lithium has been researched along with piperidines in 64 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 21 (32.81) | 18.7374 |
1990's | 9 (14.06) | 18.2507 |
2000's | 20 (31.25) | 29.6817 |
2010's | 14 (21.88) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Denber, HC | 1 |
Lassen, JB; Squires, RF | 1 |
Gol'dovskaia, IL | 1 |
Ida, S; Natsuki, R; Oguri, K; Yoshimura, H | 1 |
Jørgensen, OS; Mellerup, ET; Plenge, P | 1 |
Ben-Zeev, A; Lerer, B; Newman, ME | 1 |
Haffmans, PM; Hoencamp, E | 1 |
Amery, A; Fagard, R; Fiocchi, R; Lijnen, P; M'Buyamba-Kabangu, JR; Staessen, J | 1 |
Buus Lassen, J | 1 |
Ambrose, BJ; Ayers, ME; Pless, RC | 1 |
Olney, JW | 1 |
Banay-Schwartz, M; Lajtha, A; Manigault, I; Wajda, IJ | 1 |
Collins, RC; Olney, JW; Sloviter, RS | 1 |
Hayakawa, H; Maruyama, Y; Miyasaka, T; Obi, K; Tanaka, H | 1 |
Vinar, O | 1 |
Kitatsuji, E | 1 |
Lausen, HH; Roth, HJ | 1 |
Dugas, M; Frohwirth, C; Guériot, C; Velin, J | 1 |
Böhme, H; Dehmel, H | 2 |
Boey, J; Hermans, B; Janssen, PA; Van Daele, P; Van de Westeringh, C; Van der Eycken, C | 2 |
Battaglia, G; Shannon, M; Titeler, M | 1 |
Alexander, JW; Gonce, SJ; Loose, LD; Miskell, P; Stinnett, JD; Tenney, CL | 1 |
Azorin, JM | 1 |
Fras, I; Major, LF | 1 |
Dijken, WA; Duivenvoorden, H; Haffmans, PM; Hoencamp, E; Knegtering, H | 1 |
Dijken, WA; Haffmans, PM; Hoencamp, E; Hoogduin, CA; Nolen, WA; van Dyck, R | 1 |
Bourin, M; Redrobe, JP | 1 |
Alfieri, AB; Cubeddu, LX | 1 |
Chambournier, G; Gawley, RE; Low, E | 1 |
Chambournier, G; Gawley, RE | 1 |
Bailey, WF; Beak, P; Kerrick, ST; Ma, S; Wiberg, KB | 1 |
Kozlowski, MC; Xu, Z | 1 |
Beak, P; Curtis, MD; Jang, DO; Johnson, TA; Slafer, BW | 1 |
Abbott, L; Burton, P; Fudge, ML; Mechoulam, R; Parker, LA; Schlievert, C | 1 |
Chambournier, G; Gawley, RE; Low, E; Santiago, M | 1 |
Collum, DB; Ramírez, A; Wiedemann, SH | 1 |
Burton, P; Kwiatkowska, M; Mechoulam, R; Parker, LA | 1 |
Tomioka, K; Yamada, K; Yamashita, M | 1 |
Atobe, M; Kibayashi, C; Yamazaki, N | 1 |
Davies, SG; Díez, D; Dominguez, SH; Garrido, NM; Kruchinin, D; Price, PD; Smith, AD | 1 |
Cecchin, F; Husson, HP; Roulland, E | 1 |
Furuyama, T; Matsumoto, Y; Morokuma, K; Nobuto, D; Uchiyama, M; Yamaguchi, K | 1 |
Adsool, VA; Pansare, SV | 1 |
Hashimoto, Y; Matsumoto, Y; Morokuma, K; Uchiyama, M; Usui, S | 1 |
Barratt, ML; Smith, K | 1 |
Davies, SG; Roberts, PM; Smith, AD | 1 |
Coldham, I; Patel, JJ; Raimbault, S; Whittaker, DT | 1 |
Abraham, E; Brock, EA; Candela-Lena, JI; Davies, SG; Georgiou, M; Nicholson, RL; Perkins, JH; Roberts, PM; Russell, AJ; Sánchez-Fernández, EM; Scott, PM; Smith, AD; Thomson, JE | 1 |
Beng, TK; Gawley, RE | 1 |
