Page last updated: 2024-09-04

lonafarnib and tipifarnib

lonafarnib has been researched along with tipifarnib in 38 studies

Compound Research Comparison

Studies
(lonafarnib)
Trials
(lonafarnib)
Recent Studies (post-2010)
(lonafarnib)
Studies
(tipifarnib)
Trials
(tipifarnib)
Recent Studies (post-2010) (tipifarnib)
6033099294
22434903099294

Protein Interaction Comparison

ProteinTaxonomylonafarnib (IC50)tipifarnib (IC50)
Chain B, Protein farnesyltransferase beta subunitRattus norvegicus (Norway rat)0.0007
Cytochrome P450 3A4Homo sapiens (human)2.88
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaBos taurus (cattle)0.5503
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaHomo sapiens (human)2.2237
Protein farnesyltransferase subunit betaBos taurus (cattle)0.0006
Protein farnesyltransferase subunit betaHomo sapiens (human)0.0019
Geranylgeranyl transferase type-1 subunit betaHomo sapiens (human)10
Geranylgeranyl transferase type-1 subunit betaBos taurus (cattle)1.1
Protein farnesyltransferase alpha subunitPlasmodium falciparum (malaria parasite P. falciparum)0.017
CAAX farnesyltransferase subunit beta Plasmodium falciparum (malaria parasite P. falciparum)0.017

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's30 (78.95)29.6817
2010's6 (15.79)24.3611
2020's2 (5.26)2.80

Authors

AuthorsStudies
Claiborne, A; Cohen, J; Frost, D; Gu, WZ; Hutchins, C; Li, Q; Lin, NH; Rosenberg, SH; Sham, HL; Stoll, VS; Wang, W; Woods, KW1
Cohen, J; Frost, D; Galicia, T; Gu, WZ; Hutchins, C; Li, Q; Li, T; Rosenberg, SH; Sham, HL; Stoll, VS; Woods, KW1
Cohen, J; Curtin, ML; Florjancic, AS; Frost, DJ; Gu, WZ; Muchmore, SW; Sham, HL1
Bauch, JL; Cohen, J; Gu, WZ; Hutchins, CW; Jakob, CG; Leonard, NM; Li, Q; Lin, NH; Marsh, K; Park, D; Rosenberg, SH; Sham, HL; Stoll, VS; Sullivan, G; Tong, Y; Wang, GT; Wang, L; Wang, X; Zhang, H1
Bell, IM1
Claiborne, A; Cohen, J; Frost, D; Gu, W; Hasvold, L; Hutchins, C; Jakob, CG; Li, Q; Li, T; Muchmore, S; Rosenberg, SH; Sham, HL; Stoll, VS1
Bauer, KD; Bendale, P; Buckner, FS; Chakrabarti, D; Floyd, D; Gelb, MH; Hamilton, A; Hornéy, CP; Lombardo, LJ; Nallan, L; Pendyala, PR; Rivas, K; Sebti, S; Van Voorhis, WC; Weber, PC; Williams, DK; Windsor, WT; Yokoyama, K1
Brunsveld, L; Gelb, MH; Hrycyna, CA; Michaelis, S; Tamanoi, F; Van Voorhis, WC; Waldmann, H1
Bonovolias, ID; Chatzopoulou, M; Demopoulos, VJ; Nicolaou, I; Tsiftsoglou, AS; Vizirianakis, IS1
Distefano, MD; Ochocki, JD1
Buuh, ZY; Lyu, Z; Wang, RE1
Korzeniecki, C; Priefer, R1
Adjei, AA; End, DW; Karp, JE; Kaufmann, SH; Lancet, JE; Wright, JJ1
Bernhard, E; Hahn, SM; McKenna, WG1
Adjei, AA; Dy, GK; Haluska, P1
Dancey, JE1
Caponigro, F1
Adjei, AA; Dy, GK1
Baum, C; Kirschmeier, P1
Kelland, LR1
Cortes, J1
de Bono, JS; Rowinsky, EK; Tolcher, AW1
Tauchi, T1
Cortes, J; Jabbour, E; Kantarjian, H1
Helbig, G; Hołowiecki, J1
Elhamri, M; Thomas, X1
Abbruzzese, A; Budillon, A; Caponigro, F; Caraglia, M; Marra, M; Tagliaferri, P1
Feldman, EJ2
Appels, NM; Beijnen, JH; Schellens, JH1
Jiang, D; Zhang, M1
Harousseau, JL1
Berk, S; Gajewski, TF; Ho, AW; Kuna, T; Marks, RE; Robbel, C1
Le Moulec, S; Loriot, Y; Soria, JC1
Li, M; Liu, A; Liu, B; Luo, X; Yu, H; Zheng, H1
Crovella, S; De Leo, L; Decorti, G; Marcuzzi, A; Pontillo, A; Tommasini, A1
Fernandes, PA; Moorthy, NS; Ramos, MJ; Sousa, SF1
Eşkazan, AE; Özgür Yurttaş, N1

