loperamide and naloxone

loperamide has been researched along with naloxone in 107 studies

Research

Studies (107)

Timeframe	Studies, this research(%)	All Research%
pre-1990	37 (34.58)	18.7374
1990's	22 (20.56)	18.2507
2000's	26 (24.30)	29.6817
2010's	16 (14.95)	24.3611
2020's	6 (5.61)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Gozalbes, R; Pineda-Lucena, A	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Clay, GA; Dajani, EZ; Mackerer, CR	1
Colpaert, FC	1
Clay, GA; Lin, TK; Mackerer, CR	1
Bloss, JL; Brougham, LR; Clay, GA; Dajani, EZ; East, PF; Mackerer, CR	1
Fiasse, R; Mainguet, P; Turine, JB	1
Beubler, E; Lembeck, F	1
Fujiwara, M; Muramatsu, I; Nakashima, M; Shikimi, T	1
Piercey, MF; Ruwart, MJ	1
Sohji, Y; Suzuki, H; Yagasaki, O	1
Agmo, A; Rojas, J; Vázquez, P	1
Berggren, A; Rubenson, A; Sillén, U	2
Butt, W; Cowan, A; Fisher, RS; Krevsky, B; Maurer, AH	1
Otterson, MF; Sarna, SK	1
Badhri, P; Beubler, E	1
Petersen, KU; Wehner, F; Winterhager, JM	1
Leek, BF; Maas, CL	1
Balkovetz, DF; Ganapathy, V; Leibach, FH; Mahesh, VB; Miyamoto, Y; Tiruppathi, C	1
Burleigh, DE	1
Gautret, B; Schmitt, H	1
Bhargava, KP; Gupta, GP; Gupta, MB	1
D'Odorico, A; Martin, A; Montino, C; Naccarato, R; Sturniolo, GC	1
Jivegård, L; Svanvik, J	1
Costentin, J; Lecomte, JM; Marçais-Collado, H; Schwartz, JC; Uchida, G	1
Bueno, L; Fargeas, MJ; Fioramonti, J	1
Culver, PJ; Rattan, S	1
Basilisco, G; Bianchi, PA; Bozzani, A; Camboni, G; Paravicini, M	1
Gaginella, TS; Kachur, JF; Morgan, DW	1
Basilisco, G; Bianchi, PA; Bozzani, A; Camboni, G; Conte, D; Penagini, R; Quatrini, M; Recchia, M	1
Friedli, G; Haenggeli, CA	1
Bueno, L; Latour, A	1
Contreras, E; Germany, A; Merino, A	1
Bloom, SR; Christofides, ND; Rees, WD; Sharpe, GR; Turnberg, LA	1
Herz, A; Schulz, R; Wüster, M	1
Candy, DC; Harries, JT; Sandhu, BK; Tripp, JH	1
Giagnoni, G; Gori, E; Marabini, L; Parolaro, D; Sala, M; Senini, R	1
Milla, PJ; Phillips, AD; Sandhu, BK	1
Appia, F; Chariot, J; De La Tour, J; Roze, C; Vaille, C	1
Bastidas, O; Bermudez, EL; Ramirez, MS	1
Carr, KD; Simon, EJ	1
Higgs, NB; Hughes, S; Turnberg, LA	1
Barbieri, C; Caldara, R; Cambielli, M; Ferrari, C; Guslandi, M; Masci, E	1
Korey, A; Sellers, EM; Zilm, DH	1
Green, J; Jaffe, JH; Kanzler, M	1
Kromer, W	1
Agmo, A; Contreras, JL; Paredes, RG	1
Bartesaghi, B; Bianchi, PA; Negri, G	1
Friderichs, E; Reimann, W; Reinartz, S; Selve, N	1
Auernhammer, CJ; Lehnert, P; Müller, OA; Riepl, RL; Schopohl, J; Stalla, GK	1
Auernhammer, CJ; Müller, OA; Renner, U; Stalla, GK; Stalla, J	1
Onoda, Y; Yamada, K	1
Carroll, ME; Mattox, AJ	1
Berny, PJ; Buronfosse, F; Cadore, JL; Hugnet, C; Mathet, T; Pineau, X	1
Bolognese, A; Capasso, F; Diurno, MV; Izzo, AA; Mazzoni, O	1
Croci, T; Emonds-Alt, X; Landi, M; Le Fur, G; Maffrand, JP; Manara, L	1
Hatakeyama, Y; Ohtsuka, M; Shimomura, K; Tomoi, M	1
Bespalov, AY; Dravolina, OA; Medvedev, IO	1
Nozaki-Taguchi, N; Yaksh, TL	2
Chen, YC; Cheng, JT; Chi, TC; Liu, IM; Lu, FH	1
Barini, A; Ciampelli, M; Cinque, B; Cucinelli, F; Guido, M; Lanzone, A	1
Ikari, A; Sakai, H; Suzuki, T; Takeguchi, N	1
Epple, HJ; Fromm, M; Riecken, EO; Schulzke, JD	1
Aoki, Y; Asai, M; Iwasaki, Y; Mutsuga, N; Nomura, A; Oiso, Y; Saito, H; Yamamori, E; Yoshida, M	1
Lutz, EA; Shannon, HE	1
Besra, SE; Chaudhury, L; Ganguly, DK; Gomes, A; Vedasiromoni, JR	1
Besra, SE; Ganguly, DK; Gomes, A; Vedasiromoni, JR	1
Gillardin, JM; Girard, P; Lorette, I; Pansart, Y	1
Baamonde, A; García, E; Hidalgo, A; Lastra, A; Meana, A; Menéndez, L	1
Hagiwara, K; Iijima, T; Miyoshi, I; Murakami, M; Murata, A; Nakagawasai, O; Tadano, T; Tan-No, K; Yamadera, F; Yanagisawa, T	1
Chen, PF; Chen, WC; Cheng, JT; Liou, SS; Liu, IM	1
Chanzy, S; De Gennes, C; Mayet, H; Moretti, S; Msélati, JC; Routon, MC	1
Cook, CD; Nickerson, MD	1
Cheng, JT; Liu, IM; Tzeng, TF	1
Bertamino, A; Borrelli, F; Capasso, R; di Bosco, AM; Diurno, MV; Grieco, P; Mazzoni, O; Novellino, E	1
Cheng, JT; Liu, IM; Lo, CY; Tzeng, TF	1
Bowlby, MR; Dunlop, J; Kaftan, EJ; Lee, Y; Mayer, SC; Rogers, KE; Shan, Q; Strassle, BW; Vasilyev, DV	1
Baamonde, A; García, V; Hidalgo, A; Juárez, L; Menéndez, L	1
Andoh, T; Kuraishi, Y; Nakashima, Y; Sasaki, A; Shiraki, K; Takasaki, I	1
Horie, S; Kimura, H; Matsumoto, K; Tashima, K; Uchida, M	1
Ray, SB; Yaksh, TL	1
Christians, U; Elkiweri, IA; Henthorn, TK; Ng, KY; Tissot van Patot, MC; Zhang, YL	1
Cheng, JT; Liu, IM; Wu, HT; Yang, TT	1
Doihara, H; Ito, H; Kawabata-Shoda, E; Kojima, R; Nozawa, K; Yokoyama, T	1
Bashkatova, VG; Chumakova, YA; Proskuryakova, TV; Shokhonova, VA; Sudakov, SK	1
Sugimoto, Y; Yamamoto, A	1
Chekmareva, NY; Chumakova, YA; Kolpakov, AA; Sotnikov, SV; Sudakov, SK; Umryukhin, AE	1
Bashkatova, VG; Kolpakov, AA; Sudakov, SK; Trigub, MM	1
Chen, IH; Cheng, JT; Tong, YC; Yu, BC	1
Chen, ZC; Cheng, JT; Chung, HH; Hung, CH; Lin, HJ; Shieh, JP	1
Cheng, JT; Chung, HH; Lee, LM; Lin, CS; Lin, KC	1
Chen, W; Cheng, JT; Chung, HH	1
Carteret, AF; Chung, C; Dong, X; Guan, Y; Hartke, TV; McKelvy, AD; Raja, SN; Ringkamp, M; Yang, F	1
Fichna, J; Misicka, A; Sacharczuk, M; Wasilewski, A	1
Heller, NM; Maher, DP; Walia, D	1
White, CM	1
Garlapati, V; Koola, MM; Kumari, P; Varghese, SP; Wijegunaratne, H; Yovankin, T	1
Jones, P; Key, P; Prahlow, JA; Strzyzewski, L	1
Bögeholz, N; Burde, S; Eckardt, L; Ellermann, C; Fehr, M; Frommeyer, G; Leitz, P; Reinke, F; Willy, K; Wolfes, J	1
Levine, M; Lovecchio, F	1
Aimoto, M; Izawa, S; Nagasawa, Y; Seki, S; Takahara, A	1
Brookes, SSJ; Costa, M; Dinning, PG; Heitmann, PT; Keightley, L; Spencer, NJ; Wattchow, DA; Wiklendt, L	1
Corrêa Benedet Baesso, K; De Sá Soares, A; Schuelter-Trevisol, F; Zapelini do Nascimento, D	1

