lofexidine has been researched along with clonidine in 135 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 52 (38.52) | 18.7374 |
| 1990's | 16 (11.85) | 18.2507 |
| 2000's | 33 (24.44) | 29.6817 |
| 2010's | 31 (22.96) | 24.3611 |
| 2020's | 3 (2.22) | 2.80 |
| Authors | Studies |
|---|---|
| Albin, D; Bianchi, RG; Grebner, M; Gullikson, GW; Jones, PH; Moormann, AE; Pitzele, BS; Rubin, B; Sanguinetti, EL; Yu, SS | 1 |
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Batink, H; de Jonge, A; Thoolen, MJ; Timmermans, PB; van Zwieten, PA; Wilffert, B | 1 |
| de Jonge, A; Lam, E; Slothorst-Grisdijk, FP; Timmermans, PB; van Meel, JC; van Zwieten, PA | 1 |
| Benedetti, G; Del Bello, F; Diamanti, E; Giannella, M; Mammoli, V; Marchioro, C; Mattioli, L; Piergentili, A; Pigini, M; Quaglia, W; Titomanlio, F; Varrone, M | 1 |
| Agbaba, D; Azzali, E; Costantino, G; Glisic, S; Laurila, JM; Nikolic, K; Perovic, V; Pieroni, M; Radi, M; Scheinin, M; Srdic-Rajic, T; Tassini, S; Veljkovic, N; Vucicevic, J | 1 |
| Buccafusco, JJ; Li, W | 1 |
| Cammarata, P; Elko, E; Jin, Y; Verstappen, A; Yorio, T | 1 |
| Doyle, AE; Jarrott, B; Lewis, SJ | 1 |
| Cushman, P; Sowers, JR | 1 |
| Elko, EE; Jin, Y; Tran, T; Yorio, T | 1 |
| Katz, NL; Sanchez, J; Schlemmer, RF; Sobaski, N; Young, JE | 1 |
| Biedermann, J; Borbe, HO; León-Lomelí, A; Prop, G | 1 |
| Cook, CC; Lipsedge, MS; Scannell, TD | 1 |
| Ali, SF; Holson, RR; Newport, GD; Pizzi, WJ; Slikker, W | 1 |
| Batink, HD; de Jonge, A; Graf, E; Mathy, MJ; Prop, G; Thoolen, MJ; Timmermans, PB; van Zwieten, PA; Wilffert, B | 1 |
| Ali, SF; Holson, RR; Pizzi, WJ | 1 |
| Agren, H | 1 |
| Brunning, J; Keaney, FP; Mumford, JP | 1 |
| Lopez, LM; Mehta, JL | 2 |
| Jones, KP; Ravnikar, V; Schiff, I | 1 |
| Bonfiglio, JF; Fant, W; Ritschel, WA; Siegel, EG | 1 |
| Barry, DI; Clemmesen, L; Hemmingsen, R | 1 |
| Jarrott, B; Louis, WJ; Summers, RJ | 2 |
| Graf, E; Harms, YM; Prop, G; Timmermans, PB; van Kemenade, JE; van Zwieten, PA | 1 |
| Geyer, G; Resnick, RB; Washton, AM | 1 |
| Alexander, N; Maronde, RF; Velasquez, M; Vlachakis, ND | 1 |
| Dackis, CA; Gold, MS; Washton, AM | 1 |
| Resnick, RB; Washton, AM | 2 |
| Mehta, J; Mehta, P | 1 |
| Beitman, RE; Kuzma, RJ; McMahon, FG; Morledge, J; Mroczek, W; Rolf, CN; Tsai, TH | 1 |
| Garwood, J; Perzel, JF; Resnick, RB; Washton, AM | 1 |
| Annitto, WJ; Extein, I; Gold, MS; Pottash, AC; Sweeney, DR | 2 |
| Chang, H; Ewert, SM; Nagel, RL | 1 |
| Chasseaud, LF; Fowkes, AG; Girkin, R; Hawkins, DR; Kesselring, K; Midgley, I | 1 |
| Betzing, H; Biedermann, J | 1 |
| Genthe, H; Wagener, HH | 1 |
| Graf, E | 1 |
| Graf, E; Sieck, A; Wenzl, H; Winkelmann, J | 1 |
| Doppelfeld, IS; Graf, E; Prop, G | 1 |
| Beitman, RE; Fontaine, R; Friehe, H; Gibson, JP; Larson, EJ; Tsai, TH | 1 |
| Beitman, RE; Gibson, JP; Larson, EJ; Tsai, TH | 1 |
| Fontaine, R; Friehe, H; Gibson, JP; Larson, EJ; Sells, DM | 1 |
| Chasseaud, LF; Darragh, A; Midgley, I; Taylor, T | 1 |
| Aigner, A; Schmidt, U | 1 |
| Dollery, CT; Reid, JL | 1 |
| Garrett, BN; Kaplan, NM | 1 |
| Dustan, HP; Oparil, S; Smith, LR; Wilkins, LH; Winternitz, SR | 1 |
| Bloomfield, SS; Conradi, EC; Corns-Hurwitz, RH; Cowart, TD; Degenhart, WJ; Fagan, TC; Gaffney, TE; Grossman, WJ; Harmon, GE; Hsu, CY; Lipicky, RJ; Sinkfield, AW | 1 |
| Lal, H; Shearman, GT; Ursillo, RC | 2 |
| Bravo, EL; Fouad, FM; Tarazi, RC; Vidt, DG; Williams, H | 1 |
| Corrigan, FM; MacDonald, S; Reynolds, GP | 1 |
| Stewart, AM; Wylie, AS | 1 |
| Alcorn, R; Cox, S | 1 |
| Greenwood, J; Seivewright, NA | 1 |
| Bearn, J; Gossop, M; Strang, J | 3 |
| Beckford, H; Kahn, A; Mumford, JP; Rogers, GA | 1 |
| Hu, WH; Lin, SK; Strang, J; Su, LW; Tsai, CJ | 1 |
| Brown, AS; Fleming, PM | 1 |
| Carnwath, T; Hardman, J | 1 |
| Akhurst, JS | 1 |
| Gerada, C; Kemp, K; Smith, P | 1 |
| Erb, S; Hitchcott, PK; Mueller, D; Rajabi, H; Shaham, Y; Stewart, J | 1 |
| Bearn, J; Buntwal, N; Gossop, M; Strang, J | 1 |
| Anderson, D; Bradbury, L; Stones, RW | 1 |
