Compounds > lonafarnib
Page last updated: 2024-09-04

lonafarnib and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one

lonafarnib has been researched along with 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one in 1 studies

Compound Research Comparison

Studies
(lonafarnib)		Trials
(lonafarnib)		Recent Studies (post-2010)
(lonafarnib)		Studies
(2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one)		Trials
(2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one)		Recent Studies (post-2010) (2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one)
22434904,82351,810

Protein Interaction Comparison

ProteinTaxonomylonafarnib (IC50)2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one (IC50)
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1Homo sapiens (human)4
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1Homo sapiens (human)4
Chain A, Methyltransferase WbddEscherichia coli68
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformHomo sapiens (human)1.6413
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit betaHomo sapiens (human)1.4218
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)1.002
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)9.614
Cytochrome P450 1A2Homo sapiens (human)1
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)1.6
Serine/threonine-protein kinase pim-1Homo sapiens (human)3.364
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)1.6
Casein kinase II subunit alpha'Homo sapiens (human)6.9
Phosphatidylinositol 3-kinase regulatory subunit alphaHomo sapiens (human)3.1638
5-hydroxytryptamine receptor 2AHomo sapiens (human)2.796
5-hydroxytryptamine receptor 2CHomo sapiens (human)1.002
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)2.3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformBos taurus (cattle)3.7533
Type-1 angiotensin II receptorOryctolagus cuniculus (rabbit)0.5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)1.4593
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Mus musculus (house mouse)0.5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformHomo sapiens (human)1.2922
Serine/threonine-protein kinase mTORHomo sapiens (human)4.1638
Serine/threonine-protein kinase mTORRattus norvegicus (Norway rat)2.5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)2.4845
Glycogen synthase kinase-3 betaHomo sapiens (human)8.1
Serine/threonine-protein kinase PLK1Homo sapiens (human)2.05
Casein kinase II subunit betaHomo sapiens (human)6.9
Casein kinase II subunit alphaHomo sapiens (human)6.9
DNA-dependent protein kinase catalytic subunitHomo sapiens (human)1.32
Mu-type opioid receptorCavia porcellus (domestic guinea pig)1.6
Serine/threonine-protein kinase pim-3Homo sapiens (human)1.4
Phosphoinositide 3-kinase regulatory subunit 5Homo sapiens (human)1.72
Serine/threonine-protein kinase PLK3Homo sapiens (human)3

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Allan, EK; Eaves, CJ; Elliott, MA; Godden, JL; Graham, SM; Holyoake, TL; Jørgensen, HG; Mountford, JC; Richmond, L1

Other Studies

1 other study(ies) available for lonafarnib and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one

ArticleYear
Lonafarnib reduces the resistance of primitive quiescent CML cells to imatinib mesylate in vitro.
    Leukemia, 2005, Volume: 19, Issue:7

    Topics: Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Benzoquinones; Cell Line, Tumor; Cell Proliferation; Chromones; Cytarabine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Imatinib Mesylate; Lactams, Macrocyclic; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Morpholines; Piperazines; Piperidines; Pyridines; Pyrimidines; Rifabutin

2005