Barker, G; Campos, KR; Coldham, I; Firth, JD; Leonori, D; Meijer, AJ; O'Brien, P; Sheikh, NS | 1 |
Beng, TK; Gawley, RE; Woo, JS | 1 |
Harada, S; Sakai, T; Takasu, K; Tomioka, K; Yamada, K; Yamamoto, Y | 1 |
Beng, TK; Gawley, RE; Parker, T; Su, C; Tyree, WS; Williard, PG | 1 |
Ford, MJ; Knochel, P; Unsinn, A | 1 |
Chevallier, F; Gros, PC; Halauko, YS; Ivashkevich, OA; Kadiyala, RR; Matulis, VE; Mongin, F; Nagaradja, E; Roisnel, T; Tilly, D | 1 |
Armstrong, DR; Garden, JA; Kennedy, AR; Leenhouts, SM; Mulvey, RE; O'Hara, CT; O'Keefe, P; Steven, A | 1 |
Haas, D; Knochel, P; Mosrin, M | 1 |
El-Shentenawy, A; Mohammed, AA | 1 |
Butterworth, S; Clayden, J; Tait, MB | 1 |
Beng, TK; Sarpong, R; Takeuchi, H; Weber, M | 1 |
Atobe, M; Bond, PS; Fairlamb, IJ; Haji-Cheteh, C; Hubbard, RE; Lüthy, M; O'Brien, P; Wheldon, MC | 1 |
Asth, L; Calo', G; Gavioli, EC; Guerrini, R; Ruzza, C; Silva, AI; Silva, EF; Souza, LS; Zaveri, NT | 1 |
5 review(s) available for lithium and piperidines
Article | Year |
---|---|
[Psychotropic therapy and intraocular pressure].
Topics: Amitriptyline; Analgesics; Antidepressive Agents; Chlorpromazine; Diazepam; Diphenhydramine; Eye Diseases; Glaucoma; Histamine H1 Antagonists; Humans; Imipramine; Intraocular Pressure; Lithium; Mental Disorders; Mephenesin; Meprobamate; Piperidines; Psychotropic Drugs; Secologanin Tryptamine Alkaloids; Tranquilizing Agents; Trihexyphenidyl | 1975 |
Excitatory transmitters and epilepsy-related brain damage.
Topics: Acetylcholine; Amygdala; Animals; Brain; Cholinesterase Inhibitors; Convulsants; Electric Stimulation; Epilepsy; Kainic Acid; Lithium; Nerve Degeneration; Neural Pathways; Neurons; Neurotransmitter Agents; Piperidines; Rats; Somatosensory Cortex; Synaptic Transmission | 1985 |
[Psychopharmaca in modern medicine].
Topics: Amphetamine; Antidepressive Agents; Barbiturates; Butyrophenones; Chlordiazepoxide; Chlorprothixene; Diazepam; Dibenzazepines; Guaifenesin; Hallucinogens; Humans; Hypnotics and Sedatives; Imipramine; Lithium; Lysergic Acid Diethylamide; Methylphenidate; Monoamine Oxidase Inhibitors; Oxazepam; Phenmetrazine; Phenothiazines; Phytotherapy; Piperidines; Plants, Medicinal; Psilocybin; Psychopharmacology; Rauwolfia; Reserpine; Tranquilizing Agents; Xanthenes | 1968 |
Long-term treatment of mood disorders in schizophrenia.
Topics: Affective Symptoms; Antidepressive Agents; Antipsychotic Agents; Clozapine; Drug Therapy, Combination; Humans; Isoxazoles; Lithium; Long-Term Care; Piperidines; Psychiatric Status Rating Scales; Risperidone; Schizophrenia; Schizophrenic Psychology | 1995 |
Advanced thyroid cancers: new era of treatment.
