Page last updated: 2024-09-05

lixivaptan and pyrroles

lixivaptan has been researched along with pyrroles in 69 studies

Compound Research Comparison

Studies
(lixivaptan)
Trials
(lixivaptan)
Recent Studies (post-2010)
(lixivaptan)
Studies
(pyrroles)
Trials
(pyrroles)
Recent Studies (post-2010) (pyrroles)
80102626,1292,81512,100

Research

Studies (69)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (7.25)18.2507
2000's34 (49.28)29.6817
2010's27 (39.13)24.3611
2020's3 (4.35)2.80

Authors

AuthorsStudies
Albright, JD; Bailey, T; Chan, PS; Coupet, J; Delos Santos, EG; Dusza, JP; Mazandarani, H; Reich, MF; Ru, X; Sum, FW; Venkatesan, AM1
Albright, JD; Bailey, T; Cervoni, P; Chan, PS; Coupet, J; Dusza, JP; Hartupee, D; Lai, F; Lock, TY; Mazandarani, H; Ning, X; Ochalski, L; Park, HC; Ru, X; Shepherd, C; Spinelli, W; Tanikella, T; Taylor, JR1
Albright, JD; Aranapakam, V; Chan, PS; Coupet, J; Grosu, GT; Mazandarani, H; Ru, X; Saunders, T1
Albright, JD; Aranapakam, V; Chan, PS; Coupet, J; Delos Santos, EG; Grosu, GT; Mazandarani, H; Ru, X; Saunders, T1
Abraham, WT; Lieming, X; Martin, PY; Ohara, M; Olson, BR; Oren, RM; Schrier, RW1
Angers, S; Arthus, MF; Bernier, V; Bichet, DG; Bouvier, M; Laperrière, A; Lonergan, M; Morello, JP; Morin, D; Petäjä-Repo, U; Salahpour, A1
Ashwell, MA; Bagli, JF; Caggiano, TJ; Chan, PS; Molinari, AJ; Palka, C; Park, CH; Rogers, JF; Sherman, M; Trybulski, EJ; Williams, DK1
Gross, P; Palm, C1
Arieff, AI1
Decaux, G3
Martinez-Castelao, A1
Ellis-Grosse, EJ; Guyader, D; Orczyk, GP; Patat, A1
Blei, AT; Blendis, LM; Thuluvath, PJ; Wong, F1
Ferguson, JW; Hayes, PC; Newby, DE; Therapondos, G1
Decaux, G; Djian, J; Gandjini, H; Gerbes, AL; Ginès, P; Gross, P; Gülberg, V1
Chen, RH; Demarest, KT; Ericson, E; Gunnet, J; Look, R; Murray, WV; Rybczynski, PJ; Urbanski, MJ; Zhang, X1
Thibonnier, M1
Gheorghiade, M; Orlandi, C; Zimmer, CA1
Pham, PC; Pham, PM; Pham, PT1
Greenberg, A; Verbalis, JG1
Kamyar, M; Lemmens-Gruber, R1
Gross, P; Herbrig, K; Palm, C; Pistrosch, F1
Verbalis, JG1
Omland, T; Solberg, OG1
Ali, F; Ghali, JK; Guglin, M; Vaitkevicius, P1
Balk, RA; Patel, GP1
Kumar, S; Mather, PJ; Rubin, S; Whellan, DJ1
Ali, K; Bagli, J; Cochran, D; Considine, J; Croce, S; Demaio, W; Lihotz, L; Molinari, AJ; Qi, J; Trybulski, EJ1
Haskal, R1
Hobbs, RE; Tang, WH1
Schweiger, TA; Zdanowicz, MM1
Laczi, F1
Farmakis, D; Filippatos, G; Gheorghiade, M; Kremastinos, DT1
Boerrigter, G; Burnett, JC; Costello-Boerrigter, LC1
Kumar, SK; Mather, PJ1
Goldsmith, SR1
Campese, VM; Ku, E; Nobakht, N1
Haass, M1
Reilly, T; Schork, MR1
Ghali, JK; Tam, SW1
Gafter, U; Gheorghiade, M; Korzets, A; Leibovici, L; Rozen-Zvi, B; Yahav, D1
Abraham, WT; Aranda, JM; Boehmer, JP; Elkayam, U; Feldman, AM; Gilbert, EM; Gottlieb, SS; Hasenfuss, G; Kukin, M; Lowes, BD; O'Connell, JB; Orlandi, C; Tavazzi, L; Ticho, B1
Singh, M; Slawsky, MT; Valania, G1
Daifallah, S; Farah, JO; Ghali, JK; Zmily, HD1
Cantillo, DS; Comín Colet, J; Robledo, GG1
Villabona, C1
Er, F; Fuhr, U; Gassanov, N; Nia, AM; Semmo, M; Semmo, N1
Daifallah, S; Ghali, JK; Khan, NS; Zmily, HD1
Klunk, L; Li, Z; Orlandi, C; Prakash, C1
Abraham, WT; Ghali, JK; Orlandi, C1
Dabrowska, MD; Krysiak, R; Okopień, B1
Dahl, E; Gluud, LL; Kimer, N; Krag, A1
Abraham, WT; Bichet, DG; Chafekar, DS; Gross, PA; Hensen, J; Josiassen, RC; Orlandi, C1
Abraham, WT; Bichet, DG; Decaux, G; Josiassen, RC; Kopyt, N; Mannelli, M; Orlandi, C; Thacker, HP; Yagil, Y1
Rosner, MH1
Borne, RT; Krantz, MJ1
Alani, A; Ghali, JK; Zmily, HD1
Greenberg, A; Lehrich, RW; Ortiz-Melo, DI; Patel, MB1
Kilonzo, K; Lee, JJ; Nistico, A; Yeates, K1
Iwao, H; Izumi, Y; Miura, K1
Elisaf, MS; Filippatos, TD; Liamis, G1
Couturier, BS; Decaux, G; Gankam Kengne, F; Soupart, A1
Bhandari, S; Cranston, I; Glanville, J; McCool, R; O'Reilly, K; Peri, A; Petrakova, L; Shaw, A1
Chebib, FT; Constans, MM; Pellegrini, L; Torres, VE; Wang, X1
Centrone, M; Di Mise, A; Pellegrini, L; Ranieri, M; Tamma, G; Valenti, G; Venneri, M1
Howell, BA; Pellegrini, L; Shoda, LKM; Woodhead, JL1
Di Mise, A; Pellegrini, L; Torres, VE; Valenti, G; Wang, X; Ye, H1

