Page last updated: 2024-09-03

lipid x and glycolipids

lipid x has been researched along with glycolipids in 67 studies

Compound Research Comparison

Studies
(lipid x)
Trials
(lipid x)
Recent Studies (post-2010)
(lipid x)
Studies
(glycolipids)
Trials
(glycolipids)
Recent Studies (post-2010) (glycolipids)
670619,0621705,050

Research

Studies (67)

TimeframeStudies, this research(%)All Research%
pre-199034 (50.75)18.7374
1990's24 (35.82)18.2507
2000's3 (4.48)29.6817
2010's6 (8.96)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Raetz, CR1
Brade, H; Feist, W; Flad, HD; Gerdes, J; Kusumoto, S; Musehold, J; Rietschel, HT; Ulmer, AJ; Wang, MH1
Hildebrandt, J; Lam, C; Liehl, E; Proctor, RA; Rosenwirth, B; Schütze, E; Stütz, P1
Golenbock, DT; Lynn, WA; Qureshi, N; Raetz, CR1
Akamatsu, Y; Arai, M; Hiraoka, T; Ishida, N; Kobayashi, Y; Kuge, S; Nishijima, M; Otsuka, T; Shiozaki, M1
Bertics, PJ; Leventhal, PS; Proctor, RA; Rhim, H; Tanke, T; van de Loo, JW1
Bosu, WT; Gaines, JD; Loro-Kujjo, G; Perez, GI; Peter, AT1
Macher, I; Schindlmaier, K; Scholz, D; Schütze, E; Vyplel, H1
Brade, H; Feist, W; Flad, HD; Rietschel, ET; Ulmer, AJ; Wang, MH1
Datta, P; Hunter, RL; Olsen, M; Takayama, K1
Danner, RL; Doerfler, ME; Parrillo, JE; Stuetz, P; Van Dervort, AL1
Harlan, JM; Kovach, NL; Munford, RS; Raetz, CR; Yee, E1
Hahnel, GB; Maier, RV; Pohlman, TH1
Brade, H; Feist, W; Flad, HD; Herzbeck, H; Kusumoto, S; Rietschel, ET; Ulmer, AJ; Wang, MH1
Hawiger, J; Romano, M1
Birkland, TP; Cornwell, RD; Golenbock, DT; Proctor, RA1
Aschauer, H; Grob, A; Hildebrandt, J; Schuetze, E; Stuetz, P1
Colwell, DE; Kirkland, TN; McGhee, JR; Michalek, SM; Ziegler, EJ1
Gartner, SL; Homer, LD; Kang, YH; Sieckmann, DG; Watson, LP1
Bradshaw, JD; Monroe, MC; Schwartz, BS1
Proctor, RA1
Brade, H; Feist, W; Flad, HD; Kusumoto, S; Loppnow, H; Rietschel, ET; Ulmer, AJ; Wang, MH1
Basalka, E; Lam, C; Schütze, E; Walzl, H2
Jirsa, RC; Walters, JD1
Cady, AB; Kotani, S; Krueger, JM; Kusumoto, S; Shiba, T1
Hauser, H; Lipka, G1
Akagawa, K; Akamatsu, Y; Amano, F; Nishijima, M1
Cole, FS; Strunk, RC; Sutton, MB1
Callahan, KS; Harlan, JM; Maier, RV; Pohlman, TH; Winn, RK1
Grabarek, J; Hawiger, J; Timmons, S1
Smith, RM1
Chung, J; Kugler, E; Macher, I; Sayers, TJ1
Raetz, CR; Sibley, CH; Terry, A1
Demel, RA; Hauser, H; Lipka, G1
Johnson, AG; Ribi, E; Tomai, MA1
Craig, WA; Golenbock, DT; Leggett, JE; Proctor, RA; Raetz, CR; Rasmussen, P1
Golenbock, DT; Proctor, RA; Raetz, CR; Will, JA1
Brade, L; Freudenberg, M; Galanos, C; Kusumoto, S; Lüderitz, O; Rietschel, ET; Schade, U; Shiba, T1
Ebert, S; Golenbock, DT; Proctor, RA; Will, JA1
Dijkstra, J; Mellors, JW; Ryan, JL; Szoka, FC1
Burhop, KE; Proctor, RA; Raetz, CR; Will, JA2
Brozek, KA; Bulawa, CE; Raetz, CR1
Danner, RL; Joiner, KA; Parrillo, JE1
Achiwa, K; Ikeda, K; Nakamoto, S; Shimizu, C; Takahashi, T2
Anderson, MS; Raetz, CR; Wightman, PD; Zoeller, RA1
Akamatsu, Y; Amano, F; Nishijima, M1
Akagawa, K; Akamatsu, Y; Amano, F; Nishijima, M; Raetz, CR; Tokunaga, T1
Burhop, KE; Helgerson, RB; Proctor, RA; Raetz, CH; Starling, JR; Will, JA1
Hildebrandt, J; Manthey, CL; Perera, PY; Stütz, PL; Vogel, SN1
Carlson, RW; Kelly, TM; Price, NP; Raetz, CR1
Flad, HD; Loppnow, H; Rietschel, ET; Ulmer, AJ1
Danner, RL; Doerfler, ME; Eichacker, PQ; Hoffman, WD; MacVittie, TJ; Natanson, C; Parrillo, JE; Reilly, JM; Stuetz, P; Wilson, J1
Arai, M; Deguchi, N; Kurakata, S; Macindoe, WM; Maeda, H; Miyazaki, H; Mochizuki, T; Ogawa, J; Shiozaki, M; Tatsuta, T1
Byrne, GI; Kalayoglu, MV1
Augy-Dorey, S; Billington, DC; Camara, JA; Gero, SD; Ghezzi, D; Quiclet-Sire, B; Sagnard, I1
Colella, M; Corcelli, A; Fanizzi, FP; Kates, M; Mascolo, G1
Ariga, T; Kasama, T; Kusunoki, S; Shiina, M; Suetake, K; Suzuki, M; Yu, RK1
Altobell, LJ; Boyle, NA; Janda, KD; Jones, LH; Lerner, RA; MacDonald, MT; Wentworth, P1
Guan, Z; Li, C; Liu, D; Raetz, CR1
Finer-Moore, JS; Lee, JK; Metzger, LE; Raetz, CR; Stroud, RM1
Barker, JR; Guan, Z; Valdivia, RH; Young, HE; Zhao, J; Zhou, P1
Kobayashi, M; Okada, C; Shinoda, A; Tanaka, I; Wakabayashi, H; Yao, M1
Cho, J; Lee, CJ; Young, HE; Zhao, J; Zhou, P1
Cho, J; Gillespie, RA; Hong, J; Kwak, SH; Kwon, DY; Lee, H; Lee, M; Park, HJ; Wu, Q; Zhao, J; Zhou, P1

