loperamide and fluorouracil

loperamide has been researched along with fluorouracil in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (13.33)18.2507
2000's8 (53.33)29.6817
2010's4 (26.67)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Gozalbes, R; Pineda-Lucena, A1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Cascinu, S; Catalano, G; Fedeli, A; Fedeli, SL1
Droege, CM; Hausamen, TU; Lenfers, BH; Loeffler, TM1
Agostinelli, R; Amadori, D; Bichisao, E; Cascinu, S; Catalano, G; Catalano, V; Giordani, P; Luppi, G; Sansoni, E; Silingardi, V1
Brewster, M; Kempen, D; Peeters, J; Six, K; Van den Mooter, G; Verreck, G; Weuts, I1
Kullmann, F; Schölmerich, J; Schultz, M1
Jahnke, K; Keilholz, U; Schmittel, A; Thiel, E1
Bosron, WF; Davis, WI; Hurley, TD; Murry, DJ; Quinney, SK; Sanghani, SP; Sun, Z1
Benson, A; Wisinski, K1
Karaoglu, A; Topkan, E1
Andrade, AC; Barrios, CH; Chinen, RN; Correa, M; Coutinho, AK; del Giglio, A; Dutra, C; Forones, NM; Hoff, PM; Passos, VQ; Portella, Mdo S; Saragiotto, DF; van Eyll, B1

Reviews

1 review(s) available for loperamide and fluorouracil

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

5 trial(s) available for loperamide and fluorouracil

ArticleYear
Octreotide versus loperamide in the treatment of fluorouracil-induced diarrhea: a randomized trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1993, Volume: 11, Issue:1

    Topics: Adult; Aged; Diarrhea; Female; Fluorouracil; Humans; Loperamide; Male; Middle Aged; Octreotide

1993
Substantial activity of budesonide in patients with irinotecan (CPT-11) and 5-fluorouracil induced diarrhea and failure of loperamide treatment.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1999, Volume: 10, Issue:10

    Topics: Administration, Oral; Administration, Topical; Aged; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Budesonide; Camptothecin; Diarrhea; Female; Fluorouracil; Glucocorticoids; Humans; Irinotecan; Loperamide; Male; Middle Aged; Treatment Failure

1999
High-dose loperamide in the treatment of 5-fluorouracil-induced diarrhea in colorectal cancer patients.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2000, Volume: 8, Issue:1

    Topics: Administration, Oral; Adult; Aged; Antidiarrheals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Diarrhea; Female; Fluorouracil; Humans; Loperamide; Male; Middle Aged

2000
Octreotide in the management of chemoradiotherapy-induced diarrhea refractory to loperamide in patients with rectal carcinoma.
    Oncology, 2006, Volume: 71, Issue:5-6

    Topics: Adult; Aged; Antineoplastic Agents; Carcinoma; Combined Modality Therapy; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Female; Fluorouracil; Humans; Injections, Subcutaneous; Loperamide; Male; Middle Aged; Octreotide; Pilot Projects; Prospective Studies; Radiotherapy, Conformal; Rectal Neoplasms; Treatment Outcome

2006
Randomized phase III trial exploring the use of long-acting release octreotide in the prevention of chemotherapy-induced diarrhea in patients with colorectal cancer: the LARCID trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Apr-01, Volume: 32, Issue:10

    Topics: Adult; Aged; Antidiarrheals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Delayed-Action Preparations; Deoxycytidine; Diarrhea; Female; Fluorouracil; Humans; Irinotecan; Loperamide; Male; Middle Aged; Octreotide; Quality of Life; Severity of Illness Index; Young Adult

2014

Other Studies

9 other study(ies) available for loperamide and fluorouracil

ArticleYear
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
QSAR-based solubility model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19

    Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water

2010
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Evaluation of different calorimetric methods to determine the glass transition temperature and molecular mobility below T(g) for amorphous drugs.
    International journal of pharmaceutics, 2003, Jun-18, Volume: 259, Issue:1-2

    Topics: Azoles; Calorimetry, Differential Scanning; Chemical Phenomena; Chemistry, Physical; Drug Stability; Fluorouracil; Itraconazole; Ketoconazole; Loperamide; Miconazole; Polyesters; Temperature

2003
[Management of chemotherapy induced diarrhea].
    Zeitschrift fur Gastroenterologie, 2004, Volume: 42, Issue:6

    Topics: Antidiarrheals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Diarrhea; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Fluorouracil; Humans; Irinotecan; Loperamide; Neoplasms; Octreotide; Patient Care Management; Practice Guidelines as Topic

2004
Neomycin as secondary prophylaxis for irinotecan-induced diarrhea.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2004, Volume: 15, Issue:8

    Topics: Administration, Oral; Anti-Bacterial Agents; Antidiarrheals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Diarrhea; Fluorouracil; Humans; Irinotecan; Leucovorin; Loperamide; Neomycin

2004
Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:3

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Carboxylesterase; Deoxycytidine; Fluorouracil; Gastrointestinal Tract; Humans; Hydrolysis; Isoenzymes; Loperamide; Prodrugs

2005
Chemotherapy-induced mucositis: focusing on diarrhea.
    The journal of supportive oncology, 2007, Volume: 5, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Budesonide; Camptothecin; Dehydration; Diarrhea; Fluorouracil; Gastric Mucosa; Gastrointestinal Tract; Humans; Infusions, Intravenous; Intestinal Absorption; Intestinal Mucosa; Irinotecan; Leucovorin; Loperamide; Mice; Mucositis; Organoplatinum Compounds; Rats

2007