lipoteichoic-acid and 1-3-4-oxadiazole

lipoteichoic-acid has been researched along with 1-3-4-oxadiazole* in 1 studies

Other Studies

1 other study(ies) available for lipoteichoic-acid and 1-3-4-oxadiazole

Article	Year
Improved Antibacterial Activity of 1,3,4-Oxadiazole-Based Compounds That Restrict ACS infectious diseases, 2023, 11-10, Volume: 9, Issue:11 The lipoteichoic acid (LTA) biosynthesis pathway has emerged as a promising antimicrobial therapeutic target. Previous studies identified the 1,3,4 oxadiazole compound 1771 as an LTA inhibitor with activity against Gram-positive pathogens. We have succeeded in making six 1771 derivatives and, through subsequent hit validation, identified the incorporation of a pentafluorosulfanyl substituent as central in enhancing activity. Our newly described derivative, compound Topics: Animals; Anti-Bacterial Agents; Mammals; Methicillin-Resistant Staphylococcus aureus; Oxadiazoles; Staphylococcal Infections; Staphylococcus aureus	2023

Article

Year

Improved Antibacterial Activity of 1,3,4-Oxadiazole-Based Compounds That Restrict

ACS infectious diseases, 2023, 11-10, Volume: 9, Issue:11

The lipoteichoic acid (LTA) biosynthesis pathway has emerged as a promising antimicrobial therapeutic target. Previous studies identified the 1,3,4 oxadiazole compound 1771 as an LTA inhibitor with activity against Gram-positive pathogens. We have succeeded in making six 1771 derivatives and, through subsequent hit validation, identified the incorporation of a pentafluorosulfanyl substituent as central in enhancing activity. Our newly described derivative, compound

Topics: Animals; Anti-Bacterial Agents; Mammals; Methicillin-Resistant Staphylococcus aureus; Oxadiazoles; Staphylococcal Infections; Staphylococcus aureus

2023