Topics: Anilides; Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Differentiation; Cell Proliferation; ErbB Receptors; Genetic Therapy; Histone Deacetylase Inhibitors; Humans; Immunotherapy; Lithium; Molecular Targeted Therapy; Piperidines; Protein Kinase Inhibitors; Pyrazines; Pyridines; Quinazolines; Stilbenes; Thalidomide; Thyroid Neoplasms | 2014 |
2 trial(s) available for lithium and piperidines
Article | Year |
---|---|
Predictors of (non-) response in depressed outpatients treated with a three-phase sequential medication strategy.
Topics: Adult; Antidepressive Agents; Cross-Over Studies; Depressive Disorder; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Lithium; Male; Maprotiline; Middle Aged; Monoamine Oxidase Inhibitors; Personality Assessment; Personality Inventory; Piperidines; Treatment Outcome | 1994 |
Brofaromine versus lithium addition to maprotiline. A double-blind study in maprotiline refractory depressed outpatients.
Topics: Adolescent; Adult; Aged; Depressive Disorder; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Lithium; Male; Maprotiline; Middle Aged; Monoamine Oxidase Inhibitors; Personality Inventory; Piperidines; Prospective Studies; Recurrence | 1994 |
57 other study(ies) available for lithium and piperidines
Article | Year |
---|---|
The pharmacologic treatment of depression.
Topics: Amphetamine; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Deanol; Depression; Dose-Response Relationship, Drug; Humans; Lithium; Methylphenidate; Monoamine Oxidase Inhibitors; Phenmetrazine; Piperidines | 1979 |
Potentiation of nialamide-induced hypermotility in mice by lithium and the 5-HT uptake inhibitors chlorimipramine and FG 4963.
Topics: Animals; Anisoles; Clomipramine; Dibenzazepines; Dose-Response Relationship, Drug; Drug Synergism; Female; Fenclonine; Lithium; Mice; Mice, Inbred Strains; Motor Activity; Nialamide; Piperidines; Serotonin; Stimulation, Chemical; Time Factors; Tryptophan | 1976 |
Chemical reactivity of morphine and morphine-6-conjugates and their binding to rat brain.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; Glucuronates; In Vitro Techniques; Lithium; Liver; Male; Morphine; Morphine Derivatives; Piperidines; Protein Binding; Rats; Serum Albumin, Bovine | 1976 |
Lithium treatment regimens induce different changes in [3H]paroxetine binding protein and other rat brain proteins.
Topics: Animals; Brain Chemistry; Immunochemistry; Lithium; Male; Nerve Tissue Proteins; Paroxetine; Piperidines; Protein Binding; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1992 |
Chloroamphetamine did not prevent the effects of chronic antidepressants on 5-hydroxytryptamine inhibition of forskolin-stimulated adenylate cyclase in rat hippocampus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Antidepressive Agents; Binding Sites; Cerebral Cortex; Chlorides; Colforsin; Hippocampus; Imipramine; Lithium; Lithium Chloride; Male; p-Chloroamphetamine; Paroxetine; Piperidines; Rats; Serotonin; Synapses; Tetrahydronaphthalenes | 1991 |
Brofaromine vs. maprotiline plus lithium in treatment-resistant depressed outpatients.
Topics: Depressive Disorder; Drug Therapy, Combination; Humans; Lithium; Maprotiline; Monoamine Oxidase Inhibitors; Pilot Projects; Piperidines; Psychiatric Status Rating Scales | 1991 |
Effects of ketanserin on the intracellular concentration and transmembrane fluxes of sodium and potassium in erythrocytes of normal male subjects.
Topics: Cell Membrane Permeability; Erythrocyte Membrane; Erythrocytes; Furosemide; Humans; Ketanserin; Lithium; Male; Ouabain; Piperidines; Potassium; Serotonin Antagonists; Sodium | 1985 |
Nialamide-induced hypermotility in mice treated with inhibitors of monoamine uptake, 5-HT antagonists and lithium.
Topics: Animals; Diet; Female; Lithium; Mice; Monoamine Oxidase Inhibitors; Motor Activity; Nialamide; Paroxetine; Piperidines; Serotonin Antagonists | 1989 |
Sequence analysis of end-labeled DNA fragments by solvolysis in hot aqueous piperidine solutions.
