loperamide and morphine

loperamide has been researched along with morphine in 71 studies

Research

Studies (71)

Timeframe	Studies, this research(%)	All Research%
pre-1990	30 (42.25)	18.7374
1990's	14 (19.72)	18.2507
2000's	16 (22.54)	29.6817
2010's	10 (14.08)	24.3611
2020's	1 (1.41)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B	1
Calderone, V; Campiglia, P; Carotenuto, A; Giusti, L; Gomez-Monterrey, I; Grieco, P; Lama, T; Mazzoni, MR; Novellino, E; Tartaro, G	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Antonsson, M; Bengtsson, O; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Jerndal, G; Wan, H; Winiwarter, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Clay, GA; Dajani, EZ; Mackerer, CR	1
Clay, GA; Lin, TK; Mackerer, CR	1
Bloss, JL; Brougham, LR; Clay, GA; Dajani, EZ; East, PF; Mackerer, CR	1
John, GI	1
Beubler, E; Lembeck, F	1
Fujiwara, M; Muramatsu, I; Nakashima, M; Shikimi, T	1
Heykants, JJ; Janssen, PA; McGuire, JL; Niemegeers, CJ	1
Herz, A; Schulz, R; Wüster, M	1
Mizutani, M; Nakayama, S; Yamasato, T	1
Kawashima, K; Shimizu, M; Sohji, Y	1
Alexander, F	1
Grouhel, A; Junien, JL; Pascaud, X; Roman, FJ; Soulard, C	1
Agmo, A; Rojas, J; Vázquez, P	1
Burleigh, DE	2
Butt, W; Cowan, A; Fisher, RS; Krevsky, B; Maurer, AH	1
Otterson, MF; Sarna, SK	1
Burks, TF; Norman, JA; Shook, JE; Wasley, JW	1
Linseman, MA	1
Diener, M; Knobloch, SF; Rummel, W	1
Bansinath, M; Bhargava, HN	1
Bhargava, KP; Gupta, GP; Gupta, MB	1
Bryant, HU; Kuta, CC; Story, JA; Yim, GK	1
Jivegård, L; Svanvik, J	1
Cookson, J; Hardcastle, J; Hardcastle, PT	1
Buchwald, WF; Cone, EJ; Darwin, WD; Gorodetzky, CW; Pickworth, WB; Risner, ME; Sharpe, LG	1
Bueno, L; Latour, A	1
Awouters, F; Janssen, PA; Niemegeers, CJ	1
Casiraghi, L; Giagnoni, G; Gori, E; Parolaro, D; Revel, L; Sala, M; Senini, R	1
Burleigh, DE; D'Mello, A	1
Turnberg, LA	1
Carr, KD; Simon, EJ	1
Alioto, RL; Mir, GN	1
Burks, TF; Burleigh, DE; Galligan, JJ	1
Agmo, A; Contreras, JL; Paredes, RG	1
Friderichs, E; Reimann, W; Reinartz, S; Selve, N	1
Auernhammer, CJ; Müller, OA; Renner, U; Stalla, GK; Stalla, J	1
Coupar, IM; De Luca, A	2
Coupar, IM	1
Lê, AD; Linseman, MA	1
Pol, O; Puig, MM	1
Nozaki-Taguchi, N; Yaksh, TL	2
Lutz, EA; Shannon, HE	1
Kim, R; Wandel, C; Wood, A; Wood, M	1
Baker, A; Meert, T	1
Baamonde, A; García, E; Hidalgo, A; Lastra, A; Meana, A; Menéndez, L	1
Cook, CD; Nickerson, MD	1
Ray, SB; Verma, D; Wadhwa, S	1
Bespalov, AY; Danysz, W; Sevostianova, N	1
Basavarajappa, BS; Basavarajppa, BS; Carai, MA; Colombo, G; Gessa, GL; Hungund, BL; Yalamanchili, R	1
Andoh, T; Kuraishi, Y; Nakashima, Y; Sasaki, A; Shiraki, K; Takasaki, I	1
Horie, S; Kimura, H; Matsumoto, K; Tashima, K; Uchida, M	1
Sudakov, SK; Trigub, MM	1
Cobuzzi, JL; Davis, CM; Riley, AL	1
Raja, SN; Ringkamp, M	1
Al-Khrasani, M; Fürst, S; Khalefa, BI; Mousa, SA; Schäfer, M; Shaqura, M	1
Kumar, R; Ray, SB; Reeta, KH	1
Bao, X; Jin, Y; Liu, D; Yang, Y	1
Ambrosio, E; Bagues, A; Esteban-Hernández, J; Higuera-Matas, A; Martín, MI; Sánchez-Robles, EM	1
Heller, NM; Maher, DP; Walia, D	1
Jyothi, B; Korikanthimath, VV; Kurugodiyavar, MD; Mitragotri, MV; Shaikh, SI	1

Reviews

4 review(s) available for loperamide and morphine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Pharmacology of antidiarrheal drugs. Annual review of pharmacology and toxicology, 1983, Volume: 23 Topics: Animals; Antidiarrheals; Biological Transport; Body Fluids; Castor Oil; Diarrhea; Diphenoxylate; Electrolytes; Gastrointestinal Motility; Humans; Ileum; Intestinal Mucosa; Kinetics; Loperamide; Morphine; Narcotics; Peristalsis; Receptors, Opioid	1983
Neural and pharmacologic factors affecting motility of the internal anal sphincter. Gastroenterology, 1983, Volume: 84, Issue:2 Topics: Acetylcholine; Adenosine Triphosphate; Anal Canal; Animals; Autonomic Nervous System; Bethanechol Compounds; Catecholamines; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Gastrointestinal Motility; Histamine; Humans; Loperamide; Morphine; Muscle Contraction; Muscle, Smooth; Nicotine; Prostaglandins; Serotonin; Vasoactive Intestinal Peptide	1983
