lithium-chloride has been researched along with glucose-1-phosphate* in 1 studies
1 other study(ies) available for lithium-chloride and glucose-1-phosphate
| Article | Year |
|---|---|
Lithium induces phosphoglucomutase activity in various tissues of rats and in bipolar patients.
Phosphoglucomutase catalyses the reversible conversion of glucose-6-P and glucose-1-P. Lithium is a potent inhibitor of phosphoglucomutase in vitro, however, it is not known if phosphoglucomutase was significantly inhibited by Li+ in Li+-treated bipolar patients. Here, we demonstrate that phosphoglucomutase inhibition by chronic Li+ treatment causes alterations of glucose-phosphate levels in various tissues of rats. Also, phosphoglucomutase inhibition results in compensatory elevation of phosphoglucomutase activity in rat tissues and in leukocytes isolated from Li+-treated bipolar patients. The increase of uninhibited phosphoglucomutase activity in leukocytes of Li+-treated bipolar patients is due to the increased expression of the PGM1 gene. Topics: Animals; Antimanic Agents; Bipolar Disorder; Brain; Calcium; Glucose-6-Phosphate; Glucosephosphates; Humans; Leukocytes; Lithium Chloride; Liver; Magnesium; Male; Muscle, Skeletal; Myocardium; Phosphoglucomutase; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2006 |