Page last updated: 2024-09-03

loe 908 and nifedipine

loe 908 has been researched along with nifedipine in 10 studies

Compound Research Comparison

Studies
(loe 908)
Trials
(loe 908)
Recent Studies (post-2010)
(loe 908)
Studies
(nifedipine)
Trials
(nifedipine)
Recent Studies (post-2010) (nifedipine)
500516,0242,4961,505

Protein Interaction Comparison

ProteinTaxonomyloe 908 (IC50)nifedipine (IC50)
perilipin-5Homo sapiens (human)7.133
perilipin-1Homo sapiens (human)9.619
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform aHomo sapiens (human)8.376
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)0.0429
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.035
Cytochrome P450 1A2Homo sapiens (human)0.3
Cytochrome P450 3A4Homo sapiens (human)10
Adenosine receptor A3Homo sapiens (human)7.214
Cytochrome P450 2C9 Homo sapiens (human)3.06
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)10
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)7.214
Voltage-dependent L-type calcium channel subunit alpha-1CRattus norvegicus (Norway rat)0.0385
Potassium voltage-gated channel subfamily A member 5Homo sapiens (human)6.1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Rattus norvegicus (Norway rat)1.12
Adenosine receptor A1Homo sapiens (human)7.701
3-oxo-5-alpha-steroid 4-dehydrogenase 2Rattus norvegicus (Norway rat)1.12
C-C chemokine receptor type 2Homo sapiens (human)2.191
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)7.214
Cytochrome P450 2J2Homo sapiens (human)3.06
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.4733
Voltage-dependent L-type calcium channel subunit alpha-1CMus musculus (house mouse)1.2
Voltage-dependent L-type calcium channel subunit alpha-1SMus musculus (house mouse)1.2
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.035
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.0394
Myosin light chain kinase, smooth muscleHomo sapiens (human)2.02
Potassium channel subfamily K member 2 Bos taurus (cattle)8.2
Indoleamine 2,3-dioxygenase 2Mus musculus (house mouse)1.5
Voltage-dependent L-type calcium channel subunit alpha-1DMus musculus (house mouse)1.2
Voltage-dependent L-type calcium channel subunit alpha-1FMus musculus (house mouse)1.2

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (40.00)18.2507
2000's4 (40.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Enoki, T; Furutani, H; Hasegawa, H; Iwamuro, Y; Komuro, T; Lee, K; Masaki, T; Minowa, T; Miwa, S; Okamoto, Y; Okazawa, M; Zhang, XF1
Furutani, H; Hasegawa, H; Iwamuro, Y; Lee, K; Masaki, T; Miwa, S; Morita, H; Nakagawa, T; Okamoto, Y; Zhang, XF1
Iwamuro, Y; Masaki, T; Miwa, S; Okamoto, Y; Zhang, XF1
Inagaki, R; Muramatsu, I; Suzuki, F; Takauji, R; Taniguchi, T1
Hashimoto, N; Kawanabe, Y; Masaki, T; Okamoto, Y1
Hashimoto, N; Kawanabe, Y; Masaki, T2
Horinouchi, T; Jinno, A; Kajita, E; Miwa, S; Miyake, Y; Nishimoto, A; Nishiya, T; Yorozu, S1
Hishinuma, E; Ishida, H; Ishikawa, T; Saito, SY1
Dohi, N; Ishida, H; Ishikawa, T; Saito, SY1

Other Studies

10 other study(ies) available for loe 908 and nifedipine

ArticleYear
Pharmacological characterization of Ca2+ entry channels in endothelin-1-induced contraction of rat aorta using LOE 908 and SK&F 96365.
    British journal of pharmacology, 1999, Volume: 127, Issue:6

    Topics: Acetamides; Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin-1; Imidazoles; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Rats; Rats, Wistar

1999
Pharmacological characterization of receptor-mediated Ca2+ entry in endothelin-1-induced catecholamine release from cultured bovine adrenal chromaffin cells.
    Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 360, Issue:6

    Topics: Acetamides; Adrenal Glands; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cattle; Cells, Cultured; Chromaffin Cells; Dose-Response Relationship, Drug; Endothelin-1; Epinephrine; Imidazoles; Inhibitory Concentration 50; Ion Channels; Isoquinolines; Linear Models; Nifedipine; Norepinephrine; omega-Agatoxin IVA; omega-Conotoxin GVIA; omega-Conotoxins; Receptor, Endothelin A; Receptors, Endothelin; Signal Transduction