Insights into opioid action in the intestinal tract. Pharmacology & therapeutics, 1996, Volume: 69, Issue:2 Topics: Analgesics, Opioid; Animals; Antidiarrheals; Constipation; Diarrhea; Gastrointestinal Motility; Guinea Pigs; Intestinal Mucosa; Loperamide; Morphine; Receptors, Opioid; Substance Withdrawal Syndrome	1996

Trials

2 trial(s) available for loperamide and morphine

Article	Year
Symptomatic treatment of acute self-limiting diarrhoea in adults. The Practitioner, 1977, Volume: 219, Issue:1311 Topics: Clinical Trials as Topic; Diarrhea; Drug Combinations; Humans; Kaolin; Loperamide; Morphine; Piperidines	1977
Morphine Versus Loperamide with Intrasite Gel in the Treatment of Painful Dermal Ulcers: A Randomized, Crossover Study. Pain physician, 2021, Volume: 24, Issue:1 Topics: Adult; Analgesics; Cross-Over Studies; Feasibility Studies; Humans; Hydrogels; Loperamide; Male; Middle Aged; Morphine; Pain; Pain Management; Pilot Projects; Skin Ulcer	2021

Other Studies

65 other study(ies) available for loperamide and morphine

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Predicting blood-brain barrier permeation from three-dimensional molecular structure. Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11 Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Morphiceptin analogues containing a dipeptide mimetic structure: an investigation on the bioactive topology at the mu-receptor. Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: Animals; Binding Sites; Brain; Computer Simulation; Dipeptides; Endorphins; Guinea Pigs; Ileum; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Micelles; Models, Molecular; Molecular Conformation; Molecular Mimicry; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Rats; Receptors, Opioid, mu; Sodium Dodecyl Sulfate; Structure-Activity Relationship	2005
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. Journal of medicinal chemistry, 2009, Oct-22, Volume: 52, Issue:20 Topics: Animals; Blood-Brain Barrier; Brain; Extracellular Fluid; Humans; Linear Models; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution	2011
Loperamide binding to opiate receptor sites of brain and myenteric plexus. The Journal of pharmacology and experimental therapeutics, 1976, Volume: 199, Issue:1 Topics: Analgesics, Opioid; Animals; Brain; Electric Stimulation; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Loperamide; Male; Morphine; Muscle Contraction; Myenteric Plexus; Naloxone; Piperidines; Reaction Time; Receptors, Opioid	1976
Interaction of loperamide with [3H]naloxone binding sites in guinea pig brain and myenteric plexus. Molecular pharmacology, 1977, Volume: 13, Issue:3 Topics: Animals; Binding Sites; Brain; Drug Interactions; Electric Stimulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; Loperamide; Male; Morphine; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Piperidines; Receptors, Opioid	1977
Antidiarrheal and central nervous system activities of SC-27166 (2-[3 - 5 - methyl - 1, 3, 4 - oxadiazol - 2 - yl) - 3, 3 - diphenylpropyl] - 2 - azabicyclo [2.2.2]octane), a new antidiarrheal agent, resulting from binding to opiate receptor sites of brai The Journal of pharmacology and experimental therapeutics, 1977, Volume: 203, Issue:3 Topics: Animals; Antidiarrheals; Brain; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Central Nervous System; Gastrointestinal Motility; Guinea Pigs; Humans; In Vitro Techniques; Loperamide; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Substance-Related Disorders	1977
Inhibition of stimulated fluid secretion in the rat small and large intestine by opiate agonists. Naunyn-Schmiedeberg's archives of pharmacology, 1979, Volume: 306, Issue:2 Topics: Animals; Bethanechol Compounds; Carbachol; Dextrorphan; Female; In Vitro Techniques; Intestinal Secretions; Intestine, Large; Intestine, Small; Levorphanol; Loperamide; Morphine; Naloxone; Narcotic Antagonists; Prostaglandins E; Rats; Vasoactive Intestinal Peptide	1979