Reviews

43 review(s) available for lixivaptan and pyrroles

ArticleYear
VPA-985, a nonpeptide orally active and selective vasopressin V2 receptor antagonist.
    Advances in experimental medicine and biology, 1998, Volume: 449

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Blood Pressure; Cyclic AMP; Dogs; Heart Failure; Humans; Hyponatremia; Inappropriate ADH Syndrome; Kidney; Pyrroles; Receptors, Vasopressin

1998
The treatment of hyponatraemia using vasopressin antagonists.
    Experimental physiology, 2000, Volume: 85 Spec No

    Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Humans; Hyponatremia; Morpholines; Pyrroles; Receptors, Vasopressin; Spiro Compounds; Vasopressins

2000
Treatment of hyponatremic encephalopathy with antagonists to antidiuretic hormone.
    The Journal of laboratory and clinical medicine, 2001, Volume: 138, Issue:1

    Topics: Azepines; Benzamides; Brain Diseases, Metabolic; Humans; Hyponatremia; Inappropriate ADH Syndrome; Liver Cirrhosis; Pyrroles; Vasopressins

2001
Lixivaptan (American Home Products).
    Current opinion in investigational drugs (London, England : 2000), 2001, Volume: 2, Issue:4

    Topics: Animals; Azepines; Benzamides; Clinical Trials as Topic; Humans; Hyponatremia; Pyrroles; Structure-Activity Relationship; Vasopressins

2001
Therapeutic role of vasopressin receptor antagonism in patients with liver cirrhosis.
    Clinical science (London, England : 1979), 2003, Volume: 105, Issue:1

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Controlled Clinical Trials as Topic; Diuretics; Heart Failure; Homeostasis; Humans; Inappropriate ADH Syndrome; Liver Cirrhosis; Models, Animal; Morpholines; Piperidines; Pyrroles; Quinolones; Rats; Spiro Compounds; Vasopressins

2003
Vasopressin receptor antagonists in heart failure.
    Current opinion in pharmacology, 2003, Volume: 3, Issue:6

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Pyrroles; Randomized Controlled Trials as Topic; Tolvaptan

