucosa; NF-kappa B; Ovalbumin; Rhinitis, Allergic; Signal Transduction | 2015 |
Human UDP-Glucuronosyltransferase (UGT) 2B10: Validation of Cotinine as a Selective Probe Substrate, Inhibition by UGT Enzyme-Selective Inhibitors and Antidepressant and Antipsychotic Drugs, and Structural Determinants of Enzyme Inhibition.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Cell Line; Cotinine; Drug Interactions; Enzyme Inhibitors; Fluconazole; Glucuronosyltransferase; HEK293 Cells; Humans; Kinetics; Loratadine; Microsomes, Liver | 2016 |
Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice.
Topics: Anemia; Animals; Benserazide; Drug Evaluation, Preclinical; Erythroid Precursor Cells; Fetal Hemoglobin; gamma-Globins; High-Throughput Screening Assays; Loratadine; Mice; Mice, Transgenic; Papio; RNA, Messenger; Transcriptional Activation | 2015 |
EDITORIAL.
Topics: Animals; Carcinogenesis; Chronic Disease; Diagnosis, Differential; Histamine Antagonists; Humans; Loratadine; Nasal Lavage; Nasal Mucosa; Nose Neoplasms; Papilloma, Inverted; Publishing; Rhinitis, Allergic; Sinusitis; Th1-Th2 Balance | 2015 |
Carbopol®-crospovidone interpolymer complex for pH-dependent desloratadine release.
Topics: Acrylic Resins; Drug Carriers; Hydrogen Bonding; Hydrogen-Ion Concentration; Loratadine; Polymers; Povidone; Solubility | 2016 |
The role of endothelin-1 and endothelin receptor antagonists in allergic rhinitis inflammation: ovalbumin-induced rat model.
Topics: Animals; Bosentan; Disease Models, Animal; Down-Regulation; Endothelin Receptor Antagonists; Endothelin-1; Female; Immunoglobulin E; Loratadine; Ovalbumin; Rats, Sprague-Dawley; Rhinitis, Allergic; RNA, Messenger; Sulfonamides; Tumor Necrosis Factor-alpha | 2016 |
BRET-based β-arrestin2 recruitment to the histamine H1 receptor for investigating antihistamine binding kinetics.
Topics: beta-Arrestin 2; Binding, Competitive; Bioluminescence Resonance Energy Transfer Techniques; Cetirizine; Dose-Response Relationship, Drug; HEK293 Cells; Histamine; Histamine Agonists; Histamine H1 Antagonists, Non-Sedating; Humans; Kinetics; Ligands; Loratadine; Luciferases, Firefly; Models, Biological; NFATC Transcription Factors; Promoter Regions, Genetic; Protein Binding; Radioligand Assay; Receptors, Histamine H1; Recombinant Fusion Proteins | 2016 |
Follicular Traction Urticaria: A New Form of Chronic Inducible Urticaria?
Topics: Administration, Oral; Biopsy; Chronic Disease; Drug Administration Schedule; Female; Hair Follicle; Hair Removal; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Physical Stimulation; Risk Factors; Tablets; Terminology as Topic; Treatment Outcome; Urticaria; Young Adult | 2017 |
Association of ORAI1 gene polymorphisms with chronic spontaneous urticaria and the efficacy of the nonsedating H1 antihistamine desloratadine.
Topics: Adult; Chronic Disease; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; ORAI1 Protein; Polymorphism, Single Nucleotide; Urticaria | 2017 |
Shiitake dermatitis.
Topics: Administration, Cutaneous; Adult; Anti-Inflammatory Agents; Betamethasone; Dermatitis; Histamine Antagonists; Humans; Loratadine; Male; Raw Foods; Shiitake Mushrooms | 2017 |
A cell-based assay using HepaRG cells for predicting drug-induced phospholipidosis.
Topics: Amikacin; Amiodarone; Amitriptyline; Biological Assay; Chlorpromazine; Female; Hep G2 Cells; Humans; Imipramine; Lipidoses; Loratadine; Phospholipids; Predictive Value of Tests; Triazoles | 2017 |
Improving mechanical properties of desloratadine via multicomponent crystal formation.
