Page last updated: 2024-09-05

lixivaptan and tolvaptan

lixivaptan has been researched along with tolvaptan in 33 studies

Compound Research Comparison

Studies (lixivaptan)	Trials (lixivaptan)	Recent Studies (post-2010) (lixivaptan)	Studies (tolvaptan)	Trials (tolvaptan)	Recent Studies (post-2010) (tolvaptan)
80	10	26	967	172	786

Protein Interaction Comparison

Protein	Taxonomy	tolvaptan (IC50)
Bile salt export pump	Homo sapiens (human)	9.99
Vasopressin V2 receptor	Homo sapiens (human)	0.1486
Vasopressin V1a receptor	Homo sapiens (human)	0.351

Research

Studies (33)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	19 (57.58)	29.6817
2010's	13 (39.39)	24.3611
2020's	1 (3.03)	2.80

Authors

Authors	Studies
Thibonnier, M	1
Gheorghiade, M; Orlandi, C; Zimmer, CA	1
Pham, PC; Pham, PM; Pham, PT	1
Greenberg, A; Verbalis, JG	1
Kamyar, M; Lemmens-Gruber, R	1
Gross, P; Herbrig, K; Palm, C; Pistrosch, F	1
Verbalis, JG	1
Omland, T; Solberg, OG	1
Ali, F; Ghali, JK; Guglin, M; Vaitkevicius, P	1
Balk, RA; Patel, GP	1
Kumar, S; Mather, PJ; Rubin, S; Whellan, DJ	1
Haskal, R	1
Hobbs, RE; Tang, WH	1
Schweiger, TA; Zdanowicz, MM	1
Laczi, F	1
Farmakis, D; Filippatos, G; Gheorghiade, M; Kremastinos, DT	1
Boerrigter, G; Burnett, JC; Costello-Boerrigter, LC	1
Goldsmith, SR	1
Haass, M	1
Reilly, T; Schork, MR	1
Ghali, JK; Tam, SW	1
Gafter, U; Gheorghiade, M; Korzets, A; Leibovici, L; Rozen-Zvi, B; Yahav, D	1
Singh, M; Slawsky, MT; Valania, G	1
Cantillo, DS; Comín Colet, J; Robledo, GG	1
Villabona, C	1
Er, F; Fuhr, U; Gassanov, N; Nia, AM; Semmo, M; Semmo, N	1
Dabrowska, MD; Krysiak, R; Okopień, B	1
Dahl, E; Gluud, LL; Kimer, N; Krag, A	1
Greenberg, A; Lehrich, RW; Ortiz-Melo, DI; Patel, MB	1
Kilonzo, K; Lee, JJ; Nistico, A; Yeates, K	1
Iwao, H; Izumi, Y; Miura, K	1
Bhandari, S; Cranston, I; Glanville, J; McCool, R; O'Reilly, K; Peri, A; Petrakova, L; Shaw, A	1
Howell, BA; Pellegrini, L; Shoda, LKM; Woodhead, JL	1