2003
Role of vasopressin antagonists in the management of acute decompensated heart failure.
    Current heart failure reports, 2005, Volume: 2, Issue:3

    Topics: Acute Disease; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Pyrroles; Stroke Volume; Tolvaptan; Treatment Outcome; Vasoconstriction; Vasopressins

2005
Vasopressin excess and hyponatremia.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2006, Volume: 47, Issue:5

    Topics: Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Humans; Hyponatremia; Pyrroles; Receptors, Vasopressin; Tolvaptan; Water-Electrolyte Balance

2006
Vasopressin receptor antagonists.
    Kidney international, 2006, Volume: 69, Issue:12

    Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Clinical Trials as Topic; Diabetes Insipidus, Nephrogenic; Fibrosis; Heart Failure; Humans; Hyponatremia; Osmolar Concentration; Polycystic Kidney Diseases; Pyrroles; Receptors, Vasopressin; Sodium; Tolvaptan; United States; United States Food and Drug Administration; Vasopressins

2006
Vasopressin antagonists.
    Cellular and molecular life sciences : CMLS, 2006, Volume: 63, Issue:15

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Binding Sites; Cardiovascular Diseases; Clinical Trials as Topic; Hormone Antagonists; Humans; Indoles; Pyrroles; Pyrrolidines; Tolvaptan; Vasopressins; Water-Electrolyte Imbalance

2006
Vasopressin antagonists as aquaretic agents for the treatment of hyponatremia.
    The American journal of medicine, 2006, Volume: 119, Issue:7 Suppl 1

    Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Humans; Hyponatremia; Inappropriate ADH Syndrome; Morpholines; Pyrroles; Randomized Controlled Trials as Topic; Spiro Compounds; Tolvaptan; Vasopressins

2006
AVP receptor antagonists as aquaretics: review and assessment of clinical data.
    Cleveland Clinic journal of medicine, 2006, Volume: 73 Suppl 3

    Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Humans; Hyponatremia; Pyrroles; Receptors, Vasopressin; Tolvaptan; Water-Electrolyte Balance

2006
[Arginine vasopressin antagonism--new treatment option in chronic heart failure].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2007, Jan-18, Volume: 127, Issue:2

    Topics: Animals; Antidiuretic Agents; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Nephrons; Prognosis; Pyrroles; Receptors, Vasopressin; Tolvaptan; Treatment Outcome; Vasoconstrictor Agents

2007
Therapeutic potential of vasopressin receptor antagonists.
    Drugs, 2007, Volume: 67, Issue:6

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Hyponatremia; Inappropriate ADH Syndrome; Liver Cirrhosis; Morpholines; Pyrroles; Receptors, Vasopressin; Spiro Compounds; Tolvaptan

2007
Recognition and treatment of hyponatremia in acutely ill hospitalized patients.
    Clinical therapeutics, 2007, Volume: 29, Issue:2

    Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Critical Illness; Humans; Hyponatremia; Inpatients; Practice Guidelines as Topic; Pyrroles; Randomized Controlled Trials as Topic; Tolvaptan

2007
Hyponatremia and vasopressin antagonism in congestive heart failure.
    Clinical cardiology, 2007, Volume: 30, Issue:11

    Topics: Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Chronic Disease; Clinical Trials as Topic; Diuretics; Heart Failure; Humans; Hyponatremia; Models, Biological; Pyrroles; Registries; Renin-Angiotensin System; Sodium; Tolvaptan; Treatment Outcome; Vasopressins

2007
Current issues for nurse practitioners: Hyponatremia.
    Journal of the American Academy of Nurse Practitioners, 2007, Volume: 19, Issue:11

    Topics: Aged; Algorithms; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Causality; Decision Trees; Diagnosis, Differential; Early Diagnosis; Female; Homeostasis; Humans; Hyponatremia; Nurse Practitioners; Nurse's Role; Nursing Assessment; Patient Selection; Primary Health Care; Pyrroles; Tolvaptan; Water-Electrolyte Balance

2007
Vasopressin receptor antagonists in heart failure.
    Recent patents on cardiovascular drug discovery, 2006, Volume: 1, Issue:2

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Pyrroles; Receptors, Vasopressin; Tolvaptan; Vasopressins

