loperamide has been researched along with n-demethylloperamide in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (31.82) | 29.6817 |
| 2010's | 14 (63.64) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Bao, JQ; Bedwell, DW; Higgins, JW; Zamek-Gliszczynski, MJ | 1 |
| Kang, J; Luo, Y; Rampe, D; Vaz, RJ | 1 |
| Erve, JC; Hachey, DL; He, H; Sadeque, A; Wood, AJ | 1 |
| Kalgutkar, AS; Nguyen, HT | 1 |
| Allan, C; Fowler, D; Levine, B; Moore, KA; Sklerov, J | 1 |
| Backman, JT; Fredrikson, H; Neuvonen, PJ; Niemi, M; Pasanen, MK; Tornio, A | 1 |
| Gladding, RL; Hong, J; Innis, RB; Lazarova, N; Liow, JS; Pike, VW; Seneca, N; Taku, A; Tuan, E; Zoghbi, SS | 1 |
| Gladding, RL; Herscovitch, P; Innis, RB; Kreisl, W; Lazarova, N; Liow, JS; Pike, VW; Seneca, N; Taku, A; Zoghbi, SS | 1 |
| Gladding, RL; Herscovitch, P; Innis, RB; Jenko, K; Kreisl, W; Liow, JS; Pike, VW; Seneca, N; Taku, A; Zoghbi, SS | 1 |
| Brimacombe, KR; Gottesman, MM; Hall, MD; Halldin, C; Innis, RB; Kannan, P; Liow, JS; Morse, C; Pike, VW; Taku, AK; Zoghbi, SS | 1 |
| Herscovitch, P; Innis, RB; Kimura, N; Kreisl, WC; Liow, JS; Morse, CL; Pike, VW; Seneca, N; Zoghbi, SS | 1 |
| Brimacombe, KR; Gottesman, MM; Hall, MD; Halldin, C; Innis, RB; Kannan, P; Kreisl, WC; Liow, JS; Pike, VW; Telu, S; Zhang, Y; Zoghbi, SS | 1 |
| Boon, P; De Vos, F; Moerman, L; Raedt, R; Slaets, D; Wyffels, L | 1 |
| Boon, P; De Vos, F; Dumolyn, C; Moerman, L | 1 |
| Amano, N; Hirabayashi, H; Moriwaki, T; Sugimoto, H | 1 |
| Bae, SA; Chong, DJ; Easwaramoorthy, B; Farwell, MD; Ichise, M; Iida, Y | 1 |
| Gao, M; Wang, M; Zheng, QH | 1 |
| Bhatia, R; Innis, RB; Kreisl, WC; Morse, CL; Pike, VW; Shetty, HU; Woock, AE; Zoghbi, SS | 1 |
| Bauer, F; Erker, T; Filip, T; Kuntner, C; Langer, O; Löscher, W; Mairinger, S; Müller, M; Pahnke, J; Römermann, K; Sauberer, M; Stanek, J; Traxl, A; Wanek, T | 1 |
| Auvity, S; Damont, A; Goutal, S; Kuhnast, B; Saba, W; Tournier, N; Valette, H | 1 |
| Bhatti, Z; Norsworthy, J; Szombathy, T | 1 |
| Anoshchenko, O; Storelli, F; Unadkat, JD | 1 |
3 trial(s) available for loperamide and n-demethylloperamide
| Article | Year |
|---|---|
Itraconazole, gemfibrozil and their combination markedly raise the plasma concentrations of loperamide.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Central Nervous System; Cross-Over Studies; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Enzyme Inhibitors; Female; Gemfibrozil; Humans; Itraconazole; Loperamide; Male | 2006 |
P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Blood-Brain Barrier; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Kinetics; Loperamide; Magnetic Resonance Imaging; Male; Positron-Emission Tomography; Quinolines; Radioactive Tracers | 2010 |
Increased permeability-glycoprotein inhibition at the human blood-brain barrier can be safely achieved by performing PET during peak plasma concentrations of tariquidar.
Topics: Administration, Intravenous; Administration, Oral; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Dose-Response Relationship, Drug; Female; Humans; Loperamide; Male; Permeability; Positron-Emission Tomography; Quinolines; Safety | 2015 |
19 other study(ies) available for loperamide and n-demethylloperamide
| Article | Year |
|---|---|
Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics.
Topics: Administration, Oral; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Availability; Biotransformation; Brain; Fluoresceins; Gene Knockout Techniques; Genotype; Half-Life; Loperamide; Male; Metabolic Clearance Rate; Paclitaxel; Phenotype; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Rats, Wistar; Sulfasalazine; Tissue Distribution | 2012 |
Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K
Topics: Dose-Response Relationship, Drug; ERG1 Potassium Channel; Humans; Loperamide; Models, Molecular; Molecular Structure; Potassium Channel Blockers; Structure-Activity Relationship | 2018 |
Quantitation of loperamide and N-demethyl-loperamide in human plasma using electrospray ionization with selected reaction ion monitoring liquid chromatography-mass spectrometry.
