lixivaptan has been researched along with pyrroles in 69 studies
Studies (lixivaptan) | Trials (lixivaptan) | Recent Studies (post-2010) (lixivaptan) | Studies (pyrroles) | Trials (pyrroles) | Recent Studies (post-2010) (pyrroles) |
---|---|---|---|---|---|
80 | 10 | 26 | 26,129 | 2,815 | 12,100 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 5 (7.25) | 18.2507 |
2000's | 34 (49.28) | 29.6817 |
2010's | 27 (39.13) | 24.3611 |
2020's | 3 (4.35) | 2.80 |
Authors | Studies |
---|---|
Albright, JD; Bailey, T; Chan, PS; Coupet, J; Delos Santos, EG; Dusza, JP; Mazandarani, H; Reich, MF; Ru, X; Sum, FW; Venkatesan, AM | 1 |
Albright, JD; Bailey, T; Cervoni, P; Chan, PS; Coupet, J; Dusza, JP; Hartupee, D; Lai, F; Lock, TY; Mazandarani, H; Ning, X; Ochalski, L; Park, HC; Ru, X; Shepherd, C; Spinelli, W; Tanikella, T; Taylor, JR | 1 |
Albright, JD; Aranapakam, V; Chan, PS; Coupet, J; Grosu, GT; Mazandarani, H; Ru, X; Saunders, T | 1 |
Albright, JD; Aranapakam, V; Chan, PS; Coupet, J; Delos Santos, EG; Grosu, GT; Mazandarani, H; Ru, X; Saunders, T | 1 |
Abraham, WT; Lieming, X; Martin, PY; Ohara, M; Olson, BR; Oren, RM; Schrier, RW | 1 |
Angers, S; Arthus, MF; Bernier, V; Bichet, DG; Bouvier, M; Laperrière, A; Lonergan, M; Morello, JP; Morin, D; Petäjä-Repo, U; Salahpour, A | 1 |
Ashwell, MA; Bagli, JF; Caggiano, TJ; Chan, PS; Molinari, AJ; Palka, C; Park, CH; Rogers, JF; Sherman, M; Trybulski, EJ; Williams, DK | 1 |
Gross, P; Palm, C | 1 |
Arieff, AI | 1 |
Decaux, G | 3 |
Martinez-Castelao, A | 1 |
Ellis-Grosse, EJ; Guyader, D; Orczyk, GP; Patat, A | 1 |
Blei, AT; Blendis, LM; Thuluvath, PJ; Wong, F | 1 |
Ferguson, JW; Hayes, PC; Newby, DE; Therapondos, G | 1 |
Decaux, G; Djian, J; Gandjini, H; Gerbes, AL; Ginès, P; Gross, P; Gülberg, V | 1 |
Chen, RH; Demarest, KT; Ericson, E; Gunnet, J; Look, R; Murray, WV; Rybczynski, PJ; Urbanski, MJ; Zhang, X | 1 |
Thibonnier, M | 1 |
Gheorghiade, M; Orlandi, C; Zimmer, CA | 1 |
Pham, PC; Pham, PM; Pham, PT | 1 |
Greenberg, A; Verbalis, JG | 1 |
Kamyar, M; Lemmens-Gruber, R | 1 |
Gross, P; Herbrig, K; Palm, C; Pistrosch, F | 1 |
Verbalis, JG | 1 |
Omland, T; Solberg, OG | 1 |
Ali, F; Ghali, JK; Guglin, M; Vaitkevicius, P | 1 |
Balk, RA; Patel, GP | 1 |
Kumar, S; Mather, PJ; Rubin, S; Whellan, DJ | 1 |
Ali, K; Bagli, J; Cochran, D; Considine, J; Croce, S; Demaio, W; Lihotz, L; Molinari, AJ; Qi, J; Trybulski, EJ | 1 |
Haskal, R | 1 |
Hobbs, RE; Tang, WH | 1 |
Schweiger, TA; Zdanowicz, MM | 1 |
Laczi, F | 1 |
Farmakis, D; Filippatos, G; Gheorghiade, M; Kremastinos, DT | 1 |
Boerrigter, G; Burnett, JC; Costello-Boerrigter, LC | 1 |
Kumar, SK; Mather, PJ | 1 |
Goldsmith, SR | 1 |
Campese, VM; Ku, E; Nobakht, N | 1 |
Haass, M | 1 |
Reilly, T; Schork, MR | 1 |
Ghali, JK; Tam, SW | 1 |
Gafter, U; Gheorghiade, M; Korzets, A; Leibovici, L; Rozen-Zvi, B; Yahav, D | 1 |
Abraham, WT; Aranda, JM; Boehmer, JP; Elkayam, U; Feldman, AM; Gilbert, EM; Gottlieb, SS; Hasenfuss, G; Kukin, M; Lowes, BD; O'Connell, JB; Orlandi, C; Tavazzi, L; Ticho, B | 1 |