2006
Vasopressin-receptor antagonists in heart failure.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2008, May-01, Volume: 65, Issue:9

    Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Cardiovascular Agents; Chronic Disease; Heart Failure; Humans; Hyponatremia; Pyrroles; Receptors, Vasopressin; Tolvaptan

2008
[Etiology, diagnostics and therapy of hyponatremias].
    Orvosi hetilap, 2008, Jul-20, Volume: 149, Issue:29

    Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Blood Volume; Brain Diseases; Central Nervous System; Chronic Disease; Demeclocycline; Demyelinating Diseases; Diagnosis, Differential; Diuretics; Extracellular Fluid; Furosemide; Humans; Hyponatremia; Inappropriate ADH Syndrome; Lithium Compounds; Morpholines; Osmolar Concentration; Osmosis; Pyrroles; Severity of Illness Index; Sodium; Spiro Compounds; Time Factors; Tolvaptan; Vasopressins

2008
Vasopressin and vasopressin antagonists in heart failure and hyponatremia.
    Current heart failure reports, 2008, Volume: 5, Issue:2

    Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Heart Failure; Humans; Hyponatremia; Infusions, Intravenous; Male; Prognosis; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vasopressin; Risk Assessment; Survival Rate; Tolvaptan; Water-Electrolyte Imbalance

2008
Pharmacology of vasopressin antagonists.
    Heart failure reviews, 2009, Volume: 14, Issue:2

    Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Benzodiazepines; Heart Failure; Humans; Morpholines; Pyrroles; Receptors, Vasopressin; Spiro Compounds; Tolvaptan

2009
AVP receptor antagonists in patients with CHF.
    Heart failure reviews, 2009, Volume: 14, Issue:2

    Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Hyponatremia; Pyrroles; Receptors, Vasopressin; Sodium

2009
Treatment options for hyponatremia in heart failure.
    Heart failure reviews, 2009, Volume: 14, Issue:2

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Hyponatremia; Inappropriate ADH Syndrome; Pyrroles; Sodium Potassium Chloride Symporter Inhibitors; Tolvaptan; Treatment Outcome

2009
Lixivaptan: a novel vasopressin receptor antagonist.
    Expert opinion on investigational drugs, 2009, Volume: 18, Issue:5

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Clinical Trials, Phase III as Topic; Heart Failure; Humans; Kidney Diseases; Pyrroles; Receptors, Vasopressin

2009
[Vasopressin receptor antagonists and heart failure].
    Therapeutische Umschau. Revue therapeutique, 2009, Volume: 66, Issue:11

    Topics: Administration, Oral; Aged; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Controlled Clinical Trials as Topic; Female; Follow-Up Studies; Furosemide; Heart Failure; Hormone Antagonists; Humans; Hyponatremia; Indoles; Male; Morpholines; Platelet Aggregation Inhibitors; Pyrroles; Pyrrolidines; Sodium Potassium Chloride Symporter Inhibitors; Spiro Compounds; Time Factors; Tolvaptan

2009
Vasopressin antagonists: Pharmacotherapy for the treatment of heart failure.
    The Annals of pharmacotherapy, 2010, Volume: 44, Issue:4

    Topics: Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Hyponatremia; Neurotransmitter Agents; Pyrroles; Tolvaptan; Vasopressins

2010
The critical link of hypervolemia and hyponatremia in heart failure and the potential role of arginine vasopressin antagonists.
    Journal of cardiac failure, 2010, Volume: 16, Issue:5

    Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Benzazepines; Blood Pressure; Blood Volume; Female; Heart Failure; Humans; Hypertension; Hyponatremia; Male; Prevalence; Prognosis; Pyrroles; Receptors, Vasopressin; Tolvaptan; United States; Water-Electrolyte Balance

2010
Vasopressin receptor antagonists for the treatment of hyponatremia: systematic review and meta-analysis.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2010, Volume: 56, Issue:2

    Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Humans; Hyponatremia; Morpholines; Pyrroles; Randomized Controlled Trials as Topic; Spiro Compounds; Tolvaptan; Treatment Outcome

2010
Targeting hyponatremia and hemodynamics in acute decompensated heart failure: is there a role for vasopressin antagonists?
    Current heart failure reports, 2011, Volume: 8, Issue:3