Topics: Adult; Calibration; Chromatography, High Pressure Liquid; Humans; Loperamide; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2000 |
Identification of an N-methyl-4-phenylpyridinium-like metabolite of the antidiarrheal agent loperamide in human liver microsomes: underlying reason(s) for the lack of neurotoxicity despite the bioactivation event.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Antidiarrheals; Bupropion; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dealkylation; Haloperidol; Humans; Hydroxylation; Ketoconazole; Loperamide; Male; Microsomes, Liver; NADP; Neurons; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Time Factors | 2004 |
Tissue distribution of loperamide and N-desmethylloperamide following a fatal overdose.
Topics: Adult; Antidiarrheals; Chromatography, High Pressure Liquid; Drug Overdose; Fatal Outcome; Forensic Pathology; Humans; Loperamide; Male; Tissue Distribution | 2005 |
Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Brain; Carbon Radioisotopes; Injections, Intravenous; Loperamide; Macaca mulatta; Male; Mice; Mice, Knockout; Molecular Structure; Positron-Emission Tomography; Radiopharmaceuticals; Stereoisomerism; Time Factors | 2008 |
P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Humans; Loperamide; Macaca mulatta; Male; Positron-Emission Tomography; Radioactivity; Regional Blood Flow; Tissue Distribution | 2009 |
Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Body Burden; Brain; Female; Humans; Loperamide; Male; Metabolic Clearance Rate; Organ Specificity; Positron-Emission Tomography; Radiation Dosage; Radiometry; Radiopharmaceuticals; Tissue Distribution | 2009 |
N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier.
Topics: Animals; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Blood-Brain Barrier; Brain; Cerebrovascular Circulation; Glycoproteins; Humans; Loperamide; Mice; Multidrug Resistance-Associated Proteins; Radiopharmaceuticals; Tissue Distribution; Tumor Cells, Cultured | 2010 |
Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line, Tumor; Humans; Isotope Labeling; Loperamide; Lysosomes; Mice; Positron-Emission Tomography; Quinolines; Radiography; Tritium | 2011 |
Antiepileptic drugs modulate P-glycoproteins in the brain: a mice study with (11)C-desmethylloperamide.
Topics: Analysis of Variance; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Blood-Brain Barrier; Brain; Carbon Isotopes; Dose-Response Relationship, Drug; Drug Interactions; Loperamide; Male; Mice; Mice, Knockout; Radioligand Assay; Radionuclide Imaging; Time Factors | 2011 |
The influence of mass of [11C]-laniquidar and [11C]-N-desmethyl-loperamide on P-glycoprotein blockage at the blood-brain barrier.
Topics: Animals; Antidiarrheals; ATP Binding Cassette Transporter, Subfamily B; Benzazepines; Biological Transport; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Case-Control Studies; Drug Carriers; Loperamide; Male; Mice; Mice, Knockout; Quinolines; Tissue Distribution | 2012 |
Retrospective analysis of P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Drug Interactions; Humans; LLC-PK1 Cells; Loperamide; Quinolines; Swine; Verapamil | 2013 |
Imaging P-glycoprotein function in rats using [(11)C]-N-desmethyl-loperamide.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Brain; Cyclosporine; Kinetics; Loperamide; Male; Positron-Emission Tomography; Quinolines; Rats; Rats, Sprague-Dawley | 2013 |
A high-yield route to synthesize the P-glycoprotein radioligand [11C]N-desmethyl-loperamide and its parent radioligand [11C]loperamide.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Ligands; Loperamide; Molecular Structure; Radiopharmaceuticals; Solid Phase Extraction | 2013 |
Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Biological Transport; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Carbon Radioisotopes; Drug Interactions; Female; Humans; Loperamide; Mice; Mice, Inbred C57BL; Mice, Knockout; Positron-Emission Tomography; Radiopharmaceuticals; Verapamil | 2015 |
Imaging the impact of cyclosporin A and dipyridamole on P-glycoprotein (ABCB1) function at the blood-brain barrier: A [(11)C]-N-desmethyl-loperamide PET study in nonhuman primates.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Carbon Radioisotopes; Cyclosporine; Dipyridamole; Loperamide; Male; Papio; Positron-Emission Tomography | 2016 |
Loperamide metabolite-induced cardiomyopathy and QTc prolongation.
Topics: Adult; Antidiarrheals; Biotransformation; Cardiomyopathies; Drug Overdose; Electrocardiography; Female; Humans; Long QT Syndrome; Loperamide; Predictive Value of Tests; Suicide, Attempted | 2017 |
Successful Prediction of Human Steady-State Unbound Brain-to-Plasma Concentration Ratio of P-gp Substrates Using the Proteomics-Informed Relative Expression Factor Approach.
Topics: Algorithms; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Brain Chemistry; Dogs; Endothelial Cells; Extracellular Fluid; Forecasting; Gene Expression Regulation; Humans; Loperamide; Madin Darby Canine Kidney Cells; Metoclopramide; Positron-Emission Tomography; Proteomics; Verapamil | 2021 |