Reviews

4 review(s) available for loperamide and naloxone

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Discriminative stimulus properties of narcotic analgesic drugs. Pharmacology, biochemistry, and behavior, 1978, Volume: 9, Issue:6 Topics: Adrenocorticotropic Hormone; Analgesics, Opioid; Buprenorphine; Cues; Discrimination, Psychological; Drug Tolerance; Generalization, Psychological; Humans; Loperamide; Naloxone; Neurotransmitter Agents; Receptors, Opioid; Stereoisomerism; Substance-Related Disorders	1978
Loperamide: A Readily Available but Dangerous Opioid Substitute. Journal of clinical pharmacology, 2019, Volume: 59, Issue:9 Topics: Analgesics, Opioid; Animals; Antidiarrheals; Humans; Loperamide; Naloxone; Substance Withdrawal Syndrome; Torsades de Pointes	2019
New Designer Drugs. Emergency medicine clinics of North America, 2021, Volume: 39, Issue:3 Topics: Analgesics, Opioid; Buprenorphine; Cannabinoids; Designer Drugs; Drug Overdose; Fentanyl; Humans; Hypnotics and Sedatives; Illicit Drugs; Loperamide; Mitragyna; Naloxone; Narcotic Antagonists; Phenethylamines; Substance-Related Disorders	2021

Trials

6 trial(s) available for loperamide and naloxone

Article	Year
Long-term survey of the treatment of diarrhoea with loperamide. Digestion, 1977, Volume: 16, Issue:1-2 Topics: Adult; Chronic Disease; Clinical Trials as Topic; Diarrhea; Double-Blind Method; Drug Evaluation; Female; Humans; Isotonic Solutions; Loperamide; Male; Middle Aged; Naloxone; Piperidines; Pupil; Sodium Chloride; Time Factors	1977
Oral naloxone antagonizes loperamide-induced delay of orocecal transit. Digestive diseases and sciences, 1987, Volume: 32, Issue:8 Topics: Administration, Oral; Adult; Breath Tests; Double-Blind Method; Drug Administration Schedule; Female; Gastrointestinal Motility; Humans; Hydrogen; Lactulose; Loperamide; Male; Mouth; Naloxone; Piperidines; Random Allocation	1987
The effects of an opiate agonist and antagonist on the human upper gastrointestinal tract. European journal of clinical investigation, 1983, Volume: 13, Issue:3 Topics: Adult; Amylases; Bile Acids and Salts; Digestive System; Digestive System Physiological Phenomena; Duodenum; Endorphins; Gastric Acid; Gastrointestinal Motility; Humans; Loperamide; Motilin; Naloxone; Piperidines	1983
Abuse potential of loperamide. Clinical pharmacology and therapeutics, 1980, Volume: 28, Issue:6 Topics: Adult; Codeine; Humans; Loperamide; Male; Naloxone; Piperidines; Pupil; Substance-Related Disorders	1980
Effect of loperamide on lower oesophageal sphincter pressure in idiopathic achalasia. Scandinavian journal of gastroenterology, 1994, Volume: 29, Issue:12 Topics: Administration, Oral; Adult; Esophageal Achalasia; Esophagogastric Junction; Female; Humans; Loperamide; Male; Manometry; Middle Aged; Naloxone; Pressure; Treatment Outcome	1994
Hypothalamic-pituitary-adrenal axis sensitivity to opioids in women with polycystic ovary syndrome. Fertility and sterility, 2000, Volume: 73, Issue:4 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Body Weight; Female; Humans; Hydrocortisone; Hypothalamus; Loperamide; Naloxone; Narcotic Antagonists; Narcotics; Obesity; Pituitary Gland; Polycystic Ovary Syndrome	2000

Other Studies

97 other study(ies) available for loperamide and naloxone

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
QSAR-based solubility model for drug-like compounds. Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19 Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
Loperamide binding to opiate receptor sites of brain and myenteric plexus. The Journal of pharmacology and experimental therapeutics, 1976, Volume: 199, Issue:1 Topics: Analgesics, Opioid; Animals; Brain; Electric Stimulation; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Loperamide; Male; Morphine; Muscle Contraction; Myenteric Plexus; Naloxone; Piperidines; Reaction Time; Receptors, Opioid	1976
Interaction of loperamide with [3H]naloxone binding sites in guinea pig brain and myenteric plexus. Molecular pharmacology, 1977, Volume: 13, Issue:3 Topics: Animals; Binding Sites; Brain; Drug Interactions; Electric Stimulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; Loperamide; Male; Morphine; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Piperidines; Receptors, Opioid	1977
Antidiarrheal and central nervous system activities of SC-27166 (2-[3 - 5 - methyl - 1, 3, 4 - oxadiazol - 2 - yl) - 3, 3 - diphenylpropyl] - 2 - azabicyclo [2.2.2]octane), a new antidiarrheal agent, resulting from binding to opiate receptor sites of brai The Journal of pharmacology and experimental therapeutics, 1977, Volume: 203, Issue:3 Topics: Animals; Antidiarrheals; Brain; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Central Nervous System; Gastrointestinal Motility; Guinea Pigs; Humans; In Vitro Techniques; Loperamide; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Substance-Related Disorders	1977
Inhibition of stimulated fluid secretion in the rat small and large intestine by opiate agonists. Naunyn-Schmiedeberg's archives of pharmacology, 1979, Volume: 306, Issue:2 Topics: Animals; Bethanechol Compounds; Carbachol; Dextrorphan; Female; In Vitro Techniques; Intestinal Secretions; Intestine, Large; Intestine, Small; Levorphanol; Loperamide; Morphine; Naloxone; Narcotic Antagonists; Prostaglandins E; Rats; Vasoactive Intestinal Peptide	1979
Effects of loperamide on the guinea pig taenia coli. European journal of pharmacology, 1979, Apr-15, Volume: 55, Issue:2 Topics: Acetylcholine; Animals; Colon; Drug Interactions; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Loperamide; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Nicotine; Piperidines; Serotonin	1979