Topics: Benzoic Acid; Crystallization; Drug Compounding; Elasticity; Histamine H1 Antagonists, Non-Sedating; Hydrogen Bonding; Loratadine; Models, Chemical; Molecular Structure; Solubility; Tablets; Tensile Strength | 2018 |
Predictive Performance of Physiologically Based Pharmacokinetic (PBPK) Modeling of Drugs Extensively Metabolized by Major Cytochrome P450s in Children.
Topics: Acetates; Analgesics, Opioid; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Bronchodilator Agents; Child; Child, Preschool; Cyclopropanes; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diclofenac; Esomeprazole; Histamine H1 Antagonists, Non-Sedating; Humans; Infant; Infant, Newborn; Itraconazole; Lansoprazole; Loratadine; Models, Biological; Ondansetron; Pharmaceutical Preparations; Pharmacokinetics; Proton Pump Inhibitors; Quinolines; Serotonin Antagonists; Sufentanil; Sulfides; Theophylline; Tramadol | 2018 |
Drug interaction at hERG channel: In vitro assessment of the electrophysiological consequences of drug combinations and comparison against theoretical models.
Topics: Arrhythmias, Cardiac; Drug Combinations; Drug Interactions; Electrophysiology; ERG1 Potassium Channel; HEK293 Cells; Humans; In Vitro Techniques; Ketoconazole; Loratadine; Models, Theoretical; Patch-Clamp Techniques | 2018 |
Repurposing cationic amphiphilic drugs as adjuvants to induce lysosomal siRNA escape in nanogel transfected cells.
Topics: Adjuvants, Pharmaceutic; Carvedilol; Cell Cycle Proteins; Cell Line, Tumor; Dextrans; Fluorescein-5-isothiocyanate; Gels; Green Fluorescent Proteins; Humans; Loratadine; Lysosomes; Nanoparticles; Nortriptyline; Oligonucleotides; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; RNA, Small Interfering; Salmeterol Xinafoate; Transfection | 2018 |
Salt-dependent aquagenic urticaria in children: Report of two cases.
Topics: Child; Chronic Inducible Urticaria; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Skin Tests; Sodium Chloride; Urticaria | 2018 |
The treatment outcomes and dose de-escalation of desloratadine up-dosing in chronic spontaneous urticaria.
Topics: Adult; Chronic Disease; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Maintenance Chemotherapy; Male; Middle Aged; Recurrence; Remission Induction; Retreatment; Retrospective Studies; Treatment Outcome; Urticaria; Young Adult | 2018 |
[Allergic rhinitis management:environment control and patient education].
Topics: Administration, Intranasal; Administration, Oral; Anti-Allergic Agents; Bifidobacterium; Clostridium; Histamine H1 Antagonists, Non-Sedating; Humans; Interleukin-10; Loratadine; Mometasone Furoate; Nasal Mucosa; Quality of Life; Rhinitis, Allergic; Tablets; Transforming Growth Factor beta1; Treatment Outcome | 2017 |
Desloratadine and depression, a drug safety signal based on worldwide spontaneous reporting of side effects.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Blood-Brain Barrier; Depression; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Loratadine; Male; Middle Aged; Netherlands; Patient Safety; Pharmacovigilance; Sweden; Time Factors; Young Adult | 2018 |
The ameliorative effect of berberine and coenzyme Q10 in an ovalbumin-induced allergic rhinitis model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Berberine; Disease Models, Animal; Histamine H1 Antagonists, Non-Sedating; Immunoglobulin E; Interleukin-13; Interleukin-4; Loratadine; Malondialdehyde; Nitric Oxide; Random Allocation; Rats, Sprague-Dawley; Rhinitis, Allergic; Ubiquinone | 2018 |
[Association of CACNA1C gene genetic polymorphism with the susceptibility as well as prognosis for chronic spontaneous urticaria].