    Topics: Acute Disease; Animals; Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Clinical Trials as Topic; Heart Failure; Hemodynamics; Humans; Hyponatremia; Prognosis; Pyrroles; Tolvaptan; Vasoconstriction; Vasopressins

2011
Lixivaptan, a non-peptide vasopressin V2 receptor antagonist for the potential oral treatment of hyponatremia.
    IDrugs : the investigational drugs journal, 2010, Volume: 13, Issue:11

    Topics: Administration, Oral; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Clinical Trials as Topic; Dogs; Heart Failure; Humans; Hyponatremia; Pyrroles; Rats

2010
[Hyponatremia in heart failure: physiopathology and pharmacological approach].
    Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2010, Volume: 57 Suppl 2

    Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Benzazepines; Body Water; Brain Edema; Demyelinating Diseases; Diuresis; Diuretics; Double-Blind Method; Heart Failure; Humans; Hyponatremia; Kidney; Multicenter Studies as Topic; Natriuresis; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vasopressin; Renin-Angiotensin System; Saline Solution, Hypertonic; Sympathetic Nervous System; Tolvaptan

2010
[Vasopressin receptor antagonists: the vaptans].
    Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2010, Volume: 57 Suppl 2

    Topics: Adult; Antidiuretic Hormone Receptor Antagonists; Aquaporin 2; Benzamides; Benzazepines; Calcium Signaling; Clinical Trials as Topic; Cyclic AMP; Double-Blind Method; Drug Therapy, Combination; Heart Failure; Humans; Hyponatremia; Inappropriate ADH Syndrome; Kidney Tubules, Collecting; Liver Cirrhosis; Morpholines; Multicenter Studies as Topic; Neoplasms; Pituitary Gland, Anterior; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vasopressin; Second Messenger Systems; Spiro Compounds; Tolvaptan; Vasopressins

2010
Arginine vasopressin (AVP) and treatment with arginine vasopressin receptor antagonists (vaptans) in congestive heart failure, liver cirrhosis and syndrome of inappropriate antidiuretic hormone secretion (SIADH).
    European journal of clinical pharmacology, 2011, Volume: 67, Issue:4

    Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Diuretics; Heart Failure; Humans; Inappropriate ADH Syndrome; Liver Cirrhosis; Models, Biological; Morpholines; Pyrroles; Spiro Compounds; Tolvaptan; Water-Electrolyte Balance

2011
The potential role for lixivaptan in heart failure and in hyponatremia.
    Expert opinion on investigational drugs, 2011, Volume: 20, Issue:6

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Heart Failure; Humans; Hyponatremia; Plasma Volume; Pyrroles

2011
[Hyponatremic hypervolemia in heart failure--the hot spot for vasopressin receptor antagonists?].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 2012, Volume: 65, Issue:1

    Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Diuretics; Heart Failure; Humans; Hyponatremia; Hypovolemia; Morpholines; Pyrroles; Spiro Compounds; Tolvaptan

2012
Meta-analysis: the safety and efficacy of vaptans (tolvaptan, satavaptan and lixivaptan) in cirrhosis with ascites or hyponatraemia.
    Alimentary pharmacology & therapeutics, 2012, Volume: 36, Issue:7

    Topics: Antidiuretic Hormone Receptor Antagonists; Ascites; Benzamides; Benzazepines; Humans; Hyponatremia; Liver Cirrhosis; Morpholines; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vasopressin; Sodium; Spiro Compounds; Tolvaptan; Treatment Outcome

2012
Evaluation of lixivaptan in euvolemic and hypervolemic hyponatremia and heart failure treatment.
    Expert opinion on drug metabolism & toxicology, 2013, Volume: 9, Issue:5

    Topics: Animals; Benzamides; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation; Electrolytes; Heart Failure; Humans; Hyponatremia; Outpatients; Pyrroles; Receptors, Vasopressin; Sodium; Treatment Outcome

2013
Role of vaptans in the management of hyponatremia.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2013, Volume: 62, Issue:2

    Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Humans; Hyponatremia; Male; Middle Aged; Pyrroles; Tolvaptan

2013
Management of hyponatremia.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2014, May-13, Volume: 186, Issue:8

    Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Disease Management; Female; Humans; Hyponatremia; Hypovolemia; Inappropriate ADH Syndrome; Male; Morpholines; Prognosis; Pyrroles; Receptors, Vasopressin; Risk Assessment; Severity of Illness Index; Spiro Compounds; Tolvaptan; Treatment Outcome