Naloxone inhibits the anti-diarrhoeal activity of loperamide. British journal of pharmacology, 1979, Volume: 66, Issue:3 Topics: Animals; Diarrhea; Loperamide; Male; Naloxone; Piperidines; Prostaglandins E; Rats	1979
Effects of loperamide on acetylcholine and prostaglandin release from isolated guinea pig ileum. Japanese journal of pharmacology, 1978, Volume: 28, Issue:6 Topics: Acetylcholine; Animals; Depression, Chemical; Guinea Pigs; Ileum; In Vitro Techniques; Intestinal Mucosa; Loperamide; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Parasympatholytics; Piperidines; Prostaglandins	1978
Inhibitory effect of opiates on male rat sexual behavior may be mediated by opiate receptors outside the central nervous system. Psychopharmacology, 1992, Volume: 107, Issue:1 Topics: Analysis of Variance; Animals; Central Nervous System; Conditioning, Psychological; Ejaculation; Loperamide; Male; Morphine; Naloxone; Oxymorphone; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Sexual Behavior, Animal	1992
In vivo motor effects of loperamide on the rat urinary bladder. Acta physiologica Scandinavica, 1992, Volume: 145, Issue:1 Topics: Acetylcholine; Animals; Drug Interactions; Electric Stimulation; Injections, Intra-Arterial; Loperamide; Male; Muscle Contraction; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Substance P; Urinary Bladder	1992
Effects of selective opioid agonists on feline colonic transit. Life sciences, 1991, Volume: 48, Issue:16 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cattle; Colon; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gastrointestinal Motility; Loperamide; Morphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1991
Small intestinal amyogenesia and dysmyogenesia induced by morphine and loperamide. The American journal of physiology, 1990, Volume: 258, Issue:2 Pt 1 Topics: Animals; Atropine; Dogs; Female; Gastrointestinal Motility; Hexamethonium; Hexamethonium Compounds; Intestine, Small; Loperamide; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Piperidines	1990
Comparison of the antisecretory effects of loperamide and loperamide oxide in the jejunum and the colon of rats in-vivo. The Journal of pharmacy and pharmacology, 1990, Volume: 42, Issue:10 Topics: Administration, Oral; Animals; Colon; Dinoprostone; Female; Intestinal Mucosa; Intubation, Gastrointestinal; Jejunum; Loperamide; Naloxone; Prodrugs; Rats; Rats, Inbred Strains	1990
Motor effects of loperamide on rat urinary bladder: an in vitro study. Pharmacology & toxicology, 1991, Volume: 68, Issue:1 Topics: Animals; Calcium; Electric Stimulation; In Vitro Techniques; Loperamide; Male; Muscle Contraction; Naloxone; Potassium; Rats; Rats, Inbred Strains; Urinary Bladder	1991
Naloxone-insensitive transport effects of loperamide in guinea-pig gallbladder epithelium. European journal of pharmacology, 1990, Mar-27, Volume: 178, Issue:3 Topics: Alprostadil; Animals; Bicarbonates; Biological Transport; Electrophysiology; Enkephalin, Methionine; Epithelium; Gallbladder; Guinea Pigs; In Vitro Techniques; Intestinal Absorption; Loperamide; Male; Naloxone; Piperidines; Receptors, Opioid; Sodium; Sodium Radioisotopes	1990
Central and local actions of opioids upon reticulo-ruminal motility in sheep. Veterinary research communications, 1985, Volume: 9, Issue:2 Topics: Animals; Bradykinin; Enkephalins; Gastrointestinal Motility; In Vitro Techniques; Loperamide; Morphine Derivatives; Muscle Contraction; Naloxone; Narcotics; Prostaglandins E; Reticulum; Rumen; Sheep; Substance P	1985
Inhibition of brush-border membrane Na+-H+ exchanger by loperamide. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:1 Topics: Amiloride; Carrier Proteins; Drug Interactions; Female; Humans; Kinetics; Loperamide; Microvilli; Naloxone; Piperidines; Placenta; Reference Values; Sodium-Hydrogen Exchangers	1987
Opioid and non-opioid actions of loperamide on cholinergic nerve function in human isolated colon. European journal of pharmacology, 1988, Jul-26, Volume: 152, Issue:1-2 Topics: Acetylcholine; Action Potentials; Calcium; Colon; Humans; In Vitro Techniques; Loperamide; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Parasympathetic Nervous System; Piperidines; Receptors, Opioid	1988
Vagally mediated reflex and cardiac slowing induced by loperamide in rats. European journal of pharmacology, 1985, Jan-02, Volume: 107, Issue:2 Topics: Animals; Atropine; Benzomorphans; Blood Pressure; Heart Rate; Loperamide; Male; Naloxone; Narcotic Antagonists; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Reflex; Vagus Nerve	1985
Role of opioid receptors in stress induced gastric ulceration in rats. The Indian journal of medical research, 1986, Volume: 83 Topics: Animals; Female; Loperamide; Male; Morphine; Naloxone; Rats; Receptors, Opioid; Stomach Ulcer; Stress, Physiological	1986
[Irritable bowel syndrome]. Giornale di clinica medica, 1988, Volume: 69, Issue:3 Topics: Adult; Antidepressive Agents; Benzodiazepines; Colonic Diseases, Functional; Dextromethorphan; Diagnosis, Differential; Humans; Loperamide; Naloxone; Parasympatholytics	1988
The influence of morphine, loperamide and naloxone on gallbladder response to prostaglandin E2 in the anaesthetized cat. Acta physiologica Scandinavica, 1986, Volume: 127, Issue:3 Topics: Animals; Cats; Cholecystitis; Dinoprostone; Female; Gallbladder; Loperamide; Male; Morphine; Muscle Contraction; Naloxone; Perfusion; Piperidines; Prostaglandins E; Water-Electrolyte Balance	1986