Topics: Autoradiography; Base Sequence; Chlorides; DNA; Hot Temperature; Hydrolysis; Lithium; Lithium Chloride; Piperidines; Sodium Chloride | 1988 |
Modulation of the serotonin S2-receptor in brain after chronic lithium.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Domperidone; Ketanserin; Kinetics; Lithium; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin | 1986 |
Excitotoxic mechanisms of epileptic brain damage.
Topics: Administration, Topical; Amygdala; Animals; Axons; Biomechanical Phenomena; Brain; Choline; Cholinesterase Inhibitors; Convulsants; Corpus Striatum; Epilepsy; Folic Acid; Injections; Kainic Acid; Lithium; Motor Cortex; Neural Pathways; Neurotoxins; Piperidines; Rats; Seizures; Somatosensory Cortex | 1986 |
On the mechanism of lithiation of uridine derivatives with lithium dialkylamides.
Topics: Amides; Chemical Phenomena; Chemistry; Lithium; Piperidines; Structure-Activity Relationship; Uridine | 1985 |
[Reductive ring cleavage of piperidinium salts with lithium-diphenyl adduct].
Topics: Biphenyl Compounds; Chemical Phenomena; Chemistry; Lithium; Oxidation-Reduction; Piperidines; Spectrum Analysis | 1972 |
[Reduction of 1-piperidinomethyl-isatine with hydrides (author's transl)].
Topics: Aluminum; Borohydrides; Indoles; Lithium; Oxidation-Reduction; Piperidines | 1973 |
[Use of new drug treatments in child psychiatry (long-acting neuroleptics, antidepressive agents and lithium)].
Topics: Adolescent; Adult; Antidepressive Agents; Child; Child, Preschool; Delayed-Action Preparations; Dibenzazepines; Fluphenazine; Humans; Lithium; Mental Disorders; Piperidines; Sulfonamides; Tranquilizing Agents | 1973 |
[Chlorination of N-acetyl-piperidine. 15. N-alpha halogen alkyl-carbonic acid amide].
Topics: Acetates; Aluminum; Chemical Phenomena; Chemistry; Chlorine; Chromates; Deuterium; Lithium; Oxidation-Reduction; Piperidines; Spectrum Analysis | 1971 |
[Chlorination of various N-acetyl-piperidines. 18. N-alpha-halogen-alkyl-carbonic acid amide].
Topics: Aluminum; Amines; Chemical Phenomena; Chemistry; Chlorine; Deuterium; Lithium; Oxidation-Reduction; Piperidines | 1971 |
4-substituted piperidines. II. Reaction of 1-benzyl-4-cyano-4-t-aminopiperidines with organometallic compounds.
Topics: Animals; Cats; Chemical Phenomena; Chemistry; Cyanides; Heterocyclic Compounds; Hypnotics and Sedatives; Ketones; Lithium; Magnesium; Piperidines; Tranquilizing Agents | 1965 |
4-Substituted piperidines. 3. Reduction of 1-benzyl-4-cyano-4-r-aminopiperidines with lithium albuminium hydride.
Topics: Aluminum; Amines; Animals; Blood Pressure; Central Nervous System; Chemical Phenomena; Chemistry; Dogs; Indicators and Reagents; Lithium; Oxidation-Reduction; Piperidines | 1966 |
Modulation of brain S2 serotonin receptors by lithium, sodium and potassium chloride.
Topics: Animals; Binding, Competitive; Brain; Chlorides; Dose-Response Relationship, Drug; Female; Ketanserin; Lithium; Lithium Chloride; Piperidines; Potassium Chloride; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Sodium Chloride | 1983 |
Synthetic immunomodulators for prevention of fatal infections in a burned guinea pig model.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Burns; Diamines; Evaluation Studies as Topic; Female; Guinea Pigs; Lethal Dose 50; Levamisole; Lithium; Peptide Fragments; Piperidines; Pseudomonas aeruginosa; Pseudomonas Infections; Thymopentin; Thymopoietins; Time Factors | 1983 |
Clinical experience with risperidone.
