linsidomine and oxadiazoles

Topics: Coronary Angiography; Coronary Vasospasm; Coronary Vessels; Humans; Molsidomine; Oxadiazoles; Sydnones; Time Factors; Vasodilator Agents

Topics: Coronary Disease; Coronary Vessels; Double-Blind Method; Humans; Injections, Intra-Arterial; Molsidomine; Oxadiazoles; Random Allocation; Sydnones; Vasodilator Agents

Topics: Animals; Cations, Divalent; Cattle; Coronary Vessels; Cyclic GMP; Ferricyanides; Guanylate Cyclase; In Vitro Techniques; Methylene Blue; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Nitroprusside; Oxadiazoles; Sodium Nitrite; Sulfhydryl Compounds; Sydnones

Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; In Vitro Techniques; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Oxadiazoles; Sydnones; Vasodilator Agents

Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Endothelium; In Vitro Techniques; Methylene Blue; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Oxadiazoles; Phosphodiesterase Inhibitors; Sydnones; Time Factors; Vasodilation

Topics: Animals; Blood Volume; Coronary Vessels; Dogs; Molsidomine; Oxadiazoles; Stroke Volume; Sydnones; Vascular Resistance; Vasodilator Agents

Topics: Animals; Biological Availability; Coronary Disease; Dogs; Half-Life; Humans; Kinetics; Molsidomine; Oxadiazoles; Sydnones; Vasodilator Agents

Topics: Adult; Female; Half-Life; Hemodynamics; Humans; Kinetics; Male; Molsidomine; Oxadiazoles; Plethysmography, Impedance; Sydnones; Vasodilator Agents

Topics: Coronary Angiography; Coronary Vasospasm; Coronary Vessels; Female; Humans; Male; Middle Aged; Molsidomine; Oxadiazoles; Sydnones; Vasodilator Agents

Topics: Adenosine Diphosphate; Animals; Aspirin; Cats; Epoprostenol; Female; Fibrinolysis; Humans; In Vitro Techniques; Male; Molsidomine; Oxadiazoles; Platelet Aggregation; Rabbits; Sydnones

Topics: Animals; Coronary Vessels; Cyclic AMP; Cyclic GMP; Dogs; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Molsidomine; Muscle Contraction; Muscle, Smooth, Vascular; Nitroglycerin; Oxadiazoles; Sydnones; Vasodilator Agents

Topics: Antihypertensive Agents; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Humans; Molsidomine; Oxadiazoles; Phospholipids; Sydnones; Thromboxane B2

Topics: Animals; Arachidonic Acids; Blood Platelets; Drug Interactions; Female; Humans; Indoles; Male; Molsidomine; Oxadiazoles; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Pyridines; Rabbits; Sydnones; Thromboxane A2; Thromboxanes

Topics: Administration, Oral; Animals; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart Rate; Hemodynamics; Injections, Intravenous; Male; Microspheres; Molsidomine; Nitric Oxide; Oxadiazoles; Oxygen Consumption; Pulmonary Artery; Time Factors; Vasoconstriction; Vasodilation

Topics: Arachidonic Acid; Cell Adhesion; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Epoprostenol; Guanylate Cyclase; Humans; Molsidomine; Nitric Oxide; Nitroprusside; Oxadiazoles; Platelet Activating Factor; Thrombin; Umbilical Veins

Topics: Adenylyl Cyclases; Animals; Cyclic GMP; Cyclooxygenase Inhibitors; Diclofenac; Drug Interactions; Enzyme Inhibitors; Female; GTP-Binding Proteins; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Nucleotides, Cyclic; omega-N-Methylarginine; Oxadiazoles; Pertussis Toxin; Quinoxalines; Rats; Rats, Wistar; Sensitivity and Specificity; Sulfonamides; Uterine Contraction; Uterus; Vanadates; Vasodilator Agents; Virulence Factors, Bordetella

Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Carotid Arteries; Diethylamines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Male; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Oligopeptides; Oxadiazoles; Peptidyl-Dipeptidase A; Quinoxalines; Rabbits; Rats; Rats, Sprague-Dawley

Topics: Acetylcysteine; Animals; Biphenyl Compounds; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic GMP; Enzyme Activation; Free Radical Scavengers; Glomerular Mesangium; Glutathione; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molsidomine; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Onium Compounds; Oxadiazoles; Oxazines; Phosphorylation; Protein Processing, Post-Translational; Protein Tyrosine Phosphatases; Rats; S-Nitrosoglutathione; Second Messenger Systems

Topics: Animals; Cell Death; Cyclic GMP; Drug Synergism; Enzyme Inhibitors; Hydrogen Peroxide; Molsidomine; Neurons; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Superoxide Dismutase; Vasodilator Agents

Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; In Vitro Techniques; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Nitrogen Oxides; Oxadiazoles; Pulmonary Artery; Quinoxalines; Rats; Rats, Wistar; Spermine; Vasodilation

Topics: Animals; Calcium; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Growth Cones; Guanylate Cyclase; Hydrazines; Molsidomine; Mutagens; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Nitroprusside; Oxadiazoles; Pseudopodia; Quinoxalines; Snails; Sulfhydryl Reagents

Topics: Animals; Arginine; Diaphragm; Electric Stimulation; Enzyme Inhibitors; Female; In Vitro Techniques; Male; Molsidomine; Muscle Contraction; Muscle, Skeletal; Neuromuscular Junction; Nitroarginine; Oxadiazoles; Phrenic Nerve; Quinoxalines; Rats; Rats, Wistar; Synaptic Transmission

Topics: Animals; Deoxyglucose; Enzyme Inhibitors; Glucose; Guanylate Cyclase; Hypothalamus; Immunoenzyme Techniques; Male; Molsidomine; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Proto-Oncogene Proteins c-fos; Quinoxalines; Rats; Rats, Sprague-Dawley; Transcription Factor AP-1; Vasopressins

Topics: Aminoquinolines; Animals; Atrial Function; Catalase; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Heart Atria; Heart Ventricles; Hydroxyl Radical; Molsidomine; Muscle Fibers, Skeletal; Myocardial Contraction; Myocardium; Nitrates; Nitric Oxide Donors; Oxadiazoles; Oxidants; Quinoxalines; Rana esculenta; Sodium; Sodium-Calcium Exchanger; Ventricular Function

Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, fos; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Potassium Chloride; Proto-Oncogene Proteins c-fos; Pyridines; Quinoxalines; Rats; Sulfonamides

Topics: Animals; Cyclic GMP; Diethylamines; Drug Combinations; Enzyme Inhibitors; Glutathione; In Vitro Techniques; Male; Molsidomine; Myocardial Contraction; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nucleotides, Cyclic; Oxadiazoles; Oxidation-Reduction; Quinoxalines; Rats; Rats, Wistar; Superoxide Dismutase

Topics: Adenosine Triphosphate; Arginine; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Guanylate Cyclase; Humans; In Vitro Techniques; Molsidomine; Muscle, Smooth, Vascular; Nicorandil; Nitroarginine; Oxadiazoles; Potassium Channels; Pregnancy; Quinoxalines; Serotonin; Temperature; Umbilical Arteries; Vasodilation; Vasodilator Agents

Topics: Animals; Chronic Disease; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hemoglobins; Injections, Spinal; Ligation; Male; Molsidomine; Nerve Compression Syndromes; Neuralgia; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Sciatic Nerve

Topics: Animals; Bronchi; Cell Division; Cells, Cultured; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; Male; Molsidomine; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Peptides, Cyclic; Quinoxalines

Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Anguilla; Animals; Arginine; Atropine; Detergents; Enzyme Inhibitors; Female; Free Radical Scavengers; Heart; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Molsidomine; Muscarinic Antagonists; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Octoxynol; omega-N-Methylarginine; Ornithine; Oxadiazoles; Parasympatholytics; Pirenzepine; Quinoxalines; Superoxide Dismutase

