loratadine and 3-hydroxydesloratadine

loratadine has been researched along with 3-hydroxydesloratadine in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (43.75)29.6817
2010's6 (37.50)24.3611
2020's3 (18.75)2.80

Authors

AuthorsStudies
Beaudry, F; Clement, RP; Di Donato, L; Grandmaison, C; Kantesaria, B; Masse, R; Reyderman, L; Rudewicz, PJ; Yang, L1
Alton, KB; Alvarez, N; Chowdhury, SK; Ghosal, A; Hapangama, N; Patrick, JE; Su, AD; Yuan, Y; Zbaida, S1
Banfield, C; Flannery, B; Gupta, S; Herron, J; Kantesaria, B1
Hayes, RN; Shen, JX; Tadros, S; Wang, H1
Carbó, ML; Izquierdo, I; Merlos, M; Nadal, T; Peña, J; Solans, A1
Chen, WL; Chu, NN; Li, XN; Xu, HR1
Antonijoan, R; Barbanoj, M; Carbó, ML; Donado, E; Izquierdo, I; Merlos, M; Nadal, T; Peña, J; Solans, A1
Hakooz, N; Salem, II1
Barbara, JE; Kazmi, F; Parkinson, A; Yerino, P1
Ding, L; Gu, P; Li, Q; Liu, B; Pan, L; Sun, C; Wu, C; Zhang, J1
Aratyn-Schaus, Y; Ramanathan, R1
Keerthana, M; Vidyavathi, M1
Backman, JT; Itkonen, MK; Neuvonen, M; Neuvonen, PJ; Niemi, M; Tornio, A1
Chacko, SA; Christopher, LJ; Gan, J; Ly, VT1
Higuchi, Y; Suemizu, H; Uehara, S; Yamazaki, H; Yoneda, N1
Bolleddula, J; Chowdhury, S; Kato, S; Miyata, Y; Plesescu, M; Shah, A; Zhu, X1

Trials

5 trial(s) available for loratadine and 3-hydroxydesloratadine

ArticleYear
Pharmacokinetics/pharmacodynamics of desloratadine and fluoxetine in healthy volunteers.
    Journal of clinical pharmacology, 2004, Volume: 44, Issue:11

    Topics: Adolescent; Adult; Anti-Allergic Agents; Area Under Curve; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Electrocardiography; Female; Fluoxetine; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Selective Serotonin Reuptake Inhibitors

2004
Influence of food on the oral bioavailability of rupatadine tablets in healthy volunteers: a single-dose, randomized, open-label, two-way crossover study.
    Clinical therapeutics, 2007, Volume: 29, Issue:5

    Topics: Adolescent; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Cyproheptadine; Female; Food-Drug Interactions; Histamine H1 Antagonists; Humans; Loratadine; Male; Tablets

2007
Simultaneous determination of desloratadine and its active metabolite 3-hydroxydesloratadine in human plasma by LC/MS/MS and its application to pharmacokinetics and bioequivalence.
    Journal of pharmaceutical and biomedical analysis, 2007, Nov-30, Volume: 45, Issue:4

    Topics: Administration, Oral; Chromatography, Liquid; Cross-Over Studies; Drug Stability; Humans; Loratadine; Male; Reference Standards; Sensitivity and Specificity; Tablets; Tandem Mass Spectrometry; Therapeutic Equivalency

2007
Pharmacokinetic and safety profile of rupatadine when coadministered with azithromycin at steady-state levels: a randomized, open-label, two-way, crossover, Phase I study.
    Clinical therapeutics, 2008, Volume: 30, Issue:9

    Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Area Under Curve; Azithromycin; Chromatography, High Pressure Liquid; Confidence Intervals; Cross-Over Studies; Cyproheptadine; Dose-Response Relationship, Drug; Drug Interactions; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Safety; Therapeutic Equivalency

2008
Prevalence of desloratadine poor metabolizer phenotype in healthy Jordanian males.
    Biopharmaceutics & drug disposition, 2012, Volume: 33, Issue:1

    Topics: Adolescent; Adult; Area Under Curve; Chromatography, High Pressure Liquid; Histamine H1 Antagonists, Non-Sedating; Humans; Jordan; Loratadine; Male; Middle Aged; Phenotype; Tandem Mass Spectrometry; Young Adult

