lithium-chloride has been researched along with trimethobenzamide* in 2 studies
2 other study(ies) available for lithium-chloride and trimethobenzamide
| Article | Year |
|---|---|
Chin rub CRs may reflect conditioned sickness elicited by a lithium-paired sucrose solution.
Rats were given a single conditioning trial in which 20% sucrose solution was paired with an intraperitoneal (IP) injection of lithium chloride (127.2 mg/kg), d-amphetamine (3 mg/kg) or physiological saline. Thirty min before a subsequent 10-min taste reactivity (TR) test and a 1-h conditioned taste avoidance (CTA) test the rats were injected IP with either the antiemetic agent, trimethobenzamide (5 mg/kg) [corrected] or with physiological saline solution. The lithium-paired, but not the amphetamine- or saline-paired, sucrose solution elicited the aversive TR responses of chin rubs, paw pushes and gapes. Trimethobenzamide suppressed the aversive TR response of chin rubs in the lithium-conditioned group, but not in a group given unconditionally aversive quinine solution. The CTA test was not sensitive to the antiemetic properties of trimethobenzamide, although the drug enhanced sucrose preference overall. The results suggest that chin rub responses may measure conditioned sickness. Topics: Animals; Antiemetics; Benzamides; Chlorides; Conditioning, Psychological; Dextroamphetamine; Food Preferences; Lithium; Lithium Chloride; Male; Quinine; Rats; Rats, Inbred Strains; Solutions; Sucrose; Taste | 1991 |
Effects of antiemetics on the acquisition and recall of radiation- and lithium chloride-induced conditioned taste aversions.
A series of experiments were run to evaluate the effect of antiemetics on the acquisition and recall of a conditioned taste aversion induced by exposure to ionizing radiation or by injection of lithium chloride. Groups of male rats were exposed to 100 rad gamma radiation or 3 mEq/kg lithium chloride following consumption of a 10% sucrose solution. They were then injected with saline or with one of three antiemetics (prochlorperazine, trimethobenzamide, or cyclizine) at dose levels that have been reported to be effective in attenuating a previously acquired lithium chloride-induced taste aversion. The pretreatments with antiemetics had no effect on the acquisition or recall of either the lithium chloride- or radiation-induced taste aversion. The data suggest that antiemetics do not disrupt lithium chloride-induced taste aversions as previously reported, nor do they effect radiation-induced taste aversion learning. Topics: Animals; Antiemetics; Avoidance Learning; Benzamides; Chlorides; Cyclizine; Lithium; Lithium Chloride; Male; Prochlorperazine; Rats; Rats, Inbred Strains; Taste | 1983 |