Reviews

32 review(s) available for lixivaptan and tolvaptan

Article	Year
Vasopressin receptor antagonists in heart failure. Current opinion in pharmacology, 2003, Volume: 3, Issue:6 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Pyrroles; Randomized Controlled Trials as Topic; Tolvaptan	2003
Role of vasopressin antagonists in the management of acute decompensated heart failure. Current heart failure reports, 2005, Volume: 2, Issue:3 Topics: Acute Disease; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Pyrroles; Stroke Volume; Tolvaptan; Treatment Outcome; Vasoconstriction; Vasopressins	2005
Vasopressin excess and hyponatremia. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2006, Volume: 47, Issue:5 Topics: Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Humans; Hyponatremia; Pyrroles; Receptors, Vasopressin; Tolvaptan; Water-Electrolyte Balance	2006
Vasopressin receptor antagonists. Kidney international, 2006, Volume: 69, Issue:12 Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Clinical Trials as Topic; Diabetes Insipidus, Nephrogenic; Fibrosis; Heart Failure; Humans; Hyponatremia; Osmolar Concentration; Polycystic Kidney Diseases; Pyrroles; Receptors, Vasopressin; Sodium; Tolvaptan; United States; United States Food and Drug Administration; Vasopressins	2006
Vasopressin antagonists. Cellular and molecular life sciences : CMLS, 2006, Volume: 63, Issue:15 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Binding Sites; Cardiovascular Diseases; Clinical Trials as Topic; Hormone Antagonists; Humans; Indoles; Pyrroles; Pyrrolidines; Tolvaptan; Vasopressins; Water-Electrolyte Imbalance	2006
Vasopressin antagonists as aquaretic agents for the treatment of hyponatremia. The American journal of medicine, 2006, Volume: 119, Issue:7 Suppl 1 Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Humans; Hyponatremia; Inappropriate ADH Syndrome; Morpholines; Pyrroles; Randomized Controlled Trials as Topic; Spiro Compounds; Tolvaptan; Vasopressins	2006
AVP receptor antagonists as aquaretics: review and assessment of clinical data. Cleveland Clinic journal of medicine, 2006, Volume: 73 Suppl 3 Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Humans; Hyponatremia; Pyrroles; Receptors, Vasopressin; Tolvaptan; Water-Electrolyte Balance	2006
[Arginine vasopressin antagonism--new treatment option in chronic heart failure]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2007, Jan-18, Volume: 127, Issue:2 Topics: Animals; Antidiuretic Agents; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Nephrons; Prognosis; Pyrroles; Receptors, Vasopressin; Tolvaptan; Treatment Outcome; Vasoconstrictor Agents	2007
Therapeutic potential of vasopressin receptor antagonists. Drugs, 2007, Volume: 67, Issue:6 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Hyponatremia; Inappropriate ADH Syndrome; Liver Cirrhosis; Morpholines; Pyrroles; Receptors, Vasopressin; Spiro Compounds; Tolvaptan	2007
Recognition and treatment of hyponatremia in acutely ill hospitalized patients. Clinical therapeutics, 2007, Volume: 29, Issue:2 Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Critical Illness; Humans; Hyponatremia; Inpatients; Practice Guidelines as Topic; Pyrroles; Randomized Controlled Trials as Topic; Tolvaptan	2007
Hyponatremia and vasopressin antagonism in congestive heart failure. Clinical cardiology, 2007, Volume: 30, Issue:11 Topics: Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Chronic Disease; Clinical Trials as Topic; Diuretics; Heart Failure; Humans; Hyponatremia; Models, Biological; Pyrroles; Registries; Renin-Angiotensin System; Sodium; Tolvaptan; Treatment Outcome; Vasopressins	2007
Current issues for nurse practitioners: Hyponatremia. Journal of the American Academy of Nurse Practitioners, 2007, Volume: 19, Issue:11 Topics: Aged; Algorithms; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Causality; Decision Trees; Diagnosis, Differential; Early Diagnosis; Female; Homeostasis; Humans; Hyponatremia; Nurse Practitioners; Nurse's Role; Nursing Assessment; Patient Selection; Primary Health Care; Pyrroles; Tolvaptan; Water-Electrolyte Balance	2007
Vasopressin receptor antagonists in heart failure. Recent patents on cardiovascular drug discovery, 2006, Volume: 1, Issue:2 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Pyrroles; Receptors, Vasopressin; Tolvaptan; Vasopressins	2006
