loratadine has been researched along with 3-hydroxydesloratadine in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 3 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| Beaudry, F; Clement, RP; Di Donato, L; Grandmaison, C; Kantesaria, B; Masse, R; Reyderman, L; Rudewicz, PJ; Yang, L | 1 |
| Alton, KB; Alvarez, N; Chowdhury, SK; Ghosal, A; Hapangama, N; Patrick, JE; Su, AD; Yuan, Y; Zbaida, S | 1 |
| Banfield, C; Flannery, B; Gupta, S; Herron, J; Kantesaria, B | 1 |
| Hayes, RN; Shen, JX; Tadros, S; Wang, H | 1 |
| Carbó, ML; Izquierdo, I; Merlos, M; Nadal, T; Peña, J; Solans, A | 1 |
| Chen, WL; Chu, NN; Li, XN; Xu, HR | 1 |
| Antonijoan, R; Barbanoj, M; Carbó, ML; Donado, E; Izquierdo, I; Merlos, M; Nadal, T; Peña, J; Solans, A | 1 |
| Hakooz, N; Salem, II | 1 |
| Barbara, JE; Kazmi, F; Parkinson, A; Yerino, P | 1 |
| Ding, L; Gu, P; Li, Q; Liu, B; Pan, L; Sun, C; Wu, C; Zhang, J | 1 |
| Aratyn-Schaus, Y; Ramanathan, R | 1 |
| Keerthana, M; Vidyavathi, M | 1 |
| Backman, JT; Itkonen, MK; Neuvonen, M; Neuvonen, PJ; Niemi, M; Tornio, A | 1 |
| Chacko, SA; Christopher, LJ; Gan, J; Ly, VT | 1 |
| Higuchi, Y; Suemizu, H; Uehara, S; Yamazaki, H; Yoneda, N | 1 |
| Bolleddula, J; Chowdhury, S; Kato, S; Miyata, Y; Plesescu, M; Shah, A; Zhu, X | 1 |
5 trial(s) available for loratadine and 3-hydroxydesloratadine
| Article | Year |
|---|---|
Pharmacokinetics/pharmacodynamics of desloratadine and fluoxetine in healthy volunteers.
Topics: Adolescent; Adult; Anti-Allergic Agents; Area Under Curve; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Electrocardiography; Female; Fluoxetine; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Selective Serotonin Reuptake Inhibitors | 2004 |
Influence of food on the oral bioavailability of rupatadine tablets in healthy volunteers: a single-dose, randomized, open-label, two-way crossover study.
Topics: Adolescent; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Cyproheptadine; Female; Food-Drug Interactions; Histamine H1 Antagonists; Humans; Loratadine; Male; Tablets | 2007 |
Simultaneous determination of desloratadine and its active metabolite 3-hydroxydesloratadine in human plasma by LC/MS/MS and its application to pharmacokinetics and bioequivalence.
Topics: Administration, Oral; Chromatography, Liquid; Cross-Over Studies; Drug Stability; Humans; Loratadine; Male; Reference Standards; Sensitivity and Specificity; Tablets; Tandem Mass Spectrometry; Therapeutic Equivalency | 2007 |
Pharmacokinetic and safety profile of rupatadine when coadministered with azithromycin at steady-state levels: a randomized, open-label, two-way, crossover, Phase I study.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Area Under Curve; Azithromycin; Chromatography, High Pressure Liquid; Confidence Intervals; Cross-Over Studies; Cyproheptadine; Dose-Response Relationship, Drug; Drug Interactions; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Safety; Therapeutic Equivalency | 2008 |
Prevalence of desloratadine poor metabolizer phenotype in healthy Jordanian males.
Topics: Adolescent; Adult; Area Under Curve; Chromatography, High Pressure Liquid; Histamine H1 Antagonists, Non-Sedating; Humans; Jordan; Loratadine; Male; Middle Aged; Phenotype; Tandem Mass Spectrometry; Young Adult | 2012 |
11 other study(ies) available for loratadine and 3-hydroxydesloratadine
| Article | Year |
|---|---|
Validation of a sensitive and automated 96-well solid-phase extraction liquid chromatography-tandem mass spectrometry method for the determination of desloratadine and 3-hydroxydesloratadine in human plasma.
Topics: Automation; Calibration; Chromatography, Liquid; Humans; Loratadine; Mass Spectrometry; Reproducibility of Results; Sensitivity and Specificity | 2003 |
Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine.
Topics: Bilirubin; Diclofenac; Enzyme Inhibitors; Flunitrazepam; Glucuronides; Glucuronosyltransferase; Histamine H1 Antagonists, Non-Sedating; Humans; In Vitro Techniques; Loratadine; Microsomes, Liver; Time Factors | 2004 |
Orthogonal extraction/chromatography and UPLC, two powerful new techniques for bioanalytical quantitation of desloratadine and 3-hydroxydesloratadine at 25 pg/mL.
Topics: Calibration; Chromatography, High Pressure Liquid; Histamine H1 Antagonists; Humans; Loratadine; Mass Spectrometry; Pharmaceutical Solutions; Reproducibility of Results | 2006 |
A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Cells, Cultured; Cryopreservation; Cytochrome P-450 CYP2C8; Dogs; Enzyme Inhibitors; Glucuronides; Glucuronosyltransferase; Haplorhini; Hepatocytes; Humans; Loratadine; Mice; Microsomes, Liver; Rabbits; Rats; Recombinant Proteins; Species Specificity; Swine; Swine, Miniature | 2015 |
Development of a highly sensitive LC-MS/MS method for simultaneous determination of rupatadine and its two active metabolites in human plasma: Application to a clinical pharmacokinetic study.
Topics: Chromatography, Liquid; Cyproheptadine; Female; Formates; Humans; Loratadine; Male; Plasma; Reproducibility of Results; Sensitivity and Specificity; Tablets; Tandem Mass Spectrometry | 2015 |
Advances in high-resolution MS and hepatocyte models solve a long-standing metabolism challenge: the loratadine story.
Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Coculture Techniques; Female; Glucuronides; Haplorhini; Hepatocytes; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Metabolic Networks and Pathways; Rats; Species Specificity; Tandem Mass Spectrometry | 2016 |
Screening and evaluation of fungal resources for loratadine metabolites.
Topics: Aspergillus niger; Biotransformation; Chromatography, High Pressure Liquid; Cunninghamella; Fermentation; Loratadine; Magnetic Resonance Spectroscopy | 2018 |
Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans.
Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biotransformation; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inhibitors; Drug Interactions; Female; Gemfibrozil; Genotype; Glucuronides; Humans; Hypolipidemic Agents; Loratadine; Male; Young Adult | 2019 |
Hepatocyte spheroids as a viable
Topics: Animals; Glucuronides; Hepatocytes; Humans; Loratadine; Male; Metabolic Networks and Pathways; Rats; Spheroids, Cellular | 2020 |
Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes.
Topics: Administration, Oral; Animals; Chimera; Glucuronides; Haplorhini; Hepatocytes; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Mice; Rats | 2020 |
Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver.
Topics: Animals; Bile; Biotransformation; Carbamates; Cyproheptadine; Drug Evaluation, Preclinical; Hepatobiliary Elimination; Hepatocytes; Humans; Liver; Loratadine; Male; Mianserin; Mice; Transplantation Chimera | 2020 |