| Delsignore, R; Di Gennaro, C; Gardini, S; Gerra, G; Giusti, F; Zaimovic, A; Zambelli, U | 1 |
| Grimm, JW; Highfield, D; Shaham, Y; Shalev, U; Yap, J | 1 |
| Niederhofer, H | 1 |
| Alcorn, R; Feinmann, C; White, R | 1 |
| Ali, RL; Farrell, M; Gowing, LR; White, JM | 1 |
| Allen, S; Farrell, M; Gupta, J; Howells, C; Marsden, J; Stillwell, G | 1 |
| Mair, A; Niederhofer, H; Staffen, W | 2 |
| Bigelow, GE; Strain, EC; Walsh, SL | 1 |
| Bearn, J; Best, D; Beswick, T; Gossop, M; Rees, S; Strang, J | 1 |
| Fu, L; Huang, DB; Yu, ZF | 1 |
| Epstein, DH; Preston, KL; Schmittner, J; Schroeder, JR | 1 |
| Funk, D; Harding, S; Juzytsch, W; Lê, AD; Shaham, Y | 1 |
| Bearn, J; de Wet, CJ; Glasper, A; Gossop, M; Reed, LJ | 1 |
| Banbery, J; Brearley, R; Finnegan, O; Raistrick, D; Thistlethwaite, G; West, D | 1 |
| Ali, R; Gowing, L; White, J | 1 |
| Cubells, JF; Tang, YL; Zhao, C; Zhao, D | 1 |
| Bearn, J; Best, D; Beswick, T; Gossop, M; McCambridge, J; Rees, S; Strang, J | 1 |
| Doebrick, C; Kimmerling, A; Kosten, TR; Sinha, R | 1 |
| Bleiberg, J; Epstein, DH; Krantz, MJ; Preston, KL; Schmittner, J; Schroeder, JR | 1 |
| Comer, SD; Foltin, RW; Haney, M; Hart, CL; Reed, SC; Vosburg, SK | 1 |
| Al-Ghananeem, AM | 1 |
| Gao, L; Hu, M; Kang, L; Li, B; Li, J; Li, S; Wang, D | 1 |
| Akerele, E; Boardman, K; Collins, J; Davies, DK; Elkashef, A; Fischman, MW; Herman, BH; Kleber, H; Ling, W; McSherry, F; Miotto, K; Montgomery, A; Montoya, I; O'Brien, CP; Walsh, R; Yu, E | 1 |
| Akerele, E; Al-Ghananeem, AM; Elkashef, A; Fischman, MW; Herman, BH; Kleber, H; Ling, W; Miotto, K; O'Brien, CP; Yu, E | 1 |
| Chen, HX; Hao, W; Li, J; Li, SX; Liu, TT; Lu, L; Shen, LY; Shi, J; Wang, X; Xu, GZ | 1 |
| Eid, NC; Epstein, DH; Krantz, MJ; Preston, KL; Schmittner, J; Schroeder, JR | 1 |
| Ali, R; Gowing, L; White, JM | 2 |
| Abbassi, M; Al Ghananeem, AM; Herman, BH; Ling, W; Miotto, K; Montgomery, A; O'Brien, CP; Walsh, R; Yu, E | 1 |
| Hu, M; Huang, M; Kang, L; Li, J; Wang, X | 1 |
| Gish, EC; Honey, BL; Johnson, PN; Miller, JL | 1 |
| Meader, N | 1 |
| Bramness, J; Gossop, M; Lobmaier, P; Waal, H | 1 |
| Day, E; Strang, J | 1 |
| Law, F; Melichar, J; O'Shea, J; Praveen, KT | 1 |
| Fivel, PA; Kohut, SJ; Mello, NK | 1 |
| Anderson, A; Chen, CY; De La Garza, R; Dib, E; Galloway, GP; Haile, CN; Hawkins, RY; Kahn, R; Lao, G; Mahoney, JJ; Mendelson, J; Mojsiak, J; Newton, TF | 1 |
| Cheong, YC; Smotra, G; Williams, AC | 1 |
| Acheson, AG; Dashwood, MR; Eames, T; Gruss, H; Henry, Y; Rayment, SJ; Scholefield, JH; Simpson, JA; Wilson, VG | 1 |
| Vartak, AP | 1 |
| Bisaga, A; Brooks, D; Carpenter, KM; Choi, JC; Dakwar, E; Glass, A; Levin, FR; Mahony, A; Mariani, JJ; Nunes, EV; Pavlicova, M; Sullivan, MA | 1 |
| Clinch, T; Gorodetzky, CW; Gullo, K; Mannix, S; Reinders, S; Vernon, MK | 1 |
| Ali, R; Farrell, M; Gowing, L; White, JM | 1 |
| Ali, R; Gowing, L; Mbewe, D; White, JM | 1 |
| Biswas, K; Gorodetzky, CW; Gullo, KL; Martin, PR; Saxon, AJ; Walsh, SL | 1 |
| Coulton, S; Diaper, AM; Law, FD; Melichar, JK; Myles, JS; Nutt, DJ | 1 |
| Brezing, CA; Brooks, D; Choi, CJ; Levin, FR; Mahony, AL; Mariani, JJ; Pavlicova, M | 1 |
| Assam, PN; Chan, E; Cheok, C; de Souza, NN; Guo, S; Kandasami, G; Koh, PK; Lee, KM; Manning, V; Pangjaya, J; Sultana, R; Wijesinghe, R; Wong, KE; Yang, Y | 1 |
| Traynor, K | 1 |
| Byland, E; Canupp, K; Dunlap, J; Mospan, C; Mospan, G; Whitaker, WB; Xiong, L | 1 |
| Brooks, T; Doughty, B; Morgenson, D | 1 |
| Bryce, C | 1 |
| Hussar, DA | 1 |
| Fogelman, N; Hermes, G; Hyman, SM; Kosten, TR; Sinha, R | 1 |
| Darpö, B; Ferber, G; Longstreth, J; Pirner, M | 1 |
| Berger, AA; Hasoon, J; Jung, JW; Kassem, H; Kaye, AD; Mousa, M; Patel, A; Urits, I; Virgen, CG; Viswanath, O; Zusman, R | 1 |
| Caliendo, T; Hilas, O | 1 |
| Baker, N; Brady, K; Cortese, B; Guille, C; King, C; McRae-Clark, A; Nunn, L; Ramakrishnan, V; Rogers, T | 1 |
20 review(s) available for lofexidine and clonidine
| Article | Year |
|---|---|
Clonidine treatment of the opiate withdrawal syndrome. A review of clinical trials of a theory.