Vasopressin-receptor antagonists in heart failure. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2008, May-01, Volume: 65, Issue:9 Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Cardiovascular Agents; Chronic Disease; Heart Failure; Humans; Hyponatremia; Pyrroles; Receptors, Vasopressin; Tolvaptan	2008
[Etiology, diagnostics and therapy of hyponatremias]. Orvosi hetilap, 2008, Jul-20, Volume: 149, Issue:29 Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Blood Volume; Brain Diseases; Central Nervous System; Chronic Disease; Demeclocycline; Demyelinating Diseases; Diagnosis, Differential; Diuretics; Extracellular Fluid; Furosemide; Humans; Hyponatremia; Inappropriate ADH Syndrome; Lithium Compounds; Morpholines; Osmolar Concentration; Osmosis; Pyrroles; Severity of Illness Index; Sodium; Spiro Compounds; Time Factors; Tolvaptan; Vasopressins	2008
Vasopressin and vasopressin antagonists in heart failure and hyponatremia. Current heart failure reports, 2008, Volume: 5, Issue:2 Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Heart Failure; Humans; Hyponatremia; Infusions, Intravenous; Male; Prognosis; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vasopressin; Risk Assessment; Survival Rate; Tolvaptan; Water-Electrolyte Imbalance	2008
Pharmacology of vasopressin antagonists. Heart failure reviews, 2009, Volume: 14, Issue:2 Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Benzodiazepines; Heart Failure; Humans; Morpholines; Pyrroles; Receptors, Vasopressin; Spiro Compounds; Tolvaptan	2009
Treatment options for hyponatremia in heart failure. Heart failure reviews, 2009, Volume: 14, Issue:2 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Hyponatremia; Inappropriate ADH Syndrome; Pyrroles; Sodium Potassium Chloride Symporter Inhibitors; Tolvaptan; Treatment Outcome	2009
[Vasopressin receptor antagonists and heart failure]. Therapeutische Umschau. Revue therapeutique, 2009, Volume: 66, Issue:11 Topics: Administration, Oral; Aged; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Controlled Clinical Trials as Topic; Female; Follow-Up Studies; Furosemide; Heart Failure; Hormone Antagonists; Humans; Hyponatremia; Indoles; Male; Morpholines; Platelet Aggregation Inhibitors; Pyrroles; Pyrrolidines; Sodium Potassium Chloride Symporter Inhibitors; Spiro Compounds; Time Factors; Tolvaptan	2009
Vasopressin antagonists: Pharmacotherapy for the treatment of heart failure. The Annals of pharmacotherapy, 2010, Volume: 44, Issue:4 Topics: Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Hyponatremia; Neurotransmitter Agents; Pyrroles; Tolvaptan; Vasopressins	2010
The critical link of hypervolemia and hyponatremia in heart failure and the potential role of arginine vasopressin antagonists. Journal of cardiac failure, 2010, Volume: 16, Issue:5 Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Benzazepines; Blood Pressure; Blood Volume; Female; Heart Failure; Humans; Hypertension; Hyponatremia; Male; Prevalence; Prognosis; Pyrroles; Receptors, Vasopressin; Tolvaptan; United States; Water-Electrolyte Balance	2010
Vasopressin receptor antagonists for the treatment of hyponatremia: systematic review and meta-analysis. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2010, Volume: 56, Issue:2 Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Humans; Hyponatremia; Morpholines; Pyrroles; Randomized Controlled Trials as Topic; Spiro Compounds; Tolvaptan; Treatment Outcome	2010
Targeting hyponatremia and hemodynamics in acute decompensated heart failure: is there a role for vasopressin antagonists? Current heart failure reports, 2011, Volume: 8, Issue:3 Topics: Acute Disease; Animals; Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Clinical Trials as Topic; Heart Failure; Hemodynamics; Humans; Hyponatremia; Prognosis; Pyrroles; Tolvaptan; Vasoconstriction; Vasopressins	2011
[Hyponatremia in heart failure: physiopathology and pharmacological approach]. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2010, Volume: 57 Suppl 2 Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Benzazepines; Body Water; Brain Edema; Demyelinating Diseases; Diuresis; Diuretics; Double-Blind Method; Heart Failure; Humans; Hyponatremia; Kidney; Multicenter Studies as Topic; Natriuresis; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vasopressin; Renin-Angiotensin System; Saline Solution, Hypertonic; Sympathetic Nervous System; Tolvaptan	2010