Naloxone-reversible antidiarrheal effects of enkephalinase inhibitors. European journal of pharmacology, 1987, Dec-01, Volume: 144, Issue:2 Topics: Amino Acids, Sulfur; Animals; Castor Oil; Diarrhea; Drug Interactions; Gastrointestinal Transit; Loperamide; Male; Metalloendopeptidases; Mice; Naloxone; Neprilysin; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin	1987
Stimulation of gastrointestinal motility by loperamide in dogs. Digestive diseases and sciences, 1987, Volume: 32, Issue:6 Topics: Administration, Oral; Animals; Colon; Dogs; Gastrointestinal Motility; Injections, Intraventricular; Injections, Subcutaneous; Jejunum; Loperamide; Muscle Contraction; Naloxone; Piperidines; Pyloric Antrum	1987
Influence of loperamide on the internal anal sphincter in the opossum. Gastroenterology, 1987, Volume: 93, Issue:1 Topics: Anal Canal; Animals; Drug Interactions; Electric Stimulation; Female; Isoproterenol; Loperamide; Male; Naloxone; Nicotine; Opossums; Piperidines; Pressure; Rectum; Spinal Nerve Roots; Verapamil	1987
Effect of dextromethorphan on guinea pig ileal contractility in vitro: comparison with levomethorphan, loperamide and codeine. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:3 Topics: Actins; Adenosine Triphosphate; Animals; Calcium; Calmodulin; Codeine; Dextromethorphan; Electric Stimulation; Ileum; Levorphanol; Loperamide; Muscle Contraction; Myosins; Naloxone; Piperidines	1986
Effect of loperamide and naloxone on mouth-to-caecum transit time evaluated by lactulose hydrogen breath test. Gut, 1985, Volume: 26, Issue:7 Topics: Adult; Breath Tests; Female; Gastrointestinal Motility; Humans; Hydrogen; Lactulose; Loperamide; Male; Naloxone; Piperidines	1985
Loperamide overdose managed by naloxone. Lancet (London, England), 1980, Jun-28, Volume: 1, Issue:8183 Topics: Central Nervous System; Diarrhea, Infantile; Female; Humans; Infant; Loperamide; Naloxone; Piperidines	1980
A micro-computerised system to measure the colonic contractile activity: application to pharmacological tests in dogs. International journal of bio-medical computing, 1980, Volume: 11, Issue:5 Topics: Animals; Atropine; Computers; Dogs; Electrophysiology; Gastrointestinal Motility; Intestines; Loperamide; Microcomputers; Morphine; Muscle Contraction; Nalorphine; Naloxone; Pyrrolidines	1980
Naloxone prevents loperamide inhibition of neurotransmitter induced contractions in rat vas deferens. Cellular and molecular biology, 1983, Volume: 29, Issue:5 Topics: Acetylcholine; Animals; Dopamine Antagonists; Loperamide; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Neurotransmitter Agents; Norepinephrine; Piperidines; Rats; Vas Deferens	1983
Inquiry into endorphinergic feedback mechanisms during the development of opiate tolerance/dependence. Brain research, 1980, May-12, Volume: 189, Issue:2 Topics: Animals; Brain; Dextrorphan; Drug Tolerance; Endorphins; Etorphine; Feedback; Humans; Levorphanol; Loperamide; Male; Naloxone; Opioid-Related Disorders; Pituitary Gland; Rats; Receptors, Opioid	1980
Loperamide: studies on its mechanism of action. Gut, 1981, Volume: 22, Issue:8 Topics: Adenylyl Cyclases; Animals; Cholera Toxin; Cyclic AMP; Dinoprostone; Intestinal Absorption; Intestinal Secretions; Jejunum; Loperamide; Male; Naloxone; Piperidines; Prostaglandins E; Rats; Rats, Inbred Strains	1981
Increase of plasma corticosterone induced by loperamide in rats. European journal of pharmacology, 1982, Apr-08, Volume: 79, Issue:1-2 Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Female; Injections, Intraperitoneal; Injections, Intraventricular; Loperamide; Naloxone; Piperidines; Rats; Rats, Inbred Strains	1982
Opiate agonists and enterotoxins. Biochemical Society transactions, 1984, Volume: 12, Issue:2 Topics: Animals; Cholera Toxin; Cyclic AMP; Diarrhea; Enkephalin, Methionine; Intestinal Mucosa; Loperamide; Male; Naloxone; Piperidines; Rats; Water-Electrolyte Balance	1984
Loperamide-induced inhibition of pancreatic secretion in rats. European journal of pharmacology, 1984, Aug-03, Volume: 103, Issue:1-2 Topics: Acetylcholine; Anesthesia; Animals; Bicarbonates; Cholecystokinin; Electric Stimulation; Glucose; Loperamide; Male; Naloxone; Pancreas; Pancreatic Fistula; Piperidines; Proteins; Rats; Rats, Inbred Strains; Vagus Nerve	1984
A suspected case of loperamide toxicity. Veterinary and human toxicology, 1983, Volume: 25, Issue:5 Topics: Humans; Infant, Newborn; Loperamide; Male; Naloxone; Piperidines	1983
The role of opioids in feeding and reward elicited by lateral hypothalamic electrical stimulation. Life sciences, 1983, Volume: 33 Suppl 1 Topics: Animals; Electric Stimulation; Feeding Behavior; Hypothalamus; Loperamide; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Reward	1983
Antidiarrhoeal activity of loperamide: studies of its influence on ion transport across rabbit ileal mucosa in vitro. Gut, 1982, Volume: 23, Issue:11 Topics: Animals; Bacterial Toxins; Biological Transport; Chlorides; Dinoprostone; Escherichia coli; Ileum; In Vitro Techniques; Intestinal Mucosa; Loperamide; Male; Membrane Potentials; Naloxone; Piperidines; Prostaglandins E; Rabbits; Sodium	1982
Effect of loperamide and naloxone on gastric acid secretion in healthy man. Gut, 1981, Volume: 22, Issue:9 Topics: Adult; Female; Gastric Acid; Gastric Mucosa; Humans; Loperamide; Male; Middle Aged; Naloxone; Pentagastrin; Piperidines	1981
Dependence liability of two antidiarrheals, nufenoxole and loperamide. Clinical pharmacology and therapeutics, 1980, Volume: 27, Issue:5 Topics: Adult; Antidiarrheals; Body Temperature; Electromyography; Humans; Loperamide; Male; Naloxone; Oxadiazoles; Piperidines; Pupil; Substance Withdrawal Syndrome; Substance-Related Disorders	1980