1999
[Analysis of Ca2+ entry channels in endothelin-1-induced contraction of rat aorta using new blockers].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1999, Volume: 114 Suppl 1

    Topics: Acetamides; Animals; Aorta, Thoracic; Calcium Channel Blockers; Calcium Channels; Endothelin-1; Imidazoles; In Vitro Techniques; Isoquinolines; Nifedipine; Rats; Vasoconstriction

1999
[Two-phase responses of acid expulsion triggered by alpha-1a adrenoceptor in CHO cell].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1999, Volume: 114 Suppl 1

    Topics: Acetamides; Acids; Amiloride; Animals; Calcium Channel Blockers; CHO Cells; Conotoxins; Cricetinae; Egtazic Acid; Humans; Imidazoles; Isoquinolines; Nifedipine; Norepinephrine; Receptors, Adrenergic, alpha; Verapamil

1999
Characterization of Ca(2+) channels involved in endothelin-1-induced mitogenic responses in vascular smooth muscle cells.
    European journal of pharmacology, 2001, Jun-22, Volume: 422, Issue:1-3

    Topics: Acetamides; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Count; Cell Division; Cell Line; DNA; Dose-Response Relationship, Drug; Endothelin-1; Imidazoles; Isoquinolines; Muscle, Smooth, Vascular; Nifedipine; Time Factors

2001
Extracellular Ca2+ influx and endothelin-1-induced intracellular mitogenic cascades in rabbit internal carotid artery vascular smooth muscle cells.
    Journal of cardiovascular pharmacology, 2002, Volume: 40, Issue:2

    Topics: Acetamides; Animals; Calcium; Calcium Channel Blockers; Carotid Arteries; Cells, Cultured; Drug Interactions; Endothelin-1; Isoquinolines; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Nifedipine; Rabbits

2002
Involvements of voltage-independent Ca2+ channels and phosphoinositide 3-kinase in endothelin-1-induced PYK2 tyrosine phosphorylation.
    Molecular pharmacology, 2003, Volume: 63, Issue:4

    Topics: Acetamides; Androstadienes; Animals; Calcium; Calcium Channels; Cells, Cultured; Chromones; Drug Interactions; Endothelin-1; Enzyme Inhibitors; Focal Adhesion Kinase 2; Imidazoles; Isoquinolines; Morpholines; Muscle, Smooth, Vascular; Nifedipine; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Rabbits; Tyrosine; Wortmannin

2003
Characterization of noradrenaline-induced increases in intracellular Ca2+ levels in Chinese hamster ovary cells stably expressing human alpha1A-adrenoceptor.
    Journal of pharmacological sciences, 2007, Volume: 105, Issue:1

    Topics: Acetamides; Animals; Calcium; Calcium Channels, L-Type; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Estrenes; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Imidazoles; Indoles; Intracellular Fluid; Isoquinolines; Lanthanum; Maleimides; Models, Biological; Nifedipine; Norepinephrine; Peptides, Cyclic; Phosphodiesterase Inhibitors; Protein Kinase C; Pyrrolidinones; Receptors, Adrenergic, alpha-1; Thiourea; Transfection

2007
Differential Contribution of Nerve-Derived Noradrenaline to High K
    Biological & pharmaceutical bulletin, 2017, Volume: 40, Issue:1

    Topics: Acetamides; Adrenergic alpha-1 Receptor Antagonists; Animals; Arteries; Boron Compounds; Calcium; Calcium Channel Blockers; Imidazoles; Ion Channels; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium; Prazosin; Rats, Wistar

2017
Mechanism of Membrane Depolarization Involved in α
    Biological & pharmaceutical bulletin, 2019, Volume: 42, Issue:10

    Topics: Acetamides; Adrenergic alpha-1 Receptor Agonists; Animals; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Iliac Artery; Imidazoles; Isoquinolines; Male; Nifedipine; Phenylephrine; Rats, Wistar; Receptors, Adrenergic, alpha-1; Tail; Tetrahydronaphthalenes; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents

2019