Topics: Adrenergic beta-Agonists; Animals; Calcium; Calcium-Binding Proteins; Enzyme Inhibitors; Free Radical Scavengers; Humans; Isoproterenol; Molsidomine; Muscle Contraction; Myocardium; Myosin Light Chains; Nitric Oxide Donors; Oxadiazoles; Phosphorylation; Rats; Superoxide Dismutase; Troponin I

Topics: 4-Aminopyridine; Animals; Charybdotoxin; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Membrane Potentials; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Peptides; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Wistar; Vasodilation

Topics: 1-Methyl-3-isobutylxanthine; Aminoquinolines; Animals; Atrial Natriuretic Factor; Calcium Channels, L-Type; Carbachol; Cyclic AMP; Enzyme Inhibitors; Guinea Pigs; Molsidomine; Muscarinic Agonists; Myocardium; Nitric Oxide Donors; Oxadiazoles; Patch-Clamp Techniques; Second Messenger Systems

Topics: Animals; Apamin; Atropine; Calcium Channels; Charybdotoxin; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Ileum; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nifedipine; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Tetrodotoxin

Topics: Charybdotoxin; Cyclic GMP; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Humans; In Vitro Techniques; Labor, Obstetric; Molsidomine; Muscle Relaxation; Muscle, Smooth; Myometrium; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Oxytocin; Penicillamine; Peptides; Pregnancy; Quinoxalines; S-Nitrosothiols; Scorpion Venoms; Time Factors; Uterus

Topics: Adenine; Animals; Benzoates; Cattle; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Female; Guanylate Cyclase; Imidazoles; In Vitro Techniques; Mammary Arteries; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Oxadiazoles; Oxazines; Oxidants; Peroxynitrous Acid; Vasodilation; Vasodilator Agents

Topics: Cell Movement; Chemokine CCL11; Chemokines, CC; Chemotaxis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eosinophils; Guanylate Cyclase; Humans; Isoenzymes; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxadiazoles; Quinoxalines; Rhinitis, Allergic, Perennial; S-Nitroso-N-Acetylpenicillamine; Solubility

Topics: Barium; Calcium; Cell Line; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Humans; Intracellular Membranes; Membrane Potentials; Mitochondria; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Oxygen Consumption; Peroxynitrous Acid; Quinoxalines; Thapsigargin; Time Factors

Topics: Alkaloids; Amylases; Animals; Azepines; Benzoates; Benzylamines; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Carbazoles; Chelating Agents; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Gallic Acid; Genotype; Guanylate Cyclase; Imidazoles; In Vitro Techniques; Indoles; Male; Mice; Mice, Knockout; Molsidomine; Muscarinic Agonists; Myosin-Light-Chain Kinase; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Parotid Gland; Penicillamine; Phosphodiesterase Inhibitors; Pilocarpine; Protein Kinase Inhibitors; Pyrroles; Pyrrolidinones; Quinoxalines; Quinuclidines; Rats; Rats, Wistar; Sulfonamides; Thiophenes; Type C Phospholipases

Topics: Animals; Arginine; Bucladesine; Cyclic GMP; Dermis; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Subcutaneous; Male; Molsidomine; Nitric Oxide; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Subcutaneous Tissue; Time Factors

Topics: Animals; Antioxidants; Ascorbic Acid; Calcium; Calcium Channel Blockers; Cyclic GMP; Dialysis; Dopamine; Drug Interactions; In Vitro Techniques; Molsidomine; Nifedipine; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; PC12 Cells; Potassium; Rats; Signal Transduction; Time Factors

Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Esophagogastric Junction; In Vitro Techniques; Indomethacin; Male; Methylene Blue; Molsidomine; Muscle Relaxation; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Signal Transduction; Vasoactive Intestinal Peptide

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Isoenzymes; Lactones; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Pain; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Wistar; Sulfones; Uric Acid

