linsidomine has been researched along with molsidomine in 1387 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 74 (5.34) | 18.7374 |
| 1990's | 651 (46.94) | 18.2507 |
| 2000's | 556 (40.09) | 29.6817 |
| 2010's | 102 (7.35) | 24.3611 |
| 2020's | 4 (0.29) | 2.80 |
| Authors | Studies |
|---|---|
| Braun, MS; Heckenberger, RE; Klockenbusch, W; Schröder, H; Schrör, K; Strobach, H | 1 |
| Berdeaux, A; Drieu la Rochelle, C; Giudicelli, JF; Richard, V | 1 |
| Piessens, J; Vrolix, M | 1 |
| Auch-Schwelk, W; Bossaller, C; Fleck, E; Götze, S; Graf, K; Gräfe, M; Weber, F | 1 |
| Gruber, C; Herrmann, C; Kessler, E; Ostrowski, J; Schraven, E; Stockhausen, H | 1 |
| Advenier, C; Cohen-Solal, A; Gourgon, R; Himbert, C; Himbert, D; Jaeger, P; Spreux-Varoquaux, O | 1 |
| Butt, E; Geiger, J; Nolte, C; Sage, SO; Walter, U | 1 |
| Darley-Usmar, VM; Hogg, N; Moncada, S; Wilson, MT | 2 |
| Dembinska-Kiéc, A; Pallapies, D; Peskar, BA; Simmet, T; Thelen, KI | 1 |
| Bockaert, J; Desagher, S; Deshager, S; Fagni, L; Manzoni, O; Marin, P; Prezeau, L | 1 |
| Bosia, A; Bussolino, F; Garbarino, G; Ghigo, D; Heller, R; Pescarmona, G; Till, U | 1 |
| Ervens, J; Seifert, R | 1 |
| Arvola, P; Huhtala, H; Metsä-Ketelä, T; Pörsti, I; Vapaatalo, H; Vuorinen, P | 1 |
| Braida, C; Holzmann, S; Kukovetz, WR; Pöch, G | 1 |
| Andersson, KE; Hedlund, H; Holmquist, F | 1 |
| Dean, RT; Gieseg, SP; Jessup, W; Mohr, D; Stocker, R | 1 |
| Chap, H; Gassama-Diagne, A; Simon, MF | 1 |
| Gryglewski, RJ; Salvemini, D; Taylor, GW; Vane, JR; Zembowicz, A | 1 |
| Darley-Usmar, VM; Hogg, N; Moncada, S; O'Leary, VJ; Wilson, MT | 1 |
| Duarte, ID; Ferreira, SH | 1 |
| Bucher, B; Ouedraogo, S; Paya, D; Stoclet, JC; Tschöpl, M | 1 |
| Darius, H; Grodzinska, L; Meyer, J | 1 |
| Schmid, M; Yeates, RA | 1 |
| Vuorinen, P | 1 |
| Howlett, A; Klein, C; Tao, Y | 2 |
| Schini, VB; Vanhoutte, PM | 3 |
| Philippu, A; Prast, H | 1 |
| Dembińska-Kieć, A; Jirmann, KU; Pallapies, D; Peskar, BA; Rademann, J; Rutowski, J; Simmet, T | 1 |
| Andersson, KE; Igawa, Y; Mattiasson, A; Persson, K | 1 |
| Andersson, KE; Djamilian, M; Holmquist, F; Jonas, U; Krah, H; Stief, CG | 1 |
| Benyó, Z; Csáki, C; Kovách, AG; Reivich, M; Szabó, C | 1 |
| Cheadle, HA; Groves, PH; Lewis, MJ; Penny, WJ | 2 |
| Ellis, JL; Undem, BJ | 1 |
| Nagao, T; Vanhoutte, PM | 1 |
| Egloff, L; Lüscher, TF; Siebenmann, R; Studer, M; Yang, Z | 1 |
| Brüne, B; Dimmeler, S; Lottspeich, F | 1 |
| Nathanson, JA | 1 |
| Lautt, WW | 1 |
| Dembińska-Kieć, A; Pallapies, D; Peskar, BA; Simmet, T; Thelen, K | 1 |
| Bourchier, RG; Gloviczki, P; Komori, K; Schini, VB; Vanhoutte, PM | 1 |
| Coves, J; Fieschi, F; Fontecave, M; Lepoivre, M; Thelander, L | 1 |
| Garthwaite, J; Southam, E | 2 |
| Duarte, ID; Ferreira, SH; Lorenzetti, BB | 1 |
| Busse, R; Mordvintcev, P; Mülsch, A; Vanin, A | 1 |
| Feelisch, M; Noack, E | 1 |
| Batchelor, AM; East, SJ; Garthwaite, J | 1 |
| Henry, PJ; Horowitz, JD; Louis, WJ | 2 |
| Ney, P; Schröder, H; Schrör, K; Woditsch, I | 2 |
| Berkenboom, G; Fang, ZY; Fontaine, J; Unger, P | 1 |
| Cathignol, D; de Lorgeril, M; Delaye, J; Ovize, M; Renaud, S | 1 |
| Bowen, R; Haslam, RJ | 1 |
| Förster, S; Schröder, H; Schrör, K; Woditsch, I | 2 |
| Bianchi, S; Gambassi, F; Lupini, M; Mannaioni, PF; Masini, E; Mugnai, L; Pistelli, A | 1 |
| Dembinska-Kiec, A; Pallapies, D; Peskar, BA; Peskar, BM; Simmet, T | 1 |
| Laustiola, KE; Manninen, V; Metsä-Ketelä, T; Pörsti, I; Vapaatalo, H; Vuorinen, P | 1 |
| Erhardt, J; Lefer, AM; Ma, XL; Rider, T; Siegfried, MR | 1 |
| Drummer, C; Gerzer, R; Lüdke, S; Schramm, W; Spannagl, M | 1 |
| Altorjay, I; Bellinger, O; Breddin, HK; Kirchmaier, CM | 1 |
| Bassenge, E | 1 |
| Bernards, W; Jumpertz, K; Klaus, W; Kreie, KJ; Rösen, R; Wiesmüller, G | 1 |
| Schrör, K | 1 |
| Drummer, C; Gerzer, R; Heim, JM; Karrenbrock, B; Niederreiter, B | 1 |
| Advenier, C; Andrieu, J; Cordonnier, P; Doll, J; Dutot, C; Grandjean, N; Pays, M; Spreux-Varoquaux, O | 1 |
| Berdeaux, A; Drieu la Rochelle, C; Giudicelli, JF; Gosgnach, M; Richard, V | 1 |
| Criscione, L; Lüscher, TF; Tschudi, MR | 1 |
| Alam, AS; Datta, HK; Hecker, M; Lidbury, PS; MacIntyre, I; Moonga, BS; Vane, JR; Zaidi, M | 1 |
| Crankshaw, D; Haslam, RJ; Maurice, DH | 1 |
| Förster, S; Schrör, K; Woditsch, I | 1 |
| Berkenboom, G; Bohyn, M; Fontaine, J | 1 |
| Thulesius, O; Yousif, F; Yousif, MH | 1 |
| Kober, G; Schulz, W | 1 |
| Advenier, C; Cordonnier, P; Ducreuzet, C; Forestier, A; Pays, M; Spreux-Varoquaux, O; Ulmer, B | 1 |
| Ney, P; Schröder, H; Schrör, K | 1 |
| Berthaud, T; Duranton, B; Gerenton, C; Guy, JM; Lamaud, M; Verneyre, H | 1 |
| De Geest, H; Piessens, J; Vrolix, M | 1 |
| Dembińska-Kieć, A; Gryglewski, RJ; Marcinkiewicz, J; Sinzinger, H; Zmuda, A | 1 |
| Dutrillaux, F; Lecompte, T; Potevin, F | 1 |
| Drobinski, G; Montalescot, G | 1 |
| Gulba, D; Hecker, H; Jost, S; Knop, I; Lichtlen, PR; Rafflenbeul, W; Reil, GH | 1 |
| Gaál, J; Knopf, E; Körmöczy, PS; Vértesi, C | 1 |
| Knopf, E; Körmöczy, PS; Vértesi, C | 1 |
| Gerzer, R; Heim, JM; Karrenbrock, B | 1 |
| Haslam, RJ; Maurice, DH | 1 |
| Drummer, C; Gerzer, R; Heim, JM; Karrenbrock, B | 2 |
| Darius, H; Erbel, R; Meyer, J; Pop, T; Rupprecht, HJ | 1 |
| Advenier, C; Cordonnier, P; Dutot, C; Gärtner, W; Klein, C; Moreau, J; Ostrowski, J; Pays, M; Spreux-Varoquaux, O | 1 |
| Berkenboom, G; Degre, S; Fontaine, J | 1 |
| Chap, H; Simon, MF | 1 |
| Bult, H; Fret, HR; Herman, AG | 1 |
| Vanhoutte, PM | 1 |
| Bassenge, E; Mülsch, A | 1 |
| Berkenboom, G; Fontaine, J; Unger, P | 2 |
| Holzmann, S; Kukovetz, WR | 5 |
| Förstermann, U; Kuhn, M | 1 |
| Claeys, M; Leusen, I; Van de Voorde, J | 1 |
| Bohn, H; Schönafinger, K | 1 |
| Komori, K; Vanhoutte, PM | 1 |
| Miller, VM; Vanhoutte, PM | 1 |
| Katusic, ZS; Vanhoutte, PM | 1 |
| Lüscher, TF; Richard, V; Yang, ZH | 1 |
| Bassenge, E; Busse, R; Mülsch, A; Pohl, U | 1 |
| Flavahan, NA; Vanhoutte, PM | 1 |
| Bordet, JC; Croset, M; Lagarde, M | 2 |
| Berenger, FP; Bodard, H; Esclapez, F; Friggi, A; Rolland, PH | 1 |
| Degre, S; Depelchin, P; Ibrahim, TM; Jottrand, M; Sobolski, J; Unger, PH | 1 |
| Auricchio, A; Frombach, R; Gulba, D; Hecker, H; Jost, S; Knop, I; Lichtlen, P; Rafflenbeul, W; Reil, G | 1 |
| Kukovetz, WR; Romanin, C | 1 |
| Bassenge, E; Busse, R; Mülsch, A | 1 |
| Chap, H; Douste-Blazy, L; Simon, MF | 2 |
| Kukovetz, WR; Schmidt, K | 1 |
| Gerzer, R; Grewe, R; Karrenbrock, B; Loeschke, K | 1 |
| Bourgoin, S; Harbon, S; Leiber, D | 1 |
| Gerzer, R; Heim, JM; Karrenbrock, B; Siess, W | 1 |
| Hader, S; Leitold, M | 1 |
| Schulz, W | 1 |
| Darius, H; Erbel, E; Meyer, J; Reusch, U; Schmucker, B | 1 |
| Wautier, JL | 1 |
| Balteaux, V | 1 |
| Borgeat, P; Bourgoin, S; Poubelle, P | 1 |
| Bassenge, E; Stewart, DJ | 1 |
| Hoffmann, A; Kloecking, HP; Markwardt, F | 1 |
| Astoin, M; Canton-Poincelot, B; Masson, A; Russo-Marie, F | 1 |
| Lüthy, C; Oetliker, O; Perisic, M; Pfaffli, D; Siegrist, M | 1 |
| Bordet, JC; Lagarde, M | 1 |
| Freisleben, HJ; Fuchs, J; Mainka, L; Zimmer, G | 1 |
| Amsterdam, EA | 1 |
| Berkenboom, GM; Degre, SG; Jottrand, M; Loiseau, J; Pype, F; Unger, P | 1 |
| Levy-Toledano, S; Maclouf, J; Rendu, F; Weill, D | 1 |
| Benveniste, J; Nunez, D; Russo-Marie, F | 1 |
| Breddin, HK; Weichert, W | 1 |
| Basista, M; Grodzinska, L; Koenig, E | 1 |
| Daret, D; Dorian, B; Larrue, J | 1 |
| Berenger, FP; Cano, JP; Rolland, PH | 1 |
| Chadha, D; Deckers, JW; Hugenholtz, PG; Luijten, HE; Reiber, JH; Serruys, PW; Tijssen, JG | 1 |
| Hoffmann, A; Klöcking, HP; Markwardt, F | 1 |
| Chamberlain, J; Gärtner, W; Ostrowski, J; Stockhausen, H; Wildgrube, HJ | 1 |
| Bassenge, E; Pohl, U | 1 |
| Ostrowski, J; Resag, K | 1 |
| Brandstätter, A; Gärtner, W; Jähnchen, E; Meinertz, T; Ostrowski, J; Trenk, D | 1 |
| Bernauer, R; Kaltenbach, M; Kober, G; Schulz, W | 1 |
| Berkenboom, G; Degre, S; Sobolski, J; Stoupel, E; Vandermoten, P | 1 |
| Abramowicz, M; Berkenboom, G; Degré, S; Sobolski, J; Stoupel, E; Vandermoten, P | 1 |
| Basista, M; Grodzińska, L; Swies, J | 1 |
| Hidaka, H; Nishikawa, M; Yamakado, T | 1 |
| Cingolani, H; Rinaldi, G | 1 |
| Karsch, KR; Niemczyk, P; Seipel, L; Voelker, W | 1 |
| Croset, M; Lagarde, M | 1 |
| Kober, G; Scherer, D; Schulz, W; Wendt, T | 1 |
| Block, HU; Förster, W; Heinroth, I | 1 |
| Akarid, K; Desforges, B; Gougerot-Pocidalo, MA; Sinet, M | 1 |
| Bult, H; De Meyer, GR; Feelisch, M; Herman, AG; Kockx, MM; Ustünes, L | 1 |
| Giles, WR; Han, X; Shimoni, Y | 1 |
| Adnot, S; Castaigne, A; Dubois-Rande, JL; Dupouy, P; Geschwind, H | 2 |
| Klockenbusch, W; Schrör, K | 1 |
| Drapier, JC; Hirling, H; Kaldy, P; Kühn, LC; Wietzerbin, J | 2 |
| Bond, R; Gao, Y; Illiano, S; Junquero, DC; Mombouli, JV; Nagao, T; Schini, VB; Smart, F; Vanhoutte, PM | 1 |
| Bockaert, J; Culcasi, M; Gaven, F; Lafon-Cazal, M; Pietri, S | 1 |
| Beaufils, P; Delonca, J; Foucher-Lavergne, A; Kolsky, H; Spreux-Varoquaux, O | 1 |
| Adnot, S; Blouquit, Y; Carville, C; Eddahibi, S; Raffestin, B | 1 |
| Aleppo, G; Canonico, PL; Scapagnini, U; Sortino, MA | 1 |
| Aleskowitch, TD; Flavahan, NA; Murray, PA | 1 |
| Cunningham, JM; Delaney, CA; Elphick, MR; Green, IC; Green, MH; Mabley, JG | 1 |
| Grünberg, B; Luber, K; Siess, W | 1 |
| Koch, B; Lutz-Bucher, B | 1 |
| Iadecola, C; Xu, X; Zhang, F | 1 |
| Choi, DW; Csernansky, CA; Hewett, SJ | 1 |
| Garg, LC; Guzman, NJ; Madsen, KM; Tisher, CC; Tojo, A | 1 |
| Conanan, ND; Ellis, JL | 1 |
| Boulu, RG; Buisson, A; Lakhmeche, N; Plotkine, M; Verrecchia, C | 1 |
| Balla, I; Dawson, TM; Kovách, AG; Lohinai, Z; Marczis, J; Snyder, SH | 1 |
| Dollinger, SJ; Wahler, GM | 1 |
| Mora, F; Porras, A; Segovia, G | 1 |
| Dymshitz, J; Vasko, MR | 1 |
| Akesson, B; Lundquist, I; Panagiotidis, G; Rydell, EL | 1 |
| Di Rosa, M; Ialenti, A; Ianaro, A; Sautebin, L | 1 |
| Bara, A; Busse, R; Mülsch, A; Schini-Kerth, V | 1 |
| Bockaert, J; Fagni, L; Lafon-Cazal, M; Lerner-Natoli, M; Manzoni, O; Rondouin, G | 1 |
| Patel, MJ; Rimele, TJ; Rose, DA; Wiseman, JS; Wypij, DM | 1 |
| Golenhofen, K; Höppner, CK; Jonas, U; Mandrek, K; Noack, T; Stief, CG | 1 |
| Gryglewski, RJ; Swies, J | 1 |
| Shibata, S; Tanaka, T; Watanabe, S; Yamamoto, Y | 1 |
| Bousquet, J; Dugas, B; Paul-Eugène, N; Pène, J | 1 |
| Grünberg, B; Negrescu, E; Siess, W | 1 |
| Armstrong, R; Heptinstall, S; Lösche, W; May, JA | 1 |
| De Caterina, R; Gimbrone, MA; Liao, JK; Libby, P; Peng, HB; Rajavashisth, TB; Shin, WS; Thannickal, VJ | 1 |
| Abelli, L; Barnes, PJ; Belvisi, MG; Polak, JM; Springall, DR; Tadjkarimi, S; Ward, JK; Yacoub, MH | 1 |
| Braun, M; Hohlfeld, T; Kienbaum, P; Sarbia, M; Schrör, K; Weber, AA | 1 |
| Eneroth, PH; Nilsson, CG; Xiao, L | 1 |
| Furukawa, T; Kohno, H; Taketani, S; Tokunaga, R | 1 |
| Darius, H; Fisch, A; Meyer, J; Michael-Hepp, J | 1 |
| Balla, I; Kovách, AG; Lohinai, Z; Marczis, J; Vass, Z | 2 |
| Brayden, JE; Murphy, ME | 1 |
| Andrew, PJ; Harant, H; Lindley, IJ | 1 |
| Akiyama, Y; Enomoto, K; Fukuda, M; Kimura, Y; Maeno, T; Moritake, K; Yamasaki, T | 1 |
| Nagy, E; Neumannova, V; Ponka, P; Richardson, DR | 1 |
| Losser, MR; Pastor, CM; Payen, D | 1 |
| Beauvais, F; Dubertret, L; Michel, L | 1 |
| Duran, D; Horwitz, J; Ischiropoulos, H | 1 |
| Bosmans, JM; Bult, H; Herman, AG; Vrints, CJ | 1 |
| Cieślik, K; Gryglewski, RJ; Korbut, R; Marcinkiewicz, E | 1 |
| Bohn, H; Brendel, J; Martorana, PA; Schönafinger, K | 1 |
| Hempelmann, RG; Herzig, S; Papadopoulos, I | 1 |
| Bockaert, J; Fagni, L; Lafon-Cazal, M; Olivier, M | 1 |
| Campbell, G; De Groote, MA; Fang, FC; Granger, D; Prince, R; Xu, Y | 1 |
| Maronde, E; Mayer, B; Middendorff, R; Olcese, J | 1 |
| Bult, H; De Meyer, GR; Herman, AG | 1 |
| Darley-Usmar, V; Moore, KP; Morrow, J; Roberts, LJ | 2 |
| Bonaventura, J; Doty, E; Haney, AF; Weinberg, JB | 1 |
| Kubes, P; Payne, D; Reinhardt, PH; Woodman, RC | 1 |
| Ankarcrona, M; Bonfoco, E; Krainc, D; Lipton, SA; Nicotera, P | 1 |
| Bockaert, J; Glowinski, J; Marin, P; Maus, M; Prémont, J | 1 |
| deGroot, H; Hensel, M; Ioannidis, I; Kox, WJ; Volk, T | 1 |
| Antunes, E; Bizeto, L; de Nucci, G; Mariani-Pedroso, SR; Zatz, R | 1 |
| Barnes, PJ; Belvisi, MG; Tadjkarimi, S; Ward, JK; Yacoub, MH | 1 |
| Cameselle, JC; Canales, J; Costas, MJ; Fernández, A; Pinto, RM; Ribeiro, JM | 1 |
| Inoue, S; Kawanishi, S | 1 |
| Hughes, H; Joly, GA; Schini, VB; Vanhoutte, PM | 1 |
| Cederbaum, AI; Gergel, D; Misík, V; Ondrias, K | 1 |
| Cunningham, JM; Delaney, CA; Green, IC; Karmiris, V; Southern, C | 1 |
| Becquet, F; Courtois, Y; Goureau, O; Lepoivre, M | 1 |
| Costa, A; Forsling, ML; Grossman, A; Trainer, P; Windle, R; Yasin, S | 1 |
| Darius, H; Meyer, J; Spiecker, M | 1 |
| Karp, M; Virta, M; Vuorinen, P | 1 |
| Abrams, SE; Clarkson, MJ; Coker, SJ; Walsh, KP | 1 |
| Eigler, A; Endres, S; Moeller, J | 1 |
| Calver, AL; Collier, J; MacAllister, RJ; Riezebos, J; Vallance, P | 1 |
| Bosia, A; Bussolino, F; Calvino, R; Gasco, A; Ghigo, D; Heller, R; Pescarmona, GP; Till, U | 1 |
| Schrör, K; Woditsch, I | 1 |
| Alanko, J; Lähteenmäki, T; Mucha, I; Riutta, A; Sievi, E; Vapaatalo, H | 1 |
| Porst, H | 2 |
| Pastor, CM; Payen, DM | 1 |
| Caputi, AP; Cook, JA; Halushka, PV; Zingarelli, B | 1 |
| Cayabyab, FS; Daniel, EE | 2 |
| Neumannova, V; Ponka, P; Richardson, DR | 1 |
| Alanko, J; Mucha, I; Riutta, A; Vapaatalo, H | 1 |
| Freeman, BA; Harrison, DG; Münzel, T; Sayegh, H; Tarpey, MM | 1 |
| Johnston, HM; Morris, BJ | 2 |
| Bosnjak, ZJ; Coughlan, MG; Kampine, JP; Kenny, D; Montgomery, RR; Warltier, DC | 1 |
| Dubois-Randé, JL; Dupouy, P; el Ghalid, A; Gallot, D; Geschwind, HJ; Larrazet, F; Pelle, G | 1 |
| Bynoe, TC; Hirshman, CA; Lindeman, KS; Stuart-Smith, K | 1 |
| Bialecki, RA; Stinson-Fisher, C | 1 |
| Beckman, JS; Brunelli, L; Crow, JP | 1 |
| Baczyńska, E; Dembińska-Kieć, A; Goldsztajn, P; Gryglewski, R; Miszczuk-Jamska, B; Przewłocki, R; Sowa, G; Wybrańska, I | 1 |
| Klän, R; Knispel, HH; Meier, T; Miller, K; Wegner, HE | 2 |
| Damais, C; Dugas, B; Kolb, JP; Paul-Eugène, N; Yamaoka, K | 1 |
| Bénardeau, A; Fischmeister, R; Hatem, S; Kirstein, M; Mercadier, JJ; Rivet-Bastide, M | 1 |
| Bouriquet, N; Casellas, D | 1 |
| Illiano, S; Mombouli, JV; Olmos, L; Vanhoutte, PM | 1 |
| Arias, IM; Dufour, JF; Turner, TJ | 1 |
| Cirino, G; Reuter, BK; Wallace, JL | 1 |
| Barnes, CS; Coker, SJ | 1 |
| Beckman, JS; Crow, JP; McCord, JM | 1 |
| Andre, A; Andriantsitohaina, R; Lagaud, GJ; Muller, B; Stoclet, JC | 1 |
| Belhassen, L; Fischmeister, R; Méry, PF; Pavoine, C; Pecker, F | 1 |
| Meffert, MK; Premack, BA; Schulman, H | 1 |
| Brian, JE; Hicks, KK; Kennedy, RH; Seifen, E | 1 |
| Hönig-Liedl, P; Horstrup, K; Jablonka, B; Just, M; Kochsiek, K; Walter, U | 1 |
| Cunningham, JM; Delaney, CA; Green, IC; Mabley, JG | 1 |
| Becker, AJ; Djamilian, MH; Jonas, U; Stief, CG; Truss, MC | 1 |
| Beckman, J; Crow, JP; Haddad, IY; Hu, P; Matalon, S; Ye, Y | 1 |
| Piper, HM; Schlüter, KD; Schraven, E; Weber, M | 1 |
| Arock, M; Debré, P; Dugas, B; Kilchherr, E; Kolb, JP; Mossalayi, MD; Ouaaz, F; Paul-Eugène, N | 1 |
| Ellis, JL; Fernandes, LB; Undem, BJ | 1 |
| Drescher, P; Madsen, PO; Sparwasser, C; Will, JA | 1 |
| Bonzel, T; Hasenfuss, G; Hug, J; Just, HJ; Wollschläger, H | 1 |
| Heitzer, T; Just, H; Kurz, S; Luhmann, C; Münzel, T | 1 |
| Madison, DV; Meffert, MK; Schulman, H; Schuman, EM | 1 |
| de Vernejoul, P; Vacheron, A | 1 |
| Iadecola, C; Zhang, F | 2 |
| Ferguson, JJ | 1 |
| Brüne, B; Mohr, S; Stamler, JS | 1 |
| Klatt, P; Mayer, B; Schmidt, K | 1 |
| Janigro, D; Nguyen, TS; West, GA; Winn, HR | 1 |
| Mohaupt, M; Schoecklmann, HO; Schulze-Lohoff, E; Sterzel, RB | 1 |
| Arock, M; Bécherel, PA; Debré, P; Dugas, B; Le Goff, L; Mossalayi, MD | 1 |
| Advenier, C; Naline, E; Palette-Pays, C; Varoquaux, O; Zhang, Y | 1 |
| Iadecola, C; White, JG; Zhang, F | 1 |
| Kaeffer, N; Richard, V; Thuillez, C; Tron, C | 1 |
| Andersen, TT; Bahou, WF; Goligorsky, MS; Magazine, H; Malik, AB; Tsukahara, H | 1 |
| Andersson, KE; Hedlund, H; Hedlund, P; Holmquist, F | 1 |
| Chen, J; Egberg, N; Karlberg, KE; Sylvén, C | 1 |
| Hardy, E; Horn, EH; Rubin, PC | 1 |
| Kruszyna, H; Kruszyna, R; Rochelle, LG; Smith, RP; Wang, Y; Wilcox, DE | 1 |
| Augusto, O; Gatti, RM; Radi, R | 1 |
| Becquet, F; Courtois, Y; Goureau, O | 1 |
| Clarke, GA; Gross, GJ; Pieper, GM | 1 |
| Ceppi, ED; Horton, RA; Knowles, RG; Titheradge, MA | 1 |
| Arnet, U; Ganten, D; Lüscher, TF; Noll, G; Novosel, D; Tschudi, MR | 1 |
| Fung, KP; Wu, J; Wu, TW; Zeng, LH | 1 |
| Knispel, HH; Wegner, HE | 1 |
| Eigler, A; Endres, S; Sinha, B | 1 |
| Bosnjak, ZJ; Coughlan, MG; Kampine, JP; Kenny, D; Warltier, DC | 1 |
| Bender, M; Klepzig, H; Kober, G; Sievert, H; Vallbracht, C | 1 |
| Berkenboom, G; Brékine, D; Fontaine, J; Unger, P | 1 |
| Hess, DT; Patterson, SI; Skene, JH; Smith, DS | 1 |
| de Groot, H; Ioannidis, I | 1 |
| Schrör, K; Strobach, H; Weber, AA | 1 |
| DeGraff, W; Gamson, J; Keefer, LK; Krishna, MC; Mitchell, JB; Wink, DA | 1 |
| Kubes, P | 1 |
| Arnal, JF; Michel, JB; Schott, C; Stoclet, JC | 1 |
| Degré, S; Gaertner, W; Ostrowski, J; Sennesael, J; Stolear, JC; Unger, P; Verbeelen, D; von Hattingberg, HM | 1 |
| Jones, KA; Katusić, ZS; Lorenz, RR; Sieck, GC; Warner, DO | 1 |
| Dubois-Randé, JL; Dupouy, P; Gallot, D; Geschwind, HJ; Pelle, G | 1 |
| Champsaur, G; Estanove, S; Girard, C; Laroux, MC; Neidecker, J | 1 |
| Flammer, J; Lüscher, TF; Meyer, P | 1 |
| Becker, AJ; Forssmann, WG; Jonas, U; Kircher, M; Krah, H; Mayer, B; Meyer, MF; Staubesand, J; Stief, CG; Taher, A | 1 |
| Busse, R; Hecker, M; Mordvintcev, PI; Mülsch, A; Vanin, AF | 1 |
| Cosentino, F; Katusić, ZS; Sill, JC | 1 |
| Kubes, P; Payne, D | 1 |
| Chen, HS; Choi, YB; Lei, SZ; Lipton, SA; Loscalzo, J; Pan, ZH; Singel, DJ; Stamler, JS; Sucher, NJ | 1 |
| Brenner, HH; Etzkorn, K; Kolb, H; Kolb-Bachofen, V; Kröncke, KD; Noack, EA; Rodriguez, ML | 1 |
| Kankaanranta, H; Metsä-Ketelä, T; Moilanen, E; Vapaatalo, H; Vuorinen, P | 1 |
| Kurtz, A; Schricker, K | 1 |
| Andersson, KE; Fridstrand, M; Hedlund, H; Holmquist, F | 1 |
| Bath, PM | 1 |
| de Groot, H; Hegi, U; Sies, H | 1 |
| Adams, GE; Stratford, IJ; Szabo, C; Thiemermann, C; Vane, JR; Wood, PJ | 1 |
| Hiraoka, M; Muramatsu, I; Sudo, M; Tsuchida, S | 1 |
| Galluser, M; Raul, F; Schleiffer, R | 1 |
| Branka, JE; Jarry, A; Laboisse, CL; Vallette, G | 1 |
| Grünberg, B; Kratzer, MA; Lorenz, R; Negrescu, EV; Siess, W | 1 |
| Blanc, T; Kaeffer, N; Richard, V; Thuillez, C; Tron, C | 1 |
| Bouton, C; Drapier, JC; Raveau, M | 1 |
| Boeckxstaens, GE; De Man, JG; De Winter, BY; Herman, AG; Moreels, TG; Pelckmans, PA | 1 |
| Holzer, P; Jocic, M; Peskar, BA | 1 |
| Cobbe, SM; Kane, KA; Martynyuk, AE; Rankin, AC | 1 |
| Chaudhuri, G; Chopra, M; Gryglewski, R; Ignarro, LJ; Radziszewski, W; Zembowicz, A | 1 |
| Brien, JF; Jimmo, SL; Marks, GS; McLaughlin, BE; Nakatsu, K; Poklewska-Koziell, M | 1 |
| Dikshit, M; Shukla, A; Srimal, RC | 1 |
| Darley-Usmar, V; Knowles, RG; Lizasoain, I; Moncada, S; Moro, MA | 1 |
| Lapetina, EG; Reep, BR | 1 |
| Aeberhard, E; Chaudhuri, G; Farias-Eisner, R; Fukuto, JM | 1 |
| De Caterina, R; Hong, YH; Liao, JK; Libby, P; Peng, HB; Shin, WS | 1 |
| Balligand, JL; Han, X; Kelly, RA; Kobzik, L; Smith, TW | 1 |
| Currie, MG; Mollace, V; Salvemini, D | 1 |
| Brutsaert, DL; Mohan, P; Paulus, WJ; Sys, SU | 1 |
| Constantine-Paton, M; Rentería, RC | 1 |
| Amemiya, H; Enosawa, S; Kakefuda, T; Kanashiro, M; Suzuki, S | 1 |
| Barnett, C; Biffl, WL; Moore, EE; Moore, FA | 1 |
| Ballejo, G; De Oliveira, RB; Martins, SL | 1 |
| Behar-Cohen, FF; Courtois, Y; D'Hermies, F; Goureau, O | 1 |
| Buurman, WA; Friedman, G; Preiser, JC; Rogiers, P; Spapen, H; Vincent, JL; Zhang, H | 1 |
| Kawanishi, M | 1 |
| Andersson, KE; Persson, K; Waldeck, K | 1 |
| Sadoff, JD; Scholz, PM; Tse, J; Weiss, HR | 1 |
| Hausmann, D; Jost, S; Lichtlen, PR; Lippolt, P; Sturm, M | 1 |
| Pieper, GM; Tseng, LF; Xu, JY | 1 |
| Bucher, B; Butt, E; Genieser, HG; Huggins, JP; Pöhler, D | 1 |
| Palluy, O; Rigaud, M | 1 |
| Fu, SX; Li, YS; Lu, SC; Ren, DC; Wang, FX; Yang, XP | 1 |
| Cunningham, JM; Delaney, CA; Eizirik, DL; Green, IC; Green, MH; Hellerström, C; Pipeleers, DG; Thorpe, JR | 1 |
| Gonzalez, MC; Linares, JD; Llorente, E; Santos, M | 1 |
| Irifune, M; Kamata, Y; Nishikawa, T; Sato, T | 1 |
| Dickens, BF; Komarov, AM; Mak, IT; Stafford, RE; Wagner, TL; Weglicki, WB | 1 |
| Adams, GE; Sansom, JM; Stratford, IJ; Szabo, C; Thiemermann, C; Vane, JR; Wood, PJ | 1 |
| Barefield, E; Crow, J; Gadilhe, T; Haddad, IY; Matalon, S; Zhu, S | 1 |
| Elliott, SJ | 1 |
| Kennedy, RH; Seifen, E; Temma, K; Wyeth, RP | 1 |
| Green, CJ; Hidalgo, A; Mohammed, S; Motterlini, R; Sammut, I; Shah, KA; Srai, K | 1 |
| Foresti, R; Intaglietta, M; Motterlini, R; Winslow, RM | 1 |
| Garcia-Dorado, D; Jakob, G; Piper, HM; Ruiz-Meana, M; Schlüter, KD | 1 |
| Klän, R; Knispel, HH; Miller, K; Wegner, HE | 1 |
| Fandrey, J; Hoffmann, G; Schobersberger, W | 1 |
| Christodoulou, D; Cook, JA; Ford, PC; Grisham, MB; Krishna, MC; Kudo, S; Miles, A; Murugesan, M; Wink, DA | 1 |
| Brüne, B; Messmer, UK | 1 |
| Baux, G; Fossier, P; Mothet, JP; Tauc, L | 1 |
| Key, BJ; Lovick, TA | 1 |
| Ames, BN; Liu, J; Mori, A; Shigenaga, MK; Yan, LJ | 1 |
| Haddad, IY; Matalon, S; Zhu, S | 1 |
| Pehl, U; Schmid, HA | 1 |
| Brien, JF; Hussain, AS; Marks, GS; Nakatsu, K | 1 |
| Giddings, JC; Sasaki, Y; Seki, J; Yamamoto, J | 1 |
| Bidouard, JP; Bloch, G; Jacquemin, C; Janiak, P; Menasché, P; Perrault, LP; Vanhoutte, PM; Vilaine, JP; Villeneuve, N; Wassef, M | 1 |
| Bassenge, E; Cereda, R; Fink, B | 1 |
| Boulanger, CM; Desta, B; Nakashima, M; Vanhoutte, PM | 1 |
| Arkonac, BM; Kersten, JR; Nijhawan, N; Warltier, DC; Wynsen, JC | 1 |
| François, A; Henry, JP; Kaeffer, N; Lallemand, F; Richard, V; Thuillez, C | 1 |
| Hebeiss, K; Kilbinger, H | 1 |
| Gladis-Villanueva, M; Schrör, K | 1 |
| Czarnowska, E; Karwatowska-Prokopczuk, E | 1 |
| Ebihara, Y; Karmazyn, M | 1 |
| Berrino, L; D'Amico, M; De Novellis, V; Maione, S; Rossi, F; Vitagliano, S | 1 |
| Heinemann, A; Stauber, RE | 1 |
| Farrukh, IS; Hoidal, JR; Peng, W | 1 |
| Grisham, MB; Milligan, SA; Owens, MW | 1 |
| Bartrons, R; Dalmau, M; Gil, J; Joaquin, M; Nakamura, T | 1 |
| Campbell, DL; Stamler, JS; Strauss, HC | 1 |
| Andrade, J; Bedoya, FJ; Conde, J; Conde, M; Monteseirín, J; Ramírez, R; Sobrino, F | 1 |
| Sjöholm, A | 1 |
| Allescher, HD; Huber, A; Kurjak, M; Schusdziarra, V; Trudrung, P | 1 |
| Falke, KJ; Gerlach, H; Gerlach, M; Keh, D; Kerner, T; Kürer, I; Seiler, S | 1 |
| Lee, JJ; Olmos, L; Vanhoutte, PM | 1 |
| Darley-Usmar, VM; Graham, A; O'Leary, VJ; Stone, D | 1 |
| Hamazaki, K; Horton, AA; Inai, Y; Inoue, M; Nakahara, H; Takehara, Y; Utsumi, K; Yabuki, M; Yoshioka, T | 1 |
| Ikeda, M; Ikeda, U; Kano, S; Minota, S; Shimada, K; Takahashi, M | 1 |
| Kapás, L; Krueger, JM | 1 |
| Boev, KK; Petkov, GV | 2 |
| Balazy, M; Barton, A; Bednar, MM; Bingham, J; Booth, C; Fuller, SP; Golding, L; Gross, CE; Murphy, M | 1 |
| Sontheimer, H; Ye, ZC | 1 |
| Ballmaier, D; Briviba, K; Epe, B; Roussyn, I; Sies, H | 1 |
| Barja-Fidalgo, C; Cunha, FQ; Ferreira, SH; Fierro, IM | 1 |
| Canning, BJ; Dey, RD; Karakousis, PC; Undem, BJ | 1 |
| Adler, KB; Akley, NJ; Fischer, BM; Li, C; Rochelle, LG; Wright, DT | 1 |
| Charansonney, O; Delonca, J; Giraud, T; Lennuyeux, E | 1 |
| Nurminen, ML; Vapaatalo, H | 1 |
| Fischer, H; Lamberti, C; Philippu, A; Prast, H; Tran, MH | 1 |
| Brock, GB; Lue, TF; Martinez-Piñeiro, L; von Heyden, B | 1 |
| Darley-Usmar, VM; Diczfalusy, U; Dzeletovic, S; Patel, RP; Wilson, MT | 1 |
| Järvinen, TA; Järvinen, TL; Moilanen, E; Moilanen, T | 1 |
| Garland, CJ; Hurrell, A; Jeremy, JY; Plane, F | 1 |
| Crews, BC; Landino, LM; Marnett, LJ; Morrow, JD; Timmons, MD | 1 |
| Colasanti, M; Lauro, GM; Merante, A; Musci, G; Venturini, G | 1 |
| Grabau, CE; Hunter, LW; Rorie, DK; Tyce, GM; Ward, LE | 1 |
| Bassand, JP; Battaglia, S; Béard, T; Bertrand, B; Bertrand, ME; Boschat, J; Coste, P; Crochet, PD; Desveaux, B; Drobinski, G; Dubois-Randé, JL; Finet, G; Giraud, T; Grollier, G; Juillière, Y; Juliard, JM; Lablanche, JM; Le Breton, H; Leclercq, F; Letac, B; Livarek, B; Lusson, JR; Metzger, JP; Quiret, JC; Virot, P | 1 |
| Li, L; Paakkari, I; Redemann, B; Vaali, K; Vapaatalo, H | 1 |
| Becker, AJ; Jonas, U; Machtens, S; Stief, CG; Truss, MC; Uckert, S | 1 |
| Kilbinger, H | 1 |
| Lucius, R; Sievers, J | 2 |
| Boss, GR; Pascual, FE; Pilz, RB; Suhasini, M | 1 |
| Bassenge, E; Dikalov, S; Skatchkov, M | 1 |
| Avila, MA; Boscá, L; Casado, M; Martin-Sanz, P; Martínez-Chantar, ML; Mato, JM; Mingorance, J | 1 |
| Adams, MR; Celermajer, DS; Hailstones, D; Jessup, W | 1 |
| Cermak, R; Forssmann, WG; Hirsch, JR; Kleta, R; Kruhøffer, M; Kuhn, M; Schafer, JA; Schlatter, E; Sun, D | 1 |
| Cambar, J; Potier, M; Winicki, J | 1 |
| Hempel, A; Hölschermann, H; Noll, T; Piper, HM | 1 |
| Fujiwara, Y; Gambone, LM; Murray, PA | 1 |
| Katusic, ZS; Kinoshita, H | 2 |
| Alm, P; Andersson, KE; Johansson, K; Larsson, B; Persson, K | 1 |
| Funayama, H; Ikeda, U; Kano, S; Masuyama, J; Shimada, K; Takahashi, M | 1 |
| Chen, AF; Crotty, TB; Katusic, ZS; Kinoshita, H; O'Brien, T; Pompili, VJ; Spector, DJ; Tsutsui, M | 1 |
| Haussmann, HJ; Muller, T; Schepers, G | 1 |
| Naim, KL; Rabindranauth, P; Sadoff, JD; Scholz, PM; Tse, J; Weiss, HR | 1 |
| Damoulis, PD; Hauschka, PV | 1 |
| Chwalisz, K; Garfield, RE; Jain, V; Liao, QP; Saade, GR; Vedernikov, YP | 1 |
| Asghari, V; Wang, JF; Woods, CM; Young, LT | 1 |
| Abate, A; Oberle, S; Schröder, H; Ullrich, T | 1 |
| Cook, DI; Poronnik, P; Tuch, BE; Weinhaus, AJ | 1 |
| Metsä-Ketelä, T; Moilanen, E; Vilpo, JA; Vilpo, LM; Vuorinen, P | 1 |
| Hoglen, NC; Liebler, DC; Sipes, IG; Waller, SC | 1 |
| Fujioka, M; Isaka, N; Ito, M; Miyahara, M; Nakano, T; Nishikawa, M; Shiku, H | 1 |
| Christodoulides, N; Durante, W; Kroll, MH; Peyton, KJ; Schafer, AI | 1 |
| Hemmens, B; Leopold, E; Mayer, B; Pfeiffer, S; Schmidt, K; Werner, ER | 1 |
| Fisher, D; Ischiropoulos, H; Kang, M; Thom, SR | 1 |
| Bauer, H; Frölich, JC; Jung, T; Neumann, C; Stichtenoth, DO; Tsikas, D | 1 |
| Iadecola, C; Yang, G | 1 |
| Brady, T; D'Ambrosio, SM; Oberyszyn, TM; Robertson, FM; Ross, MS | 1 |
| Holm, P; Kankaanranta, H; Knowles, RG; Kosonen, O; Moilanen, E; Vuorinen, P | 1 |
| Fouyas, IP; Kelly, PA; Ritchie, IM; Whittle, IR | 1 |
| Fandrey, J; Kiprianova, I; Schwab, S; Spranger, M | 1 |
| Ikeda, M; Kano, S; Minota, S | 1 |
| Antoine, MH; Herchuelz, A; Hermann, M; Lebrun, P; Ouedraogo, R; Segooris, J | 1 |
| Katusic, ZS; Onoue, H | 2 |
| Ohshima, H; Yoshie, Y | 1 |
| Jonas, U; Schultheiss, D; Stief, CG; Truss, MC | 1 |
| Clark, SC; Dark, JH; Kirby, JA | 1 |
| Baux, G; Fossier, P; Mothet, JP; Schirar, A; Tauc, L | 1 |
| Nishizawa, S; Ryu, H; Uemura, K; Yamamoto, S; Yokoyama, T | 1 |
| Brown, HF; Casadei, B; Lei, M; Musialek, P; Paterson, DJ | 1 |
| Borderie, D; Calmus, Y; Houssin, D; Sogni, P; Soubrane, O; Zhang, B | 1 |
| Cuthbertson, BH; Galley, HF; Webster, NR | 2 |
| Anderson, DR; Haefliger, IO | 1 |
| Dietl, P; Friedrich, F; Hoffmann, G; Schobersberger, W; Völkl, H | 1 |
| Kinoshita, M; Liu, Q; Matsumoto, T; Nakae, I; Omura, T; Takahashi, M; Takaoka, A | 1 |
| Asahi, M; Fujii, J; Hori, M; Kuzuya, T; Shimonishi, Y; Takao, T; Taniguchi, N | 1 |
| Boscá, L; Dallaporta, B; Hirsch, T; Hortelano, S; Kroemer, G; Marzo, I; Susin, SA; Zamzami, N | 1 |
| Salt, TE; Shaw, PJ | 1 |
| Bouton, C; Drapier, JC; Hirling, H | 1 |
| Cunningham, JM; Green, IC; Mabley, JG | 1 |
| Cayabyab, FS; Daniel, EE; deBruin, H; Jiménez, M; Vergara, P | 1 |
| Invernizzi, P; O'Connor, M; Salzman, AL; Setchell, KD; Szabó, C; Ueta, I | 1 |
| Deka, DK; Mishra, SK; Raviprakash, V | 1 |
| Demirakça, S; Dittrich, K; Dötsch, J; Haberberger, R; Hänze, J; Rascher, W | 1 |
| Behrendt, J; Beste, O; Dittrich, K; Dötsch, J; Hänze, J; Rascher, W; Weber, WM | 1 |
| Kondo, H; Niki, E; Takahashi, M | 1 |
| Ade, P; Balduzzi, M; Guastadisegni, C; Levi, G; Minghetti, L; Nicolini, A; Polazzi, E | 1 |
| Danziger, RS; Pensler, JM; Zuckerbraun, BS | 1 |
| Blasig, IE; Haseloff, RF; Kirilyuk, IA; Rubanyi, GM; Zöllner, S | 1 |
| Barkin, M; Barnett, CC; Moore, EE; Offner, PJ; Partrick, DA; Silliman, CC | 1 |
| Fink, MP; Menconi, MJ; Unno, N | 1 |
| Karmazyn, M; Sims, SM; Thomas, GP | 1 |
| Azam, M; Danziger, RS; Gupta, G; Yang, L | 1 |
| Hosoki, R; Kimura, H; Matsuki, N | 1 |
| Murakami, Y; Okuma, Y; Osumi, Y; Yokotani, K | 2 |
| Burger, W; Hartmann, A; Mazzilli, N; Olbrich, HG; Peter-Wolf, W; Schacherer, C; Weis, M; Wiemer, J | 1 |
| Fisher, PW; Huang, YC; Nozik-Grayck, E; Piantadosi, CA | 1 |
| Merhi, Y; Provost, P; Tremblay, J | 1 |
| Nishizawa, S; Uemura, K; Yamamoto, S; Yokoyama, T | 1 |
| Kaeffer, N; Richard, V; Thuillez, C | 1 |
| Cabral, A; Peny, MO; Preiser, JC; Rogiers, P; Smail, N; Vincent, JL; Zhang, H | 1 |
| Greenlees, C; Martorana, PA; Wadsworth, RM; Wainwright, CL | 1 |
| Brorson, JR; Zhang, H | 1 |
| D'Souza, SW; Lees, RD; Slater, P | 1 |
| Janssen, YM; Matalon, S; Mossman, BT | 1 |
| Bhatnagar, A; Chandra, A; Petrash, JM; Srivastava, S; Srivastava, SK | 1 |
| Alanko, J; Lähteenmäki, TA; Sievi, E; Vapaatalo, H; Vuorinen, P | 1 |
| Fasching, CE; Hayakawa, H; Jaimes, E; Janoff, EN; Kenner, JR; Raij, L; Taylor, DN | 1 |
| Billiar, TR; Kim, YM; Li, J; Talanian, RV | 1 |
| Cullen, VC; Eustace, NP; Keenan, AK | 1 |
| Anggård, EE; Carrier, MJ; Quine, LA | 1 |
| Clark, SC; Dark, JH; Kirby, JA; Shenton, BK | 1 |
| Bracht, C; Kim, JH; Kiowski, W; Sütsch, G | 1 |
| Becherini, L; Benvenuti, S; Brandi, ML; Mancini, L | 1 |
| Aquirre, L; Camarasa, J; Camins, A; Escubedo, E; Gabriel, C; Pallàs, M; Sureda, FX | 1 |
| Amin, N; Pearce, B | 1 |
| Drescher, P; Madsen, PO | 1 |
| Hayakawa, A; Hayashi, S; Katayama, A; Kobayashi, T; Koike, C; Nagasaka, T; Namii, Y; Negita, M; Tachi, Y; Tajiri, H; Takagi, H; Yokoyama, I | 1 |
| Corriveau, CC; Danner, RL; Madara, PJ; Tropea, MM; Van Dervort, AL; Wesley, RA | 1 |
| Eu, JP; Meissner, G; Stamler, JS; Xu, L | 1 |
| Inagaki, N; Musoh, K; Nagai, H; Nakamura, N; Ueda, Y | 1 |