Unexpected prosecretory action component of loperamide at mu-opioid receptors in the guinea-pig colonic mucosa in vitro. British journal of pharmacology, 1995, Volume: 114, Issue:4 Topics: Alprostadil; Amino Acid Sequence; Animals; Chlorides; Colon; Dose-Response Relationship, Drug; Ethylketocyclazocine; Guinea Pigs; Intestinal Mucosa; Loperamide; Male; Molecular Sequence Data; Naloxone; Naltrexone; Patch-Clamp Techniques; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Theophylline	1995
Opioids and sexual behavior in the male rabbit: the role of central and peripheral opioid receptors. Journal of neural transmission. General section, 1994, Volume: 97, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Central Nervous System; Dose-Response Relationship, Drug; Ejaculation; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Loperamide; Male; Morphine; Naloxone; Narcotics; Oxymorphone; Peripheral Nervous System; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Sexual Behavior, Animal	1994
Absence of emetic effects of morphine and loperamide in Suncus murinus. European journal of pharmacology, 1994, May-02, Volume: 256, Issue:3 Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Loperamide; Male; Morphine; Naloxone; Nicotine; Serotonin; Serotonin Antagonists; Shrews; Vomiting	1994
In man the mu-opiate agonist loperamide specifically inhibits ACTH secretion induced by the cholecystokinin-like peptide ceruletide. Neuroendocrinology, 1994, Volume: 60, Issue:1 Topics: Adrenocorticotropic Hormone; Adult; Ceruletide; Drug Interactions; Humans; Hydrocortisone; Loperamide; Male; Naloxone; Placebos; Receptors, Opioid, mu	1994
Loperamide inhibits corticotrophic cell function by a naloxone-insensitive mechanism in the rat in vitro. Neuroendocrinology, 1993, Volume: 57, Issue:6 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Adrenocorticotropic Hormone; Animals; Calcium; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Loperamide; Male; Morphine; Naloxone; Phosphatidylinositols; Pituitary Gland, Anterior; Pro-Opiomelanocortin; Radioimmunoassay; Rats; Rats, Sprague-Dawley; RNA, Messenger; Second Messenger Systems	1993
Comparison of the effects of T-1815, yohimbine and naloxone on mouse colonic propulsion. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 1993, Volume: 29, Issue:2 Topics: Administration, Oral; Animals; Clonidine; Colon; Dose-Response Relationship, Drug; Gastrointestinal Motility; Loperamide; Male; Mice; Naloxone; Propylamines; Thiophenes; Yohimbine	1993
Smoked heroin self-administration in rhesus monkeys. Psychopharmacology, 1996, Volume: 125, Issue:3 Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Heroin; Loperamide; Macaca mulatta; Male; Naloxone; Narcotic Antagonists; Narcotics; Self Administration; Time Factors	1996
Loperamide poisoning in the dog. Veterinary and human toxicology, 1996, Volume: 38, Issue:1 Topics: Animals; Antidiarrheals; Digestive System Diseases; Dog Diseases; Dogs; Female; Follow-Up Studies; Loperamide; Male; Naloxone; Narcotic Antagonists; Poisoning; Retrospective Studies	1996
Antidiarrhoeal activity of new thiazolidinones related to loperamide. The Journal of pharmacy and pharmacology, 1996, Volume: 48, Issue:7 Topics: Animals; Antidiarrheals; Castor Oil; Diarrhea; Lethal Dose 50; Loperamide; Male; Mice; Naloxone; Narcotic Antagonists	1996
Role of tachykinins in castor oil diarrhoea in rats. British journal of pharmacology, 1997, Volume: 121, Issue:3 Topics: Animals; Benzamides; Castor Oil; Colon; Diarrhea; Gastrointestinal Motility; Loperamide; Male; Naloxone; Piperidines; Quinuclidines; Rats; Tachykinins	1997
Subcutaneous loperamide prevents gastric lesions induced by necrotizing agents in rats. Digestive diseases and sciences, 1997, Volume: 42, Issue:12 Topics: Animals; Ethanol; Gastric Mucosa; Hydrochloric Acid; Injections, Subcutaneous; Irritants; Loperamide; Male; Naloxone; Necrosis; Omeprazole; Rats; Rats, Sprague-Dawley	1997
Effects of N-methyl-D-aspartate receptor antagonists on discriminative stimulus effects of naloxone in morphine-dependent rats using the Y-maze drug discrimination paradigm. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:3 Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Loperamide; Male; Maze Learning; Morphine Dependence; Motor Activity; Naloxone; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate	1998
Characterization of the antihyperalgesic action of a novel peripheral mu-opioid receptor agonist--loperamide. Anesthesiology, 1999, Volume: 90, Issue:1 Topics: Analgesics; Analgesics, Opioid; Animals; Burns; Drug Tolerance; Hindlimb; Hyperalgesia; Loperamide; Male; Morphine; Naloxone; Narcotic Antagonists; Nociceptors; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu	1999
Activation of opioid mu-receptor by loperamide to lower plasma glucose in streptozotocin-induced diabetic rats. Neuroscience letters, 1999, Apr-23, Volume: 265, Issue:3 Topics: Animals; Antidiarrheals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucose; Hyperglycemia; Injections, Intravenous; Loperamide; Male; Muscle, Skeletal; Naloxone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, mu	1999
Inhibition of thromboxane A(2)-induced Cl(-) secretion by antidiarrhea drug loperamide in isolated rat colon. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:1 Topics: Animals; Antidiarrheals; Calcium; Camptothecin; Chlorides; Colon; Dinoprostone; Female; In Vitro Techniques; Irinotecan; Loperamide; Naloxone; Rats; Rats, Wistar; Thromboxane A2	2000