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Animals; Atrial Natriuretic Factor; Biological Transport; Cardiac Pacing, Artificial; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Inhibitors; Guanylate Cyclase; Heart Atria; Milrinone; Molsidomine; Myocardial Contraction; Myocytes, Cardiac; Natriuretic Peptide, C-Type; Nitric Oxide Donors; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazoles; Pyridines; Quinoxalines; Rabbits; Receptors, Cytoplasmic and Nuclear; Second Messenger Systems; Soluble Guanylyl Cyclase; Stroke Volume

Topics: Adenosine Triphosphate; Animals; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Glyburide; Guinea Pigs; Indoles; Ion Channel Gating; Male; Membrane Potentials; Molsidomine; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Patch-Clamp Techniques; Potassium Channels; Quinoxalines; Signal Transduction; Urinary Bladder

Topics: Acetylcholine; Animals; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Injections, Intravenous; Insulin Resistance; Liver; Male; Molsidomine; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Portal Vein; Quinoxalines; Rats; Rats, Wistar; Signal Transduction

Topics: Acetylcholine; Actins; Animals; Atrial Natriuretic Factor; Body Weight; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Guanylate Cyclase; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Lung; Male; Molsidomine; Muscle, Smooth; Oxadiazoles; Piperazines; Pulmonary Artery; Purines; Quinoxalines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones; Systole; Vasodilation; Vasodilator Agents

Topics: Animals; Bronchi; Calcium; Cattle; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Guanylate Cyclase; In Vitro Techniques; Molsidomine; Muscle Relaxation; Nitric Oxide; Nitric Oxide Donors; Ouabain; Oxadiazoles; Peptides; Potassium; Quinoxalines; S-Nitrosoglutathione; Serotonin; Sodium-Potassium-Exchanging ATPase; Thionucleotides; Triazoles

Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Anguilla; Animals; Arginine; Bicarbonates; Chlorides; Cyclic GMP; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Intestinal Absorption; Intestinal Mucosa; Intestines; Membrane Potentials; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Permeability; Quinoxalines; Time Factors

Topics: Animals; Catheterization; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escape Reaction; Guanylate Cyclase; Male; Microinjections; Molsidomine; Motor Activity; Multivariate Analysis; Nitric Oxide Donors; Oxadiazoles; Periaqueductal Gray; Quinoxalines; Random Allocation; Rats; Rats, Wistar; Time Factors; Triazenes

Topics: Animals; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Guanylate Cyclase; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Sheep; Sphincter of Oddi; Triazenes

Topics: Actins; Analysis of Variance; Angioplasty, Balloon, Coronary; Animals; Coronary Angiography; Coronary Restenosis; Coronary Vessels; Cyclic GMP; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Guanylate Cyclase; Hyperplasia; Intermediate Filaments; Molsidomine; Myosins; NAD(P)H Dehydrogenase (Quinone); NADP; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Signal Transduction; Sus scrofa; Time Factors; Tunica Intima

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenal Medulla; Animals; Benzoates; Bombesin; Brain; Catecholamines; Cysteine; Dithiothreitol; Dose-Response Relationship, Drug; Ethylmaleimide; Imidazoles; Injections, Intraventricular; Male; Molsidomine; Nitric Oxide Donors; Oxadiazoles; Paraventricular Hypothalamic Nucleus; Quinoxalines; Rats; Rats, Wistar; S-Nitrosothiols; Sulfhydryl Reagents

Topics: Animals; Dose-Response Relationship, Drug; Male; Molsidomine; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Penicillamine; Peroxynitrous Acid; Pulmonary Artery; Quinoxalines; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents

Topics: Analgesics, Opioid; Animals; Drug Tolerance; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Male; Molsidomine; Morphine; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Photosensitizing Agents; Protoporphyrins; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Restriction Mapping; S-Nitroso-N-Acetylpenicillamine; Soluble Guanylyl Cyclase