| Gryglewski, RJ; Marcinkiewicz, E; Michalska, Z; Robak, J | 1 |
| Oberle, S; Polte, T; Schröder, H | 1 |
| Oberle, S; Schröder, H | 1 |
| Angaut-Petit, D; Blanchard, B; Ducrocq, C; Faille, L; Meunier, FA; Morot Gaudry-Talarmain, Y; Moulian, N | 1 |
| Briot, F; Dalloz, F; Lecour, S; Maupoil, V; Rochette, L | 1 |
| Eriksson, S; Gerstberger, R; Hjelmqvist, H; Keil, R | 1 |
| Cantabrana, B; Hidalgo, A; Menéndez Antolin, L; Pérez Vallina, JR; Sánchez, M | 1 |
| Beaufils, P; Delonca, J; Dupuis, B; Giraud, T; Haïat, R; Théry, C | 1 |
| Gow, AJ; Ischiropoulos, H; Thom, SR | 1 |
| Christopher, TA; Ischiropoulos, H; Liu, GL; Lopez, BL; Ma, XL | 1 |
| Nishio, E; Watanabe, Y | 1 |
| Hokari, R; Ishii, H; Ishikawa, H; Kitajima, M; Kurose, I; Miura, S; Otani, Y; Shimazu, M; Wakabayashi, G; Yoshida, M | 1 |
| Demontis, MP; Emanueli, C; Madeddu, P; Varoni, MV; Volpe, AR | 1 |
| Chang, ES; Graubard, K; Scholz, NL; Truman, JW | 1 |
| Alm, P; Andersson, KE; Persson, K; Uvelius, B | 1 |
| Das, PK; Gerzer, R; Ivanova, K; Le Poole, IC; Westerhof, W | 1 |
| Higuchi, S; Nakasone, C; Noguchi, K; Shigenobu, K; Shijuku, T; Takahashi, K; Tanaka, H; Tanaka, Y | 1 |
| Denenberg, AG; Kennedy, M; Salzman, AL; Szabó, C | 1 |
| Brandi, ML; MacIntyre, I; Mancini, L; Moradi-Bidhendi, N | 1 |
| Gauer, S; Pröls, F; Schoecklmann, HO; Sterzel, RB; Yao, J | 1 |
| Chen, KH; Horton, JK; Singhal, RK; Sobol, RW; Srivastava, DK; Van Houten, B; Wilson, SH; Yakes, FM | 1 |
| Bode-Böger, SM; Böger, RH; Frölich, JC; Galland, A | 1 |
| Burnstein, A; Rootman, DS; Wu, J; Wu, TW; Zeng, LH | 1 |
| Hagino, Y; Matsui, S; Nomura, H; Nomura, T; Ohtsuki, M; Sumi-Ichinose, C | 1 |
| Elmedal, B; Hernández, M; Mulvany, MJ; Simonsen, U | 1 |
| Desaki, J; Maeda, N; Matsuda, S; Peng, H; Sakanaka, M; Sudo, S; Tanaka, J; Wen, TC; Zhang, B | 1 |
| Lang, U; Vischer, UM; Wollheim, CB | 1 |
| Cunningham, JM; Delaney, CA; Green, IC; Green, MH | 1 |
| Akita, H; Hirata, K; Kawashima, S; Rikitake, Y; Yokoyama, M | 1 |
| Aguirre, T; Cassiman, JJ; Goetschalckx, K; Mathijs, G; Robberecht, W; Tilkin, P; Van Den Bosch, L | 1 |
| Blasig, IE; Davies, KJ; Grune, T; Haseloff, R; Roloff, B; Sitte, N | 1 |
| de Groot, H; Kirsch, M; Lomonosova, EE; Rauen, U | 1 |
| Branka, JE; Dreno, B; Jarry, A; Laboisse, CL; Sainte-Marie, I; Tenaud, I; Vallette, G | 1 |
| Brunet, A; Catuli, D; Devynck, MA; Le Feuvre, C; Le Quan Sang, KH; Metzger, JP; Vacheron, A | 1 |
| Cohen, RA; Garland, CJ; Jeremy, JY; Plane, F; Wiley, KE | 1 |
| de Groot, H; Kirsch, M; Korth, HG; Lomonosova, EE; Sustmann, R | 1 |
| Davies, MJ; Stocker, R; Thomas, SR | 1 |
| Lee, EH; Tsai, MJ | 1 |
| Gong, GX; Scholz, PM; Tse, J; Weiss, HR | 1 |
| Maruyama, W; Naoi, M; Takahashi, T | 1 |
| Hogg, N; Kalyanaraman, B; Konorev, EA | 1 |
| DuVall, MD; Fuller, CM; Matalon, S; Zhu, S | 1 |
| Holm, P; Kankaanranta, H; Metsä-Ketelä, T; Moilanen, E | 1 |
| Wolkow, PP | 1 |
| Ackermann, A; Fernández-Alfonso, MS; González, C; Ortega, T; Paul, M; Sánchez de Rojas, R | 1 |
| Allescher, HD; Franck, H; Puschmann, A; Schusdziarra, V; Storr, M | 1 |
| Li, L; Paakkari, I; Vaali, K; Vapaatalo, H | 1 |
| Howlett, A; Klein, C; Najafi, L; Shipley, S; Tao, YP | 1 |
| Koesling, D; Mayer, B; Pfeiffer, S; Schmidt, K; Schrammel, A | 1 |
| Cuajungco, MP; Lees, GJ | 1 |
| González, MC; Llorente, E | 1 |
| Ahmed, U; Conant, K; Major, EO; Schwartz, JP | 1 |
| Buvat, J; Lemaire, A | 1 |
| Garland, CJ; Högestätt, ED; Paulsson, M; Plane, F; Zygmunt, PM | 1 |
| Balogh, GE; Papp, JG; Pataricza, J; Penke, B | 1 |
| Aymerich, MS; de Castro, P; González, A; López-Moratalla, N; López-Zabalza, MJ; Pío, R; Santiago, E | 1 |
| Bernassola, F; Catani, MV; Melino, G; Rossi, A | 1 |
| Iwamuro, Y; Komuro, T; Masaki, T; Minowa, T; Miwa, S; Ninomiya, H; Okamoto, Y; Sawamura, T; Zhang, XF | 1 |
| Kelly, PA; Malcolm, GP; Ritchie, I; Swaroop, GR; Whittle, IR | 1 |
| Cambria, RA; Freischlag, JA; Johnson, D; Kelly, H; Lesniak, R; Mudaliar, JH; Seabrook, MD; Towne, JB | 2 |
| Boev, KK; Petkov, GV; Spassov, GD | 1 |
| Kane, KA; Karamsetty, MR; Wadsworth, RM | 1 |
| Fein, A; Tertyshnikova, S; Yan, X | 1 |
| Abderrahmane, A; Cadieux, A; Dumoulin, M; Garon, J; Rousseau, E; Salvail, D | 1 |
| Fujino, MA; Hosoda, K; Owyang, C; Takahashi, T | 1 |
| Helton, ES; Jackson, RM; Parish, G | 1 |
| Bocca, AL; Campanelli, AP; Cunha, FQ; Figueiredo, F; Furlanetto, AB; Hayashi, EE; Pinheiro, AG | 1 |
| Asano, Y; Bucci, E; Koehler, RC; Traystman, RJ; Ulatowski, JA | 1 |
| LaPointe, MC; Marsh, JD; Ritchie, RH; Schiebinger, RJ | 1 |
| Allescher, HD; Franck, H; Huber, A; Ruth, P; Schusdziarra, V; Storr, M; Trudrung, P | 1 |
| Mayer, B; Pfeiffer, S | 1 |
| Lynch, JW | 1 |
| Kim, WK; Ko, KH | 1 |
| Lähteenmäki, T; Sievi, E; Vapaatalo, H | 1 |
| Brüne, B; Callsen, D; Pfeilschifter, J | 1 |
| Blaylock, MG; Cuthbertson, BH; Ferguson, NR; Galley, HF; Webster, NR | 1 |
| Hinz, B; Schröder, H | 2 |
| Aguirre, DE; Fink, MP; Menconi, MJ; Smith, M; Unno, N | 1 |
| Asada, S; Fukuda, K; Oh, M; Tanaka, S; Yasuda, Y | 1 |
| de Vente, J; Grillner, S; Hökfelt, T; Steinbusch, H; Xu, ZQ | 1 |
| Fernández-Tomé, P; Leza, JC; Lizasoain, I; Lorenzo, P; Moro, MA | 1 |
| Aimar, P; Carmignoto, G; Merighi, A; Pasti, L | 1 |
| Choi, JJ; Kim, WK | 1 |
| Alm, P; Andersson, KE; Persson, K; Werkström, V | 1 |
| Miyakoshi, M; Murayama, T; Naganuma, T; Nomura, Y | 1 |
| Hars, B | 1 |
| Hogg, N; Joseph, J; Kalyanaraman, B; Konorev, E; Singh, RJ | 1 |
| Maiese, K; Vincent, AM | 2 |
| Anderson, RE; Coert, BA; Meyer, FB | 2 |
| Keilhoff, G; Reiser, M; Schild, L; Wolf, G | 1 |
| Ishii, M; Momose, K; Shimizu, S; Yamamoto, T | 1 |
| Clark, SC; Dark, JH; Flecknell, PA; Roughan, J; Sudarshan, C | 1 |
| Chataigneau, T; Duhault, J; Félétou, M; Fishman, MC; Huang, PL; Vanhoutte, PM | 1 |
| Aizenman, E; Potthoff, WK | 1 |
| Buus, NH; Mulvany, MJ; Simonsen, U; Wadsworth, RM | 1 |
| Goss, SP; Hogg, N; Kalyanaraman, B | 1 |
| Exner, M; Gmeiner, B; Held, I; Hermann, M; Hofbauer, R; Kapiotis, S; Seelos, C | 1 |
| Crozatier, B; Guenoun, T; Laplace, M; Montagne, O; Roser, F | 1 |
| Frosini, M; Fusi, F; Sgaragli, GP; Valoti, M | 1 |
| Cui, M; Lin, Q; Peng, YB; Willis, WD; Wu, J | 2 |
| Galloway, MP; West, AR | 1 |
| Hiramoto, K; Kikugawa, K; Tomiyama, S | 1 |
| Hirata, K; Kanazawa, H; Okamoto, T; Shiraishi, S; Yoshikawa, J | 1 |
| Hatori, M; Kamijo, R; Nagumo, M; Sumitani, K; Takizawa, K; Toyoshima, T | 1 |
| Regoli, F; Winston, GW | 1 |
| Archer, DC; Blantz, RC; Ishizuka, S; Kelly, CJ; Satriano, J | 1 |
| Nuñez, G; Ogawa, S; Tamatani, M; Tohyama, M | 1 |
| Capone, F; Machelska, H; Pavone, F; Przewłocka, B | 1 |
| Niki, E; Noguchi, N; Shi, H; Xu, Y | 1 |
| Boldyrev, AA; Carpenter, DO; Johnson, P; Tan, Y; Wei, Y | 1 |
| Fiore, SA; Homer, KL; Wanstall, JC | 1 |
| Janssen-Heininger, YM; Macara, I; Mossman, BT | 1 |
| Roberts, LJ; van der Veen, RC | 1 |
| Rehder, V; Van Wagenen, S | 2 |
| Han, C; Lautt, WW; Ming, Z | 2 |
| Danielou, E; Kaeffer, N; Richard, V; Thuillez, C | 1 |
| Feld, S; Smalling, RW | 1 |
| Courtois, Y; Goureau, O; Régnier-Ricard, F | 1 |
| Chow, SM; Lau, HY | 1 |
| Law, A; Wu, J; Wu, TW; Zeng, LH | 1 |
| Edelstein, CL; Gengaro, PE; Ling, H; Nemenoff, RA; Schrier, RW; Wangsiripaisan, A | 1 |
| Blin, D; Chavanon, O; Cracowski, JL; Durand, M; Hacini, R; Noirclerc, M; Stanke, F | 1 |
| Celan, I; Chazotte, L; Mower, HF; Ohshima, H; Pignatelli, B | 1 |
| Choi, JJ; Kim, WK; Ko, KH; Seo, DO | 1 |
| Charles, SL; Salt, TE; Shaw, PJ | 1 |
| Bömmel, HM; Möller, M; Schmidt, HH; Stopper, H | 1 |
| Chesnais, JM; Fischmeister, R; Méry, PF | 2 |
| Immenschuh, S; Iwahara, S; Ramadori, G; Stritzke, J | 1 |
| Levine, RL; Moss, J; Rivera-Nieves, J; Thompson, WC | 1 |
| Maeda, S; Saeki, M | 1 |
| Alves-Do-Prado, W; Ambiel, CR; Silva, HM | 1 |
| Kim, HS; Kim, SH; Son, YR | 1 |
| Chen, SJ; Wu, CC; Yen, MH | 1 |
| Kawanishi, S; Oikawa, S | 1 |
| Lautt, WW; Sadri, P | 1 |
| Maiese, K; TenBroeke, M; Vincent, AM | 1 |
| Aitchison, KA; Coker, SJ | 1 |
| Fujita, H; Hara, E; Nakayama, M; Shibahara, S; Shirato, K; Takahashi, K; Takeda, K; Yoshizawa, M | 1 |
| Grisham, MB; Koyama, S; Robbins, RA; Sato, E; Simpson, KL | 3 |
| Lenzen, S; Lortz, S; Munday, R; Tiedge, M | 1 |
| Anderson, RL; Hurley, JV; Lepore, DA; Morrison, WA; Stewart, AG; Tomasi, A | 1 |
| de Gimeno, MA; Faletti, A; Pérez Martínez, S; Perotti, C | 1 |
| Callahan, LA; DiMarco, A; Nethery, D; Nosek, TM; Stofan, D; Supinski, G | 1 |
| Chénais, B; Jeannesson, P; Molle, I | 1 |
| de Groot, H; Kirsch, M | 2 |
| Kim, CK; Lee, S; Rivier, C | 1 |
| Milstone, DS; Mortensen, RM; Sowell, MO; Vassilev, PM; Ye, C | 1 |
| Adam, L; Bouvier, M; Jones, TL | 1 |
| Annala, K; Asmawi, MZ; Kankaanranta, H; Moilanen, E; Rahkonen, P | 1 |
| Iwase, M; Nagumo, M; Ohashi, M | 1 |
| Beckman, JS; Crow, JP; MacMillan-Crow, LA; Takakura, K | 1 |
| Akiyama, K; Aoyagi, K; Hirayama, A; Koyama, A; Nagase, S; Narita, M; Ohba, S; Shahrzad, S; Takemura, K; Tomida, C | 1 |
| Joseph, JA; Wang, H | 1 |
| Ding, Y; Maines, MD; McCoubrey, WK | 1 |
| Isobe, K; Maruyama, W; Naoi, M; Oh-hashi, K; Takahashi, T; Yi, H | 1 |
| Deeb, RS; Hajjar, DP; Upmacis, RK | 1 |
| Morioka, N; Okatani, Y; Wakatsuki, A; Watanabe, K | 1 |
| Campagnolo, C; Claveau, D; Li, C; Ouellet, M; Percival, MD | 1 |
| Kankaanranta, H; Kosonen, O; Malo-Ranta, U; Moilanen, E | 1 |
| Liu, L; Tewari, RP; Williamson, PR | 1 |
| Ishihara, K; Maeda, N; Sakanaka, M; Tanaka, J; Toku, K; Zhang, B | 1 |
| Briski, KP | 1 |
| Baux, G; Chaubourt, E; De La Porte, S; Fossier, P; Israël, M; Leprince, C | 1 |
| Cheng, S; Rehder, V; Van Wagenen, S | 1 |
| Adding, LC; Agvald, P; Gustafsson, LE; Persson, MG | 1 |
| Côrtes, SF; Freitas, MR; Lemos, VS; Lino, YD; Muller, B; Queiroga, CE | 1 |
| Ascenzi, P; Colasanti, M; Gradoni, L; Salvati, L; Venturini, G | 1 |
| Elstner, EF; Schneider, D | 2 |
| Gelpi, E; Gimeno, M; Gómez, G; González, E; Jawerbaum, A; Peralta, C; Pustovrh, C; Roselló-Catafau, J; Sinner, D; Xaus, C | 1 |
| Gryglewski, RJ; Korbut, R; Starzyk, D | 1 |
| Hirata, K; Kanazawa, H; Yoshikawa, J | 2 |
| Bae, HR; Bae, KW; Kang, EK; Lee, SA; Park, HT; Park, JK | 1 |
| Jan, KY; Liu, F | 1 |
| Packer, L; Park, YC; Rimbach, G; Virgili, F | 1 |
| Ernst, AF; Gallo, G; Letourneau, PC; McLoon, SC | 1 |
| Baribeau, J; Berkenbosch, JW; Perreault, T | 1 |
| Balduzzi, M; Guastadisegni, C; Levi, G; Minghetti, L; Nicolini, A; Polazzi, E | 1 |
| Dick, JM; Lefebvre, RA; Timmermans, JP; Van Geldre, LA | 1 |
| Fang, L; Lin, Q; Willis, WD; Wu, J | 1 |
| Ahmad, M; Alm, P; Andersson, KE; Aszòdi, A; Fässler, R; Hedlund, P; Ny, L; Pfeifer, A | 1 |
| Hayakawa, A; Hayashi, S; Kobayashi, T; Negita, M; Ogawa, H; Takagi, H; Yokoyama, I | 1 |
| Hill, IE; MacManus, JP; Murray, C; Rasquinha, I; Richard, J | 1 |
| Amoroso, S; Annunziato, L; Catalano, A; Di Renzo, G; Montagnani, S; Secondo, A; Tortiglione, A | 1 |
| Martinez, J; Moreno, JJ; Sanchez, T | 1 |
| Frame, MD | 1 |
| Leone, RJ; Scholz, PM; Straznicka, M; Weiss, HR | 1 |
| Hayakawa, T; Hayashi, Y; Yajima, Y | 1 |
| de Oliveira, RW; Del Bel, EA; Guimarães, FS | 1 |
| Garfield, RE; Gei, A; Mayes, M; Moore, E; Saade, GR; Vedernikov, YP | 1 |
| de Jager, AD; Hundt, AF; Hundt, HK; Scanes, T; Sutherland, FC; Swart, KJ | 1 |
| Althaus, JS; Borosky, S; Carroll, RT; Galatsis, P; Hall, ED; Kopec, KK; Kumar, V | 1 |
| Gambino, A; Thomas, BJ; Wanstall, JC | 1 |
| Cox, G; Janssen, LJ; Keshavjee, S; Lu-Chao, H; Premji, M | 1 |
| Basiouny, KF; Crow, JP; Matalon, S; Zhu, S | 1 |
| Ju, C; Kim, HC; Kim, WK; Ko, KH; Oh, YK; Ryu, JR; Shin, CY; Yoon, KN | 1 |
| Abate, A; Dennery, PA; Polte, T; Schröder, H | 1 |
| Johnson, MK; Loo, G | 1 |
| Antonelli, A; Cerasi, A; Columbaro, M; Falcieri, E; Luchetti, F; Magnani, M; Papa, S | 1 |
| Bastianetto, S; Quirion, R; Zheng, WH | 1 |
| Brunet, A; Devynck, MA; Le Feuvre, C; Le Quan Sang, KH; Metzger, JP; Pham, TD; Vacheron, A | 1 |
| Chen, Q; Gole, M; Gow, AJ; Ischiropoulos, H; Lee, VM; Themistocleous, M | 1 |
| Benhamou, PY; Kerr-Conte, J; Lemarchand, P; Moriscot, C; Pattou, F; Richard, MJ | 1 |
| de Groot, H; Kirsch, M; Korth, HG; Sustmann, R | 1 |
| Komarov, AM; Mak, IT; Weglicki, WB | 1 |
| Garfield, RE; Marx, S; Saade, GR; Vedernikov, Y | 1 |
| Beukelman, CJ; Folkerts, G; Koster, AS; Muijsers, RB; Nijkamp, FP; Postma, DS; van Den Worm, E | 1 |
| Chataigneau, T; Corriu, C; Edwards, G; Félétou, M; Quignard, J; Vanhoutte, PM; Weston, AH | 1 |
| Farina, M; Franchi, AM; Gimeno, M; Ogando, D; Perez Martinez, S; Ribeiro, ML | 1 |
| Akaike, A; Asano, Y; Honda, Y; Kashii, S; Nishida, A; Sato, S; Yamauchi, T; Yasuyoshi, H; Zhang, S | 1 |
| Sokołowska, M; Srebro, Z; Wróbel, M; Włodek, L | 1 |
| Chen, JW; Eatock, RA | 1 |
| Grune, T; Rudeck, M; Sitte, N; Volk, T | 1 |
| Grosser, N; Schröder, H | 1 |
| Iversen, J; Strandgaard, S; Wang, D | 1 |
| Mayer, B; Schmidt, K | 1 |
| Lizasoain, I; Moro, MA | 1 |
| Loweth, AC; Morgan, NG | 1 |
| Nieland, LJ; Ramaekers, FC; Reutelingsperger, CP; Schutte, B; Steinbusch, HW; Terwel, D | 1 |
| Cai, L; Ingram, AJ; James, L; Ly, H; Scholey, JW; Thai, K | 1 |
| Andersson, K; Fujiwara, M; Persson, K | 1 |
| Henry, JP; Lallemand, F; Laude, K; Richard, V; Thuillez, C | 1 |
| Choi, JH; Chung, HY; Kim, KW; Kim, MS; Lee, KH; Yang, R; Yokozawa, T | 1 |
| Högestätt, ED; Petersson, J; Ryman, T | 1 |
| Byrne, L; Croft, KD; Morton, LW; Puddey, IB | 1 |
| Muriel, P; Sandoval, G | 1 |
| Akiba, J; Hikichi, T; Kado, M; Yanagiya, N; Yoshida, A | 1 |
| Kamisaki, Y; Maeda, S; Saeki, M | 2 |
| Lauritzen, M; Rubin, I; Thomsen, K | 2 |
| Lin, SH; Maiese, K; Maynard, KI; Shaw, T; Vincent, A | 1 |
| Carrillo, MC; Kitani, K; Maruyama, W; Naoi, M; Yamamoto, T; Youdim, M | 1 |
| Choi, MS; Choi, SH; Kim, KH; Kim, YG; Park, KH; Yoon, JM | 1 |
| Buckley, BJ; Whorton, AR | 1 |
| Ekelund, UE; Georgakopoulos, D; Hare, JM; Harrison, RW; Isoda, T; Kass, DA; Ozaki, M; Paolocci, N; Vandegaer, K | 1 |
| Andersson, RG; Glindell, M; Jacobsson-Strier, M; Nyhlén, K; Persson, K; Whiss, PA | 1 |
| Tiritilli, A | 1 |
| Casadei, B; Musialek, P; Paterson, DJ; Rigg, L; Terrar, DA | 1 |
| Marthan, R; Pauvert, O; Savineau, J | 1 |
| Cacho, J; Crespo, MD; Herrera, E; Klatt, P; Ramos, P | 1 |
| Delogu, MR; Desole, MS; Esposito, G; Grella, G; Miele, E; Miele, M; Migheli, R; Rocchitta, G; Serra, PA | 1 |
| Cai, L; Kang, YJ; Klein, JB | 1 |
| Jensen, MS; Nyborg, NC; Thomsen, ES | 1 |
| Aonuma, H; Nagayama, T; Takahata, M | 1 |
| Bernardet, N; Dambrine, G; Djeraba, A; Quéré, P | 1 |
| Holbrook, NJ; Klotz, LO; Schieke, SM; Sies, H | 1 |
| Deby-Dupont, G; Hans, P; Kohnen, S; Lamy, M; Mathy-Hartert, M; Mouithys-Mickalad, A | 1 |
| Gilkeson, GS; Keng, T; Privalle, CT; Weinberg, JB | 1 |
| Daiber, A; Herold, S; Namgaladze, D; Peterson, JA; Schöneich, C; Ullrich, V | 1 |
| Bing, RJ; Yamamoto, T | 1 |
| Bothwell, M; Gunther, EC; Yuen, EC | 1 |
| Anderson, RL; Hurley, JV; Lepore, DA; Morrison, WA; Stewart, AG | 1 |
| Choi, CR; Choi, IY; Chung, JH; Kim, HC; Kim, WK; Ko, KH; Lee, SJ; Nam, W; Noh, SK; Park, JS; Shin, CY; Shin, DH | 1 |
| Arnolda, LF; Llewellyn-Smith, IJ; McKitrick, DJ; Minson, JB | 1 |
| Bauer, G; Heigold, S; Herdener, M; Saran, M | 1 |
| Chang, CC; Chu, Y; Hung, CM; Jeng, LB; Lee, WC; Lin, PJ; Yu, MC | 1 |
| Hodges, GR; Ingold, KU; Marwaha, J; Paul, T | 1 |
| Camhi, SL; Koyama, S; Nelson, DK; Robbins, RA; Sato, E | 1 |
| Campos-Pérez, JJ; Ellis, AE; Secombes, CJ | 1 |
| Isobe, K; Maruyama, W; Oh-Hashi, K | 1 |
| Aoyagi, K; Cohen, BD; Hirayama, A; Iida, S; Koyama, A; Nagase, S; Narita, M; Ohba, S; Shahrzad, S; Takemura, K; Tomida, C | 1 |
| Buccafusco, JJ; Jonnala, RR | 1 |
| Brady, T; D'Ambrosio, SM; Gibson-D'Ambrosio, RE; Oberyszyn, AS; Robertson, FM | 1 |
| Arbogast, S; Bregeon, F; Darques, JL; Jammes, Y | 1 |
| Castranova, V; Kang, JL; Lee, K | 1 |
| Connelly, PW; Crandall, I; Guy, RA; Kain, KC; Maguire, GF | 1 |
| Akaike, A; Ibi, M; Kaneko, S; Katsuki, H; Kume, T; Shimazu, S; Shirakawa, H; Takenaka, C; Tomita, M | 1 |
| Flores, A; Soto, E; Vega, R | 1 |
| Blanchard, B; Ducrocq, C; Servy, C | 1 |
| Cheong, YP; Chung, YT; Kim, BR; Kim, MS; Kim, TY; Lee, KM; Oh, J; Park, R; So, HS; Son, Y | 1 |
| Douglass, LW; Ledbetter, TK; Paape, MJ | 1 |
| Eu, JP; Meissner, G; Stamler, JS; Sun, J; Xu, L | 1 |
| Dudenhausen, JW; Falke, KJ; Gerlach, H; Keh, D; Kürer, I; Woltmann, W | 1 |
| Prado, WA; Sousa, AM | 1 |
| Abdallahi, OM; Bensalem, H; De Reggi, M; Diagana, M; Gharib, B | 1 |
| Morris, R; Thippeswamy, T | 1 |
| Barbouti, A; Doulias, PT; Galaris, D; Ischiropoulos, H | 1 |
| Decking, UK; Schrader, J; Stumpe, T | 1 |
| Kizawa, Y; Kusama, T; Murakami, H; Ohuchi, N; Saito, K | 1 |
| Leong, SK; Ruan, RS; Yeoh, KH | 1 |
| Link, H; Xiao, BG; Xu, LY; Yang, JS | 1 |
| Alcón, S; Camello, PJ; Hemming, JM; Jennings, L; Mawe, GM; Morales, S; Pozo, MJ | 1 |
| De Iuri, L; Imbrogno, S; Mazza, R; Tota, B | 1 |
| Camhi, SL; Hoyt, JC; Nelson, DK; Robbins, RA; Robinson, VK; Sato, E | 1 |
| Ishii, H; Miura, S; Watanabe, N; Zeki, S | 1 |
| Ahmed, Z; Connelly, PW; Draganov, D; Emili, A; Kuksis, A; La Du, BN; Maguire, GF; Ravandi, A | 2 |
| Atorino, L; Di Meglio, S; Farina, B; Jones, R; Quesada, P | 1 |
| An, GS; Liu, NK; Nie, SH; Tang, CS; Wang, SH; Zheng, HZ | 1 |
| Fernández, G; Vidrio, H | 1 |
| Ascenzi, P; Colasanti, M; Gradoni, L; Mattu, M; Salvati, L; Scalone, A; Venturini, G | 1 |
| Blay, WM; Heintz, NH; Hemenway, DR; Janssen-Heininger, YM; Persinger, RL | 1 |
| Li, Y; Li, ZL; Xu, WX | 1 |
| Berrih-Aknin, S; Gaudry-Talarmain, YM; Moulian, N; Serraf, A; Truffault, F | 1 |
| Niki, E; Noguchi, N; Satoh, K; Takabe, W; Uchida, K; Yamada, S | 1 |
| Bach, R; Franke, RP; Jung, F; Mrowietz, C; Reuter, P | 1 |
| Choi, JW; Kim, H; Kim, W; Ko, KH; Ryu, JH; Ryu, JR; Shin, CY | 1 |
| Diez-Orejas, R; Gil, C; Molero, G; Moro, MA; Nombela, C; Sánchez-Pérez, M | 1 |
| Stojanovic, MO; Wahler, GM; Wolska, BM; Ziolo, MT | 1 |
| Feix, J; Hogg, N; Joseph, J; Kalyanaraman, B; Zhang, H | 1 |
| Kim, MS; Lee, HS; Lee, J; Lee, KM; Moon, BS; Park, R; So, HS | 1 |
| Garland, CJ; Plane, F; Sampson, LJ; Smith, JJ | 1 |
| Dawson, R; Mehta, TR | 1 |
| Kim, H; Kim, KH; Lim, JW | 1 |
| Maruyama, W; Naoi, M; Youdim, MB | 1 |
| Imai, Y; Jiang, B; Pappano, AJ | 1 |
| Edelstein, C; Gengaro, P; Lelamali, K; Schrier, RW; Wang, W | 1 |
| Fulep, E; Garfield, RE; Saade, GR; Vedernikov, Y | 1 |
| Créminon, C; Eligini, S; Habib, A; Lebret, M; Lévy-Toledano, S; Maclouf, J | 1 |
| Flores, A; Manjarrez, E; Méndez, I; Rocha, T; Rojas-Piloni, G | 1 |
| Maruyama, W; Naoi, M | 1 |
| Bian, K; Murad, F | 1 |
| Douglas, DJ; Mauk, AG; Stocker, R; Witting, PK | 1 |
| Feng, J; Peng, X; Wang, S | 1 |
| Gupta, MP; Hart, CM; Knepler, JL; Ober, MD; Patterson, C; Pavalko, F; Taher, LN | 1 |
| Fernández, E; Jiménez, M; Tanović, A | 1 |
| Assem, EK; Moulson, A; Pearce, FL; Peh, KH; Wan, BY | 1 |
| Baribeau, J; Barrington, KJ; Berkenbosch, JW; Brock, TA; Decker, ER; Perreault, T; Wu, C | 1 |
| Buxton, IL; Kaiser, RA; Malmquist, NA; Tichenor, S | 1 |
| Flores, A; Manjarrez, E; Méndez, I; Rocha, T; Rojas-Piloni, G; Vélez, D | 1 |
| Blanco, M; Felipo, V; Martínez, A; Urios, A | 1 |
| Cooke, JP; Dulak, J; Funovics, P; Guevara, I; Huk, I; Jozkowicz, A; Pachinger, O; Weidinger, F | 1 |
| Hewett, JA; Hewett, SJ; Uliasz, TF; Vidwans, AS | 1 |
| Ducrocq, C; Gaudry-Talarmain, YM; Guermonprez, L | 1 |
| Delogu, MR; Desole, MS; Esposito, G; Miele, E; Miele, M; Migheli, R; Rocchitta, G; Serra, PA | 1 |
| Assreuy, J; Sampaio de Freitas, M; Santos-Silva, MC | 1 |
| Lautt, WW; Minuk, GY; Schoen, JM; Wang, HH | 1 |
| Fu, Y; Lei, XG; Porres, JM | 1 |
| Goldstein, D; Holvoet, P; Jaworski, K; Kinard, F; Remacle, C; Schneider, YJ; Trouet, A | 1 |
| Hewett, SJ; Trackey, JL; Uliasz, TF | 1 |
| Trakranrungsie, N; Will, JA | 1 |
| Hempelmann, RG; Kruse, ML; Mehdorn, HM; Seebeck, J; Ziegler, A | 1 |
| Bartels, W; Boissel, JP; Buerke, M; Darius, H; Grosser, T; Ibe, W; Lindemann, S; Meyer, J | 1 |
| Bridges, CC; El-Sherbeny, A; Ganapathy, V; Ola, MS; Prasad, PD; Smith, SB | 1 |
| Heimann, A; Kempski, O; Tuettenberg, J | 1 |
| Antonietti, T; Barritault, L; Le Feuvre, C; Maunoury, C; Sébahoun, S | 1 |
| Buck, M; Chojkier, M; Halasz, NA; Hunter, T; Zhang, L | 1 |
| Christy, C; Hadoke, PW; Kenyon, CJ; Kotelevtsev, YV; Mullins, JJ; Seckl, JR; Walker, BR; Williams, BC | 1 |
| Brochet, B; Deloire-Grassin, MS; Petry, KG; Touil, T; Vital, C | 1 |
| Rivier, C; Seo, DO | 1 |
| Fan, ZZ; He, RR; Wang, S | 1 |
| Choi, CR; Choi, JW; Jang, ES; Ju, C; Kim, HC; Kim, WK; Ko, KH; Shin, CY | 1 |
| Choi, JW; Jang, ES; Kim, HC; Kim, WK; Ko, KH; Ryu, JH; Shin, CY | 1 |
| Kang, TM; Lee, SW | 1 |
| Khramtsov, VV; Sergeeva, SV; Slepneva, IA | 1 |
| Barnes, WS; Demaree, S; Lawler, JM; Song, W; Wu, G | 1 |
| Cooke, CL; Davidge, ST | 1 |
| Dickens, EJ; Fukuta, H; Hashitani, H; Suzuki, H | 1 |
| Kato, Y; Maruyama, W; Naoi, M; Sato, Y; Shamoto-Nagai, M; Tanaka, M; Yamamoto, T; Yi, H | 1 |
| Correia, NC; Guarino, MP; Macedo, MP; Raposo, J | 1 |
| Buxton, IL; Malmquist, NA; Tichenor, S | 1 |
| McKoy, ML; Simon, OR | 1 |
| Daiber, A; Frein, D; Namgaladze, D; Ullrich, V | 1 |
| Almaas, R; Pleasure, D; Rootwelt, T; Saugstad, OD | 1 |
| Mak, IT; Weglicki, WB; Zhang, J | 1 |
| Masuda, M; Nishino, H; Ohshima, H | 1 |
| Kamisaki, Y; Maeda, S; Saeki, M; Wada, K | 1 |
| Del Carlo, M; Loeser, RF | 1 |
| Karpman, D; Persson, K; Poljakovic, M; Svanborg, C | 1 |
| Böddinghaus, B; Briner, VA; Dorsch, S; Franzen, R; Huwiler, A; Pautz, A; Pfeilschifter, J | 1 |
| Folkerts, G; Habernickel, J; Muijsers, RB; Nijkamp, FP; Postma, DS; van der Veeken, A | 1 |
| da Rocha, FA; de Brum-Fernandes, AJ | 1 |
| Adnot, S; Brun-Buisson, C; Delclaux, C; Harf, A; Jean, D; Maître, B; Meignan, M; Tankovic, J | 1 |
| Hisatsune, T; Kaieda, I; Kaji, T; Kaminogawa, S | 1 |
| Cooney, RV; Floyd, RA; Gabbita, SP; Grammas, P; Hensley, K; Markesbery, WR; Mou, S; Pye, QN; Reimann-Philipp, U; West, M; Williamson, KS | 1 |
| Bross, S; Gürkan, L; Jünemann, KP; Kadioğlu, A; Kayaarasi, Z; Manning, M; Sazova, O | 1 |
| Li, CQ; Trudel, LJ; Wogan, GN | 1 |
| Kim, JH; Kim, SB; Lee, SK; Park, JS; Park, SK; Yang, WS | 1 |
| Azarov, VI; Harmatina, OIu; Moĭbenko, OO | 1 |
| Hiraishi, H; Oinuma, T; Sasai, T; Shimada, T; Terano, A; Yoshiura, K | 1 |
| Chen, HJ; Li, DY; Mehta, JL | 1 |
| Motohashi, N; Saito, Y | 1 |
| Hayakawa, A; Hayashi, S; Kobayashi, T; Liu, DG; Nagasaka, T; Nakao, A; Negita, M; Yokoyama, I | 1 |
| Mazza, R; Pellegrino, D; Randall, DJ; Sprovieri, E; Tota, B | 1 |
| Antunes, E; Conran, N; De Nucci, G; Ferreira, HH; Kandratavicius, L; Lodo, ML; Martins, AR; Salaroli, AF | 1 |
| Murakami, Y; Okada, S; Yokotani, K | 1 |
| Buhler, DR; Deinzer, ML; Miranda, CL; Schimerlik, M; Stevens, JF; Wolthers, KR | 1 |
| Bourreau, JP; Deng, C; Shan, Q; Yin, X | 1 |
| Lucius, R; Rosenstiel, P; Sievers, J | 1 |
| Cairo, G; Campanella, A; Minotti, G; Recalcati, S; Ronchi, R | 1 |
| Lawler, JM; Song, W | 1 |
| Kerrigan, CL; Khiabani, KT | 1 |
| Choi, CR; Choi, JW; Jang, ES; Kim, HC; Kim, WK; Ko, KH; Ryu, JR; Shin, CY | 1 |
| Cornish, AS; Jijon, H; Madsen, KL; Yachimec, C | 1 |
| Andréjack, M; Colas, B; Masson, H; Remadi, JP; Slama, M | 1 |
| Li, S; Quock, RM | 1 |
| Biasetti, M; Dawson, R | 1 |
| Droogmans, G; Nilius, B; Suh, SH; Watanabe, H | 1 |
| Lee, S; Rivier, C; Seo, DO | 2 |
| Arkan, F; Aygoren, O; Guven, H; Kalkan, S; Kurt, S; Murat, N; Tuncok, Y | 1 |
| Belcourt, A; Benhamou, PY; Karsten, V; Kessler, L; Lemarchand, P; Moriscot, C; Pinget, M; Poindron, P; Sigrist, S | 1 |
| Esumi, H; Kimura, H; Kurashima, Y; Ogura, T; Weisz, A | 1 |
| Lisý, V; Stastný, F | 1 |
| Laude, K; Richard, V; Thuillez, C | 1 |
| Choi, JJ; Kim, HC; Kim, WK; Ko, KH; Kong, MY; Lee, SJ | 1 |
| Buchholzer, ML; Klein, J | 2 |
| Choi, JS; Chung, HY; Kim, AR; Kim, JE; Zou, Y | 1 |
| Haskew, RE; Kimelberg, HK; Mongin, AA | 1 |
| Freels, JL; Habib, M; Hoyt, JC; Lantz, RC; Nelson, DK; Numanami, H; Robbins, RA | 1 |
| Rosenberg, PA; Zhang, Y | 2 |
| Kim, CS; Kim, SB; Lee, SK; Park, JS; Park, SK; Yang, WS | 1 |
| Graier, WF; Groschner, K; Malli, R; Schmidt, K; Thyagarajan, B | 1 |
| Josephs, M; Katan, M; Rodrigues-Lima, F | 1 |
| Brimer, CM; Hooper, DC; Kean, RB; Koprowski, H; Mikheeva, T; Scott, GS; Spitsin, SV; Zborek, A | 1 |
| Assreuy, J; Costa, RS | 1 |
| Bao, F; Liu, D | 2 |
| Choi, SH; Kang, KW; Kim, SG | 1 |
| Hooper, DC; Kean, RB; Koprowski, H; Mikheeva, T; Scott, GS; Spitsin, SV | 1 |
| Di Giovanni, G; Ferraro, G; Galati, S; La Grutta, V; Sardo, P | 1 |
| Drapier, JC; Soum, E | 1 |
| Afonso, RA; Guarino, MP; Macedo, MP; Raimundo, N; Raposo, JF | 1 |
| Arlotto, M; Favier, A; Guiraud, P; Laude, H; Lehmann, S; Rachidi, W; Riondel, J; Vilette, D | 1 |
| Bao, F; DeWitt, DS; Liu, D; Prough, DS | 2 |
| Christen, S; Ferriero, DM; Francisco, C; Gregory, G; Manabat, C; Täuber, M; Vexler, ZS; Wong, A | 1 |
| Kikura-Hanajiri, R; Lunte, SM; Martin, RS | 1 |
| Brzozowski, T; Konturek, PCh; Konturek, SJ; Kwiecień, S | 1 |
| Adamek-Guzik, T; Korbut, R; Korbut, RA; Madej, J | 1 |
| Acierno, R; Pellegrino, D; Tota, B | 1 |
| Chu, CP; Ishizuka, Y; Jin, QH; Kannan, H; Kato, K; Kunitake, T; Qiu, DL | 1 |
| Bonikovski, V; Costa, PG; Futuro Neto, HA; Pires, JG; Saraiva, FP | 1 |
| Kil, IS; Kim, SY; Lee, JH; Park, JW; Yang, ES | 1 |
| Ckert, S; Frlich, Jr; Jonas, U; Machtens, S; Stief, CG; Tsikas, D | 1 |
| Barnes, PJ; Donnelly, LE; Fenwick, PS; Jones, GE; Nabeyrat, E | 1 |
| Burch, P; Heintz, NH; Janssen-Heininger, Y; Schellekens, H; Warner, L; Yuan, Z | 1 |
| Di Giovanni, G; Esposito, E; Ferraro, G; Galati, S; La Grutta, V; Sardo, P | 1 |
| Iida, H; Inoue, N; Ishida, H; Ishikawa, Y; Yuan, Z | 1 |
| Clements, MK; Hanson, AJ; Nelson-Overton, LK; Quinn, MT; Rohn, TT; Siemsen, DW; Swain, SD | 1 |
| Donham, DC; Frossard, M; Homoncik, M; Jilma, B; Keuzer, C; Sorenson, JR | 1 |
| Brandes, RP; Gambaryan, S; Holtwick, R; Kuhn, M; Sabrane, K; Voss, M | 1 |
| Denicola, A; Radi, R; Thomson, L | 1 |
| Akaike, A; Hashino, A; Kaneko, S; Katsuki, H; Kume, T; Osakada, F | 1 |
| Fukuda, S; Takakura, K; Takeuchi, K; Xiaohong, W; Yasuda, Y | 1 |
| Cedzyński, M; Klink, M; St Świerzko, A; Sulowska, Z; Tchórzewski, H | 1 |
| McConnell, P; Reasor, MJ; Van Dyke, K | 1 |
| Aoyagi, K | 1 |
| Beltrán, A; González, D; Herrera, B; Otero, K; Quintero, G; Rojas, A | 1 |
| Chakrabarti, S; Gan, XT; Karmazyn, M | 1 |
| Alvarez-Leite, JI; Cortes, SF; Lemos, VS; Rabelo, LA | 1 |
| Ferreira, SH; Parada, CA; Vivancos, GG | 1 |
| Arai, H; Fukunaga, K; Furumoto, H; Kuramitsu, Y; Mohri, S; Nagasaka, Y; Nakamura, K; Uchida, K | 1 |
| Cai, T; Tang, X; Wang, PG | 1 |
| Benhamou, PY; Favrot, MC; Moriscot, C; Richard, MJ | 1 |
| Buoncristiani, U; Canestrari, F; Davenport, A; Ferraro, B; Frei, B; Galli, F; Kingdon, E; Moore, KP; Rice-Evans, C | 1 |
| Di Giovanni, G; Ferraro, G; La Grutta, V; Sardo, P | 1 |
| Akaike, A; Honda, Y; Kashii, S; Yamauchi, T; Yasuyoshi, H; Zhang, S | 1 |
| Buxton, IL; Malmquist, NA; Tichenor, SD | 1 |
| Aoyagi, K; Cho, EJ; Rhyu, DY; Yokozawa, T | 1 |
| Carbonneau, MA; Descomps, B; Leger, CL; Shafiee, M; Urban, N | 1 |
| Bai, P; Bakondi, E; Csernoch, L; Gergely, P; Gönczi, M; Hunyadi, J; Kovács, L; Pacher, P; Szabó, C; Szabó, E; Virág, L | 1 |
| Arner, A; Ekblad, E; Harnek, J; Perez de Sá, V; Schou, H; Sjuve, R; Stenram, U; Zoucas, E | 1 |
| John, EO; Jung, TT; Kim, PD; Llaurado, RJ; Nam, BH; Park, SK | 1 |
| Ebadi, M; Sharma, SK | 1 |
| Frangos, JA; McKittrick, J; Muyco, J; Suzuki, R | 1 |
| Acosta, F; Díaz, R; Ellis, AE; Padilla, D; Real, F; Ruiz de Galarreta, CM | 1 |
| Akhter, S; Green, JR; Mutus, B; Root, P; Thatcher, GJ | 1 |
| Franke, RP; Grewe, R; Jung, F; Mrowietz, C; Seyfert, UT | 1 |
| Alexander, B; Benjamin, IS; Li, X | 1 |
| Chen, Z; Li, R; Wang, W; Xiao, J | 1 |
| Barth, C; Gebhard, MM; Martin, E; Walther, A | 1 |
| Chae, MR; Choi, JW; Insuk, SO; Lee, SW; Sim, JH; Yang, DK | 1 |
| Falke, KJ; Gerlach, H; Keh, D; Kürer, I; Thieme, A | 1 |
| Guimarães, FS; Molchanov, ML; Moreira, FA | 1 |
| Chen, L; Forman, HJ; Kirk, MC; Lazrak, A; Matalon, S; Thomas, MJ; Thome, U | 1 |
| Gugliucci, A | 1 |
| Alloatti, G; Bedendi, I; Gallo, MP; Levi, RC; Malan, D; Marcantoni, A | 1 |
| He, BP; Sopper, M; Strong, M | 1 |
| Aldini, G; Carini, M; Facino, RM; Piccoli, A; Rossoni, G | 1 |
| Chen, GQ; Chen, Z; Du, KM; Huang, Y; Li, D; Liu, W; Tong, JH; Xue, ZH; Yan, H; Zhao, Q; Zhu, YS | 1 |
| Buhler, DR; Frei, B; Miranda, CL; Stevens, JF | 1 |
| Mak, IT; Weglicki, WB | 1 |
| Fukuda, S; Takakura, K; Takeuchi, K; Xiaohong, W | 1 |
| Cho, EJ; Rhyu, DY; Yokozawa, T | 1 |
| Delogu, MR; Desole, MS; Esposito, G; Miele, E; Miele, M; Migheli, R; Mura, MP; Rocchitta, G; Serra, PA; Taras, MG | 1 |
| de Dam, MY; Elmedal, B; Mulvany, MJ; Simonsen, U | 1 |
| Jenkins, J; Lounsbury, KM; Penar, PL; Tranmer, B; Wellman, TL; Zahr, R | 1 |
| Klink, M; Sulowska, Z; Tchorzewski, H | 1 |
| Atmane, N; Dairou, J; Dupret, JM; Rodrigues-Lima, F | 1 |
| Carlo, MD; Loeser, RF | 1 |
| Jun, CH; Lee, TS; Sohn, UD | 1 |
| Sadan, G; Tasatargil, A | 1 |
| Cobbs, CS; Harkins, LE; Samanta, M; Van Meir, EG; Wesemann, DR; Whisenhunt, TR | 1 |
| Giuntini, J; Giusti, L; Lucacchini, A; Mazzoni, MR | 1 |
| Bieber, A; Chung, E; Day, E; Ohgami, Y; Quock, RM | 1 |
| Keegan, RD; Li, S; Quock, RM; Sorg, BA | 1 |
| Déciga-Campos, M; López-Muñoz, FJ | 1 |
| Hisatomi, T; Ishibashi, T; Ito, S; Kimoto, T; Rao, NA; Wu, GS | 1 |
| Hiramoto, K; Kikugawa, K; Ohkawa, T | 1 |
| Ishikawa, H; Kameyama, K; Kawachi, S; Kitajima, M; Kubota, T; Kumai, K; Otani, Y; Saikawa, Y; Sano, K; Shimazu, M; Tanabe, M; Wakabayashi, G; Yoshida, M | 1 |
| Bedoya, FJ; Cahuana, GM; Jiménez, J; Ramírez, R; Sobrino, F; Tejedo, JR | 1 |
| Antunes, E; De Nucci, G; Marcondes, S; Moreira, J; Thomazzi, SM | 1 |
| Deeb, RS; Gamss, C; Hajjar, DP; Lindenbaum, R; Mittar, D; Resnick, MJ; Upmacis, RK | 1 |
| Berndt, G; Grosser, N; Hoogstraate, J; Schröder, H | 1 |
| Ohshima, H; Saleem, M | 1 |
| Chen, L; Fuller, CM; Kleyman, TR; Matalon, S | 1 |
| Crow, JP; Nielsen, VG | 1 |
| Maleque, MA; Motley, ED; Richardson, SM | 1 |
| Cho, KW; Cui, X; Jin, JY; Kim, SH; Kim, SM; Kim, SZ; Lee, HS; Wen, JF | 1 |