2012

Other Studies

11 other study(ies) available for loratadine and 3-hydroxydesloratadine

ArticleYear
Validation of a sensitive and automated 96-well solid-phase extraction liquid chromatography-tandem mass spectrometry method for the determination of desloratadine and 3-hydroxydesloratadine in human plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003, Jul-25, Volume: 792, Issue:2

    Topics: Automation; Calibration; Chromatography, Liquid; Humans; Loratadine; Mass Spectrometry; Reproducibility of Results; Sensitivity and Specificity

2003
Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine.
    Biopharmaceutics & drug disposition, 2004, Volume: 25, Issue:6

    Topics: Bilirubin; Diclofenac; Enzyme Inhibitors; Flunitrazepam; Glucuronides; Glucuronosyltransferase; Histamine H1 Antagonists, Non-Sedating; Humans; In Vitro Techniques; Loratadine; Microsomes, Liver; Time Factors

2004
Orthogonal extraction/chromatography and UPLC, two powerful new techniques for bioanalytical quantitation of desloratadine and 3-hydroxydesloratadine at 25 pg/mL.
    Journal of pharmaceutical and biomedical analysis, 2006, Feb-24, Volume: 40, Issue:3

    Topics: Calibration; Chromatography, High Pressure Liquid; Histamine H1 Antagonists; Humans; Loratadine; Mass Spectrometry; Pharmaceutical Solutions; Reproducibility of Results

2006
A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement.
    Drug metabolism and disposition: the biological fate of chemicals, 2015, Volume: 43, Issue:4

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Cells, Cultured; Cryopreservation; Cytochrome P-450 CYP2C8; Dogs; Enzyme Inhibitors; Glucuronides; Glucuronosyltransferase; Haplorhini; Hepatocytes; Humans; Loratadine; Mice; Microsomes, Liver; Rabbits; Rats; Recombinant Proteins; Species Specificity; Swine; Swine, Miniature

2015
Development of a highly sensitive LC-MS/MS method for simultaneous determination of rupatadine and its two active metabolites in human plasma: Application to a clinical pharmacokinetic study.
    Journal of pharmaceutical and biomedical analysis, 2015, Volume: 111

    Topics: Chromatography, Liquid; Cyproheptadine; Female; Formates; Humans; Loratadine; Male; Plasma; Reproducibility of Results; Sensitivity and Specificity; Tablets; Tandem Mass Spectrometry

2015
Advances in high-resolution MS and hepatocyte models solve a long-standing metabolism challenge: the loratadine story.
    Bioanalysis, 2016, Volume: 8, Issue:16

    Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Coculture Techniques; Female; Glucuronides; Haplorhini; Hepatocytes; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Metabolic Networks and Pathways; Rats; Species Specificity; Tandem Mass Spectrometry

2016
Screening and evaluation of fungal resources for loratadine metabolites.
    Journal of biosciences, 2018, Volume: 43, Issue:5

    Topics: Aspergillus niger; Biotransformation; Chromatography, High Pressure Liquid; Cunninghamella; Fermentation; Loratadine; Magnetic Resonance Spectroscopy

2018
Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2019, Volume: 47, Issue:4

    Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biotransformation; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inhibitors; Drug Interactions; Female; Gemfibrozil; Genotype; Glucuronides; Humans; Hypolipidemic Agents; Loratadine; Male; Young Adult

2019
Hepatocyte spheroids as a viable
    Xenobiotica; the fate of foreign compounds in biological systems, 2020, Volume: 50, Issue:6

    Topics: Animals; Glucuronides; Hepatocytes; Humans; Loratadine; Male; Metabolic Networks and Pathways; Rats; Spheroids, Cellular

2020
Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes.
    Xenobiotica; the fate of foreign compounds in biological systems, 2020, Volume: 50, Issue:6

    Topics: Administration, Oral; Animals; Chimera; Glucuronides; Haplorhini; Hepatocytes; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Mice; Rats

2020
Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver.
    Drug metabolism and disposition: the biological fate of chemicals, 2020, Volume: 48, Issue:10

    Topics: Animals; Bile; Biotransformation; Carbamates; Cyproheptadine; Drug Evaluation, Preclinical; Hepatobiliary Elimination; Hepatocytes; Humans; Liver; Loratadine; Male; Mianserin; Mice; Transplantation Chimera

2020