Antisecretory effect of loperamide in colon epithelial cells by inhibition of basolateral K+ conductance. Scandinavian journal of gastroenterology, 2001, Volume: 36, Issue:7 Topics: Antidiarrheals; Calcium Channel Blockers; Calmodulin; Carbachol; Chlorides; Cholinergic Agonists; Colforsin; Colon; Drug Evaluation, Preclinical; Enterocytes; HT29 Cells; Humans; Intestinal Mucosa; Loperamide; Naloxone; Narcotic Antagonists; Potassium Channels; Signal Transduction; Time Factors; Trifluoperazine; Verapamil	2001
Effects of loperamide and other opioid-related substances on the transcriptional regulation of the rat pro-opiomelanocortin gene in AtT20 cells. Neuroendocrinology, 2001, Volume: 74, Issue:2 Topics: Animals; Cells, Cultured; Colforsin; Dose-Response Relationship, Drug; Gene Expression; Loperamide; Mice; Naloxone; Nifedipine; Nociceptin; Oligopeptides; Opioid Peptides; Pro-Opiomelanocortin; Receptors, Opioid, mu; Sulfonamides; Time Factors	2001
Comparison of the peripheral and central effects of the opioid agonists loperamide and morphine in the formalin test in rats. Neuropharmacology, 2002, Volume: 42, Issue:2 Topics: Analgesics, Opioid; Animals; Antidiarrheals; Cisterna Magna; Dose-Response Relationship, Drug; Formaldehyde; Injections; Injections, Subcutaneous; Loperamide; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2002
Spinal and peripheral mu opioids and the development of secondary tactile allodynia after thermal injury. Anesthesia and analgesia, 2002, Volume: 94, Issue:4 Topics: Administration, Topical; Analgesics, Opioid; Animals; Burns; Hindlimb; Hyperalgesia; Injections, Spinal; Loperamide; Male; Morphine; Naloxone; Narcotic Antagonists; Neural Pathways; Neurons, Afferent; Pain Threshold; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Remifentanil; Spinal Cord; Touch	2002
Antidiarrhoeal activity of seed extract of Albizzia lebbeck Benth. Phytotherapy research : PTR, 2002, Volume: 16, Issue:6 Topics: Animals; Antidiarrheals; Castor Oil; Diarrhea; Fabaceae; Gastrointestinal Transit; Lethal Dose 50; Loperamide; Mice; Naloxone; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Seeds; Toxicity Tests, Acute	2002
Antidiarrhoeal activity of hot water extract of black tea (Camellia sinensis). Phytotherapy research : PTR, 2003, Volume: 17, Issue:4 Topics: Animals; Antidiarrheals; Castor Oil; Diarrhea; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gastrointestinal Motility; Loperamide; Male; Mice; Mice, Inbred BALB C; Naloxone; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Tea	2003
Dose-response relationship and mechanism of action of Saccharomyces boulardii in castor oil-induced diarrhea in rats. Digestive diseases and sciences, 2003, Volume: 48, Issue:4 Topics: Animals; Antidiarrheals; Arginine; Castor Oil; Diarrhea; Dose-Response Relationship, Drug; Fungal Vaccines; Indomethacin; Loperamide; Male; Naloxone; Probiotics; Rats; Rats, Wistar; Saccharomyces; Water-Electrolyte Balance	2003
Peripheral opioids act as analgesics in bone cancer pain in mice. Neuroreport, 2003, May-06, Volume: 14, Issue:6 Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Cell Culture Techniques; Hyperalgesia; Loperamide; Mice; Mice, Inbred C3H; Morphine; Naloxone; Narcotic Antagonists; Osteosarcoma; Pain; Quaternary Ammonium Compounds	2003
Analgesic action of loperamide, an opioid agonist, and its blocking action on voltage-dependent Ca2+ channels. Neuroscience research, 2003, Volume: 46, Issue:4 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Analgesia; Analgesics; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Space; Fluorescent Dyes; Fura-2; Loperamide; Mice; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Posterior Horn Cells; Potassium Chloride	2003
Signals in the activation of opioid mu-receptors by loperamide to enhance glucose uptake into cultured C2C12 cells. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2004, Volume: 36, Issue:4 Topics: Animals; Antidiarrheals; Cell Line; Deoxyglucose; Glucose; Loperamide; Mice; Muscle Fibers, Skeletal; Naloxone; Narcotic Antagonists; Protein Kinase C; Receptors, Opioid, mu; Signal Transduction; Type C Phospholipases	2004
[Loss of consciousness in a child due to loperamide]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2004, Volume: 11, Issue:7 Topics: Antidiarrheals; Child, Preschool; Female; Humans; Loperamide; Naloxone; Narcotic Antagonists; Unconsciousness	2004
Nociceptive sensitivity and opioid antinociception and antihyperalgesia in Freund's adjuvant-induced arthritic male and female rats. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:1 Topics: Analgesics, Opioid; Animals; Arthritis, Experimental; Body Weight; Butorphanol; Dose-Response Relationship, Drug; Estrous Cycle; Female; Foot; Freund's Adjuvant; Hyperalgesia; Loperamide; Male; Morphine; Naloxone; Narcotic Antagonists; Nociceptors; Oxycodone; Pain Measurement; Pressure; Rats; Rats, Inbred Lew; Sex Characteristics	2005
Activation of opioid mu-receptors by loperamide to improve interleukin-6-induced inhibition of insulin signals in myoblast C2C12 cells. Diabetologia, 2005, Volume: 48, Issue:7 Topics: Animals; Biological Transport; Cell Line; Deoxyglucose; Insulin; Interleukin-6; Loperamide; Mice; Naloxone; Phosphoproteins; Phosphorylation; Receptors, Opioid, mu; Signal Transduction	2005
Synthesis and pharmacological activity of 2-(substituted)-3-{2-[(4-phenyl-4-cyano)piperidino]ethyl}-1,3-thiazolidin-4-ones. Chemical biology & drug design, 2006, Volume: 67, Issue:6 Topics: Animals; Antidiarrheals; Castor Oil; Diarrhea; Loperamide; Mice; Models, Molecular; Naloxone; Structure-Activity Relationship; Thiazolidinediones	2006