Reviews

25 review(s) available for lonafarnib and tipifarnib

ArticleYear
Inhibitors of farnesyltransferase: a rational approach to cancer chemotherapy?
    Journal of medicinal chemistry, 2004, Apr-08, Volume: 47, Issue:8

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Drug Design; Farnesyltranstransferase; Genes, ras; Humans; Neoplasms

2004
Therapeutic intervention based on protein prenylation and associated modifications.
    Nature chemical biology, 2006, Volume: 2, Issue:10

    Topics: Animals; Antineoplastic Agents; Humans; Models, Molecular; Molecular Conformation; Progeria; Protein Prenylation; Proteins

2006
Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives.
    Journal of medicinal chemistry, 2010, Oct-14, Volume: 53, Issue:19

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Differentiation; Clinical Trials as Topic; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Leukemia; Multipotent Stem Cells; Neoplastic Stem Cells; Pharmacogenetics

2010
Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins.
    Journal of medicinal chemistry, 2018, 04-26, Volume: 61, Issue:8

    Topics: Acetylation; Animals; Citrullination; Enzyme Inhibitors; Glycosylation; Humans; Methylation; Phosphorylation; Protein Prenylation; Protein Processing, Post-Translational; Proteins; Ubiquitination

2018
Targeting KRAS mutant cancers by preventing signaling transduction in the MAPK pathway.
    European journal of medicinal chemistry, 2021, Feb-05, Volume: 211

    Topics: Humans; Models, Molecular; Molecular Structure; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Signal Transduction

2021
Current status of clinical trials of farnesyltransferase inhibitors.
    Current opinion in oncology, 2001, Volume: 13, Issue:6

    Topics: Alkyl and Aryl Transferases; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Leukemia; Neoplasms; Piperidines; Pyridines; Quinolones; Signal Transduction

2001
Farnesyltransferase inhibitors.
    Seminars in oncology, 2001, Volume: 28, Issue:5 Suppl 16

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Benzodiazepines; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Imidazoles; Piperidines; Pyridines; Quinolones; ras Proteins

2001
Farnesyl transferase inhibitors as anticancer agents.
    European journal of cancer (Oxford, England : 1990), 2002, Volume: 38, Issue:13

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Benzodiazepines; Cell Division; Clinical Trials as Topic; Combined Modality Therapy; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; Humans; Imidazoles; Neoplasms; Piperidines; Pyridines; Quinolones; Tumor Cells, Cultured

2002
Agents targeting ras signaling pathway.
    Current pharmaceutical design, 2002, Volume: 8, Issue:25

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Benzamides; Benzodiazepines; Enzyme Inhibitors; Farnesyltranstransferase; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Imidazoles; MAP Kinase Kinase Kinases; Oligonucleotides, Antisense; Phosphorothioate Oligonucleotides; Piperidines; Proto-Oncogene Proteins c-raf; Pyridines; Quinolones; Signal Transduction

