Compounds > lithium-bis(trimethylsilyl)amide

lithium-bis(trimethylsilyl)amide and benzimidazole

lithium-bis(trimethylsilyl)amide has been researched along with benzimidazole* in 1 studies

Other Studies

1 other study(ies) available for lithium-bis(trimethylsilyl)amide and benzimidazole

Article	Year
Lithium Hexamethyldisilazane Transformation of Transiently Protected 4-Aza/Benzimidazole Nitriles to Amidines and their Dimethyl Sulfoxide Mediated Imidazole Ring Formation. Organic letters, 2016, 09-16, Volume: 18, Issue:18 Trimethylsilyl-transient protection successfully allowed the use of lithium hexamethyldisilazane to prepare benzimidazole (BI) and 4-azabenzimidazole (azaBI) amidines from nitriles in 58-88% yields. This strategy offers a much better choice to prepare BI/azaBI amidines than the lengthy, low-yielding Pinner reaction. Synthesis of aza/benzimidazole rings from aromatic diamines and aldehydes was affected in dimethyl sulfoxide in 10-15 min, while known procedures require long time and purification. These methods are important for the BI/azaBI-based drug industry and for developing specific DNA binders for expanded therapeutic applications. Topics: Amidines; Aza Compounds; Benzimidazoles; Dimethyl Sulfoxide; Imidazoles; Lithium Compounds; Molecular Structure; Nitriles; Silanes	2016

Article

Year

Lithium Hexamethyldisilazane Transformation of Transiently Protected 4-Aza/Benzimidazole Nitriles to Amidines and their Dimethyl Sulfoxide Mediated Imidazole Ring Formation.

Organic letters, 2016, 09-16, Volume: 18, Issue:18

Trimethylsilyl-transient protection successfully allowed the use of lithium hexamethyldisilazane to prepare benzimidazole (BI) and 4-azabenzimidazole (azaBI) amidines from nitriles in 58-88% yields. This strategy offers a much better choice to prepare BI/azaBI amidines than the lengthy, low-yielding Pinner reaction. Synthesis of aza/benzimidazole rings from aromatic diamines and aldehydes was affected in dimethyl sulfoxide in 10-15 min, while known procedures require long time and purification. These methods are important for the BI/azaBI-based drug industry and for developing specific DNA binders for expanded therapeutic applications.

Topics: Amidines; Aza Compounds; Benzimidazoles; Dimethyl Sulfoxide; Imidazoles; Lithium Compounds; Molecular Structure; Nitriles; Silanes

2016