Effects of loperamide on the guinea pig taenia coli. European journal of pharmacology, 1979, Apr-15, Volume: 55, Issue:2 Topics: Acetylcholine; Animals; Colon; Drug Interactions; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Loperamide; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Nicotine; Piperidines; Serotonin	1979
Dissociation between opiate-like and antidiarrheal activities of antidiarrheal drugs. The Journal of pharmacology and experimental therapeutics, 1979, Volume: 210, Issue:3 Topics: Administration, Oral; Animals; Antidiarrheals; Bridged Bicyclo Compounds; Castor Oil; Codeine; Diphenoxylate; Dose-Response Relationship, Drug; Injections, Intravenous; Lethal Dose 50; Loperamide; Male; Morphine; Narcotics; Oxadiazoles; Rats; Reaction Time	1979
Centrally and peripherally mediated inhibition of intestinal motility by opioids. Naunyn-Schmiedeberg's archives of pharmacology, 1979, Volume: 308, Issue:3 Topics: Animals; Gastrointestinal Motility; Hypophysectomy; Loperamide; Male; Morphine; Narcotics; Nociceptors; Rats; Species Specificity	1979
[Effects of loperamide on the gastric and intestinal motilities in the guinea pig and dog (author's transl)]. Nihon Heikatsukin Gakkai zasshi, 1977, Volume: 13, Issue:1 Topics: Animals; Atropine; Colon; Dogs; Gastrointestinal Motility; Guinea Pigs; Injections, Intravenous; Intestine, Small; Loperamide; Morphine; Piperidines	1977
[Pharmacological studies of loperamide, an anti-diarrheal agent. II. Effects on peristalsis of the small intestine and colon in guinea pigs (author's transl)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1978, Volume: 74, Issue:1 Topics: Animals; Atropine; Colon; Depression, Chemical; Dose-Response Relationship, Drug; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Intestine, Small; Loperamide; Male; Morphine; Peristalsis; Piperidines; Time Factors	1978
The effect of some anti-diarrhoeal drugs on intestinal transit and faecal excretion of water and electrolytes in the horse. Equine veterinary journal, 1978, Volume: 10, Issue:4 Topics: Animals; Antidiarrheals; Atropine; Electrolytes; Feces; Gastrointestinal Motility; Horses; Loperamide; Male; Meperidine; Morphine; Opium; Water	1978
Pharmacological evaluation of JO 1870: relation to the potential treatment of urinary bladder incontinence. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:3 Topics: Animals; Blood Pressure; Butylamines; Dimethylamines; Enkephalins; Guinea Pigs; In Vitro Techniques; Loperamide; Male; Morphine; Oxygen; Rats; Rats, Inbred Strains; Receptors, Opioid; Urinary Bladder; Urinary Incontinence	1992
Inhibitory effect of opiates on male rat sexual behavior may be mediated by opiate receptors outside the central nervous system. Psychopharmacology, 1992, Volume: 107, Issue:1 Topics: Analysis of Variance; Animals; Central Nervous System; Conditioning, Psychological; Ejaculation; Loperamide; Male; Morphine; Naloxone; Oxymorphone; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Sexual Behavior, Animal	1992
Loperamide but not morphine has anti-secretory effects in human colon, in vitro. European journal of pharmacology, 1991, Sep-17, Volume: 202, Issue:2 Topics: Colon; Electric Stimulation; Humans; In Vitro Techniques; Intestinal Mucosa; Loperamide; Morphine; Muscle, Smooth; Norepinephrine	1991
Effects of selective opioid agonists on feline colonic transit. Life sciences, 1991, Volume: 48, Issue:16 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cattle; Colon; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gastrointestinal Motility; Loperamide; Morphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1991
Small intestinal amyogenesia and dysmyogenesia induced by morphine and loperamide. The American journal of physiology, 1990, Volume: 258, Issue:2 Pt 1 Topics: Animals; Atropine; Dogs; Female; Gastrointestinal Motility; Hexamethonium; Hexamethonium Compounds; Intestine, Small; Loperamide; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Piperidines	1990
