Compounds > lixivaptan
Page last updated: 2024-09-05

lixivaptan and arginine vasopressin

lixivaptan has been researched along with arginine vasopressin in 23 studies

Compound Research Comparison

Studies
(lixivaptan)		Trials
(lixivaptan)		Recent Studies (post-2010)
(lixivaptan)		Studies
(arginine vasopressin)		Trials
(arginine vasopressin)		Recent Studies (post-2010) (arginine vasopressin)
80102612,2784221,212

Protein Interaction Comparison

ProteinTaxonomylixivaptan (IC50)arginine vasopressin (IC50)
Vasopressin V2 receptorHomo sapiens (human)0.242

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (13.04)18.2507
2000's15 (65.22)29.6817
2010's5 (21.74)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Double-Cazanave, E; Garcia, C; Guillon, G; Maffrand, JP; Pascal, M; Raufaste, D; Serradeil-Le Gal, C1
Albright, JD; Bailey, T; Chan, PS; Coupet, J; Delos Santos, EG; Dusza, JP; Mazandarani, H; Reich, MF; Ru, X; Sum, FW; Venkatesan, AM1
Albright, JD; Bailey, T; Cervoni, P; Chan, PS; Coupet, J; Dusza, JP; Hartupee, D; Lai, F; Lock, TY; Mazandarani, H; Ning, X; Ochalski, L; Park, HC; Ru, X; Shepherd, C; Spinelli, W; Tanikella, T; Taylor, JR1
Abraham, WT; Lieming, X; Martin, PY; Ohara, M; Olson, BR; Oren, RM; Schrier, RW1
Angers, S; Arthus, MF; Bernier, V; Bichet, DG; Bouvier, M; Laperrière, A; Lonergan, M; Morello, JP; Morin, D; Petäjä-Repo, U; Salahpour, A1
Thibonnier, M1
Pham, PC; Pham, PM; Pham, PT1
Verbalis, JG1
Omland, T; Solberg, OG1
Ali, F; Ghali, JK; Guglin, M; Vaitkevicius, P1
Balk, RA; Patel, GP1
Kumar, S; Mather, PJ; Rubin, S; Whellan, DJ1
Haskal, R1
Schweiger, TA; Zdanowicz, MM1
Farmakis, D; Filippatos, G; Gheorghiade, M; Kremastinos, DT1
Boerrigter, G; Burnett, JC; Costello-Boerrigter, LC1
Kumar, SK; Mather, PJ1
Goldsmith, SR1
Ghali, JK; Tam, SW1
Daifallah, S; Farah, JO; Ghali, JK; Zmily, HD1
Cantillo, DS; Comín Colet, J; Robledo, GG1
Daifallah, S; Ghali, JK; Khan, NS; Zmily, HD1
Iwao, H; Izumi, Y; Miura, K1

Reviews

19 review(s) available for lixivaptan and arginine vasopressin

ArticleYear
VPA-985, a nonpeptide orally active and selective vasopressin V2 receptor antagonist.
    Advances in experimental medicine and biology, 1998, Volume: 449

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Blood Pressure; Cyclic AMP; Dogs; Heart Failure; Humans; Hyponatremia; Inappropriate ADH Syndrome; Kidney; Pyrroles; Receptors, Vasopressin

1998
Vasopressin receptor antagonists in heart failure.
    Current opinion in pharmacology, 2003, Volume: 3, Issue:6

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Pyrroles; Randomized Controlled Trials as Topic; Tolvaptan

2003
Vasopressin excess and hyponatremia.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2006, Volume: 47, Issue:5

    Topics: Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Humans; Hyponatremia; Pyrroles; Receptors, Vasopressin; Tolvaptan; Water-Electrolyte Balance

2006
AVP receptor antagonists as aquaretics: review and assessment of clinical data.
    Cleveland Clinic journal of medicine, 2006, Volume: 73 Suppl 3

    Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Humans; Hyponatremia; Pyrroles; Receptors, Vasopressin; Tolvaptan; Water-Electrolyte Balance

2006
[Arginine vasopressin antagonism--new treatment option in chronic heart failure].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2007, Jan-18, Volume: 127, Issue:2

    Topics: Animals; Antidiuretic Agents; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Nephrons; Prognosis; Pyrroles; Receptors, Vasopressin; Tolvaptan; Treatment Outcome; Vasoconstrictor Agents

2007
Therapeutic potential of vasopressin receptor antagonists.
    Drugs, 2007, Volume: 67, Issue:6

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Hyponatremia; Inappropriate ADH Syndrome; Liver Cirrhosis; Morpholines; Pyrroles; Receptors, Vasopressin; Spiro Compounds; Tolvaptan

2007
Recognition and treatment of hyponatremia in acutely ill hospitalized patients.
    Clinical therapeutics, 2007, Volume: 29, Issue:2

    Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Critical Illness; Humans; Hyponatremia; Inpatients; Practice Guidelines as Topic; Pyrroles; Randomized Controlled Trials as Topic; Tolvaptan

2007
Hyponatremia and vasopressin antagonism in congestive heart failure.
    Clinical cardiology, 2007, Volume: 30, Issue:11

    Topics: Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Chronic Disease; Clinical Trials as Topic; Diuretics; Heart Failure; Humans; Hyponatremia; Models, Biological; Pyrroles; Registries; Renin-Angiotensin System; Sodium; Tolvaptan; Treatment Outcome; Vasopressins

2007
Current issues for nurse practitioners: Hyponatremia.
    Journal of the American Academy of Nurse Practitioners, 2007, Volume: 19, Issue:11

    Topics: Aged; Algorithms; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Causality; Decision Trees; Diagnosis, Differential; Early Diagnosis; Female; Homeostasis; Humans; Hyponatremia; Nurse Practitioners; Nurse's Role; Nursing Assessment; Patient Selection; Primary Health Care; Pyrroles; Tolvaptan; Water-Electrolyte Balance

2007
Vasopressin-receptor antagonists in heart failure.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2008, May-01, Volume: 65, Issue:9

    Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Cardiovascular Agents; Chronic Disease; Heart Failure; Humans; Hyponatremia; Pyrroles; Receptors, Vasopressin; Tolvaptan

2008
Vasopressin and vasopressin antagonists in heart failure and hyponatremia.
    Current heart failure reports, 2008, Volume: 5, Issue:2

    Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Heart Failure; Humans; Hyponatremia; Infusions, Intravenous; Male; Prognosis; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vasopressin; Risk Assessment; Survival Rate; Tolvaptan; Water-Electrolyte Imbalance

2008
Pharmacology of vasopressin antagonists.
    Heart failure reviews, 2009, Volume: 14, Issue:2

    Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Benzodiazepines; Heart Failure; Humans; Morpholines; Pyrroles; Receptors, Vasopressin; Spiro Compounds; Tolvaptan

2009
AVP receptor antagonists in patients with CHF.
    Heart failure reviews, 2009, Volume: 14, Issue:2

    Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Hyponatremia; Pyrroles; Receptors, Vasopressin; Sodium

2009
Treatment options for hyponatremia in heart failure.
    Heart failure reviews, 2009, Volume: 14, Issue:2

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Hyponatremia; Inappropriate ADH Syndrome; Pyrroles; Sodium Potassium Chloride Symporter Inhibitors; Tolvaptan; Treatment Outcome

2009
The critical link of hypervolemia and hyponatremia in heart failure and the potential role of arginine vasopressin antagonists.
    Journal of cardiac failure, 2010, Volume: 16, Issue:5

    Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Benzazepines; Blood Pressure; Blood Volume; Female; Heart Failure; Humans; Hypertension; Hyponatremia; Male; Prevalence; Prognosis; Pyrroles; Receptors, Vasopressin; Tolvaptan; United States; Water-Electrolyte Balance