Activation of mu-opioid receptors improves insulin sensitivity in obese Zucker rats. Life sciences, 2007, Mar-27, Volume: 80, Issue:16 Topics: Analysis of Variance; Animals; Blood Glucose; Immunoblotting; Immunoprecipitation; Insulin Resistance; Loperamide; Mice; Mice, Knockout; Naloxone; Rats; Rats, Zucker; Receptors, Opioid, mu	2007
Direct inhibition of Ih by analgesic loperamide in rat DRG neurons. Journal of neurophysiology, 2007, Volume: 97, Issue:5 Topics: Analgesics; Animals; Cells, Cultured; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Ganglia, Spinal; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Loperamide; Membrane Potentials; Naloxone; Narcotic Antagonists; Neural Inhibition; Neurons; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Wistar	2007
Involvement of nitric oxide in the inhibition of bone cancer-induced hyperalgesia through the activation of peripheral opioid receptors in mice. Neuropharmacology, 2007, Volume: 53, Issue:1 Topics: Analysis of Variance; Animals; Bone Neoplasms; Carbazoles; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Glyburide; Hyperalgesia; Indoles; Loperamide; Mice; Mice, Inbred C3H; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Pain Measurement; Receptors, Opioid	2007
Effects of loperamide on mechanical allodynia induced by herpes simplex virus type-1 in mice. Journal of pharmacological sciences, 2007, Volume: 104, Issue:3 Topics: Analgesics, Opioid; Animals; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Tolerance; Female; Foot; Herpes Simplex; Herpesvirus 1, Human; Injections; Injections, Subcutaneous; Loperamide; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Physical Stimulation	2007
Validation of 13C-acetic acid breath test by measuring effects of loperamide, morphine, mosapride, and itopride on gastric emptying in mice. Biological & pharmaceutical bulletin, 2008, Volume: 31, Issue:10 Topics: Acetic Acid; Analgesics, Opioid; Animals; Anti-Ulcer Agents; Antidiarrheals; Antiemetics; Benzamides; Benzyl Compounds; Breath Tests; Coloring Agents; Gastric Emptying; Loperamide; Male; Mice; Morphine; Morpholines; Naloxone; Narcotic Antagonists; Phenolsulfonphthalein; Reproducibility of Results	2008
Spinal antinociceptive action of loperamide is mediated by opioid receptors in the formalin test in rats. Neuroscience letters, 2008, Dec-31, Volume: 448, Issue:3 Topics: Analgesics; Animals; Behavior, Animal; Formaldehyde; Injections, Spinal; Loperamide; Male; Naloxone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord	2008
Competitive substrates for P-glycoprotein and organic anion protein transporters differentially reduce blood organ transport of fentanyl and loperamide: pharmacokinetics and pharmacodynamics in Sprague-Dawley rats. Anesthesia and analgesia, 2009, Volume: 108, Issue:1 Topics: Analgesics, Opioid; Animals; ATP Binding Cassette Transporter, Subfamily B; Binding, Competitive; Brain; Electroencephalography; Fentanyl; Infusions, Intravenous; Loperamide; Lung; Male; Models, Biological; Naloxone; Organic Anion Transporters; Pravastatin; Rats; Rats, Sprague-Dawley; Tissue Distribution; Verapamil	2009
Mediation of protein kinase C zeta in mu-opioid receptor activation for increase of glucose uptake into cultured myoblast C2C12 cells. Neuroscience letters, 2009, Nov-13, Volume: 465, Issue:2 Topics: Animals; Blotting, Western; Carbon Radioisotopes; Cell Line; Deoxyglucose; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Indoles; Loperamide; Maleimides; Mice; Myoblasts, Skeletal; Naloxone; Narcotic Antagonists; Phosphorylation; Protein Kinase C; Receptors, Opioid, mu	2009
Characterization of two models of drug-induced constipation in mice and evaluation of mustard oil in these models. Pharmacology, 2009, Volume: 84, Issue:4 Topics: Animals; Atropine; Clonidine; Constipation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Gastrointestinal Transit; Indoles; Loperamide; Male; Mice; Mice, Inbred Strains; Mustard Plant; Naloxone; Plant Oils; Transient Receptor Potential Channels; TRPA1 Cation Channel; Yohimbine	2009
Modulation of peripheral opioid receptors affects the concentration of mu-opioid receptors in rat brain. Bulletin of experimental biology and medicine, 2009, Volume: 148, Issue:3 Topics: Animals; Blood-Brain Barrier; Brain; Hypothalamus; Loperamide; Male; Mesencephalon; Naloxone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, mu	2009
Involvement of peripheral mu opioid receptors in scratching behavior in mice. European journal of pharmacology, 2010, Dec-15, Volume: 649, Issue:1-3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Antipruritics; Behavior, Animal; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Injections, Intradermal; Loperamide; Male; Mice; Mice, Inbred ICR; Naloxone; Opioid-Related Disorders; Pruritus; Quaternary Ammonium Compounds; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Skin	2010
Changes in β-endorphin level in the cingulate cortex in rats after peripheral loperamide and methylnaloxone administration at rest and during emotional stress. Bulletin of experimental biology and medicine, 2010, Volume: 149, Issue:2 Topics: Animals; beta-Endorphin; Blood-Brain Barrier; Enzyme-Linked Immunosorbent Assay; Extracellular Space; Gyrus Cinguli; Loperamide; Microdialysis; Naloxone; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Opioid, mu; Stress, Psychological	2010