2002
Farnesyltransferase inhibitors in breast cancer therapy.
    Cancer investigation, 2002, Volume: 20 Suppl 2

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Clinical Trials as Topic; Deoxycytidine; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Farnesyltranstransferase; Female; Fluorouracil; Humans; Mice; Neoplasm Proteins; Paclitaxel; Piperidines; Protein Prenylation; Protein Processing, Post-Translational; Pyridines; Quinolones; Signal Transduction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2002
Preclinical and clinical evaluation of farnesyltransferase inhibitors.
    Current oncology reports, 2003, Volume: 5, Issue:2

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Benzodiazepines; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; Humans; Imidazoles; Piperidines; Pyridines; Quinolones

2003
Farnesyl transferase inhibitors in the treatment of breast cancer.
    Expert opinion on investigational drugs, 2003, Volume: 12, Issue:3

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Benzodiazepines; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Female; Humans; Imidazoles; Piperidines; Pyridines; Quinolones; ras Proteins

2003
Farnesyltransferase inhibitors and their potential in the treatment of breast carcinoma.
    Seminars in oncology, 2003, Volume: 30, Issue:5 Suppl 16

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; Humans; Piperidines; Protein Prenylation; Proto-Oncogene Mas; Pyridines; Quinolones; ras Proteins; Signal Transduction

2003
[Molecular pathogenesis of chronic myeloid leukemia and tyrosine kinase inhibitor].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2004, Volume: 45, Issue:1

    Topics: Animals; Benzamides; Chromosome Aberrations; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Hematopoietic Stem Cell Transplantation; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Piperazines; Piperidines; Pyridines; Pyrimidines; Quinolones; Randomized Controlled Trials as Topic; Thionucleotides

2004
Clinical activity of farnesyl transferase inhibitors in hematologic malignancies: possible mechanisms of action.
    Leukemia & lymphoma, 2004, Volume: 45, Issue:11

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Benzodiazepines; Cell Line, Tumor; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Hematologic Neoplasms; Humans; Imidazoles; Piperidines; Pyridines; Quinolones; ras Proteins; Signal Transduction

2004
[Ras signaling pathway as a target for farnesyltransferase inhibitors--a new, promising prospects in the treatment for malignant disorders].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 2004, Volume: 57, Issue:9-10

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Farnesyltranstransferase; Genes, ras; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Imidazoles; Neoplasms; Piperidines; Point Mutation; Pyridines; Quinolones; Signal Transduction

2004
[Farnesyltransferase inhibitors: preliminary results in acute myeloid leukemia].
    Bulletin du cancer, 2005, Volume: 92, Issue:3

    Topics: Alkyl and Aryl Transferases; Benzodiazepines; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Drug Resistance, Neoplasm; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Imidazoles; Leukemia, Myeloid, Acute; Mitogen-Activated Protein Kinase 1; Myeloproliferative Disorders; Piperidines; Protein Prenylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Quinolones; ras Proteins; rho GTP-Binding Proteins

2005
Isoprenylation of intracellular proteins as a new target for the therapy of human neoplasms: preclinical and clinical implications.
    Current drug targets, 2005, Volume: 6, Issue:3

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Benzodiazepines; Farnesyltranstransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Mevalonic Acid; Neoplasms; Phosphatidylinositol 3-Kinases; Piperidines; Protein Prenylation; Protein Processing, Post-Translational; Pyridines; Quinolones; ras Proteins

2005
Farnesyltransferase inhibitors in myelodysplastic syndrome.
    Current hematology reports, 2005, Volume: 4, Issue:3

    Topics: Acute Disease; Aged; Alkyl and Aryl Transferases; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Disease Progression; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; Hematologic Neoplasms; Humans; Leukemia, Myeloid; Middle Aged; Myelodysplastic Syndromes; Piperidines; Protein Prenylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Pyridines; Quinolones; Remission Induction; Signal Transduction; Treatment Outcome

2005
Development of farnesyl transferase inhibitors: a review.
    The oncologist, 2005, Volume: 10, Issue:8

    Topics: Animals; Antineoplastic Agents; Benzodiazepines; Clinical Trials as Topic; Drug Design; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Imidazoles; Piperidines; Pyridines; Quinolones; ras Proteins

2005
[Farnesyl transferase inhibitors--a novel agent for breast cancer].
    Ai zheng = Aizheng = Chinese journal of cancer, 2006, Volume: 25, Issue:4