Topics: Adrenergic Fibers; Animals; Antidepressive Agents, Tricyclic; Brain; Clinical Trials as Topic; Clonidine; Dextropropoxyphene; Drug Therapy, Combination; Heroin Dependence; Humans; Locus Coeruleus; Methadone; Morphine; Naltrexone; Narcotics; Norepinephrine; Rats; Substance Withdrawal Syndrome | 1986 |
The sequential use of clonidine and naltrexone in the treatment of opiate addicts.
Topics: Adult; Baclofen; Clonidine; Drug Therapy, Combination; Electric Stimulation Therapy; Endorphins; Ethanol; Female; Humans; Locus Coeruleus; Male; Methyldopa; Naloxone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1984 |
Lofexidine and opioid withdrawal.
Topics: Antihypertensive Agents; Clonidine; Humans; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1995 |
What is important in drug misuse treatment?
Topics: Buprenorphine; Clonidine; Humans; Methadone; Naltrexone; Narcotic Antagonists; Substance Withdrawal Syndrome; Substance-Related Disorders; United Kingdom | 1996 |
An addict who wants to detoxify.
Topics: Acquired Immunodeficiency Syndrome; Adult; Clonidine; Heroin Dependence; Humans; Jaundice; Male; Naltrexone; Needle Sharing; Serologic Tests | 1998 |
Lofexidine for opiate detoxification: review of recent randomised and open controlled trials.
Topics: Clonidine; Humans; Methadone; Narcotic Antagonists; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Treatment Outcome | 1999 |
Alpha2-adrenergic agonists in opioid withdrawal.
Topics: Adrenergic alpha-Agonists; Clonidine; Confidence Intervals; Controlled Clinical Trials as Topic; Humans; Methadone; Narcotics; Odds Ratio; Opioid-Related Disorders; Substance Withdrawal Syndrome; Treatment Outcome | 2002 |
Opioid antagonists with minimal sedation for opioid withdrawal.
Topics: Adrenergic alpha-Agonists; Clinical Trials as Topic; Clonidine; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Randomized Controlled Trials as Topic | 2006 |
Opiate addiction in China: current situation and treatments.
Topics: Buprenorphine; China; Clonidine; Drugs, Chinese Herbal; HIV Infections; Humans; Methadone; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Substance Abuse, Intravenous; Substance Withdrawal Syndrome; Sympatholytics | 2006 |
Buprenorphine for the management of opioid withdrawal.
Topics: Acute Disease; Buprenorphine; Clonidine; Humans; Narcotic Antagonists; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome | 2009 |
Lofexidine, an {alpha}2-receptor agonist for opioid detoxification.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Clinical Trials as Topic; Clonidine; Humans; Narcotic Antagonists; Opioid-Related Disorders; Substance Withdrawal Syndrome | 2010 |
A comparison of methadone, buprenorphine and alpha(2) adrenergic agonists for opioid detoxification: a mixed treatment comparison meta-analysis.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Buprenorphine; Clonidine; Data Interpretation, Statistical; Humans; Methadone; Narcotic Antagonists; Narcotics; Odds Ratio; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Treatment Outcome | 2010 |
The pharmacological treatment of opioid addiction--a clinical perspective.
Topics: Adrenergic Agonists; Analgesics, Opioid; Buprenorphine; Clonidine; Drug Therapy, Combination; Humans; Inactivation, Metabolic; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Social Support; Substance Withdrawal Syndrome | 2010 |
Non-surgical interventions for the management of chronic pelvic pain.
Topics: Amines; Amitriptyline; Analgesics; Chronic Pain; Clonidine; Contraceptive Agents, Female; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Goserelin; Humans; Medroxyprogesterone Acetate; Pain Measurement; Pelvic Pain; Psychotherapy; Randomized Controlled Trials as Topic | 2014 |
Alpha₂-adrenergic agonists for the management of opioid withdrawal.
Topics: Acute Disease; Adrenergic alpha-2 Receptor Agonists; Clonidine; Controlled Clinical Trials as Topic; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome | 2016 |
Buprenorphine for managing opioid withdrawal.
Topics: Acute Disease; Buprenorphine; Clonidine; Female; Humans; Male; Methadone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome | 2017 |
Opioid antagonists with minimal sedation for opioid withdrawal.
Topics: Adrenergic alpha-Agonists; Clonidine; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Non-Randomized Controlled Trials as Topic; Opioid-Related Disorders; Prospective Studies; Randomized Controlled Trials as Topic; Severity of Illness Index; Substance Withdrawal Syndrome | 2017 |
Lofexidine: A Newly FDA-Approved, Nonopioid Treatment for Opioid Withdrawal.
Topics: Adult; Clonidine; Humans; Narcotic Antagonists; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome; United States; United States Food and Drug Administration | 2019 |
A Comprehensive Update of Lofexidine for the Management of Opioid Withdrawal Symptoms.
Topics: Analgesics, Opioid; Clonidine; Humans; Opioid-Related Disorders; Substance Withdrawal Syndrome | 2020 |
Lofexidine: A Novel Treatment Option for Opioid Withdrawal Symptoms.
Topics: Analgesics, Opioid; Clonidine; Humans; Opioid-Related Disorders; United States | 2020 |
46 trial(s) available for lofexidine and clonidine
| Article | Year |
|---|---|
Alcohol withdrawal syndrome: clinical and hormonal responses to alpha 2-adrenergic agonist treatment.
Topics: Adrenergic alpha-Agonists; Adult; Alcoholism; Catecholamines; Clinical Trials as Topic; Clonidine; Double-Blind Method; Ethanol; Humans; Male; Middle Aged; Prolactin; Substance Withdrawal Syndrome | 1989 |
Another trial that failed.
Topics: Attitude of Health Personnel; Clinical Trials as Topic; Clonidine; Double-Blind Method; Humans; Opioid-Related Disorders; Random Allocation; Research Support as Topic; Substance Withdrawal Syndrome | 1988 |
Clonidine treatment of the opiate withdrawal syndrome. A review of clinical trials of a theory.
Topics: Adrenergic Fibers; Animals; Antidepressive Agents, Tricyclic; Brain; Clinical Trials as Topic; Clonidine; Dextropropoxyphene; Drug Therapy, Combination; Heroin Dependence; Humans; Locus Coeruleus; Methadone; Morphine; Naltrexone; Narcotics; Norepinephrine; Rats; Substance Withdrawal Syndrome | 1986 |
Long-term experience with lofexidine in the treatment of mild-to-moderate essential hypertension.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Random Allocation; Time Factors | 1985 |
Opiate withdrawal using lofexidine, a clonidine analogue with fewer side effects.