2010
Lixivaptan, a non-peptide vasopressin V2 receptor antagonist for the potential oral treatment of hyponatremia.
    IDrugs : the investigational drugs journal, 2010, Volume: 13, Issue:11

    Topics: Administration, Oral; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Clinical Trials as Topic; Dogs; Heart Failure; Humans; Hyponatremia; Pyrroles; Rats

2010
[Hyponatremia in heart failure: physiopathology and pharmacological approach].
    Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2010, Volume: 57 Suppl 2

    Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Benzazepines; Body Water; Brain Edema; Demyelinating Diseases; Diuresis; Diuretics; Double-Blind Method; Heart Failure; Humans; Hyponatremia; Kidney; Multicenter Studies as Topic; Natriuresis; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vasopressin; Renin-Angiotensin System; Saline Solution, Hypertonic; Sympathetic Nervous System; Tolvaptan

2010
The potential role for lixivaptan in heart failure and in hyponatremia.
    Expert opinion on investigational drugs, 2011, Volume: 20, Issue:6

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Heart Failure; Humans; Hyponatremia; Plasma Volume; Pyrroles

2011
Therapeutic potential of vasopressin-receptor antagonists in heart failure.
    Journal of pharmacological sciences, 2014, Volume: 124, Issue:1

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Benzazepines; Body Water; Clinical Trials as Topic; Disease Models, Animal; Heart Failure; Homeostasis; Humans; Hyponatremia; Morpholines; Pyrroles; Receptors, Vasopressin; Spiro Compounds; Tolvaptan; Ventricular Remodeling

2014

Trials

2 trial(s) available for lixivaptan and arginine vasopressin

ArticleYear
5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]-[1, 4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985): an orally active arginine vasopressin antagonist with selectivity for V2 receptors.
    Journal of medicinal chemistry, 1998, Jul-02, Volume: 41, Issue:14

    Topics: Administration, Oral; Animals; Arginine Vasopressin; Azepines; Benzamides; Blood Platelets; Body Water; Cell Line; Cell Membrane; Dogs; Fibroblasts; Humans; Kidney; Liver; Osmolar Concentration; Pyrroles; Rats; Receptors, Vasopressin; Sodium; Structure-Activity Relationship; Urine

1998
Selective V2-receptor vasopressin antagonism decreases urinary aquaporin-2 excretion in patients with chronic heart failure.
    Journal of the American Society of Nephrology : JASN, 1999, Volume: 10, Issue:10

    Topics: Administration, Oral; Aged; Aquaporin 2; Aquaporin 6; Aquaporins; Arginine Vasopressin; Azepines; Benzamides; Biomarkers; Blotting, Western; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Failure; Humans; Male; Middle Aged; Pyrroles; Reference Values; Sensitivity and Specificity

1999

Other Studies

2 other study(ies) available for lixivaptan and arginine vasopressin

ArticleYear
Binding properties of a selective tritiated vasopressin V2 receptor antagonist, [H]-SR 121463.
    Kidney international, 2000, Volume: 58, Issue:4

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Binding, Competitive; Cattle; CHO Cells; Cricetinae; Dogs; Haplorhini; Homeostasis; Humans; Kidney; Kinetics; Morpholines; Rabbits; Radioligand Assay; Rats; Spiro Compounds; Swine; Tritium; Vasopressins; Water-Electrolyte Balance

2000
Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants.
    The Journal of clinical investigation, 2000, Volume: 105, Issue:7

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Cell Line; Cell Membrane; COS Cells; Diabetes Insipidus, Nephrogenic; Flow Cytometry; Humans; Intracellular Fluid; Molecular Chaperones; Morpholines; Mutagenesis; Protein Folding; Pyrroles; Receptors, Vasopressin; Spiro Compounds

2000