2014
Therapeutic potential of vasopressin-receptor antagonists in heart failure.
    Journal of pharmacological sciences, 2014, Volume: 124, Issue:1

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Benzazepines; Body Water; Clinical Trials as Topic; Disease Models, Animal; Heart Failure; Homeostasis; Humans; Hyponatremia; Morpholines; Pyrroles; Receptors, Vasopressin; Spiro Compounds; Tolvaptan; Ventricular Remodeling

2014
Treatment of hyponatremia: the role of lixivaptan.
    Expert review of clinical pharmacology, 2014, Volume: 7, Issue:4

    Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Hyponatremia; Pyrroles; Randomized Controlled Trials as Topic; Sodium

2014
A systematic review of known interventions for the treatment of chronic nonhypovolaemic hypotonic hyponatraemia and a meta-analysis of the vaptans.
    Clinical endocrinology, 2017, Volume: 86, Issue:6

    Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Humans; Hyponatremia; Morpholines; Osmotic Pressure; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vasopressin; Spiro Compounds; Tolvaptan

2017

Trials

10 trial(s) available for lixivaptan and pyrroles

ArticleYear
5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]-[1, 4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985): an orally active arginine vasopressin antagonist with selectivity for V2 receptors.
    Journal of medicinal chemistry, 1998, Jul-02, Volume: 41, Issue:14

    Topics: Administration, Oral; Animals; Arginine Vasopressin; Azepines; Benzamides; Blood Platelets; Body Water; Cell Line; Cell Membrane; Dogs; Fibroblasts; Humans; Kidney; Liver; Osmolar Concentration; Pyrroles; Rats; Receptors, Vasopressin; Sodium; Structure-Activity Relationship; Urine

1998
Selective V2-receptor vasopressin antagonism decreases urinary aquaporin-2 excretion in patients with chronic heart failure.
    Journal of the American Society of Nephrology : JASN, 1999, Volume: 10, Issue:10

    Topics: Administration, Oral; Aged; Aquaporin 2; Aquaporin 6; Aquaporins; Arginine Vasopressin; Azepines; Benzamides; Biomarkers; Blotting, Western; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Failure; Humans; Male; Middle Aged; Pyrroles; Reference Values; Sensitivity and Specificity

1999
Difference in solute excretion during correction of hyponatremic patients with cirrhosis or syndrome of inappropriate secretion of antidiuretic hormone by oral vasopressin V2 receptor antagonist VPA-985.
    The Journal of laboratory and clinical medicine, 2001, Volume: 138, Issue:1

    Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Diuresis; Humans; Hyponatremia; Inappropriate ADH Syndrome; Liver Cirrhosis; Osmolar Concentration; Potassium; Pyrroles; Sodium; Urea; Uric Acid; Water; Water-Electrolyte Balance

2001
Pharmacodynamic effects of a nonpeptide antidiuretic hormone V2 antagonist in cirrhotic patients with ascites.
    Hepatology (Baltimore, Md.), 2002, Volume: 36, Issue:5

    Topics: Adult; Aged; Antidiuretic Hormone Receptor Antagonists; Ascites; Azepines; Benzamides; Double-Blind Method; Drinking; Electrolytes; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Osmolar Concentration; Pyrroles; Renin; Sodium; Urine; Urodynamics; Vasopressins; Water; Water-Electrolyte Balance

2002
A vasopressin receptor antagonist (VPA-985) improves serum sodium concentration in patients with hyponatremia: a multicenter, randomized, placebo-controlled trial.
    Hepatology (Baltimore, Md.), 2003, Volume: 37, Issue:1

    Topics: Aldosterone; Antidiuretic Hormone Receptor Antagonists; Ascites; Azepines; Benzamides; Edema; Female; Heart Failure; Hemodynamics; Humans; Hyponatremia; Inappropriate ADH Syndrome; Liver Cirrhosis; Male; Middle Aged; Norepinephrine; Pyrroles; Renin; Sodium; Thirst; Treatment Outcome; Water-Electrolyte Balance

2003
Therapy of hyponatremia in cirrhosis with a vasopressin receptor antagonist: a randomized double-blind multicenter trial.
    Gastroenterology, 2003, Volume: 124, Issue:4