Novel calmodulin antagonist CGS 9343B inhibits secretory diarrhea. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 251, Issue:1 Topics: Analgesics; Animals; Antidiarrheals; Benzimidazoles; Calmodulin; Chlorpromazine; Gastrointestinal Transit; Loperamide; Male; Mice; Mice, Inbred ICR; Morphine; Rats; Rats, Inbred Strains	1989
Central vs. peripheral mediation of opioid effects on alcohol consumption in free-feeding rats. Pharmacology, biochemistry, and behavior, 1989, Volume: 33, Issue:2 Topics: Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Drinking Behavior; Drug Interactions; Loperamide; Male; Morphine; Naltrexone; Narcotic Antagonists; Piperidines; Polysorbates; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Time Factors	1989
Opioid and non-opioid actions of loperamide on cholinergic nerve function in human isolated colon. European journal of pharmacology, 1988, Jul-26, Volume: 152, Issue:1-2 Topics: Acetylcholine; Action Potentials; Calcium; Colon; Humans; In Vitro Techniques; Loperamide; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Parasympathetic Nervous System; Piperidines; Receptors, Opioid	1988
Action of loperamide on neuronally mediated and Ca2+- or cAMP-mediated secretion in rat colon. European journal of pharmacology, 1988, Aug-02, Volume: 152, Issue:3 Topics: Animals; Calcium; Carbachol; Colforsin; Colon; Cyclic AMP; Electric Stimulation; In Vitro Techniques; Intestinal Mucosa; Loperamide; Male; Morphine; Neurons; Piperidines; Rats; Rats, Inbred Strains; Trifluoperazine; Verapamil	1988
Evidence for a peripheral action of thyrotropin releasing hormone on gastrointestinal transit in mice. Neuropharmacology, 1988, Volume: 27, Issue:4 Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Drug Synergism; Gastrointestinal Transit; Loperamide; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Thiazolidines; Thyrotropin-Releasing Hormone	1988
Role of opioid receptors in stress induced gastric ulceration in rats. The Indian journal of medical research, 1986, Volume: 83 Topics: Animals; Female; Loperamide; Male; Morphine; Naloxone; Rats; Receptors, Opioid; Stomach Ulcer; Stress, Physiological	1986
Stress- and morphine-induced elevations of plasma and tissue cholesterol in mice: reversal by naltrexone. Biochemical pharmacology, 1988, Oct-01, Volume: 37, Issue:19 Topics: Animals; Aorta; Cholesterol; Female; Liver; Loperamide; Mice; Morphine; Naltrexone; Receptors, LDL; Stress, Physiological	1988
The influence of morphine, loperamide and naloxone on gallbladder response to prostaglandin E2 in the anaesthetized cat. Acta physiologica Scandinavica, 1986, Volume: 127, Issue:3 Topics: Animals; Cats; Cholecystitis; Dinoprostone; Female; Gallbladder; Loperamide; Male; Morphine; Muscle Contraction; Naloxone; Perfusion; Piperidines; Prostaglandins E; Water-Electrolyte Balance	1986
Inhibitory actions of loperamide on absorptive processes in rat small intestine. Gut, 1986, Volume: 27, Issue:6 Topics: Animals; Biological Transport; Body Fluids; Fructose; Galactose; Glycine; In Vitro Techniques; Intestinal Absorption; Intestine, Small; Kinetics; Loperamide; Male; Membrane Potentials; Morphine; Piperidines; Rats	1986
Progress report from the NIDA Addiction Research Center (preclinical laboratory), Lexington, Kentucky (1984). NIDA research monograph, 1984, Volume: 55 Topics: Aging; Animals; Behavior, Animal; beta-Endorphin; Cats; Cocaine; Discrimination Learning; Dogs; Endorphins; Humans; Loperamide; Morphine; National Institutes of Health (U.S.); Norbornanes; Pupil; Rats; Reinforcement, Psychology; Substance-Related Disorders; United States	1984
A micro-computerised system to measure the colonic contractile activity: application to pharmacological tests in dogs. International journal of bio-medical computing, 1980, Volume: 11, Issue:5 Topics: Animals; Atropine; Computers; Dogs; Electrophysiology; Gastrointestinal Motility; Intestines; Loperamide; Microcomputers; Morphine; Muscle Contraction; Nalorphine; Naloxone; Pyrrolidines	1980