Reviews

2 review(s) available for lipid x and glycolipids

ArticleYear
Endotoxin biosynthetic precursors: biologic and therapeutic activities.
    Progress in clinical and biological research, 1989, Volume: 299

    Topics: Animals; Endotoxins; Escherichia coli Infections; Glycolipids; Humans; Lipid A; Mice; Mice, Inbred C57BL; Sheep; Ticarcillin

1989
Agonists and antagonists for lipopolysaccharide-induced cytokines.
    Immunobiology, 1993, Volume: 187, Issue:3-5

    Topics: Acute-Phase Reaction; Animals; Cytokines; Escherichia coli; Glycolipids; Humans; Leukocytes, Mononuclear; Lipid A; Lipopolysaccharides; Salmonella typhimurium; Structure-Activity Relationship

1993

Other Studies

65 other study(ies) available for lipid x and glycolipids

ArticleYear
Lipid A disaccharide synthase from Escherichia coli.
    Methods in enzymology, 1992, Volume: 209

    Topics: Carbohydrate Sequence; Disaccharides; Escherichia coli; Glycolipids; Hexosyltransferases; Molecular Sequence Data; N-Acetylglucosaminyltransferases; Uridine Diphosphate N-Acetylglucosamine

1992
Inhibition of endotoxin or lipid A-induced tumor necrosis factor production by synthetic lipid A partial structures in human peripheral blood mononuclear cells.
    Lymphokine and cytokine research, 1992, Volume: 11, Issue:1

    Topics: Endotoxins; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Glycolipids; Humans; Interferon-gamma; Lipid A; Lipopolysaccharides; Monocytes; Recombinant Proteins; Salmonella; Staphylococcus aureus; Tumor Necrosis Factor-alpha

1992
Immunostimulatory, but not antiendotoxin, activity of lipid X is due to small amounts of contaminating N,O-acylated disaccharide-1-phosphate: in vitro and in vivo reevaluation of the biological activity of synthetic lipid X.
    Infection and immunity, 1991, Volume: 59, Issue:7

    Topics: Adjuvants, Immunologic; Animals; Antiviral Agents; Dinoprostone; Disaccharides; Dose-Response Relationship, Drug; Endotoxins; Female; Galactosamine; Glycolipids; Humans; In Vitro Techniques; Interleukin-1; Limulus Test; Macrophages; Mice; Mice, Inbred Strains; Monocytes; Neutrophils; Pyrogens; Rabbits; Shwartzman Phenomenon; Sugar Phosphates; Superoxides; Tumor Necrosis Factor-alpha