| Rojas Wahl, RU | 1 |
| Ayuk, PT; Glazier, JD; Greenwood, SL; Khullar, S; McCord, N | 1 |
| Bau, DT; Chien, YH; Jan, KY | 1 |
| Andreatta, C; Hanson, AJ; Kumar, B; Nahreini, P; Prasad, JE; Prasad, KN; Yan, XD | 1 |
| Cao, Z; Li, Y | 2 |
| Chandross, KJ; Flint, N; Lee, L; Merrill, J; Takao, T; Ying, X | 1 |
| Crow, JP; Nielsen, VG; Parks, DA; Zhou, F | 1 |
| Atilano, SR; Brown, DJ; Chwa, M; Kenney, MC; Kim, DW; Lin, B | 1 |
| Kim, KH; Kim, SK; Kim, SM; Kwon, SR; Lee, EH; Nam, YK | 1 |
| Sadan, G; Tuncel, BI | 1 |
| Chou, YC; Chu, JJ; Chu, Y; Chueh, HY; Lin, PJ; Liu, HP; Wu, YC | 1 |
| Burch, PM; Heintz, NH; Loonen, A; Yuan, Z | 1 |
| Brading, AF; Deka, DK | 1 |
| Cimmino, G; Di Meglio, S; Jones, R; Quesada, P; Tramontano, F | 1 |
| Kimelberg, HK | 1 |
| Chacon, I; Kennedy, RH; Khurana, S; Raufman, JP; Wess, J; Xie, G; Yamada, M | 1 |
| Han, ES; Kim, KY; Lee, CS; Song, JH | 1 |
| Arai, H; Nakamura, K | 1 |
| Choi, JB; Igarashi, Y; Kashiwagi, A; Kawamori, R; Maegawa, H; Mineki, R; Murayama, K; Nomiyama, T; Ogihara, T; Taka, H; Tanaka, Y; Uchida, T; Uchino, H; Watada, H | 1 |
| Jue Denis, P; Laffy, PY; Le Blevec, G; Le Guen, O; Leblanc, G; Michel, C; Riou, JY; Sarfati, L | 1 |
| Arai, T; Maruyama, K; Ohuchi, T; Shibata, Y; Sugawara, F; Yoshida, K | 1 |
| Guimarães, FS; Moreira, FA | 1 |
| Crow, JP; Mogal, A; Nielsen, VG; Parks, DA; Zhou, F | 1 |
| Lin, PJ; Lin, YM; Wang, YC; Wu, YC; Yeh, CH | 1 |
| Juang, HH | 1 |
| Dal Rio, FP; Haslett, C; Megson, IL; Rossi, AG; Shaw, CA; Taylor, EL | 1 |
| Jantos, H; Monti, JM | 1 |
| Christoph, S; de Groot, H; Kirsch, M; Petrat, F; Swintek, AU | 1 |
| Jang, JH; Lim, SY; Lu, SC; Na, HK; Rahman, I; Surh, YJ | 1 |
| Chan, SH; Hsu, KS; Huang, CC | 1 |
| Angelini, G; Jeremy, JY; Muzaffar, S; Shukla, N | 1 |
| Flammer, J; Haefliger, IO; Wu, R; Yao, K | 1 |
| Correia, NC; Guarino, MP; Lautt, WW; Macedo, MP | 1 |
| Donohue, TM; Haorah, J; Krutik, VM; Osna, NA | 1 |
| Kim, SG; Kim, SO | 1 |
| Dikalov, S; Greilberger, J; Oettl, K; Reibnegger, G | 1 |
| Muyderman, H; Nilsson, M; Sims, NR | 1 |
| Mak, IT; Nedelec, LF; Weglicki, WB | 1 |
| Desole, MS; Esposito, G; Miele, E; Miele, M; Migheli, R; Mura, MP; Rocchitta, G; Serra, PA | 1 |
| Huang, XL; Pan, BX; Zhao, GL; Zhao, KS | 1 |
| Steinberg, H | 1 |
| Han, BH; Ju, C; Kim, HC; Kim, HS; Kim, WK; Oh, YJ | 1 |
| Gu, Y; Lewis, DF; Wang, Y; Zhang, Y; Zhao, S | 1 |
| Palmerini, CA; Pellegrino, D; Tota, B | 1 |
| Chen, HL; Gibson, GE; Huang, HM; Ou, HC; Zhang, H | 1 |
| Choi, WT; Han, ES; Lee, CS; Youn, YC | 1 |
| Camargo, C; López-Alarcón, C; Núñez-Vergara, LJ; Olea-Azar, C; Speisky, H; Squella, JA | 1 |
| Aizenman, E; Jimenez, DA; Levitan, ES; Li, J; Rosenberg, PA; Wang, H; Zhang, Y | 1 |
| Acquaviva, R; Avola, R; Barcellona, ML; Campisi, A; Li Volti, G; Mangiameli, S; Murabito, P; Musumeci, I; Raciti, G; Vanella, A | 1 |
| Fu, J; Wang, HB; Wang, WZ | 1 |
| Eapen, A; Sharma, A; Subbarao, SK | 1 |
| Gutiérrez-Martin, Y; Gutiérrez-Merino, C; Henao, F; Martin-Romero, FJ | 2 |
| Kim, KW; Lee, KP; Nakamura, E; So, I; Suzuki, H | 1 |
| Eldred, WD; Yu, D | 1 |
| Kina, VA; Prado, WA; Villarreal, CF | 1 |
| Bang, H; Han, ES; Lee, CS; Park, ES | 1 |
| Andersen, CU; Mulvany, MJ; Simonsen, U | 1 |
| Adapala, NS; Chan, MM; Fong, D | 1 |
| Cho, EJ; Ikeshiro, Y; Kashiwada, Y; Satoh, A; Yokozawa, T | 1 |
| Richard, V; Savoye, G; Tamion, F; Thuillez, C; Varin, R | 1 |
| Cai, TB; Landerholm, M; Lu, D; Tang, X; Wang, PG; Zhang, Y | 1 |
| Bachschmid, M; Schildknecht, S; Ullrich, V | 1 |
| Ginsburg, I; Kohen, R; Oron, M; Sadovnic, M | 2 |
| Brugnara, C; De Franceschi, L; Di Stasi, AM; Mallozzi, C | 1 |
| Abiru, S; Eguchi, K; Ishibashi, H; Komori, A; Maeda, Y; Migita, K; Nakamura, M; Takii, Y; Yatsuhashi, H; Yokoyama, T | 1 |
| Fernández, JL; Gosálvez, J; Mosquera, A; Sabatier, L | 1 |
| Kennedy, RH; Khurana, S; Raufman, JP; Wess, J; Yamada, M | 1 |
| Bucurescu, S; Harper, ME; Lach, B; Lee, F; Li, Y; McRae, K; Rippstein, P; Sandhu, JK; Sikorska, M; Sodja, C; Wei, YH | 1 |
| Pellegrino, D; Randall, DJ; Tota, B | 1 |
| Elmedal Laursen, B; Mulvany, MJ; Simonsen, U | 1 |
| Banasik, M; Klink, M; Majewska, E; Sulowska, Z; Tchórzewski, H | 1 |
| Genetta, T; Moore, JE; Peng, H; Rogido, MR; Sola, A; Wen, TC | 1 |
| Cao, TT; Hess, JF; Kandpal, G; Ma, L; Seabrook, GR; Warren, L | 1 |
| Dairou, J; Dupret, JM; Rodrigues-Lima, F | 1 |
| Choi, JW; Choi, MS; Ko, KH; Park, GH; Ryu, MK; Yoo, BK | 1 |
| Bottari, SP; Garrido, MR; Levy, P; Pinzar, E; Wang, T; Xu, W | 1 |
| Booze, RM; Dodson, SL; Nath, A; Wallace, DR | 1 |
| Choi, JW; Choi, MS; Jeon, MJ; Ko, KH; Park, GH; Ryu, MK; Yoo, oK | 1 |
| Diez-Orejas, R; Gil, C; Guillén, MV; Martínez-Solano, L; Molero, G; Nombela, C; Pla, J; Sánchez-Pérez, M | 1 |
| Acquaviva, R; Avola, R; Barcellona, ML; Campisi, A; Li Volti, G; Raciti, G; Vanella, L | 1 |
| Desole, MS; Esposito, G; Marchetti, B; Miele, E; Migheli, R; Mura, MP; Rocchitta, G; Serra, PA | 1 |
| Austin, RC; Dickhout, JG; Hossain, GS; Lhoták, S; Pozza, LM; Zhou, J | 1 |
| Booze, RM; Dodson, S; Nath, A; Wallace, DR | 1 |
| Kim, BJ; Moon, KH; Song, BJ | 1 |
| Clemens, DL; Donohue, TM; Osna, NA | 1 |
| Abrescia, P; Carlucci, A; Cigliano, L; Spagnuolo, MS | 1 |
| Bramey, T; De Groot, H; Kirsch, M; Petrat, F | 1 |
| Aviram, M; Soliman, K; Szuchman, A; Tamir, S; Vaya, J | 1 |
| Alexander, JS; Gu, Y; Lewis, DF; Wang, Y; Zhang, Y; Zhao, S | 1 |
| Bjursten, LM; Contreras, R; Frangos, JA; Gaskill, DF; Sahlin, H | 1 |
| Mori, H; Pearson, JT; Schwenke, DO; Shirai, M; Tsuchimochi, H | 1 |
| Mori, H; Pearson, JT; Schwenke, DO; Shirai, M | 1 |
| Heintz, NH; Ranjan, P | 1 |
| Chmurzyński, L; Dabrowska, A; Figarski, A; Jacewicz, D; Lapińska, A; Woźniak, M | 1 |
| Aptecar, E; Dubois-Rande, JL; Dupouy, P; Garot, P; Hittinger, L; Lecorvoisier, P; Loisance, D; Montagne, O; Sediame, S; Teiger, E; Vermes, E | 1 |
| Hornback, ML; Roop, RM | 1 |
| Barbar, EJ; Deeb, RS; Gross, SS; Hajjar, DP; Hao, G; Lainé, M; Qiu, JH; Resnick, B; Upmacis, RK | 1 |
| Hader, W; Yang, C; Zhang, X | 1 |
| Aureliano, M; Gutiérrez-Merino, C; Ramos, S; Tiago, T | 1 |
| Cherenkevich, SN; Kulahava, TA; Kvacheva, ZB; Semenkova, GN; Timoshenko, AV | 1 |
| Guarino, MP; Macedo, MP | 1 |
| Cheng, ML; Chiu, DT; Ho, HY; Wei, TT | 1 |
| Guimarães, FS; Joca, SR | 1 |
| Aureliano, M; Gutiérrez-Merino, C; Martín-Romero, FJ; Simão, S; Tiago, T | 1 |
| Doke, N; Kawakita, K; Saito, S; Yamamoto-Katou, A; Yoshioka, H | 1 |
| Lev, N; Melamed, E; Offen, D | 1 |
| Jeong, TS; Lee, WS; Oh, HW; Park, DS; Park, HY; Song, KB; Xu, MZ; Yoon, MA | 1 |
| Moon, HK; Park, JW; Yang, ES | 1 |
| Cha, YN; Li, MH; Surh, YJ | 2 |
| Kangawa, K; Pearson, JT; Schwenke, DO; Shirai, M | 1 |
| El Bohi, K; Fujita, S; Ishizuka, M; Kazusaka, A; Muzandu, K; Sakamoto, KQ; Shaban, Z | 1 |
| Bonatti, J; Fersterer, J; Hammerer-Lercher, A; Hoefer, D; Holzmann, S; Mair, J; Puschendorf, B; Ruttmann, E | 1 |
| Bar-Shai, M; Reznick, AZ | 1 |
| Alegre, E; Díaz, A; González, A; López, AS; Mugueta, C | 1 |
| Pollard, SE; Spencer, JP; Whiteman, M | 1 |
| Bieber, AJ; Burke, B; Chung, E; Doss, JC; Ohgami, Y; Quock, RM | 1 |
| Braga, FC; Cortes, SF; Ferreira, HC; Lemos, VS; Serra, CP | 1 |
| Dirnagl, U; Dreier, JP; Lindauer, U; Scheckenbach, KE | 1 |
| Christopher, TA; Coletti, C; Gao, E; Hu, A; Koch, W; Lopez, BL; Ma, XL; Tao, L; Wang, Y | 1 |
| Kaundal, RK; Shah, KK; Sharma, SS | 1 |
| Akerström, S; Falk, KI; Hardestam, J; Klingström, J; Lundkvist, A; Mirazimi, A; Rottenberg, M; Simon, M; Stoltz, M | 1 |
| Christopher, T; Gao, E; Jiao, X; Koch, W; Lau, WB; Lopez, B; Ma, XL; RamachandraRao, SP; Sharma, K; Southan, G; Tao, L; Williams, W; Yuan, Y | 1 |
| Dawson, TM; Dawson, VL; Holmes, S; Jiang, H; Liang, Y; Nakamura, M; Ross, CA; Smith, WW; Tanaka, Y; Wu, YC | 1 |
| Idell, S; Liu, MC; Yasuda, S | 1 |
| Ebadi, M; Sharma, S | 1 |
| Carletti, F; D'Agostino, S; Ferraro, G; Rizzo, V; Sardo, P | 1 |
| Bar-Shai, M; Hasnis, E; Reznick, AZ; Wiener-Megnazi, Z | 1 |
| Arundine, M; Jones, M; Lau, A; Sun, HS; Tymianski, M | 1 |
| Hegde, KR; Varma, SD | 1 |
| Bawankule, DU; Mishra, SK; Raviprakash, V; Sardar, KK; Sarkar, SN | 1 |
| Almanza, A; Navarrete, F; Soto, E; Vega, R | 1 |
| Klassen, SS; Rabkin, SW | 3 |
| Bringuier, AF; Feldmann, G; Guillot, R; Legrand, A; Nello, E; Vadrot, N | 1 |
| Han, ES; Kim, YJ; Lee, CS | 1 |
| Carbonneau, MA; Fouret, G; Leger, CL; Torres-Rasgado, E | 1 |
| Luchowski, P; Urbanska, EM | 1 |
| Angelos, MG; Aune, SE; Falk, JA; Kuppusamy, P; Kutala, VK | 1 |
| Hall, ED; Singh, IN; Sullivan, PG | 1 |
| Antunes-Rodrigues, J; Elias, LL; Giusti-Paiva, A; Gomes, DA; Margatho, LO; Reis, WL; Ventura, RR | 1 |
| Gams, E; Garcia, SC; Langenbach, MR; Pomblum, V; Schipke, JD | 1 |
| Girard, T; Ince, C; Schwarte, LA; Siegemund, M; Sinaasappel, M; Studer, W; Van Bommel, J; Vollebregt, K | 1 |
| Faggio, C; Pidalà, P; Trischitta, F | 1 |
| Hashitani, H; Suzuki, H | 1 |
| Banasik, M; Bednarska, K; Jastrzembska, K; Klink, M; Sulowska, Z | 2 |
| Je, HD; Lee, YP; Shin, CY; Sohn, UD; Song, HJ | 1 |
| Amit, T; Bar-Am, O; Blumenfeld, Z; Kupershmidt, L; Youdim, MB | 1 |
| Cha, YN; Jang, JH; Li, MH; Na, HK; Surh, YJ | 1 |
| Dairou, J; Dupret, JM; Haddad, I; Mary, J; Noiran, J; Petit, E; Pluvinage, B; Rodrigues-Lima, F; Vinh, J | 1 |
| Rehder, V; Welshhans, K | 1 |
| Bergoc, R; Cricco, G; Gutiérrez, A; Martín, G; Medina, V; Mohamad, N; Núñez, M; Rivera, E | 1 |
| Angelini, GD; Jeremy, JY; Johnson, JL; Shukla, N; Wan, S; Yim, AP | 1 |
| Jin, S; Kawanokuchi, J; Mizuno, T; Sonobe, Y; Suzumura, A; Takeuchi, H; Wang, J | 1 |
| Hashitani, H; Hayase, M; Kohri, K; Sasaki, S; Suzuki, H; Yanai, Y | 1 |
| Delaney, JC; Delaney, S; Essigmann, JM | 1 |
| Davies, CM; Fermor, B; Guilak, F; Weinberg, JB | 1 |
| Aoki, T; Arai, T; Kamisuki, S; Kimoto, K; Kobayashi, S; Kuramochi, K; Kuroiwa, K; Nakazaki, A; Shibata, Y; Sugawara, F; Watanabe, N | 1 |
| Black, SA; Ferguson, SS; Pholpramool, C; Pinthong, M; Ribeiro, FM; Rylett, RJ | 1 |
| Lei, T; Liu, ZW; Yang, Z; Zhang, T | 1 |
| Kohr, MJ; Velayutham, M; Wang, H; Wheeler, DG; Ziolo, MT; Zweier, JL | 2 |
| An, Z; Cherrington, AD; Dardevet, DP; DiCostanzo, CA; Edgerton, DS; Moore, MC; Neal, DW | 1 |
| Greenberg, DA; Jin, K; Khan, AA; Mao, XO; Xie, L | 1 |
| Burdo, J; Maher, P; Schubert, D | 1 |
| Kiagiadaki, F; Mastrodimou, N; Thermos, K | 1 |
| Cherrington, AD; Dicostanzo, CA; Farmer, B; Moore, MC; Neal, DW; Rodewald, TD; Smith, MS; Williams, PE | 1 |
| Beconi, MT; Rodriguez, PC | 1 |
| Cui, J; Jang, MH; Piao, X; Piao, XL | 1 |
| Cho, EJ; Jang, MH; Piao, XL | 1 |
| Dallas, ML; Peers, C; Scragg, JL | 1 |
| D'angelo, V; Galati, S; Martorana, A; Procopio, T; Sancesario, G; Scarnati, E; Stanzione, P; Stefani, A | 1 |
| Axelrod, S; Brinkmann, V; Enders, J; Haas, A; Kaufmann, SH; Oschkinat, H; Schaible, UE; Schlegel, B | 1 |
| Allodi, S; Baisch, AL; Cousin, JC; Cruz, BP; Geihs, MA; Maciel, FE; Nery, LE; Trindade, GS; Vargas, MA | 1 |
| Ariz, I; Arrese-Igor, C; Auzmendi, I; González, EM; Larrainzar, E; Moran, JF; Urarte, E | 1 |
| Davies, MJ; Kennett, EC | 1 |
| Acierno, R; Amelio, D; Gattuso, A; Guerrieri, A; Mannarino, C; Tota, B | 1 |
| Cepinskas, G; Inculet, R; Mehta, S; Shelton, JL; Wang, L | 1 |
| Beart, PM; Nagley, P; O'Shea, RD; Wallis, N; Zagami, CJ | 1 |
| Ashki, N; Bao, F; Hayes, KC | 1 |
| Kang, KS; Park, JC; Rhyu, DY; Sekiya, M; Tanaka, T; Yokozawa, T | 1 |
| Asatryan, L; Gallaher, TK; Hamilton, RT; Hsiai, TK; Isas, JM; Nilsen, JT; Sawamura, T | 1 |
| Alegre, E; Carosella, ED; Díaz-Lagares, A; González, A; LeMaoult, J | 1 |
| Bolás-Fernández, F; Dea-Ayuela, MA; Ordoñez-Gutierrez, L | 1 |
| Akamatsu, K; Furukawa, K; Hayata, A; Hirano, T; Ichikawa, T; Ichinose, M; Kanda, M; Koarai, A; Matsunaga, K; Minakata, Y; Nakanishi, M; Sugiura, H; Yanagisawa, S | 1 |
| Fujita, K; Niki, E; Nishio, K; Ogawa, Y; Omata, Y; Saito, Y; Yoshida, Y | 1 |
| Brzozowski, T; Konturek, PC; Konturek, SJ; Pawlik, MW; Pawlik, WW; S Kwiecien, S; Sliwowski, Z | 1 |
| Aoki, K; Kato, S; Saso, N; Sato, H; Sugiyama, Y | 1 |
| Gao, Z; Lu, N; Zhang, Y | 1 |
| Aldinucci, C; Blanco Garcia, J; Buonocore, G; Maiorca, SM; Palmi, M; Pessina, GP; Valoti, M | 1 |
| Amelio, D; Cerra, MC; Garofalo, F; Pellegrino, D; Sidell, BD; Tota, B | 1 |
| Hotter, G; Jung, M; Sola, A; Viñas, JL | 1 |
| Arai, T; Fujieda, S; Kobayashi, S; Kuramochi, K; Nakajima, M; Nakazaki, A; Ohnishi, K; Saitoh, Y; Sugawara, F; Takeuchi, T; Watanabe, N | 1 |
| Jia, Z; Li, Y; Misra, BR; Misra, HP; Vitto, MJ; Zhu, H | 1 |
| Braga, PC; Culici, M; Dal Sasso, M; Fonti, E | 1 |
| Belaaouaj, A; Crouch, EC; Gao, Z; Kirk, M; Matalon, S; McDonald, B; Shrestha, K; Smith, K; Waldheuser, S | 1 |
| Gabrielson, KL; Jia, Z; Li, Y; Misra, HP; Santo, A; Zhou, K; Zhu, H | 1 |
| Arai, T; Konishi, K; Watanabe, N | 1 |
| Cubero, FJ; Nieto, N; Urtasun, R; Vera, M | 1 |
| Booij-James, IS; Edelman, M; Mattoo, AK | 1 |
| Carletti, F; D'Agostino, S; Ferraro, G; Lonobile, G; Rizzo, V; Sardo, P | 1 |
| McNamara, JC; Ribeiro, MR | 1 |
| Cho, EJ; Cui, J; Jang, MH; Piao, XL | 1 |
| Beverley, SM; Garraway, LA; Nare, B; Vickers, TJ | 1 |
| Boos, N; Hottiger, M; Poveda, L; Wuertz, K | 1 |
| Araki, Y; Hara, H; Imai, S; Inokuchi, Y; Matsunaga, N; Shimazawa, M; Yokota, S | 1 |
| Aguiar, DC; Braga, AA; Guimarães, FS | 1 |
| Bachschmid, MM; Daiber, A; Kamuf, J; Müller, J; Schildknecht, S; Ullrich, V | 1 |
| Hall, ED; Singh, IN; Xiong, Y | 1 |
| Amit, T; Carri, MT; Kupershmidt, L; Mandel, S; Weinreb, O; Youdim, MB | 1 |
| Baamonde, A; González-Rodríguez, S; Hidalgo, A; Menéndez, L | 1 |
| Durand, G; Han, Y; Ortial, S; Prosak, RA; Pucci, B; Rockenbauer, A; Villamena, FA | 1 |
| Huang, K; Zhou, J | 1 |
| Davidge, ST; Sankaralingam, S; Xu, H | 1 |
| Barbosa-Sicard, E; Brandes, RP; Braun, T; Fleming, I; Frömel, T; Hammock, BD; Keserü, B; Krüger, M; Morisseau, C | 1 |
| Chen, W; Jia, Z; Li, Y; Misra, HP; Zhou, K; Zhu, H | 1 |
| Chen, W; Jia, Z; Li, J; Li, Y; Misra, HP; Zhou, K; Zhu, H | 1 |
| Kim, JM; Kim, SY; Koo, JY; Koo, YK; Oh, D; Park, S; Yun-Choi, HS | 1 |
| Folkerts, G; Givi, ME; Janse, WT; Mortaz, E; Nijkamp, FP; Sarir, H | 1 |
| Antunes, E; Cardoso, MH; De Nucci, G; Lilla, S; Marcondes, S; Morganti, RP; Murad, F | 1 |
| Gao, X; Kadowitz, PJ; Murthy, SN; Raghavamenon, AC; Sathishkumar, K; Uppu, RM | 1 |
| Almeida, A; Bolaños, JP; Chiricozzi, E; Fernandez-Fernandez, S; Goracci, G; Nardicchi, V | 1 |
| Davis, JP; Kohr, MJ; Roof, SR; Traynham, CJ; Ziolo, MT | 1 |
| Amit, T; Bar-Am, O; Gross, Z; Kupershmidt, L; Mahammed, A; Mandel, S; Okun, Z; Saltsman, I; Youdim, MB | 1 |
| Lodhia, P; Luong, MW; Rabkin, SW | 1 |
| Kim, HS; Kim, M; Kim, MS; Koh, EH; Lee, KU; Lee, WJ; Oh, KS; Park, HS; Park, IS; Park, JY; Ranjan, KC; Youn, JH | 1 |
| Chung, HY; Kim, JM; Kim, MK; Lee, EK; Park, G; Yokozawa, T; Yu, BP | 1 |
| Chen, YJ; Hu, TM | 1 |
| Kim, H; Lim, JW; Mukaida, N; Seo, JY; Yu, JH | 1 |
| Miguel, TL; Pobbe, RL; Spiacci Junior, A; Zangrossi Junior, H | 1 |
| Jia, Z; Li, Y; Misra, HP; Zhu, H | 1 |
| Bi, L; Chen, H; Li, Y; Liu, X; Mao, Z; Qu, L; Xiong, J | 1 |
| Burns, ST; Doerge, DR; Hinson, JA; Holthoff, JH; Mayeux, PR; Woodling, KA | 1 |
| Matejovic, M; Radermacher, P; Stahl, W | 1 |
| Altun, A; Bagcivan, I; Durmus, N; Sarac, B; Sencan, M; Turan, M | 1 |
| Förstermann, U; Li, H | 1 |
| Chen, ML; Fan, Q; Ge, YG; Irwin, MG; Liu, SH; Liu, Y; Wang, LF; Wang, W; Xia, Z; Yang, XC; Zhang, LK | 1 |
| Guo, L; Liu, J; Xiao, H; Yin, F; Zheng, X | 1 |
| Domingo de Miguel, E; Iraburu, MJ; López-Zabalza, MJ; Mòdol, T; Natal, C; Pérez de Obanos, MP | 1 |
| Ho, SC; Hu, TM | 1 |
| Hu, SA; Si, ZP; Wang, QS | 1 |
| Jiang, X; Jung, SH; Kang, H; Kim, B; Kim, J; Lee, CK; Lee, HM; Lee, P; Lin, HY; Toyokuni, S; Won, KJ | 1 |
| Chen, CC; Hsu, YJ; Lee, TM | 1 |
| Delledonne, M; Gaupels, F; Spiazzi-Vandelle, E; Yang, D | 1 |
| Aggarwal, S; Black, SM; Datar, S; Fineman, JR; Fratz, S; Gross, CM; Kalkan, G; Kumar, S; Oishi, P; Schreiber, C | 1 |
| Aureliano, M; Gutierrez-Merino, C; Marques-da-Silva, D; Samhan-Arias, AK; Tiago, T | 1 |
| Ahn, MY; Chung, HY; De, U; Jung, JH; Kang, JA; Kim, HS; Kim, JM; Lee, J; Moon, HR; Patra, N | 1 |
| Gualda, LB; Guimarães, FS; Martins, GG; Müller, B; Oliveira, RM | 1 |
| Chimenti, D; Gambacciani, C; Scarpato, R; Svezia, B; Turchi, G | 1 |
| Enerson, BE; Lawton, MP; Peters, D; Sheth, CM; Weaver, JL | 1 |
| Aldinucci, C; Coppo, L; Di Giuseppe, D; Di Simplicio, P; Di Stefano, A; Frosali, S; Margaritis, A; Pessina, G; Priora, R; Summa, D | 1 |
| Fujimoto, S; Higashi, Y; Nagasawa, K; Nishida, K; Nishiura, T; Okuda, H; Tanaka, A | 1 |
| Gao, Z; Lu, N; Zhang, Y; Zhao, Y | 1 |
| Beaugé, L; DiPolo, R | 1 |
| Arner, A; de Sá, VP; Ekblad, E; Harnek, J; Stenram, U; Zoucas, E | 1 |
| Ahn, JH; Choe, MA; Han, JA; Kim, JI; Kim, KH | 1 |
| Andersson, B; Andersson, H; Golovliov, I; Lindgren, H; Sjöstedt, A; Tancred, L; Telepnev, MV | 1 |
| Lai, R; Li, S; Lin, W; Tchantchou, F; Wen, J; Zhang, Y | 1 |
| Dhammu, TS; Gilg, AG; Im, YB; Khan, M; Sakakima, H; Shunmugavel, A; Singh, AK; Singh, I | 1 |
| Alkilany, AM; Caldwell, RB; Caldwell, RW; Chandra, S; Romero, MJ; Shatanawi, A | 1 |
| Chen, W; Han, Q; Li, A; Li, J; Li, Y; Ye, L | 1 |
| Agbani, E; Coats, P; Wadsworth, RM | 1 |
| Altiok, S; Celis, E; Cheng, P; Gabrilovich, D; Lu, T; Pisarev, V; Ramakrishnan, R; Sherman, S; Sporn, MB; Youn, JI | 1 |
| Arnould, T; Boudjeltia, KZ; Caesens-Koenig, L; Calay, D; Mattart, L; Michiels, C; Raes, M; Roebroeck, L; Roebroek, L; Simon, D; Tevel, V; Van Steenbrugge, M | 1 |
| Askwith, T; Eggo, MC; Stevens, MJ; Zeng, W | 1 |
| Aoyama, K; Kikuchi-Utsumi, K; Kinoshita, C; Kiyonari, H; Matsumura, N; Nakaki, T; Shioi, G; Tanaka, K; Wang, F; Watabe, M | 1 |
| Barcikowska, M; Buizza, L; Buoso, E; Butterfield, DA; Cenini, G; Ferrari-Toninelli, G; Govoni, S; Lanni, C; Memo, M; Prandelli, C; Racchi, M; Styczynska, M; Szybinska, A; Uberti, D | 1 |
| Markowicz Bastos, DH; Matsumoto, RLT; Mendonça, S; Moura de Oliveira, D; Souza, MF | 1 |
| Lu, L; Shimizu, T; Tanaka, K; Yokotani, K | 1 |
| Chung, HT; Kim, KM; Park, YC; Song, JD | 1 |
| Badejo, AM; Bhartiya, M; Bueno, FR; Casey, DB; Kadowitz, PJ; Murthy, SN; Nossaman, BD; Pankey, EA; Uppu, RM | 1 |
| Ayton, S; Barnham, KJ; Bush, AI; Cappai, R; Cheng, L; Cherny, RA; Chiu, FC; Crouch, PJ; Culvenor, JG; Donnelly, PS; Finkelstein, DI; George, J; Hill, AF; Hung, LW; Leong, SL; Lim, S; Liu, X; Masters, CL; O'Keefe, G; Pham, CL; Powell, AK; Roberts, BR; Shackleford, DM; Sherratt, NA; Villemagne, VL; White, AR; Wilkins, S | 1 |
| Carail, M; Caris-Veyrat, C; Graham, DL; Lowe, GM | 1 |
| Black, SA; Cuddy, LK; Ferguson, SS; Gordon, AC; Jaworski, E; Rylett, RJ | 1 |
| Camejo, D; Florez-Sarasa, I; Jiménez, A; Martí, MC; Ortiz, A; Pallol, B; Ribas-Carbó, M; Sevilla, F | 1 |
| Kim, H; Kim, YA; Kong, CS; Lee, C; Lee, HS; Lee, JI; Park, HY; Seo, Y | 1 |
| Chiu, SJ; Ho, SC; Hu, TM | 1 |
| Fernandes, AB; Guarino, MP; Macedo, MP | 1 |
| Gekle, M; Grossmann, C; Meinel, S; Mildenberger, S; Rabe, S; Ruhs, S; Schlör, K; Strätz, N | 1 |
| Akashi, S; Arai, T; Fujieda, S; Kobayashi, S; Konishi, K; Kuramochi, K; Nakagawa, T; Ogura, Y; Okada, T; Shibata, Y; Shirai, K; Sugawara, F; Takahashi, M; Takeuchi, T; Watanabe, N | 1 |
| Akashi, S; Arai, T; Konishi, K; Murata, H; Okada, T; Shirai, K; Sugawara, F; Watanabe, N | 1 |
| Adak, S; Bose, M; Mukherjee, S; Roy, J; Saha, R; Sen Santara, S | 1 |
| Bédiar-Boulaneb, F; Belguendouz, H; Hartani, D; Lahlou-Boukoffa, OS; Lahmar-Belguendouz, K; Touil-Boukoffa, C | 1 |
| Hemanth Kumar, K; Khanum, F; Pal, A; Tamatam, A | 1 |
| Barroso, JB; Begara-Morales, JC; Carreras, A; Chaki, M; Corpas, FJ; López-Jaramillo, J; Sánchez-Calvo, B; Valderrama, R | 1 |
| Bonilla, IM; Cardounel, AJ; Carnes, CA; Györke, S; Nishijima, Y; Sridhar, A | 1 |
| Song, JL; Wang, Q; Zhang, T; Zhao, X | 1 |
| Jiajia, Y; Yongling, X; Zhaowei, L; Zhuo, Y | 1 |
| Cardounel, AJ; Das, A; De Pascali, F; Druhan, LJ; Gopalakrishnan, B; Racoma, I; Rockenbauer, A; Varadharaj, S; Villamena, FA; Wang, TY; Zweier, JL | 1 |
| Alameda, F; Alcolea, D; Boada, M; Bosch-Morató, M; Elosúa, R; Eraso-Pichot, A; Fernández-Busquets, X; Fortea, J; Guivernau, B; Ill-Raga, G; Lleó, A; Muñoz, FJ; Nuñez, L; Paez, A; Palomer, E; Ramos-Fernández, E; Román-Dégano, I; Tajes, M; Valverde, MA | 1 |
| Al-Hashimi, F; Al-Shboul, OA; Al-Shehabat, M; Mohammad, M; Mustafa, A; Yousef, A | 1 |
| Abaji, R; Coderre, TJ; Laferrière, A; Ragavendran, JV; Tsai, CY | 1 |
| Altun, A; Bagcivan, I; Durmus, N; Gursoy, S; Ozdemir, E | 1 |
| Bae, YC; Jung, JS; Kim, JY; Kim, YS; Lee, AL; Park, HJ; Park, YK; Shin, KK | 1 |
| Kim, K; Kim, KM; Lee, MS; Park, SE; Park, YC | 1 |
| Calcerrada, P; Cassina, A; de Bem, AF; Fiuza, B; Peluffo, G; Piacenza, L; Radi, R; Rocha, JB; Straliotto, MR; Subelzú, N | 1 |
| Boguen, R; Sánchez, R; Treulen, F; Uribe, P; Villegas, JV | 2 |
| An, JM; Hong, SY; Kang, JW; Moon, SA; Seo, JT | 1 |
| Akbarali, HI; Gade, A; Hashimoto, A; Kang, M | 1 |
| Arnhold, J; Flemmig, J; Koyani, CN; Malle, E | 1 |
| Gandhi, HP; Giridhar, R; Kanhed, AM; Mande, HM; Tamboli, RS; Yadav, MR | 1 |
| Bertoldo, JB; Terenzi, H | 1 |
| Álvarez, J; Cabrillana, ME; Fornés, MW; Sánchez, R; Uribe, P; Villegas, JV | 1 |
| Chung, E; Ohgami, Y; Quock, RM | 1 |
| Arias, ME; Cheuquemán, C; Felmer, R; Loren, P; Risopatrón, J; Sánchez, E; Sánchez, R | 1 |
| Krzemiński, TF; Mitręga, KA; Porc, M; Żorniak, M | 1 |
| Fedorova, M; Griesser, E; Grune, T; Raulien, N; Reeg, S; Vemula, V; Wagner, U | 1 |
| Abd El-Hay, SS; Colyer, CL | 1 |
| Gao, W; Gao, Z; Li, H; Zhao, J | 1 |
| Chakraborty, S; Datta, S; Ghosh, S; Panja, C | 1 |
| Miranowicz-Dzierżawska, K | 1 |
| Chen, J; Fang, Q; He, Y; Liu, H; Ma, T; Otero, M; Wang, H; Wang, M; Wang, W; Zhang, D; Zhang, M; Zhang, Y | 1 |
| Coimbra, NC; Falconi-Sobrinho, LL | 1 |
| Chen, J; He, Y; Jiang, Z; Otero, M; Wang, M; Zhang, D; Zhang, M; Zhang, Y | 1 |
| Chew, CY; Chung, TH; Lam, CH; Tan, KT; Wu, YP | 1 |
| Cao, SS; Cheng, Y; Han, J; Liang, H; Sun, L; Xiao, C; Xu, YW | 1 |
| Anderson, P; Aulas, A; Fay, MM; Ivanov, P; Lyons, SM | 1 |
| Lanner, JT; Persson, M; Rassier, DE; Steinz, MM; Westerblad, H | 1 |
| Kim, JE; Park, H | 1 |
| Escalante, B; Flores-Tamez, V; Rios, A | 1 |
| Alvarsson, M; Mahdi, A; Pernow, J; Tengbom, J; Wernly, B; Zhou, Z | 1 |
| Albuck, AL; Evans, WR; Katakam, PVG; Kolli, L; Mostany, R; Sakamuri, SSVP; Sperling, JA; Sure, VN | 1 |
| Coimbra, NC; Dos Anjos-Garcia, T; Falconi-Sobrinho, LL | 1 |
| Acharya, S; Dias, HV; Krishnamoorthy, RR; Rogers, P; Stankowska, DL; Yorio, T | 1 |
16 review(s) available for linsidomine and molsidomine
| Article | Year |
|---|---|
[Inhibition of platelet activation by endothelium-derived relaxing factor EDRF/NO and NO releasing dilator substances].
Topics: Animals; Arteriosclerosis; Humans; Molsidomine; Nitric Oxide; Platelet Aggregation; Thrombosis; Vasodilator Agents | 1991 |
[Endothelial factors and thrombocyte function].
Topics: Animals; Arteriosclerosis; Blood Platelets; Endothelium, Vascular; Epoprostenol; Humans; Molsidomine; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Vasodilator Agents | 1991 |
Response of coronary arteries to nitrates, the EDRF-donor SIN-1, and calcium antagonists.
Topics: Calcium Channel Blockers; Coronary Vasospasm; Coronary Vessels; Humans; Molsidomine; Nitrates; Nitroglycerin; Vasodilation | 1991 |
[Inhibition of platelet aggregation by endothelium-derived relaxing factor-like agents].
Topics: Animals; Coronary Circulation; Humans; Isosorbide Dinitrate; Molsidomine; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Vasodilator Agents | 1990 |
[SIN-1 in intracoronary administration].
Topics: Blood Circulation; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Circulation; Coronary Vessels; Drug Tolerance; Heart Rate; Humans; Injections, Intra-Arterial; Molsidomine; Nitroglycerin; Vasodilation | 1988 |
[Role of molsidomine on platelet activation in coronary ischemia].
Topics: Angina Pectoris; Angina, Unstable; Humans; Molsidomine; Myocardial Infarction; Platelet Aggregation Inhibitors | 1988 |
Effects of cytokines and nitric oxide donors on insulin secretion, cyclic GMP and DNA damage: relation to nitric oxide production.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cell Line; Cells, Cultured; Cyclic GMP; Cytokines; DNA; DNA Damage; Free Radicals; Insulin; Insulin Secretion; Interleukin-1; Islets of Langerhans; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Vasodilator Agents | 1994 |
Functional relationship between cyclic AMP-dependent protein phosphorylation and platelet inhibition.
Topics: Amino Acid Sequence; Blood Platelets; Blood Proteins; Calcium; Cyclic AMP; GTP-Binding Proteins; Humans; Iloprost; Molecular Sequence Data; Molsidomine; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Phosphorylation; Platelet Activation; Prostaglandins; Protein Processing, Post-Translational; rap GTP-Binding Proteins; Signal Transduction; Vasodilator Agents | 1993 |
Nitric oxide donor, linsidomine chlorhydrate (SIN-1), in the diagnosis and treatment of erectile dysfunction: critical appraisal and review of the literature.
Topics: Animals; Erectile Dysfunction; Humans; Male; Molsidomine; Vasodilator Agents | 1995 |
Modulation of acetylcholine release by nitric oxide.
Topics: Acetylcholine; Animals; Brain; Central Nervous System; Digestive System; Enzyme Inhibitors; Humans; Molsidomine; Myenteric Plexus; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine | 1996 |
[Pharmacological therapy in erectile dysfunction--current standards and new viewpoint].
Topics: Alprostadil; Dosage Forms; Enzyme Inhibitors; Erectile Dysfunction; Humans; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth; Penile Erection; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Testosterone; Vasodilator Agents | 1997 |
Involvement and dual effects of nitric oxide in septic shock.
Topics: Animals; Electrochemistry; Electron Spin Resonance Spectroscopy; Enzyme Induction; Enzyme Inhibitors; Lipopolysaccharides; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Shock, Septic | 1998 |
Nitric oxide donors.
Topics: Animals; Aspirin; Drug Tolerance; Heart; Humans; In Vitro Techniques; Molsidomine; Myocardial Infarction; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Nitroprusside; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Superoxides; Triazenes | 2000 |
[Mechanism of gastric mucosal cell injury induced by reactive oxygen species and nitric oxide].
Topics: Animals; Gastric Mucosa; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Molsidomine; Nitric Oxide; Oxidative Stress; Reactive Oxygen Species | 2002 |
Use of recombinant iron-superoxide dismutase as a marker of nitrative stress.
Topics: Antibodies; Biomarkers; Enzyme Activation; Immunohistochemistry; Molsidomine; Nitro Compounds; Nitrosation; Oxidative Stress; Recombinant Proteins; Serum Albumin, Bovine; Superoxide Dismutase; Tyrosine | 2008 |
[The pharmacology of nitric oxide and nitrates].
Topics: Animals; Humans; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Vasodilator Agents | 2010 |
34 trial(s) available for linsidomine and molsidomine
| Article | Year |
|---|---|
Specific coronary hemodynamic effects of nisoldipine and other vasoactive drugs.
Topics: Angioplasty, Balloon, Coronary; Coronary Circulation; Coronary Vessels; Diltiazem; Double-Blind Method; Echocardiography, Doppler; Female; Humans; Male; Molsidomine; Nisoldipine; Vasodilator Agents | 1992 |
[Acute hemodynamic effects of SIN-1 and isosorbide dinitrate in stable left ventricular failure: a comparative double-blind, cross-over study].
Topics: Adult; Aged; Aged, 80 and over; Cardiac Output, Low; Double-Blind Method; Female; Hemodynamics; Humans; Male; Middle Aged; Molsidomine; Vasodilator Agents | 1992 |
The effects of the nitric oxide donors molsidomine and SIN-I on human polymorphonuclear leucocyte function in vitro and ex vivo.
Topics: Adult; Double-Blind Method; Glucuronidase; Humans; Male; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Superoxides; Vasodilator Agents | 1992 |
Pharmacokinetics of molsidomine and its active metabolite, linsidomine, in patients with liver cirrhosis.
Topics: Adult; Humans; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Molsidomine; Reference Values | 1991 |
[Comparative study of the vasodilator properties of linsidomine chlorhydrate versus isosorbide dinitrate by the intracoronary route].
Topics: Adult; Aged; Angina Pectoris; Female; Humans; Injections, Intra-Arterial; Isosorbide Dinitrate; Male; Middle Aged; Molsidomine; Prospective Studies; Vasodilator Agents | 1991 |
[Acute and chronic effects of molsidomine in therapeutic coronary angioplasty].
Topics: Angioplasty, Balloon, Coronary; Coronary Circulation; Coronary Disease; Delayed-Action Preparations; Electrocardiography; Follow-Up Studies; Humans; Molsidomine; Prospective Studies; Randomized Controlled Trials as Topic; Recurrence; Vasodilator Agents | 1990 |
Hemodynamic effects of SIN-1 in acute left heart failure.
Topics: Aged; Dose-Response Relationship, Drug; Female; Heart Failure; Hemodynamics; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Middle Aged; Molsidomine; Time Factors; Vasodilator Agents; Ventricular Function, Left | 1989 |
[SIN-1 in intracoronary administration].
Topics: Blood Circulation; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Circulation; Coronary Vessels; Drug Tolerance; Heart Rate; Humans; Injections, Intra-Arterial; Molsidomine; Nitroglycerin; Vasodilation | 1988 |
Exercise-induced angina alleviated by intracoronary SIN-1.
Topics: Adult; Aged; Angina Pectoris; Coronary Vessels; Exercise Test; Hemodynamics; Humans; Injections, Intra-Arterial; Male; Middle Aged; Molsidomine; Vasodilator Agents | 1987 |
Active and passive changes in coronary diameter after vasodilation with SIN-1, the active metabolite of molsidomine.
Topics: Coronary Angiography; Coronary Vasospasm; Coronary Vessels; Humans; Molsidomine; Oxadiazoles; Sydnones; Time Factors; Vasodilator Agents | 1985 |
[Dynamics of critical stenosis in patients with unstable angina pectoris].