Loperamide: evidence of interaction with mu and delta opioid receptors. Life sciences, 1983, Volume: 33 Suppl 1 Topics: Animals; Female; Guinea Pigs; Ileum; Loperamide; Male; Mice; Morphine; Muscle Contraction; Myenteric Plexus; Piperidines; Rabbits; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens	1983
Antisecretory activity of opiates in vitro and in vivo in man. Scandinavian journal of gastroenterology. Supplement, 1983, Volume: 84 Topics: Animals; Chlorides; Diarrhea; Dinoprostone; Humans; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Loperamide; Morphine; Piperidines; Prostaglandins E; Rabbits; Time Factors; Toxins, Biological	1983
The role of opioids in feeding and reward elicited by lateral hypothalamic electrical stimulation. Life sciences, 1983, Volume: 33 Suppl 1 Topics: Animals; Electric Stimulation; Feeding Behavior; Hypothalamus; Loperamide; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Reward	1983
A semichronic diarrheal model. Journal of pharmacological methods, 1982, Volume: 7, Issue:2 Topics: Animals; Chronic Disease; Diarrhea; Dietary Carbohydrates; Diphenoxylate; Disease Models, Animal; Female; Lactose; Loperamide; Male; Morphine; Rats; Rats, Inbred Strains; Sex Factors; Species Specificity	1982
Subcutaneous morphine reduces intestinal propulsion in rats partly by a central action. European journal of pharmacology, 1981, Nov-05, Volume: 75, Issue:4 Topics: Animals; Brain; Depression, Chemical; Drug Interactions; Female; Gastrointestinal Motility; Injections, Intraventricular; Injections, Subcutaneous; Loperamide; Morphine; Nalorphine; Rats; Rats, Inbred Strains	1981
Opioids and sexual behavior in the male rabbit: the role of central and peripheral opioid receptors. Journal of neural transmission. General section, 1994, Volume: 97, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Central Nervous System; Dose-Response Relationship, Drug; Ejaculation; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Loperamide; Male; Morphine; Naloxone; Narcotics; Oxymorphone; Peripheral Nervous System; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Sexual Behavior, Animal	1994
Absence of emetic effects of morphine and loperamide in Suncus murinus. European journal of pharmacology, 1994, May-02, Volume: 256, Issue:3 Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Loperamide; Male; Morphine; Naloxone; Nicotine; Serotonin; Serotonin Antagonists; Shrews; Vomiting	1994
Loperamide inhibits corticotrophic cell function by a naloxone-insensitive mechanism in the rat in vitro. Neuroendocrinology, 1993, Volume: 57, Issue:6 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Adrenocorticotropic Hormone; Animals; Calcium; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Loperamide; Male; Morphine; Naloxone; Phosphatidylinositols; Pituitary Gland, Anterior; Pro-Opiomelanocortin; Radioimmunoassay; Rats; Rats, Sprague-Dawley; RNA, Messenger; Second Messenger Systems	1993
Difenoxin and loperamide: studies on possible mechanisms of intestinal antisecretory action. Naunyn-Schmiedeberg's archives of pharmacology, 1993, Volume: 347, Issue:2 Topics: Animals; Antidiarrheals; Diphenoxylate; Dose-Response Relationship, Drug; Drug Interactions; Female; Intestinal Absorption; Jejunum; Loperamide; Male; Models, Biological; Morphine; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid; Serotonin; Serotonin Antagonists; Vasoactive Intestinal Peptide	1993
The peristaltic reflex in the rat ileum: evidence for functional mu- and delta-opiate receptors. The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:8 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antidiarrheals; Diphenoxylate; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ileum; Linear Models; Loperamide; Morphine; Peristalsis; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu	1995
Effects of opioids on the absorption of alcohol. Pharmacology, biochemistry, and behavior, 1997, Volume: 58, Issue:1 Topics: Analgesics, Opioid; Animals; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Gastrointestinal Agents; Injections, Intraperitoneal; Injections, Subcutaneous; Intestinal Absorption; Loperamide; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Wistar	1997