Singh, M; Slawsky, MT; Valania, G | 1 |
Daifallah, S; Farah, JO; Ghali, JK; Zmily, HD | 1 |
Cantillo, DS; Comín Colet, J; Robledo, GG | 1 |
Villabona, C | 1 |
Er, F; Fuhr, U; Gassanov, N; Nia, AM; Semmo, M; Semmo, N | 1 |
Daifallah, S; Ghali, JK; Khan, NS; Zmily, HD | 1 |
Klunk, L; Li, Z; Orlandi, C; Prakash, C | 1 |
Abraham, WT; Ghali, JK; Orlandi, C | 1 |
Dabrowska, MD; Krysiak, R; Okopień, B | 1 |
Dahl, E; Gluud, LL; Kimer, N; Krag, A | 1 |
Abraham, WT; Bichet, DG; Chafekar, DS; Gross, PA; Hensen, J; Josiassen, RC; Orlandi, C | 1 |
Abraham, WT; Bichet, DG; Decaux, G; Josiassen, RC; Kopyt, N; Mannelli, M; Orlandi, C; Thacker, HP; Yagil, Y | 1 |
Rosner, MH | 1 |
Borne, RT; Krantz, MJ | 1 |
Alani, A; Ghali, JK; Zmily, HD | 1 |
Greenberg, A; Lehrich, RW; Ortiz-Melo, DI; Patel, MB | 1 |
Kilonzo, K; Lee, JJ; Nistico, A; Yeates, K | 1 |
Iwao, H; Izumi, Y; Miura, K | 1 |
Elisaf, MS; Filippatos, TD; Liamis, G | 1 |
Couturier, BS; Decaux, G; Gankam Kengne, F; Soupart, A | 1 |
Bhandari, S; Cranston, I; Glanville, J; McCool, R; O'Reilly, K; Peri, A; Petrakova, L; Shaw, A | 1 |
Chebib, FT; Constans, MM; Pellegrini, L; Torres, VE; Wang, X | 1 |
Centrone, M; Di Mise, A; Pellegrini, L; Ranieri, M; Tamma, G; Valenti, G; Venneri, M | 1 |
Howell, BA; Pellegrini, L; Shoda, LKM; Woodhead, JL | 1 |
Di Mise, A; Pellegrini, L; Torres, VE; Valenti, G; Wang, X; Ye, H | 1 |
43 review(s) available for lixivaptan and pyrroles
Article | Year |
---|---|
VPA-985, a nonpeptide orally active and selective vasopressin V2 receptor antagonist.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Blood Pressure; Cyclic AMP; Dogs; Heart Failure; Humans; Hyponatremia; Inappropriate ADH Syndrome; Kidney; Pyrroles; Receptors, Vasopressin | 1998 |
The treatment of hyponatraemia using vasopressin antagonists.
Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Humans; Hyponatremia; Morpholines; Pyrroles; Receptors, Vasopressin; Spiro Compounds; Vasopressins | 2000 |
Treatment of hyponatremic encephalopathy with antagonists to antidiuretic hormone.
Topics: Azepines; Benzamides; Brain Diseases, Metabolic; Humans; Hyponatremia; Inappropriate ADH Syndrome; Liver Cirrhosis; Pyrroles; Vasopressins | 2001 |
Lixivaptan (American Home Products).
Topics: Animals; Azepines; Benzamides; Clinical Trials as Topic; Humans; Hyponatremia; Pyrroles; Structure-Activity Relationship; Vasopressins | 2001 |
Therapeutic role of vasopressin receptor antagonism in patients with liver cirrhosis.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Controlled Clinical Trials as Topic; Diuretics; Heart Failure; Homeostasis; Humans; Inappropriate ADH Syndrome; Liver Cirrhosis; Models, Animal; Morpholines; Piperidines; Pyrroles; Quinolones; Rats; Spiro Compounds; Vasopressins | 2003 |
Vasopressin receptor antagonists in heart failure.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Pyrroles; Randomized Controlled Trials as Topic; Tolvaptan | 2003 |
Role of vasopressin antagonists in the management of acute decompensated heart failure.