1991
Lipopolysaccharide-induced stimulation of CD11b/CD18 expression on neutrophils. Evidence of specific receptor-based response and inhibition by lipid A-based antagonists.
    Journal of immunology (Baltimore, Md. : 1950), 1991, Nov-01, Volume: 147, Issue:9

    Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; CD18 Antigens; Culture Media, Serum-Free; Cycloheximide; Dactinomycin; Dexamethasone; Disaccharides; Glycolipids; Humans; In Vitro Techniques; Lipid A; Lipopolysaccharide Receptors; Lipopolysaccharides; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Structure-Activity Relationship; Tumor Necrosis Factor-alpha; Up-Regulation

1991
Synthesis of 2-deoxy-2-[(3R)-3-hydroxytetradecanamido]-3-O-[(3R)-3- hydroxytetradecanyl]-alpha-D-glucopyranosyl dihydrogen phosphate and 2-deoxy-2-[(3R)-3-hydroxytetradecanamido]-3-O-[(3R)-3- hydroxytetradecanyl]-4-O-phosphono-D-glucopyranose.
    Carbohydrate research, 1991, Dec-30, Volume: 222

    Topics: Animals; Carbohydrate Conformation; Cell Death; Cell Line; Escherichia coli; Glycolipids; Indicators and Reagents; Macrophages; Magnetic Resonance Spectroscopy; Mice; Structure-Activity Relationship

1991
Bacterial lipopolysaccharide-stimulated GTPase activity in RAW 264.7 macrophage membranes.
    The Biochemical journal, 1991, Jul-15, Volume: 277 ( Pt 2)

    Topics: Adenosine Triphosphate; Animals; Cell Line; Cell Membrane; Escherichia coli; Fibroblasts; Glycolipids; GTP Phosphohydrolases; Kinetics; Lipopolysaccharides; Macrophages; Mice

1991
Serum cortisol changes in heifers induced by lipid X: a monosaccharide precursor in the biosynthesis of Gram-negative endotoxin.
    Research in veterinary science, 1991, Volume: 50, Issue:3

    Topics: Animals; Cattle; Endotoxins; Escherichia coli; Female; Glycolipids; Hydrocortisone; Lipopolysaccharides; Luteal Phase; Luteinizing Hormone

1991
C-glycosidic analogues of lipid A and lipid X: synthesis and biological activities.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:9

    Topics: Animals; Disaccharides; Glycolipids; Glycosides; Lipid A; Mice; Monosaccharides

1991
Induction and modulation of interleukin 1 production by defined partial structures of lipopolysaccharide.
    Behring Institute Mitteilungen, 1991, Issue:88

    Topics: Dose-Response Relationship, Drug; Escherichia coli; Glycolipids; Humans; Interleukin-1; Kinetics; Leukocytes, Mononuclear; Lipid A; Lipopolysaccharides

1991
Adjuvant activity of non-ionic block copolymers. V. Modulation of antibody isotype by lipopolysaccharides, lipid A and precursors.
    Vaccine, 1991, Volume: 9, Issue:4

    Topics: Adjuvants, Immunologic; Animals; Carbohydrate Sequence; Female; Glycolipids; Immunoglobulin G; Immunoglobulin Isotypes; Lipid A; Lipopolysaccharides; Mice; Molecular Sequence Data; Poloxalene

1991
Antiendotoxin activity of lipid A analogues: requirements of the chemical structure.
    Pharmaceutical research, 1990, Volume: 7, Issue:3

    Topics: Bacterial Infections; Chemical Phenomena; Chemistry; Endotoxins; Glycolipids; Humans; In Vitro Techniques; Lipid A; Myristic Acids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Sepsis; Superoxides; Trypan Blue

1990
Lipid IVA inhibits synthesis and release of tumor necrosis factor induced by lipopolysaccharide in human whole blood ex vivo.
    The Journal of experimental medicine, 1990, Jul-01, Volume: 172, Issue:1

    Topics: Acylation; Animals; Blood; Blotting, Northern; Cytotoxicity Tests, Immunologic; Fibroblasts; Glycolipids; Humans; Lipid A; Lipopolysaccharides; Recombinant Proteins; RNA, Messenger; Salmonella typhimurium; Tumor Necrosis Factor-alpha

1990
Endotoxin requirements for alveolar macrophage stimulation.
    The Journal of trauma, 1990, Volume: 30, Issue:12 Suppl