Peripheral effects of opioids in a model of chronic intestinal inflammation in mice. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:3 Topics: Animals; Antidiarrheals; Body Weight; Carbon Monoxide; Enteritis; Gastrointestinal Transit; Jejunum; Loperamide; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid	1998
Characterization of the antihyperalgesic action of a novel peripheral mu-opioid receptor agonist--loperamide. Anesthesiology, 1999, Volume: 90, Issue:1 Topics: Analgesics; Analgesics, Opioid; Animals; Burns; Drug Tolerance; Hindlimb; Hyperalgesia; Loperamide; Male; Morphine; Naloxone; Narcotic Antagonists; Nociceptors; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu	1999
Comparison of the peripheral and central effects of the opioid agonists loperamide and morphine in the formalin test in rats. Neuropharmacology, 2002, Volume: 42, Issue:2 Topics: Analgesics, Opioid; Animals; Antidiarrheals; Cisterna Magna; Dose-Response Relationship, Drug; Formaldehyde; Injections; Injections, Subcutaneous; Loperamide; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2002
Spinal and peripheral mu opioids and the development of secondary tactile allodynia after thermal injury. Anesthesia and analgesia, 2002, Volume: 94, Issue:4 Topics: Administration, Topical; Analgesics, Opioid; Animals; Burns; Hindlimb; Hyperalgesia; Injections, Spinal; Loperamide; Male; Morphine; Naloxone; Narcotic Antagonists; Neural Pathways; Neurons, Afferent; Pain Threshold; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Remifentanil; Spinal Cord; Touch	2002
Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein. Anesthesiology, 2002, Volume: 96, Issue:4 Topics: Alfentanil; Analgesics, Opioid; Animals; Antidiarrheals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Dose-Response Relationship, Drug; Fentanyl; Humans; Loperamide; Morphine; Sufentanil	2002
Morphine and d-amphetamine nullify each others' hypothermic effects in mice. Pharmacology & toxicology, 2003, Volume: 92, Issue:2 Topics: Analgesics, Opioid; Animals; Dextroamphetamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Antagonism; Fentanyl; Haloperidol; Hypothermia; Loperamide; Male; Mice; Morphine; Narcotic Antagonists; Receptors, Opioid; Sufentanil; Time Factors	2003
Peripheral opioids act as analgesics in bone cancer pain in mice. Neuroreport, 2003, May-06, Volume: 14, Issue:6 Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Cell Culture Techniques; Hyperalgesia; Loperamide; Mice; Mice, Inbred C3H; Morphine; Naloxone; Narcotic Antagonists; Osteosarcoma; Pain; Quaternary Ammonium Compounds	2003
Nociceptive sensitivity and opioid antinociception and antihyperalgesia in Freund's adjuvant-induced arthritic male and female rats. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:1 Topics: Analgesics, Opioid; Animals; Arthritis, Experimental; Body Weight; Butorphanol; Dose-Response Relationship, Drug; Estrous Cycle; Female; Foot; Freund's Adjuvant; Hyperalgesia; Loperamide; Male; Morphine; Naloxone; Narcotic Antagonists; Nociceptors; Oxycodone; Pain Measurement; Pressure; Rats; Rats, Inbred Lew; Sex Characteristics	2005
Acute analgesic effect of loperamide as compared to morphine after intrathecal administration in rat. Indian journal of experimental biology, 2005, Volume: 43, Issue:5 Topics: Analgesics; Animals; Injections, Spinal; Loperamide; Male; Morphine; Rats; Rats, Wistar	2005
Analgesic effects of morphine and loperamide in the rat formalin test: interactions with NMDA receptor antagonists. European journal of pharmacology, 2005, Nov-21, Volume: 525, Issue:1-3 Topics: Analgesics, Opioid; Animals; Excitatory Amino Acid Antagonists; Formaldehyde; Hot Temperature; Loperamide; Male; Morphine; Motor Skills; Narcotic Antagonists; Pain; Pain Measurement; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid	2005
Investigation on the relationship between cannabinoid CB1 and opioid receptors in gastrointestinal motility in mice. British journal of pharmacology, 2006, Volume: 148, Issue:8 Topics: Animals; Gastrointestinal Motility; Loperamide; Mice; Mice, Knockout; Morphine; Receptor, Cannabinoid, CB1; Receptors, Opioid	2006