Topics: Adult; Ambulatory Care; Antihypertensive Agents; Clinical Trials as Topic; Clonidine; Humans; Male; Methadone; Methadyl Acetate; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1983 |
Hemodynamic effect of lofexidine with a diuretic in hypertension.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Clonidine; Drug Therapy, Combination; Epinephrine; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Isometric Contraction; Male; Middle Aged; Norepinephrine | 1983 |
Comparative efficacy and safety of lofexidine and clonidine given alone or concomitantly with hydrochlorothiazide in hypertensive outpatients.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged | 1982 |
Lofexidine, a new, antihypertensive imidazoline derivative. Clinical profile of action with single-drug treatment and in combination with hydrochlorothiazide.
Topics: Antihypertensive Agents; Blood Chemical Analysis; Blood Pressure; Clonidine; Drug Combinations; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged | 1982 |
Double-blind comparison of the hypotensive, sedative and salivary flow effects of lofexidine and clonidine in normal subjects.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clonidine; Double-Blind Method; Electrocardiography; Heart Rate; Humans; Hypnotics and Sedatives; Male; Salivation | 1982 |
Lofexidine and clonidine in moderate essential hypertension.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Posture; Random Allocation | 1981 |
Antihypertensive effects of lofexidine in patients with essential hypertension.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; Catecholamines; Clonidine; Dose-Response Relationship, Drug; Heart Rate; Humans; Hypertension; Middle Aged; Natriuresis; Potassium | 1982 |
Randomised double-blind comparison of lofexidine and methadone in the in-patient treatment of opiate withdrawal.
Topics: Adolescent; Adult; Blood Pressure; Clonidine; Double-Blind Method; Female; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Narcotic Antagonists; Neurologic Examination; Substance Abuse Detection; Substance Withdrawal Syndrome | 1996 |
Double-blind study of lofexidine and clonidine in the detoxification of opiate addicts in hospital.
Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Narcotic Antagonists; Neurologic Examination; Opioid-Related Disorders; Patient Admission; Substance Withdrawal Syndrome | 1997 |
Double-blind randomised controlled trial of lofexidine versus clonidine in the treatment of heroin withdrawal.
Topics: Adult; Circadian Rhythm; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heroin; Humans; Hypotension, Orthostatic; Male; Narcotic Antagonists; Severity of Illness Index; Substance Withdrawal Syndrome | 1997 |
Accelerated lofexidine treatment regimen compared with conventional lofexidine and methadone treatment for in-patient opiate detoxification.
Topics: Adult; Analysis of Variance; Chi-Square Distribution; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hypotension; Male; Methadone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Severity of Illness Index; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors; Treatment Outcome | 1998 |
Randomised double-blind comparison of lofexidine and clonidine in the out-patient treatment of opiate withdrawal.
Topics: Adrenergic alpha-Agonists; Adult; Ambulatory Care; Blood Pressure; Chi-Square Distribution; Clonidine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methadone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Severity of Illness Index; Substance Withdrawal Syndrome; Time Factors; Treatment Outcome | 1998 |
Naltrexone and lofexidine combination treatment compared with conventional lofexidine treatment for in-patient opiate detoxification.
Topics: Adult; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Heroin Dependence; Humans; Male; Methadone; Naltrexone; Narcotic Antagonists; Neurologic Examination; Opioid-Related Disorders; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome | 2000 |
Randomized placebo controlled trial of lofexidine hydrochloride for chronic pelvic pain in women.
Topics: Acetaminophen; Adrenergic alpha-Agonists; Anti-Inflammatory Agents, Non-Steroidal; Body Mass Index; Chronic Disease; Clonidine; Codeine; Drug Therapy, Combination; Female; Humans; Pelvic Pain; Placebos; Treatment Outcome | 2001 |
Lofexidine versus clonidine in rapid opiate detoxification.
Topics: Adult; Analysis of Variance; Clonidine; Double-Blind Method; Humans; Inactivation, Metabolic; Male; Naloxone; Opioid-Related Disorders; Opium; Substance Withdrawal Syndrome; Time Factors | 2001 |
Prison based detoxification for opioid dependence: a randomised double blind controlled trial of lofexidine and methadone.
Topics: Adult; Analysis of Variance; Chi-Square Distribution; Clonidine; Double-Blind Method; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; Prisons; Substance Withdrawal Syndrome | 2002 |
Lofexidine in hyperactive and impulsive children with autistic disorder.
Topics: Autistic Disorder; Child; Child, Preschool; Clonidine; Double-Blind Method; Female; Humans; Hyperkinesis; Impulsive Behavior; Male; Personality Assessment | 2002 |
Evaluation of the effects of lofexidine and clonidine on naloxone-precipitated withdrawal in opioid-dependent humans.
Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Naloxone; Narcotic Antagonists; Narcotics; Substance Withdrawal Syndrome | 2003 |
A placebo-controlled study of lofexidine in the treatment of children with tic disorders and attention deficit hyperactivity disorder.
Topics: Adolescent; Adrenergic Agonists; Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Blood Pressure; Child; Clonidine; Double-Blind Method; Female; Humans; Interviews as Topic; Male; Neuropsychological Tests; Tic Disorders; Treatment Outcome | 2003 |
[Clinical observation on effect of modified banxia houpu decoction in treating patients with protracted heroin abstinence syndrome].
Topics: Adolescent; Adult; Clonidine; Drugs, Chinese Herbal; Female; Heroin Dependence; Humans; Male; Narcotic Antagonists; Phytotherapy; Substance Withdrawal Syndrome | 2004 |
A comparison of buprenorphine and lofexidine for community opiate detoxification: results from a randomized controlled trial.
Topics: Adolescent; Adult; Buprenorphine; Clonidine; Community Mental Health Services; Female; Humans; Male; Middle Aged; Narcotic Antagonists; Opioid-Related Disorders; Treatment Outcome | 2005 |
In-patient detoxification procedures, treatment retention, and post-treatment opiate use: comparison of lofexidine + naloxone, lofexidine + placebo, and methadone.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Clonidine; Cohort Studies; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Length of Stay; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Recurrence; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Treatment Outcome | 2007 |
Effects of lofexidine on stress-induced and cue-induced opioid craving and opioid abstinence rates: preliminary findings.
Topics: Adult; Behavior, Addictive; Clonidine; Cues; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Secondary Prevention; Stress, Psychological; Substance Withdrawal Syndrome; Time Factors; Treatment Outcome | 2007 |
Hemodynamic and cognitive effects of lofexidine and methadone coadministration: a pilot study.
Topics: Adolescent; Adult; Blood Pressure; Clonidine; Cognition; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Humans; Male; Methadone; Middle Aged; Narcotic Antagonists; Narcotics; Pilot Projects; Prospective Studies; Substance Withdrawal Syndrome | 2007 |
Effects of THC and lofexidine in a human laboratory model of marijuana withdrawal and relapse.