Topics: Adolescent; Aggression; Antipsychotic Agents; Bipolar Disorder; Child; Child Behavior Disorders; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Isoxazoles; Lithium; Male; Piperidines; Risperidone | 1995 |
Evidence of the activity of lithium on 5-HT1B receptors in the mouse forced swimming test: comparison with carbamazepine and sodium valproate.
Topics: Animals; Antimanic Agents; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Lithium; Mice; Motor Activity; Piperidines; Pyridines; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Serotonin Receptor Agonists; Swimming; Valproic Acid | 1999 |
Role of NK1 receptors on cisplatin-induced nephrotoxicity in the rat.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Cisplatin; Creatinine; Drug Interactions; Kidney; Lithium; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Tetrazoles | 2000 |
Unusual conformational effect in alpha-aminoorganostannanes.
Topics: Lithium; Magnetic Resonance Spectroscopy; Molecular Conformation; Organotin Compounds; Piperidines | 1999 |
Synthesis and reactivity of conformationally locked alpha-aminoorganostannanes and alpha-aminoorganolithiums. Discovery of a surprising configurational requirement for transmetalation.
Topics: Lithium; Molecular Conformation; Organometallic Compounds; Organotin Compounds; Piperidines | 2000 |
An experimental and computational investigation of the enantioselective deprotonation of Boc-piperidine.
Topics: Lithium; Models, Molecular; Organometallic Compounds; Piperidines; Protons; Sparteine; Stereoisomerism; Thermodynamics | 2002 |
Conformational control of flexible molecules: design and synthesis of novel chiral 1,5-diaza-cis-decalins.
Topics: Aza Compounds; Catalysis; Heterocyclic Compounds, 2-Ring; Ligands; Lithium; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Conformation; Molecular Structure; Piperidines; Pyrrolidines; Sparteine; Stereoisomerism; Structure-Activity Relationship | 2002 |
Asymmetric carbon-carbon bond formations in conjugate additions of lithiated N-Boc allylic and benzylic amines to nitroalkenes: enantioselective synthesis of substituted piperidines, pyrrolidines, and pyrimidinones.
Topics: Alkenes; Amines; Benzylamines; Formic Acid Esters; Lithium; Nitro Compounds; Organometallic Compounds; Piperidines; Pyrimidinones; Pyrrolidines; Stereoisomerism | 2002 |
Effects of cannabinoids on lithium-induced conditioned rejection reactions in a rat model of nausea.
Topics: Animals; Antiemetics; Avoidance Learning; Behavior, Animal; Cannabinoids; Conditioning, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Lithium; Male; Nausea; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 2003 |
Modeling and experiment reveal an unexpected stereoelectronic effect on conformation and scalar couplings of alpha-aminoorganostannanes, with possible relevance to the tin-lithium exchange reaction.
Topics: Carbon Isotopes; Lithium; Models, Chemical; Molecular Conformation; Nitrogen; Nitrogen Isotopes; Organotin Compounds; Piperidines; Tin; Trialkyltin Compounds | 2003 |
Lithium 2,2,6,6-tetramethylpiperidide-mediated alpha- and beta-lithiations of epoxides: solvent-dependent mechanisms.
Topics: Epoxy Compounds; Kinetics; Lithium; Models, Molecular; Organometallic Compounds; Piperidines; Solvents; Thermodynamics | 2003 |
A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew).
Topics: Animals; Antiemetics; Antineoplastic Agents; Cannabinoids; Cisplatin; Dose-Response Relationship, Drug; Dronabinol; Drug Therapy, Combination; Female; Lithium; Male; Ondansetron; Piperidines; Psychotropic Drugs; Pyrazoles; Rimonabant; Shrews; Vomiting | 2004 |
Construction of arene-fused-piperidine motifs by asymmetric addition of 2-trityloxymethylaryllithiums to nitroalkenes: the asymmetric synthesis of a dopamine D1 full agonist, A-86929.
