lonafarnib has been researched along with sch 44342 in 3 studies
| Studies (lonafarnib) | Trials (lonafarnib) | Recent Studies (post-2010) (lonafarnib) | Studies (sch 44342) | Trials (sch 44342) | Recent Studies (post-2010) (sch 44342) |
|---|---|---|---|---|---|
| 6 | 0 | 3 | 12 | 0 | 0 |
| 224 | 34 | 90 | 12 | 0 | 0 |
| Protein | Taxonomy | lonafarnib (IC50) | sch 44342 (IC50) |
|---|---|---|---|
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Homo sapiens (human) | 0.625 | |
| Protein farnesyltransferase subunit beta | Homo sapiens (human) | 0.625 | |
| Protein farnesyltransferase subunit beta | Rattus norvegicus (Norway rat) | 0.25 | |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Rattus norvegicus (Norway rat) | 0.25 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Afonso, A; Alvarez, CS; Bishop, WR; Connolly, M; Cooper, AB; del Rosario, J; Desai, J; Deskus, J; Ganguly, AK; Kelly, J; Kirschmeier, P; Liu, YT; Mallams, AK; Njoroge, FG; Patton, R; Pinto, P; Rane, DF; Remiszewski, S; Rossman, RR; Taveras, AG; Vibulbhan, B; Wang, J; Wang, L; Wolin, R; Wong, J | 1 |
| Albanese, MM; Alvarez, CS; Cesarz, D; del Rosario, J; Deskus, J; Doll, RJ; Ganguly, AK; Girijavallabhan, VM; Le, HV; Mallams, AK; Njoroge, FG; Piwinski, JJ; Remiszewski, S; Rossman, RR; Strickland, CL; Taveras, AG; Vibulbhan, B; Weber, PC; Windsor, WT; Wu, Z | 1 |
| Bell, IM | 1 |
1 review(s) available for lonafarnib and sch 44342
| Article | Year |
|---|---|
Inhibitors of farnesyltransferase: a rational approach to cancer chemotherapy?
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Drug Design; Farnesyltranstransferase; Genes, ras; Humans; Neoplasms | 2004 |
2 other study(ies) available for lonafarnib and sch 44342
| Article | Year |
|---|---|
(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl protein transferase inhibitor as a novel antitumor agent.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; COS Cells; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Macaca fascicularis; Mice; Mice, Nude; Piperidines; Protein Prenylation; Pyridines; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 1998 |
Tricyclic farnesyl protein transferase inhibitors: crystallographic and calorimetric studies of structure-activity relationships.
Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Binding Sites; Calorimetry; Crystallography, X-Ray; Cyclic N-Oxides; Enzyme Inhibitors; Heterocyclic Compounds, 3-Ring; Hydrogen Bonding; Models, Molecular; Piperidines; Protein Prenylation; Pyridines; Thermodynamics | 1999 |