Topics: Adrenergic alpha-Agonists; Adult; Affect; Appetite; Attention; Cannabinoids; Clonidine; Double-Blind Method; Dronabinol; Drug Therapy, Combination; Humans; Male; Marijuana Abuse; Mental Recall; Psychomotor Performance; Psychotropic Drugs; Secondary Prevention; Sleep; Substance Withdrawal Syndrome | 2008 |
Pharmacokinetics of lofexidine hydrochloride in healthy volunteers.
Topics: Adult; Clonidine; Cross-Over Studies; Humans; Male; Pilot Projects; Tandem Mass Spectrometry; Young Adult | 2009 |
Tai-Kang-Ning, a Chinese herbal medicine formula, alleviates acute heroin withdrawal.
Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Double-Blind Method; Drugs, Chinese Herbal; Female; Heroin Dependence; Humans; Male; Narcotic Antagonists; Severity of Illness Index; Substance Withdrawal Syndrome | 2008 |
A Phase 3 placebo-controlled, double-blind, multi-site trial of the alpha-2-adrenergic agonist, lofexidine, for opioid withdrawal.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Clonidine; Data Collection; Double-Blind Method; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Substance Abuse Detection; Substance Withdrawal Syndrome; Survival Analysis; Treatment Outcome | 2008 |
Clinical pharmacokinetics of lofexidine, the alpha 2-adrenergic receptor agonist, in opiate addicts plasma using a highly sensitive liquid chromatography tandem mass spectrometric analysis.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Biological Availability; Chromatography, Liquid; Clonidine; Double-Blind Method; Humans; Opioid-Related Disorders; Tandem Mass Spectrometry; Young Adult | 2008 |
A comparative clinical study of the effects of the traditional Chinese medicine Jinniu capsules and lofexidine on acute heroin withdrawal symptoms.
Topics: Adult; Clonidine; Double-Blind Method; Drugs, Chinese Herbal; Female; Heroin Dependence; Humans; Male; Narcotic Antagonists; Severity of Illness Index; Substance Withdrawal Syndrome; Time Factors; Treatment Outcome; Young Adult | 2008 |
Electrocardiographic effects of lofexidine and methadone coadministration: secondary findings from a safety study.
Topics: Adult; Clonidine; Drug Administration Schedule; Drug Therapy, Combination; Electrocardiography; Female; Humans; Male; Methadone; Narcotic Antagonists; Opioid-Related Disorders; Pilot Projects; Risk Factors; Sex Characteristics | 2009 |
A study on Fu-Yuan Pellet, a traditional chinese medicine formula for detoxification of heroin addictions.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Clonidine; Drugs, Chinese Herbal; Female; Heroin Dependence; Humans; Male; Medicine, Chinese Traditional; Middle Aged; Narcotic Antagonists; Substance Withdrawal Syndrome; Treatment Outcome | 2009 |
Outpatient versus inpatient opioid detoxification: a randomized controlled trial.
Topics: Analgesics, Opioid; Clonidine; Female; Heroin; Heroin Dependence; Humans; Inpatients; Male; Methadone; Narcotics; Opioid-Related Disorders; Outcome Assessment, Health Care; Outpatients; Substance Withdrawal Syndrome; Substance-Related Disorders; Treatment Outcome | 2011 |
Assessment of safety, cardiovascular and subjective effects after intravenous cocaine and lofexidine.
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adult; Behavior, Addictive; Blood Pressure; Clonidine; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Double-Blind Method; Drug Administration Schedule; Drug Interactions; Drug Users; Female; Heart Rate; Humans; Infusions, Intravenous; Male; Middle Aged; Young Adult | 2014 |
Dronabinol and lofexidine for cannabis use disorder: A randomized, double-blind, placebo-controlled trial.
Topics: Adolescent; Adult; Cannabinoid Receptor Agonists; Clonidine; Craving; Double-Blind Method; Dronabinol; Female; Humans; Male; Marijuana Abuse; Medication Adherence; Middle Aged; Narcotic Antagonists; Secondary Prevention; Substance Withdrawal Syndrome | 2016 |
A phase III, randomized, multi-center, double blind, placebo controlled study of safety and efficacy of lofexidine for relief of symptoms in individuals undergoing inpatient opioid withdrawal.
Topics: Adult; Analgesics, Opioid; Animals; Clonidine; Double-Blind Method; Female; Humans; Inpatients; Male; Middle Aged; Narcotic Antagonists; Opioid-Related Disorders; Substance Withdrawal Syndrome; United Kingdom | 2017 |
Buprenorphine/naloxone versus methadone and lofexidine in community stabilisation and detoxification: A randomised controlled trial of low dose short-term opiate-dependent individuals.
Topics: Analgesics, Opioid; Buprenorphine, Naloxone Drug Combination; Clonidine; Craving; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methadone; Narcotic Antagonists; Opioid-Related Disorders; Substance Withdrawal Syndrome; Treatment Outcome; Young Adult | 2017 |
Abstinence and reduced frequency of use are associated with improvements in quality of life among treatment-seekers with cannabis use disorder.
Topics: Adult; Clonidine; Double-Blind Method; Dronabinol; Female; Humans; Male; Marijuana Abuse; Marijuana Smoking; Middle Aged; Motivation; Narcotic Antagonists; Quality of Life; Sex Factors; Smoking Reduction; Surveys and Questionnaires; Temperance; Treatment Outcome | 2018 |
Lofexidine versus diazepam for the treatment of opioid withdrawal syndrome: A double-blind randomized clinical trial in Singapore.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Clonidine; Craving; Diazepam; Double-Blind Method; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Opioid-Related Disorders; Pupil; Singapore; Substance Withdrawal Syndrome | 2018 |
Lofexidine in Combination With Oral Naltrexone for Opioid Use Disorder Relapse Prevention: A Pilot Randomized, Double-Blind, Placebo-Controlled Study.
Topics: Administration, Oral; Adolescent; Adult; Chemoprevention; Clonidine; Craving; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Intention to Treat Analysis; Male; Medication Adherence; Middle Aged; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Patient Compliance; Pilot Projects; Recurrence; Secondary Prevention; Substance Withdrawal Syndrome; Treatment Outcome; Young Adult | 2019 |
Effect of lofexidine on cardiac repolarization during treatment of opioid withdrawal.