Peripheral administration of loperamide and methylnaloxone decreases the degree of anxiety in rats. Bulletin of experimental biology and medicine, 2010, Volume: 149, Issue:3 Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Loperamide; Male; Maze Learning; Naloxone; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Opioid, mu; Swimming; Time Factors	2010
Loperamide-induced rat prostate relaxation through activation of peripheral µ-opioid receptors. Neurourology and urodynamics, 2011, Volume: 30, Issue:3 Topics: Analysis of Variance; Animals; Blotting, Western; Dose-Response Relationship, Drug; Glyburide; In Vitro Techniques; Loperamide; Male; Muscle Relaxation; Naloxone; Narcotic Antagonists; Potassium; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Prostate; Rats; Rats, Wistar; Receptors, Opioid, mu	2011
Activation of peripheral opioid µ-receptors in blood vessel may lower blood pressure in spontaneously hypertensive rats. Pharmacology, 2011, Volume: 87, Issue:5-6 Topics: Animals; Arteries; Blood Pressure; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Endothelium; Glyburide; Hemodynamics; Intracellular Signaling Peptides and Proteins; KATP Channels; Loperamide; Male; Morphinans; Naloxone; Phenylephrine; Phosphodiesterase Inhibitors; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Opioid, mu; Vasodilation	2011
Urinary bladder relaxation through activation of opioid μ-receptors induced by loperamide is increased in diabetic rats. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2012, Volume: 120, Issue:6 Topics: Animals; Antidiarrheals; Cells, Cultured; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; Loperamide; Male; Muscle Relaxation; Muscle, Smooth; Naloxone; Narcotic Antagonists; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, Opioid, mu; Streptozocin; Urinary Bladder	2012
Opiate-induced constipation related to activation of small intestine opioid μ2-receptors. World journal of gastroenterology, 2012, Mar-28, Volume: 18, Issue:12 Topics: Acetylcholine; Analgesics, Opioid; Animals; Antidiarrheals; Constipation; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gastrointestinal Transit; Glyburide; Humans; Intestine, Small; Loperamide; Male; Mice; Mice, Inbred BALB C; Morphinans; Muscle Relaxation; Naloxone; Receptors, Opioid, mu	2012
Analgesic properties of loperamide differ following systemic and local administration to rats after spinal nerve injury. European journal of pain (London, England), 2012, Volume: 16, Issue:7 Topics: Analgesia; Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Loperamide; Male; Naloxone; Pain Measurement; Pain Threshold; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Spinal Nerves	2012
Prosecretory effect of loperamide in ileal and colonic mucosae of mice displaying high or low swim stress-induced analgesia associated with high and low endogenous opioid system activity. Neurogastroenterology and motility, 2018, Volume: 30, Issue:2 Topics: Analgesics, Opioid; Animals; Castor Oil; Colon; Diarrhea; Ileum; Intestinal Mucosa; Loperamide; Male; Mice; Naloxone; Narcotic Antagonists; Stress, Psychological	2018
Suppression of Human Natural Killer Cells by Different Classes of Opioids. Anesthesia and analgesia, 2019, Volume: 128, Issue:5 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Anesthesia; Buprenorphine; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Fluoresceins; Humans; Immunosuppression Therapy; K562 Cells; Killer Cells, Natural; Loperamide; Methadone; Morphinans; Morphine; Naloxone; Naltrexone; Succinimides; Toll-Like Receptor 4; Tramadol	2019
Loperamide Addiction: Atypical Opioid Use Disorder Treated With Buprenorphine/Naloxone. The primary care companion for CNS disorders, 2019, Jul-03, Volume: 21, Issue:4 Topics: Abuse-Deterrent Formulations; Adult; Analgesics, Opioid; Buprenorphine; Drug Therapy, Combination; Female; Humans; Loperamide; Naloxone; Narcotic Antagonists; Opioid-Related Disorders	2019
Loperamide Abuse and Its Sequelae. The American journal of forensic medicine and pathology, 2020, Volume: 41, Issue:3 Topics: Adult; Antidiarrheals; Crohn Disease; Fatal Outcome; Humans; Hypoxia, Brain; Loperamide; Male; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Pancreatitis	2020
Divergent Electrophysiological Effects of Loperamide and Naloxone in a Sensitive Whole-Heart Model. Cardiovascular toxicology, 2021, Volume: 21, Issue:3 Topics: Action Potentials; Analgesics, Opioid; Animals; Antidiarrheals; Cardiac Pacing, Artificial; Cardiotoxicity; Female; Heart; Heart Rate; Isolated Heart Preparation; Loperamide; Naloxone; Narcotic Antagonists; Rabbits; Tachycardia, Ventricular; Time Factors	2021
Cardiac Electropharmacological Effects of Antidiarrheal Drug Loperamide and Its Antidote Naloxone in Anesthetized Guinea Pigs. Biological & pharmaceutical bulletin, 2022, Volume: 45, Issue:4 Topics: Animals; Antidiarrheals; Antidotes; Guinea Pigs; Heart; Loperamide; Naloxone	2022
The effects of loperamide on excitatory and inhibitory neuromuscular function in the human colon. Neurogastroenterology and motility, 2022, Volume: 34, Issue:11 Topics: Animals; Colon; Electric Stimulation; Gastrointestinal Motility; Humans; Loperamide; Muscle Contraction; Naloxone; Nitroarginine; Scopolamine	2022
Use of tracking drugs for the search of intra-hospital adverse reactions: a pharmacovigilance study. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria, 2022, 04-26, Volume: 46, Issue:3 Topics: Adverse Drug Reaction Reporting Systems; Cross-Sectional Studies; Diphenhydramine; Drug-Related Side Effects and Adverse Reactions; Flumazenil; Hospitals; Humans; Loperamide; Naloxone; Pharmacovigilance; Promethazine	2022