    Topics: Antidiuretic Hormone Receptor Antagonists; Ascites; Azepines; Benzamides; Blood Pressure; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; Hyponatremia; Kidney; Liver Cirrhosis; Male; Middle Aged; Pyrroles; Sodium; Treatment Outcome; Water

2003
Rationale and design of the treatment of hyponatremia based on lixivaptan in NYHA class III/IV cardiac patient evaluation (THE BALANCE) study.
    Clinical and translational science, 2010, Volume: 3, Issue:5

    Topics: Benzamides; Endpoint Determination; Humans; Hyponatremia; Pyrroles

2010
The efficacy and safety of lixivaptan in outpatients with heart failure and volume overload: results of a multicentre, randomized, double-blind, placebo-controlled, parallel-group study.
    European journal of heart failure, 2012, Volume: 14, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antidiuretic Hormone Receptor Antagonists; Benzamides; Body Weight; Double-Blind Method; Female; Health Status Indicators; Heart Failure; Humans; Hyponatremia; Male; Middle Aged; Outpatients; Pyrroles; Statistics as Topic; Stroke Volume; Ventricular Function, Left; Young Adult

2012
Lixivaptan safely and effectively corrects serum sodium concentrations in hospitalized patients with euvolemic hyponatremia.
    Kidney international, 2012, Volume: 82, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Benzamides; Double-Blind Method; Female; Hospitalization; Humans; Hyponatremia; Male; Middle Aged; Pyrroles; Sodium; Treatment Outcome

2012
Oral lixivaptan effectively increases serum sodium concentrations in outpatients with euvolemic hyponatremia.
    Kidney international, 2012, Volume: 82, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Benzamides; Double-Blind Method; Female; Humans; Hyponatremia; Long-Term Care; Male; Middle Aged; Nursing Homes; Pyrroles; Sodium; Treatment Outcome; Young Adult

2012

Other Studies

16 other study(ies) available for lixivaptan and pyrroles

ArticleYear
4,10-dihydro-5H-thieno[3,2-c][1]benzazepine derivatives and 9,10-dihydro-4H-thieno[2,3-c][1]benzazepine derivatives as orally active arginine vasopressin receptor antagonists.
    Bioorganic & medicinal chemistry letters, 1999, Jul-05, Volume: 9, Issue:13

    Topics: Administration, Oral; Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Fibroblasts; Inhibitory Concentration 50; Mice; Pyrroles; Structure-Activity Relationship; Thiophenes

1999
5-fluoro-2-methyl-N-[5-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-yl carbonyl)-2-pyridinyl]benzamide (CL-385004) and analogs as orally active arginine vasopressin receptor antagonists.
    Bioorganic & medicinal chemistry letters, 1999, Jul-05, Volume: 9, Issue:13

    Topics: Aminopyridines; Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzodiazepines; Inhibitory Concentration 50; Kidney; Liver; Pyrroles; Rats

1999
Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants.
    The Journal of clinical investigation, 2000, Volume: 105, Issue:7

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Cell Line; Cell Membrane; COS Cells; Diabetes Insipidus, Nephrogenic; Flow Cytometry; Humans; Intracellular Fluid; Molecular Chaperones; Morpholines; Mutagenesis; Protein Folding; Pyrroles; Receptors, Vasopressin; Spiro Compounds

2000
The design, synthesis and physical chemical properties of novel human vasopressin V2-receptor antagonists optimized for parenteral delivery.
    Bioorganic & medicinal chemistry letters, 2000, Apr-17, Volume: 10, Issue:8

    Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzodiazepines; Humans; Infusions, Parenteral; Pyrroles; Structure-Activity Relationship

2000
Treatment of hyponatremic encephalopathy.
    The Journal of laboratory and clinical medicine, 2001, Volume: 138, Issue:6

    Topics: Azepines; Benzamides; Brain Diseases, Metabolic; Humans; Hyponatremia; Inappropriate ADH Syndrome; Liver Cirrhosis; Pyrroles; Receptors, Vasopressin; Sodium Chloride

2001
2,5-disubstituted 3,4-dihydro-2H-benzo[b][1,4]thiazepines as potent and selective V2 arginine vasopressin receptor antagonists.
    Bioorganic & medicinal chemistry letters, 2003, Nov-17, Volume: 13, Issue:22