Effects of loperamide on mechanical allodynia induced by herpes simplex virus type-1 in mice. Journal of pharmacological sciences, 2007, Volume: 104, Issue:3 Topics: Analgesics, Opioid; Animals; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Tolerance; Female; Foot; Herpes Simplex; Herpesvirus 1, Human; Injections; Injections, Subcutaneous; Loperamide; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Physical Stimulation	2007
Validation of 13C-acetic acid breath test by measuring effects of loperamide, morphine, mosapride, and itopride on gastric emptying in mice. Biological & pharmaceutical bulletin, 2008, Volume: 31, Issue:10 Topics: Acetic Acid; Analgesics, Opioid; Animals; Anti-Ulcer Agents; Antidiarrheals; Antiemetics; Benzamides; Benzyl Compounds; Breath Tests; Coloring Agents; Gastric Emptying; Loperamide; Male; Mice; Morphine; Morpholines; Naloxone; Narcotic Antagonists; Phenolsulfonphthalein; Reproducibility of Results	2008
Hypothesis on reciprocal interactions between the central and peripheral components of the endogenous opioid system. Bulletin of experimental biology and medicine, 2008, Volume: 146, Issue:6 Topics: Analgesics, Opioid; Animals; Drug Tolerance; Loperamide; Male; Morphine; Narcotic Antagonists; Oxymorphone; Pain Threshold; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, mu	2008
Assessment of the aversive effects of peripheral mu opioid receptor agonism in Fischer 344 and Lewis rats. Pharmacology, biochemistry, and behavior, 2012, Volume: 101, Issue:2 Topics: Animals; Avoidance Learning; Conditioning, Psychological; Dose-Response Relationship, Drug; Loperamide; Male; Morphine; Rats; Rats, Inbred F344; Rats, Inbred Lew; Receptors, Opioid, mu; Species Specificity; Taste	2012
Dissecting the relative contribution of central versus peripheral opioid analgesia: are the analgesic and adverse effects of opioids inseparable? European journal of pain (London, England), 2012, Volume: 16, Issue:5 Topics: Analgesics, Opioid; Animals; Fentanyl; Loperamide; Male; Morphine; Pain; Receptors, Opioid; Spinal Cord	2012
Relative contributions of peripheral versus supraspinal or spinal opioid receptors to the antinociception of systemic opioids. European journal of pain (London, England), 2012, Volume: 16, Issue:5 Topics: Analgesics, Opioid; Animals; Fentanyl; Inflammation; Loperamide; Male; Morphine; Pain; Rats; Rats, Wistar; Receptors, Opioid; Sensory Receptor Cells; Spinal Cord	2012
Antinociceptive effect of intrathecal loperamide: role of mu-opioid receptor and calcium channels. European journal of pharmacology, 2012, Dec-05, Volume: 696, Issue:1-3 Topics: Analgesics; Animals; Behavior, Animal; Calcium Channels; Hot Temperature; Injections, Spinal; Loperamide; Male; Morphine; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu	2012
A facile synthesis for novel loperamide analogs as potential μ opioid receptor agonists. Molecules (Basel, Switzerland), 2012, Dec-03, Volume: 17, Issue:12 Topics: Humans; Ligands; Loperamide; Molecular Structure; Morphine; Piperidines; Receptors, Opioid, mu; Structure-Activity Relationship	2012
Mu-Opioid Receptors in Ganglia, But Not in Muscle, Mediate Peripheral Analgesia in Rat Muscle Pain. Anesthesia and analgesia, 2018, Volume: 126, Issue:4 Topics: Acute Pain; Analgesics; Animals; Disease Models, Animal; Facial Pain; Ganglia, Spinal; Loperamide; Male; Morphine; Muscle, Skeletal; Myalgia; Rats, Wistar; Receptors, Opioid, mu; Trigeminal Ganglion	2018
Suppression of Human Natural Killer Cells by Different Classes of Opioids. Anesthesia and analgesia, 2019, Volume: 128, Issue:5 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Anesthesia; Buprenorphine; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Fluoresceins; Humans; Immunosuppression Therapy; K562 Cells; Killer Cells, Natural; Loperamide; Methadone; Morphinans; Morphine; Naloxone; Naltrexone; Succinimides; Toll-Like Receptor 4; Tramadol	2019