lobelane and pyrrolidine

lobelane has been researched along with pyrrolidine* in 1 studies

Other Studies

1 other study(ies) available for lobelane and pyrrolidine

Article	Year
Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2). Journal of medicinal chemistry, 2009, Dec-10, Volume: 52, Issue:23 Ring size reduction of the central piperidine ring of lobelane yielded pyrrolidine analogues that showed marked inconsistencies in their ability to bind to the dihydrotetrabenazine (DTBZ) binding site on the vesicular monoamine transporter-2 (VMAT2) and their ability to inhibit VMAT2 function. The structure-activity relationships indicate that structural modification within the pyrrolidine series resulted in analogues that interact with two different sites, i.e., the DTBZ binding site and an alternative site on VMAT2 to inhibit transporter function. Topics: Binding Sites; Lobeline; Protein Binding; Pyrrolidines; Structure-Activity Relationship; Tetrabenazine; Vesicular Monoamine Transport Proteins	2009

Article

Year

Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2).

Journal of medicinal chemistry, 2009, Dec-10, Volume: 52, Issue:23

Ring size reduction of the central piperidine ring of lobelane yielded pyrrolidine analogues that showed marked inconsistencies in their ability to bind to the dihydrotetrabenazine (DTBZ) binding site on the vesicular monoamine transporter-2 (VMAT2) and their ability to inhibit VMAT2 function. The structure-activity relationships indicate that structural modification within the pyrrolidine series resulted in analogues that interact with two different sites, i.e., the DTBZ binding site and an alternative site on VMAT2 to inhibit transporter function.

Topics: Binding Sites; Lobeline; Protein Binding; Pyrrolidines; Structure-Activity Relationship; Tetrabenazine; Vesicular Monoamine Transport Proteins

2009