Topics: Calcium Channels, L-Type; Chronic Disease; Genetic Predisposition to Disease; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Polymorphism, Single Nucleotide; Prognosis; Retrospective Studies; Urticaria | 2018 |
Design, synthesis and bioevaluation of tricyclic fused ring system as dual binding site acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Animals; Carbazoles; Catalytic Domain; Cholinesterase Inhibitors; Drug Design; Electrophorus; Hydrogen Bonding; Loratadine; Protein Binding; Static Electricity; Torpedo | 2019 |
Prolonged intake of desloratadine: mesenteric lymphatic vessel dysfunction and development of obesity/metabolic syndrome.
Topics: Adipose Tissue; Animals; Fatty Liver; Insulin Resistance; Lipids; Loratadine; Lymphatic Vessels; Male; Metabolic Syndrome; Obesity; Rats; Rats, Sprague-Dawley; Weight Gain | 2019 |
Screening and evaluation of fungal resources for loratadine metabolites.
Topics: Aspergillus niger; Biotransformation; Chromatography, High Pressure Liquid; Cunninghamella; Fermentation; Loratadine; Magnetic Resonance Spectroscopy | 2018 |
Ecotoxic effects of loratadine and its metabolic and light-induced derivatives.
Topics: Animals; Aquatic Organisms; Crustacea; Dose-Response Relationship, Drug; Loratadine; Molecular Structure; Rotifera; Toxicity Tests, Acute; Toxicity Tests, Chronic; Ultraviolet Rays; Wastewater; Water Pollutants, Chemical | 2019 |
Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans.
Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biotransformation; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inhibitors; Drug Interactions; Female; Gemfibrozil; Genotype; Glucuronides; Humans; Hypolipidemic Agents; Loratadine; Male; Young Adult | 2019 |
C-reactive protein (CRP) rs3093059C predicts poor mizolastine response in chronic spontaneous urticaria patients with elevated serum CRP level.
Topics: Adolescent; Adult; Aged; Animals; Benzimidazoles; C-Reactive Protein; China; Chronic Disease; Chronic Urticaria; Female; Gene Expression; Genotype; HEK293 Cells; Histamine H1 Antagonists; Humans; Interleukin-6; Loratadine; Male; Middle Aged; Polymorphism, Single Nucleotide; Rats; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2019 |
A Patient with Jaundice and Pruritus, Not the Usual Suspect?
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Glucocorticoids; Glutamyl Aminopeptidase; Hepatitis, Autoimmune; Histamine H1 Antagonists, Non-Sedating; Humans; Hyperbilirubinemia; Jaundice; Loratadine; Male; Prednisolone; Pruritus; Urticaria | 2019 |
Real-life experience in the treatment of solar urticaria: retrospective cohort study.
Topics: Acetates; Adolescent; Adult; Aged; Anti-Allergic Agents; Cetirizine; Child; Cohort Studies; Cyclopropanes; Disease Management; Female; Histamine Antagonists; Humans; Leukotriene Antagonists; Loratadine; Male; Middle Aged; Omalizumab; Photosensitivity Disorders; Quinolines; Retrospective Studies; Sulfides; Terfenadine; Urticaria; Young Adult | 2019 |
Route to Prolonged Residence Time at the Histamine H
Topics: Cyproheptadine; Histamine H1 Antagonists; Humans; Kinetics; Loratadine; Molecular Docking Simulation; Protein Binding; Receptors, Histamine H1; Time Factors | 2019 |
A 6-week-old Girl with Recurrent Bullous Lesions and Erosions.
Topics: Female; Histamine H1 Antagonists, Non-Sedating; Humans; Infant; Loratadine; Mastocytosis, Cutaneous | 2019 |
Design, synthesis and biological evaluation of novel desloratadine derivatives with anti-inflammatory and H
Topics: Anti-Inflammatory Agents; Histamine H1 Antagonists; Humans; Loratadine; Structure-Activity Relationship | 2019 |
Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes.
Topics: Administration, Oral; Animals; Chimera; Glucuronides; Haplorhini; Hepatocytes; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Mice; Rats | 2020 |
Developing a High-performance Liquid Chromatography Method for Simultaneous Determination of Loratadine and its Metabolite Desloratadine in Human Plasma.