Topics: Angina Pectoris; Angina, Unstable; Coronary Angiography; Coronary Circulation; Coronary Disease; Hemodynamics; Humans; Isosorbide Dinitrate; Molsidomine; Myocardial Infarction; Nifedipine; Nitroglycerin; Sydnones | 1984 |
[Diameter changes of epicardial coronary arteries and coronary stenoses after intracoronary application of SIN 1, a molsidomine metabolite].
Topics: Coronary Disease; Coronary Vessels; Double-Blind Method; Humans; Injections, Intra-Arterial; Molsidomine; Oxadiazoles; Random Allocation; Sydnones; Vasodilator Agents | 1983 |
Hemodynamics, tolerability, and pharmacokinetics of linsidomine (SIN-1) infusion during the acute phase of uncomplicated myocardial infarction.
Topics: Adult; Aged; Blood Pressure; Cardiac Output; Female; Heart Rate; Hemodynamics; Humans; Infusions, Intravenous; Male; Middle Aged; Molsidomine; Myocardial Infarction; Vasodilator Agents | 1993 |
Isosorbidedinitrate and SIN-1 as dilators of human coronary arteries and platelet inhibitors.
Topics: Angina Pectoris; Blood Pressure; Coronary Vessels; Cyclic AMP; Cyclic GMP; Double-Blind Method; Female; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Molsidomine; Platelet Aggregation; Platelet Aggregation Inhibitors; Vasodilator Agents | 1995 |
Prostaglandin E1 versus linsidomine chlorhydrate in erectile dysfunction.
Topics: Adult; Aged; Aged, 80 and over; Alprostadil; Cross-Over Studies; Erectile Dysfunction; Humans; Male; Medical History Taking; Middle Aged; Molsidomine; Single-Blind Method; Time Factors; Treatment Outcome; Vasodilator Agents | 1994 |
The ESPRIM trial: short-term treatment of acute myocardial infarction with molsidomine. European Study of Prevention of Infarct with Molsidomine (ESPRIM) Group.
Topics: Administration, Oral; Double-Blind Method; Female; Hospital Mortality; Humans; Infusions, Intravenous; Male; Middle Aged; Molsidomine; Myocardial Infarction; Placebos; Proportional Hazards Models; Survival Analysis; Treatment Outcome; Vasodilator Agents | 1994 |
Role of the nitric oxide donor linsidomine chlorhydrate (SIN-1) in the diagnosis and treatment of erectile dysfunction.
Topics: Adult; Aged; Drug Therapy, Combination; Electromyography; Erectile Dysfunction; Follow-Up Studies; Humans; Injections; Male; Middle Aged; Molsidomine; Papaverine; Penile Erection; Phentolamine; Self Administration; Vasodilator Agents | 1994 |
[Coronary dilatation after intracoronary administration of SIN-1 and intravenous molsidomine administration].
Topics: Adult; Aged; Angina Pectoris; Coronary Circulation; Coronary Disease; Coronary Vessels; Double-Blind Method; Female; Hemodynamics; Humans; Infusions, Intravenous; Male; Middle Aged; Molsidomine; Vasodilator Agents | 1994 |
Meeting highlights: nitric oxide donors.
Topics: Angioplasty, Balloon, Coronary; Coronary Disease; Diltiazem; Humans; Isosorbide Dinitrate; Molsidomine; Nitric Oxide; Vasodilator Agents | 1994 |
SIN-1 has no direct myocardial anti-ischemic action.
Topics: Angioplasty, Balloon, Coronary; Coronary Circulation; Coronary Disease; Double-Blind Method; Electrocardiography; Female; Hemodynamics; Humans; Male; Middle Aged; Molsidomine; Myocardial Ischemia; Vasodilator Agents | 1993 |
[Effects of intracoronary injection of SIN-1 on vasoconstriction of epicardial arteries induced by acetylcholine].
Topics: Acetylcholine; Aged; Clinical Protocols; Coronary Vessels; Female; Humans; Injections, Intra-Arterial; Male; Middle Aged; Molsidomine; Pericardium; Vasoconstriction; Vasodilator Agents | 1993 |
Pharmacokinetics of linsidomine (SIN 1) after single and multiple intravenous short infusions in patients with renal insufficiency.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Coronary Disease; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Kidney; Male; Middle Aged; Molsidomine; Renal Insufficiency; Vasodilator Agents | 1993 |
Prostaglandin E1 and the nitric oxide donor linsidomine for erectile failure: a diagnostic comparative study of 40 patients.
Topics: Adult; Aged; Alprostadil; Blood Flow Velocity; Erectile Dysfunction; Humans; Male; Middle Aged; Molsidomine; Penile Erection; Vasodilator Agents | 1993 |
Efficacy of linsidomine chlorhydrate, a direct nitric oxide donor, in the treatment of human erectile dysfunction: results of a double-blind cross over trial.
Topics: Adult; Aged; Alprostadil; Cross-Over Studies; Double-Blind Method; Humans; Male; Middle Aged; Molsidomine; Nitric Oxide; Penile Diseases; Penile Erection; Piperazines; Vasodilator Agents | 1995 |
[Linsidomine, direct donor of EDRF/NO: a new treatment for unstable angina].
Topics: Adult; Aged; Angina, Unstable; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Hemodynamics; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Molsidomine; Myocardial Infarction; Nitric Oxide; Prospective Studies; Vasodilator Agents | 1996 |
Effect of the direct nitric oxide donors linsidomine and molsidomine on angiographic restenosis after coronary balloon angioplasty. The ACCORD Study. Angioplastic Coronaire Corvasal Diltiazem.
Topics: Aged; Angioplasty, Balloon, Coronary; Coronary Angiography; Coronary Disease; Coronary Vessels; Diltiazem; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Molsidomine; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Treatment Outcome; Vasodilator Agents | 1997 |
Lack of cross-tolerance to short-term linsidomine in forearm resistance vessels and dorsal hand veins in subjects with nitroglycerin tolerance.
Topics: Adult; Analysis of Variance; Blood Pressure; Confounding Factors, Epidemiologic; Double-Blind Method; Drug Tolerance; Forearm; Heart Rate; Humans; Molsidomine; Nitroglycerin; Reference Values; Time Factors; Vascular Resistance; Vasodilator Agents | 1997 |
Comparative efficacy of the intravenous administration of linsidomine, a direct nitric oxide donor, and isosorbide dinitrate in severe unstable angina. A French multicentre study. French Group of Investigators.
Topics: Aged; Angina, Unstable; Confidence Intervals; Electrocardiography, Ambulatory; Female; France; Humans; Isosorbide Dinitrate; Male; Middle Aged; Molsidomine; Nitric Oxide; Prospective Studies; Single-Blind Method; Statistics, Nonparametric; Treatment Outcome; Vasodilator Agents | 1997 |
Differential inhibition of human platelet aggregation and thromboxane A2 formation by L-arginine in vivo and in vitro.
Topics: Adult; Antithrombins; Arginine; Blood Platelets; Cyclic GMP; Enzyme Inhibitors; Humans; In Vitro Techniques; Infusions, Intravenous; Male; Molsidomine; Nitric Oxide Synthase; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane A2; Thromboxane B2; Thromboxanes | 1998 |
Oxidation and antioxidation of human low-density lipoprotein and plasma exposed to 3-morpholinosydnonimine and reagent peroxynitrite.
Topics: Adenosine Triphosphatases; Adult; Antioxidants; Enzyme Inhibitors; Female; Humans; Lipoproteins, LDL; Male; Mass Spectrometry; Molsidomine; Nitrates; Oxidants; Oxidation-Reduction; Plasma; Ubiquinone; Vitamin E | 1998 |
Effect of topical vasodilators on gastroepiploic artery graft.
Topics: Administration, Topical; Aged; Arteries; Coronary Artery Bypass; Double-Blind Method; Female; Hemodynamics; Humans; Intraoperative Period; Male; Middle Aged; Molsidomine; Nicardipine; Nitroglycerin; Papaverine; Regional Blood Flow; Stomach; Vasodilator Agents | 1999 |
[Transradial approach for diagnostic angiography].
Topics: Angiography; Anticoagulants; Catheterization, Peripheral; Drug Combinations; Female; Femoral Artery; Hematoma; Heparin; Humans; Injections, Intravenous; Male; Middle Aged; Molsidomine; Patient Selection; Radial Artery; Risk Factors; Vasodilator Agents; Verapamil | 2004 |
Coronary vasomotor response to the selective B1-kinin-receptor agonist Des-Arg9-bradykinin in humans.
Topics: Acetylcholine; Adult; Blood Flow Velocity; Bradykinin; Coronary Angiography; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Heart Transplantation; Hemodynamics; Humans; Male; Middle Aged; Molsidomine; Muscle, Smooth, Vascular; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Vasoconstriction; Vasodilation; Vasodilator Agents | 2006 |
Postconditioning attenuates myocardial injury by reducing nitro-oxidative stress in vivo in rats and in humans.
Topics: Aged; Angioplasty, Balloon, Coronary; Animals; Apoptosis; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Ischemic Postconditioning; Leukocyte Count; Male; Malondialdehyde; Middle Aged; Molsidomine; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Sprague-Dawley; Treatment Outcome; Tyrosine; Ventricular Function, Left | 2011 |
1338 other study(ies) available for linsidomine and molsidomine
| Article | Year |
|---|---|
Prostacyclin rather than nitric oxide lowers human umbilical artery tone in vitro.
Topics: Arginine; Bradykinin; Cyclic GMP; Epoprostenol; Female; Histamine; Humans; Iloprost; In Vitro Techniques; Indomethacin; Molsidomine; Muscle Contraction; Nitric Oxide; Nitroarginine; Serotonin; Umbilical Arteries; Vasodilation | 1992 |
Differential effects of nitrovasodilators, K(+)-channel openers, and nicorandil on large and small coronary arteries in conscious dogs.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Injections, Intravenous; Molsidomine; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilation; Vasodilator Agents | 1992 |
Endothelium-dependent relaxations are augmented in rats chronically treated with the angiotensin-converting enzyme inhibitor enalapril.
Topics: Acetylcholine; Adenosine Diphosphate; Angiotensin II; Animals; Aorta, Thoracic; Enalapril; Endothelium, Vascular; Male; Molsidomine; Phenylephrine; Rats; Rats, Wistar; Vasoconstriction; Vasodilation; Vasodilator Agents | 1992 |
Exogenous nitric oxide stress on endothelial cells and macrophages.
Topics: Amino Acid Oxidoreductases; Animals; Aorta; Calcimycin; Cattle; Cells, Cultured; Down-Regulation; Endothelium, Vascular; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Sydnones; Vasodilator Agents | 1992 |
Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets.
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Calcium; Cell Compartmentation; Cyclic GMP; Cytoplasm; Humans; In Vitro Techniques; Ion Channel Gating; Kinetics; Molsidomine; Nitroprusside; Phosphoproteins; Protein Kinases; Receptors, Cell Surface; Thrombin; Vasodilator Agents | 1992 |
Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide.
Topics: Benzoates; Benzoic Acid; Deoxyribose; Ethanol; Free Radical Scavengers; Free Radicals; Hydroxides; Hydroxyl Radical; Kinetics; Malondialdehyde; Molsidomine; Nitric Oxide; Oxidation-Reduction; Superoxides | 1992 |
Effect of 3-morpholinosydnonimine (SIN-1) and NG-nitro-L-arginine (NNA) on isolated perfused anaphylactic guinea-pig hearts.
Topics: 6-Ketoprostaglandin F1 alpha; Anaphylaxis; Animals; Antihypertensive Agents; Arginine; Coronary Circulation; Guinea Pigs; Heart; Leukotriene B4; Male; Molsidomine; Nitroarginine; Perfusion; Thromboxane B2; Vasodilator Agents | 1992 |
Nitric oxide-induced blockade of NMDA receptors.
Topics: Animals; Calcium; Cyclic GMP; In Vitro Techniques; Mice; Molsidomine; N-Methylaspartate; N-Nitrosopyrrolidine; Nitric Oxide; Nitroso Compounds; Receptors, N-Methyl-D-Aspartate; Sodium Nitrite | 1992 |
Nitrovasodilators inhibit thrombin-induced platelet-activating factor synthesis in human endothelial cells.
Topics: Acetyltransferases; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Humans; Molsidomine; Nitroprusside; Platelet Activating Factor; Thrombin | 1992 |
Molsidomine inhibits the chemoattractant-induced respiratory burst in human neutrophils via a no-independent mechanism.
Topics: Acetates; Acetic Acid; Calcium; Cell Membrane; Cell-Free System; Cytosol; Dose-Response Relationship, Drug; Drug Interactions; GTP Phosphohydrolases; Humans; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitric Oxide; Oxygen Consumption; Respiratory Burst; Superoxides; Tumor Cells, Cultured | 1992 |
L-cysteine augments the vasorelaxation induced by sodium nitrite and SIN-1 but not that due to acetylcholine.
Topics: Acetylcholine; Animals; Cyclic GMP; Cysteine; Drug Synergism; Endothelium, Vascular; In Vitro Techniques; Male; Mesenteric Arteries; Molsidomine; Nitric Oxide; Rats; Rats, Inbred Strains; Sodium Nitrite; Vasodilation | 1992 |
Pharmacological interaction experiments differentiate between glibenclamide-sensitive K+ channels and cyclic GMP as components of vasodilation by nicorandil.
Topics: Animals; Benzopyrans; Cattle; Coronary Vessels; Cromakalim; Cyclic GMP; Drug Interactions; Glyburide; Guanidines; In Vitro Techniques; Methylene Blue; Molsidomine; Muscle Relaxation; Niacinamide; Nicorandil; Nitroprusside; Pinacidil; Potassium Channels; Pyrroles; Sensitivity and Specificity; Vasodilator Agents | 1992 |
Characterization of inhibitory neurotransmission in the isolated corpus cavernosum from rabbit and man.
Topics: Animals; Arginine; Electric Stimulation; Humans; Male; Molsidomine; Muscle Contraction; Muscle Relaxation; Nitric Oxide; Nitroarginine; Penis; Rabbits; Synaptic Transmission; Vasodilator Agents | 1992 |
The participation of nitric oxide in cell free- and its restriction of macrophage-mediated oxidation of low-density lipoprotein.
Topics: Animals; Antioxidants; Cell-Free System; Cells, Cultured; Endocytosis; Free Radicals; Humans; Lipoproteins, LDL; Macrophages; Mice; Molsidomine; Nitric Oxide; Nitrites; Oxidation-Reduction; Peritoneal Cavity; Superoxides | 1992 |
Inhibition of platelet arachidonic acid liberation by endothelium-derived relaxing factor (EDRF) as studied with sin-1, a nitric oxide generating drug. Evidence for calcium-dependent and calcium-independent mechanisms.
Topics: Arachidonic Acid; Blood Platelets; Calcium; Cyclic GMP; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Molsidomine; Nitric Oxide; Phospholipases A; Phospholipases A2; Thrombin | 1992 |
Modulation of the pharmacological actions of nitrovasodilators by methylene blue and pyocyanin.
Topics: Animals; Aorta; Cyclic GMP; Drug Interactions; In Vitro Techniques; Methylene Blue; Molsidomine; Nitric Oxide; Nitroglycerin; Nitroprusside; Penicillamine; Platelet Aggregation; Pyocyanine; Rabbits; S-Nitroso-N-Acetylpenicillamine; Sodium Nitrite; Vasodilator Agents | 1992 |
The simultaneous generation of superoxide and nitric oxide can initiate lipid peroxidation in human low density lipoprotein.
Topics: Antioxidants; Catalase; Humans; Lipid Peroxidation; Lipoproteins, LDL; Molecular Structure; Molsidomine; Nitric Oxide; Nitroprusside; Oxygen Consumption; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Superoxide Dismutase; Superoxides; Time Factors | 1992 |
The molecular mechanism of central analgesia induced by morphine or carbachol and the L-arginine-nitric oxide-cGMP pathway.
Topics: Analgesia; Animals; Arginine; Brain; Carbachol; Cyclic GMP; Dinoprostone; Male; Molsidomine; Morphine; Nitric Oxide; Ornithine; Phthalazines; Rats; Rats, Wistar | 1992 |
Role of the L-arginine-NO pathway and of cyclic GMP in electrical field-induced noradrenaline release and vasoconstriction in the rat tail artery.
Topics: Animals; Arginine; Arteries; Atrial Natriuretic Factor; Cyclic GMP; Electric Stimulation; Endothelium, Vascular; In Vitro Techniques; Male; Methylene Blue; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Purinones; Rats; Tail; Vasoconstriction; Vasodilator Agents | 1992 |
Total prevention of the development of in vitro tolerance to organic nitrates. Experiments with antioxidants.
Topics: Animals; Antioxidants; Aorta, Thoracic; Drug Tolerance; Female; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Muscle Relaxation; Nitrates; Nitroglycerin; Parasympatholytics; Rabbits; Vasodilator Agents | 1992 |
Exogenous modification of nitrovasodilator-induced cyclic GMP formation in human lymphocytes.
Topics: Chromans; Cyclic GMP; Cysteine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylate Cyclase; Humans; L-Lactate Dehydrogenase; Lymphocytes; Molsidomine; Nitroprusside; Vasodilator Agents | 1992 |
Nitric oxide-releasing compounds inhibit Dictyostelium discoideum aggregation without altering cGMP production.
Topics: Animals; Antihypertensive Agents; Cyclic AMP; Cyclic GMP; Dictyostelium; Guanylate Cyclase; Molsidomine; Morphogenesis; Nitric Oxide; Nitroprusside; Vasodilator Agents | 1992 |
Inhibitors of calmodulin impair the constitutive but not the inducible nitric oxide synthase activity in the rat aorta.
Topics: Amino Acid Oxidoreductases; Animals; Aorta; Arginine; Calmodulin; Cyclic GMP; Drug Interactions; Endothelium, Vascular; Fendiline; Imidazoles; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Inbred Strains; Vasodilator Agents | 1992 |
Nitric oxide releases acetylcholine in the basal forebrain.
Topics: Acetylcholine; Amino Acid Oxidoreductases; Animals; Arginine; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Prosencephalon; Rats | 1992 |
Effect of prostaglandin E2 and 3-morpholinosydnonimine (SIN-1) on arachidonic acid metabolism in fMLP-stimulated rat neutrophils and on thrombin-induced human platelet aggregation.
Topics: Animals; Arachidonic Acid; Dinoprostone; Exudates and Transudates; Humans; In Vitro Techniques; Leukotrienes; Male; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Thrombin | 1992 |
Effects of inhibition of the L-arginine/nitric oxide pathway in the rat lower urinary tract in vivo and in vitro.
Topics: Animals; Arginine; Electric Stimulation; Female; In Vitro Techniques; Molsidomine; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Rats; Rats, Sprague-Dawley; Urethra; Urinary Bladder; Urinary Tract; Urinary Tract Physiological Phenomena; Urination; Vasodilator Agents | 1992 |
Preliminary results with the nitric oxide donor linsidomine chlorhydrate in the treatment of human erectile dysfunction.
Topics: Blood Flow Velocity; Dose-Response Relationship, Drug; Erectile Dysfunction; Humans; Male; Molsidomine; Nitric Oxide; Penile Erection; Penis; Vasodilator Agents | 1992 |
Role of the L-arginine-nitric oxide pathway in the changes in cerebrovascular reactivity following hemorrhagic hypotension and retransfusion.
Topics: Acetylcholine; Animals; Arginine; Cats; Cerebral Arteries; Endothelium, Vascular; Male; Molsidomine; Muscle, Smooth, Vascular; Nitroarginine; Norepinephrine; Reperfusion; Shock, Hemorrhagic; Vasodilation | 1992 |
Exogenous nitric oxide inhibits in vivo platelet adhesion following balloon angioplasty.
Topics: Angioplasty, Balloon; Animals; Blood Platelets; Carotid Arteries; Endothelium, Vascular; Molsidomine; Nitric Oxide; Platelet Adhesiveness; Postoperative Period; Swine | 1992 |
Inhibition by L-NG-nitro-L-arginine of nonadrenergic-noncholinergic-mediated relaxations of human isolated central and peripheral airway.
Topics: Arginine; Bronchi; Chymotrypsin; Electric Stimulation; Humans; In Vitro Techniques; Molsidomine; Muscle Relaxation; Nitroarginine; Stereoisomerism; Vasoactive Intestinal Peptide; Vasodilator Agents | 1992 |
Characterization of endothelium-dependent relaxations resistant to nitro-L-arginine in the porcine coronary artery.
Topics: Animals; Arginine; Bradykinin; Coronary Vessels; Dinoprost; Endothelium, Vascular; In Vitro Techniques; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Swine; Vasodilation; Vasodilator Agents | 1992 |
Similar endothelium-dependent relaxation, but enhanced contractility, of the right gastroepiploic artery as compared with the internal mammary artery.
Topics: Acetylcholine; Arteries; Coronary Artery Bypass; Endothelium, Vascular; Histamine; Humans; Mammary Arteries; Molsidomine; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Omentum; Potassium Chloride; Stomach; Vasodilator Agents | 1992 |
Nitric oxide causes ADP-ribosylation and inhibition of glyceraldehyde-3-phosphate dehydrogenase.
Topics: Adenosine Diphosphate Ribose; Blood Platelets; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Kinetics; Molecular Weight; Molsidomine; NAD; Nitric Oxide; Vasodilator Agents | 1992 |
Nitrovasodilators as a new class of ocular hypotensive agents.
Topics: Administration, Topical; Animals; Aqueous Humor; Atrial Natriuretic Factor; Blood Pressure; Dose-Response Relationship, Drug; Intraocular Pressure; Isosorbide Dinitrate; Male; Molsidomine; Nitroglycerin; Nitroprusside; Rabbits; Vasodilator Agents | 1992 |
The effects of linsidomine on portal hypertension.
Topics: Animals; Hypertension, Portal; Molsidomine; Portal System; Rats; Regional Blood Flow; Vascular Resistance; Vasodilator Agents | 1992 |
Effect of 3-morpholinosydnonimine (SIN-1), NG-nitro-L-arginine (NNA) and NG-monomethyl-L-arginine (NMMA) on isolated anaphylactic guinea-pig hearts.
Topics: Anaphylaxis; Animals; Arginine; Coronary Circulation; Eicosanoids; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Male; Molsidomine; Myocardium; Nitroarginine; omega-N-Methylarginine; Ovalbumin | 1992 |
The impairment of endothelium-dependent relaxations in reversed vein grafts is associated with a reduced production of cyclic guanosine monophosphate.
Topics: Acetylcholine; Animals; Carotid Arteries; Cyclic GMP; Endothelium, Vascular; Hemoglobins; In Vitro Techniques; Jugular Veins; Male; Molsidomine; Muscle Relaxation; Nitric Oxide; Rabbits; Vasodilator Agents; Veins | 1991 |
Inactivation of ribonucleotide reductase by nitric oxide.
Topics: Animals; Cell Line; Cytosol; Electron Spin Resonance Spectroscopy; Glutathione; Kinetics; Mammary Neoplasms, Experimental; Molsidomine; Nitric Oxide; Nitroprusside; Nitroso Compounds; Oxyhemoglobins; Ribonucleotide Reductases; S-Nitrosoglutathione; Superoxide Dismutase; Vasodilator Agents; Xanthine Oxidase | 1991 |
Comparative effects of some nitric oxide donors on cyclic GMP levels in rat cerebellar slices.
Topics: Animals; Cerebellum; Cyclic GMP; Hydroxylamine; Hydroxylamines; In Vitro Techniques; Molsidomine; Nitric Oxide; Nitroprusside; Penicillamine; Rats; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents | 1991 |
The molecular mechanism of action of peripheral morphine analgesia: stimulation of the cGMP system via nitric oxide release.
Topics: Analgesia; Animals; Arginine; Cyclic GMP; Male; Methylene Blue; Molsidomine; Morphine; Nitric Oxide; Ornithine; Phthalazines; Rats; Rats, Inbred Strains | 1991 |
On-line detection of nitric oxide formation in liquid aqueous phase by electron paramagnetic resonance spectroscopy.
Topics: Electron Spin Resonance Spectroscopy; Indicators and Reagents; Kinetics; Molsidomine; Nitric Oxide; Nitrites; Saccharomyces cerevisiae | 1991 |
Molecular mechanisms of nitrovasodilator bioactivation.
Topics: Amyl Nitrite; Enzyme Activation; Guanylate Cyclase; Isosorbide Dinitrate; Methemoglobin; Molsidomine; Nitrates; Nitric Oxide; Nitroglycerin; Nitroprusside; Oxyhemoglobins | 1991 |
Intercellular action of nitric oxide in adult rat cerebellar slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebellum; Cyclic GMP; Drug Interactions; Glutamates; Glutamic Acid; Hemoglobins; Hydroxylamine; Hydroxylamines; Ibotenic Acid; Kainic Acid; Molsidomine; N-Methylaspartate; Nitric Oxide; Nitroprusside; Penicillamine; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; S-Nitroso-N-Acetylpenicillamine | 1991 |
Selective blockade of N-methyl-D-aspartate receptor function by the nitric oxide donor, nitroprusside.
Topics: Action Potentials; Animals; Cerebellum; Glutamates; Glutamic Acid; Molsidomine; N-Methylaspartate; Nitric Oxide; Nitroprusside; Penicillamine; Rats; Receptors, N-Methyl-D-Aspartate; S-Nitroso-N-Acetylpenicillamine; Stimulation, Chemical; Synapses | 1991 |
Nitrate tolerance induced by nicorandil or nitroglycerin is associated with minimal loss of nicorandil vasodilator activity.
Topics: Animals; Arteries; Cattle; Coronary Vessels; Drug Tolerance; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrates; Nitric Oxide; Nitroglycerin; Vasodilator Agents | 1990 |
Cyclic GMP mediates SIN-1-induced inhibition of human polymorphonuclear leukocytes.
Topics: 1-Methyl-3-isobutylxanthine; Cyanides; Cyclic AMP; Cyclic GMP; Glucuronidase; Humans; In Vitro Techniques; Macrophage Activation; Methylene Blue; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitroglycerin; Nitroprusside; Nitrosamines; Vasodilator Agents | 1990 |
Effects of in vivo SIN1 treatment on nitrovasodilator relaxation and on EDRF-mediated responses in rat aorta.
Topics: Animals; Aorta, Thoracic; Drug Evaluation, Preclinical; Drug Tolerance; Enzyme Activation; Guanylate Cyclase; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Rats; Rats, Inbred Strains; Vasodilator Agents | 1990 |
Inhibition of coronary artery thrombosis by SIN-1, a donor of nitric oxide.
Topics: Animals; Coronary Thrombosis; Dogs; Drug Evaluation, Preclinical; Female; Hemodynamics; Male; Molsidomine; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Vasodilator Agents | 1990 |
Effects of nitrovasodilators on platelet cyclic nucleotide levels in rabbit blood; role for cyclic AMP in synergistic inhibition of platelet function by SIN-1 and prostaglandin E1.
Topics: Alprostadil; Animals; Blood Platelets; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Epoprostenol; Male; Molsidomine; Nitric Oxide; Purinones; Rabbits; Serotonin; Vasodilator Agents | 1991 |
Reduced nitric oxide release causes nitrate tolerance in the intact coronary circulation.
Topics: Animals; Bradykinin; Cell Line; Coronary Vessels; Cyclic GMP; Drug Tolerance; Fibroblasts; Heart; Iloprost; Lung; Molsidomine; Myocardium; Nitrates; Nitric Oxide; Nitroglycerin; Rabbits; Rats; Vasodilator Agents | 1991 |
The effect of nitric oxide generators on ischemia reperfusion injury and histamine release in isolated perfused guinea-pig heart.
Topics: Animals; Arginine; Calcium; Coronary Vessels; Cytoplasmic Granules; Guinea Pigs; Histamine Release; Male; Mast Cells; Molsidomine; Myocardial Reperfusion Injury; Nitric Oxide; Nitroprusside; omega-N-Methylarginine | 1991 |
Effect of carbenoxolone on the biological activity of nitric oxide: relation to gastroprotection.
Topics: Animals; Aorta; Arginine; Carbenoxolone; Gastric Mucosa; Humans; Iloprost; In Vitro Techniques; Male; Methylene Blue; Molsidomine; Muscle Relaxation; Muscle Tonus; Neutrophils; Nitric Oxide; Nitroarginine; Nitroprusside; Oxyhemoglobins; Rats; Rats, Inbred Strains; Stomach Ulcer; Vasodilator Agents | 1991 |
Modification of nitrovasodilator effects on vascular smooth muscle by exogenous GTP and guanosine.
Topics: Animals; Cyclic GMP; Guanosine; Guanosine Triphosphate; In Vitro Techniques; Male; Molsidomine; Muscle, Smooth, Vascular; Nitroglycerin; Rats; Rats, Inbred Strains; Sodium Nitrite; Vasodilation | 1991 |
Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Calcimycin; Cats; Endothelium, Vascular; Hemodynamics; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Reperfusion Injury; Nitric Oxide; Prostaglandin Endoperoxides, Synthetic; Sydnones; Vasodilator Agents | 1992 |
The nitric oxide donor SIN-1 is a potent inhibitor of plasminogen activator inhibitor release from stimulated platelets.
Topics: Blood Platelets; Humans; Molsidomine; Nitric Oxide; Plasminogen Inactivators; Platelet Aggregation Inhibitors | 1991 |
[Effect of SIN 1 on the interactions of endothelial cells and thrombocytes].
Topics: Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Molsidomine; Platelet Aggregation; Platelet Aggregation Inhibitors | 1991 |
[Interaction between thrombocytes and the coronary system in the presence of SIN 1 and nitroglycerin after endothelial damage].
Topics: Animals; Blood Platelets; Coronary Circulation; Coronary Thrombosis; Endothelium, Vascular; Models, Cardiovascular; Molsidomine; Myocardial Reperfusion; Nitroglycerin; Platelet Aggregation Inhibitors; Rabbits; Vasodilator Agents | 1991 |
[Platelet aggregation with SIN 1: comparison with isosorbide-5-mononitrate and acetylsalicylic acid].
Topics: Aspirin; Dose-Response Relationship, Drug; Humans; Isosorbide Dinitrate; Molsidomine; Platelet Aggregation; Platelet Aggregation Inhibitors; Vasodilator Agents | 1991 |
The L-arginine-nitric oxide pathway in the canine femoral vascular bed: in vitro and in vivo experiments.
Topics: Acetylcholine; Animals; Arginine; Blood Flow Velocity; Blood Pressure; Bradykinin; Dogs; Drug Interactions; Endothelium, Vascular; Female; Femoral Artery; Heart Rate; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Vasodilation; Vasodilator Agents | 1991 |
Effect of aging and hypertension on endothelial function of rat coronary arteries.
Topics: Acetylcholine; Aging; Animals; Coronary Vessels; Endothelium, Vascular; In Vitro Techniques; Male; Molsidomine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Serotonin; Vasoconstriction; Vasodilation; Vasodilator Agents | 1991 |
Osteoclastic inhibition: an action of nitric oxide not mediated by cyclic GMP.
Topics: Animals; Animals, Newborn; Bone Resorption; Calcitonin; Calcium; Cell Membrane; Cells, Cultured; Cyclic GMP; Cytosol; Dibutyryl Cyclic GMP; Ionomycin; Kinetics; Molsidomine; Nitric Oxide; Osteoclasts; Rats; Rats, Inbred Strains; Vasodilator Agents | 1991 |
Synergistic actions of nitrovasodilators and isoprenaline on rat aortic smooth muscle.
Topics: Adenylyl Cyclases; Animals; Aorta; Dose-Response Relationship, Drug; Drug Synergism; In Vitro Techniques; Isoproterenol; Male; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Quinolones; Rats; Rats, Inbred Strains; Vasodilator Agents | 1991 |
Generation of nitric oxide from organic nitrovasodilators during passage through the coronary vascular bed and its role in coronary vasodilation and nitrate tolerance.
Topics: Animals; Arginine; Coronary Vessels; Drug Tolerance; Molsidomine; Nitric Oxide; Nitroglycerin; omega-N-Methylarginine; Rabbits; Trypsin; Vasodilation; Vasodilator Agents | 1991 |
Effect of nitrate tolerance and dipyridamole on the response to SIN1 in the human isolated saphenous vein.
Topics: Dipyridamole; Drug Tolerance; Humans; In Vitro Techniques; Molsidomine; Nitroglycerin; Saphenous Vein; Serotonin; Vasodilator Agents | 1991 |
Effect of the molsidomine metabolite SIN-1 on coronary arteries and peripheral vessels of sheep with special reference to tolerance and endothelium.
Topics: Animals; Blood Vessels; Coronary Vessels; Dose-Response Relationship, Drug; Drug Tolerance; Endothelium; Femoral Artery; Femoral Vein; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Nitric Oxide; Nitroglycerin; Sheep; Vasodilator Agents | 1991 |
Pharmacokinetics of molsidomine and of its active metabolite, SIN-1 (or linsidomine), in the elderly.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Male; Molsidomine | 1991 |
Nitrovasodilator-induced inhibition of LTB4 release from human PMN may be mediated by cyclic GMP.
Topics: Cyclic GMP; Humans; Leukotriene B4; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitroglycerin; Nitrosamines; Vasodilator Agents | 1990 |
L-arginine evokes both endothelium-dependent and -independent relaxations in L-arginine-depleted aortas of the rat.
Topics: Acetylcholine; Amino Acids; Animals; Aorta; Arginine; Endothelium, Vascular; Male; Molsidomine; Nitric Oxide; Phenylephrine; Rats; Rats, Inbred Strains; Vasodilation; Vasodilator Agents | 1991 |
Torsades de pointes after intracoronary papaverine.
Topics: Angioplasty, Balloon, Coronary; Blood Flow Velocity; Coronary Circulation; Coronary Disease; Electrocardiography; Hemodynamics; Humans; Injections; Male; Middle Aged; Molsidomine; Papaverine; Torsades de Pointes; Vasodilator Agents | 1991 |
Influence of no-donor (SIN-1) on functions of inflammatory cells.
Topics: Animals; Glucuronidase; Humans; Hybridomas; Inflammation; Interleukin-2; Leukocytes; Lipoproteins, LDL; Lymphocytes; Male; Molsidomine; Rats; Rats, Inbred Strains; T-Lymphocytes | 1991 |
Inhibition of platelet activation by the nitrate Sin-1: studies with human aequorin-loaded platelets.
Topics: Aequorin; Humans; In Vitro Techniques; Molsidomine; Platelet Aggregation Inhibitors | 1990 |
Nitroglycerin-resistant coronary spasm treated with intracoronary linsidomine chlorhydrate (SIN-1).
Topics: Angiography; Coronary Vasospasm; Coronary Vessels; Humans; Injections, Intravenous; Male; Middle Aged; Molsidomine; Nitroglycerin; Vasodilator Agents | 1990 |
Reproducible uniform coronary vasomotor tone with nitrocompounds: prerequisite of quantitative coronary angiographic trials.
Topics: Angiography; Coronary Angiography; Coronary Disease; Female; Humans; Image Interpretation, Computer-Assisted; Isosorbide Dinitrate; Male; Middle Aged; Molsidomine; Nitro Compounds; Nitroglycerin; Radiographic Image Interpretation, Computer-Assisted; Reproducibility of Results; Vasodilation; Vasodilator Agents | 1990 |
Comparison of the cardioprotective effect of nitroglycerin, molsidomine and SIN-1 in rats with cardiac hypoxia.
Topics: Animals; Antihypertensive Agents; Heart Diseases; Hypoxia; Molsidomine; Nitroglycerin; Rats | 1990 |
Effect of nitroglycerin and a nitroglycerin-like substance in isoprenaline (ISO) necrosis and hypoxia.
Topics: Animals; Hypoxia; Isoproterenol; Molsidomine; Necrosis; Nitroglycerin; Rats | 1990 |
Effect of molsidomine on ex vivo platelet aggregation and plasma guanosine 3':5'-cyclic monophosphate levels in healthy volunteers.
Topics: Adult; Cyclic GMP; Female; Humans; Male; Molsidomine; Platelet Aggregation; Platelet Aggregation Inhibitors; Prodrugs; Vasodilator Agents | 1990 |
Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP.
Topics: Adenosine; Adenylyl Cyclases; Alprostadil; Animals; Blood Platelets; Cyclic AMP; Cyclic GMP; Enzyme Activation; Ferricyanides; Hemoglobins; In Vitro Techniques; Kinetics; Molsidomine; Nitroprusside; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinolones; Rabbits; Radioimmunoassay; Vasodilator Agents | 1990 |
Determination of the active metabolite of molsidomine in human plasma by reversed-phase high-performance liquid chromatography.
Topics: Antihypertensive Agents; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Humans; Middle Aged; Molsidomine | 1990 |
Persistence of the response to SIN1 on isolated coronary arteries rendered tolerant to nitroglycerin in vitro or in vivo.
Topics: Adolescent; Adult; Animals; Antihypertensive Agents; Coronary Vessels; Dogs; Drug Tolerance; Humans; In Vitro Techniques; Middle Aged; Molsidomine; Muscle, Smooth, Vascular; Nitroglycerin | 1988 |
Inhibition of calcium influx in thrombin-stimulated platelets by SIN-1, an activator of soluble guanylate cyclase.
Topics: Biological Transport; Blood Platelets; Calcium; Cyclic GMP; Enzyme Activation; Fluorescence; Guanylate Cyclase; Humans; In Vitro Techniques; Molsidomine; Solubility; Thrombin; Vasodilator Agents | 1989 |
Inhibition of platelet activating factor-induced platelet aggregation by molsidomine, SIN-1, and nitrates in vitro and ex vivo.
Topics: Cyclic GMP; Enzyme Activation; In Vitro Techniques; Molsidomine; Nitrates; Nitric Oxide; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Vasodilator Agents | 1989 |
Interaction between SIN-1 and prostacyclin in inhibiting platelet aggregation.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; In Vitro Techniques; Molsidomine; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Vasodilator Agents | 1989 |
Molsidomine is a donor of EDRF.
Topics: Cyclic GMP; Drug Tolerance; Endothelium, Vascular; Enzyme Activation; Humans; Molsidomine; Nitric Oxide; Platelet Activation; Vasodilator Agents | 1989 |
Anti-ischemic actions of molsidomine by venous and large coronary dilatation in combination with antiplatelet effects.
Topics: Animals; Blood Platelets; Coronary Vessels; Cyclic GMP; Dogs; Dose-Response Relationship, Drug; Hemodynamics; Molsidomine; Platelet Aggregation Inhibitors; Vasodilator Agents | 1989 |
Generation of NO from molsidomine (SIN-1) in vitro and its relationship to changes in coronary vessel tone.
Topics: Animals; Cells, Cultured; Coronary Circulation; Coronary Vessels; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Iloprost; Molsidomine; Nitric Oxide; Nitroglycerin; Oxyhemoglobins; Rabbits; Vasodilator Agents | 1989 |
Atherosclerosis and responses of human isolated coronary arteries to endothelium-dependent and -independent vasodilators.
Topics: Animals; Colforsin; Coronary Artery Disease; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Isoproterenol; Molsidomine; Nitroglycerin; Rodentia; Vasodilator Agents | 1989 |
Tolerance and cross-tolerance between SIN-1 and nitric oxide in bovine coronary arteries.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; Enzyme Activation; In Vitro Techniques; Molsidomine; Nitric Oxide; Nitroglycerin; Nitroprusside; Vasodilator Agents | 1989 |
Endothelium-dependent vasodilatation in human epicardial coronary arteries: effect of prolonged exposure to glyceryl trinitrate or SIN-1.
Topics: Adult; Analysis of Variance; Bradykinin; Calcimycin; Dinoprost; Drug Tolerance; Humans; In Vitro Techniques; Middle Aged; Molsidomine; Myocardial Contraction; Nitroglycerin; Substance P; Vasodilator Agents | 1989 |
Relaxations to endothelium-derived relaxing factor and the metabolite of molsidomine, SIN-1, in the aorta and the hindquarters of the rat.
Topics: Animals; Aorta; Aorta, Thoracic; Dose-Response Relationship, Drug; Drug Tolerance; Endothelium, Vascular; Hindlimb; Hypertension, Renal; Hypertension, Renovascular; In Vitro Techniques; Male; Molsidomine; Nitric Oxide; Nitroglycerin; Rats; Rats, Inbred Strains; Vascular Resistance | 1989 |
Oxygen and oxidation promote the release of nitric oxide from sydnonimines.
Topics: Biological Assay; Drug Stability; Hydrogen-Ion Concentration; Molsidomine; Nitric Oxide; Nitrosamines; Oxidation-Reduction; Pulmonary Artery; Vasodilator Agents | 1989 |
Effects of SIN-1 on electrical responses of the smooth muscle of the canine saphenous vein.
Topics: Analysis of Variance; Animals; Dinoprost; Dogs; Endothelins; Female; In Vitro Techniques; Male; Membrane Potentials; Methylene Blue; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Norepinephrine; Saphenous Vein; Sympathetic Nervous System; Synaptic Transmission; Vasodilator Agents | 1989 |
Relaxations to SIN-1, nitric oxide, and sodium nitroprusside in canine arteries and veins.
Topics: Analysis of Variance; Animals; Dinoprost; Dogs; Endothelins; Endothelium, Vascular; Femoral Artery; Femoral Vein; In Vitro Techniques; Molsidomine; Muscle Relaxation; Nitric Oxide; Nitroprusside; Norepinephrine; Vasodilator Agents | 1989 |
Effects of SIN-1 on isolated canine basilar arteries.
Topics: Animals; Basilar Artery; Cyclic GMP; Dogs; In Vitro Techniques; Molsidomine; Muscle Relaxation; Nitric Oxide; Nitroprusside; Vasodilator Agents | 1989 |
Interaction between endothelium-derived nitric oxide and SIN-1 in human and porcine blood vessels.
Topics: Analysis of Variance; Animals; Coronary Vessels; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Mammary Arteries; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Rodentia; Saphenous Vein; Vasodilator Agents | 1989 |
Modulation of the vasodilator action of SIN-1 by the endothelium.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Isoproterenol; Molsidomine; Nitric Oxide; Rabbits; Vasodilation; Vasodilator Agents | 1989 |
Mechanism underlying the inhibitory interaction between the nitrovasodilator SIN-1 and the endothelium.
Topics: Analysis of Variance; Animals; Coronary Vessels; Dogs; Female; Free Radicals; In Vitro Techniques; Male; Molsidomine; Nitric Oxide; Vasodilator Agents | 1989 |
SIN-1 stimulates the production of cyclic GMP but not cyclic AMP in porcine aortic endothelial cells.
Topics: Animals; Aorta, Thoracic; Cells, Cultured; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Heme; Methylene Blue; Molsidomine; Rodentia; Vasodilator Agents | 1989 |
Differential effect of SIN-1 on thromboxane and prostacyclin formation in platelets and endothelial cells.
Topics: Arachidonic Acids; Blood Platelets; Cells, Cultured; Endothelium, Vascular; Epoprostenol; Humans; Molsidomine; Oxygen Consumption; Thromboxanes; Umbilical Veins; Vasodilator Agents | 1989 |
Effects of SIN-1 on peripheral hemodynamics and viscoelastic properties of aorta in anesthetized rabbits.
Topics: Animals; Aorta, Abdominal; Blood Pressure; Elasticity; Energy Metabolism; Female; Hemodynamics; Hindlimb; Infusions, Intravenous; Male; Molsidomine; Muscle, Smooth, Vascular; Rabbits; Regional Blood Flow; Vascular Resistance; Vasodilator Agents | 1989 |
Coronary vasodilation with nitrocompounds--is there a maximum?
Topics: Administration, Sublingual; Adult; Aged; Coronary Circulation; Coronary Disease; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Molsidomine; Nitroglycerin; Pulmonary Wedge Pressure; Vasodilation; Vasodilator Agents | 1989 |
Effect of molsidomine and its metabolites on polymorphonuclear cell function and arachidonic acid metabolism.
Topics: Arachidonic Acid; Arachidonic Acids; Cyclic GMP; Glucuronidase; Humans; In Vitro Techniques; Molsidomine; Neutrophils; Nitrosamines; Vasodilator Agents | 1989 |
Nitroglycerin-induced tolerance affects multiple sites in the organic nitrate bioconversion cascade.
Topics: Animals; Cattle; Dose-Response Relationship, Drug; Drug Tolerance; Endothelium, Vascular; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Nitric Oxide; Nitroglycerin; Nitroprusside; Parasympatholytics; Vasodilator Agents | 1989 |
Tolerance to nitroglycerin is caused by reduced guanylate cyclase activation.
Topics: Animals; Cattle; Coronary Vessels; Cysteine; Drug Tolerance; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Kinetics; Molsidomine; Nitroglycerin; Vasodilator Agents | 1989 |
Clinical tolerance to nitroglycerin is due to impaired biotransformation of nitroglycerin and biological counterregulation, not to desensitization of guanylate cyclase.
Topics: Animals; Aorta; Cattle; Cells, Cultured; Cyclic GMP; Drug Tolerance; Endothelium, Vascular; Guanylate Cyclase; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Nitroprusside; Prodrugs; Rabbits; Vascular Resistance; Vasodilator Agents | 1989 |
Effect of a stimulant of guanylate cyclase, sin 1, on calcium movements and phospholipase C activation in thrombin-stimulated human platelets.
Topics: Blood Platelets; Calcium; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Humans; In Vitro Techniques; Molsidomine; Phosphatidic Acids; Serotonin; Thrombin; Type C Phospholipases | 1988 |
Stimulation of soluble coronary arterial guanylate cyclase by SIN-1.
Topics: Animals; Cations, Divalent; Cattle; Coronary Vessels; Cyclic GMP; Ferricyanides; Guanylate Cyclase; In Vitro Techniques; Methylene Blue; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Nitroprusside; Oxadiazoles; Sodium Nitrite; Sulfhydryl Compounds; Sydnones | 1986 |
Mode of action of nitrates with regard to vasodilatation and tolerance.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Nitrates; Nitroglycerin; Vasodilation | 1986 |
[Comparison of the effects of SIN-1, sodium nitroprusside and nitrate derivatives on the inhibition of blood platelet aggregation and activation of soluble platelet guanylate-cyclase].
Topics: Blood Platelets; Ferricyanides; Guanylate Cyclase; Humans; Molsidomine; Nitrates; Nitroprusside; Platelet Aggregation | 1987 |
[SIN-1 interactions with the generation of cyclic nucleotides and arachidonate oxide metabolites in the uterine muscle].
Topics: Animals; Arachidonic Acids; Cyclic AMP; Cyclic GMP; Epoprostenol; Female; Guanylate Cyclase; Guinea Pigs; Molsidomine; Myometrium | 1987 |
Direct comparison of the effects of nitroprusside, SIN 1, and various nitrates on platelet aggregation and soluble guanylate cyclase activity.
Topics: Adult; Blood Platelets; Enzyme Activation; Guanylate Cyclase; Humans; In Vitro Techniques; Molsidomine; Nitrates; Nitroprusside; Platelet Aggregation; Solubility | 1988 |
[Influence of antianginal drugs on Lypressin induced T-wave enhancement in the electrocardiogram of the rat].
Topics: Administration, Oral; Angina Pectoris; Animals; Coronary Vasospasm; Electrocardiography; Hypoxia; Isosorbide Dinitrate; Lypressin; Male; Molsidomine; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Rats; Rats, Inbred Strains; Verapamil | 1986 |
[Anti-ischemic effects of SIN-1, a molsidomine metabolite, during coronary angioplasty and antiplatelet effects in humans].