Topics: Alkenes; Dopamine Agonists; Lithium; Nitro Compounds; Organometallic Compounds; Piperidines; Quinolones; Receptors, Dopamine D1; Stereoisomerism; Thiophenes | 2004 |
Enantioselective synthesis of primary 1-(aryl)alkylamines by nucleophilic 1,2-addition of organolithium reagents to hydroxyoxime ethers and application to asymmetric synthesis of G-protein-coupled receptor ligands.
Topics: Amines; Aniline Compounds; Calcium; Ethers; Ligands; Lithium; Molecular Mimicry; Molecular Structure; Neurokinin-1 Receptor Antagonists; Organometallic Compounds; Phenethylamines; Piperidines; Propylamines; Receptors, G-Protein-Coupled; Stereoisomerism | 2004 |
Cyclic beta-amino acid derivatives: synthesis via lithium amide promoted tandem asymmetric conjugate addition-cyclisation reactions.
Topics: Amides; Amino Acids, Cyclic; Cyclization; Lithium; Magnetic Resonance Spectroscopy; Mass Spectrometry; Optical Rotation; Piperidines; Spectrophotometry, Infrared | 2005 |
Diasteroselective synthesis of new spiropiperidine scaffolds from the CN(R,S) building block.
Topics: Alkaloids; Chemistry, Organic; Lithium; Molecular Mimicry; Molecular Structure; Nitriles; Piperidines; Stereoisomerism; Thermodynamics | 2005 |
Structure and reaction pathway of TMP-Zincate: amido base or alkyl base?
Topics: Crystallography, X-Ray; Lithium; Models, Chemical; Models, Molecular; Organometallic Compounds; Piperidines; Zinc | 2006 |
Enantioselective synthesis of functionalized medium-sized oxacycles.
Topics: Cyclization; Electrons; Heterocyclic Compounds, 1-Ring; Indicators and Reagents; Lactams; Lithium; Methylation; Niacin; Niacinamide; Piperidines; Pyridines | 2006 |
Origin of chemoselectivity of TMP zincate bases and differences between TMP zincate and alkyl lithium reagents: a DFT study on model systems.
Topics: Lithium; Models, Chemical; Molecular Structure; Organometallic Compounds; Piperidines; Quantum Theory; Zinc | 2007 |
Highly selective 5-substitution of 3-methylthiophene via directed lithiation.
Topics: Lithium; Methylation; Models, Chemical; Organometallic Compounds; Piperidines; Thiophenes | 2007 |
Asymmetric three- and [2 + 1]-component conjugate addition reactions for the stereoselective synthesis of polysubstituted piperidinones.
Topics: Crystallography, X-Ray; Esters; Lithium; Oxazolidinones; Piperidines; Piperidones; Stereoisomerism; Temperature | 2007 |
Dynamic kinetic and kinetic resolution of N-Boc-2-lithiopiperidine.
Topics: Kinetics; Lithium; Organometallic Compounds; Piperidines; Stereoisomerism | 2007 |
Asymmetric synthesis of N,O,O,O-tetra-acetyl d-lyxo-phytosphingosine, jaspine B (pachastrissamine), 2-epi-jaspine B, and deoxoprosophylline via lithium amide conjugate addition.
Topics: Amides; Benzylamines; Lithium; Molecular Conformation; Organometallic Compounds; Oxidation-Reduction; Piperidines; Sphingosine; Stereoisomerism | 2008 |
Highly enantioselective catalytic dynamic resolution of N-Boc-2-lithiopiperidine: synthesis of (R)-(+)-N-Boc-pipecolic acid, (S)-(-)-coniine, (S)-(+)-pelletierine, (+)-beta-conhydrine, and (S)-(-)-ropivacaine and formal synthesis of (-)-lasubine II and (+
Topics: Alkaloids; Amides; Catalysis; Heterocyclic Compounds, 2-Ring; Lithium; Molecular Conformation; Organometallic Compounds; Pipecolic Acids; Piperidines; Quinolizines; Ropivacaine; Stereoisomerism; Thermodynamics | 2010 |
An experimental and in situ IR spectroscopic study of the lithiation-substitution of N-Boc-2-phenylpyrrolidine and -piperidine: controlling the formation of quaternary stereocenters.