[Vasopressin receptor antagonists: the vaptans]. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2010, Volume: 57 Suppl 2 Topics: Adult; Antidiuretic Hormone Receptor Antagonists; Aquaporin 2; Benzamides; Benzazepines; Calcium Signaling; Clinical Trials as Topic; Cyclic AMP; Double-Blind Method; Drug Therapy, Combination; Heart Failure; Humans; Hyponatremia; Inappropriate ADH Syndrome; Kidney Tubules, Collecting; Liver Cirrhosis; Morpholines; Multicenter Studies as Topic; Neoplasms; Pituitary Gland, Anterior; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vasopressin; Second Messenger Systems; Spiro Compounds; Tolvaptan; Vasopressins	2010
Arginine vasopressin (AVP) and treatment with arginine vasopressin receptor antagonists (vaptans) in congestive heart failure, liver cirrhosis and syndrome of inappropriate antidiuretic hormone secretion (SIADH). European journal of clinical pharmacology, 2011, Volume: 67, Issue:4 Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Diuretics; Heart Failure; Humans; Inappropriate ADH Syndrome; Liver Cirrhosis; Models, Biological; Morpholines; Pyrroles; Spiro Compounds; Tolvaptan; Water-Electrolyte Balance	2011
[Hyponatremic hypervolemia in heart failure--the hot spot for vasopressin receptor antagonists?]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 2012, Volume: 65, Issue:1 Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Diuretics; Heart Failure; Humans; Hyponatremia; Hypovolemia; Morpholines; Pyrroles; Spiro Compounds; Tolvaptan	2012
Meta-analysis: the safety and efficacy of vaptans (tolvaptan, satavaptan and lixivaptan) in cirrhosis with ascites or hyponatraemia. Alimentary pharmacology & therapeutics, 2012, Volume: 36, Issue:7 Topics: Antidiuretic Hormone Receptor Antagonists; Ascites; Benzamides; Benzazepines; Humans; Hyponatremia; Liver Cirrhosis; Morpholines; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vasopressin; Sodium; Spiro Compounds; Tolvaptan; Treatment Outcome	2012
Role of vaptans in the management of hyponatremia. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2013, Volume: 62, Issue:2 Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Humans; Hyponatremia; Male; Middle Aged; Pyrroles; Tolvaptan	2013
Management of hyponatremia. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2014, May-13, Volume: 186, Issue:8 Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Disease Management; Female; Humans; Hyponatremia; Hypovolemia; Inappropriate ADH Syndrome; Male; Morpholines; Prognosis; Pyrroles; Receptors, Vasopressin; Risk Assessment; Severity of Illness Index; Spiro Compounds; Tolvaptan; Treatment Outcome	2014
Therapeutic potential of vasopressin-receptor antagonists in heart failure. Journal of pharmacological sciences, 2014, Volume: 124, Issue:1 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Benzazepines; Body Water; Clinical Trials as Topic; Disease Models, Animal; Heart Failure; Homeostasis; Humans; Hyponatremia; Morpholines; Pyrroles; Receptors, Vasopressin; Spiro Compounds; Tolvaptan; Ventricular Remodeling	2014
A systematic review of known interventions for the treatment of chronic nonhypovolaemic hypotonic hyponatraemia and a meta-analysis of the vaptans. Clinical endocrinology, 2017, Volume: 86, Issue:6 Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Humans; Hyponatremia; Morpholines; Osmotic Pressure; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vasopressin; Spiro Compounds; Tolvaptan	2017

Other Studies

1 other study(ies) available for lixivaptan and tolvaptan

Article	Year
Comparison of the Hepatotoxic Potential of Two Treatments for Autosomal-Dominant Polycystic Kidney DiseaseUsing Quantitative Systems Toxicology Modeling. Pharmaceutical research, 2020, Jan-06, Volume: 37, Issue:2 Topics: Benzamides; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Humans; Models, Theoretical; Polycystic Kidney, Autosomal Dominant; Pyrroles; Tolvaptan	2020

Article

Year

Comparison of the Hepatotoxic Potential of Two Treatments for Autosomal-Dominant Polycystic Kidney DiseaseUsing Quantitative Systems Toxicology Modeling.

Pharmaceutical research, 2020, Jan-06, Volume: 37, Issue:2

Topics: Benzamides; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Humans; Models, Theoretical; Polycystic Kidney, Autosomal Dominant; Pyrroles; Tolvaptan

2020