    Topics: Animals; Bacteroides fragilis; Blood Coagulation Factors; Cells, Cultured; Endotoxins; Escherichia coli; Glycolipids; Humans; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Multiple Organ Failure; Pulmonary Alveoli; Rabbits; Respiratory Distress Syndrome; Tumor Necrosis Factor-alpha

1990
Suppressive effect of lipid A partial structures on lipopolysaccharide or lipid A-induced release of interleukin 1 by human monocytes.
    FEMS microbiology immunology, 1990, Volume: 2, Issue:3

    Topics: Carbohydrate Sequence; Glycolipids; Humans; In Vitro Techniques; Interleukin-1; Lipid A; Lipopolysaccharides; Molecular Sequence Data; Molecular Structure; Monocytes

1990
Interaction of endotoxic lipid A and lipid X with purified human platelet protein kinase C.
    The Journal of biological chemistry, 1990, Jan-25, Volume: 265, Issue:3

    Topics: Blood Platelets; Blotting, Western; Calcium; Cell-Free System; Endotoxins; Enzyme Activation; Glycolipids; Humans; In Vitro Techniques; Isoelectric Point; Kinetics; Lipid A; Protein Kinase C

1990
Comparative study of lipopolysaccharide-, lipid IVa-, and lipid X-induced tumor necrosis factor production in murine macrophage-like cell lines.
    Advances in experimental medicine and biology, 1990, Volume: 256

    Topics: Animals; Cell Line; Glycolipids; Lipid A; Lipopolysaccharides; Macrophages; Mice; Tumor Necrosis Factor-alpha

1990
Highly purified lipid X is devoid of immunostimulatory activity. Isolation and characterization of immunostimulating contaminants in a batch of synthetic lipid X.
    The Journal of biological chemistry, 1990, Jun-05, Volume: 265, Issue:16

    Topics: Acylation; Adjuvants, Immunologic; Animals; Biological Assay; Bone Marrow Cells; Chromatography, Gel; Chromatography, High Pressure Liquid; Disaccharides; Drug Contamination; Female; Glycolipids; Macrophage Activation; Macrophages; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Myristic Acid; Myristic Acids; Sugar Phosphates; Tumor Necrosis Factor-alpha

1990
Analysis of the fine specificity and cross-reactivity of monoclonal anti-lipid A antibodies.
    Journal of immunology (Baltimore, Md. : 1950), 1986, Dec-01, Volume: 137, Issue:11

    Topics: Antibodies, Monoclonal; Antibody Specificity; Antigens, Bacterial; Binding, Competitive; Cross Reactions; Epitopes; Escherichia coli; Glycolipids; Lipid A; Salmonella

1986
Effects of lipopolysaccharide, lipid A, lipid X, and phorbol ester on cultured bovine endothelial cells.
    Laboratory investigation; a journal of technical methods and pathology, 1988, Volume: 59, Issue:2

    Topics: Animals; Cattle; Cell Adhesion; Cell Line; Cell Survival; DNA; Dose-Response Relationship, Drug; Endothelium, Vascular; Glycolipids; Lipid A; Lipopolysaccharides; Microscopy, Electron; Microscopy, Electron, Scanning; Protein Biosynthesis; RNA; Tetradecanoylphorbol Acetate

1988
Endotoxin-induced production of plasminogen activator inhibitor by human monocytes is autonomous and can be inhibited by lipid X.
    Blood, 1989, Volume: 73, Issue:8

    Topics: Cell Communication; Dose-Response Relationship, Immunologic; Endotoxins; Glycolipids; Glycoproteins; Humans; Immunoenzyme Techniques; Lipopolysaccharides; Lymphocytes; Monocytes; Plasminogen Inactivators; Staining and Labeling; Thromboplastin

1989
Interleukin 1 and tumor necrosis factor: studies on the induction by lipopolysaccharide partial structures.
    Lymphokine research, 1989,Fall, Volume: 8, Issue:3

    Topics: Glycolipids; Humans; In Vitro Techniques; Interleukin-1; Leukocytes, Mononuclear; Lipid A; Lipopolysaccharides; Tumor Necrosis Factor-alpha

1989
Protection of mice against lethal endotoxemia by lipid X is mediated through inhibition of neutrophil function.
    Circulatory shock, 1987, Volume: 22, Issue:4

    Topics: Animals; Cell Aggregation; Galactosamine; Glucuronidase; Glycolipids; Humans; In Vitro Techniques; Lipid A; Lipopolysaccharides; Lung Diseases; Male; Mice; Mice, Inbred C57BL; Neutrophils; Shock, Septic; Superoxides