Topics: Adolescent; Adult; Analgesics, Opioid; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Heart; Heart Conduction System; Heart Rate; Humans; Male; Middle Aged; Narcotic Antagonists; Substance Withdrawal Syndrome; Young Adult | 2019 |
The impact of lofexidine on stress-related opioid craving and relapse: Design and methodology of a randomized clinical trial.
Topics: Analgesics, Opioid; Clonidine; COVID-19; Craving; Humans; Hypothalamo-Hypophyseal System; Pandemics; Pituitary-Adrenal System; Recurrence; SARS-CoV-2 | 2021 |
70 other study(ies) available for lofexidine and clonidine
| Article | Year |
|---|---|
Potential antisecretory antidiarrheals. 2. Alpha 2-adrenergic 2-[(aryloxy)alkyl]imidazolines.
Topics: Adrenergic alpha-Agonists; Animals; Antidiarrheals; Blood Pressure; Blood-Brain Barrier; Chemical Phenomena; Chemistry; Cholera Toxin; Dogs; Gastrointestinal Motility; Imidazoles; In Vitro Techniques; Intestinal Absorption; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha; Structure-Activity Relationship; Thermodynamics | 1990 |
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Blood Pressure; Brain; Cell Membrane; Clonidine; Kinetics; Prazosin; Quinazolines; Rats; Receptors, Adrenergic, alpha; Structure-Activity Relationship; Vasoconstriction | 1984 |
Characterization of alpha-adrenoceptor populations. Quantitative relationships between cardiovascular effects initiated at central and peripheral alpha-adrenoceptors.
Topics: Animals; Blood Pressure; Blood Vessels; Brain; Hemodynamics; Male; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha | 1981 |
Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect.
Topics: | 2012 |
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin.
Topics: Adrenergic alpha-Agonists; Antibiotics, Antineoplastic; Apoptosis; Doxorubicin; Drug Synergism; Humans; K562 Cells; Ligands; Molecular Structure; Oxazoles; Receptors, Adrenergic, alpha-2; Rilmenidine | 2016 |
Effectiveness of alpha 2-adrenergic receptor stimulation in reducing the central toxicity following cholinesterase inhibition.
Topics: Adrenergic alpha-Agonists; Animals; Behavior, Animal; Cholinesterase Inhibitors; Clonidine; Diazepam; Dose-Response Relationship, Drug; Guanabenz; Guanfacine; Lethal Dose 50; Male; Motor Activity; Pyridostigmine Bromide; Rats; Rats, Inbred Strains; Soman | 1992 |
Effects of lofexidine, an alpha 2-adrenoreceptor agonist, on ocular blood flow and ion transport of rabbit iris-ciliary body.
Topics: Adrenergic alpha-Agonists; Animals; Biological Transport; Ciliary Body; Clonidine; Female; Hemodynamics; Intraocular Pressure; Iris; Male; Microspheres; Pupil; Rabbits; Regional Blood Flow; Uvea | 1992 |
Rapid eye movement sleep and the associated cardiovascular changes during and after continuous 10-day infusion of clonidine in normotensive rats: comparison with lofexidine and S3341.
Topics: Animals; Blood Pressure; Cardiovascular System; Clonidine; Drug Administration Schedule; Female; Heart Rate; Infusions, Intravenous; Oxazoles; Rats; Rats, Inbred Strains; Rilmenidine; Sleep, REM; Time Factors | 1987 |
Inhibition of adenylate cyclase in bovine ciliary process and rabbit iris ciliary body to alpha 2-adrenergic agonists.
Topics: Adenine; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adrenergic alpha-Agonists; Animals; Cattle; Cell Fractionation; Ciliary Body; Clonidine; Iris; Isoproterenol; Membranes; Pertussis Toxin; Rabbits; Sodium Chloride; Virulence Factors, Bordetella | 1989 |
Differential effects of clonidine analogs on food intake in rabbits and monkeys.
Topics: Animals; Clonidine; Dose-Response Relationship, Drug; Eating; Feeding Behavior; Female; Macaca; Male; Rabbits; Sodium Chloride | 1989 |
Two stereoisomeric imidazoline derivatives: synthesis and optical and alpha 2-adrenoceptor activities.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Brain; Clonidine; Drug Evaluation, Preclinical; Imidazoles; Indicators and Reagents; Male; Optical Rotation; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stereoisomerism; Structure-Activity Relationship | 1986 |
Neurochemical evaluation of rats prenatally exposed to the adrenergic agonists clonidine and lofexidine.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Body Weight; Brain; Brain Chemistry; Clonidine; Drug Evaluation, Preclinical; Female; Membrane Proteins; Neurotransmitter Agents; Ornithine Decarboxylase; Pregnancy; Prenatal Exposure Delayed Effects; Rats | 1988 |
Interference of enantiomers of lofexidine with alpha-adrenoceptors.
Topics: Animals; Binding, Competitive; Blood Pressure; Clonidine; Electric Stimulation; Heart Rate; Hemodynamics; Male; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stereoisomerism | 1985 |
Behavioral evaluation of rats prenatally exposed to the adrenergic agonists clonidine and lofexidine.
Topics: Animals; Antihypertensive Agents; Behavior, Animal; Body Weight; Clonidine; Drug Evaluation, Preclinical; Female; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Reflex, Startle; Swimming | 1988 |
Lofexidine in alcohol withdrawal states.
Topics: Attention; Blood Pressure; Clonidine; Ethanol; Female; Humans; Male; Substance Withdrawal Syndrome | 1986 |
A preliminary evaluation of the effect of lofexidine on vasomotor flushes in post-menopausal women.
Topics: Clonidine; Drug Evaluation; Female; Flushing; Humans; Menopause; Middle Aged; Vasomotor System | 1985 |
Investigation of clonidine and lofexidine for the treatment of barbiturate withdrawal in mice.
Topics: Animals; Barbiturates; Clonidine; Male; Mice; Mice, Inbred DBA; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1985 |
Blind study of the effect of the alpha-adrenergic agonists clonidine and lofexidine on alcohol withdrawal in the rat.
Topics: Alcohol Drinking; Alcohol Withdrawal Delirium; Animals; Behavior, Animal; Clonidine; Humans; Male; Psychoses, Alcoholic; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1984 |
Lofexidine, a clonidine analogue effective in opiate withdrawal.
Topics: Clonidine; Humans; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1981 |
Characterization of central alpha-adrenoceptors using 3H-clonidine and its derivatives.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Cerebral Cortex; Clonidine; Guanfacine; Guanidines; Phenylacetates; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Tritium | 1983 |
Selectivity of a series of clonidine-like drugs for alpha 1 and alpha 2 adrenoceptors in rat brain.