Topics: Adenosine Triphosphate; Administration, Oral; Angioplasty, Balloon; Coronary Disease; Coronary Vessels; Humans; Injections, Intra-Arterial; Molsidomine; Platelet Aggregation Inhibitors | 1988 |
[The family of sydnonimines (Corvasal, intracoronary Corvasal 1 mg). Analogies with EDRF (endothelium-derived relaxing factor)].
Topics: Biological Products; Coronary Vessels; Injections, Intra-Arterial; Molsidomine; Nitric Oxide; Platelet Aggregation Inhibitors; Vasodilator Agents | 1988 |
Mechanism of vasodilation by molsidomine.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; In Vitro Techniques; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Oxadiazoles; Sydnones; Vasodilator Agents | 1985 |
Cyclic GMP as the mediator of molsidomine-induced vasodilatation.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Endothelium; In Vitro Techniques; Methylene Blue; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Oxadiazoles; Phosphodiesterase Inhibitors; Sydnones; Time Factors; Vasodilation | 1986 |
[Effect of SIN-1 on the synthesis of leukotrienes in human polymorphonuclear cells].
Topics: Arachidonic Acids; Humans; Leukotriene A4; Leukotriene B4; Molsidomine; Neutrophils | 1987 |
[Mechanism of the vasodilating effect and blood platelet- antiaggregating activity of molsidomine and SIN-1].
Topics: Animals; Cyclic GMP; Molsidomine; Muscle, Smooth, Vascular; Nitrates; Platelet Aggregation; Vasodilation | 1987 |
Effects of nitrates in various vascular sections and regions.
Topics: Animals; Arteries; Arterioles; Blood Vessels; Dogs; Drug Tolerance; Hemodynamics; Molsidomine; Nitrates; Nitroglycerin; Vasodilation; Veins | 1986 |
[Release of plasminogen activator by SIN-1].
Topics: Animals; Molsidomine; Swine; Tissue Plasminogen Activator | 1987 |
[Biological effects of SIN-1 in the vascular wall].
Topics: Animals; Endothelium; Epoprostenol; Molsidomine; Muscle Contraction; Muscle, Smooth, Vascular; Nitroglycerin; Swine | 1987 |
[Influence of molsidomine, SIN-1 and nitroglycerin on the metabolism of prostaglandins by human fibroblasts].
Topics: Bradykinin; Fibroblasts; Humans; Molsidomine; Nitroglycerin; Prostaglandins | 1987 |
Modulation of prostacyclin/thromboxane formation by molsidomine during platelet-endothelial cell interactions.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cell Communication; Cells, Cultured; Endothelium, Vascular; Epoprostenol; Humans; Molsidomine; Thromboxanes | 1988 |
Mitochondrial sulfhydryl groups under oligomycin-inhibited, aging, and uncoupling conditions: beneficial influence of cardioprotective drugs.
Topics: Aging; Animals; In Vitro Techniques; Isosorbide Dinitrate; Mitochondria, Heart; Molsidomine; Oligomycins; Rats; Sulfhydryl Compounds; Tiopronin; Uncoupling Agents | 1988 |
Mechanism of action of antianginal drugs: what is it?
Topics: Angina Pectoris; Coronary Vessels; Humans; Injections, Intra-Arterial; Molsidomine | 1987 |
[Effects of SIN-1 on the early phases of blood platelet activation].
Topics: Blood Platelets; Humans; Molsidomine; Platelet Aggregation; Serotonin; Thromboxanes | 1987 |
[Effects of SIN-1 on the activation of phospholipase C and calcium mobilization induced by thrombin in blood platelets].
Topics: Blood Platelets; Calcium; Enzyme Activation; Humans; Molsidomine; Thrombin; Type C Phospholipases | 1987 |
[Effects of SIN-1, a metabolite of molsidomine, on paf-acether-blood platelets interactions].
Topics: Animals; Blood Platelets; Molsidomine; Platelet Activating Factor; Platelet Aggregation; Rabbits; Thromboxane A2 | 1987 |
[Effects of SIN-1 on the oxygenated metabolism of arachidonic acid in blood platelets and endothelial cells].
Topics: Arachidonic Acids; Blood Platelets; Endothelium; Humans; Molsidomine; Oxidation-Reduction | 1987 |
[Inhibition of the formation of platelet thrombus by molsidomine and SIN-1 in the mesenteric vessels rats].
Topics: Animals; Arterioles; Male; Mesenteric Vascular Occlusion; Molsidomine; Rats; Thrombosis; Venules | 1987 |
[Antithrombotic properties of the active metabolite of molsidomine, SIN-1].
Topics: Animals; Delayed-Action Preparations; Fibrinolysis; Humans; Molsidomine; Rabbits; Thrombosis | 1987 |
[Effects of SIN-1 on the metabolism of arachidonic acid in vascular smooth muscle cells in culture].
Topics: Animals; Arachidonic Acids; Cells, Cultured; Molsidomine; Muscle, Smooth, Vascular; Prostaglandins F | 1987 |
[Effects of sydnonimines derivatives on the antithrombogenic activity of endothelial cells in culture].
Topics: Cells, Cultured; Endothelium; Fibrinolysis; Molsidomine | 1987 |
Long-acting coronary vasodilatory action of the molsidomine metabolite Sin 1: a quantitative angiographic study.
Topics: Coronary Angiography; Coronary Disease; Coronary Vessels; Humans; Injections, Intra-Arterial; Molsidomine; Time Factors; Vasodilator Agents | 1987 |
Release of plasminogen activator by molsidomine and its active metabolite SIN-1.
Topics: Animals; Antihypertensive Agents; In Vitro Techniques; Molsidomine; Plasminogen Activators; Swine | 1987 |
Liver function and pharmacokinetics of molsidomine and its metabolite 3-morpholinosydnonimine in healthy volunteers.
Topics: Adult; Antipyrine; Humans; Indocyanine Green; Infusions, Intravenous; Kinetics; Liver; Liver Function Tests; Models, Biological; Molsidomine | 1986 |
Effect of molsidomine on cardiac preload, coronary artery diameter, and coronary resistance.
Topics: Animals; Blood Volume; Coronary Vessels; Dogs; Molsidomine; Oxadiazoles; Stroke Volume; Sydnones; Vascular Resistance; Vasodilator Agents | 1985 |
Pharmacokinetics of molsidomine in humans.
Topics: Animals; Biological Availability; Coronary Disease; Dogs; Half-Life; Humans; Kinetics; Molsidomine; Oxadiazoles; Sydnones; Vasodilator Agents | 1985 |
Relationship between pharmacokinetics and pharmacodynamics of molsidomine and its metabolites in humans.
Topics: Adult; Female; Half-Life; Hemodynamics; Humans; Kinetics; Male; Molsidomine; Oxadiazoles; Plethysmography, Impedance; Sydnones; Vasodilator Agents | 1985 |
The new long-acting coronary artery dilator molsidomine and its metabolite SIN-1.
Topics: Coronary Angiography; Coronary Vasospasm; Coronary Vessels; Female; Humans; Male; Middle Aged; Molsidomine; Oxadiazoles; Sydnones; Vasodilator Agents | 1985 |
Comparison of the influence of nitrates, molsidomine and SIN-1, a molsidomine metabolite in acute coronary insufficiency.
Topics: Coronary Circulation; Coronary Vasospasm; Coronary Vessels; Ergonovine; Humans; Molsidomine; Myocardial Infarction; Nitrates; Platelet Aggregation | 1985 |
The influence of molsidomine and its active metabolite SIN-1 on fibrinolysis and platelet aggregation.
Topics: Adenosine Diphosphate; Animals; Aspirin; Cats; Epoprostenol; Female; Fibrinolysis; Humans; In Vitro Techniques; Male; Molsidomine; Oxadiazoles; Platelet Aggregation; Rabbits; Sydnones | 1985 |
Stimulation of human platelet guanylate cyclase by nitroso compounds.
Topics: Blood Platelets; Dithiothreitol; Guanylate Cyclase; Humans; Molsidomine; Nitric Oxide; Nitroprusside; Nitrosamines; Nitroso Compounds; Platelet Aggregation; Sydnones | 1982 |
The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels.
Topics: Animals; Coronary Vessels; Cyclic AMP; Cyclic GMP; Dogs; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Molsidomine; Muscle Contraction; Muscle, Smooth, Vascular; Nitroglycerin; Oxadiazoles; Sydnones; Vasodilator Agents | 1983 |
Effect of molsidomine, an anti-anginal drug, on arachidonic acid metabolism in human platelets.
Topics: Antihypertensive Agents; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Humans; Molsidomine; Oxadiazoles; Phospholipids; Sydnones; Thromboxane B2 | 1984 |
SIN-1, the main metabolite of molsidomine, inhibits prostaglandin endoperoxide analogue- and arachidonic acid-induced platelet aggregation as well as platelet thromboxane A2 formation.
Topics: Animals; Arachidonic Acids; Blood Platelets; Drug Interactions; Female; Humans; Indoles; Male; Molsidomine; Oxadiazoles; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Pyridines; Rabbits; Sydnones; Thromboxane A2; Thromboxanes | 1982 |
Inhibitory effect of nitric oxide on the replication of a murine retrovirus in vitro and in vivo.
Topics: Animals; Antiviral Agents; Arginine; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Friend murine leukemia virus; Kinetics; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred DBA; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Sodium Nitrite; Virus Replication | 1995 |
Effect of nitric oxide donors on neointima formation and vascular reactivity in the collared carotid artery of rabbits.
Topics: Acetylcholine; Animals; Blood Pressure; Carotid Arteries; Cell Division; Dipeptides; In Vitro Techniques; Male; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Proliferating Cell Nuclear Antigen; Rabbits; Serotonin; Vasoconstriction | 1995 |
A cellular mechanism for nitric oxide-mediated cholinergic control of mammalian heart rate.
Topics: 1-Methyl-3-isobutylxanthine; Aminoquinolines; Animals; Arginine; Carbachol; Cardiotonic Agents; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Enzyme Inhibitors; GTP-Binding Proteins; Guanylate Cyclase; Heart Rate; Isoproterenol; Methylene Blue; Molsidomine; Muscarinic Agonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Platelet Aggregation Inhibitors; Rabbits; Receptors, Cholinergic; Receptors, Muscarinic; Sinoatrial Node; Thionucleotides | 1995 |
Intracoronary linsidomine abolishes acetylcholine-induced vasoconstriction of epicardial coronary arteries.
Topics: Acetylcholine; Coronary Circulation; Coronary Disease; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Hemodynamics; Humans; Male; Middle Aged; Molsidomine; Vasoconstriction; Vasodilation; Vasodilator Agents | 1993 |
Prostacyclin contributes to nitroglycerin-mediated relaxation of human umbilical arteries.
Topics: Epoprostenol; Female; Humans; In Vitro Techniques; Indomethacin; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Pregnancy; Umbilical Arteries; Vasodilation; Vasodilator Agents | 1993 |
Biosynthesis of nitric oxide activates iron regulatory factor in macrophages.
Topics: Aconitate Hydratase; Adenocarcinoma; Amino Acid Oxidoreductases; Animals; Arginine; Cell Line; Cells, Cultured; Enzyme Induction; Interferon-gamma; Iron-Regulatory Proteins; Kinetics; Leukemia L1210; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mitochondria; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Recombinant Proteins; RNA-Binding Proteins; Tumor Cells, Cultured | 1993 |
The sydnonimine C87-3754 evokes endothelium-independent relaxations and prevents endothelium-dependent contractions in blood vessels of the dog.
Topics: Animals; Dinoprost; Dogs; Drug Interactions; Electrophysiology; Endothelium, Vascular; Female; Male; Membrane Potentials; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Sydnones; Vasodilator Agents | 1993 |
Nitric oxide, superoxide and peroxynitrite: putative mediators of NMDA-induced cell death in cerebellar granule cells.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Catalase; Cell Death; Cells, Cultured; Cerebellum; Cyclic GMP; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Mice; Molsidomine; N-Methylaspartate; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Receptors, N-Methyl-D-Aspartate; Superoxide Dismutase; Superoxides; Xanthine Oxidase | 1993 |
Loss of endothelium-dependent relaxation in proximal pulmonary arteries from rats exposed to chronic hypoxia: effects of in vivo and in vitro supplementation with L-arginine.
Topics: Acetylcholine; Animals; Arginine; Calcimycin; Endothelins; Endothelium, Vascular; Hypoxia; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Phenylephrine; Pulmonary Artery; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 1993 |
Involvement of nitric oxide in the regulation of gonadotropin-releasing hormone release from the GT1-1 neuronal cell line.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cell Line; Cyclic GMP; Gonadotropin-Releasing Hormone; Mice; Mice, Transgenic; Molsidomine; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Norepinephrine; Sodium Nitrite | 1994 |
Endothelial and vascular smooth muscle responses are altered after left lung autotransplantation.
Topics: Acetylcholine; Amino Acid Oxidoreductases; Animals; Arginine; Bradykinin; Calcimycin; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Lung Transplantation; Male; Molsidomine; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phenylephrine; Pulmonary Artery; Pulmonary Circulation; Transplantation, Autologous; Vasoconstriction; Vasodilation; Vasodilator Agents | 1994 |
Evidence for an inhibitory effect of nitric oxides on neuropeptide secretion from isolated neural lobe of the rat pituitary gland.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Arginine Vasopressin; Hemoglobins; In Vitro Techniques; Male; Molsidomine; Neuropeptides; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxytocin; Pituitary Gland, Posterior; Rats; Rats, Wistar | 1994 |
SIN-1 reverses attenuation of hypercapnic cerebrovasodilation by nitric oxide synthase inhibitors.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cerebrovascular Circulation; Cyclic GMP; Hypercapnia; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Papaverine; Rats; Rats, Sprague-Dawley; Vasodilation | 1994 |
Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS.
Topics: Amino Acid Oxidoreductases; Animals; Astrocytes; Cell Death; Cells, Cultured; Drug Synergism; Enzyme Induction; In Vitro Techniques; Interferon-gamma; Interleukin-1; Kainic Acid; Mice; Molsidomine; N-Methylaspartate; Neurons; Nitric Oxide; Nitric Oxide Synthase; Penicillamine; S-Nitroso-N-Acetylpenicillamine | 1994 |
Nitric oxide inhibits bafilomycin-sensitive H(+)-ATPase activity in rat cortical collecting duct.
Topics: Amino Acid Oxidoreductases; Animals; Anti-Bacterial Agents; Arginine; Cyclic GMP; Enzyme Induction; Ethylmaleimide; Female; In Vitro Techniques; Interferon-gamma; Kidney Tubules, Collecting; Kinetics; Lipopolysaccharides; Macrolides; Macrophages; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Proton-Translocating ATPases; Rats; Rats, Sprague-Dawley; Vacuoles | 1994 |
Effect of potassium channel blockers on relaxations to a nitric oxide donor and to nonadrenergic nerve stimulation in guinea pig trachea.
Topics: Animals; Arginine; Charybdotoxin; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Nitric Oxide; Nitroarginine; Peptides; Potassium Channels; Scorpion Venoms; Trachea | 1994 |
Nitric oxide and cerebral ischemia.
Topics: Amino Acid Oxidoreductases; Analysis of Variance; Animals; Arginine; Cerebral Infarction; Dizocilpine Maleate; Ischemic Attack, Transient; Male; Mice; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Vasodilator Agents | 1994 |
The effect of hemorrhagic hypotension and retransfusion and 7-nitro-indazole on rCBF, NOS catalytic activity, and cortical NO content in the cat.
Topics: Acetylcholine; Adenosine Triphosphate; Amino Acid Oxidoreductases; Analgesics; Animals; Arginine; Blood Pressure; Blood Transfusion; Brain; Cats; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circulation; Electroencephalography; Hemorrhage; Hypotension; Indazoles; Male; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Norepinephrine; Organ Specificity; Parietal Lobe; Pituitary Gland; Regional Blood Flow; Spinal Cord; Vasodilator Agents | 1994 |
Nitric oxide donor SIN-1 inhibits mammalian cardiac calcium current through cGMP-dependent protein kinase.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Aminoquinolines; Animals; Calcium; Carbazoles; Cyclic GMP-Dependent Protein Kinases; Electric Conductivity; Guanylate Cyclase; Guinea Pigs; Heart; Indoles; Isoproterenol; Molsidomine; Myocardium; Nitric Oxide; Protein Kinase Inhibitors | 1995 |
Effects of a nitric oxide donor on glutamate and GABA release in striatum and hippocampus of the conscious rat.
Topics: Amino Acid Oxidoreductases; Animals; Antihypertensive Agents; Arginine; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Molsidomine; Neostriatum; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Wistar; Spectrometry, Fluorescence | 1994 |
Nitric oxide and cyclic guanosine 3',5'-monophosphate do not alter neuropeptide release from rat sensory neurons grown in culture.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Cyclic GMP; Molsidomine; Neurons, Afferent; Neuropeptides; Nitric Oxide; Nitroprusside; Rats; Rats, Sprague-Dawley; Substance P | 1994 |
Influence of nitric oxide synthase inhibition, nitric oxide and hydroperoxide on insulin release induced by various secretagogues.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Oxidoreductases; Animals; Arginine; Colforsin; Cyclic AMP; Cyclic GMP; Female; Glucose; Hydrogen Peroxide; Hydroxylamine; Hydroxylamines; In Vitro Techniques; Insulin; Islets of Langerhans; Mice; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peroxides; Reactive Oxygen Species; tert-Butylhydroperoxide; Vasodilator Agents | 1995 |
Modulation by nitric oxide of prostaglandin biosynthesis in the rat.
Topics: 6-Ketoprostaglandin F1 alpha; Amino Acid Oxidoreductases; Animals; Arachidonic Acid; Arginine; Capillary Permeability; Edema; Epoprostenol; Lipopolysaccharides; Male; Methylene Blue; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Wistar; Vasodilator Agents | 1995 |
Pyrrolidine dithiocarbamate selectively prevents the expression of the inducible nitric oxide synthase in the rat aorta.
Topics: Acetylcholine; Amino Acid Oxidoreductases; Analysis of Variance; Animals; Antioxidants; Aorta, Thoracic; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Induction; Interleukin-1; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; NADPH Dehydrogenase; Nitric Oxide Synthase; Pyrrolidines; Radioimmunoassay; Rats; Rats, Wistar; Thiocarbamates; Vasodilator Agents | 1994 |
The role of free radicals in NMDA-dependent neurotoxicity.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Calcium; Cells, Cultured; Cerebellar Cortex; Cyclic GMP; Electron Spin Resonance Spectroscopy; Enzyme Activation; Epilepsy; Feedback; Free Radicals; Glutamic Acid; Guanylate Cyclase; Kindling, Neurologic; Mice; Molsidomine; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Receptors, N-Methyl-D-Aspartate | 1994 |
Reciprocal modulation of aconitase activity and RNA-binding activity of iron regulatory factor by nitric oxide.
Topics: Aconitate Hydratase; Adenocarcinoma; Amino Acid Oxidoreductases; Animals; Arginine; Cell Line; Interferon-gamma; Iron-Regulatory Proteins; Leukemia P388; Lipopolysaccharides; Macrophages; Mice; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Recombinant Proteins; RNA-Binding Proteins; RNA, Messenger; Tumor Cells, Cultured; Vasodilator Agents | 1994 |
Secretion of cyclic GMP by cultured epithelial and fibroblast cell lines in response to nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cyclic AMP; Cyclic GMP; Epithelium; Fibroblasts; Guanylate Cyclase; Molsidomine; Nitric Oxide; Oxyhemoglobins; Probenecid; Swine | 1995 |
Rabbit penile corpus cavernosum: electrical and mechanical activity of isolated strips.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium Channels; Ion Channel Gating; Male; Molsidomine; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Penis; Rabbits; Stress, Mechanical; Tetraethylammonium; Tetraethylammonium Compounds | 1994 |
Streptokinase-prostacyclin--nitric oxide: in vivo interactions.
Topics: Animals; Arginine; Aspirin; Blood Pressure; Cats; Epoprostenol; Extracorporeal Circulation; Fibrinolysis; Heparitin Sulfate; Iloprost; Infusions, Intravenous; Injections, Intravenous; Molsidomine; Nitric Oxide; Nitroarginine; Platelet Aggregation; Streptokinase; Thrombosis; Vasodilator Agents | 1995 |
NG-nitro-L-arginine protects against hypoxia/hypoglycemia-induced decrease in CA1 presynaptic spikes in rat hippocampal slices.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Electrophysiology; Hippocampus; Hypoglycemia; Hypoxia, Brain; In Vitro Techniques; Male; Molsidomine; Nerve Fibers; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Penicillamine; Quinoxalines; Rats; Rats, Wistar; Receptors, Presynaptic; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents | 1995 |
Role of cyclic nucleotides and nitric oxide in blood mononuclear cell IgE production stimulated by IL-4.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Arginine; B-Lymphocytes; Cholera Toxin; Cyclic AMP; Cyclic GMP; Drug Synergism; Epinephrine; Gene Expression Regulation; Humans; Immunoglobulin E; Interleukin-4; Leukocytes, Mononuclear; Molsidomine; Nitric Oxide; omega-N-Methylarginine; Receptors, IgE; Recombinant Fusion Proteins | 1995 |
Synergistic phosphorylation of platelet rap1B by SIN-1 and iloprost.
Topics: Autoradiography; Blood Platelets; Blotting, Western; Cells, Cultured; Cyclic AMP; Cyclic GMP; Drug Synergism; GTP-Binding Proteins; Humans; Iloprost; Molsidomine; Nitric Oxide; Phosphorylation; Platelet Aggregation Inhibitors; rap GTP-Binding Proteins | 1995 |
Factors that contribute to spontaneous platelet aggregation and streptokinase-induced aggregation in whole blood.
Topics: Adenosine Diphosphate; Amino Acid Sequence; Hirudins; Humans; Iloprost; Magnesium Chloride; Molecular Sequence Data; Molsidomine; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Streptokinase; Thromboxane A2 | 1995 |
Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.
Topics: Base Sequence; Cell Adhesion Molecules; Cells, Cultured; Cytokines; Endothelium, Vascular; Glutathione; Humans; Molecular Sequence Data; Molsidomine; Monocytes; NF-kappa B; Nitric Oxide; Nitroprusside; Nitroso Compounds; RNA, Messenger; S-Nitrosoglutathione; Vascular Cell Adhesion Molecule-1 | 1995 |
Distribution of human i-NANC bronchodilator and nitric oxide-immunoreactive nerves.
Topics: Adolescent; Adult; Amino Acid Oxidoreductases; Arginine; Autonomic Nervous System; Bronchi; Bronchoconstriction; Child; Electrophysiology; Female; Humans; Male; Middle Aged; Molsidomine; Muscle, Smooth; Neural Inhibition; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Papaverine; Tetrodotoxin; Trachea; Vasodilator Agents | 1995 |
Antiatherosclerotic effects of oral naftidrofuryl in cholesterol-fed rabbits involve inhibition of neutrophil function.
Topics: Acetylcholine; Administration, Oral; Animals; Aorta, Abdominal; Aorta, Thoracic; Arteriosclerosis; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; Endothelium, Vascular; Fibrinogen; Luminescent Measurements; Luminol; Male; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nafronyl; Neutrophils; Nitric Oxide; Rabbits; Random Allocation; Substance P; Vasodilator Agents; Zymosan | 1995 |
Cyclic guanosine 3',5'-monophosphate mediates 3-morpholinosydnonimine-induced inhibition of human natural killer cells.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Cyclic GMP; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Humans; Interferon-gamma; Killer Cells, Natural; Methylene Blue; Molsidomine; Nitric Oxide; Tumor Cells, Cultured | 1995 |
Nitric oxide-mediated inactivation of mammalian ferrochelatase in vivo and in vitro: possible involvement of the iron-sulphur cluster of the enzyme.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cell Line; Cloning, Molecular; Enzyme Inhibitors; Escherichia coli; Ferrochelatase; Humans; Immunoblotting; Interferon-gamma; Iron-Sulfur Proteins; Lipopolysaccharides; Macrophages; Mammals; Mice; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Penicillamine; Recombinant Proteins; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents | 1995 |
Synergistic interaction of adenylate cyclase activators and nitric oxide donor SIN-1 on platelet cyclic AMP.
Topics: Adenylyl Cyclases; Alprostadil; Blood Platelets; Cyclic AMP; Cyclic GMP; Drug Synergism; Enzyme Activation; Guanylate Cyclase; Humans; Iloprost; In Vitro Techniques; Molsidomine; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors | 1995 |
Evidence for the role of nitric oxide in the circulation of the dental pulp.
Topics: Animals; Arginine; Blood Pressure; Cardiac Output; Cats; Cuspid; Dental Pulp; Enzyme Inhibitors; Heart Rate; Homeostasis; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxygen; Regional Blood Flow; Vascular Resistance; Vasodilator Agents | 1995 |
Nitric oxide hyperpolarizes rabbit mesenteric arteries via ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Biological Factors; Glyburide; In Vitro Techniques; Membrane Potentials; Mesenteric Arteries; Microelectrodes; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Patch-Clamp Techniques; Potassium Channels; Rabbits; Vasodilator Agents | 1995 |
Nitric oxide regulates IL-8 expression in melanoma cells at the transcriptional level.
Topics: Base Sequence; Binding Sites; CCAAT-Enhancer-Binding Proteins; Cell Line; DNA Primers; DNA-Binding Proteins; Gene Expression; Glutathione; Humans; Interleukin-8; Melanoma; Molecular Sequence Data; Molsidomine; Mutagenesis, Site-Directed; NF-kappa B; Nitric Oxide; Nitroso Compounds; Nuclear Proteins; Penicillamine; Platelet Aggregation Inhibitors; Polymerase Chain Reaction; Promoter Regions, Genetic; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Vasodilator Agents | 1995 |
[Effects of the nitric oxide donor SIN-1 on the membrane potential of mouse neuroblastoma-rat glioma hybrid cells].
Topics: Animals; Calcium; Depression, Chemical; Glioma; Hybrid Cells; Membrane Potentials; Mice; Molsidomine; Neuroblastoma; Nitric Oxide; Rats; Sodium; Tumor Cells, Cultured | 1995 |
The effect of redox-related species of nitrogen monoxide on transferrin and iron uptake and cellular proliferation of erythroleukemia (K562) cells.
Topics: Antioxidants; Biological Transport; Cell Division; Gene Expression Regulation, Leukemic; Humans; Iron; Iron-Regulatory Proteins; Leukemia, Erythroblastic, Acute; Macromolecular Substances; Models, Biological; Molsidomine; Neoplasm Proteins; Nitric Oxide; Nitroprusside; Oxidation-Reduction; Penicillamine; Protein Binding; Protein Processing, Post-Translational; Receptors, Transferrin; RNA Processing, Post-Transcriptional; RNA-Binding Proteins; RNA, Messenger; RNA, Neoplasm; S-Nitroso-N-Acetylpenicillamine; Sulfhydryl Compounds; Transferrin; Tumor Cells, Cultured; Up-Regulation | 1995 |
Nitric oxide donor prevents hepatic and systemic perfusion decrease induced by endotoxin in anesthetized rabbits.
Topics: Animals; Aorta; Blood Flow Velocity; Blood Pressure; Endotoxins; Liver; Male; Molsidomine; Nitric Oxide; Perfusion; Rabbits; Shock, Septic; Vasodilator Agents | 1995 |
Exogenous nitric oxide elicits chemotaxis of neutrophils in vitro.
Topics: Aminoquinolines; Cells, Cultured; Chemotactic Factors; Chemotaxis, Leukocyte; Cysteine; Enzyme Inhibitors; Guanylate Cyclase; Humans; Molsidomine; Neutrophils; Nitric Oxide; Penicillamine; S-Nitroso-N-Acetylpenicillamine; S-Nitrosothiols | 1995 |
Peroxynitrite-mediated inhibition of DOPA synthesis in PC12 cells.
Topics: Animals; Dihydroxyphenylalanine; Molsidomine; Nitrates; Oxidation-Reduction; PC12 Cells; Rats; Tyrosine | 1995 |
The effect of nitric oxide donors on the release of plasminogen activator inhibitor (PAI) from rabbit platelets in vitro.
Topics: Animals; Blood Platelets; Cells, Cultured; Molsidomine; Nitric Oxide; Plasminogen Inactivators; Rabbits; Triazoles | 1995 |
Cardiovascular actions of the furoxan CAS 1609, a novel nitric oxide donor.
Topics: Administration, Oral; Animals; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart Rate; Hemodynamics; Injections, Intravenous; Male; Microspheres; Molsidomine; Nitric Oxide; Oxadiazoles; Oxygen Consumption; Pulmonary Artery; Time Factors; Vasoconstriction; Vasodilation | 1995 |
Non-synergistic relaxant effects of vasoactive intestinal polypeptide and SIN-1 in human isolated cavernous artery and corpus cavernosum.
Topics: Arteries; Drug Interactions; Humans; In Vitro Techniques; Isometric Contraction; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Penis; Phenylephrine; Regional Blood Flow; Vasoactive Intestinal Peptide; Vasodilator Agents | 1995 |
Involvement of divalent ions in the nitric oxide-induced blockade of N-methyl-D-aspartate receptors in cerebellar granule cells.
Topics: Animals; Cations, Divalent; Cells, Cultured; Cerebellum; Glycine; Hydrogen-Ion Concentration; Membrane Potentials; Mice; Molsidomine; N-Methylaspartate; Neurons; Nitric Oxide; Oxidation-Reduction; Receptors, N-Methyl-D-Aspartate | 1995 |
Genetic and redox determinants of nitric oxide cytotoxicity in a Salmonella typhimurium model.
Topics: Base Sequence; DNA Primers; Genes, Bacterial; Glutathione; Microbial Sensitivity Tests; Molecular Sequence Data; Molsidomine; Mutagenesis; Nitrates; Nitric Oxide; Nitroso Compounds; Oxidation-Reduction; Polyamines; S-Nitrosoglutathione; Salmonella typhimurium; Species Specificity; Vasodilator Agents | 1995 |
The effect of NO-donors in bovine and rat pineal cells: stimulation of cGMP and cGMP-independent inhibition of melatonin synthesis.
Topics: Animals; Cattle; Cells, Cultured; Cyclic GMP; Isoproterenol; Melatonin; Molsidomine; Nitric Oxide; Nitroprusside; Pineal Gland; Rats; Stimulation, Chemical | 1995 |
Influence of chronic treatment with a nitric oxide donor on fatty streak development and reactivity of the rabbit aorta.
Topics: Acetylcholine; Animals; Aorta; Aortic Diseases; Arteriosclerosis; Body Weight; Cholesterol; Dietary Fats; Dose-Response Relationship, Drug; Molsidomine; Muscle Contraction; Nitric Oxide; Phenylephrine; Rabbits; Serotonin | 1995 |
Formation of F2-isoprostanes during oxidation of human low-density lipoprotein and plasma by peroxynitrite.
Topics: Antihypertensive Agents; Arachidonic Acid; Arteriosclerosis; Catalysis; Humans; In Vitro Techniques; Lipid Peroxidation; Lipoproteins, LDL; Molsidomine; Nitrates; Nitric Oxide; Oxidation-Reduction; Platelet Aggregation Inhibitors; Prostaglandins F, Synthetic; Superoxide Dismutase; Superoxides; Vasodilator Agents | 1995 |
Nitric oxide inhibition of human sperm motility.
Topics: Cyclic GMP; Hemoglobins; Humans; Male; Molsidomine; Nitric Oxide; Nitroprusside; Reactive Oxygen Species; Sperm Motility | 1995 |
Excess nitric oxide does not cause cellular, vascular, or mucosal dysfunction in the cat small intestine.
Topics: Animals; Blood Vessels; Capillary Permeability; Cats; Dose-Response Relationship, Drug; Edetic Acid; Intestinal Mucosa; Intestine, Small; Intestines; Molsidomine; Nitric Oxide; Permeability; Platelet Activating Factor; Sydnones | 1995 |
Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.
Topics: Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Cysteine; DNA; Free Radicals; Kinetics; Molsidomine; N-Methylaspartate; Necrosis; Neurons; Nitrates; Nitric Oxide; Oxidative Stress; Rats; S-Nitrosothiols; Superoxide Dismutase; Superoxides | 1995 |
Oxygen free radicals enhance the nitric oxide-induced covalent NAD(+)-linkage to neuronal glyceraldehyde-3-phosphate dehydrogenase.
Topics: Animals; Cells, Cultured; Corpus Striatum; Cysteine; Dithiothreitol; Free Radicals; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenases; Mice; Molsidomine; NAD; Neurons; Nitric Oxide; Nitroprusside; Oxidation-Reduction; Oxygen; Rats; Superoxides | 1995 |
Endothelial damage induced by nitric oxide: synergism with reactive oxygen species.
Topics: Analysis of Variance; Animals; Antimycin A; Catalase; Cells, Cultured; Endothelium; Kinetics; Liver; Molsidomine; Nitric Oxide; Nitroprusside; Penicillamine; Potassium Cyanide; Rats; Reactive Oxygen Species; Rotenone; S-Nitroso-N-Acetylpenicillamine; Time Factors; Vasodilator Agents | 1995 |
Dissimilarity between prostaglandin E1 and nitric oxide donors as potentiators of plasma exudation in the rabbit skin in vivo.
Topics: Alprostadil; Animals; Arginine; Bradykinin; Capillary Permeability; Edema; Exudates and Transudates; Histamine; Histamine Antagonists; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Nitroprusside; Rabbits; Skin; Vasodilator Agents | 1995 |
Evidence for the involvement of cGMP in neural bronchodilator responses in humal trachea.
Topics: Adenosine Monophosphate; Adolescent; Adult; Arginine; Bronchoconstriction; Child; Chymotrypsin; Cyclic GMP; Electric Conductivity; Epithelium; Female; Humans; Male; Methylene Blue; Middle Aged; Molsidomine; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Tetrodotoxin; Time Factors; Trachea; Vasoactive Intestinal Peptide; Vasodilator Agents | 1995 |
Inhibition and ADP-ribose pyrophosphatase-I by nitric-oxide-generating systems: a mechanism linking nitric oxide to processes dependent on free ADP-ribose.
Topics: Adenosine Diphosphate Ribose; Animals; Hydrogen-Ion Concentration; Kinetics; Molsidomine; Nitric Oxide; Nitroprusside; Pyrophosphatases; Rats; Sodium Nitrite; Vasodilator Agents | 1995 |
Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cattle; Deoxyguanosine; Deoxyribonucleotides; DNA; DNA Damage; Free Radical Scavengers; Humans; Molsidomine; Nitrates; Nitric Oxide; Oxidative Stress; Superoxides | 1995 |
Potentiation of the hyporeactivity induced by in vivo endothelial injury in the rat carotid artery by chronic treatment with fish oil.
Topics: Analysis of Variance; Animals; Arginine; Blood Pressure; Body Weight; Carotid Arteries; Carotid Artery Injuries; Catheterization; Cyclic GMP; Endothelium, Vascular; Fatty Acids; Fish Oils; Indomethacin; Isometric Contraction; Male; Methylene Blue; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Phenylephrine; Rats; Rats, Wistar; Superoxide Dismutase; Vascular Resistance; Vasodilator Agents | 1995 |
Increased cytotoxicity of 3-morpholinosydnonimine to HepG2 cells in the presence of superoxide dismutase. Role of hydrogen peroxide and iron.
Topics: Catalysis; Cell Survival; Drug Interactions; Humans; Hydrogen Peroxide; Hydroxyl Radical; Iron; Molsidomine; Spin Labels; Superoxide Dismutase; Tumor Cells, Cultured | 1995 |
Interleukin-1 beta effects on cyclic GMP and cyclic AMP in cultured rat islets of Langerhans-arginine-dependence and relationship to insulin secretion.
Topics: 1-Methyl-3-isobutylxanthine; Aminoquinolines; Animals; Antihypertensive Agents; Arginine; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Female; Insulin; Insulin Secretion; Interleukin-1; Islets of Langerhans; Kinetics; Molsidomine; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley | 1993 |
Interaction between hydralazine and nitrovasodilators in vascular smooth muscle.
Topics: Animals; Aorta, Thoracic; Drug Interactions; Drug Tolerance; Hydralazine; In Vitro Techniques; Isoniazid; Male; Molsidomine; Muscle Contraction; Muscle, Smooth, Vascular; Nitroglycerin; Rats; Rats, Wistar; Vasodilator Agents | 1993 |
Differential regulation of inducible nitric oxide synthase by fibroblast growth factors and transforming growth factor beta in bovine retinal pigmented epithelial cells: inverse correlation with cellular proliferation.
Topics: Amino Acid Oxidoreductases; Animals; Catechols; Cattle; Cells, Cultured; Enzyme Induction; Epidermal Growth Factor; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Heparin; Humans; Interferon-gamma; Kinetics; Lipopolysaccharides; Molsidomine; Nitric Oxide Synthase; Nitriles; Nitrites; Pigment Epithelium of Eye; Recombinant Proteins; Suramin; Transforming Growth Factor beta; Tyrphostins; Vasodilator Agents | 1993 |
Nitric oxide modulates the release of vasopressin from rat hypothalamic explants.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Arginine Vasopressin; Hypothalamus; Male; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Potassium Chloride; Rats; Rats, Wistar | 1993 |
Synergistic platelet antiaggregatory effects of the adenylate cyclase activator iloprost and the guanylate cyclase activating agent SIN-1 in vivo.
Topics: Adenylyl Cyclase Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Drug Synergism; Enzyme Activation; Guanylate Cyclase; Iloprost; Male; Molsidomine; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Signal Transduction | 1993 |
Nitric oxide donor-mediated killing of bioluminescent Escherichia coli.
Topics: Cloning, Molecular; Escherichia coli; Luciferases; Luminescent Measurements; Molsidomine; Nitric Oxide; Triazoles | 1994 |
Responses of the post-term arterial duct to oxygen, prostaglandin E2, and the nitric oxide donor, 3-morpholinosydnonimine, in lambs and their clinical implications.
Topics: Animals; Aorta; Dinoprostone; Ductus Arteriosus; In Vitro Techniques; Molsidomine; Oxygen; Sheep; Vasoconstriction; Vasodilator Agents | 1995 |
Exogenous and endogenous nitric oxide attenuates tumor necrosis factor synthesis in the murine macrophage cell line RAW 264.7.
Topics: Animals; Arginine; Cell Line; Dose-Response Relationship, Drug; In Vitro Techniques; Macrophages; Mice; Molsidomine; Nitric Oxide; Time Factors; Tumor Necrosis Factor-alpha | 1995 |
Relative potency and arteriovenous selectivity of nitrovasodilators on human blood vessels: an insight into the targeting of nitric oxide delivery.
Topics: Arteries; Female; Glutathione; Humans; Male; Molsidomine; Nitric Oxide; Nitroglycerin; Nitroprusside; Nitroso Compounds; S-Nitrosoglutathione; Saphenous Vein; Vasodilation; Vasodilator Agents; Veins | 1995 |
Activation of endothelial guanylate cyclase inhibits cellular reactivity.
Topics: Arachidonic Acid; Cell Adhesion; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Epoprostenol; Guanylate Cyclase; Humans; Molsidomine; Nitric Oxide; Nitroprusside; Oxadiazoles; Platelet Activating Factor; Thrombin; Umbilical Veins | 1995 |
Glyceryl trinitrate but not spontaneous NO donors preserve myocardial function and cell integrity in ischemic rabbit hearts.
Topics: Animals; Creatine Kinase; In Vitro Techniques; Molsidomine; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitroglycerin; Rabbits; Superoxide Dismutase | 1995 |
Effects of NO-donors, SIN-1 and GEA 3175 on prostacyclin and cGMP synthesis in cultured rat endothelial cells.
Topics: Animals; Arginine; Calcimycin; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Epoprostenol; Female; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Triazoles | 1995 |
Formation of F2-isoprostanes during the oxidation of human low density lipoprotein by peroxynitrite.
Topics: Arachidonic Acids; Dinoprost; Humans; Kinetics; Lipoproteins, LDL; Molsidomine; Nitrates; Oxidation-Reduction; Platelet Aggregation Inhibitors | 1995 |
The rationale for prostaglandin E1 (alpha-alprostadil) in the management of male impotence.
Topics: Alprostadil; Erectile Dysfunction; Humans; Impotence, Vasculogenic; Male; Molsidomine; Moxisylyte; Papaverine; Penile Induration; Phentolamine | 1995 |
Effect of modifying nitric oxide pathway on liver circulation in a rabbit endotoxin shock model.
Topics: Animals; Arginine; Blood Flow Velocity; Blood Pressure; Hepatic Artery; Liver Circulation; Male; Mesenteric Arteries; Molsidomine; Nitric Oxide; Nitroarginine; Portal Vein; Rabbits; Shock, Septic; Vasodilator Agents | 1994 |
Increased nitric oxide synthesis during the development of endotoxin tolerance.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Animals; Arachidonic Acids; Arginine; Cells, Cultured; Drug Tolerance; Endotoxins; Lethal Dose 50; Lipopolysaccharides; Macrophages, Peritoneal; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Rats; Reference Values; Salmonella enteritidis | 1995 |
K+ channel opening mediates hyperpolarizations by nitric oxide donors and IJPs in opossum esophagus.
Topics: Animals; Chlorides; Electric Conductivity; Electrophysiology; Esophagus; Female; Gap Junctions; Guanylate Cyclase; Male; Molsidomine; Muscle, Smooth; Nerve Block; Neural Inhibition; Nitric Oxide; Nitroprusside; Opossums; Potassium Channel Blockers; Potassium Channels; Vasodilator Agents | 1995 |
Nitrogen monoxide decreases iron uptake from transferrin but does not mobilise iron from prelabelled neoplastic cells.
Topics: Animals; Cell Line; Cyclic GMP; Humans; Iodine Radioisotopes; Iron; Iron Radioisotopes; Melanoma; Mice; Molsidomine; Nitric Oxide; Nitrites; Nitroprusside; Thymidine; Transferrin | 1995 |
Effects of Trolox C and SIN-1 on arachidonic acid metabolism and on cyclic GMP formation in leukocytes.
Topics: Antioxidants; Arachidonic Acid; Calcimycin; Centrifugation, Density Gradient; Chromans; Cyclic GMP; Dibutyryl Cyclic GMP; Dinoprostone; Dose-Response Relationship, Drug; Guanylate Cyclase; Humans; Leukotriene B4; Molsidomine; Neutrophils; Radioimmunoassay; Vasodilator Agents; Vitamin E | 1994 |
Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance.
Topics: Acetylcholine; Animals; Aorta; Biphenyl Compounds; Colforsin; Dose-Response Relationship, Drug; Drug Tolerance; Endothelium, Vascular; Female; In Vitro Techniques; Liposomes; Male; Molsidomine; Nitro Compounds; Nitroglycerin; Onium Compounds; Rabbits; Superoxide Dismutase; Superoxides; Vasodilation; Vasodilator Agents | 1995 |
Selective regulation of dendritic MAP2 mRNA levels in hippocampal granule cells by nitric oxide.
Topics: Animals; Base Sequence; Cyclic GMP; Cytoskeleton; Dendrites; Gene Expression Regulation; Hippocampus; Male; Microtubule-Associated Proteins; Molecular Sequence Data; Molsidomine; N-Methylaspartate; Nerve Tissue Proteins; Nitric Oxide; Nitroprusside; Rats; Rats, Wistar; Receptors, Glutamate; RNA, Messenger | 1994 |
Cultured endothelial cells restore vasodilator responses to coronary arteries with impaired endothelial function and alter the response to a nitric oxide donor.
Topics: Animals; Arginine; Blood Flow Velocity; Calcimycin; Cells, Cultured; Coronary Circulation; Coronary Disease; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide; Umbilical Veins; Vasodilator Agents | 1994 |
[Evaluation of coronary vasomotricity by intracoronary ultrasonography].
Topics: Aged; Cold Temperature; Coronary Vessels; Endothelium, Vascular; Female; Humans; Hypercholesterolemia; Male; Middle Aged; Molsidomine; Papaverine; Ultrasonography; Vasodilator Agents; Vasomotor System | 1994 |
Differential effects of nitrovasodilators and nitric oxide on porcine tracheal and bronchial muscle in vitro.
Topics: Animals; Bronchi; Bronchoconstriction; Female; Hemoglobins; In Vitro Techniques; Male; Methylene Blue; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitroprusside; Swine; Trachea; Vasodilator Agents | 1994 |
KCa channel antagonists reduce NO donor-mediated relaxation of vascular and tracheal smooth muscle.
Topics: Animals; Calcium; Cyclic GMP; Guinea Pigs; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Nitric Oxide; Penicillamine; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Trachea | 1995 |
The comparative toxicity of nitric oxide and peroxynitrite to Escherichia coli.
Topics: Escherichia coli; Free Radicals; Hydrogen Peroxide; Molsidomine; Nitrates; Nitric Oxide; Oxyhemoglobins; Toxicity Tests | 1995 |
Influence of SIN-1 and sodium nitroprusside (NANP) on ox-LDL metabolism in macrophages.
Topics: Animals; Arginine; Lipoproteins, LDL; Macrophages; Molsidomine; Nitric Oxide; Nitroarginine; Nitroprusside; Oxidation-Reduction; Rats; Rats, Wistar | 1994 |
Regulatory role of nitric oxide in the IL-4-induced IgE production by normal human peripheral blood mononuclear cells.
Topics: Arginine; Humans; Immunoglobulin E; In Vitro Techniques; Interleukin-4; Leukocytes, Mononuclear; Molsidomine; Nitric Oxide; Nitrites; omega-N-Methylarginine; Oxidants; Receptors, IgE | 1994 |
Nitric oxide regulates the calcium current in isolated human atrial myocytes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Anura; Calcium Channels; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Female; Heart; Heart Atria; Humans; Isoproterenol; Kinetics; Male; Membrane Potentials; Middle Aged; Milrinone; Molsidomine; Nitric Oxide; Patch-Clamp Techniques; Pyridones; Time Factors; Vasodilator Agents | 1995 |
Interaction between cGMP-dependent dilators and autoregulation in rat preglomerular vasculature.
Topics: Animals; Atrial Natriuretic Factor; Cyclic GMP; Dose-Response Relationship, Drug; Homeostasis; Kidney Glomerulus; Male; Molsidomine; Nitroprusside; Rats; Rats, Sprague-Dawley; Renal Circulation; Vasodilator Agents | 1995 |
cGMP mediates the desensitization to bradykinin in isolated canine coronary arteries.
Topics: Animals; Arginine; Arteries; Bradykinin; Coronary Vessels; Cyclic GMP; Dogs; Drug Resistance; In Vitro Techniques; Methylene Blue; Molsidomine; Nitroarginine; Oxyhemoglobins; Potassium; Vasodilation; Vasodilator Agents | 1995 |
Nitric oxide blocks bile canalicular contraction by inhibiting inositol trisphosphate-dependent calcium mobilization.
