lithium-chloride and acetylcellulose

The effect of cellulose acetate (CA)/polyethyleneoxide (PEO) ratio (0.5-1.5 wt%) and lithium chloride (LiCl) content (0.25-0.75%, w/v) on the viscosity, surface tension and electrical conductivity (EC) of the solutions and diameter of the fabricated nanofiber membranes (NFMs) were optimized using response surface methodology-central composite rotatable design (RSM-CCRD). The NFMs were composed of non-woven fibers with maximum diameter of 121.70 ± 33.40. Second-order polynomial models with high R(2) values (0.977-0.998) were developed using multiple linear regression analysis. Results showed that the NFMs diameter and morphology were significantly affected by CA and LiCl contents (p<0.0001). The overall optimum region was found to be at the combined level of CA to PEO ratio of 1.5 wt% and LiCl content of 0.5% (w/v). At the optimum point, the viscosity, surface tension, EC and diameter were 0.425 ± 0.036 Pas, 36.21 ± 1.25 mN/m, 0.383 ± 0.014 ms/cm, and 82.19 ± 3.01 nm, respectively. The most uniform and bead-free NFMs were fabricated from the solution formulated with 1 wt% CA/PEO and 0.85% (w/v) of LiCl content.

Topics: Cellulose; Chemistry, Pharmaceutical; Electric Conductivity; Lithium Chloride; Nanofibers; Polyethylene Glycols; Solutions; Surface Tension; Viscosity