Topics: Aniline Compounds; Animals; Cerebral Cortex; Clonidine; Guanabenz; Guanfacine; Guanidines; Imidazoles; In Vitro Techniques; Indoramin; Naphazoline; Oxazoles; Phenylacetates; Prazosin; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Structure-Activity Relationship; Thiophenes; Toluidines | 1980 |
Binding of (+/-)-3H-lofexidine to alpha-adrenoceptors in membranes from rat brain.
Topics: Animals; Binding, Competitive; Brain; Clonidine; Kinetics; Male; Membranes; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha | 1983 |
Recent advances in opiate detoxification: clonidine and lofexidine.
Topics: Clonidine; Humans; Methadone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1983 |
Platelet function in hypertension and effect of therapy.
Topics: Adult; Aged; beta-Thromboglobulin; Blood Platelets; Blood Pressure; Clonidine; Heart Rate; Humans; Hypertension; Kidney Function Tests; Male; Middle Aged; Platelet Count; Platelet Function Tests | 1981 |
Comparative efficacy and safety of lofexidine and clonidine in mild to moderately severe systemic hypertension.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Random Allocation | 1984 |
Opiate detoxification using lofexidine.
Topics: Antihypertensive Agents; Clonidine; Humans; Male; Methadone; Opioid-Related Disorders | 1982 |
Lofexidine blocks acute opiate withdrawal.
Topics: Antihypertensive Agents; Clonidine; Humans; Methadone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1982 |
Identification of 2-imidazolines as anti-sickling agents.
Topics: Anemia, Sickle Cell; Antisickling Agents; Clonidine; Gels; Hemoglobin, Sickle; Humans; Imidazoles; Kinetics; Oxyhemoglobins; Structure-Activity Relationship; Tolazoline | 1983 |
Biotransformation of lofexidine in humans.
Topics: Adult; Biotransformation; Chromatography, High Pressure Liquid; Clonidine; Dose-Response Relationship, Drug; Humans; Hydrolysis; Male; Mass Spectrometry | 1983 |
Chemistry of lofexidine.
Topics: Chemical Phenomena; Chemistry; Chemistry, Physical; Clonidine; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy | 1982 |
Characteristics of lofexidine in pharmacological screening.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cats; Clonidine; Coronary Circulation; Dogs; Hemodynamics; Mucous Membrane; Muscle Contraction; Pulse; Renal Circulation | 1982 |
Actions of lofexidine on isolated heart and smooth muscle preparations.
Topics: Animals; Clonidine; Drug Interactions; Guinea Pigs; Heart; Hydrochlorothiazide; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Myocardial Contraction; Norepinephrine; Vas Deferens | 1982 |
Animal experiments on the safety pharmacology of lofexidine.
Topics: Aggression; Anesthetics, Local; Animals; Anticonvulsants; Avoidance Learning; Body Temperature; Central Nervous System; Clonidine; Diuretics; Drug Interactions; Humans; Male; Mice; Motor Activity; Postural Balance; Stomach Ulcer; Time Factors | 1982 |
Animal experiments on the cardiovascular effects of lofexidine.
Topics: Animals; Cats; Clonidine; Dogs; Drug Interactions; Hemodynamics; Hypertension; Hypertension, Renal; Male; Rats; Rats, Inbred Strains; Species Specificity | 1982 |
Acute, subacute and chronic toxicity/Carcinogenicity of lofexidine.
Topics: Animals; Antidotes; Carcinogens; Clonidine; Dogs; Phentolamine; Rats; Rats, Inbred Strains; Tolazoline | 1982 |
Teratologic and reproductive studies of lofexidine.
Topics: Animals; Clonidine; Female; Fertility; Fetus; Male; Pregnancy; Pregnancy, Animal; Rabbits; Rats; Reproduction; Sex Factors; Species Specificity; Teratogens | 1982 |
Toxicology of the combination lofexidine/hydrochlorothiazide.
Topics: Animals; Clonidine; Dogs; Drug Combinations; Female; Hydrochlorothiazide; Male; Pregnancy; Rats; Rats, Inbred Strains; Teratogens | 1982 |
The absorption and excretion of 14C-lofexidine hydrochloride in man.
Topics: Adult; Biotransformation; Blood Proteins; Clonidine; Female; Humans; Intestinal Absorption; Male; Protein Binding; Time Factors | 1982 |
Lofexidine in the treatment of hypertension: a twice-daily versus one-daily dose comparison with 24-hour blood pressure monitoring.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Catecholamines; Clonidine; Drug Administration Schedule; Female; Humans; Hypertension; Male; Middle Aged; Monitoring, Physiologic; Renin | 1981 |
Lofexidine in abrupt methadone withdrawal.
Topics: Clonidine; Humans; Male; Methadone; Substance Withdrawal Syndrome | 1982 |
Effectiveness of lofexidine in blocking morphine-withdrawal signs in the rat.
Topics: Animals; Behavior, Animal; Clonidine; Diarrhea; Dose-Response Relationship, Drug; Humans; Male; Morphine Dependence; Naloxone; Rats; Substance Withdrawal Syndrome | 1980 |
Nonnarcotic antidiarrheal action of clonidine and lofexidine in the rat.
Topics: Animals; Antidiarrheals; Clonidine; Diarrhea; Male; Narcotics; Rats | 1981 |
Opiate detoxification with lofexidine.
Topics: Clonidine; Humans; Methadone; Norepinephrine; Substance Withdrawal Syndrome; Time Factors | 1981 |
Early hemodynamic and humoral effects of lofexidine.
Topics: Adolescent; Adult; Antihypertensive Agents; Catecholamines; Clonidine; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged | 1981 |
Clozapine-induced hypersalivation and the alpha 2 adrenoceptor.
Topics: Antipsychotic Agents; Chronic Disease; Clonidine; Clozapine; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Male; Middle Aged; Receptors, Adrenergic, alpha-2; Schizophrenia; Sialorrhea | 1995 |
Lofexidine based regimen for opiate addicts.
Topics: Clonidine; Humans; Opioid-Related Disorders; Pilot Projects; Substance Withdrawal Syndrome | 1995 |
A naturalistic study of home detoxification from opiates using lofexidine.
Topics: Adult; Clonidine; Female; Heroin Dependence; Humans; Inactivation, Metabolic; Male; Methadone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Treatment Outcome | 1998 |
The use of lofexidine by drug dependency units in the United Kingdom.