Topics: Animals; Bile Canaliculi; Calcium; Calcium Channel Blockers; Cyclic GMP; Inositol 1,4,5-Trisphosphate; Male; Molsidomine; Muscle Contraction; Nitric Oxide; Nitroprusside; Rats; Signal Transduction; Vasodilator Agents | 1995 |
Nitric oxide-releasing non-steroidal anti-inflammatory drugs: a novel approach for reducing gastrointestinal toxicity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Gastric Mucosa; Gastrointestinal Diseases; Male; Molsidomine; Nitric Oxide; Nitroprusside; Rats; Rats, Wistar | 1994 |
Failure of nitric oxide donors to alter arrhythmias induced by acute myocardial ischaemia or reperfusion in anaesthetized rats.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cyclic AMP; Cyclic GMP; Hemodynamics; Isosorbide Dinitrate; Male; Molsidomine; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitroprusside; Rats; Rats, Wistar; Vasodilator Agents | 1995 |
Sensitivity of the essential zinc-thiolate moiety of yeast alcohol dehydrogenase to hypochlorite and peroxynitrite.
Topics: Alcohol Dehydrogenase; Cysteine; Histidine; Hydrogen Peroxide; Hypochlorous Acid; Kinetics; Molsidomine; Nitrates; Sulfhydryl Compounds; Taurine; Zinc | 1995 |
Effects of cGMP on calcium handling in ATP-stimulated rat resistance arteries.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium-Transporting ATPases; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Male; Mesenteric Arteries; Molsidomine; Myosins; Nitrendipine; Nitroprusside; Phosphorylation; Rats; Rats, Wistar; Terpenes; Thapsigargin; Vascular Resistance; Vasoconstriction | 1995 |
Nitric oxide regulates cardiac Ca2+ current. Involvement of cGMP-inhibited and cGMP-stimulated phosphodiesterases through guanylyl cyclase activation.
Topics: Animals; Calcium Channels; Colforsin; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Heart Ventricles; In Vitro Techniques; Isoproterenol; Molsidomine; Nitric Oxide; Phosphoric Diester Hydrolases; Rana esculenta | 1993 |
Nitric oxide stimulates Ca(2+)-independent synaptic vesicle release.
Topics: Animals; Calcium; Fluorescent Dyes; Glutamates; Glutamic Acid; Hippocampus; Indoles; Kinetics; Male; Molsidomine; Nitric Oxide; Nitroprusside; Penicillamine; Potassium Chloride; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Sodium Nitrite; Spectrometry, Fluorescence; Synaptic Vesicles; Vasodilator Agents | 1994 |
Nitric oxide has no chronotropic effect in right atria isolated from rat heart.
Topics: Acetylcholine; Aminoquinolines; Animals; Aorta, Thoracic; Arginine; Cyclic GMP; Guanylate Cyclase; Heart Atria; Heart Rate; In Vitro Techniques; Male; Methylene Blue; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroarginine; Norepinephrine; Parasympathetic Nervous System; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Vasodilator Agents | 1994 |
Phosphorylation of focal adhesion vasodilator-stimulated phosphoprotein at Ser157 in intact human platelets correlates with fibrinogen receptor inhibition.
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Blood Proteins; Cell Adhesion Molecules; Colforsin; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; In Vitro Techniques; Kinetics; Membrane Proteins; Microfilament Proteins; Molsidomine; Nitroprusside; Phosphoproteins; Phosphoserine; Platelet Membrane Glycoproteins; Protein Kinases; Protein-Tyrosine Kinases; Serine; Vasodilator Agents | 1994 |
The effect of nitric oxide donors on insulin secretion, cyclic GMP and cyclic AMP in rat islets of Langerhans and the insulin-secreting cell lines HIT-T15 and RINm5F.
Topics: Animals; Cell Line; Cyclic AMP; Cyclic GMP; Drug Interactions; Female; Glutathione; Hydroxylamine; Hydroxylamines; Insulin; Insulin Secretion; Islets of Langerhans; Molsidomine; Nitric Oxide; Nitroso Compounds; Penicillamine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione | 1994 |
Concurrent generation of nitric oxide and superoxide damages surfactant protein A.
Topics: Humans; Molsidomine; Nitrates; Nitric Oxide; Oxidation-Reduction; Penicillamine; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Reactive Oxygen Species; Rhodamines; S-Nitroso-N-Acetylpenicillamine; Superoxides; Time Factors | 1994 |
NO donor SIN-1 protects against reoxygenation-induced cardiomyocyte injury by a dual action.
Topics: Adenosine Diphosphate; Animals; Antihypertensive Agents; Cell Hypoxia; Cells, Cultured; Dose-Response Relationship, Drug; Electric Stimulation; Heart; Heart Ventricles; Kinetics; Male; Methylene Blue; Molsidomine; Myocardial Contraction; Myocardium; Nitric Oxide; Nitroprusside; Oxygen; Rats; Rats, Wistar; Thermodynamics; Time Factors | 1994 |
Involvement of Fc epsilon RII/CD23 and L-arginine-dependent pathway in IgE-mediated stimulation of human monocyte functions.
Topics: Arginine; Cells, Cultured; Cytokines; Humans; Immunoglobulin E; Molsidomine; Monocytes; Nitric Oxide; omega-N-Methylarginine; Receptors, IgE; Signal Transduction; Superoxides; Thromboxane B2 | 1994 |
Potentiation of nonadrenergic noncholinergic relaxation of human isolated bronchus by selective inhibitors of phosphodiesterase isozymes.
Topics: Atropine; Bronchi; Colforsin; Electric Stimulation; Histamine; Humans; In Vitro Techniques; Indomethacin; Isoenzymes; Molsidomine; Muscle Relaxation; Nitroprusside; Phosphodiesterase Inhibitors; Propranolol; Purinones; Pyrrolidinones; Rolipram | 1994 |
Smooth muscle tone regulation in rabbit cavernosal and spongiosal tissue by cyclic AMP- and cyclic GMP-dependent mechanisms.
Topics: Animals; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Molsidomine; Muscle Tonus; Muscle, Smooth; Penis; Phenylephrine; Phosphodiesterase Inhibitors; Rabbits | 1994 |
[Effects of intravenous administration of nitroglycerin and SIN-1 or molsidomine on epicardial arterial diameter in patients with stable coronary heart disease].
Topics: Coronary Circulation; Coronary Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Drug Tolerance; Humans; Infusions, Intravenous; Molsidomine; Nitroglycerin; Vascular Resistance; Vasodilator Agents | 1994 |
Nitric oxide alters proenkephalin and prodynorphin gene expression in hippocampal granule cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Base Sequence; Cyclic GMP; Dendrites; Enkephalins; Gene Expression Regulation; Hippocampus; In Situ Hybridization; Molecular Sequence Data; Molsidomine; N-Methylaspartate; Nitric Oxide; Nitroprusside; Protein Precursors; Rats; RNA, Messenger; Vasodilator Agents | 1994 |
An ADP-ribosyltransferase as a potential target for nitric oxide action in hippocampal long-term potentiation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cyclic GMP; Dibutyryl Cyclic GMP; Evoked Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Molsidomine; N-Methylaspartate; NAD; Niacinamide; Nitric Oxide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
[Value of linsidomine (SIN 1) in the evaluation of myocardial viability by 201-Tl scintigraphy after exertion].
Topics: Adult; Aged; Aged, 80 and over; Exercise Test; Female; Heart; Humans; Injections, Intravenous; Male; Middle Aged; Molsidomine; Myocardial Ischemia; Radionuclide Imaging; Thallium Radioisotopes; Vasodilator Agents | 1994 |
Reduction of focal cerebral ischemic damage by delayed treatment with nitric oxide donors.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Electroencephalography; Male; Molsidomine; Nitric Oxide; Rats; Rats, Inbred SHR; Time Factors | 1994 |
Mechanism of covalent modification of glyceraldehyde-3-phosphate dehydrogenase at its active site thiol by nitric oxide, peroxynitrite and related nitrosating agents.
Topics: Adenosine Diphosphate Ribose; Binding Sites; Borates; Dithiothreitol; Glyceraldehyde-3-Phosphate Dehydrogenases; Molsidomine; Nitrates; Nitric Oxide; Oxidation-Reduction; Sulfhydryl Compounds; Superoxide Dismutase | 1994 |
Reaction of peroxynitrite with oxyhaemoglobin: interference with photometrical determination of nitric oxide.
Topics: Electrochemistry; Kinetics; Molsidomine; Nitrates; Nitric Oxide; Oxyhemoglobins; Photochemistry; Spectrophotometry; Superoxide Dismutase | 1994 |
Regulation of blood-brain barrier endothelial cells by nitric oxide.
Topics: Animals; Blood-Brain Barrier; Brain; Cell Membrane; Cells, Cultured; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Guanosine 5'-O-(3-Thiotriphosphate); Male; Models, Cardiovascular; Molsidomine; Nitric Oxide; Nitroprusside; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Tetraethylammonium Compounds; Vasodilator Agents | 1994 |
Altered nitric oxide production and exogenous nitric oxide do not affect the proliferation of rat mesangial cells.
Topics: Animals; Arginine; Cell Division; Cells, Cultured; Cyclic GMP; Glomerular Mesangium; Interleukin-1; Lipopolysaccharides; Molsidomine; Nitric Oxide; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley | 1994 |
Involvement of Fc epsilon RII/CD23 and L-arginine dependent pathway in IgE-mediated activation of human eosinophils.
Topics: Antibodies, Monoclonal; Antihypertensive Agents; Arginine; Bone Marrow Cells; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Eosinophils; Hematopoietic Stem Cells; Humans; Immunoglobulin E; Kinetics; Molsidomine; omega-N-Methylarginine; Peroxides; Receptors, IgE; Superoxides; Tumor Necrosis Factor-alpha | 1994 |
Effect of molsidomine and linsidomine on the human isolated bronchus and the guinea-pig isolated trachea.
Topics: Animals; Bronchi; Bronchodilator Agents; Epithelium; Guinea Pigs; Humans; In Vitro Techniques; Isoproterenol; Male; Methylene Blue; Molsidomine; Muscle, Smooth; Nitroprusside; Purinones; Pyridazines; Theophylline; Trachea | 1993 |
Nitric oxide donors increase blood flow and reduce brain damage in focal ischemia: evidence that nitric oxide is beneficial in the early stages of cerebral ischemia.
Topics: Animals; Arterial Occlusive Diseases; Brain; Brain Ischemia; Cerebral Arteries; Cerebral Infarction; Cerebrovascular Circulation; Molsidomine; Nitric Oxide; Nitroprusside; Papaverine; Platelet Aggregation; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley | 1994 |
Ischemic preconditioning protects against coronary endothelial dysfunction induced by ischemia and reperfusion.
Topics: Acetylcholine; Animals; Arginine; Calcimycin; Coronary Vessels; Endothelium, Vascular; Male; Molsidomine; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Serotonin; Vasodilator Agents | 1994 |
Termination of endothelin signaling: role of nitric oxide.
Topics: Animals; Antihypertensive Agents; Calcium; CHO Cells; Cricetinae; DNA; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vascular; Intercellular Signaling Peptides and Proteins; Microscopy, Electron; Molsidomine; Nitric Oxide; Nitroprusside; Peptides; Receptors, Endothelin; Signal Transduction; Transfection; Wasp Venoms | 1994 |
Effects of nicorandil on human isolated corpus cavernosum and cavernous artery.
Topics: Adult; Aged; Benzopyrans; Cromakalim; Humans; In Vitro Techniques; Male; Middle Aged; Molsidomine; Niacinamide; Nicorandil; Penis; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
SIN-1 partially and RGDS totally counteracts platelet aggregation as assessed in vitro by two independent whole blood methods.
Topics: Amino Acid Sequence; Electric Conductivity; Humans; Molecular Sequence Data; Molsidomine; Oligopeptides; Platelet Aggregation Inhibitors | 1993 |
Effects of nitric oxide donors in vitro on the arachidonic acid-induced platelet release reaction and platelet cyclic GMP concentration in pre-eclampsia.
Topics: Adolescent; Adult; Blood Platelets; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Female; Humans; Molsidomine; Nitric Oxide; Nitroprusside; Platelet Activation; Pre-Eclampsia; Pregnancy | 1994 |
An impurity present in some samples of SIN-1 oxidizes it to nitric oxide in anaerobic solutions.
Topics: Anaerobiosis; Animals; Drug Contamination; Electron Spin Resonance Spectroscopy; Hemoglobins; Humans; Molsidomine; Nitric Oxide; Oxygen; Rabbits; Solutions | 1994 |
Spin-trapping studies of peroxynitrite decomposition and of 3-morpholinosydnonimine N-ethylcarbamide autooxidation: direct evidence for metal-independent formation of free radical intermediates.
Topics: Benzoates; Cyclic N-Oxides; Deoxyribose; Electron Spin Resonance Spectroscopy; Free Radicals; Glutathione; Hydroxyl Radical; Models, Chemical; Molsidomine; Nitrates; Oxidation-Reduction | 1994 |
Nitric oxide decreases in vitro phagocytosis of photoreceptor outer segments by bovine retinal pigmented epithelial cells.
Topics: Animals; Cattle; Cells, Cultured; Cyclic GMP; Interferon-gamma; Lipopolysaccharides; Molsidomine; Nitric Oxide; Phagocytosis; Pigment Epithelium of Eye; Rod Cell Outer Segment | 1994 |
Stimulatory and inhibitory action of nitric oxide donor agents vs. nitrovasodilators on reactive oxygen production by isolated polymorphonuclear leukocytes.
Topics: Animals; Arginine; Dogs; Free Radical Scavengers; Luminescent Measurements; Luminol; Molsidomine; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Reactive Oxygen Species; Vasodilator Agents | 1994 |
Inhibition of hepatic gluconeogenesis by nitric oxide: a comparison with endotoxic shock.
Topics: Animals; Dihydroxyacetone; Endotoxins; Fructose; Gluconeogenesis; Glycerol; Lactates; Liver; Male; Molsidomine; Nitric Oxide; Nitrites; Penicillamine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Shock, Septic | 1994 |
Alterations in coronary artery vascular reactivity of hypertensive Ren-2 transgenic rats.
Topics: Acetylcholine; Animals; Animals, Genetically Modified; Arginine; Coronary Vessels; Endothelium, Vascular; Hypertension; In Vitro Techniques; Molsidomine; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System | 1994 |
The opposing effects of an inhibitor of nitric oxide synthesis and of a donor of nitric oxide in rabbits undergoing myocardial ischemia reperfusion.
Topics: Analysis of Variance; Animals; Arginine; Blood Pressure; Heart; Molsidomine; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Necrosis; Nitric Oxide; Nitroarginine; Rabbits; Reference Values; Vasodilator Agents | 1994 |
Effect of nitric oxide-donor, linsidomine chlorhydrate, in treatment of human erectile dysfunction caused by venous leakage.
Topics: Adult; Aged; Alprostadil; Erectile Dysfunction; Humans; Male; Middle Aged; Molsidomine; Nitric Oxide; Vascular Diseases; Vasodilator Agents; Veins | 1993 |
Nitric oxide-releasing agents enhance cytokine-induced tumor necrosis factor synthesis in human mononuclear cells.
Topics: Humans; Interleukin-1; Leukocytes, Mononuclear; Lipopolysaccharides; Molsidomine; Nitric Oxide; Nitroprusside; Tumor Necrosis Factor-alpha | 1993 |
Differential sensitivity of proximal and distal coronary arteries to a nitric oxide donor following reperfusion injury or inhibition of nitric oxide synthesis.
Topics: Animals; Arginine; Coronary Vessels; Culture Techniques; Depression, Chemical; Dogs; Female; Male; Molsidomine; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide; Vasoconstriction; Vasodilation; Vasodilator Agents | 1993 |
Nitrate tolerance and aging in isolated rat aorta.
Topics: Aging; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Drug Tolerance; In Vitro Techniques; Male; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Phenylephrine; Rats; Rats, Wistar; Vasodilator Agents | 1993 |
Neuronal growth cone collapse and inhibition of protein fatty acylation by nitric oxide.
Topics: Acylation; Animals; Cells, Cultured; Cyclic GMP; Dibutyryl Cyclic GMP; Ganglia, Spinal; Hemoglobins; Molsidomine; Nerve Crush; Nerve Tissue Proteins; Neurites; Neurons; Nitric Oxide; Palmitic Acid; Palmitic Acids; PC12 Cells; Rats; Sciatic Nerve; Time Factors; Vasodilator Agents | 1993 |
Cytotoxicity of nitric oxide in Fu5 rat hepatoma cells: evidence for co-operative action with hydrogen peroxide.
Topics: Animals; Carcinoma, Hepatocellular; Catalase; Cell Line; Cell Survival; Glucose Oxidase; Hydrogen Peroxide; Kinetics; Liver Neoplasms; Molsidomine; Nitric Oxide; Nitroprusside; Penicillamine; Rats; S-Nitroso-N-Acetylpenicillamine; Superoxide Dismutase; Superoxides; Tumor Cells, Cultured; Vasodilator Agents; Xanthine Oxidase | 1993 |
Direct inhibition of platelet function by organic nitrates via nitric oxide formation.
Topics: Adenosine Triphosphate; Animals; Anisotropy; Blood Platelets; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Esters; Fibroblasts; Humans; Lung; Molsidomine; Nitrates; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Thromboxanes | 1993 |
Hypoxic mammalian cell radiosensitization by nitric oxide.
Topics: Animals; Cell Hypoxia; Cell Line; Cell Survival; Cricetinae; Cricetulus; Diethylamines; Hydrazines; Molsidomine; Neoplasms; Nitric Oxide; Nitrogen Oxides; Radiation-Sensitizing Agents | 1993 |
Nitric oxide-induced microvascular permeability alterations: a regulatory role for cGMP.
Topics: Animals; Arginine; Atrial Natriuretic Factor; Capillary Permeability; Cats; Cyclic GMP; Intestines; Methylene Blue; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Regional Blood Flow | 1993 |
Vascular relaxation and cyclic guanosine monophosphate in a rat model of high output heart failure.
Topics: Acetylcholine; Animals; Atrial Natriuretic Factor; Calcimycin; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Failure; Male; Molsidomine; Nitric Oxide; Rats; Rats, Wistar; Vasodilation | 1993 |
Changes in cytosolic cGMP and calcium in airway smooth muscle relaxed by 3-morpholinosydnonimine.
Topics: Animals; Calcium; Cyclic AMP; Cyclic GMP; Cytosol; Dogs; Female; In Vitro Techniques; Male; Methylene Blue; Molsidomine; Muscle Relaxation; Muscle, Smooth; Osmolar Concentration; Trachea | 1994 |
Assessment of coronary vasomotion by intracoronary ultrasound.
Topics: Aged; Blood Flow Velocity; Case-Control Studies; Cold Temperature; Coronary Artery Disease; Coronary Vessels; Echocardiography; Endothelium, Vascular; Female; Humans; Hypercholesterolemia; Male; Middle Aged; Molsidomine; Papaverine; Vasoconstriction; Vasodilation; Vasodilator Agents | 1993 |
Inhaled nitric oxide in pulmonary hypertension after total repair of total anomalous pulmonary venous return.
Topics: Administration, Inhalation; Antihypertensive Agents; Humans; Hypertension, Pulmonary; Infant; Male; Molsidomine; Nitric Oxide; Postoperative Complications; Pulmonary Veins | 1993 |
Local anesthetic drugs reduce endothelium-dependent relaxations of porcine ciliary arteries.
Topics: Anesthetics, Local; Animals; Arginine; Arteries; Ciliary Body; Endothelium, Vascular; Isometric Contraction; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Swine; Vasodilator Agents | 1993 |
Intracavernous application of SIN-I in rabbit and man: functional and toxicological results.
Topics: Animals; Blood Pressure; Culture Techniques; Dose-Response Relationship, Drug; Humans; Isometric Contraction; Male; Molsidomine; Muscle Relaxation; Penile Erection; Penis; Rabbits; Time Factors; Vasodilator Agents | 1993 |
Enzymic and nonenzymic release of NO accounts for the vasodilator activity of the metabolites of CAS 936, a novel long-acting sydnonimine derivative.
Topics: Animals; Blood Vessels; Cattle; Cyclic GMP; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; Female; In Vitro Techniques; Male; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Nitroso Compounds; Piperidines; Rabbits; Swine; Sydnones; Vasodilator Agents | 1993 |
Endothelial L-arginine pathway and relaxations to vasopressin in canine basilar artery.
Topics: Animals; Arginine; Basilar Artery; Cyclic GMP; Dogs; Endothelium, Vascular; In Vitro Techniques; Molsidomine; Nitric Oxide; Nitroarginine; Vasodilation; Vasopressins | 1993 |
The oxidation of alpha-tocopherol in human low-density lipoprotein by the simultaneous generation of superoxide and nitric oxide.
Topics: Acetaldehyde; Catalase; Free Radicals; Humans; Hydroxides; Hydroxyl Radical; Lipoproteins, LDL; Molsidomine; Nitric Oxide; Nitrogen Dioxide; Oxidation-Reduction; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Superoxide Dismutase; Superoxides; Thiobarbiturates; Vitamin E; Xanthine Oxidase | 1993 |
Nitric oxide donors reduce the rise in reperfusion-induced intestinal mucosal permeability.
Topics: Animals; Cats; Cyclic GMP; Intestinal Mucosa; Intestines; Ischemia; Molsidomine; Nitric Oxide; Nitroprusside; Permeability; Regional Blood Flow; Reperfusion Injury; Sydnones | 1993 |
A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds.
Topics: Animals; Brain; Cell Death; Cells, Cultured; Cysteine; Free Radicals; Molsidomine; Neurons; Nitrates; Nitric Oxide; Nitroglycerin; Nitroprusside; Oxidation-Reduction; Rats; Receptors, N-Methyl-D-Aspartate; S-Nitrosothiols; Superoxides | 1993 |
Pancreatic islet cells are highly susceptible towards the cytotoxic effects of chemically generated nitric oxide.
Topics: Animals; Cells, Cultured; Female; Islets of Langerhans; Male; Mice; Molsidomine; Nitric Oxide; Nitroprusside; Penicillamine; Rats; Rats, Inbred Lew; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Superoxides; Trypan Blue; Tumor Cells, Cultured | 1993 |
Inhibition by nitric oxide-donors of human polymorphonuclear leucocyte functions.
Topics: Cell Degranulation; Chemotaxis, Leukocyte; Cyclic AMP; Cyclic GMP; Glucuronidase; Humans; In Vitro Techniques; Leukotriene B4; Luminescent Measurements; Molsidomine; Neutrophils; Nitric Oxide; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Superoxides; Triazoles | 1993 |
Liberators of NO exert a dual effect on renin secretion from isolated mouse renal juxtaglomerular cells.
Topics: Animals; Cell Separation; Cyclic AMP; Cyclic GMP; Juxtaglomerular Apparatus; Mice; Molsidomine; Nitric Oxide; Nitroprusside; Renin | 1993 |
Actions of 3-morpholinosydnonimin (SIN-1) on rabbit isolated penile erectile tissue.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic GMP; Male; Molsidomine; Nitric Oxide; Nitroprusside; Penile Erection; Penis; Purinones; Rabbits; Vasodilator Agents | 1993 |
The effect of nitric oxide-donating vasodilators on monocyte chemotaxis and intracellular cGMP concentrations in vitro.
Topics: Cell Migration Inhibition; Chemotaxis, Leukocyte; Cyclic GMP; Humans; Isosorbide Dinitrate; Molsidomine; Monocytes; Nitroglycerin; Nitroprusside; Vasodilator Agents | 1993 |
Loss of alpha-tocopherol upon exposure to nitric oxide or the sydnonimine SIN-1.
Topics: Animals; Lipid Peroxides; Male; Microsomes, Liver; Molsidomine; Nitric Oxide; Quinones; Rats; Rats, Wistar; Vitamin E | 1993 |
SIN-1 reduces platelet adhesion and platelet thrombus formation in a porcine model of balloon angioplasty.
Topics: Angioplasty, Balloon; Animals; Blood Coagulation; Hemodynamics; Microscopy, Electron, Scanning; Molsidomine; Platelet Adhesiveness; Platelet Function Tests | 1993 |
Modification of energy metabolism and radiation response of a murine tumour by changes in nitric oxide availability.
Topics: Animals; Arginine; Biological Availability; Cell Hypoxia; Energy Metabolism; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C3H; Molsidomine; Neoplasm Transplantation; Neoplasms, Experimental; Nitric Oxide; Nitroarginine; Radiation Tolerance | 1993 |
Hyporesponsiveness to nitrovasodilators in rat aorta incubated with endotoxin and L-arginine.
Topics: Animals; Aorta; Arginine; Dose-Response Relationship, Drug; Drug Tolerance; Endotoxins; Male; Molsidomine; Nitroprusside; Rats; Rats, Wistar; Vasodilator Agents | 1995 |
Intestinal absorption of calcium in vivo is dependent on endogenous nitric oxide.
Topics: Animals; Arginine; Calcium; Female; Intestinal Absorption; Intestine, Small; Male; Mesenteric Veins; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Penicillamine; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents | 1995 |
A redox-based mechanism for induction of interleukin-1 production by nitric oxide in a human colonic epithelial cell line (HT29-Cl.16E).
Topics: Cell Line; Epithelium; Free Radicals; HT29 Cells; Humans; Interleukin-1; Kinetics; Molsidomine; Nitric Oxide; Nitroprusside; Oxidation-Reduction; Vasodilator Agents | 1996 |
Interaction of antiplatelet drugs in vitro: aspirin, iloprost, and the nitric oxide donors SIN-1 and sodium nitroprusside.
Topics: Adenosine Triphosphate; Aspirin; Blood Platelets; Cyclic AMP; Cyclic GMP; Drug Interactions; Humans; Iloprost; In Vitro Techniques; Iodine Radioisotopes; Molsidomine; Nitric Oxide; Nitroprusside; Phosphorylation; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors | 1995 |
Myocardial and coronary endothelial protective effects of acetylcholine after myocardial ischaemia and reperfusion in rats: role of nitric oxide.
Topics: Acetylcholine; Animals; Arginine; Blood Pressure; Coronary Vessels; Disease Models, Animal; Endothelium, Vascular; Heart Rate; In Vitro Techniques; Male; Molsidomine; Myocardial Infarction; Myocardial Ischemia; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Potassium Channel Blockers; Rats; Rats, Wistar; Vasodilator Agents | 1995 |
Modulation of iron regulatory protein functions. Further insights into the role of nitrogen- and oxygen-derived reactive species.
Topics: Aconitate Hydratase; Animals; Cell Line; Enzyme Inhibitors; Ferritins; Hemoglobins; Hydrogen Peroxide; Iron-Regulatory Proteins; Mice; Molsidomine; Nitrates; Reactive Oxygen Species; RNA-Binding Proteins; RNA, Messenger; Superoxide Dismutase; Superoxides | 1996 |
Inhibition of non-adrenergic non-cholinergic relaxations by nitric oxide donors.
Topics: Animals; Autonomic Nervous System; Electric Stimulation; Feedback; Gastric Fundus; In Vitro Techniques; Isometric Contraction; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitroglycerin; Rats; Rats, Wistar; Vasoactive Intestinal Peptide; Vasodilator Agents | 1995 |
Mediation by prostaglandins of the nitric oxide-induced neurogenic vasodilatation in rat skin.
Topics: Animals; Arginine; Bradykinin; Calcitonin Gene-Related Peptide; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female; Histamine; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Prostaglandins; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Skin; Skin Physiological Phenomena; Vasodilation; Vasodilator Agents | 1995 |
Nitric oxide mediates the anti-adrenergic effect of adenosine on calcium current in isolated rabbit atrioventricular nodal cells.
Topics: Adenosine; Adrenergic Antagonists; Animals; Arginine; Atrioventricular Node; Calcium Channels; Isoproterenol; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Purinergic P1 Receptor Antagonists; Rabbits; Xanthines | 1996 |
Nitric oxide donors induce extrusion of cyclic GMP from isolated human blood platelets by a mechanism which may be modulated by prostaglandins.
Topics: 1-Methyl-3-isobutylxanthine; Blood Platelets; Cells, Cultured; Culture Media; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Space; Guanylate Cyclase; Humans; Ion Transport; Molsidomine; Nitric Oxide; Ouabain; Penicillamine; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Probenecid; Prostaglandin D2; Prostaglandins; Prostaglandins A; Purinones; S-Nitroso-N-Acetylpenicillamine; Sodium-Potassium-Exchanging ATPase; Time Factors; Triazoles | 1995 |
Time-dependent increase in nitric oxide formation concurrent with vasodilation induced by sodium nitroprusside, 3-morpholinosydnonimine, and S-nitroso-N-acetylpenicillamine but not by glyceryl trinitrate.
Topics: Animals; Aorta, Thoracic; In Vitro Techniques; Luminescent Measurements; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitroglycerin; Nitroprusside; Penicillamine; Rabbits; S-Nitroso-N-Acetylpenicillamine; Time Factors; Vasodilation; Vasodilator Agents | 1995 |
Nitric oxide-dependent blood-brain barrier permeability alteration in the rat brain.
Topics: Animals; Arginine; Atropine; Blood Pressure; Blood-Brain Barrier; Heart Rate; Kinetics; Microcirculation; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Penicillamine; Permeability; Rats; Rats, Sprague-Dawley; Reference Values; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents | 1996 |
Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose.
Topics: Animals; Brain; Dithiothreitol; Electron Transport Complex IV; Glucose; Glutathione; Kinetics; Mitochondria; Molsidomine; Nitrates; Nitric Oxide; Oxygen Consumption; Rats; Submitochondrial Particles; Superoxide Dismutase | 1996 |
Nitric oxide stimulates the phosphorylation of rap1b in human platelets and acts synergistically with iloprost.
Topics: Blood Platelets; Electrophoresis, Polyacrylamide Gel; GTP-Binding Proteins; Humans; Iloprost; Kinetics; Molsidomine; Nitric Oxide; Penicillamine; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; rap GTP-Binding Proteins; S-Nitroso-N-Acetylpenicillamine | 1996 |
The chemistry and tumoricidal activity of nitric oxide/hydrogen peroxide and the implications to cell resistance/susceptibility.
Topics: Antineoplastic Agents; Antioxidants; Azoles; Catalase; Cell Death; Drug Resistance; Female; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Isoindoles; Macrophage Activation; Models, Biological; Molsidomine; Nitric Oxide; Organoselenium Compounds; Selenium; Superoxide Dismutase; Tumor Cells, Cultured | 1996 |
Nitric oxide attenuates vascular smooth muscle cell activation by interferon-gamma. The role of constitutive NF-kappa B activity.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aorta; Base Sequence; Binding Sites; Blotting, Northern; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Interleukin-1; Kinetics; Molecular Sequence Data; Molsidomine; Muscle, Smooth, Vascular; NF-kappa B; Nitric Oxide; Nitroprusside; Oligodeoxyribonucleotides; Promoter Regions, Genetic; Recombinant Proteins; RNA, Messenger; Saphenous Vein; Transcription Factors; Transcription, Genetic; Transfection; Tunica Media; Vascular Cell Adhesion Molecule-1 | 1996 |
Nitric oxide synthase (NOS3)-mediated cholinergic modulation of Ca2+ current in adult rabbit atrioventricular nodal cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Action Potentials; Animals; Arginine; Atrioventricular Node; Calcium Channels; Carbachol; Cyclic GMP; Immunohistochemistry; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rabbits; Receptors, Muscarinic | 1996 |
Nitric oxide-mediated cyclooxygenase activation. A key event in the antiplatelet effects of nitrovasodilators.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Animals; Aorta; Cattle; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Epoprostenol; Hemoglobins; Humans; Kinetics; Male; Methylene Blue; Models, Cardiovascular; Molsidomine; Nitric Oxide; Nitroglycerin; Nitroprusside; Penicillamine; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Vasodilation; Vasodilator Agents; Verapamil | 1996 |
Myocardial contractile response to nitric oxide and cGMP.
Topics: Animals; Cats; Cyclic GMP; Endothelium, Vascular; In Vitro Techniques; Molsidomine; Myocardial Contraction; Nitric Oxide; Nitroprusside; Penicillamine; Purinones; S-Nitroso-N-Acetylpenicillamine | 1996 |
Exogenous nitric oxide causes collapse of retinal ganglion cell axonal growth cones in vitro.
Topics: Animals; Axons; Cells, Cultured; Cysteine; Free Radical Scavengers; Mercaptoethanol; Molsidomine; Neurites; Nitrates; Nitric Oxide; Nitrites; Nitroprusside; Nitroso Compounds; Penicillamine; Retinal Ganglion Cells; S-Nitroso-N-Acetylpenicillamine; S-Nitrosothiols; Signal Transduction; Sulfhydryl Reagents; Time Factors; Vasodilator Agents; Xenopus laevis | 1996 |
Detection of nitrosylhemoglobin in liver allograft in rats by using near-infrared spectroscopy.
Topics: Animals; Biomarkers; Dose-Response Relationship, Drug; Graft Rejection; Hemoglobins; Immunosuppressive Agents; Liver Transplantation; Molsidomine; Rats; Rats, Inbred ACI; Rats, Inbred Lew; Tacrolimus; Transplantation, Homologous; Transplantation, Isogeneic; Vasodilator Agents | 1996 |
Nitric oxide reduces endothelial expression of intercellular adhesion molecule (ICAM)-1.
Topics: Analysis of Variance; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Gene Expression; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; Kinetics; Lipopolysaccharides; Molsidomine; Nitric Oxide; Umbilical Veins; Vasodilator Agents | 1996 |
Rat duodenum nitrergic-induced relaxations are cGMP-independent and apamin-sensitive.
Topics: 4-Aminopyridine; Animals; Apamin; Cyclic GMP; Cystamine; Duodenum; Hydroxylamines; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Nitric Oxide; Rats; Rats, Wistar; Tetraethylammonium Compounds | 1995 |
Decreased intraocular pressure induced by nitric oxide donors is correlated to nitrite production in the rabbit eye.
Topics: Acetonitriles; Animals; Aqueous Humor; Eye; Eye Proteins; Female; Injections; Intraocular Pressure; Molsidomine; Morpholines; Nitric Oxide; Nitrites; Ocular Hypotension; Penicillamine; Rabbits; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents; Vitreous Body | 1996 |
Effects of nitric oxide donor SIN-1 on oxygen availability and regional blood flow during endotoxic shock.
Topics: Animals; Blood Pressure; Cardiac Output; Dogs; Female; Hemodynamics; Male; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Regional Blood Flow; Shock, Septic; Stroke Volume; Vasodilator Agents; Ventricular Function, Left | 1996 |
Nitric oxide inhibits Epstein-Barr virus DNA replication and activation of latent EBV.
Topics: Blotting, Northern; Blotting, Southern; DNA Replication; Herpesvirus 4, Human; Molsidomine; Nitric Oxide; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Viral Proteins; Virus Latency; Virus Replication | 1995 |
Effects of KRN2391, a novel vasodilator acting as a nitrate and a K+ channel opener, on the rabbit lower urinary tract.
Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Electrophysiology; Female; Hypoglycemic Agents; Molsidomine; Muscle Relaxation; Muscle, Smooth; Pyridines; Pyrroles; Rabbits; Urethra; Vasodilator Agents | 1995 |
Increased guanylate cyclase activity is associated with an increase in cyclic guanosine 3',5'-monophosphate in left ventricular hypertrophy.
Topics: Animals; Arginine; Cyclic GMP; Dogs; Female; Guanylate Cyclase; Hypertrophy, Left Ventricular; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Oxygen Consumption | 1996 |
Standardization of coronary vasomotor tone with intracoronary nitroglycerin.
Topics: Blood Pressure; Calcium Channel Blockers; Case-Control Studies; Coronary Angiography; Coronary Disease; Coronary Vessels; Female; Humans; Male; Middle Aged; Molsidomine; Nisoldipine; Nitroglycerin; Reproducibility of Results; Time Factors; Vasodilation; Vasodilator Agents | 1996 |
Activation of a NO-cyclic GMP system by NO donors potentiates beta-endorphin-induced antinociception in the mouse.
Topics: Analgesics; Analgesics, Opioid; Animals; beta-Endorphin; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Molsidomine; Nitric Oxide; Nitroprusside; Pain Measurement; Rats | 1995 |
Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS.
Topics: Animals; Base Sequence; Blood Platelets; Cattle; Cell Adhesion Molecules; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Humans; In Vitro Techniques; Microfilament Proteins; Molecular Sequence Data; Molsidomine; Muscle, Smooth, Vascular; Norepinephrine; Phosphoproteins; Phosphorylation; Rats; Stereoisomerism; Thionucleotides; Vasoconstriction; Vasodilator Agents | 1995 |
Nitric oxide induces cultured cortical neuron apoptosis.
Topics: Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; DNA; Electrophoresis, Agar Gel; Glutathione; Molsidomine; Nerve Tissue Proteins; Neurons; Nitric Oxide; Nitroso Compounds; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione | 1996 |
Effects of 3-morpholinosydnonimine-N-ethylcarbamide on hypoxia-induced mechanical and electric responses of isolated pig coronary artery.
Topics: Animals; Coronary Vessels; Hypoxia; In Vitro Techniques; Membrane Potentials; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Swine; Vasodilator Agents | 1995 |
Nitric oxide donors decrease the function and survival of human pancreatic islets.
Topics: Adolescent; Adult; Animals; Cells, Cultured; Child; DNA Damage; Dose-Response Relationship, Drug; Glucose; Glutathione; Humans; Insulin; Iron Chelating Agents; Iron Compounds; Islets of Langerhans; Middle Aged; Molsidomine; Niacinamide; Nitric Oxide; Nitroso Compounds; Rats; S-Nitrosoglutathione; Succinates; Time Factors | 1996 |
Effects of nitric oxide donors sodium nitroprusside and 3-morpholino-sydnonimine on prolactin secretion in conscious rats.
Topics: Animals; Dose-Response Relationship, Drug; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Prolactin; Rats; Rats, Sprague-Dawley; Time Factors; Vasodilator Agents | 1996 |
Inhibition of purified (Na+,K+)-ATPase activity from porcine cerebral cortex by NO generating drugs.
Topics: Animals; Cerebral Cortex; Dithiothreitol; Enzyme Inhibitors; Molsidomine; Nitric Oxide; Nitro Compounds; Nitroprusside; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Sodium-Potassium-Exchanging ATPase; Sulfhydryl Reagents; Superoxide Dismutase; Swine | 1995 |
Enhanced NO production during Mg deficiency and its role in mediating red blood cell glutathione loss.
Topics: Animals; Electron Spin Resonance Spectroscopy; Erythrocytes; Glutathione; Hemoglobins; Magnesium Deficiency; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Weight Gain | 1996 |
Changes in energy metabolism and X-ray sensitivity in murine tumours by the nitric oxide donor SIN-1.
Topics: Animals; Dose-Response Relationship, Drug; Energy Metabolism; Female; Male; Mice; Mice, Inbred C3H; Molsidomine; Neoplasms, Experimental; Nitric Oxide; Radiation Tolerance | 1996 |
Inhibition of alveolar type II cell ATP and surfactant synthesis by nitric oxide.
Topics: Adenosine Triphosphate; Administration, Inhalation; Animals; Cells, Cultured; Molsidomine; Nitric Oxide; Nitrogen Oxides; Penicillamine; Pulmonary Alveoli; Pulmonary Surfactants; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Spermine | 1996 |
Peroxynitrite modulates receptor-activated Ca2+ signaling in vascular endothelial cells.
Topics: Animals; Bradykinin; Calcium; Cattle; Cells, Cultured; Endothelium, Vascular; Inositol 1,4,5-Trisphosphate; Molsidomine; Nitrates; Nitric Oxide; Receptors, Cell Surface; Signal Transduction | 1996 |
Negative inotropic actions of nitric oxide require high doses in rat cardiac muscle.
Topics: Animals; Calcium; Depression, Chemical; Enzyme Inhibitors; Heart; Hydrogen-Ion Concentration; Isoproterenol; Male; Molsidomine; Myocardial Contraction; Nitric Oxide; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Vasodilator Agents | 1996 |
A precursor of the nitric oxide donor SIN-1 modulates the stress protein heme oxygenase-1 in rat liver.
Topics: Animals; Blotting, Northern; Enzyme Induction; Female; Heat-Shock Proteins; Heme Oxygenase (Decyclizing); Humans; Kinetics; Liver; Molsidomine; Nitrates; Nitrites; Prodrugs; Rats; Rats, Inbred Lew; RNA, Messenger; Transcription, Genetic | 1996 |
NO-mediated activation of heme oxygenase: endogenous cytoprotection against oxidative stress to endothelium.
Topics: Animals; Bilirubin; Cell Line; Cell Survival; Endothelium, Vascular; Enzyme Activation; Enzyme Induction; Heme Oxygenase (Decyclizing); Hydrogen Peroxide; Male; Molsidomine; Nitric Oxide; Nitrites; Nitroprusside; Oxidative Stress; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Swine | 1996 |
Protection of reoxygenated cardiomyocytes against osmotic fragility by nitric oxide donors.
Topics: Animals; Antioxidants; Diacetyl; Enzyme Activation; Guanylate Cyclase; Hypoxia; Male; Molsidomine; Myocardium; Nitric Oxide; Nitroprusside; Osmotic Fragility; Oxygen; Penicillamine; Phenylenediamines; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine | 1996 |
Nitric oxide inhibits the initiation of cAMP pulsing in D. discoideum without altering receptor-activated adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Chemotaxis; Cyclic AMP; Dictyostelium; Enzyme Activation; Fungal Proteins; Molsidomine; Nitric Oxide; Nitroprusside; Periodicity; Receptors, Cyclic AMP; Second Messenger Systems; Secretory Rate | 1996 |
Nitric oxide donors suppress erythropoietin production in vitro.
Topics: Carcinoma, Hepatocellular; Cyclic GMP; Cytokines; Erythropoietin; Humans; Hydrogen Peroxide; Liver Neoplasms; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Penicillamine; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine; Tumor Cells, Cultured | 1996 |
Electrochemical methods for detection of nitric oxide.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Electrochemistry; Electrodes; Indicators and Reagents; Kinetics; Molsidomine; Nitric Oxide; Phosphites; Porphyrins; Sensitivity and Specificity; Superoxide Dismutase; Time Factors | 1996 |
Modification of macrophage glyceraldehyde-3-phosphate dehydrogenase in response to nitric oxide.
Topics: Aconitate Hydratase; Animals; Cell Death; Cells, Cultured; Glyceraldehyde-3-Phosphate Dehydrogenases; Macrophages; Mice; Molsidomine; NAD; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Sulfhydryl Reagents | 1996 |
NO decreases evoked quantal ACh release at a synapse of Aplysia by a mechanism independent of Ca2+ influx and protein kinase G.
Topics: Acetylcholine; Animals; Aplysia; Calcium; Electrophysiology; Enzyme Inhibitors; Ganglia, Invertebrate; Guanylate Cyclase; In Vitro Techniques; Ion Channel Gating; Membrane Potentials; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Patch-Clamp Techniques; Protein Kinase Inhibitors; Protein Kinases; Receptors, Presynaptic; Sodium-Potassium-Exchanging ATPase; Synapses; Synaptic Transmission | 1996 |
Inhibitory effect of nitric oxide on neuronal activity in the periaqueductal grey matter of the rat.
Topics: Animals; Antidotes; Electrophysiology; Glutathione; Guanylate Cyclase; Iontophoresis; Male; Methylene Blue; Molsidomine; NADPH Dehydrogenase; Neurons; Nitric Oxide; Nitroso Compounds; Periaqueductal Gray; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; S-Nitrosoglutathione | 1996 |
Antioxidant activity of diethyldithiocarbamate.
Topics: Animals; Antioxidants; Brain Chemistry; Deoxyribose; Ditiocarb; DNA Damage; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Humans; Hydroxyl Radical; Hypochlorous Acid; Iron; Lipoproteins, LDL; Molsidomine; Oxidation-Reduction; Rats | 1996 |
Nitration of surfactant protein A (SP-A) tyrosine residues results in decreased mannose binding ability.
Topics: Animals; Binding Sites; Free Radical Scavengers; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Lipid Peroxidation; Liposomes; Mannose; Molsidomine; Nitrates; Nitric Oxide; Oxidative Stress; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Superoxides; Tetranitromethane; Tyrosine | 1996 |
Regional specific effects of nitric oxide donors and cGMP on the electrical activity of neurons in the rat spinal cord.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Histocytochemistry; Male; Molsidomine; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Organ Culture Techniques; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Spinal Cord; Vasodilator Agents | 1996 |
Superoxide does not inhibit glyceryl trinitrate-rabbit aortic strip-mediated relaxation of rabbit Taenia coli. Evidence against a role for nitric oxide itself as the smooth muscle active drug metabolite?
Topics: Animals; Aorta, Thoracic; Biotransformation; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Oxidation-Reduction; Rabbits; Superoxides; Vasodilation; Vasodilator Agents; Xanthine; Xanthine Oxidase; Xanthines | 1996 |
Effects of NO-donors on thrombus formation and microcirculation in cerebral vessels of the rat.
Topics: Animals; Cerebrovascular Circulation; Fibrinolytic Agents; Intracranial Embolism and Thrombosis; Microcirculation; Molsidomine; Nitric Oxide; Nitroprusside; Rats; Rats, Wistar | 1996 |
Endothelial effects of hemostatic devices for continuous cardioplegia or minimally invasive operations.
Topics: Animals; Catheterization; Constriction; Coronary Vessels; Dinoprost; Endothelium, Vascular; Heart Arrest, Induced; Hemostasis, Surgical; In Vitro Techniques; Minimally Invasive Surgical Procedures; Molsidomine; Myocardial Revascularization; Potassium Chloride; Serotonin; Surgical Instruments; Swine; Vasoconstriction; Vasodilator Agents | 1996 |
Effect of ITF 296 on total effective vascular compliance in the anesthetized dog under autonomic blockade.
Topics: Anesthesia; Animals; Autonomic Nerve Block; Benzoxazines; Blood Pressure; Dogs; Female; Hemodynamics; Male; Molsidomine; Muscle Tonus; Nitrates; Nitroglycerin; Oxazines; Vascular Resistance; Vasodilator Agents | 1995 |
The nitrate ester ITF 296 relaxes isolated canine arteries and veins.
Topics: Animals; Arteries; Benzoxazines; Dogs; Electrophysiology; Endothelium, Vascular; Female; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrates; Nitroglycerin; Oxazines; Vasodilator Agents; Veins | 1995 |
Differential hemodynamic effects of the nitric oxide donor pirsidomine in comparison to SIN-1, nitroprusside and nitroglycerin.
Topics: Animals; Blood Pressure; Dogs; Heart Rate; Hemodynamics; Injections, Intravenous; Molsidomine; Nitric Oxide; Nitroglycerin; Nitroprusside; Sydnones; Vasodilator Agents | 1996 |
Preconditioning prevents chronic reperfusion-induced coronary endothelial dysfunction in rats.
Topics: Acetylcholine; Animals; Chronic Disease; Coronary Circulation; Coronary Vessels; Endothelium, Vascular; Ischemic Preconditioning, Myocardial; Male; Microscopy, Electron; Molsidomine; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Serotonin; Vasoconstriction; Vasodilator Agents | 1996 |
Differential effects of nitric oxide donors on basal and electrically evoked release of acetylcholine from guinea-pig myenteric neurones.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; Guinea Pigs; Male; Molsidomine; Myenteric Plexus; Nitric Oxide | 1996 |
Role of sarcoplasmic reticulum in inhibitory junction potentials and hyperpolarizations by nitric oxide donors in opossum oesophagus.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Esophagus; Female; Male; Membrane Potentials; Molsidomine; Nitric Oxide; Nitroprusside; Opossums; Sarcoplasmic Reticulum | 1996 |
Synergistic inhibition of human polymorphonuclear function by prostaglandin E1 and linsidomine.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Cyclic AMP; Drug Synergism; Humans; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Respiratory Burst | 1996 |
Role of oxygen free radicals in cardiocyte injury in the reperfused rat heart.