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Enzyme Inhibitors; Farnesyltranstransferase; Female; Genes, ras; Humans; Piperidines; Protein Prenylation; Pyridines; Quinolones; ras Proteins

2006
Farnesyltransferase inihibitors in hematologic malignancies.
    Blood reviews, 2007, Volume: 21, Issue:4

    Topics: Antineoplastic Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Hematologic Neoplasms; Humans; Piperidines; Pyridines; Quinolones; Signal Transduction

2007
Farnesyltransferase inhibitors in myelodysplastic syndrome.
    Current hematologic malignancy reports, 2006, Volume: 1, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Bone Marrow Diseases; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Disease Progression; Farnesyltranstransferase; Gastrointestinal Diseases; Genes, ras; Hematologic Neoplasms; Humans; Middle Aged; Myelodysplastic Syndromes; Piperidines; Prenylation; Protein Processing, Post-Translational; Pyridines; Quinolones; Treatment Outcome

2006
Farnesyltransferase inhibitors: a comprehensive review based on quantitative structural analysis.
    Current medicinal chemistry, 2013, Volume: 20, Issue:38

    Topics: Antineoplastic Agents; Biological Products; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Neoplasms; Piperidines; Pyridines; Quantitative Structure-Activity Relationship; Quinolones

2013
Novel therapeutic approaches in chronic myeloid leukemia.
    Leukemia research, 2020, Volume: 91

    Topics: Antineoplastic Agents; Clinical Trials as Topic; Drug Resistance, Neoplasm; Everolimus; Fusion Proteins, bcr-abl; Gene Expression; Histone Deacetylase Inhibitors; Homoharringtonine; Humans; Immunotherapy; Interferon-alpha; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Targeted Therapy; Niacinamide; Piperidines; Polyethylene Glycols; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Quinolones; Recombinant Proteins

2020

Trials

1 trial(s) available for lonafarnib and tipifarnib

ArticleYear
[Farnesyl transferase inhibitors--a novel agent for breast cancer].
    Ai zheng = Aizheng = Chinese journal of cancer, 2006, Volume: 25, Issue:4

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Enzyme Inhibitors; Farnesyltranstransferase; Female; Genes, ras; Humans; Piperidines; Protein Prenylation; Pyridines; Quinolones; ras Proteins

2006

Other Studies

13 other study(ies) available for lonafarnib and tipifarnib

ArticleYear
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.
    Bioorganic & medicinal chemistry letters, 2005, Apr-15, Volume: 15, Issue:8

    Topics: Alkyl and Aryl Transferases; Animals; Cattle; Drug Design; Enzyme Inhibitors; Farnesyltranstransferase; Hydroxyquinolines; Indoles; Mice; NIH 3T3 Cells; Quinolones; Stereoisomerism

2005
Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity.
    Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11

    Topics: Alkyl and Aryl Transferases; Animals; Benzimidazoles; Enzyme Inhibitors; Farnesyltranstransferase; Indoles; Mice; NIH 3T3 Cells; Quinolones

2005
Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase.
    Bioorganic & medicinal chemistry letters, 2003, Apr-07, Volume: 13, Issue:7

    Topics: 3T3 Cells; Alkyl and Aryl Transferases; Animals; Biological Availability; Biphenyl Compounds; Crystallography, X-Ray; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; Half-Life; Imidazoles; Indicators and Reagents; Mice; Models, Molecular; Rats

2003
Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors.
    Journal of medicinal chemistry, 2004, Jan-29, Volume: 47, Issue:3

    Topics: Administration, Oral; Alkyl and Aryl Transferases; Animals; Benzamides; Biological Availability; Cell Membrane Permeability; Crystallography, X-Ray; Dogs; Drug Design; Farnesyltranstransferase; Imidazoles; Models, Molecular; Molecular Structure; Nitriles; Structure-Activity Relationship

2004
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.
    Bioorganic & medicinal chemistry letters, 2004, Nov-01, Volume: 14, Issue:21

