Page last updated: 2024-09-04

lonafarnib and sirolimus

lonafarnib has been researched along with sirolimus in 5 studies

Compound Research Comparison

Studies (lonafarnib)	Trials (lonafarnib)	Recent Studies (post-2010) (lonafarnib)	Studies (sirolimus)	Trials (sirolimus)	Recent Studies (post-2010) (sirolimus)
224	34	90	20,711	2,368	11,516

Protein Interaction Comparison

Protein	Taxonomy	sirolimus (IC50)
Bile salt export pump	Homo sapiens (human)	10
ATP-dependent translocase ABCB1	Homo sapiens (human)	1.25
Cytochrome P450 3A4	Homo sapiens (human)	2
Cytochrome P450 2C9	Homo sapiens (human)	2
Peptidyl-prolyl cis-trans isomerase FKBP1A	Mus musculus (house mouse)	0.001
Cytochrome P450 2C19	Homo sapiens (human)	4
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	0.0897
Peptidyl-prolyl cis-trans isomerase FKBP1A	Homo sapiens (human)	0.0042
Regulatory-associated protein of mTOR	Homo sapiens (human)	0.225
Target of rapamycin complex subunit LST8	Homo sapiens (human)	0.225
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	1.9
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	1.1

Research

Studies (5)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (60.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	2 (40.00)	2.80

Authors

Authors	Studies
Laufer, S; Pillaiyar, T	1
Kurisu, K; Okamura, T	1
Bernhard, JC; Ferrière, JM; Ravaud, A; Robert, G; Wallerand, H	1
Lowe, SW; Mavrakis, KJ; Mills, JR; Pelletier, J; Silva, RL; Tam, W; Teruya-Feldstein, J; Wendel, HG; Zhu, H	1
Braddock, DT; Gordon, LB; Humphrey, JD; Kawamura, Y; Li, DS; Mikush, N; Murtada, SI; Ramachandra, AB; Ren, P; Tellides, G; Wang, M	1

Reviews

3 review(s) available for lonafarnib and sirolimus

Article	Year
Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy. Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2 Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Humans; Protein Kinase Inhibitors; SARS-CoV-2; Signal Transduction; Virus Replication	2022
[Molecular targeted therapy for malignant brain tumors]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 9 Topics: Antineoplastic Agents; Benzamides; Brain Neoplasms; Drug Delivery Systems; Drug Design; Drug Resistance, Neoplasm; Drug Therapy, Combination; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Glioma; Humans; Imatinib Mesylate; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Piperidines; Protein Kinases; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Quinazolines; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases	2005
[Targeted therapy for locally advanced and/or metastatic bladder cancer]. Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie, 2008, Volume: 18, Issue:7 Topics: Angiogenesis Inhibitors; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Disease Progression; Erlotinib Hydrochloride; Gefitinib; Genetic Therapy; Humans; Immunosuppressive Agents; Mutation; Piperidines; Protein Kinase Inhibitors; Pyridines; Quinazolines; Randomized Controlled Trials as Topic; Signal Transduction; Sirolimus; Targeted Gene Repair; Trastuzumab; Urinary Bladder Neoplasms	2008

Other Studies

2 other study(ies) available for lonafarnib and sirolimus

Article	Year
Tumorigenic activity and therapeutic inhibition of Rheb GTPase. Genes & development, 2008, Aug-15, Volume: 22, Issue:16 Topics: Animals; Antibiotics, Antineoplastic; Blotting, Western; Cell Transformation, Neoplastic; Cells, Cultured; Cellular Senescence; Doxorubicin; Eukaryotic Initiation Factor-4E; Farnesyltranstransferase; Female; Fibroblasts; Gene Dosage; Humans; Immunophenotyping; Immunosuppressive Agents; Lymphoma; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Mice, Knockout; Monomeric GTP-Binding Proteins; Multiprotein Complexes; Neuropeptides; Phosphorylation; Piperidines; Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; PTEN Phosphohydrolase; Pyridines; Ras Homolog Enriched in Brain Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transcription Factors; Tumor Suppressor Protein p53	2008
Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford progeria syndrome. eLife, 2023, 03-17, Volume: 12 Topics: Animals; Lamin Type A; Mice; Piperidines; Progeria; Pulse Wave Analysis; Sirolimus	2023

Article

Year

Tumorigenic activity and therapeutic inhibition of Rheb GTPase.

Genes & development, 2008, Aug-15, Volume: 22, Issue:16

Topics: Animals; Antibiotics, Antineoplastic; Blotting, Western; Cell Transformation, Neoplastic; Cells, Cultured; Cellular Senescence; Doxorubicin; Eukaryotic Initiation Factor-4E; Farnesyltranstransferase; Female; Fibroblasts; Gene Dosage; Humans; Immunophenotyping; Immunosuppressive Agents; Lymphoma; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Mice, Knockout; Monomeric GTP-Binding Proteins; Multiprotein Complexes; Neuropeptides; Phosphorylation; Piperidines; Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; PTEN Phosphohydrolase; Pyridines; Ras Homolog Enriched in Brain Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transcription Factors; Tumor Suppressor Protein p53

2008

Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford progeria syndrome.

eLife, 2023, 03-17, Volume: 12

Topics: Animals; Lamin Type A; Mice; Piperidines; Progeria; Pulse Wave Analysis; Sirolimus

2023