loperamide and digoxin

loperamide has been researched along with digoxin in 20 studies

Research

Studies (20)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	7 (35.00)	29.6817
2010's	12 (60.00)	24.3611
2020's	1 (5.00)	2.80

Authors

Authors	Studies
Adachi, Y; Sugiyama, Y; Suzuki, H	1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Byun, SY; Choi, I; Jeon, S; Kim, S; Ko, M; Lee, J; Park, S; Shum, D	1
Greenblatt, DJ; von Moltke, LL	1
Aungst, BJ; Fujita, H; Kobayashi, M; Matsubara, K; Saito, T; Saitoh, H; Suno, M; Yamaguchi, M	1
Acharya, P; Ayrton, A; Bentz, J; Ellens, H; O'Connor, MP; Polli, JW	1
Abraham, F; Acharya, P; Agnani, D; Bentz, J; Ellens, H; Martinez, E; Tobin, F; Tran, TT	1
Baig, AM; Iqbal, J; Khan, NA	1
Al-Jayyoussi, G; Eddershaw, P; Edwards, CD; Francombe, D; Gumbleton, M; Morris, C; Price, DF; Smith, MW; Taylor, G	1
Ahmed, Z; Bentz, J; Ellens, H; Hidalgo, IJ; Li, J; Li, L; Lumen, AA; Meng, Z; Owen, A	1
Baig, AM; Khan, NA; Kulsoom, H; Siddiqui, R	1
Akazawa, T; Ohtsuki, S; Tachikawa, M; Terasaki, T; Uchida, Y	1
Bentz, J; Ellens, H; Meng, Z	1

Reviews

2 review(s) available for loperamide and digoxin

Article	Year
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

18 other study(ies) available for loperamide and digoxin

Article	Year
Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharmaceutical research, 2001, Volume: 18, Issue:12 Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Caco-2 Cells; Cell Membrane Permeability; Dose-Response Relationship, Drug; Humans; Hydrolysis; LLC-PK1 Cells; Male; Mice; Mice, Knockout; Models, Biological; Pharmaceutical Preparations; Swine; Tissue Distribution; Transfection	2001
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrobial agents and chemotherapy, 2020, 06-23, Volume: 64, Issue:7 Topics: Animals; Anti-Inflammatory Agents; Antiviral Agents; Betacoronavirus; Cell Line; Chlorocebus aethiops; Coronavirus Infections; COVID-19; Drug Evaluation, Preclinical; Drug Repositioning; Humans; Niclosamide; Pandemics; Pneumonia, Viral; Pregnenediones; SARS-CoV-2; Vero Cells	2020
Drug transporters revisited. Journal of clinical psychopharmacology, 2001, Volume: 21, Issue:1 Topics: Animals; Antidiarrheals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Central Nervous System; Digoxin; Enzyme Inhibitors; Humans; Loperamide	2001
Relationship between loperamide-induced sedative effect and digoxin pharmacokinetics in healthy Japanese subjects. Pharmaceutical research, 2005, Volume: 22, Issue:3 Topics: Adult; Asian People; Digoxin; Female; Flicker Fusion; Humans; Hypnotics and Sedatives; Loperamide; Male; Sleep Stages	2005
Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbamates; Cell Line; Cell Membrane; Digoxin; Dogs; Furans; Kinetics; Loperamide; Quinidine; Sulfonamides	2008
Fitting the elementary rate constants of the P-gp transporter network in the hMDR1-MDCK confluent cell monolayer using a particle swarm algorithm. PloS one, 2011, Volume: 6, Issue:10 Topics: Adenosine Triphosphate; Algorithms; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carbamates; Cell Line; Digoxin; Dogs; Furans; Humans; Hydrolysis; Kinetics; Loperamide; Sulfonamides	2011
In vitro efficacies of clinically available drugs against growth and viability of an Acanthamoeba castellanii keratitis isolate belonging to the T4 genotype. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:8 Topics: Acanthamoeba castellanii; Amlodipine; Antiprotozoal Agents; Culture Media; Digoxin; Drug Evaluation, Preclinical; Genotype; Haloperidol; Loperamide; Parasitic Sensitivity Tests; Prochlorperazine; Trophozoites	2013
Selectivity in the impact of P-glycoprotein upon pulmonary absorption of airway-dosed substrates: a study in ex vivo lung models using chemical inhibition and genetic knockout. Journal of pharmaceutical sciences, 2013, Volume: 102, Issue:9 Topics: Animals; Anti-Arrhythmia Agents; Antidiarrheals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Sub-Family B Member 4; Biological Transport; Digoxin; Dogs; Gene Knockout Techniques; HIV Protease Inhibitors; Humans; Loperamide; Lung; Madin Darby Canine Kidney Cells; Male; Mice; Mice, Knockout; Permeability; Rats; Rats, Sprague-Dawley; Rhodamine 123; Saquinavir	2013
Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp. PloS one, 2013, Volume: 8, Issue:8 Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Carbamates; Cell Membrane Permeability; Cyclosporine; Digoxin; Dogs; Furans; Gene Expression; Humans; Ketoconazole; Kinetics; Loperamide; Madin Darby Canine Kidney Cells; Protein Binding; Quinidine; Sulfonamides; Tetrahydroisoquinolines; Vinblastine	2013
Combined drug therapy in the management of granulomatous amoebic encephalitis due to Acanthamoeba spp., and Balamuthia mandrillaris. Experimental parasitology, 2014, Volume: 145 Suppl Topics: Acanthamoeba castellanii; Amebiasis; Amebicides; Amiodarone; Amlodipine; Apomorphine; Balamuthia mandrillaris; Brain; Cells, Cultured; Digoxin; Drug Synergism; Drug Therapy, Combination; Encephalitis; Endothelial Cells; Haloperidol; Humans; Loperamide; Microvessels; Prochlorperazine; Procyclidine	2014
Quantitative Targeted Absolute Proteomics of Transporters and Pharmacoproteomics-Based Reconstruction of P-Glycoprotein Function in Mouse Small Intestine. Molecular pharmaceutics, 2016, 07-05, Volume: 13, Issue:7 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Dexamethasone; Digoxin; Duodenum; Ileum; Intestinal Absorption; Intestine, Small; Jejunum; Loperamide; Mice; Mice, Knockout; Proteomics; Quinidine; Verapamil; Vinblastine	2016
Extrapolation of Elementary Rate Constants of P-glycoprotein-Mediated Transport from MDCKII-hMDR1-NKI to Caco-2 Cells. Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Carbamates; Cell Culture Techniques; Cell Membrane; Cell Membrane Permeability; Digoxin; Dogs; Furans; Humans; Kinetics; Loperamide; Madin Darby Canine Kidney Cells; Models, Biological; Quinidine; Sulfonamides	2017