loperamide and haloperidol

loperamide has been researched along with haloperidol in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.55)18.7374
1990's2 (9.09)18.2507
2000's6 (27.27)29.6817
2010's11 (50.00)24.3611
2020's2 (9.09)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Booth, RG; Brown, RL; Bucholtz, EC; Tropsha, A; Wyrick, SD1
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Ang, KK; Arkin, MR; Chen, S; Doyle, PS; Engel, JC; McKerrow, JH1
Chen, X; Lin, X; Skolnik, S; Wang, J1
Brouillette, WJ; Brown, GB; Zha, C1
Artursson, P; Mateus, A; Matsson, P1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Mol, CA; Schinkel, AH; van Deemter, L; Wagenaar, E1
Baker, A; Meert, T1
Kalgutkar, AS; Nguyen, HT1
Major, F; Rupnik, M; Tietze, LF; Yang, SB1
Jensen, H; Kostiainen, R; Kotiaho, T; Pedersen-Bjergaard, S; Rasmussen, KE; Sikanen, T1
Baig, AM; Iqbal, J; Khan, NA1
Hansen, SH; Jensen, H; Li, B; Payán, MD; Pedersen-Bjergaard, S; Petersen, NJ1
Baig, AM; Khan, NA1
Baig, AM; Khan, NA; Kulsoom, H; Siddiqui, R1
Dvořák, M; Kubáň, P; Miková, B; Ryšavá, L1

Reviews

1 review(s) available for loperamide and haloperidol

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

21 other study(ies) available for loperamide and haloperidol

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.
    Journal of medicinal chemistry, 1999, Aug-12, Volume: 42, Issue:16

    Topics: Animals; Binding Sites; Binding, Competitive; Brain; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ligands; Models, Molecular; Pyrilamine; Radioligand Assay; Structure-Activity Relationship; Tetrahydronaphthalenes

1999
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
    Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11

    Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:8

    Topics: Animals; Cattle; Cell Line; Cell Line, Tumor; Chagas Disease; Drug Evaluation, Preclinical; Hepatocytes; High-Throughput Screening Assays; Humans; Image Processing, Computer-Assisted; Muscle, Skeletal; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi

2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2

    Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity

2011
A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands.
    Bioorganic & medicinal chemistry, 2014, Jan-01, Volume: 22, Issue:1

    Topics: Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Voltage-Gated Sodium Channels

2014
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
    Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7

    Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2014
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.
    The Journal of clinical investigation, 1996, Jun-01, Volume: 97, Issue:11

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Cell Line; Clozapine; Diffusion; Domperidone; Epithelium; Flunitrazepam; Haloperidol; Humans; Kidney; Kinetics; Loperamide; Male; Mice; Mice, Inbred Strains; Ondansetron; Phenytoin; Recombinant Proteins; Structure-Activity Relationship; Swine; Tissue Distribution; Transfection

1996
Morphine and d-amphetamine nullify each others' hypothermic effects in mice.
    Pharmacology & toxicology, 2003, Volume: 92, Issue:2

    Topics: Analgesics, Opioid; Animals; Dextroamphetamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Antagonism; Fentanyl; Haloperidol; Hypothermia; Loperamide; Male; Mice; Morphine; Narcotic Antagonists; Receptors, Opioid; Sufentanil; Time Factors

2003
Identification of an N-methyl-4-phenylpyridinium-like metabolite of the antidiarrheal agent loperamide in human liver microsomes: underlying reason(s) for the lack of neurotoxicity despite the bioactivation event.
    Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:9

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Antidiarrheals; Bupropion; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dealkylation; Haloperidol; Humans; Hydroxylation; Ketoconazole; Loperamide; Male; Microsomes, Liver; NADP; Neurons; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Time Factors

2004
Block of delayed-rectifier potassium channels by reduced haloperidol and related compounds in mouse cortical neurons.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 315, Issue:1

    Topics: Animals; Binding Sites; Cerebral Cortex; Female; Haloperidol; Loperamide; Mice; Mice, Inbred C57BL; Neurons; Oxidation-Reduction; Potassium Channel Blockers

2005
Implementation of droplet-membrane-droplet liquid-phase microextraction under stagnant conditions for lab-on-a-chip applications.
    Analytica chimica acta, 2010, Jan-25, Volume: 658, Issue:2

    Topics: Carboxylic Acids; Electrophoresis, Capillary; Haloperidol; Humans; Hydrogen-Ion Concentration; Lab-On-A-Chip Devices; Lasers; Loperamide; Meperidine; Miniaturization; Nortriptyline; Octanols; Polypropylenes; Porphobilinogen; Spectrophotometry, Ultraviolet

2010
In vitro efficacies of clinically available drugs against growth and viability of an Acanthamoeba castellanii keratitis isolate belonging to the T4 genotype.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:8

    Topics: Acanthamoeba castellanii; Amlodipine; Antiprotozoal Agents; Culture Media; Digoxin; Drug Evaluation, Preclinical; Genotype; Haloperidol; Loperamide; Parasitic Sensitivity Tests; Prochlorperazine; Trophozoites

2013
Nano-electromembrane extraction.
    Analytica chimica acta, 2013, Jun-27, Volume: 785

    Topics: Electricity; Electrophoresis, Capillary; Ethers; Haloperidol; Loperamide; Membranes, Artificial; Meperidine; Methadone; Nanotechnology; Nortriptyline; Sodium Chloride; Solutions; Sulfates; Water

2013
Anesthesia with antiamoebic effects: can anesthesia choice affect the clinical outcome of granulomatous amoebic encephalitis due to Acanthamoeba spp.?
    Journal of neurosurgical anesthesiology, 2014, Volume: 26, Issue:4

    Topics: Acanthamoeba; Amebiasis; Anesthesia; Antipsychotic Agents; Drug Synergism; Encephalitis; Granuloma; Haloperidol; Humans; Loperamide

2014
Combined drug therapy in the management of granulomatous amoebic encephalitis due to Acanthamoeba spp., and Balamuthia mandrillaris.
    Experimental parasitology, 2014, Volume: 145 Suppl

    Topics: Acanthamoeba castellanii; Amebiasis; Amebicides; Amiodarone; Amlodipine; Apomorphine; Balamuthia mandrillaris; Brain; Cells, Cultured; Digoxin; Drug Synergism; Drug Therapy, Combination; Encephalitis; Endothelial Cells; Haloperidol; Humans; Loperamide; Microvessels; Prochlorperazine; Procyclidine

2014
Hollow Fiber Liquid-Phase Microextraction At-Line Coupled to Capillary Electrophoresis for Direct Analysis of Human Body Fluids.
    Analytical chemistry, 2020, 05-19, Volume: 92, Issue:10

    Topics: Body Fluids; Electrophoresis, Capillary; Haloperidol; Humans; Liquid Phase Microextraction; Loperamide; Nortriptyline; Papaverine; Particle Size; Porosity; Surface Properties

2020