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Dibenzothiazepines; Diuresis; Drug Design; Kinetics; Male; Pyrroles; Rats; Structure-Activity Relationship

2003
Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan.
    Bioorganic & medicinal chemistry letters, 2007, Nov-01, Volume: 17, Issue:21

    Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Humans; In Vitro Techniques; Pyrroles; Receptors, Vasopressin

2007
Assessment of exposure of metabolites in preclinical species and humans at steady state from the single-dose radiolabeled absorption, distribution, metabolism, and excretion studies: a case study.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:7

    Topics: Absorption; Adolescent; Adult; Animals; Area Under Curve; Benzamides; Carbon Radioisotopes; Case-Control Studies; Chromatography, High Pressure Liquid; Dogs; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Inactivation, Metabolic; Male; Metabolome; Middle Aged; Pyrroles; Rats; Rats, Sprague-Dawley; Young Adult

2012
Lixivaptan: a vasopressin receptor antagonist for the treatment of hyponatremia.
    Kidney international, 2012, Volume: 82, Issue:11

    Topics: Benzamides; Female; Humans; Hyponatremia; Male; Pyrroles; Sodium

2012
Lixivaptan for hyponatremia--the numbers game.
    JAMA, 2012, Dec-12, Volume: 308, Issue:22

    Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Biomarkers; Data Interpretation, Statistical; Drug Approval; Heart Failure; Humans; Hyponatremia; Length of Stay; Pyrroles; Risk; Severity of Illness Index; Sodium; Treatment Outcome; United States; United States Food and Drug Administration

2012
Urea minimizes brain complications following rapid correction of chronic hyponatremia compared with vasopressin antagonist or hypertonic saline.
    Kidney international, 2015, Volume: 87, Issue:2

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Astrocytes; Benzamides; Blood-Brain Barrier; Brain Diseases; Chronic Disease; Demyelinating Diseases; Hyponatremia; Male; Microglia; Pyrroles; Rats; Rats, Wistar; Saline Solution, Hypertonic; Urea

2015
Effect of a Vasopressin V2 Receptor Antagonist on Polycystic Kidney Disease Development in a Rat Model.
    American journal of nephrology, 2019, Volume: 49, Issue:6

    Topics: Administration, Oral; Animals; Antidiuretic Hormone Receptor Antagonists; Benzamides; Creatinine; Cysts; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Kidney; Liver; Liver Diseases; Mutation; Organ Size; Polycystic Kidney, Autosomal Dominant; Pyrroles; Rats; Receptors, Cell Surface; Receptors, Vasopressin

2019
Lixivaptan, a New Generation Diuretic, Counteracts Vasopressin-Induced Aquaporin-2 Trafficking and Function in Renal Collecting Duct Cells.
    International journal of molecular sciences, 2019, Dec-26, Volume: 21, Issue:1

    Topics: Animals; Aquaporin 2; Benzamides; Cell Line; Deamino Arginine Vasopressin; Diuretics; Gene Expression Regulation; Kidney Tubules, Collecting; Mice; Phosphorylation; Pyrroles; Receptors, Vasopressin; Signal Transduction

2019
Comparison of the Hepatotoxic Potential of Two Treatments for Autosomal-Dominant Polycystic Kidney DiseaseUsing Quantitative Systems Toxicology Modeling.
    Pharmaceutical research, 2020, Jan-06, Volume: 37, Issue:2

    Topics: Benzamides; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Humans; Models, Theoretical; Polycystic Kidney, Autosomal Dominant; Pyrroles; Tolvaptan

2020
Pre-clinical evaluation of dual targeting of the GPCRs CaSR and V2R as therapeutic strategy for autosomal dominant polycystic kidney disease.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:10

    Topics: Animals; Benzamides; Cyclic AMP; Drug Therapy, Combination; Female; Male; Mice; Mice, Inbred C57BL; Phenethylamines; Polycystic Kidney, Autosomal Dominant; Propylamines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Calcium-Sensing; Receptors, Vasopressin

2021
Low Creatininuria due to Hyponatremia Is Reversible in Many Patients.
    Nephron, 2022, Volume: 146, Issue:1

    Topics: Adult; Aged; Benzamides; Creatinine; Deamino Arginine Vasopressin; Female; Humans; Hyponatremia; Male; Middle Aged; Pyrroles; Retrospective Studies

2022