1987
Activation of cyclic nucleotide phosphodiesterase by a monosaccharide precursor of Escherichia coli lipid A.
    FEBS letters, 1988, Aug-29, Volume: 236, Issue:2

    Topics: Calcineurin; Calcium; Calmodulin; Calmodulin-Binding Proteins; Enzyme Activation; Escherichia coli; Glycolipids; Lipid A; Monosaccharides; Phosphoprotein Phosphatases; Structure-Activity Relationship

1988
Somnogenic activities of synthetic lipid A.
    Infection and immunity, 1989, Volume: 57, Issue:2

    Topics: Animals; Body Temperature; Colon; Delta Rhythm; Glycolipids; Lipid A; Male; Rabbits; Sleep; Sleep, REM; Structure-Activity Relationship

1989
Phase behaviour of mixtures of lipid X with phosphatidylcholine and phosphatidylethanolamine.
    Biochimica et biophysica acta, 1989, Feb-27, Volume: 979, Issue:2

    Topics: Chromatography, Gel; Freeze Fracturing; Freezing; Glycolipids; Hot Temperature; Hydrogen-Ion Concentration; Lipid A; Lipid Bilayers; Liposomes; Magnetic Resonance Spectroscopy; Microscopy, Electron; Particle Size; Phosphatidylcholines; Phosphatidylethanolamines; Sonication; Spectrophotometry

1989
Enhancement of O2- generation and tumoricidal activity of murine macrophages by a monosaccharide precursor of Escherichia coli lipid A.
    FEBS letters, 1985, Nov-18, Volume: 192, Issue:2

    Topics: Animals; Cell Line; Cytotoxicity, Immunologic; Escherichia coli; Glycolipids; Leukemia, Experimental; Lipid A; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred ICR; Superoxides

1985
Regulation of the synthesis of the third component of complement and factor B in cord blood monocytes by lipopolysaccharide.
    Journal of immunology (Baltimore, Md. : 1950), 1986, Feb-15, Volume: 136, Issue:4

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Adult; Complement C3; Complement Factor B; Dexamethasone; Endotoxins; Enzyme Precursors; Female; Fetal Blood; Glycolipids; Humans; Indomethacin; Infant, Newborn; Lipopolysaccharides; Male; Monocytes; Phagocytosis; Superoxides

1986
A glycolipid precursor of bacterial lipopolysaccharide (lipid X) lacks activity against endothelial cells in vitro and is not toxic in vivo.
    The Journal of surgical research, 1988, Volume: 45, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cattle; Cells, Cultured; Endothelium, Vascular; Escherichia coli; Glycolipids; Goats; Leukocyte Count; Limulus Test; Lipid A; Lipopolysaccharides; Radioimmunoassay; Vibrio cholerae

1988
Modulation of human platelet protein kinase C by endotoxic lipid A.
    The Journal of clinical investigation, 1988, Volume: 82, Issue:3

    Topics: Blood Platelets; Blood Proteins; Endotoxins; Enzyme Activation; Escherichia coli; Glycolipids; Humans; Lipid A; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Serotonin; Tetradecanoylphorbol Acetate; Thromboxane-A Synthase; Type C Phospholipases

1988
Pulmonary oxygen toxicity in rats: prevention by pyrogenic diphosphoryl lipid A and potentiation by nontoxic monophosphoryl lipid A and lipid X.
    Research communications in chemical pathology and pharmacology, 1988, Volume: 62, Issue:2

    Topics: Animals; Drug Synergism; Endotoxins; Escherichia coli; Glycolipids; Lipid A; Male; Oxygen; Pulmonary Edema; Rats; Rats, Inbred Strains; Structure-Activity Relationship

1988
The production of tumor necrosis factor by mouse bone marrow-derived macrophages in response to bacterial lipopolysaccharide and a chemically synthesized monosaccharide precursor.
    Journal of immunology (Baltimore, Md. : 1950), 1987, May-01, Volume: 138, Issue:9

    Topics: Animals; Bone Marrow Cells; Cells, Cultured; Glycolipids; Glycoproteins; Interferon-gamma; Lipid A; Lipopolysaccharides; Macrophages; Mice; Neutralization Tests; Tumor Necrosis Factor-alpha

1987
Induction of kappa light chain synthesis in 70Z/3 B lymphoma cells by chemically defined lipid A precursors.
    The Journal of biological chemistry, 1988, Apr-15, Volume: 263, Issue:11

    Topics: Animals; B-Lymphocytes; Escherichia coli; Glycolipids; Immunoglobulin kappa-Chains; Lipid A; Lymphoma; Mice; RNA, Messenger; Salmonella typhimurium; Tumor Cells, Cultured