Topics: Acute Disease; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Pyrroles; Stroke Volume; Tolvaptan; Treatment Outcome; Vasoconstriction; Vasopressins | 2005 |
Vasopressin excess and hyponatremia.
Topics: Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Humans; Hyponatremia; Pyrroles; Receptors, Vasopressin; Tolvaptan; Water-Electrolyte Balance | 2006 |
Vasopressin receptor antagonists.
Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Clinical Trials as Topic; Diabetes Insipidus, Nephrogenic; Fibrosis; Heart Failure; Humans; Hyponatremia; Osmolar Concentration; Polycystic Kidney Diseases; Pyrroles; Receptors, Vasopressin; Sodium; Tolvaptan; United States; United States Food and Drug Administration; Vasopressins | 2006 |
Vasopressin antagonists.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Binding Sites; Cardiovascular Diseases; Clinical Trials as Topic; Hormone Antagonists; Humans; Indoles; Pyrroles; Pyrrolidines; Tolvaptan; Vasopressins; Water-Electrolyte Imbalance | 2006 |
Vasopressin antagonists as aquaretic agents for the treatment of hyponatremia.
Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Humans; Hyponatremia; Inappropriate ADH Syndrome; Morpholines; Pyrroles; Randomized Controlled Trials as Topic; Spiro Compounds; Tolvaptan; Vasopressins | 2006 |
AVP receptor antagonists as aquaretics: review and assessment of clinical data.
Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Humans; Hyponatremia; Pyrroles; Receptors, Vasopressin; Tolvaptan; Water-Electrolyte Balance | 2006 |
[Arginine vasopressin antagonism--new treatment option in chronic heart failure].
Topics: Animals; Antidiuretic Agents; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Nephrons; Prognosis; Pyrroles; Receptors, Vasopressin; Tolvaptan; Treatment Outcome; Vasoconstrictor Agents | 2007 |
Therapeutic potential of vasopressin receptor antagonists.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Hyponatremia; Inappropriate ADH Syndrome; Liver Cirrhosis; Morpholines; Pyrroles; Receptors, Vasopressin; Spiro Compounds; Tolvaptan | 2007 |
Recognition and treatment of hyponatremia in acutely ill hospitalized patients.
Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Critical Illness; Humans; Hyponatremia; Inpatients; Practice Guidelines as Topic; Pyrroles; Randomized Controlled Trials as Topic; Tolvaptan | 2007 |
Hyponatremia and vasopressin antagonism in congestive heart failure.
Topics: Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Chronic Disease; Clinical Trials as Topic; Diuretics; Heart Failure; Humans; Hyponatremia; Models, Biological; Pyrroles; Registries; Renin-Angiotensin System; Sodium; Tolvaptan; Treatment Outcome; Vasopressins | 2007 |
Current issues for nurse practitioners: Hyponatremia.
Topics: Aged; Algorithms; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Causality; Decision Trees; Diagnosis, Differential; Early Diagnosis; Female; Homeostasis; Humans; Hyponatremia; Nurse Practitioners; Nurse's Role; Nursing Assessment; Patient Selection; Primary Health Care; Pyrroles; Tolvaptan; Water-Electrolyte Balance | 2007 |
Vasopressin receptor antagonists in heart failure.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Pyrroles; Receptors, Vasopressin; Tolvaptan; Vasopressins | 2006 |
Vasopressin-receptor antagonists in heart failure.
Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Cardiovascular Agents; Chronic Disease; Heart Failure; Humans; Hyponatremia; Pyrroles; Receptors, Vasopressin; Tolvaptan | 2008 |
[Etiology, diagnostics and therapy of hyponatremias].
Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Blood Volume; Brain Diseases; Central Nervous System; Chronic Disease; Demeclocycline; Demyelinating Diseases; Diagnosis, Differential; Diuretics; Extracellular Fluid; Furosemide; Humans; Hyponatremia; Inappropriate ADH Syndrome; Lithium Compounds; Morpholines; Osmolar Concentration; Osmosis; Pyrroles; Severity of Illness Index; Sodium; Spiro Compounds; Time Factors; Tolvaptan; Vasopressins | 2008 |
Vasopressin and vasopressin antagonists in heart failure and hyponatremia.
Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Heart Failure; Humans; Hyponatremia; Infusions, Intravenous; Male; Prognosis; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vasopressin; Risk Assessment; Survival Rate; Tolvaptan; Water-Electrolyte Imbalance | 2008 |
Pharmacology of vasopressin antagonists.
Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Benzodiazepines; Heart Failure; Humans; Morpholines; Pyrroles; Receptors, Vasopressin; Spiro Compounds; Tolvaptan | 2009 |
AVP receptor antagonists in patients with CHF.
Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Hyponatremia; Pyrroles; Receptors, Vasopressin; Sodium | 2009 |
Treatment options for hyponatremia in heart failure.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Hyponatremia; Inappropriate ADH Syndrome; Pyrroles; Sodium Potassium Chloride Symporter Inhibitors; Tolvaptan; Treatment Outcome | 2009 |
Lixivaptan: a novel vasopressin receptor antagonist.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Clinical Trials, Phase III as Topic; Heart Failure; Humans; Kidney Diseases; Pyrroles; Receptors, Vasopressin | 2009 |
[Vasopressin receptor antagonists and heart failure].
Topics: Administration, Oral; Aged; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Controlled Clinical Trials as Topic; Female; Follow-Up Studies; Furosemide; Heart Failure; Hormone Antagonists; Humans; Hyponatremia; Indoles; Male; Morpholines; Platelet Aggregation Inhibitors; Pyrroles; Pyrrolidines; Sodium Potassium Chloride Symporter Inhibitors; Spiro Compounds; Time Factors; Tolvaptan | 2009 |
Vasopressin antagonists: Pharmacotherapy for the treatment of heart failure.
Topics: Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Hyponatremia; Neurotransmitter Agents; Pyrroles; Tolvaptan; Vasopressins | 2010 |
The critical link of hypervolemia and hyponatremia in heart failure and the potential role of arginine vasopressin antagonists.
Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Benzazepines; Blood Pressure; Blood Volume; Female; Heart Failure; Humans; Hypertension; Hyponatremia; Male; Prevalence; Prognosis; Pyrroles; Receptors, Vasopressin; Tolvaptan; United States; Water-Electrolyte Balance | 2010 |
Vasopressin receptor antagonists for the treatment of hyponatremia: systematic review and meta-analysis.
Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Humans; Hyponatremia; Morpholines; Pyrroles; Randomized Controlled Trials as Topic; Spiro Compounds; Tolvaptan; Treatment Outcome | 2010 |
Targeting hyponatremia and hemodynamics in acute decompensated heart failure: is there a role for vasopressin antagonists?
Topics: Acute Disease; Animals; Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Clinical Trials as Topic; Heart Failure; Hemodynamics; Humans; Hyponatremia; Prognosis; Pyrroles; Tolvaptan; Vasoconstriction; Vasopressins | 2011 |
Lixivaptan, a non-peptide vasopressin V2 receptor antagonist for the potential oral treatment of hyponatremia.
Topics: Administration, Oral; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Clinical Trials as Topic; Dogs; Heart Failure; Humans; Hyponatremia; Pyrroles; Rats | 2010 |
[Hyponatremia in heart failure: physiopathology and pharmacological approach].
Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Benzazepines; Body Water; Brain Edema; Demyelinating Diseases; Diuresis; Diuretics; Double-Blind Method; Heart Failure; Humans; Hyponatremia; Kidney; Multicenter Studies as Topic; Natriuresis; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vasopressin; Renin-Angiotensin System; Saline Solution, Hypertonic; Sympathetic Nervous System; Tolvaptan | 2010 |
[Vasopressin receptor antagonists: the vaptans].
Topics: Adult; Antidiuretic Hormone Receptor Antagonists; Aquaporin 2; Benzamides; Benzazepines; Calcium Signaling; Clinical Trials as Topic; Cyclic AMP; Double-Blind Method; Drug Therapy, Combination; Heart Failure; Humans; Hyponatremia; Inappropriate ADH Syndrome; Kidney Tubules, Collecting; Liver Cirrhosis; Morpholines; Multicenter Studies as Topic; Neoplasms; Pituitary Gland, Anterior; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vasopressin; Second Messenger Systems; Spiro Compounds; Tolvaptan; Vasopressins | 2010 |
Arginine vasopressin (AVP) and treatment with arginine vasopressin receptor antagonists (vaptans) in congestive heart failure, liver cirrhosis and syndrome of inappropriate antidiuretic hormone secretion (SIADH).
Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Diuretics; Heart Failure; Humans; Inappropriate ADH Syndrome; Liver Cirrhosis; Models, Biological; Morpholines; Pyrroles; Spiro Compounds; Tolvaptan; Water-Electrolyte Balance | 2011 |
The potential role for lixivaptan in heart failure and in hyponatremia.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Heart Failure; Humans; Hyponatremia; Plasma Volume; Pyrroles | 2011 |
[Hyponatremic hypervolemia in heart failure--the hot spot for vasopressin receptor antagonists?].
Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Diuretics; Heart Failure; Humans; Hyponatremia; Hypovolemia; Morpholines; Pyrroles; Spiro Compounds; Tolvaptan | 2012 |
Meta-analysis: the safety and efficacy of vaptans (tolvaptan, satavaptan and lixivaptan) in cirrhosis with ascites or hyponatraemia.
Topics: Antidiuretic Hormone Receptor Antagonists; Ascites; Benzamides; Benzazepines; Humans; Hyponatremia; Liver Cirrhosis; Morpholines; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vasopressin; Sodium; Spiro Compounds; Tolvaptan; Treatment Outcome | 2012 |
Evaluation of lixivaptan in euvolemic and hypervolemic hyponatremia and heart failure treatment.
Topics: Animals; Benzamides; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation; Electrolytes; Heart Failure; Humans; Hyponatremia; Outpatients; Pyrroles; Receptors, Vasopressin; Sodium; Treatment Outcome | 2013 |
Role of vaptans in the management of hyponatremia.
Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Humans; Hyponatremia; Male; Middle Aged; Pyrroles; Tolvaptan | 2013 |
Management of hyponatremia.
Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Disease Management; Female; Humans; Hyponatremia; Hypovolemia; Inappropriate ADH Syndrome; Male; Morpholines; Prognosis; Pyrroles; Receptors, Vasopressin; Risk Assessment; Severity of Illness Index; Spiro Compounds; Tolvaptan; Treatment Outcome | 2014 |
Therapeutic potential of vasopressin-receptor antagonists in heart failure.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Benzazepines; Body Water; Clinical Trials as Topic; Disease Models, Animal; Heart Failure; Homeostasis; Humans; Hyponatremia; Morpholines; Pyrroles; Receptors, Vasopressin; Spiro Compounds; Tolvaptan; Ventricular Remodeling | 2014 |
Treatment of hyponatremia: the role of lixivaptan.
Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Hyponatremia; Pyrroles; Randomized Controlled Trials as Topic; Sodium | 2014 |
A systematic review of known interventions for the treatment of chronic nonhypovolaemic hypotonic hyponatraemia and a meta-analysis of the vaptans.
Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Humans; Hyponatremia; Morpholines; Osmotic Pressure; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vasopressin; Spiro Compounds; Tolvaptan | 2017 |
10 trial(s) available for lixivaptan and pyrroles
Article | Year |
---|---|
5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]-[1, 4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985): an orally active arginine vasopressin antagonist with selectivity for V2 receptors.
Topics: Administration, Oral; Animals; Arginine Vasopressin; Azepines; Benzamides; Blood Platelets; Body Water; Cell Line; Cell Membrane; Dogs; Fibroblasts; Humans; Kidney; Liver; Osmolar Concentration; Pyrroles; Rats; Receptors, Vasopressin; Sodium; Structure-Activity Relationship; Urine | 1998 |
Selective V2-receptor vasopressin antagonism decreases urinary aquaporin-2 excretion in patients with chronic heart failure.
Topics: Administration, Oral; Aged; Aquaporin 2; Aquaporin 6; Aquaporins; Arginine Vasopressin; Azepines; Benzamides; Biomarkers; Blotting, Western; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Failure; Humans; Male; Middle Aged; Pyrroles; Reference Values; Sensitivity and Specificity | 1999 |
Difference in solute excretion during correction of hyponatremic patients with cirrhosis or syndrome of inappropriate secretion of antidiuretic hormone by oral vasopressin V2 receptor antagonist VPA-985.
Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Diuresis; Humans; Hyponatremia; Inappropriate ADH Syndrome; Liver Cirrhosis; Osmolar Concentration; Potassium; Pyrroles; Sodium; Urea; Uric Acid; Water; Water-Electrolyte Balance | 2001 |
Pharmacodynamic effects of a nonpeptide antidiuretic hormone V2 antagonist in cirrhotic patients with ascites.
Topics: Adult; Aged; Antidiuretic Hormone Receptor Antagonists; Ascites; Azepines; Benzamides; Double-Blind Method; Drinking; Electrolytes; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Osmolar Concentration; Pyrroles; Renin; Sodium; Urine; Urodynamics; Vasopressins; Water; Water-Electrolyte Balance | 2002 |
A vasopressin receptor antagonist (VPA-985) improves serum sodium concentration in patients with hyponatremia: a multicenter, randomized, placebo-controlled trial.
Topics: Aldosterone; Antidiuretic Hormone Receptor Antagonists; Ascites; Azepines; Benzamides; Edema; Female; Heart Failure; Hemodynamics; Humans; Hyponatremia; Inappropriate ADH Syndrome; Liver Cirrhosis; Male; Middle Aged; Norepinephrine; Pyrroles; Renin; Sodium; Thirst; Treatment Outcome; Water-Electrolyte Balance | 2003 |
Therapy of hyponatremia in cirrhosis with a vasopressin receptor antagonist: a randomized double-blind multicenter trial.
Topics: Antidiuretic Hormone Receptor Antagonists; Ascites; Azepines; Benzamides; Blood Pressure; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; Hyponatremia; Kidney; Liver Cirrhosis; Male; Middle Aged; Pyrroles; Sodium; Treatment Outcome; Water | 2003 |
Rationale and design of the treatment of hyponatremia based on lixivaptan in NYHA class III/IV cardiac patient evaluation (THE BALANCE) study.
Topics: Benzamides; Endpoint Determination; Humans; Hyponatremia; Pyrroles | 2010 |
The efficacy and safety of lixivaptan in outpatients with heart failure and volume overload: results of a multicentre, randomized, double-blind, placebo-controlled, parallel-group study.
Topics: Adult; Aged; Aged, 80 and over; Antidiuretic Hormone Receptor Antagonists; Benzamides; Body Weight; Double-Blind Method; Female; Health Status Indicators; Heart Failure; Humans; Hyponatremia; Male; Middle Aged; Outpatients; Pyrroles; Statistics as Topic; Stroke Volume; Ventricular Function, Left; Young Adult | 2012 |
Lixivaptan safely and effectively corrects serum sodium concentrations in hospitalized patients with euvolemic hyponatremia.
Topics: Adult; Aged; Aged, 80 and over; Benzamides; Double-Blind Method; Female; Hospitalization; Humans; Hyponatremia; Male; Middle Aged; Pyrroles; Sodium; Treatment Outcome | 2012 |
Oral lixivaptan effectively increases serum sodium concentrations in outpatients with euvolemic hyponatremia.
Topics: Adult; Aged; Aged, 80 and over; Benzamides; Double-Blind Method; Female; Humans; Hyponatremia; Long-Term Care; Male; Middle Aged; Nursing Homes; Pyrroles; Sodium; Treatment Outcome; Young Adult | 2012 |
16 other study(ies) available for lixivaptan and pyrroles
Article | Year |
---|---|
4,10-dihydro-5H-thieno[3,2-c][1]benzazepine derivatives and 9,10-dihydro-4H-thieno[2,3-c][1]benzazepine derivatives as orally active arginine vasopressin receptor antagonists.
Topics: Administration, Oral; Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Fibroblasts; Inhibitory Concentration 50; Mice; Pyrroles; Structure-Activity Relationship; Thiophenes | 1999 |
5-fluoro-2-methyl-N-[5-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-yl carbonyl)-2-pyridinyl]benzamide (CL-385004) and analogs as orally active arginine vasopressin receptor antagonists.
Topics: Aminopyridines; Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzodiazepines; Inhibitory Concentration 50; Kidney; Liver; Pyrroles; Rats | 1999 |
Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Cell Line; Cell Membrane; COS Cells; Diabetes Insipidus, Nephrogenic; Flow Cytometry; Humans; Intracellular Fluid; Molecular Chaperones; Morpholines; Mutagenesis; Protein Folding; Pyrroles; Receptors, Vasopressin; Spiro Compounds | 2000 |
The design, synthesis and physical chemical properties of novel human vasopressin V2-receptor antagonists optimized for parenteral delivery.
Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzodiazepines; Humans; Infusions, Parenteral; Pyrroles; Structure-Activity Relationship | 2000 |
Treatment of hyponatremic encephalopathy.
Topics: Azepines; Benzamides; Brain Diseases, Metabolic; Humans; Hyponatremia; Inappropriate ADH Syndrome; Liver Cirrhosis; Pyrroles; Receptors, Vasopressin; Sodium Chloride | 2001 |
2,5-disubstituted 3,4-dihydro-2H-benzo[b][1,4]thiazepines as potent and selective V2 arginine vasopressin receptor antagonists.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Dibenzothiazepines; Diuresis; Drug Design; Kinetics; Male; Pyrroles; Rats; Structure-Activity Relationship | 2003 |
Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan.
Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Humans; In Vitro Techniques; Pyrroles; Receptors, Vasopressin | 2007 |
Assessment of exposure of metabolites in preclinical species and humans at steady state from the single-dose radiolabeled absorption, distribution, metabolism, and excretion studies: a case study.
Topics: Absorption; Adolescent; Adult; Animals; Area Under Curve; Benzamides; Carbon Radioisotopes; Case-Control Studies; Chromatography, High Pressure Liquid; Dogs; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Inactivation, Metabolic; Male; Metabolome; Middle Aged; Pyrroles; Rats; Rats, Sprague-Dawley; Young Adult | 2012 |
Lixivaptan: a vasopressin receptor antagonist for the treatment of hyponatremia.
Topics: Benzamides; Female; Humans; Hyponatremia; Male; Pyrroles; Sodium | 2012 |
Lixivaptan for hyponatremia--the numbers game.
Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Biomarkers; Data Interpretation, Statistical; Drug Approval; Heart Failure; Humans; Hyponatremia; Length of Stay; Pyrroles; Risk; Severity of Illness Index; Sodium; Treatment Outcome; United States; United States Food and Drug Administration | 2012 |
Urea minimizes brain complications following rapid correction of chronic hyponatremia compared with vasopressin antagonist or hypertonic saline.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Astrocytes; Benzamides; Blood-Brain Barrier; Brain Diseases; Chronic Disease; Demyelinating Diseases; Hyponatremia; Male; Microglia; Pyrroles; Rats; Rats, Wistar; Saline Solution, Hypertonic; Urea | 2015 |
Effect of a Vasopressin V2 Receptor Antagonist on Polycystic Kidney Disease Development in a Rat Model.
Topics: Administration, Oral; Animals; Antidiuretic Hormone Receptor Antagonists; Benzamides; Creatinine; Cysts; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Kidney; Liver; Liver Diseases; Mutation; Organ Size; Polycystic Kidney, Autosomal Dominant; Pyrroles; Rats; Receptors, Cell Surface; Receptors, Vasopressin | 2019 |
Lixivaptan, a New Generation Diuretic, Counteracts Vasopressin-Induced Aquaporin-2 Trafficking and Function in Renal Collecting Duct Cells.
Topics: Animals; Aquaporin 2; Benzamides; Cell Line; Deamino Arginine Vasopressin; Diuretics; Gene Expression Regulation; Kidney Tubules, Collecting; Mice; Phosphorylation; Pyrroles; Receptors, Vasopressin; Signal Transduction | 2019 |
Comparison of the Hepatotoxic Potential of Two Treatments for Autosomal-Dominant Polycystic Kidney DiseaseUsing Quantitative Systems Toxicology Modeling.
Topics: Benzamides; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Humans; Models, Theoretical; Polycystic Kidney, Autosomal Dominant; Pyrroles; Tolvaptan | 2020 |
Pre-clinical evaluation of dual targeting of the GPCRs CaSR and V2R as therapeutic strategy for autosomal dominant polycystic kidney disease.
Topics: Animals; Benzamides; Cyclic AMP; Drug Therapy, Combination; Female; Male; Mice; Mice, Inbred C57BL; Phenethylamines; Polycystic Kidney, Autosomal Dominant; Propylamines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Calcium-Sensing; Receptors, Vasopressin | 2021 |
Low Creatininuria due to Hyponatremia Is Reversible in Many Patients.
Topics: Adult; Aged; Benzamides; Creatinine; Deamino Arginine Vasopressin; Female; Humans; Hyponatremia; Male; Middle Aged; Pyrroles; Retrospective Studies | 2022 |