lithium-chloride has been researched along with tetrahydrofuran* in 4 studies
4 other study(ies) available for lithium-chloride and tetrahydrofuran
| Article | Year |
|---|---|
MeLi + LiCl in THF: one heterodimer and no tetramers.
The structure of the aggregates formed when mixing methyllithium and lithium chloride in THF has been studied by multinuclear magnetic resonance at 170 K. The data suggest that only one new entity is observed, that is the dimer [(MeLi)(LiCl)], in equilibrium (K approximately 0.6) with [MeLi](4) and [LiCl](2). NMR diffusion measurements lead to the conclusion that this dimer is trisolvated in THF at 170 K, a solvation scheme in agreement with DFT computations. Topics: Computer Simulation; Dimerization; Furans; Lithium Chloride; Magnetics; Molecular Structure; Organometallic Compounds | 2010 |
1,4-addition of lithium diisopropylamide to unsaturated esters: role of rate-limiting deaggregation, autocatalysis, lithium chloride catalysis, and other mixed aggregation effects.
Lithium diisopropylamide (LDA) in tetrahydrofuran at -78 °C undergoes 1,4-addition to an unsaturated ester via a rate-limiting deaggregation of LDA dimer followed by a post-rate-limiting reaction with the substrate. Muted autocatalysis is traced to a lithium enolate-mediated deaggregation of the LDA dimer and the intervention of LDA-lithium enolate mixed aggregates displaying higher reactivities than LDA. Striking accelerations are elicited by <1.0 mol % LiCl. Rate and mechanistic studies have revealed that the uncatalyzed and catalyzed pathways funnel through a common monosolvated-monomer-based intermediate. Four distinct classes of mixed aggregation effects are discussed. Topics: Catalysis; Esters; Furans; Kinetics; Lithium; Lithium Chloride; Molecular Structure; Propylamines | 2010 |
The Morita-Baylis-Hillman adducts of beta-aryl nitroethylenes with other activated alkenes: synthesis and anticancer activity studies.
The Morita-Baylis-Hillman (MBH) adducts of beta-aryl nitroethylenes with methyl vinyl ketone (MVK) and acrylate, formed in moderate to good yield when mediated by imidazole/LiCl in THF at room temperature, inhibit HeLa cell proliferation by binding to tubulin. Topics: Acrylates; Alkenes; Antineoplastic Agents; Binding Sites; Butanones; Cell Proliferation; Ethylenes; Furans; HeLa Cells; Humans; Imidazoles; Lithium Chloride; Models, Chemical; Nitro Compounds; Temperature; Tubulin | 2006 |
Complexation and medium effects on the conformation of cyclosporin A studied by NMR spectroscopy and molecular dynamics calculations.
The conformation of cyclosporin A was investigated in different environments. Whereas there was no distinct difference between the structure of CSA in CDCl3 and THF, the addition of LiCl caused a conformational change. Also, using polar solvents (DMSO, water) induced conformational changes in the backbone as well as the side chains. Topics: Benzene; Chlorides; Chloroform; Cyclosporins; Deuterium; Furans; Lithium; Lithium Chloride; Magnetic Resonance Spectroscopy; Protein Conformation | 1990 |