lithium-perchlorate and prolinol

lithium-perchlorate has been researched along with prolinol* in 2 studies

Other Studies

2 other study(ies) available for lithium-perchlorate and prolinol

Article	Year
Synthesis of Ribo-Azanucleosides by Anodic Oxidation: Reactivity Control of Intermediate for Efficient Access to Pharmacophores. Chemistry (Weinheim an der Bergstrasse, Germany), 2018, Dec-05, Volume: 24, Issue:68 Azanucleosides, the sugar-modified nucleoside analogues, have various biological activities, while their efficient synthetic strategy is still under development. Herein, a novel method for the synthesis of pharmaceutically relevant azanucleosides, β-anomers of ribo-azanucleosides, by means of site-specific anodic C-H activation by using a nitroalkane-lithium perchlorate medium is reported. A mechanistic study of the electrochemical reaction and the armed/disarmed concept from traditional glycochemistry revealed that the 2'-substituent has a significant effect on the reactivity of prolinol derivative, and suitable carboxylic acid additives can control the reactivity of the intermediate species, an iminium cation equivalent. Finally, this method was demonstrated to be applicable for the synthesis of β-anomers of ribo-azanucleosides with all four nucleobases in a stereoselective manner. Topics: Aza Compounds; Chemistry Techniques, Synthetic; Electrodes; Lithium Compounds; Nucleosides; Oxidation-Reduction; Perchlorates; Pyrrolidines; Stereoisomerism	2018
Electrochemical synthesis of azanucleoside derivatives using a lithium perchlorate-nitromethane system. Chemical communications (Cambridge, England), 2013, Jul-25, Volume: 49, Issue:58 We have developed a highly efficient synthetic method for azanucleosides using a lithium perchlorate-nitromethane reaction medium, allowing direct and exclusive installation of various nucleophiles, including protected nucleobases into prolinol derivatives at the preferred 5-position. Topics: Aza Compounds; Electrochemical Techniques; Lithium Compounds; Methane; Nitroparaffins; Nucleosides; Perchlorates; Pyrrolidines	2013

Article

Year

Synthesis of Ribo-Azanucleosides by Anodic Oxidation: Reactivity Control of Intermediate for Efficient Access to Pharmacophores.

Chemistry (Weinheim an der Bergstrasse, Germany), 2018, Dec-05, Volume: 24, Issue:68

Azanucleosides, the sugar-modified nucleoside analogues, have various biological activities, while their efficient synthetic strategy is still under development. Herein, a novel method for the synthesis of pharmaceutically relevant azanucleosides, β-anomers of ribo-azanucleosides, by means of site-specific anodic C-H activation by using a nitroalkane-lithium perchlorate medium is reported. A mechanistic study of the electrochemical reaction and the armed/disarmed concept from traditional glycochemistry revealed that the 2'-substituent has a significant effect on the reactivity of prolinol derivative, and suitable carboxylic acid additives can control the reactivity of the intermediate species, an iminium cation equivalent. Finally, this method was demonstrated to be applicable for the synthesis of β-anomers of ribo-azanucleosides with all four nucleobases in a stereoselective manner.

Topics: Aza Compounds; Chemistry Techniques, Synthetic; Electrodes; Lithium Compounds; Nucleosides; Oxidation-Reduction; Perchlorates; Pyrrolidines; Stereoisomerism

2018

Electrochemical synthesis of azanucleoside derivatives using a lithium perchlorate-nitromethane system.

Chemical communications (Cambridge, England), 2013, Jul-25, Volume: 49, Issue:58

We have developed a highly efficient synthetic method for azanucleosides using a lithium perchlorate-nitromethane reaction medium, allowing direct and exclusive installation of various nucleophiles, including protected nucleobases into prolinol derivatives at the preferred 5-position.

Topics: Aza Compounds; Electrochemical Techniques; Lithium Compounds; Methane; Nitroparaffins; Nucleosides; Perchlorates; Pyrrolidines

2013