Topics: Anti-Allergic Agents; Chromatography, High Pressure Liquid; Humans; Loratadine; Reproducibility of Results | 2019 |
Biopharmaceutical classification of desloratadine - not all drugs are classified the easy way.
Topics: Animals; Biological Products; Biopharmaceutics; Caco-2 Cells; Cell Line, Tumor; Drug Compounding; Humans; Loratadine; Permeability; Solubility; Tablets | 2020 |
Carboxymethyl-botryosphaeran stabilized carbon nanotubes aqueous dispersion: A new platform design for electrochemical sensing of desloratadine.
Topics: Biosensing Techniques; Electrochemical Techniques; Electrodes; Glucans; Loratadine; Nanotubes, Carbon; Particle Size; Surface Properties; Water | 2020 |
Desloratadine inhibits heterotopic ossification by suppression of BMP2-Smad1/5/8 signaling.
Topics: Animals; Bone Morphogenetic Protein 2; Cell Differentiation; Loratadine; Male; Mice; Mice, Inbred C57BL; Ossification, Heterotopic; Osteogenesis; Receptor, Platelet-Derived Growth Factor alpha; Signal Transduction; Smad Proteins | 2021 |
Desloratadine Ameliorates Olfactory Disorder and Suppresses AMPA Receptor GluA1 Expression in Allergic Rhinitis Rat.
Topics: Animals; Disease Models, Animal; Histamine H1 Antagonists, Non-Sedating; Immunoglobulin E; Interleukins; Loratadine; Nasal Mucosa; Olfaction Disorders; Olfactory Bulb; Ovalbumin; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Rhinitis, Allergic | 2020 |
Desloratadine Use During Pregnancy and Risk of Adverse Fetal Outcomes: A Nationwide Cohort Study.
Topics: Cohort Studies; Female; Humans; Infant, Newborn; Loratadine; Pregnancy; Pregnancy Outcome; Premature Birth; Stillbirth | 2020 |
Desloratadine and loratadine use associated with improved melanoma survival.
Topics: Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Melanoma | 2020 |
A general carbonyl alkylative amination for tertiary amine synthesis.
Topics: Aldehydes; Alkylation; Amination; Amines; Chemistry Techniques, Synthetic; Loratadine | 2020 |
Mask-induced contact dermatitis in handling COVID-19 outbreak.
Topics: Anti-Inflammatory Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Dermatitis, Allergic Contact; Desonide; Facial Dermatoses; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Isocyanates; Loratadine; Masks; Pandemics; Patch Tests; Pneumonia, Viral; SARS-CoV-2; Young Adult | 2020 |
Desloratadine and loratadine stand out among common H
Topics: Breast; Breast Neoplasms; Drug Prescriptions; Female; Follow-Up Studies; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Middle Aged; Receptors, Estrogen; Registries; Risk Assessment; Risk Factors; Survival Analysis; Survival Rate; Sweden; Tumor Microenvironment | 2020 |
Molecular Origin of the Distinct Tabletability of Loratadine and Desloratadine: Role of the Bonding Area - Bonding Strength Interplay.
Topics: Administration, Oral; Crystallization; Drug Compounding; Histamine H1 Antagonists, Non-Sedating; Loratadine; Molecular Structure; Powders; Tablets | 2020 |
Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver.
Topics: Animals; Bile; Biotransformation; Carbamates; Cyproheptadine; Drug Evaluation, Preclinical; Hepatobiliary Elimination; Hepatocytes; Humans; Liver; Loratadine; Male; Mianserin; Mice; Transplantation Chimera | 2020 |
A multivariate quantification of Box-Behnken design assisted method development and validation of dextromethorphan hydrobromide and desloratadine simultaneously by reverse-phase HPLC in in-house syrup formulation.
Topics: Chromatography, High Pressure Liquid; Dextromethorphan; Drug Compounding; Equipment Design; Loratadine; Molecular Structure | 2020 |
Pharmacokinetics and Tissue Distribution of Loratadine, Desloratadine and Their Active Metabolites in Rat based on a Newly Developed LC-MS/MS Analytical Method.