1988
Phase behaviour of lipid X.
    Chemistry and physics of lipids, 1988, Volume: 48, Issue:3-4

    Topics: Calorimetry, Differential Scanning; Chemical Phenomena; Chemistry; Chromatography, Gel; Densitometry; Glycolipids; Lipid A; Micelles; Microscopy, Electron; Particle Size; Solubility; Spectrometry, Fluorescence

1988
Glycolipid induced proliferation of lipopolysaccharide hyporesponsive C3H/HeJ splenocytes.
    Journal of leukocyte biology, 1988, Volume: 43, Issue:1

    Topics: Animals; Cell Division; Escherichia coli; Glycolipids; Lipid A; Lipopolysaccharides; Lymphocyte Activation; Male; Mice; Mice, Inbred C3H; Polymyxin B; Salmonella; Spleen

1988
Lipid X protects mice against fatal Escherichia coli infection.
    Infection and immunity, 1988, Volume: 56, Issue:4

    Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Escherichia coli Infections; Glycolipids; Mice; Penicillins; Sepsis; Ticarcillin

1988
Lipid X ameliorates pulmonary hypertension and protects sheep from death due to endotoxin.
    Infection and immunity, 1987, Volume: 55, Issue:10

    Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Temperature; Chemical Phenomena; Chemistry; Endotoxins; Escherichia coli; Escherichia coli Infections; Female; Glycolipids; Hydrogen-Ion Concentration; Hypertension, Pulmonary; Leukocyte Count; Lipid A; Male; Sheep

1987
Endotoxic properties of synthetic pentaacyl lipid A precursor Ib and a structural isomer.
    European journal of biochemistry, 1987, Nov-16, Volume: 169, Issue:1

    Topics: Animals; Antigens; Endotoxins; Escherichia coli; Fever; Glycolipids; Hemolysis; Lethal Dose 50; Lipid A; Macrophage Activation; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mitosis; Rabbits; Spleen

1987
Elimination and tissue distribution of the monosaccharide lipid A precursor, lipid X, in mice and sheep.
    Antimicrobial agents and chemotherapy, 1988, Volume: 32, Issue:1

    Topics: Animals; Chemical Phenomena; Chemistry; Glycolipids; Half-Life; Lipid A; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Sheep; Tissue Distribution

1988
Modulation of the biological activity of bacterial endotoxin by incorporation into liposomes.
    Journal of immunology (Baltimore, Md. : 1950), 1987, Apr-15, Volume: 138, Issue:8

    Topics: Animals; Cell Line; Cell Membrane; Cholesterol; Glycolipids; Interleukin-1; Limulus Test; Lipid A; Lipopolysaccharides; Liposomes; Macrophage Activation; Macrophages; Mice; Phagocytosis; Phosphatidylcholines; Phosphatidylserines; Salmonella

1987
Protection of mice against lethal endotoxemia by a lipid A precursor.
    Infection and immunity, 1986, Volume: 52, Issue:3

    Topics: Animals; Drug Administration Schedule; Endotoxins; Escherichia coli; Glycolipids; Lipid A; Mice; Shock, Septic; Structure-Activity Relationship

1986
Biosynthesis of lipid A precursors in Escherichia coli. A membrane-bound enzyme that transfers a palmitoyl residue from a glycerophospholipid to lipid X.
    The Journal of biological chemistry, 1987, Apr-15, Volume: 262, Issue:11

    Topics: Acyltransferases; Carbohydrate Conformation; Escherichia coli; Glycolipids; Lipid A; Magnetic Resonance Spectroscopy; Palmitic Acid; Palmitic Acids; Phosphatidic Acids; Protein Precursors; Spectrophotometry, Atomic

1987
Pulmonary pressor responses in sheep to chemically defined precursors of E. coli endotoxin.
    Journal of applied physiology (Bethesda, Md. : 1985), 1987, Volume: 62, Issue:3

    Topics: Animals; Blood Pressure; Escherichia coli; Glycolipids; Lung; Pulmonary Artery; Pulmonary Circulation; Sheep

1987
Inhibition of lipopolysaccharide-mediated activation of neutrophils with monosaccharide derivatives of lipid A.
    Progress in clinical and biological research, 1987, Volume: 236A

    Topics: Animals; Galactosamine; Glycolipids; Humans; In Vitro Techniques; Lipid A; Lipopolysaccharides; Lung; Mice; Mice, Inbred C57BL; Neutrophils; Oxygen

1987
Inhibition of endotoxin-induced priming of human neutrophils by lipid X and 3-Aza-lipid X.
    The Journal of clinical investigation, 1987, Volume: 80, Issue:3