    Topics: 4-Quinolones; Alkyl and Aryl Transferases; Crystallography, X-Ray; Farnesyltranstransferase; Models, Molecular; Pyridones; Quinolones; Structure-Activity Relationship

2004
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.
    Journal of medicinal chemistry, 2005, Jun-02, Volume: 48, Issue:11

    Topics: Alkyl and Aryl Transferases; Animals; Antimalarials; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Farnesyltranstransferase; Female; Humans; Malaria; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Plasmodium berghei; Plasmodium falciparum; Protein Prenylation; Quinolones; Rats; Structure-Activity Relationship

2005
Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.
    MedChemComm, 2013, Volume: 4, Issue:3

    Topics:

2013
Farnesyl transferase inhibitors: a major breakthrough in anticancer therapy? Naples, 12 April 2002.
    Anti-cancer drugs, 2002, Volume: 13, Issue:8

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; Humans; Piperidines; Pyridines; Quinolones

2002
Farnesyltransferase inhibitors in acute myeloid leukemia and myelodysplastic syndromes.
    Clinical lymphoma, 2003, Volume: 4 Suppl 1

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Benzodiazepines; Clinical Trials as Topic; Farnesyltranstransferase; Humans; Imidazoles; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Piperidines; Pyridines; Quinolones

2003
Farnesyltransferase inhibitors inhibit T-cell cytokine production at the posttranscriptional level.
    Blood, 2007, Sep-15, Volume: 110, Issue:6

    Topics: Antibodies, Monoclonal; Blotting, Western; CD28 Antigens; CD3 Complex; Cells, Cultured; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Farnesyltranstransferase; HSP40 Heat-Shock Proteins; Humans; Interferon-gamma; Interleukin-2; Interleukin-4; Lymphocyte Activation; MAP Kinase Kinase 4; Methionine; Phosphorylation; Piperidines; Protein Prenylation; Pyridines; Quinolones; Ribonuclease, Pancreatic; Ribosomal Protein S6 Kinases, 70-kDa; RNA Processing, Post-Transcriptional; T-Lymphocytes; Th1 Cells; Th2 Cells

2007
[Targeting KRAS pathway in NSCLC therapy].
    Bulletin du cancer, 2009, Volume: 96 Suppl

    Topics: Animals; Antineoplastic Agents; Benzenesulfonates; Carcinoma, Non-Small-Cell Lung; Farnesyltranstransferase; Genes, ras; Humans; Lung Neoplasms; Mice; Mitogen-Activated Protein Kinase Kinases; Mutation; Neoplasm Proteins; Niacinamide; Phenylurea Compounds; Piperidines; Pyridines; Quinolones; raf Kinases; ras Proteins; Sorafenib

2009
Ras homologue enriched in brain is a critical target of farnesyltransferase inhibitors in non-small cell lung cancer cells.
    Cancer letters, 2010, Nov-01, Volume: 297, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cisplatin; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Lung Neoplasms; Mechanistic Target of Rapamycin Complex 1; Monomeric GTP-Binding Proteins; Multiprotein Complexes; Mutation; Neuropeptides; Phosphorylation; Piperidines; Prenylation; Proteins; Pyridines; Quinolones; Ras Homolog Enriched in Brain Protein; Ribosomal Protein S6; RNA Interference; RNA, Messenger; Signal Transduction; TOR Serine-Threonine Kinases; Transcription Factors; Transfection

2010
The farnesyltransferase inhibitors tipifarnib and lonafarnib inhibit cytokines secretion in a cellular model of mevalonate kinase deficiency.
    Pediatric research, 2011, Volume: 70, Issue:1

    Topics: Acyclic Monoterpenes; Alendronate; Animals; Anti-Inflammatory Agents; Cell Line; Child; Child, Preschool; Cholesterol; Cytokines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Inflammation Mediators; Lovastatin; Male; Mevalonate Kinase Deficiency; Mice; Monocytes; Phosphotransferases (Alcohol Group Acceptor); Piperidines; Polyenes; Polyisoprenyl Phosphates; Polyunsaturated Alkamides; Pyridines; Quinolones; Terpenes

2011