Topics: Animals; Endothelium; Free Radical Scavengers; Glycocalyx; Heart; Male; Molsidomine; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Wistar; Reactive Oxygen Species; Tiopronin; Vasodilator Agents | 1996 |
Inhibition of beta- but not alpha 1-mediated adrenergic responses in isolated hearts and cardiomyocytes by nitric oxide and 8-bromo cyclic GMP.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Calcium; Cell Size; Cells, Cultured; Cyclic GMP; Isoproterenol; Male; Molsidomine; Myocardial Contraction; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Penicillamine; Perfusion; Phenylephrine; Propranolol; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Stimulation, Chemical; Vasodilator Agents | 1996 |
Involvement of nitric oxide in cardiorespiratory regulation in the nucleus tractus solitarii.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Male; Molsidomine; Nitric Oxide; Rats; Rats, Sprague-Dawley; Respiration; Solitary Nucleus | 1996 |
Vasodilator responses to nitric oxide are enhanced in mesenteric arteries of portal hypertensive rats.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Hypertension, Portal; Male; Mesenteric Arteries; Molsidomine; Nitric Oxide; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 1996 |
Regulation of Ca(2+)-activated K+ channels in pulmonary vascular smooth muscle cells: role of nitric oxide.
Topics: Calcium; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Membrane Potentials; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Potassium Channels; Pulmonary Circulation | 1996 |
Inhibition of pleural mesothelial cell collagen synthesis by nitric oxide.
Topics: Animals; Cell Line; Collagen; Cytokines; Epithelial Cells; Epithelium; Free Radicals; Inflammation Mediators; Lipopolysaccharides; Molsidomine; Nitric Oxide; Penicillamine; Pleura; Rats; S-Nitroso-N-Acetylpenicillamine | 1996 |
Nitric oxide inhibits DNA synthesis and induces activation of poly(ADP-ribose) polymerase in cultured rat hepatocytes.
Topics: Animals; Cells, Cultured; DNA; Enzyme Activation; Hepatocyte Growth Factor; Kinetics; Liver; Mitosis; Molsidomine; Nitric Oxide; Nitroprusside; Poly(ADP-ribose) Polymerases; Rats | 1996 |
Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols.
Topics: Animals; Calcium Channels; Extracellular Space; Ferrets; Heart Ventricles; Male; Molsidomine; Myocardium; Nitric Oxide; Nitroso Compounds; Oxidation-Reduction; Patch-Clamp Techniques; Sulfhydryl Compounds | 1996 |
Protection from nicotinamide inhibition of interleukin-1 beta-induced RIN cell nitric oxide formation is associated with induction of MnSOD enzyme activity.
Topics: Animals; Antioxidants; Cell Line; Enzyme Induction; Humans; Interleukin-1; Islets of Langerhans; Kinetics; Molsidomine; Niacinamide; Nitric Oxide; Nitric Oxide Synthase; Pyrrolidines; Recombinant Proteins; Superoxide Dismutase; Superoxides; Thiocarbamates; Time Factors; Vasodilator Agents | 1996 |
Nitric oxide donor SIN-1 inhibits insulin release.
Topics: Aluminum Compounds; Animals; Calcium-Transporting ATPases; Carbachol; Cells, Cultured; Colforsin; Cyclic AMP; Dithiothreitol; Fluorides; Glucose; GTP-Binding Proteins; Insulin; Insulin Secretion; Islets of Langerhans; Molsidomine; Nitric Oxide; Oxidation-Reduction; Potassium Chloride; Protein Kinase C; Rats; Rats, Wistar; Secretory Rate; Signal Transduction; Tetradecanoylphorbol Acetate | 1996 |
Regulation of VIP release from rat enteric nerve terminals: evidence for a stimulatory effect of NO.
Topics: Animals; Arginine; Calcium; Cell Fractionation; Cyclic GMP; Intestine, Small; Membrane Potentials; Molsidomine; NADPH Dehydrogenase; Nerve Endings; Nitric Oxide; Nitroprusside; Protein Kinase C; Rats; Rats, Wistar; Synaptosomes; Tetradecanoylphorbol Acetate; Vasoactive Intestinal Peptide | 1996 |
Permissive and obligatory roles of NO in cerebrovascular responses to hypercapnia and acetylcholine.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Animals; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Hypercapnia; Indazoles; Male; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Papaverine; Prosencephalon; Rats; Rats, Sprague-Dawley; Vasodilation | 1996 |
The effects of nitric oxide (NO) on platelet membrane receptor expression during activation with human alpha-thrombin.
Topics: Blood Platelets; Down-Regulation; Humans; Molsidomine; Nitric Oxide; P-Selectin; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombin; Up-Regulation | 1996 |
Recovery of endothelium-dependent relaxations four weeks after ischemia and progressive reperfusion in canine coronary arteries.
Topics: Acetylcholine; Adenosine Diphosphate; Animals; Arteries; Bradykinin; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Reperfusion Injury; Serotonin; Thrombin; Time Factors | 1996 |
Oxidation of human low-density lipoprotein by soybean 15-lipoxygenase in combination with copper (II) or met-myoglobin.
Topics: Arachidonate 15-Lipoxygenase; Copper; Drug Synergism; Glycine max; Humans; Lipoproteins, LDL; Metmyoglobin; Molsidomine; Oxidation-Reduction | 1996 |
Oxygen-dependent reversible inhibition of mitochondrial respiration by nitric oxide.
Topics: Animals; Cell Respiration; Cytochromes; Electron Transport; Male; Mitochondria; Molsidomine; Nitric Oxide; Nitroso Compounds; Oxygen; Rats; Rats, Wistar | 1996 |
Nitric oxide inhibits intracellular adhesion molecule-1 expression in rat mesangial cells.
Topics: Animals; Antibodies, Monoclonal; Cells, Cultured; Cyclic GMP; Enzyme-Linked Immunosorbent Assay; Free Radical Scavengers; Glomerular Mesangium; Intercellular Adhesion Molecule-1; Interleukin-1; Male; Molsidomine; Nitric Oxide; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1996 |
Nitric oxide donors SIN-1 and SNAP promote nonrapid-eye-movement sleep in rats.
Topics: Animals; Body Temperature; Electroencephalography; Enzyme Inhibitors; Male; Molsidomine; Motor Activity; Nitric Oxide; Penicillamine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Sleep; Sodium-Potassium-Exchanging ATPase | 1996 |
The role of sarcoplasmic reticulum and sarcoplasmic reticulum Ca2+-ATPase in the smooth muscle tone of the cat gastric fundus.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Apamin; Calcium Channel Agonists; Calcium Channel Blockers; Calcium-Transporting ATPases; Cats; Cinnarizine; Enzyme Inhibitors; Gastric Fundus; In Vitro Techniques; Indoles; Male; Molsidomine; Muscle Contraction; Muscle, Smooth; Nifedipine; Nitroprusside; Potassium Channel Blockers; Sarcoplasmic Reticulum; Thapsigargin | 1996 |
Peroxynitrite augments fMLP-stimulated chemiluminescence by neutrophils in human whole blood.
Topics: Antioxidants; Azides; Benzoquinones; Catalase; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Free Radical Scavengers; Humans; Lipoxygenase Inhibitors; Luminescent Measurements; Luminol; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitrates; Nitric Oxide; omega-N-Methylarginine; Proadifen; Reactive Oxygen Species; Respiratory Burst; Sodium Azide; Superoxide Dismutase; Taurine | 1996 |
Cytokine modulation of glial glutamate uptake: a possible involvement of nitric oxide.
Topics: Animals; Animals, Newborn; Biological Transport; Cells, Cultured; Cytokines; Enzyme Inhibitors; Glutamic Acid; Hippocampus; Humans; Interferon-gamma; Interleukin-1; Kinetics; Molsidomine; Neuroglia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Penicillamine; Rats; Rats, Sprague-Dawley; Recombinant Proteins; S-Nitroso-N-Acetylpenicillamine; Tumor Necrosis Factor-alpha | 1996 |
DNA damage by peroxynitrite characterized with DNA repair enzymes.
Topics: Butanols; Chromatography, High Pressure Liquid; DNA; DNA Damage; DNA Repair; Endonucleases; Free Radical Scavengers; Hydroxyl Radical; Molsidomine; Nitrates; tert-Butyl Alcohol | 1996 |
The involvement of nitric oxide in the anti-Candida albicans activity of rat neutrophils.
Topics: Animals; Candida albicans; Cytochalasin B; Lipopolysaccharides; Male; Molsidomine; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Wistar; Superoxides; Tetradecanoylphorbol Acetate; Vasodilator Agents | 1996 |
Effects of organotypic culture on parasympathetic innervation of guinea pig trachealis.
Topics: Analysis of Variance; Animals; Atropine; Electric Stimulation; Enzyme Inhibitors; Esophagus; Guinea Pigs; Male; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myenteric Plexus; Nerve Fibers; Neurons; Nitric Oxide Synthase; Nitroarginine; Organ Culture Techniques; Parasympathetic Nervous System; Trachea; Vagus Nerve; Vasoactive Intestinal Peptide | 1996 |
Oxidant stress stimulates mucin secretion and PLC in airway epithelium via a nitric oxide-dependent mechanism.
Topics: Animals; Cell Transformation, Viral; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Epithelium; Guinea Pigs; Humans; Hydrogen Peroxide; Molsidomine; Mucins; Nitric Oxide; omega-N-Methylarginine; Penicillamine; Peroxides; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine; Superoxides; tert-Butylhydroperoxide; Trachea; Type C Phospholipases; Xanthine Oxidase | 1996 |
Effect of intracerebroventricular and intravenous administration of nitric oxide donors on blood pressure and heart rate in anaesthetized rats.
Topics: Animals; Blood Pressure; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart Rate; Injections, Intravenous; Injections, Intraventricular; Male; Molsidomine; Nitric Oxide; Nitroprusside; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Triazoles | 1996 |
Nitric oxide influences the release of histamine and glutamate in the rat hypothalamus.
Topics: Animals; Diethylamines; Glutamic Acid; Histamine Release; Hypothalamus; Male; Molsidomine; Nitric Oxide; Nitrogen Oxides; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Intracavernous injection of linsidomine chlorhydrate in monkeys: lack of toxic effect with long-term use.
Topics: Animals; Blood Pressure; Hypotension; Macaca fascicularis; Macaca nemestrina; Male; Molsidomine; Penile Erection; Penis; Vasodilator Agents | 1996 |
Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copper.
Topics: Amidines; Butylated Hydroxytoluene; Copper; Hydroxycholesterols; Ketocholesterols; Lipoproteins, LDL; Molsidomine; Molybdenum; Myoglobin; Nitrates; Oxidation-Reduction; Superoxide Dismutase; Vitamin E | 1996 |
Endogenous nitric oxide and prostaglandin E2 do not regulate the synthesis of each other in interleukin-1 beta-stimulated rat articular cartilage.
Topics: Animals; Aspirin; Cartilage, Articular; Dexamethasone; Dinoprostone; Electron Transport Complex IV; Interleukin-1; Ketoprofen; Kinetics; Male; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Organ Culture Techniques; Ornithine; Prostaglandin Antagonists; Rats; Rats, Wistar; Triazoles | 1996 |
Evidence that potassium channels make a major contribution to SIN-1-evoked relaxation of rat isolated mesenteric artery.
Topics: Animals; Cyclic GMP; Endothelium, Vascular; In Vitro Techniques; Male; Mesenteric Arteries; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Rats; Rats, Wistar; Superoxide Dismutase; Vasodilator Agents | 1996 |
Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis.
Topics: Animals; Arachidonic Acid; Cell Line; Enzyme Activation; Glutathione Peroxidase; Kinetics; Macrophages; Metalloporphyrins; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Salicylates; Superoxides | 1996 |
Nitric oxide involvement in Hydra vulgaris very primitive olfactory-like system.
Topics: Animals; Calcium; Calmodulin; Cyclic GMP; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Feeding Behavior; Hydra; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitroprusside; Olfactory Pathways | 1997 |
Nitric oxide reduces basal efflux of catecholamines from perfused dog adrenal glands.
Topics: Adrenal Glands; Animals; Catecholamines; Dogs; Enkephalin, Methionine; Enzyme Inhibitors; Female; In Vitro Techniques; Male; Molsidomine; Neuropeptides; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Perfusion; Sodium-Potassium-Exchanging ATPase | 1996 |
In-vitro bronchorelaxing effects of novel nitric oxide donors GEA 3268 and GEA 5145 in guinea-pigs and rats.
Topics: Albuterol; Animals; Bronchodilator Agents; Cyclic GMP; Female; Guinea Pigs; In Vitro Techniques; Male; Mesenteric Arteries; Molsidomine; Nitric Oxide; Nitroprusside; Rats; Rats, Wistar; Triazoles | 1996 |
Cyclopiazonic acid-induced changes in contractile activity of smooth muscle strips isolated from cat and guinea-pig stomach.
Topics: Acetylcholine; Animals; Calcium; Calcium-Transporting ATPases; Cats; Guinea Pigs; In Vitro Techniques; Indoles; Molsidomine; Muscle Contraction; Muscle, Smooth; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Stomach; Time Factors; Vasodilator Agents | 1996 |
A possible role for nitric oxide in the regulation of human ureteral smooth muscle tone in vitro.
Topics: Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Humans; Immunohistochemistry; In Vitro Techniques; Molsidomine; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Nitric Oxide; Potassium Chloride; Thionucleotides; Ureter | 1996 |
The effect of a nitric oxide donor and an inhibitor of nitric oxide synthase on blood flow and vascular resistance in feline submandibular, parotid and pancreatic glands.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Cats; Endothelium, Vascular; Enzyme Inhibitors; Exocrine Glands; Hemodynamics; Male; Molsidomine; Nerve Fibers; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Pancreas; Parotid Gland; Regional Blood Flow; Submandibular Gland; Vascular Resistance; Vasodilator Agents | 1996 |
Postnatal retinal ganglion cells in vitro: protection against reactive oxygen species (ROS)-induced axonal degeneration by cocultured astrocytes.
Topics: Animals; Ascorbic Acid; Astrocytes; Axons; Coculture Techniques; Free Radical Scavengers; Iron; Molsidomine; Nerve Degeneration; Neurites; Neuroprotective Agents; Rats; Reactive Oxygen Species; Reference Values; Retinal Ganglion Cells; Vitamin E | 1996 |
Nitric oxide-releasing agents and cGMP analogues inhibit murine erythroleukemia cell differentiation and suppress erythroid-specific gene expression: correlation with decreased DNA binding of NF-E2 and altered c-myb mRNA expression.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Animals; Base Sequence; Cell Differentiation; Cell Line; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Cyclic GMP; Dimethyl Sulfoxide; DNA-Binding Proteins; Erythroid-Specific DNA-Binding Factors; GATA1 Transcription Factor; Gene Expression Regulation, Neoplastic; Globins; Leukemia, Erythroblastic, Acute; Mice; Molecular Sequence Data; Molsidomine; NF-E2 Transcription Factor; NF-E2 Transcription Factor, p45 Subunit; Nitric Oxide; Nuclear Proteins; Oligonucleotide Probes; Oncogenes; Phosphodiesterase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myb; Purinones; Recombinant Proteins; RNA, Messenger; Thionucleotides; Trans-Activators; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1995 |
Quantification of peroxynitrite, superoxide, and peroxyl radicals by a new spin trap hydroxylamine 1-hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine.
Topics: Amidines; Dimethyl Sulfoxide; Electron Spin Resonance Spectroscopy; Free Radicals; Kinetics; Molsidomine; Nitrates; Peroxides; Piperidines; Reactive Oxygen Species; Spin Labels; Superoxides; Triacetoneamine-N-Oxyl | 1997 |
Regulation of rat liver S-adenosylmethionine synthetase during septic shock: role of nitric oxide.
Topics: Animals; Lipopolysaccharides; Liver; Methionine Adenosyltransferase; Molsidomine; Nitric Oxide; Rats; Rats, Wistar; Shock, Septic | 1997 |
L-arginine reduces human monocyte adhesion to vascular endothelium and endothelial expression of cell adhesion molecules.
Topics: Arginine; Blotting, Northern; Cell Adhesion; Cells, Cultured; Drug Combinations; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Molsidomine; Monocytes; omega-N-Methylarginine; Vascular Cell Adhesion Molecule-1 | 1997 |
Effects of sodium nitroprusside in the rat cortical collecting duct are independent of the NO pathway.
Topics: Animals; Arginine Vasopressin; Cyclic GMP; Enzyme Inhibitors; Female; In Vitro Techniques; Kidney Cortex; Kidney Tubules, Collecting; Membrane Potentials; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Perfusion; Potassium Channels; Rats; Rats, Wistar | 1997 |
Nitric oxide (NO) donor 3-morpholinosydnonimine antagonizes cyclosporin A-induced contraction in two in vitro glomerular models.
Topics: Animals; Cell Adhesion; Cell Size; Cells, Cultured; Cyclosporine; Enzyme Inhibitors; Glomerular Mesangium; Image Processing, Computer-Assisted; Kidney Glomerulus; Molsidomine; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Organ Culture Techniques; Rats; Rats, Sprague-Dawley | 1996 |
Dual role of cGMP in modulation of macromolecule permeability of aortic endothelial cells.
Topics: Animals; Aorta; Atrial Natriuretic Factor; Calcium; Capillary Permeability; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Extracellular Space; Guanylate Cyclase; Macromolecular Substances; Molsidomine; Serum Albumin; Stimulation, Chemical; Swine | 1997 |
Endothelium-dependent pulmonary vasodilation is selectively attenuated during isoflurane anesthesia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Anesthesia; Animals; Blood Pressure; Bradykinin; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Gases; Halothane; Hemodynamics; Homeostasis; Isoflurane; Male; Molsidomine; Nitroprusside; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Thromboxane A2; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 1997 |
Role of potassium channels in relaxations of isolated canine basilar arteries to acidosis.
Topics: 4-Aminopyridine; Acidosis; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Barium Compounds; Basilar Artery; Calcium Channel Blockers; Charybdotoxin; Chlorides; Dogs; Endothelium, Vascular; Female; Glyburide; Hydrogen-Ion Concentration; Ion Channel Gating; KATP Channels; Male; Molsidomine; Muscle, Smooth, Vascular; Potassium Channels; Potassium Channels, Inwardly Rectifying; Uridine Triphosphate; Vasodilation | 1997 |
Morphological and functional evidence against a sensory and sympathetic origin of nitric oxide synthase-containing nerves in the rat lower urinary tract.
Topics: Acetylcholinesterase; Animals; Antibody Specificity; Arginine Vasopressin; Calcitonin Gene-Related Peptide; Capsaicin; Enzyme Inhibitors; Female; Gold Colloid; Microscopy, Electron; Molsidomine; Neurons, Afferent; Neuropeptide Y; Nitric Oxide Synthase; Nitroarginine; Oxidopamine; Rats; Rats, Sprague-Dawley; Substance P; Sympathectomy, Chemical; Sympathetic Fibers, Postganglionic; Sympatholytics; Tyrosine 3-Monooxygenase; Urethra; Urothelium; Vasoconstrictor Agents; Vasodilator Agents | 1997 |
Nitric oxide attenuates adhesion molecule expression in human endothelial cells.
Topics: Cell Adhesion; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Interleukin-1; Molsidomine; Nitric Oxide; RNA, Messenger; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 1996 |
Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery.
Topics: Animals; Basilar Artery; Calcimycin; Chelating Agents; Cyclic GMP; Dogs; Egtazic Acid; Enzyme Inhibitors; Gene Expression; Immunohistochemistry; In Vitro Techniques; Ionophores; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Recombinant Proteins; Transfection; Uridine Triphosphate; Vasodilation; Vasodilator Agents | 1997 |
Evidence for peroxynitrite as an oxidative stress-inducing compound of aqueous cigarette smoke fractions.
Topics: 3T3 Cells; Animals; Catalase; Enzyme Induction; Gene Expression; Genes, fos; Glutathione; Guanylate Cyclase; Mice; Molsidomine; Nicotiana; Nitrates; Nitric Oxide; Oxidative Stress; Plants, Toxic; Rats; Smoke; Superoxide Dismutase | 1997 |
Negative metabolic effects of cyclic GMP are altered in renal hypertension induced cardiac hypertrophy.
Topics: Animals; Blood Gas Analysis; Cardiomegaly; Coronary Circulation; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Hemodynamics; Hypertension, Renovascular; Molsidomine; Myocardium; Oxygen; Rabbits | 1997 |
Nitric oxide acts in conjunction with proinflammatory cytokines to promote cell death in osteoblasts.
Topics: Animals; Bone Remodeling; Cell Death; Cell Line; Coculture Techniques; Glutathione; Hormones; Humans; Interferon-gamma; Interleukin-1; Mice; Molsidomine; Nitric Oxide; Nitroso Compounds; Osteoblasts; Penicillamine; Recombinant Proteins; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Tumor Necrosis Factor-alpha | 1997 |
Effect of chronic treatment with 17beta-estradiol and progesterone on endothelium-dependent and endothelium-independent relaxation in isolated aortic rings from ovariectomized rats.
Topics: Acetylcholine; Animals; Aorta; Endothelium, Vascular; Estradiol; Female; In Vitro Techniques; Indomethacin; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Ovariectomy; Progesterone; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 1997 |
Nitric oxide donor SIN-1 mediated down-regulation of the G-protein alpha-subunit in C6 glioma cells.
Topics: Adenosine Diphosphate Ribose; Animals; Blotting, Northern; Cholera Toxin; Cyclic N-Oxides; Down-Regulation; Enzyme Inhibitors; Glioma; GTP-Binding Proteins; Imidazoles; Molsidomine; Nitric Oxide; Rats; RNA, Messenger; Tumor Cells, Cultured | 1997 |
Photoactivation of the nitric oxide donor SIN-1.
Topics: Molsidomine; Nitric Oxide; Nitroprusside; Photochemistry | 1997 |
Mechanisms of arginine-induced increase in cytosolic calcium concentration in the beta-cell line NIT-1.
Topics: Animals; Arginine; Calcium; Cell Line; Cytosol; Diazoxide; Homoarginine; Insulin; Insulin Secretion; Insulinoma; Kinetics; Mice; Mice, Transgenic; Molsidomine; Nitric Oxide; Nitroarginine; omega-N-Methylarginine; Pancreatic Neoplasms; Potassium Channels; Potassium Chloride; Tumor Cells, Cultured; Verapamil | 1997 |
Mode of cytostatic action of mesoionic oxatriazole nitric oxide donors in proliferating human hematopoietic cells.
Topics: Antineoplastic Agents; Cell Division; Cell Membrane Permeability; Cell Size; DNA, Neoplasm; Hematopoietic Stem Cells; Humans; Leukemia-Lymphoma, Adult T-Cell; Molsidomine; Neoplasm Proteins; Nitric Oxide; Platelet Aggregation Inhibitors; RNA, Neoplasm; Triazoles; Tumor Cells, Cultured | 1997 |
Reactions of peroxynitrite with gamma-tocopherol.
Topics: Magnetic Resonance Spectroscopy; Molsidomine; Nitrates; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Vitamin E | 1997 |
Characterization of the isoenzymes of cyclic nucleotide phosphodiesterase in human platelets and the effects of E4021.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Blood Platelets; Cyclic Nucleotide Phosphodiesterases, Type 5; Humans; In Vitro Techniques; Isoenzymes; Molsidomine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phthalazines; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinazolines; Signal Transduction; Thromboxane A2; Tissue Distribution | 1996 |
Nitric oxide induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle cells.
Topics: Animals; Carbon Monoxide; Cells, Cultured; Cyclic GMP; Cycloheximide; Cytokines; Dactinomycin; Enzyme Inhibitors; Gene Expression Regulation; Heme Oxygenase (Decyclizing); Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Penicillamine; Rats; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Time Factors; Transcription, Genetic | 1997 |
Interference of carboxy-PTIO with nitric oxide- and peroxynitrite-mediated reactions.
Topics: Animals; Benzoates; Cattle; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Free Radical Scavengers; Imidazoles; Kinetics; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Serum Albumin, Bovine; Swine; Tyrosine | 1997 |
Release of glutathione from erythrocytes and other markers of oxidative stress in carbon monoxide poisoning.
Topics: Animals; Biological Transport; Biomarkers; Blood Platelets; Carbon Monoxide Poisoning; Cytochalasin B; Enzyme Inhibitors; Erythrocyte Count; Erythrocyte Membrane; Erythrocytes; Glutathione; Glutathione Disulfide; Hexoses; Male; Molsidomine; Neutrophils; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 1997 |
Nitric oxide inhibits the secretion of T-helper 1- and T-helper 2-associated cytokines in activated human T cells.
Topics: CD3 Complex; Cell Culture Techniques; Cell Division; Cytokines; Humans; Lymphocyte Activation; Molsidomine; Nitric Oxide; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Th1 Cells; Th2 Cells | 1997 |
Obligatory role of NO in glutamate-dependent hyperemia evoked from cerebellar parallel fibers.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cerebellum; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Glutamic Acid; Hyperemia; Indazoles; Male; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxygen; Papaverine; Partial Pressure; Penicillamine; Rats; Rats, Sprague-Dawley; Regional Blood Flow; S-Nitroso-N-Acetylpenicillamine; Vasodilation | 1997 |
Nitric oxide and effects of cationic polypeptides in canine cerebral arteries.
Topics: Animals; Basilar Artery; Bradykinin; Calcimycin; Dogs; Endothelium, Vascular; Female; In Vitro Techniques; Male; Molsidomine; Nitric Oxide; Peptides; Polylysine; Vasoconstriction; Vasodilation; Vasodilator Agents | 1997 |
Sensitivity of human hepatocytes in culture to reactive nitrogen intermediates.
Topics: Cells, Cultured; Enzyme Inhibitors; Humans; In Vitro Techniques; Liver; Molsidomine; Nitrites; Nitrogen; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Sodium-Potassium-Exchanging ATPase; Tyrosine | 1997 |
3-Morpholino-sydnonimine-induced suppression of human neutrophil degranulation is not mediated by cyclic GMP, nitric oxide or peroxynitrite: inhibition of the increase in intracellular free calcium concentration by N-morpholino-iminoacetonitrile, a metabo
Topics: Acetonitriles; Calcium; Cell Degranulation; Cyclic GMP; Humans; Molsidomine; Morpholines; Neutrophils; Nitrates; Nitric Oxide | 1997 |
Cerebrovascular effects of nitric oxide manipulation in spontaneously hypertensive rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Autoradiography; Blood Pressure; Cerebrovascular Circulation; Disease Models, Animal; Hypertension; Indazoles; Infusions, Intravenous; Injections, Intravenous; Isotope Labeling; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation; Vasodilator Agents | 1997 |
Suppression of the oxidative burst in murine microglia by nitric oxide.
Topics: Animals; Animals, Newborn; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Interferon-gamma; Interleukin-1; Kinetics; Luminescent Measurements; Mice; Microglia; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Penicillamine; Respiratory Burst; S-Nitroso-N-Acetylpenicillamine; Superoxides | 1997 |
Regulation of MHC class I expression by inflammatory cytokines in rat mesangial cells.
Topics: Animals; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Fluorescent Antibody Technique; Glomerular Mesangium; Histocompatibility Antigens Class II; Humans; Interferon-gamma; Interleukin-1; Male; Molsidomine; Nitric Oxide; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 1997 |
3-Morpholinosydnonimine as instigator of a glibenclamide-sensitive reduction in the insulin secretory rate.
Topics: Animals; Calcium Channels; Down-Regulation; Drug Interactions; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Molsidomine; Potassium Channels; Rats; Rats, Wistar; Secretory Rate | 1997 |
Role of potassium channels in relaxations of canine middle cerebral arteries induced by nitric oxide donors.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; 4-Aminopyridine; Animals; Barium Compounds; Cerebral Arteries; Charybdotoxin; Chlorides; Cyclic GMP; Diltiazem; Dogs; Glyburide; In Vitro Techniques; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Potassium Channels; Purinones; Vasodilation; Vasodilator Agents | 1997 |
Nitric oxide synergistically enhances DNA strand breakage induced by polyhydroxyaromatic compounds, but inhibits that induced by the Fenton reaction.
Topics: Catechols; Copper; DNA Damage; Drug Synergism; Hydrogen Peroxide; Hydroquinones; Iron; Molsidomine; Nitrates; Nitric Oxide; Plasmids; Reactive Oxygen Species | 1997 |
An assay of neutrophil adhesion to fibronectin and its attenuation by pentoxifylline and nitric oxide.
Topics: Cell Adhesion; Fibronectins; Humans; In Vitro Techniques; Lipopolysaccharides; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentoxifylline | 1997 |
Opposite effects of nitric oxide on identified inhibitory and excitatory cholinergic synapses of Aplysia californica.
Topics: Acetylcholine; Action Potentials; Animals; Aplysia; Arginine; Calcium Channels; Cholinergic Agonists; Cholinergic Antagonists; Cyclic GMP; Ganglia, Invertebrate; Ganglia, Parasympathetic; Guanylate Cyclase; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Potassium Channels; Synapses; Synaptic Transmission | 1996 |
Subarachnoid hemorrhage impairs cerebral blood flow response to nitric oxide but not to cyclic GMP in large cerebral arteries.
Topics: Animals; Brain; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circulation; Cyclic GMP; Injections, Intra-Articular; Male; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Papaverine; Phenylephrine; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Subarachnoid Hemorrhage; Time Factors; Vasodilator Agents | 1997 |
Nitric oxide can increase heart rate by stimulating the hyperpolarization-activated inward current, I(f).
Topics: Animals; Cyclic GMP; Data Interpretation, Statistical; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Ion Channels; Male; Molsidomine; Nitric Oxide; Nitroprusside; Rabbits; Sinoatrial Node; Superoxide Dismutase; Time Factors; Vasodilator Agents | 1997 |
NO-mediated vasodilation in the rat liver. Role of hepatocytes and liver endothelial cells.
Topics: Animals; Arginine; Cells, Cultured; Cytokines; Endothelium, Vascular; Guanylate Cyclase; Liver; Liver Circulation; Male; Methylene Blue; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Vasodilation | 1997 |
Effect of exogenous nitric oxide and superoxide on interleukin-8 from human polymorphonuclear leucocytes.
Topics: Cell Culture Techniques; Dose-Response Relationship, Drug; Humans; Interleukin-8; Lipopolysaccharides; Molsidomine; Neutrophil Activation; Neutrophils; Nitric Oxide; Platelet Aggregation Inhibitors; Superoxides; Triazoles | 1997 |
Oxygen modulation of guanylate cyclase-mediated retinal pericyte relaxations with 3-morpholino-sydnonimine and atrial natriuretic peptide.
Topics: Animals; Atrial Natriuretic Factor; Cattle; Cells, Cultured; Guanylate Cyclase; Hemoglobins; Methylene Blue; Molsidomine; Nitric Oxide; Oxygen; Retinal Vessels; Vasodilator Agents | 1997 |
Nitric oxide donors inhibit spontaneous depolarizations by L-type Ca2+ currents in alveolar epithelial cells.
Topics: Aminoquinolines; Animals; Calcium Channels; Calcium Channels, L-Type; Cell Line; Cyclic GMP; Enzyme Inhibitors; Epithelium; Guanylate Cyclase; Kinetics; Membrane Potentials; Microelectrodes; Molsidomine; Nitroprusside; Penicillamine; Pulmonary Alveoli; Rats; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Strontium; Time Factors | 1997 |
Heterogeneity in the vasorelaxing effect of nicorandil on dog epicardial coronary arteries: comparison with other NO donors.
Topics: Animals; Atrial Natriuretic Factor; Benzopyrans; Coronary Vessels; Cromakalim; Cyclic GMP; Dogs; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitric Oxide; Nitroglycerin; Nitroprusside; Oxyhemoglobins; Pyrroles; Vasodilator Agents | 1997 |
The oxidation of selenocysteine is involved in the inactivation of glutathione peroxidase by nitric oxide donor.
Topics: Amino Acid Sequence; Apoptosis; Glutathione Peroxidase; Molecular Sequence Data; Molsidomine; Nitrates; Nitric Oxide; Nitroprusside; Oxidation-Reduction; Selenocysteine | 1997 |
Nitric oxide induces apoptosis via triggering mitochondrial permeability transition.
Topics: Animals; Apoptosis; Cells, Cultured; Glutathione; Intracellular Membranes; Membrane Potentials; Mice; Mice, Inbred BALB C; Mitochondria, Liver; Molsidomine; Nitric Oxide; Nitroso Compounds; Penicillamine; Permeability; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Thymus Gland | 1997 |
Modulation of sensory and excitatory amino acid responses by nitric oxide donors and glutathione in the ventrobasal thalamus of the rat.
Topics: Action Potentials; Animals; Excitatory Amino Acids; Glutathione; Male; Molsidomine; N-Methylaspartate; Neurons; Nitric Oxide; Nitroprusside; Nitroso Compounds; Physical Stimulation; Rats; Rats, Wistar; S-Nitrosoglutathione; Sensation; Thalamus | 1997 |
Redox modulation of iron regulatory proteins by peroxynitrite.
Topics: Aconitate Hydratase; Animals; Cells, Cultured; Cysteine; Ferritins; Humans; Iron Regulatory Protein 1; Iron Regulatory Protein 2; Iron-Regulatory Proteins; Iron-Sulfur Proteins; Mercaptoethanol; Mice; Models, Chemical; Molsidomine; Nitrates; Nitric Oxide; Oxidation-Reduction; Point Mutation; Protein Processing, Post-Translational; Recombinant Proteins; RNA-Binding Proteins; RNA, Messenger | 1997 |
Interleukin 1beta-mediated inhibition of arginase in RINm5F cells.
Topics: Animals; Arginase; Arginine; Citrulline; Enzyme Inhibitors; Glutathione; Insulinoma; Interleukin-1; Islets of Langerhans; Molsidomine; Nitric Oxide Synthase; Nitroso Compounds; Ornithine; Rats; S-Nitrosoglutathione; Tumor Cells, Cultured | 1997 |
Influence of nitric oxide and vasoactive intestinal peptide on the spontaneous and triggered electrical and mechanical activities of the canine ileum.
Topics: Animals; Calcium Channel Blockers; Dogs; Electrophysiology; Enzyme Inhibitors; Female; Ileum; Male; Membrane Potentials; Molsidomine; Muscle Contraction; Nitric Oxide; Nitric Oxide Synthase; omega-Conotoxin GVIA; Peptides; Tetrodotoxin; Vasoactive Intestinal Peptide | 1997 |
Ursodeoxycholate inhibits induction of NOS in human intestinal epithelial cells and in vivo.
Topics: Adenocarcinoma; Animals; Cell Line, Transformed; Cell Survival; Enzyme Induction; Enzyme Repression; Humans; Intestinal Mucosa; Intestinal Neoplasms; Kinetics; Lipopolysaccharides; Mitochondria; Molsidomine; Nitrates; Nitric Oxide Synthase; Nitrites; Oxygen Consumption; Rats; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured; Ursodeoxycholic Acid | 1997 |
K(ATP) channels do not mediate vasodilation by 3-morpholinosydnonimine in goat coronary artery.
Topics: Adenosine Triphosphate; Animals; Coronary Vessels; Glyburide; Goats; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Molsidomine; Muscle, Smooth, Vascular; Pinacidil; Potassium; Potassium Channels; Tetraethylammonium; Tetraethylammonium Compounds; Vasodilation; Vasodilator Agents | 1997 |
Stimulation of neuropeptide Y release in rat pheochromocytoma cells by nitric oxide.
Topics: Animals; Blotting, Northern; Enzyme Inhibitors; Immunohistochemistry; Molsidomine; Nerve Growth Factors; Neuropeptide Y; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; PC12 Cells; Pheochromocytoma; Phosphodiesterase Inhibitors; Purinones; Radioimmunoassay; Rats; RNA; Sodium-Potassium-Exchanging ATPase | 1997 |
Suppression of neuropeptide Y1 receptor function in SK-N-MC cells by nitric oxide.
Topics: Blotting, Northern; Cyclic AMP; Molsidomine; Nitric Oxide; Nitroprusside; Penicillamine; Receptors, Neuropeptide Y; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Tumor Cells, Cultured; Vasodilator Agents | 1997 |
Peroxynitrite-induced hemolysis of human erythrocytes and its inhibition by antioxidants.
Topics: Acetylcysteine; Albumins; Amidines; Antioxidants; Azoles; Catalase; Chromans; Erythrocytes; Glutathione; Hematocrit; Hemolysis; Humans; Isoindoles; Molsidomine; Nitrates; Organoselenium Compounds; Uric Acid; Vitamin E | 1997 |
Prostaglandin E2 synthesis is differentially affected by reactive nitrogen intermediates in cultured rat microglia and RAW 264.7 cells.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Cerebral Cortex; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Isoenzymes; Lipopolysaccharides; Macrophages; Mice; Microglia; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Penicillamine; Prostaglandin-Endoperoxide Synthases; Rats; S-Nitroso-N-Acetylpenicillamine | 1997 |
Role of nitric oxide in the regulation of osteoblast metabolism.
Topics: Alkaline Phosphatase; Cell Division; Cells, Cultured; Child, Preschool; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Molsidomine; Nitric Oxide; Nitroarginine; Osteoblasts; Osteocalcin | 1997 |
Nitroxides increase the detectable amount of nitric oxide released from endothelial cells.
Topics: Animals; Calcimycin; Cattle; Cells, Cultured; Cyclic N-Oxides; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; Molecular Mimicry; Molsidomine; Nitric Oxide; Nitrogen Oxides; Spin Labels; Spin Trapping; Superoxide Dismutase; Superoxides | 1997 |
Nitric oxide attenuates platelet-activating factor priming for elastase release in human neutrophils via a cyclic guanosine monophosphate-dependent pathway.
Topics: Adult; Analysis of Variance; Cyclic GMP; Dibutyryl Cyclic GMP; Humans; In Vitro Techniques; Kinetics; Leukocyte Elastase; Models, Biological; Molsidomine; Neutrophils; Nitric Oxide; Platelet Activating Factor; Signal Transduction; Substrate Specificity | 1997 |
Nitric oxide-induced hyperpermeability of human intestinal epithelial monolayers is augmented by inhibition of the amiloride-sensitive Na(+)-H+ antiport: potential role of peroxynitrous acid.
Topics: Amiloride; Cell Membrane Permeability; Colonic Neoplasms; Deferoxamine; Humans; Intestinal Mucosa; Membrane Potentials; Molsidomine; Nitrates; Nitric Oxide; Nitrous Acid; Peroxynitrous Acid; Sodium-Hydrogen Exchangers; Superoxides; Tumor Cells, Cultured | 1997 |
Differential effects of endothelin-1 on basal and isoprenaline-enhanced Ca2+ current in guinea-pig ventricular myocytes.
Topics: Animals; Calcium Channels; Calcium Channels, L-Type; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Guinea Pigs; Heart; Heart Ventricles; Indoles; Isoenzymes; Isoproterenol; Kinetics; Maleimides; Membrane Potentials; Molsidomine; Nitric Oxide; Nystatin; Patch-Clamp Techniques; Pertussis Toxin; Protein Kinase C; Virulence Factors, Bordetella | 1997 |
The beta2 subunit inhibits stimulation of the alpha1/beta1 form of soluble guanylyl cyclase by nitric oxide. Potential relevance to regulation of blood pressure.
Topics: Animals; Blood Pressure; Blotting, Northern; Blotting, Western; Cell Line; COS Cells; Cyclic GMP; Guanylate Cyclase; Kidney; Male; Molsidomine; Muscle, Smooth; Nitric Oxide; Rats; Rats, Inbred Strains; Recombinant Fusion Proteins; RNA, Messenger; Transfection; Vasodilator Agents | 1997 |
The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide.
Topics: Animals; Brain; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Hydrogen Sulfide; Ileum; In Vitro Techniques; Mammals; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitroprusside; Transcription, Genetic | 1997 |
Centrally applied nitric oxide donors inhibit vagally evoked rat gastric acid secretion: involvement of sympathetic outflow.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Gastric Acid; Indomethacin; Injections, Intraventricular; Male; Molsidomine; Nitric Oxide; Nitroprusside; Phentolamine; Rats; Rats, Wistar; Splanchnic Nerves; Vagus Nerve | 1997 |
Variations of segmental endothelium-dependent and endothelium-independent vasomotor tone after cardiac transplantation (qualitative changes in endothelial function).
Topics: Acetylcholine; Coronary Circulation; Coronary Vessels; Endothelium, Vascular; Female; Heart Transplantation; Hemodynamics; Humans; Male; Middle Aged; Molsidomine; Nitroglycerin; Vasoconstriction; Vasodilation; Vasodilator Agents | 1997 |
Hypoxia compared with normoxia alters the effects of nitric oxide in ischemia-reperfusion lung injury.
Topics: Animals; Arginine; Blood Pressure; Hypoxia; In Vitro Techniques; Lung; Male; Microcirculation; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pulmonary Artery; Pulmonary Circulation; Rabbits; Reperfusion Injury; Stereoisomerism; Superoxide Dismutase; Vascular Resistance | 1997 |
The antiadhesive and antithrombotic effects of the nitric oxide donor SIN-1 are combined with a decreased vasoconstriction in a porcine model of balloon angioplasty.
Topics: Angioplasty, Balloon; Animals; Blood Coagulation; Carotid Arteries; Carotid Artery Injuries; Cell Adhesion; Female; Fibrinolytic Agents; In Vitro Techniques; Male; Molsidomine; Neutrophils; Nitric Oxide; Perfusion; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Swine; Vasoconstriction; Vasodilator Agents | 1997 |
Dysfunction of nitric oxide induces protein kinase C activation resulting in vasospasm after subarachnoid hemorrhage.
Topics: Animals; Basilar Artery; Cyclic GMP; Dogs; Enzyme Activation; Enzyme Inhibitors; Female; Immunoenzyme Techniques; Ischemic Attack, Transient; Male; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Protein Kinase C; Reference Values; Subarachnoid Hemorrhage | 1997 |
Delayed coronary endothelial protection 24 hours after preconditioning: role of free radicals.
Topics: Acetylcholine; Animals; Coronary Vessels; Endothelium, Vascular; Free Radical Scavengers; In Vitro Techniques; Ischemic Preconditioning; Male; Molsidomine; Muscle Contraction; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Reactive Oxygen Species; Serotonin; Time Factors; Tiopronin; Vasodilator Agents | 1997 |
Effects of nitric oxide on blood flow distribution and O2 extraction capabilities during endotoxic shock.
Topics: Animals; Blood Pressure; Cardiac Output; Cardiac Tamponade; Dogs; Endotoxins; Enzyme Inhibitors; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxygen Consumption; Regional Blood Flow; Shock, Septic; Sodium-Potassium-Exchanging ATPase; Vascular Resistance | 1997 |
The effects of L-arginine on neointimal formation and vascular function following balloon injury in heritable hyperlipidaemic rabbits.
Topics: Angioplasty, Balloon; Animals; Arginine; Calcimycin; Carbachol; Endothelium, Vascular; Hyperlipidemias; In Vitro Techniques; Male; Molsidomine; Muscle, Smooth, Vascular; Platelet Aggregation; Platelet Aggregation Inhibitors; Potassium Chloride; Rabbits; Serotonin; Tunica Intima; Vasoconstrictor Agents; Vasodilator Agents | 1997 |
Disrupted [Ca2+]i homeostasis contributes to the toxicity of nitric oxide in cultured hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Benzamides; Calcium; Cells, Cultured; Cysteine; Cysteine Proteinase Inhibitors; Dipeptides; Embryo, Mammalian; Enzyme Inhibitors; Free Radical Scavengers; Hemoglobins; Hippocampus; Homeostasis; Molsidomine; Neurons; Nitric Oxide; Penicillamine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; S-Nitrosothiols; Superoxide Dismutase | 1997 |
Nitric oxide does not modulate kainate receptor binding in human brain.
Topics: Brain; Cysteine; Female; Humans; Male; Middle Aged; Molsidomine; Nitric Oxide; Penicillamine; Receptors, Kainic Acid; S-Nitroso-N-Acetylpenicillamine; S-Nitrosothiols | 1997 |
Differential induction of c-fos, c-jun, and apoptosis in lung epithelial cells exposed to ROS or RNS.
Topics: Animals; Apoptosis; Cell Line; Epithelial Cells; Genes, fos; Genes, jun; Hydrogen Peroxide; Lung; Molsidomine; Nitrates; Nitric Oxide; Penicillamine; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Reactive Oxygen Species; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Spermine; Transcription, Genetic | 1997 |
Active site modification of aldose reductase by nitric oxide donors.
Topics: Aldehyde Reductase; Binding Sites; Borohydrides; Catalysis; Diabetes Complications; Diabetes Mellitus; Dithiothreitol; Enzyme Inhibitors; Glyceraldehyde; Humans; Kinetics; Molsidomine; Mutagenesis, Site-Directed; NADP; Nitric Oxide; Nitroprusside; Penicillamine; Placenta; Recombinant Proteins; S-Nitroso-N-Acetylpenicillamine | 1997 |
Nitric oxide as a regulator of prostacyclin synthesis in cultured rat heart endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Female; Guanylate Cyclase; Male; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Triazoles; Vasodilator Agents | 1997 |
Nitric oxide production during Vibrio cholerae infection.
Topics: Adult; Aged; Animals; Cholera; Cholera Toxin; Diarrhea; Dihydrolipoamide Dehydrogenase; Enzyme Inhibitors; Female; Humans; Ileum; Intestine, Small; Male; Microbial Sensitivity Tests; Middle Aged; Molsidomine; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Peru; Rabbits; Reference Values; Time Factors; United States; Vibrio cholerae | 1997 |
YVAD protect post-natal retinal ganglion cells against axotomy-induced but not free radical-induced axonal degeneration in vitro.
Topics: Animals; Apoptosis; Axons; Free Radicals; Mice; Molsidomine; Nerve Degeneration; Nerve Regeneration; Neurites; Neuroprotective Agents; Oligopeptides; Organ Culture Techniques; Rats; Retinal Ganglion Cells; Serine Proteinase Inhibitors | 1997 |
Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation.
Topics: Animals; Apoptosis; Borates; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Dactinomycin; Dithiothreitol; Humans; Kinetics; Liver; Male; Mercuric Chloride; Molsidomine; Nitric Oxide; Nitroso Compounds; Penicillamine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Tumor Necrosis Factor-alpha | 1997 |
Lack of effect of two nitric oxide donors on hydrogen peroxide-induced endothelial barrier dysfunction.
Topics: Animals; Cattle; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Endothelium, Vascular; Hydrogen Peroxide; Molsidomine; Nitric Oxide; Penicillamine; Pulmonary Artery; S-Nitroso-N-Acetylpenicillamine | 1997 |
Effect of anti-oxidants on the degradation of SIN-1.
Topics: Antioxidants; Antipyrine; Biotransformation; Cytochrome c Group; Hydrogen Peroxide; Kinetics; Molsidomine; Nitrates; Oxidation-Reduction; Superoxide Dismutase | 1997 |
Neutrophil transmigration: modulation by pentoxifylline and nitric oxide.
Topics: Chemotaxis, Leukocyte; Endothelium, Vascular; Fibronectins; Humans; In Vitro Techniques; Microspheres; Molsidomine; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentoxifylline | 1997 |
Bioeffects of a nitric oxide donor in a human preosteoclastic cell line.