Topics: Administration, Oral; Adrenal Glands; Animals; Chromatography, High Pressure Liquid; Drug Monitoring; Histamine Antagonists; Liver; Loratadine; Male; Models, Animal; Myocardium; Pituitary Gland; Rats; Spleen; Tandem Mass Spectrometry; Therapeutic Equivalency; Thymus Gland; Tissue Distribution | 2020 |
Assessing the effect of prolonged use of desloratadine on adipose Brillouin shift and composition in rats.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Histamine H1 Antagonists, Non-Sedating; Loratadine; Rats | 2021 |
Effects of oral desloratadine citrate disodium combined with physiological seawater nasal irrigation on IgE levels, IL-4, IL-6, IL-13 and IFN-γ expression and treatment of intermittent allergic rhinitis.
Topics: Adult; CD4-Positive T-Lymphocytes; Citric Acid; Female; Humans; Immunoglobulin E; Interferon-gamma; Interleukin-13; Interleukin-4; Interleukin-6; Loratadine; Male; Nasal Lavage; Rhinitis, Allergic; Seawater | 2020 |
Testing of the inhibitory effects of loratadine and desloratadine on SARS-CoV-2 spike pseudotyped virus viropexis.
Topics: Angiotensin-Converting Enzyme 2; Binding Sites; Cell Survival; COVID-19; HEK293 Cells; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Molecular Docking Simulation; Protein Binding; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Surface Plasmon Resonance; Virus Internalization | 2021 |
Antihistamines Modulate Functional Activity of Macrophages.
Topics: Animals; Cells, Cultured; Histamine Antagonists; Humans; Hypersensitivity; Loratadine; Macrophages, Peritoneal; Mice | 2021 |
[Drug-induced toxidermia in a patient receiving hydroxychloroquine as systemic therapy for primary Gougerot-Sjögren syndrome: a case report].
Topics: Adult; Antirheumatic Agents; Drug Eruptions; Female; Humans; Hydrocortisone; Hydroxychloroquine; Loratadine; Sjogren's Syndrome | 2021 |
Increasing Angiogenesis Factors in Hypoxic Diabetic Wound Conditions by siRNA Delivery: Additive Effect of LbL-Gold Nanocarriers and Desloratadine-Induced Lysosomal Escape.
Topics: Angiogenesis Inducing Agents; Animals; Cell Survival; Chemical Phenomena; Diabetic Angiopathies; Drug Compounding; Endosomes; Gene Transfer Techniques; Gold; Hypoxia; Loratadine; Lysosomes; Mice; Nanoparticles; NIH 3T3 Cells; RNA, Small Interfering | 2021 |
Desloratadine Exposure and Incidence of Seizure: A Nordic Post-authorization Safety Study Using a New-User Cohort Study Design, 2001-2015.
Topics: Adult; Child; Cohort Studies; Female; Humans; Incidence; Loratadine; Male; Research Design; Seizures | 2021 |
Simultaneous Determination of Loratadine and Its Metabolite Desloratadine in Beagle Plasma by LC-MS/MS and Application for Pharmacokinetics Study of Loratadine Tablets and Omeprazole‑Induced Drug-Drug Interaction.
Topics: Administration, Oral; Animals; Chromatography, Liquid; Dogs; Drug Interactions; Loratadine; Male; Omeprazole; Tandem Mass Spectrometry | 2021 |
Surveillance of Stability Under Different Stress Conditions in Desloratadine and Study of Degradation Kinetics.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Hydrolysis; Kinetics; Loratadine; Photolysis | 2022 |
Effective RNAi in leukemia cells is enhanced by spermine-modified pullulan combined with desloratadine.
Topics: Glucans; Humans; Leukemia; Loratadine; RNA Interference; RNA, Small Interfering; Spermine | 2022 |
UV-responsive fluorescent behavior of pharmaceuticals assessed by UV-induced fingerprint spectroscopy (UV-IFS).
Topics: Acetaminophen; Loratadine; Sildenafil Citrate; Spectrum Analysis; Tablets; Tadalafil | 2022 |