Topics: Lithium; Molecular Structure; Organometallic Compounds; Piperidines; Pyrrolidines; Quantum Theory; Spectrophotometry, Infrared; Stereoisomerism | 2012 |
Synthetic applications and inversion dynamics of configurationally stable 2-lithio-2-arylpyrrolidines and -piperidines.
Topics: Lithium; Molecular Conformation; Organometallic Compounds; Piperidines; Pyrrolidines; Stereoisomerism; Thermodynamics | 2012 |
Total synthesis of (-)-kopsinine by an asymmetric one-pot [n+2+3] cyclization.
Topics: Alkylation; Amides; Cyclization; Indole Alkaloids; Lithium; Piperidines; Stereoisomerism | 2012 |
Dynamics of catalytic resolution of 2-lithio-N-Boc-piperidine by ligand exchange.
Topics: Catalysis; Crystallography, X-Ray; Ethylenediamines; Ligands; Lithium; Magnetic Resonance Spectroscopy; Models, Molecular; Piperidines; Stereoisomerism | 2012 |
New preparation of TMPZnCl·LiCl by Zn insertion into TMPCl. Application to the functionalization of dibromodiazines.
Topics: Combinatorial Chemistry Techniques; Hydrocarbons, Chlorinated; Lithium; Molecular Structure; Organometallic Compounds; Piperidines; Pyridazines; Stereoisomerism; Zinc | 2013 |
Computed CH acidity of biaryl compounds and their deprotonative metalation by using a mixed lithium/zinc-TMP base.
Topics: Amides; Catalysis; Combinatorial Chemistry Techniques; Heterocyclic Compounds; Hydrocarbons, Iodinated; Kinetics; Lithium; Models, Chemical; Molecular Structure; Palladium; Piperidines; Zinc | 2013 |
Evaluating cis-2,6-dimethylpiperidide (cis-DMP) as a base component in lithium-mediated zincation chemistry.
Topics: Crystallography, X-Ray; Lithium; Magnetic Resonance Spectroscopy; Molecular Structure; Organometallic Compounds; Piperidines; Quantum Theory; Zinc | 2013 |
Regioselective functionalization of the oxazole scaffold using TMP-bases of Mg and Zn.
Topics: Lithium; Magnesium; Molecular Structure; Organometallic Compounds; Oxazoles; Piperidines; Stereoisomerism; Zinc | 2013 |
2,2- and 2,6-Diarylpiperidines by aryl migration within lithiated urea derivatives of tetrahydropyridines.
Topics: Cyclization; Lithium; Molecular Structure; Piperidines; Pyridines; Pyrroles; Urea | 2015 |
Stereocontrolled synthesis of vicinally functionalized piperidines by nucleophilic β-addition of alkyllithiums to α-aryl substituted piperidine enecarbamates.
Topics: Carbamates; Lithium; Molecular Structure; Organometallic Compounds; Piperidines; Quantum Theory; Stereoisomerism | 2015 |
Lead-oriented synthesis: Investigation of organolithium-mediated routes to 3-D scaffolds and 3-D shape analysis of a virtual lead-like library.
Topics: Combinatorial Chemistry Techniques; Drug Discovery; Heterocyclic Compounds; Lithium; Molecular Structure; Organometallic Compounds; Piperazine; Piperazines; Piperidines; Pyrrolidines; Small Molecule Libraries | 2015 |
Nociceptin/orphanin FQ receptor agonists increase aggressiveness in the mouse resident-intruder test.
Topics: Aggression; Agonistic Behavior; Animals; Anxiety; Bipolar Disorder; Carbamazepine; Cycloheptanes; Depression; Depressive Disorder; Disease Models, Animal; Fenclonine; Lithium; Male; Mice; Mice, Knockout; Nociceptin; Nociceptin Receptor; Opioid Peptides; Piperidines; Receptors, Opioid; Valproic Acid | 2019 |