ll-z1640-2 has been researched along with formal-glycol* in 1 studies
1 other study(ies) available for ll-z1640-2 and formal-glycol
Article | Year |
---|---|
Total synthesis of TAK-kinase inhibitor LL-Z1640-2 via consecutive macrocyclization and transannular aromatization.
The biomimetic total synthesis of LL-Z1640-2 (3) is reported without the use of phenol protection. The aromatic unit was constructed via the transannular aromatization of macrocyclic triketo-ester 2, which in turn was synthesized by macrolactonization using an intramolecular trapping of a triketo-ketene derived from dioxinone 1. Topics: Cyclization; Dioxolanes; Lactones; MAP Kinase Kinase Kinases; Molecular Structure; Protein Kinase Inhibitors | 2010 |