    Topics: Dose-Response Relationship, Drug; Endotoxins; Glycolipids; Humans; Lipopolysaccharides; Neutrophils; Osmolar Concentration; Salmonella

1987
Lipid A and related compounds. XI. New, efficient synthesis of lipid X.
    Chemical & pharmaceutical bulletin, 1987, Volume: 35, Issue:4

    Topics: Chemical Phenomena; Chemistry; Glycolipids; Lipid A

1987
Accumulation of lysophosphatidylinositol in RAW 264.7 macrophage tumor cells stimulated by lipid A precursors.
    The Journal of biological chemistry, 1987, Dec-15, Volume: 262, Issue:35

    Topics: Animals; Calcium; Glycolipids; Lipid A; Lysophospholipids; Macrophages; Membrane Lipids; Phospholipids; Prostaglandins; Tumor Cells, Cultured

1987
A monosaccharide precursor of Escherichia coli lipid A has the ability to induce tumor-cytotoxic factor production by a murine macrophage-like cell line, J774.1.
    Journal of immunology (Baltimore, Md. : 1950), 1986, Jun-01, Volume: 136, Issue:11

    Topics: Animals; Cell Line; Cytotoxicity, Immunologic; Glycolipids; Glycoproteins; Lipid A; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Monosaccharides; Neoplasms, Experimental; Tumor Necrosis Factor-alpha

1986
Macrophage activation by monosaccharide precursors of Escherichia coli lipid A.
    Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:2

    Topics: Animals; Cytotoxicity, Immunologic; Dinoprostone; Escherichia coli; Glycolipids; Lipid A; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Peptones; Prostaglandins E

1985
A new methodology for chemoselection of one amino and four hydroxyl groups of glucosamine derivatives and its use for synthesis of lipid X.
    Chemical & pharmaceutical bulletin, 1985, Volume: 33, Issue:4

    Topics: Chemical Phenomena; Chemistry; Glucosamine; Glycolipids

1985
Pulmonary pathophysiological changes in sheep caused by endotoxin precursor, lipid X.
    Journal of applied physiology (Bethesda, Md. : 1985), 1985, Volume: 59, Issue:6

    Topics: Animals; Blood Gas Analysis; Chemical Phenomena; Chemistry; Glycolipids; Hemodynamics; Hypertension, Pulmonary; Lipopolysaccharides; Lung; Lymphatic System; Mathematics; Sheep

1985
Induction of early gene expression in murine macrophages by synthetic lipid A analogs with differing endotoxic potentials.
    Infection and immunity, 1993, Volume: 61, Issue:5

    Topics: Animals; Carbohydrate Sequence; Endotoxins; Female; Gene Expression; Glycolipids; In Vitro Techniques; Interleukin-1; Lipid A; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C3H; Phosphotyrosine; Protein-Tyrosine Kinases; RNA, Messenger; Structure-Activity Relationship; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine

1993
Biosynthesis of a structurally novel lipid A in Rhizobium leguminosarum: identification and characterization of six metabolic steps leading from UDP-GlcNAc to 3-deoxy-D-manno-2-octulosonic acid2-lipid IVA.
    Journal of bacteriology, 1994, Volume: 176, Issue:15

    Topics: Acetates; Acyltransferases; Amidohydrolases; Carbohydrate Sequence; Glycolipids; Lipid A; Models, Biological; Molecular Sequence Data; N-Acetylglucosaminyltransferases; Phosphates; Phosphotransferases (Alcohol Group Acceptor); Rhizobium leguminosarum; Sugar Acids; Transferases

1994
Therapeutic trial of lipid X in a canine model of septic shock.
    The Journal of infectious diseases, 1993, Volume: 167, Issue:2

    Topics: Animals; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Escherichia coli; Escherichia coli Infections; Glycolipids; Hemodynamics; Leukocyte Count; Random Allocation; Shock, Septic; Treatment Outcome

1993
Syntheses of 1-O-carboxyalkyl GLA-60 analogues.
    Carbohydrate research, 1996, Mar-22, Volume: 283

    Topics: Carbohydrate Conformation; Carbohydrate Sequence; Cells, Cultured; Escherichia coli; Glucosides; Glycolipids; Lipid A; Lipopolysaccharides; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Prednisolone; Salmonella; Tumor Necrosis Factor-alpha

1996
A Chlamydia pneumoniae component that induces macrophage foam cell formation is chlamydial lipopolysaccharide.
    Infection and immunity, 1998, Volume: 66, Issue:11