Topics: Adolescent; Adult; Clonidine; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Narcotic Antagonists; Opioid-Related Disorders; Substance Abuse Treatment Centers; Surveys and Questionnaires; United Kingdom | 1999 |
Alpha-2 adrenergic receptor agonists block stress-induced reinstatement of cocaine seeking.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Catheterization; Clonidine; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Electric Stimulation; Guanabenz; Infusions, Intravenous; Injections, Intraperitoneal; Male; Microdialysis; Narcotic Antagonists; Norepinephrine; Rats; Rats, Long-Evans; Self Administration; Stress, Physiological; Sucrose | 2000 |
Repeated lofexidine treatment attenuates stress-induced, but not drug cues-induced reinstatement of a heroin-cocaine mixture (speedball) seeking in rats.
Topics: Adrenergic alpha-Agonists; Animals; Body Weight; Clonidine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Drug Combinations; Electroshock; Extinction, Psychological; Heroin Dependence; Male; Rats; Rats, Long-Evans; Self Administration; Stress, Psychological | 2001 |
[Therapy of tic disorders apparently of organic origin in a multi-morbid 5-year-old patient with lofexidine (Britlofex) and clonidine (Catapressan)].
Topics: Affective Symptoms; Aggression; Attention Deficit Disorder with Hyperactivity; Brain Damage, Chronic; Child, Preschool; Clonidine; Comorbidity; Drug Therapy, Combination; Epilepsy; Humans; Male; Tic Disorders | 2001 |
Two methods of community detoxification from opiates: an open-label comparison of lofexidine and buprenorphine.
Topics: Adult; Buprenorphine; Chi-Square Distribution; Clonidine; Community Health Services; Female; Humans; Logistic Models; Male; Narcotic Antagonists; Opioid-Related Disorders; Outcome Assessment, Health Care; Prospective Studies; Statistics, Nonparametric; Substance Withdrawal Syndrome | 2001 |
Major disruptions of sleep during treatment of the opiate withdrawal syndrome: differences between methadone and lofexidine detoxification treatments.
Topics: Clonidine; Humans; Methadone; Narcotic Antagonists; Narcotics; Sleep Wake Disorders; Substance Withdrawal Syndrome; Time Factors | 2003 |
QT interval increased after single dose of lofexidine.
Topics: Adult; Clonidine; Female; Humans; Long QT Syndrome; Methadone; Narcotic Antagonists | 2004 |
Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alcoholism; Animals; Clonidine; Conditioning, Operant; Dose-Response Relationship, Drug; Electroshock; Male; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Reinforcement, Psychology; Self Administration; Stress, Psychological; Yohimbine | 2005 |
Induction of patients with moderately severe methadone dependence onto buprenorphine.
Topics: Adult; Buprenorphine; Clonidine; Drug Administration Schedule; Female; Humans; Male; Methadone; Narcotic Antagonists; Opioid-Related Disorders; Severity of Illness Index; Surveys and Questionnaires | 2005 |
Urine and plasma pharmacokinetics of lofexidine after oral delivery in opiate-dependent patients.
Topics: Administration, Oral; Adult; Analysis of Variance; Area Under Curve; Chromatography, Liquid; Clonidine; Drug Administration Schedule; Half-Life; Humans; Middle Aged; Narcotic Antagonists; Opioid-Related Disorders; Pilot Projects; Tandem Mass Spectrometry | 2009 |
Opioid dependence.
Topics: Buprenorphine; Clonidine; Evidence-Based Medicine; Humans; Inactivation, Metabolic; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Prognosis; Risk Factors; Substance Withdrawal Syndrome; Time Factors | 2012 |
Differential effects of acute and chronic treatment with the α2-adrenergic agonist, lofexidine, on cocaine self-administration in rhesus monkeys.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Behavior, Animal; Catheterization, Peripheral; Clonidine; Cocaine-Related Disorders; Conditioning, Operant; Dose-Response Relationship, Drug; Food; Macaca mulatta; Male; Reinforcement Schedule; Self Administration | 2013 |
Dual effects of α2 -adrenoceptors in modulating myogenic tone in sheep isolated internal anal sphincter.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Anal Canal; Animals; Brimonidine Tartrate; Clonidine; Dexmedetomidine; Muscle Contraction; Prazosin; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha; Sheep; Tissue Culture Techniques | 2014 |
The preclinical discovery of lofexidine for the treatment of opiate addiction.
Topics: Animals; Clonidine; Drug Discovery; Humans; Narcotic Antagonists; Opioid-Related Disorders | 2014 |
Psychometric evaluation of the 10-item Short Opiate Withdrawal Scale-Gossop (SOWS-Gossop) in patients undergoing opioid detoxification.
Topics: Adult; Clonidine; Factor Analysis, Statistical; Female; Humans; Male; Narcotic Antagonists; Opioid-Related Disorders; Psychometrics; Reproducibility of Results; Substance Withdrawal Syndrome; Surveys and Questionnaires | 2016 |
FDA approves nonopioid medication for managing opioid withdrawal.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Clonidine; Drug Approval; Humans; Narcotic Antagonists; Opioid-Related Disorders; Substance Withdrawal Syndrome; United States; United States Food and Drug Administration | 2018 |
Lofexidine (Lucemyra) for opioid withdrawal.
Topics: Clonidine; Drug Approval; Drug Interactions; Humans; Narcotic Antagonists; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome; United States; United States Food and Drug Administration | 2018 |
Management of opioid withdrawal symptoms.
Topics: Adrenergic alpha-2 Receptor Agonists; Buprenorphine; Clonidine; Humans; Methadone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome | 2018 |
Expanded table: Some drugs for management of opioid withdrawal symptoms.
Topics: Adrenergic alpha-2 Receptor Agonists; Buprenorphine; Clonidine; Humans; Methadone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome | 2018 |
Drug updates and approvals: 2018 in review.
Topics: Adenine; Alanine; Amides; Aminophenols; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Benzodioxoles; Clonidine; Doxylamine; Drug Approval; Emtricitabine; Heterocyclic Compounds, 3-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Indoles; Piperazines; Pyridones; Pyridoxine; Quinolones; Tenofovir; United States; United States Food and Drug Administration | 2018 |
Lofexidine (Lucemyra) for Treatment of Opioid Withdrawal Symptoms.
Topics: Adrenergic alpha-2 Receptor Agonists; Clonidine; Dose-Response Relationship, Drug; Humans; Opioid-Related Disorders; Substance Withdrawal Syndrome | 2019 |
New Drugs 2019, part 2.
Topics: Amides; Angiotensin II; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Azetidines; Clonidine; Drug Approval; Heterocyclic Compounds, 3-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Hydrocarbons, Fluorinated; Piperazines; Purines; Pyrazoles; Pyridones; Pyrimidines; Silicates; Sulfonamides; United States; United States Food and Drug Administration | 2019 |