    Topics: Animals; Arteriosclerosis; Cell Differentiation; Cell Line; Chlamydophila pneumoniae; Cholesterol Esters; Foam Cells; Glycolipids; Growth Inhibitors; Lipopolysaccharides; Mice; Periodic Acid; Temperature

1998
Synthesis and biological evaluation of carbocyclic analogues of lipid X: new nonpolar antagonists of LPS induced TNF production.
    Drug design and discovery, 1999, Volume: 16, Issue:1

    Topics: Acids, Carbocyclic; Drug Interactions; Glycolipids; Humans; In Vitro Techniques; Lipopolysaccharides; Shock, Septic; Tumor Necrosis Factor-alpha

1999
A novel glycolipid and phospholipid in the purple membrane.
    Biochemistry, 2000, Mar-28, Volume: 39, Issue:12

    Topics: Bacteriorhodopsins; Glycolipids; Halobacterium salinarum; Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular; Phospholipids; Purple Membrane

2000
Characterization of a phospholipid antigen reacting with serum antibody in patients with peripheral neuropathies and paraproteinemia.
    Journal of neurochemistry, 2001, Volume: 79, Issue:5

    Topics: Animals; Antigen-Antibody Reactions; Antigens; Cattle; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Enzyme-Linked Immunosorbent Assay; Glycolipids; Humans; Immunoglobulin M; Immunohistochemistry; Paraproteinemias; Peripheral Nervous System Diseases; Phospholipids; Spectrometry, Mass, Fast Atom Bombardment

2001
Active immunization with a glycolipid transition state analogue protects against endotoxic shock.
    Angewandte Chemie (International ed. in English), 2002, Nov-15, Volume: 41, Issue:22

    Topics: Animals; Antibodies; Diphosphonates; Escherichia coli; Glycoconjugates; Glycolipids; Hemocyanins; Lipid A; Mice; Molecular Mimicry; Shock, Septic; Tumor Necrosis Factor-alpha; Vaccination; Vaccines, Synthetic

2002
Pathway for lipid A biosynthesis in Arabidopsis thaliana resembling that of Escherichia coli.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Jul-12, Volume: 108, Issue:28

    Topics: Acyltransferases; Arabidopsis; Base Sequence; Chromosome Mapping; DNA, Plant; Escherichia coli; Gene Knockdown Techniques; Gene Knockout Techniques; Genes, Plant; Glycolipids; Lipid A; Metabolic Networks and Pathways; Mitochondria; Molecular Structure; Mutation; Plants, Genetically Modified; Species Specificity

2011
LpxI structures reveal how a lipid A precursor is synthesized.
    Nature structural & molecular biology, 2012, Volume: 19, Issue:11

    Topics: Amino Acid Sequence; Caulobacter crescentus; Crystallization; DNA Mutational Analysis; Glycolipids; Isoenzymes; Lipid A; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Conformation; Protein Folding; Pyrophosphatases; Ultracentrifugation

2012
Discovery of the Elusive UDP-Diacylglucosamine Hydrolase in the Lipid A Biosynthetic Pathway in Chlamydia trachomatis.
    mBio, 2016, Mar-22, Volume: 7, Issue:2

    Topics: Biosynthetic Pathways; Chlamydia trachomatis; Escherichia coli; Gene Library; Genetic Testing; Glycolipids; Lipid A; Pyrophosphatases; Sequence Homology, Amino Acid

2016
Crystal structures of the UDP-diacylglucosamine pyrophosphohydrase LpxH from Pseudomonas aeruginosa.
    Scientific reports, 2016, 09-09, Volume: 6

    Topics: Bacterial Proteins; Catalytic Domain; Crystallography, X-Ray; Glycolipids; Hydrophobic and Hydrophilic Interactions; Lipid A; Models, Molecular; Mutation; Protein Binding; Protein Conformation; Pseudomonas aeruginosa; Pyrophosphatases

2016
Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis.
    Nature microbiology, 2016, Aug-15, Volume: 1, Issue:11

    Topics: Biocatalysis; Carbohydrate Metabolism; Crystallization; Crystallography, X-Ray; Glycolipids; Haemophilus influenzae; Hydrolysis; Lipid A; Models, Molecular; Pyrophosphatases; Substrate Specificity

2016
Structure-Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay.
    ACS infectious diseases, 2019, 04-12, Volume: 5, Issue:4

    Topics: Anti-Bacterial Agents; Aquifex; Bacteria; Bacterial Proteins; Biocatalysis; Enzyme Assays; Enzyme Inhibitors; Escherichia coli; Glycolipids; Phosphates; Piperazine; Pyrophosphatases; Rosaniline Dyes; Structure-Activity Relationship

2019