Topics: Acid Phosphatase; Adult; Animals; Cell Adhesion; Cell Line; Citrulline; Female; Filaggrin Proteins; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-6; Molsidomine; Nitric Oxide; Osteoclasts; Rats; Tetradecanoylphorbol Acetate | 1997 |
Determination of nitric oxide generation in mammalian neurons using dichlorofluorescin diacetate and flow cytometry.
Topics: Animals; Enzyme Inhibitors; Flow Cytometry; Fluoresceins; Kainic Acid; Molsidomine; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Sprague-Dawley | 1997 |
Peroxynitrite-induced toxicity in cultured astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Cell Death; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Glutathione; Hydrogen-Ion Concentration; Kinetics; L-Lactate Dehydrogenase; Molsidomine; Nitrates; Nitric Oxide; Nitroso Compounds; Oxidants; Rats; S-Nitrosoglutathione; Superoxides | 1997 |
Attenuation of contrast material-induced renal artery vasoconstriction by nitric oxide donors.
Topics: Animals; Contrast Media; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vascular; Enzyme Inhibitors; Humans; Molsidomine; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Phenylephrine; Rabbits; Renal Artery; Tissue Donors; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 1997 |
Hepatocyte apoptosis and cytosolic calcium dynamics in ischemic injury.
Topics: Animals; Apoptosis; Cells, Cultured; DNA Fragmentation; Ischemia; Liver; Mice; Mice, Inbred BALB C; Molsidomine; Reperfusion Injury; Vasodilator Agents | 1997 |
Effects of nitric oxide on chemotaxis and endotoxin-induced interleukin-8 production in human neutrophils.
Topics: Acetylcysteine; Cells, Cultured; Chemotaxis; Complement C5a; Cyclic GMP; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Ferricyanides; Glutathione; Humans; Interleukin-8; Leukotriene B4; Lipopolysaccharides; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Nitroso Compounds; omega-N-Methylarginine; RNA, Messenger; S-Nitrosoglutathione; Up-Regulation | 1998 |
Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation.
Topics: Animals; Calcium; Cyclic GMP; Cysteine; Dithiothreitol; Dogs; Electric Conductivity; Ethylmaleimide; Glutathione; Liposomes; Mercaptoethanol; Molsidomine; Myocardium; Nitric Oxide; Nitrosation; Nitroso Compounds; Oxidation-Reduction; Proteolipids; Ryanodine Receptor Calcium Release Channel; S-Nitrosoglutathione; S-Nitrosothiols; Sulfhydryl Compounds | 1998 |
Possible role of nitric oxide in IgE-mediated allergic cutaneous reaction in mice.
Topics: Animals; Arginine; Dinitrofluorobenzene; Dinitrophenols; Edema; Female; Immunization, Passive; Immunoglobulin E; Interleukin-1; Mice; Mice, Inbred BALB C; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Tumor Necrosis Factor-alpha; Vasculitis, Leukocytoclastic, Cutaneous | 1998 |
Nitric oxide donation and nitrite assays in the presence of thiols and albumin as determined by Griess' and Werringloer's methods.
Topics: Amino Acids; Cysteine; Glutathione; Molsidomine; Nitric Oxide; Nitrites; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Serum Albumin, Bovine; Sodium Nitrite; Sulfhydryl Compounds | 1997 |
The nitric oxide donor SIN-1 protects endothelial cells from tumor necrosis factor-alpha-mediated cytotoxicity: possible role for cyclic GMP and heme oxygenase.
Topics: Acetonitriles; Animals; Cattle; Cells, Cultured; Cyclic GMP; Drug Interactions; Endothelium, Vascular; Heme Oxygenase (Decyclizing); Molsidomine; Morpholines; Nitric Oxide; Reactive Oxygen Species; Tumor Necrosis Factor-alpha; Vasodilator Agents | 1997 |
Ferritin may mediate SIN-1-induced protection against oxidative stress.
Topics: Animals; Antioxidants; Cell Survival; Endothelium, Vascular; Ferritins; Gene Expression Regulation; Hydrogen Peroxide; Molsidomine; Oxidative Stress; RNA, Messenger; Swine | 1997 |
Nitric oxide and peroxynitrite affect differently acetylcholine release, choline acetyltransferase activity, synthesis, and compartmentation of newly formed acetylcholine in Torpedo marmorata synaptosomes.
Topics: Acetylcholine; Animals; Calcimycin; Cell Compartmentation; Choline O-Acetyltransferase; Electric Organ; Enzyme Inhibitors; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Potassium Chloride; Synaptosomes; Torpedo | 1997 |
In vitro studies of interactions of NO. donor drugs with superoxide and hydroxyl radicals.
Topics: Free Radicals; Hydrogen-Ion Concentration; Hydroxyl Radical; Molsidomine; Nitric Oxide; Nitroprusside; Oxidation-Reduction; Sodium Nitrite; Superoxides | 1997 |
Central application of a nitric oxide donor activates heat defense in the rabbit.
Topics: Animals; Blood Pressure; Body Temperature; Body Temperature Regulation; Brain; Chinchilla; Ear; Female; Heart Rate; Hot Temperature; Hybridization, Genetic; Injections, Intraventricular; Molsidomine; Nitric Oxide; Oxygen Consumption; Rabbits; Respiration; Skin Temperature; Water Loss, Insensible | 1997 |
Nitric oxide and cyclic nucleotides participate in the relaxation of diclofenac on rat uterine smooth muscle.
Topics: Adenylyl Cyclases; Animals; Cyclic GMP; Cyclooxygenase Inhibitors; Diclofenac; Drug Interactions; Enzyme Inhibitors; Female; GTP-Binding Proteins; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Nucleotides, Cyclic; omega-N-Methylarginine; Oxadiazoles; Pertussis Toxin; Quinoxalines; Rats; Rats, Wistar; Sensitivity and Specificity; Sulfonamides; Uterine Contraction; Uterus; Vanadates; Vasodilator Agents; Virulence Factors, Bordetella | 1998 |
Nitric oxide and peroxynitrite-mediated pulmonary cell death.
Topics: Acetylcysteine; Animals; Cattle; Cell Death; Cells, Cultured; Endothelium, Vascular; Epithelial Cells; Kinetics; Lung; Male; Molsidomine; Nitrates; Nitric Oxide; Nitrogen Oxides; Oxidants; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Spermine | 1998 |
The effects of nitric oxide and peroxynitrite on interleukin-8 and elastase from lipopolysaccharide-stimulated whole blood.
Topics: Free Radical Scavengers; Humans; In Vitro Techniques; Interleukin-8; Leukocyte Elastase; Lipopolysaccharides; Male; Molsidomine; Nitrates; Nitric Oxide; Triazoles | 1998 |
Peroxynitrite aggravates myocardial reperfusion injury in the isolated perfused rat heart.
Topics: Animals; Creatine Kinase; Glutathione; L-Lactate Dehydrogenase; Male; Molsidomine; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Nitrates; Perfusion; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Vasodilator Agents | 1997 |
Subarachnoid hemorrhage and the role of potassium channels in relaxations of canine basilar artery to nitrovasodilators.
Topics: 4-Aminopyridine; Animals; Basilar Artery; Charybdotoxin; Cyclic GMP; Dogs; Female; Humans; Male; Molsidomine; Nitroprusside; Potassium Channels; Subarachnoid Hemorrhage; Uridine Triphosphate; Vasodilation; Vasodilator Agents | 1998 |
Nitric oxide donor-induced apoptosis in smooth muscle cells is modulated by protein kinase C and protein kinase A.
Topics: Animals; Aorta; Apoptosis; Cyclic AMP-Dependent Protein Kinases; Membrane Proteins; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Penicillamine; Protein Kinase C; Rabbits; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents | 1997 |
Suppressed production of nitric oxide as a cause of irregular constriction of gastric venules induced by thermal injury in rats.
Topics: Animals; Burns; Gastric Mucosa; Male; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Time Factors; Vasoconstriction; Vasodilator Agents; Venules | 1997 |
Role of nitric oxide synthase inhibition in the acute hypertensive response to intracerebroventricular cadmium.
Topics: Animals; Arginine; Blood Pressure; Brain Chemistry; Cadmium; Calcium Chloride; Citrulline; Enzyme Inhibitors; Heart Rate; Hypertension; Injections, Intraventricular; Male; Molsidomine; Nitric Oxide Synthase; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents | 1998 |
The NO/cGMP pathway and the development of neural networks in postembryonic lobsters.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Central Nervous System; Cyclic GMP; Female; Ganglia, Invertebrate; Larva; Molsidomine; Nephropidae; Nerve Net; Nerve Tissue Proteins; Neuronal Plasticity; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Penicillamine; Signal Transduction; Smell | 1998 |
Nitrergic and cholinergic innervation of the rat lower urinary tract after pelvic ganglionectomy.
Topics: Acetylcholine; Animals; Carbachol; Cyclic GMP; Electric Stimulation; Female; Ganglia; Ganglionectomy; Immunohistochemistry; Molsidomine; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Parasympathomimetics; Rats; Rats, Sprague-Dawley; Urethra; Urinary Bladder; Urinary Tract | 1998 |
Effect of nitric oxide on the adhesion of human melanocytes to extracellular matrix components.
Topics: Cell Adhesion; Cell Culture Techniques; Cell Division; Extracellular Matrix; Fibronectins; Flow Cytometry; Glutathione; Humans; Immunoenzyme Techniques; Melanocytes; Molsidomine; Nitric Oxide; Nitrites; Nitroso Compounds; S-Nitrosoglutathione | 1997 |
Possible involvement of nitric oxide-cGMP pathway in the negative chronotropic effect of CD-832, a novel dihydropyridine derivative.
Topics: Animals; Calcium Channel Blockers; Cyclic GMP; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Molsidomine; Niacinamide; Nifedipine; Nitric Oxide | 1998 |
Poly(ADP-ribose) synthetase activation mediates increased permeability induced by peroxynitrite in Caco-2BBe cells.
Topics: Adenosine Triphosphate; Caco-2 Cells; DNA Damage; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Molsidomine; Nitrates; Nitric Oxide; Penicillamine; Permeability; Poly(ADP-ribose) Polymerases; S-Nitroso-N-Acetylpenicillamine | 1998 |
Nitric oxide superoxide and peroxynitrite modulate osteoclast activity.
Topics: Animals; Animals, Newborn; Bone Resorption; Calcium; Catalase; Cells, Cultured; Cyclic GMP; Enzyme Activation; Hydrogen Peroxide; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Osteoclasts; Rats; Rats, Sprague-Dawley; Superoxides; Thionucleotides | 1998 |
Exogenous nitric oxide inhibits mesangial cell adhesion to extracellular matrix components.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Collagen; Cyclic GMP; Cytoskeleton; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glomerular Mesangium; Glutathione; Molsidomine; Nitric Oxide; Nitroprusside; Nitroso Compounds; Penicillamine; Protein-Tyrosine Kinases; Rats; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Signal Transduction | 1998 |
Up-regulation of base excision repair correlates with enhanced protection against a DNA damaging agent in mouse cell lines.
Topics: Animals; Cell Line; DNA Damage; DNA Polymerase beta; DNA Repair; Enzyme Inhibitors; Escherichia coli; Fibroblasts; Hydrogen Peroxide; Kinetics; Lipopolysaccharides; Methyl Methanesulfonate; Mice; Molsidomine; Monocytes; Oxidative Stress; Xanthine; Xanthine Dehydrogenase | 1998 |
Morin hydrate: a better protector than purpurogallin of corneal endothelial cell damage induced by xanthine oxidase and SIN-1.
Topics: Animals; Antioxidants; Benzocycloheptenes; Cell Survival; Cells, Cultured; Chromans; Cytoprotection; Endothelium, Corneal; Flavonoids; Free Radical Scavengers; Free Radicals; Hypoxanthine; Molsidomine; Rabbits; Xanthine Oxidase | 1998 |
Nitric oxide donor NOR 3 inhibits ketogenesis from oleate in isolated rat hepatocytes by a cyclic GMP-independent mechanism.
Topics: Adenosine Triphosphate; Animals; Benzoates; Calcium; Cells, Cultured; Cyclic GMP; Imidazoles; Lactic Acid; Liver; Male; Molsidomine; Nitric Oxide; Nitro Compounds; Oleic Acid; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Sodium Nitrite; Vasodilator Agents | 1998 |
Mechanisms of relaxations of bovine isolated bronchioles by the nitric oxide donor, GEA 3175.
Topics: Albuterol; Aminoquinolines; Animals; Apamin; Bronchi; Bronchodilator Agents; Cattle; Charybdotoxin; Female; Glyburide; Male; Molsidomine; Muscle Relaxation; Nitric Oxide; Oxyhemoglobins; Penicillamine; Peptides; Receptors, Adrenergic, beta-2; Superoxide Dismutase; Triazoles | 1998 |
Epidermal growth factor protects neuronal cells in vivo and in vitro against transient forebrain ischemia- and free radical-induced injuries.
Topics: Animals; Apoptosis; Avoidance Learning; Brain Ischemia; Cells, Cultured; DNA Fragmentation; Epidermal Growth Factor; Ferrous Compounds; Free Radicals; Gerbillinae; Hippocampus; Lipid Peroxidation; Male; Molsidomine; Neurites; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Prosencephalon; Reaction Time; Synapses | 1998 |
Autocrine regulation of endothelial exocytosis: von Willebrand factor release is induced by prostacyclin in cultured endothelial cells.
Topics: Adenosine; Cells, Cultured; Colforsin; Cyclic AMP; Endothelium, Vascular; Epoprostenol; Exocytosis; Humans; Iloprost; Molsidomine; Nitric Oxide; Nitroprusside; Thrombin; von Willebrand Factor | 1998 |
Nitric oxide rather than superoxide or peroxynitrite inhibits insulin secretion and causes DNA damage in HIT-T15 cells.
Topics: Animals; Cell Line; Cell Nucleus; Cricetinae; Glutathione; Insulin; Insulin Secretion; Islets of Langerhans; Mesocricetus; Molsidomine; Nitric Oxide; Nitroso Compounds; S-Nitrosoglutathione; Superoxide Dismutase; Superoxides | 1997 |
Inhibitory effect of inducible type nitric oxide synthase on oxidative modification of low density lipoprotein by vascular smooth muscle cells.
Topics: Animals; Cells, Cultured; Copper; Electrophoresis, Agar Gel; Enzyme Induction; Enzyme Inhibitors; Humans; Kinetics; Lipoproteins, LDL; Mice; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Penicillamine; Rats; S-Nitroso-N-Acetylpenicillamine; Sodium-Potassium-Exchanging ATPase | 1998 |
Increased sensitivity of fibroblasts from amyotrophic lateral sclerosis patients to oxidative stress.
Topics: Amyotrophic Lateral Sclerosis; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Fibroblasts; Humans; Hydrogen Peroxide; Kinetics; Molsidomine; Oxidative Stress; Point Mutation; Reference Values; Skin; Superoxide Dismutase | 1998 |
Peroxynitrite increases the degradation of aconitase and other cellular proteins by proteasome.
Topics: Aconitate Hydratase; Cysteine Endopeptidases; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Hydrolysis; Molsidomine; Multienzyme Complexes; Nitrates; Oxidative Stress; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 1998 |
The critical role of Hepes in SIN-1 cytotoxicity, peroxynitrite versus hydrogen peroxide.
Topics: Animals; Buffers; Catalase; Cell Death; Cell Line; Fibroblasts; HEPES; Hydrogen Peroxide; Kinetics; L-Lactate Dehydrogenase; Mice; Molsidomine; Nitrates | 1998 |
Control of growth and differentiation of normal human epithelial cells through the manipulation of reactive nitrogen species.
Topics: Catalase; Cell Differentiation; Cell Division; Cyclic N-Oxides; Fluorescent Antibody Technique; Free Radical Scavengers; Humans; Hydrazines; Imidazoles; Keratinocytes; Molsidomine; Nitrates; Nitric Oxide; Superoxide Dismutase; Thymidine | 1998 |
Relations of platelet Ca2+ handling and membrane microviscosity to vascular tone and restenosis after angioplasty in human coronary artery.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Blood Platelets; Calcium; Coronary Vessels; Disease Susceptibility; Female; Fluorescent Dyes; Humans; Lipids; Male; Membrane Fluidity; Middle Aged; Molsidomine; Nitric Oxide; Recurrence; Risk Factors; Thrombin; Vascular Resistance; Vasodilation | 1998 |
Evidence that different mechanisms underlie smooth muscle relaxation to nitric oxide and nitric oxide donors in the rabbit isolated carotid artery.
Topics: Acetylcholine; Animals; Apamin; Calcimycin; Carotid Arteries; Cell Membrane; Cyclic GMP; Glyburide; In Vitro Techniques; Membrane Potentials; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Penicillamine; Peptides; Potassium Channel Blockers; Rabbits | 1998 |
Hydrogen peroxide formation by reaction of peroxynitrite with HEPES and related tertiary amines. Implications for a general mechanism.
Topics: Amines; Animals; Bicarbonates; Carbon Dioxide; Cattle; HEPES; Hydrogen Peroxide; Molsidomine; Nitrates; Oxygen; Superoxide Dismutase; Tryptophan | 1998 |
Nitric oxide donors protect cultured rat astrocytes from 1-methyl-4-phenylpyridinium-induced toxicity.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Astrocytes; Cells, Cultured; Free Radicals; Molsidomine; Neuroprotective Agents; Nitric Oxide; Nitroprusside; Penicillamine; Rats; Rats, Sprague-Dawley; Rotenone | 1998 |
Exogenous nitric oxide reduces oxygen consumption of isolated ventricular myocytes less than other forms of guanylate cyclase stimulation.
Topics: Animals; Cells, Cultured; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Heart; Heart Ventricles; Molsidomine; Myocardium; Nitric Oxide; Oxygen Consumption; Rabbits | 1998 |
(-)-Deprenyl protects human dopaminergic neuroblastoma SH-SY5Y cells from apoptosis induced by peroxynitrite and nitric oxide.
Topics: Antiparkinson Agents; Apoptosis; DNA Damage; Dopamine; Electrophoresis, Agar Gel; Humans; Molsidomine; Monoamine Oxidase Inhibitors; Neuroblastoma; Nitrates; Nitric Oxide; Oxidants; Pyridines; Selegiline; Tumor Cells, Cultured | 1998 |
Rapid and irreversible inhibition of creatine kinase by peroxynitrite.
Topics: Acetonitriles; Animals; Creatine Kinase; Enzyme Activation; Enzyme Inhibitors; Enzyme Reactivators; Glutathione; Glutathione Disulfide; Kinetics; Molsidomine; Morpholines; Nitrates; Nitric Oxide; Oxidants; Rabbits; Sulfhydryl Compounds; Superoxides | 1998 |
Peroxynitrite inhibits amiloride-sensitive Na+ currents in Xenopus oocytes expressing alpha beta gamma-rENaC.
Topics: Amiloride; Animals; Calcium; Electric Conductivity; Epithelial Sodium Channels; Female; Molsidomine; Nitrates; Oocytes; Oxidants; Rats; Sodium; Sodium Channels; Tetranitromethane; Xenopus laevis | 1998 |
Radical releasing properties of nitric oxide donors GEA 3162, SIN-1 and S-nitroso-N-acetylpenicillamine.
Topics: Molsidomine; Nitric Oxide; Oxygen; Penicillamine; Superoxides; Triazoles; Tyrosine | 1998 |
Modulation of angiotensin-converting enzyme by nitric oxide.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Carotid Arteries; Diethylamines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Male; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Oligopeptides; Oxadiazoles; Peptidyl-Dipeptidase A; Quinoxalines; Rabbits; Rats; Rats, Sprague-Dawley | 1998 |
Involvement of intracellular Ca2+ stores in inhibitory effects of NO donor SIN-1 and cGMP.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Animals; Apamin; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Carbachol; Charybdotoxin; Cyclic GMP; Egtazic Acid; Glyburide; Ileum; In Vitro Techniques; Indoles; Kinetics; Male; Molsidomine; Muscle Contraction; Muscle, Smooth; Peptides; Potassium Channels; Rats; Rats, Wistar; Tetraethylammonium; Tetrodotoxin; Thionucleotides | 1998 |
Relaxing effects of NO donors on guinea pig trachea in vitro are mediated by calcium-sensitive potassium channels.
Topics: 4-Aminopyridine; Animals; Calcium; Charybdotoxin; Female; Glyburide; Guinea Pigs; Male; Molsidomine; Nitric Oxide; Peptides; Potassium Channels; Trachea; Triazoles | 1998 |
Effects of nitric oxide on adenylyl cyclase stimulation in N18TG2 neuroblastoma cells.
Topics: Adenylyl Cyclase Inhibitors; Animals; Calmodulin; Colforsin; Cyclic AMP; Cyclic GMP; GTP-Binding Protein alpha Subunits, Gi-Go; Mice; Molsidomine; Neuroblastoma; Nitric Oxide; Tumor Cells, Cultured | 1998 |
Activation of soluble guanylyl cyclase by the nitrovasodilator 3-morpholinosydnonimine involves formation of S-nitrosoglutathione.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Enzyme Activation; Glutathione; Guanylate Cyclase; Molsidomine; Nitric Oxide; Nitroso Compounds; S-Nitrosoglutathione; Superoxides; Vasodilator Agents | 1998 |
Nitric oxide generators produce accumulation of chelatable zinc in hippocampal neuronal perikarya.
Topics: Aminoquinolines; Animals; Chelating Agents; Fluorescent Dyes; Hippocampus; Male; Molsidomine; Neurons; Nitric Oxide; Nitrogen Oxides; Nitroprusside; Rats; Rats, Wistar; Spermine; Staining and Labeling; Tosyl Compounds; Zinc | 1998 |
Methylene blue inhibits stimulatory effect of sodium nitroprusside but not of 3-morpholino sydnonimine on prolactin secretion in freely moving male rats.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Injections, Intraventricular; Male; Methylene Blue; Molsidomine; Nitroprusside; Prolactin; Rats; Rats, Sprague-Dawley | 1998 |
IFN-gamma inhibits AP-1 binding activity in human brain-derived cells through a nitric oxide dependent mechanism.
Topics: Brain; Cell Nucleus; Cells, Cultured; Enzyme Inhibitors; Humans; Interferon-gamma; Molsidomine; Nitric Oxide; omega-N-Methylarginine; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Transcription Factor AP-1 | 1998 |
[Erectile response to intracavernous injection of linsidomine in 38 impotent patients. Comparison with prostaglandin E1].
Topics: Adult; Aged; Alprostadil; Data Interpretation, Statistical; Erectile Dysfunction; Humans; Impotence, Vasculogenic; Injections; Male; Middle Aged; Molsidomine; Penis; Time Factors; Vasodilator Agents | 1998 |
Interactions between endothelium-derived relaxing factors in the rat hepatic artery: focus on regulation of EDHF.
Topics: Animals; Apamin; Biological Factors; Charybdotoxin; Endothelium, Vascular; Hepatic Artery; Iloprost; In Vitro Techniques; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Potassium Channel Blockers; Potassium Chloride; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1998 |
Polarographic detection of nitric oxide released from cardiovascular compounds in aqueous solutions.
Topics: Cardiovascular Agents; Molsidomine; Nicorandil; Nitric Oxide; Nitroglycerin; Nitroprusside; Polarography; Solutions; Water | 1998 |
Monocyte inducible nitric oxide synthase in multiple sclerosis: regulatory role of nitric oxide.
Topics: Amino Acid Sequence; Flow Cytometry; HLA-DR Antigens; Humans; Immunohistochemistry; Immunophenotyping; Molecular Sequence Data; Molsidomine; Monocytes; Multiple Sclerosis; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oligopeptides; omega-N-Methylarginine; Receptors, IgG; RNA, Messenger | 1997 |
Inhibition of clotting factor XIII activity by nitric oxide.
Topics: Dose-Response Relationship, Drug; Enzyme Inhibitors; Factor XIII; Glutathione; Humans; Molsidomine; Nitric Oxide; Nitroso Compounds; Penicillamine; Platelet Aggregation Inhibitors; S-Nitrosoglutathione; Spermine | 1998 |
Role of nonselective cation channels as Ca2+ entry pathway in endothelin-1-induced contraction and their suppression by nitric oxide.
Topics: Animals; Aorta; Calcium; Calcium Channel Blockers; Endothelin-1; Imidazoles; In Vitro Techniques; Ion Channels; Ion Transport; Male; Molsidomine; Muscle Contraction; Muscle Relaxation; Nifedipine; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Rats; Rats, Wistar | 1998 |
Effects of nitric oxide modulation on tumour blood flow and microvascular permeability in C6 glioma.
Topics: Animals; Autoradiography; Brain Neoplasms; Capillary Permeability; Cerebrovascular Circulation; Enzyme Inhibitors; Glioma; Molsidomine; Neoplasm Transplantation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats | 1998 |
Thromboxane A2 is involved in the nitric oxide-induced central activation of adrenomedullary outflow in rats.
Topics: Animals; Benzoates; Cyclooxygenase Inhibitors; Epinephrine; Imidazoles; Indomethacin; Injections, Intraventricular; Male; Medulla Oblongata; Molsidomine; Nitric Oxide; Norepinephrine; Rats; Rats, Wistar; Receptors, Thromboxane; Superoxide Dismutase; Thromboxane A2; Thromboxane-A Synthase | 1998 |
Endothelial damage due to ischemia and reperfusion is prevented with SIN-1.
Topics: Animals; Endothelium, Vascular; Male; Molsidomine; Rabbits; Reperfusion Injury; Vasodilation; Vasodilator Agents | 1998 |
Role of sarcoplasmic reticulum in the myorelaxant activity of nitric oxide donors in guinea pig gastric fundus.
Topics: Acetylcholine; Animals; Calcimycin; Calcium; Enzyme Inhibitors; Gastric Fundus; Guinea Pigs; Indoles; Ionophores; Male; Membrane Potentials; Molsidomine; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Nitric Oxide Donors; Nitroprusside; Potassium Channel Blockers; Sarcoplasmic Reticulum; Sodium-Calcium Exchanger; Thapsigargin; Vasodilator Agents | 1998 |
Effect of K+ channel blocking drugs and nitric oxide synthase inhibition on the response to hypoxia in rat pulmonary artery rings.
Topics: Animals; Cell Hypoxia; Endothelium, Vascular; Enzyme Inhibitors; Hypoxia; In Vitro Techniques; Male; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxygen; Potassium Channel Blockers; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilation | 1998 |
cGMP inhibits IP3-induced Ca2+ release in intact rat megakaryocytes via cGMP- and cAMP-dependent protein kinases.
Topics: Animals; Bone Marrow Cells; Calcium; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; Megakaryocytes; Models, Biological; Molsidomine; Nitric Oxide Donors; Nitroprusside; Photolysis; Rats; Rats, Wistar; Second Messenger Systems; Thionucleotides | 1998 |
Direct activation of K(Ca) channel in airway smooth muscle by nitric oxide: involvement of a nitrothiosylation mechanism?
Topics: Animals; Bronchi; Calcium; Charybdotoxin; Cyclic GMP; Dithiothreitol; Ethylmaleimide; Glutathione; Humans; Hydrazines; Lipid Bilayers; Male; Molsidomine; Muscle, Smooth; Nitric Oxide; Potassium Channels; Rats; Rats, Sprague-Dawley | 1998 |
Inhibitory effects of nitric oxide donors on nitric oxide synthesis in rat gastric myenteric plexus.
Topics: Animals; Calcium Channels; Citrulline; Cyclic GMP; Dose-Response Relationship, Drug; Gastric Mucosa; Male; Molsidomine; Muscle Relaxation; Myenteric Plexus; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Rats; Rats, Sprague-Dawley; Stomach; Vasoactive Intestinal Peptide | 1998 |
Peroxynitrite modulates MnSOD gene expression in lung epithelial cells.
Topics: Animals; Blotting, Northern; Cell Line; Epithelial Cells; Gene Expression; Humans; Hydrogen Peroxide; Luciferases; Lung; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Rats; Recombinant Fusion Proteins; RNA, Messenger; Superoxide Dismutase | 1998 |
Treatment of Paracoccidioides brasiliensis-infected mice with a nitric oxide inhibitor prevents the failure of cell-mediated immune response.
Topics: Animals; Cell-Free System; Drug Administration Schedule; Immunity, Cellular; Injections, Intraperitoneal; Lung; Lung Diseases, Parasitic; Lymphocyte Activation; Macrophages, Alveolar; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitroarginine; Paracoccidioides; Paracoccidioidomycosis; Penicillamine; Spleen; Tumor Necrosis Factor-alpha | 1998 |
Effect of cross-linked hemoglobin transfusion on endothelial-dependent dilation in cat pial arterioles.
Topics: Acetylcholine; Animals; Arterioles; Aspirin; Cats; Cross-Linking Reagents; Decanoic Acids; Endothelium, Vascular; Hemoglobins; Humans; Male; Molsidomine; Nitric Oxide Donors; Nitroarginine; Perfusion; Pia Mater; Salicylates; Serum Albumin; Vasodilation | 1998 |
Angiotensin II-induced hypertrophy of adult rat cardiomyocytes is blocked by nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Angiotensin II; Animals; Bradykinin; Cardiomegaly; Cells, Cultured; Coculture Techniques; Cyclic GMP; Endothelium, Vascular; Heart; Iloprost; Indomethacin; Male; Molsidomine; Myocardium; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; omega-N-Methylarginine; Phenylalanine; Protein Biosynthesis; Rats; Rats, Sprague-Dawley | 1998 |
Protein kinase G expression in the small intestine and functional importance for smooth muscle relaxation.
Topics: Alkaloids; Animals; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Guinea Pigs; Indoles; Intestinal Mucosa; Intestine, Small; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth; Myenteric Plexus; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Polymerase Chain Reaction; Pyrroles; Rats; Rats, Wistar; Thionucleotides | 1998 |
Lack of tyrosine nitration by peroxynitrite generated at physiological pH.
Topics: Carbon Dioxide; Free Radicals; Hydrogen-Ion Concentration; Models, Chemical; Molsidomine; Nitrates; Nitrogen Oxides; Spermine; Tyrosine; Xanthine Oxidase | 1998 |
Nitric oxide inhibition of the rat olfactory cyclic nucleotide-gated cation channel.
Topics: Animals; Cyclic AMP; Cyclic Nucleotide-Gated Cation Channels; Cysteine; Dithionitrobenzoic Acid; Dithiothreitol; Ethylmaleimide; Ion Channel Gating; Ion Channels; Molsidomine; Nitric Oxide Donors; Nitroso Compounds; Olfactory Receptor Neurons; Rats; S-Nitrosothiols; Sulfhydryl Reagents | 1998 |
Potentiation of N-methyl-D-aspartate-mediated neurotoxicity by immunostimulated murine microglia.
Topics: Animals; Apoptosis; Catalase; Cerebellum; Coculture Techniques; DNA Fragmentation; In Situ Nick-End Labeling; Interferon-gamma; L-Lactate Dehydrogenase; Lipopolysaccharides; Mice; Microglia; Molsidomine; N-Methylaspartate; Neurons; Nitrates; Nitric Oxide; Nitroarginine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Superoxide Dismutase | 1998 |
Inhibitory effects of mesoionic 3-aryl substituted oxatriazole-5-imine derivatives on vascular smooth muscle cell mitogenesis and proliferation in vitro.
Topics: Animals; Cell Division; Cells, Cultured; Cyclic GMP; DNA; Male; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitrites; Penicillamine; Rats; Rats, Wistar; Signal Transduction; Triazoles; Urea | 1998 |
Endothelial damage due to ischemia and reperfusion is prevented with SIN-1.
Topics: Animals; Endothelium, Vascular; Hindlimb; Male; Molsidomine; Rabbits; Reperfusion Injury; Sodium-Potassium-Exchanging ATPase; Vasodilation; Vasodilator Agents | 1998 |
Rapid and delayed p42/p44 mitogen-activated protein kinase activation by nitric oxide: the role of cyclic GMP and tyrosine phosphatase inhibition.
Topics: Acetylcysteine; Animals; Biphenyl Compounds; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic GMP; Enzyme Activation; Free Radical Scavengers; Glomerular Mesangium; Glutathione; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molsidomine; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Onium Compounds; Oxadiazoles; Oxazines; Phosphorylation; Protein Processing, Post-Translational; Protein Tyrosine Phosphatases; Rats; S-Nitrosoglutathione; Second Messenger Systems | 1998 |
The effect of nitric oxide and peroxynitrite on apoptosis in human polymorphonuclear leukocytes.
Topics: Annexin A5; Apoptosis; Flow Cytometry; Humans; Lipopolysaccharides; Lung; Molsidomine; Neutrophils; Nitrates; Nitric Oxide; Triazoles | 1998 |
Nitrate tolerance is specific for nitric acid esters and its recovery requires an intact protein synthesis.
Topics: Animals; Cell Line; Cyclic GMP; Cycloheximide; Kinetics; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Nitroglycerin; Nitroprusside; Protein Biosynthesis; Spermine; Vasodilator Agents | 1998 |
Nitric oxide donor-induced hyperpermeability of cultured intestinal epithelial monolayers: role of superoxide radical, hydroxyl radical, and peroxynitrite.
Topics: Antioxidants; Caco-2 Cells; Epithelial Cells; Free Radical Scavengers; Glutathione; Humans; Hydroxyl Radical; Intestinal Absorption; Intestines; Kinetics; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Permeability; Superoxide Dismutase; Superoxides | 1998 |
Concurrent generation of nitric oxide and superoxide inhibits proteoglycan synthesis in bovine articular chondrocytes: involvement of peroxynitrite.
Topics: Animals; Cartilage, Articular; Cattle; Chondrocytes; Immunohistochemistry; Interleukin-1; Molsidomine; Nitrates; Nitric Oxide; Proteoglycans; Superoxides | 1998 |
The NO-cGMP pathway in the rat locus coeruleus: electrophysiological, immunohistochemical and in situ hybridization studies.
Topics: Animals; Cyclic GMP; Excitatory Postsynaptic Potentials; Fluorescent Antibody Technique, Indirect; Hydrazines; In Situ Hybridization; In Vitro Techniques; Locus Coeruleus; Male; Molsidomine; Neural Pathways; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley | 1998 |
Neuronal death induced by SIN-1 in the presence of superoxide dismutase: protection by cyclic GMP.
Topics: Animals; Cell Death; Cyclic GMP; Drug Synergism; Enzyme Inhibitors; Hydrogen Peroxide; Molsidomine; Neurons; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Superoxide Dismutase; Vasodilator Agents | 1998 |
Nitric oxide-producing islet cells modulate the release of sensory neuropeptides in the rat substantia gelatinosa.
Topics: Animals; Axons; Calcitonin Gene-Related Peptide; Calcium; Enzyme Inhibitors; Fluorescent Dyes; Glutamic Acid; Immunohistochemistry; In Vitro Techniques; Male; Microscopy, Confocal; Molsidomine; NADPH Dehydrogenase; Neurons; Neuropeptides; Nitric Oxide; Presynaptic Terminals; Rats; Rats, Wistar; Substance P; Substantia Gelatinosa | 1998 |
Proliferation-dependent vulnerability of glucose-deprived astrocytes to nitric oxide-induced cytotoxicity.
Topics: Analysis of Variance; Animals; Animals, Newborn; Astrocytes; Cell Death; Cell Division; Cells, Cultured; Glucose; L-Lactate Dehydrogenase; Molsidomine; Nitric Oxide; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Time Factors | 1998 |
Inhibitory innervation of the guinea-pig urethra; roles of CO, NO and VIP.
Topics: Animals; Carbon Monoxide; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Female; Fluorescent Antibody Technique; Ganglia, Autonomic; Guinea Pigs; Heme Oxygenase (Decyclizing); Immunohistochemistry; Molsidomine; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Sodium-Potassium-Exchanging ATPase; Urethra; Urinary Bladder; Vasoactive Intestinal Peptide; Xanthenes | 1998 |
Regulation of noradrenaline release by S-nitroso-cysteine: inhibition in PC12 cells in a cyclic GMP-independent manner.
Topics: Animals; Calcium; Cyclic GMP; Cysteine; Molsidomine; Nitric Oxide; Nitroprusside; Nitroso Compounds; Norepinephrine; PC12 Cells; Rats; S-Nitrosothiols | 1998 |
Endogenous nitric oxide in the rat pons promotes sleep.
Topics: Anilides; Animals; Arginine; Behavior, Animal; Male; Microinjections; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pons; Rats; Rats, Wistar; Sleep; Tegmentum Mesencephali; Time Factors; Wakefulness | 1999 |
The peroxynitrite generator, SIN-1, becomes a nitric oxide donor in the presence of electron acceptors.
Topics: Animals; Cyclic N-Oxides; Free Radical Scavengers; Hemeproteins; Humans; Imidazoles; Kidney; Liver; Molsidomine; Myocardium; Nitrates; Nitric Oxide Donors; Oxidants; Rats | 1999 |
Nitric oxide induction of neuronal endonuclease activity in programmed cell death.
Topics: Animals; Apoptosis; Aurintricarboxylic Acid; Cells, Cultured; Endodeoxyribonucleases; Enzyme Induction; Ethylenediamines; Hippocampus; Hydrogen-Ion Concentration; Intracellular Fluid; Molsidomine; Neurons; Nitric Oxide; Nitroprusside; Rats; Rats, Sprague-Dawley | 1999 |
A comparative study of the effects of two nitric oxide synthase inhibitors and two nitric oxide donors on temporary focal cerebral ischemia in the Wistar rat.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indazoles; Ischemic Attack, Transient; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitroso Compounds; Rats; Rats, Wistar | 1999 |
Interaction of nitric oxide donors and ascorbic acid on D-[3H] aspartate efflux from rat striatal slices.
Topics: Animals; Ascorbic Acid; Aspartic Acid; Corpus Striatum; In Vitro Techniques; Kinetics; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Penicillamine; Potassium Cyanide; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Tritium | 1999 |
SIN-1-induced cytotoxicity in cultured endothelial cells involves reactive oxygen species and nitric oxide: protective effect of sepiapterin.
Topics: Animals; Antioxidants; Aorta; Benzoates; Biopterins; Catalase; Cattle; Cell Survival; Cells, Cultured; Endothelium, Vascular; Free Radical Scavengers; Imidazoles; Iron Chelating Agents; L-Lactate Dehydrogenase; Molsidomine; Nitric Oxide; Plant Extracts; Pteridines; Pterins; Reactive Oxygen Species; Superoxide Dismutase; Trypan Blue | 1999 |
Modulation of reperfusion injury after single lung transplantation by pentoxifylline, inositol polyanions, and sin-1.
Topics: Animals; Blood Platelets; Female; Free Radical Scavengers; Lung; Lung Transplantation; Malondialdehyde; Molsidomine; Neutrophils; Nitric Oxide Donors; Pentoxifylline; Phytic Acid; Pulmonary Circulation; Reperfusion Injury; Swine; Vascular Resistance | 1999 |
Acetylcholine-induced relaxation in blood vessels from endothelial nitric oxide synthase knockout mice.
Topics: Acetylcholine; Animals; Aorta; Blood Vessels; Carotid Arteries; Coronary Vessels; Cromakalim; Dose-Response Relationship, Drug; Electrophysiology; Endothelium, Vascular; Enzyme Inhibitors; Homozygote; In Vitro Techniques; Indomethacin; Membrane Potentials; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Knockout; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Mutation; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroarginine; Specific Pathogen-Free Organisms; Vasodilator Agents | 1999 |
Lack of interaction between nitric oxide and the redox modulatory site of the NMDA receptor.
Topics: Animals; Binding Sites; Cerebral Cortex; CHO Cells; Cricetinae; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Membrane Potentials; Molsidomine; N-Methylaspartate; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxidation-Reduction; Patch-Clamp Techniques; Penicillamine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins | 1999 |
In vitro simultaneous measurements of relaxation and nitric oxide concentration in rat superior mesenteric artery.
Topics: Acetylcholine; Animals; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Male; Mesenteric Artery, Superior; Microelectrodes; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Oxyhemoglobins; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine | 1999 |
The effect of alpha-tocopherol on the nitration of gamma-tocopherol by peroxynitrite.
Topics: Chelating Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Liposomes; Molsidomine; Nitrates; Oxidants; Pentetic Acid; Stereoisomerism; Tyrosine; Vitamin E | 1999 |
Salicylate inhibits LDL oxidation initiated by superoxide/nitric oxide radicals.
Topics: Free Radical Scavengers; Humans; Lipoproteins, LDL; Molsidomine; Nitric Oxide; Oxidation-Reduction; Salicylic Acid; Superoxides | 1999 |
Cytosolic myocardial calcium modulation by ATP-dependent potassium channel openers and NO donors.
Topics: Adenosine Triphosphate; Animals; Calcium; Cardiac Pacing, Artificial; Cytosol; Glyburide; Heart Ventricles; Hypoglycemic Agents; Male; Molsidomine; Myocardium; Nicorandil; Nitric Oxide Donors; Picolines; Potassium Channels; Pyrans; Rats; Rats, Wistar; Vasodilator Agents | 1999 |
2,5-Di-t-butyl-1,4-benzohydroquinone induces endothelium-dependent relaxation of rat thoracic aorta.
Topics: Animals; Aorta, Thoracic; Chelating Agents; Ditiocarb; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; Hydroquinones; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nickel; Phenylephrine; Rats; Rats, Wistar; Superoxide Dismutase; Superoxides; Vasoconstrictor Agents | 1999 |
Nitric oxide-mediated spinal disinhibition contributes to the sensitization of primate spinothalamic tract neurons.
Topics: Animals; Capsaicin; Electric Stimulation; Enzyme Inhibitors; Injections, Subcutaneous; Iontophoresis; Macaca fascicularis; Molsidomine; Neural Inhibition; Nitric Oxide Donors; Nitric Oxide Synthase; Periaqueductal Gray; Spinal Cord; Spinothalamic Tracts; Stress, Mechanical | 1999 |
Inhibition of primate spinothalamic tract neurons by spinal glycine and GABA is modulated by guanosine 3',5'-cyclic monophosphate.
Topics: Animals; Cyclic GMP; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glycine; Guanylate Cyclase; Iontophoresis; Macaca fascicularis; Male; Microdialysis; Molsidomine; Neural Inhibition; Neurons; Nitric Oxide Donors; Receptors, GABA; Receptors, Glycine; Spinothalamic Tracts | 1999 |
Nitric oxide and potassium chloride-facilitated striatal dopamine efflux in vivo: role of calcium-dependent release mechanisms.
Topics: Animals; Biological Transport; Corpus Striatum; Dopamine; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Potassium Chloride; Rats; Rats, Sprague-Dawley | 1998 |
Effective inhibition by beta-carotene of cellular DNA breaking induced by peroxynitrous acid.
Topics: Antioxidants; Ascorbic Acid; beta Carotene; Chromans; Dimethyl Sulfoxide; DNA; DNA Damage; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Free Radical Scavengers; Furans; HL-60 Cells; Humans; Mannitol; Microscopy, Fluorescence; Molsidomine; Nitrous Acid; Peroxynitrous Acid; Solubility; Sorbic Acid; Time Factors | 1999 |
Inhibition of bronchoprotective effects of beta2-adrenoceptor agonists by peroxynitrite in guinea pig airways.
Topics: Acetylcholine; Adrenergic beta-Agonists; Airway Resistance; Albuterol; Animals; Bronchoconstriction; Colforsin; Guinea Pigs; Isoproterenol; Male; Molsidomine; Nitrates; Penicillamine; Receptors, Adrenergic, beta-1 | 1999 |
Nitric oxide up-regulates the expression of intercellular adhesion molecule-1 on cancer cells.
Topics: Benzoates; Carcinoma, Squamous Cell; Cell Adhesion Molecules; Free Radical Scavengers; Genistein; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Molsidomine; NF-kappa B; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Penicillamine; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Staurosporine; Tongue Neoplasms; Transcription Factor AP-1; Tumor Cells, Cultured; Up-Regulation | 1999 |
Quantification of total oxidant scavenging capacity of antioxidants for peroxynitrite, peroxyl radicals, and hydroxyl radicals.
Topics: Amidines; Antioxidants; Ascorbic Acid; Chromatography, Gas; Free Radical Scavengers; Free Radicals; Hydroxyl Radical; Methionine; Molsidomine; Nitrates; Nitric Oxide Donors; Oxidants; Oxidation-Reduction; Peroxides | 1999 |
Regulation of intracellular polyamine biosynthesis and transport by NO and cytokines TNF-alpha and IFN-gamma.
Topics: 3T3 Cells; Animals; Biological Transport; Cell Line; Cell Line, Transformed; Dithiothreitol; Enzyme Inhibitors; Interferon-gamma; Kidney Tubules, Proximal; Lysine; Mice; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Ornithine Decarboxylase; Penicillamine; Polyamines; Rats; S-Nitroso-N-Acetylpenicillamine; Tumor Necrosis Factor-alpha | 1999 |
Growth factors prevent changes in Bcl-2 and Bax expression and neuronal apoptosis induced by nitric oxide.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Cell Survival; Cells, Cultured; Cysteine Proteinase Inhibitors; DNA Fragmentation; Embryo, Mammalian; Fibroblast Growth Factor 2; Gene Expression Regulation; Growth Substances; Hippocampus; Insulin-Like Growth Factor I; Molsidomine; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oligopeptides; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Transcription, Genetic | 1998 |
Antinociception after both peripheral and intrathecal injection of oxotremorine is modulated by spinal nitric oxide.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Injections, Intraperitoneal; Injections, Spinal; Male; Molsidomine; Muscarinic Agonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nociceptors; Oxotremorine; Pain; Pain Measurement; Rats; Rats, Wistar; Spinal Cord | 1999 |
Formation of phospholipid hydroperoxides and its inhibition by alpha-tocopherol in rat brain synaptosomes induced by peroxynitrite.
Topics: Acetophenones; Animals; Antioxidants; Brain; Dose-Response Relationship, Drug; Hydrogen Peroxide; Male; Molsidomine; Nitrates; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipases A; Phospholipases A2; Phospholipids; Rats; Rats, Wistar; Superoxide Dismutase; Synaptosomes; Time Factors; Vitamin E | 1999 |
Carnosine and taurine protect rat cerebellar granular cells from free radical damage.
Topics: Animals; Carnosine; Cell Survival; Cerebellum; Free Radicals; Kainic Acid; Molsidomine; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Taurine | 1999 |
Inhibition by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) of responses to nitric oxide-donors in rat pulmonary artery: influence of the mechanism of nitric oxide generation.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; In Vitro Techniques; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Nitrogen Oxides; Oxadiazoles; Pulmonary Artery; Quinoxalines; Rats; Rats, Wistar; Spermine; Vasodilation | 1999 |
Cooperativity between oxidants and tumor necrosis factor in the activation of nuclear factor (NF)-kappaB: requirement of Ras/mitogen-activated protein kinases in the activation of NF-kappaB by oxidants.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Transformed; DNA-Binding Proteins; Enzyme Activation; Hydrogen Peroxide; I-kappa B Proteins; Molsidomine; NF-kappa B; Oxidative Stress; ras Proteins; Rats; Tumor Necrosis Factor-alpha | 1999 |
Contrasting roles for nitric oxide and peroxynitrite in the peroxidation of myelin lipids.
Topics: Animals; Central Nervous System; Dinoprost; Encephalomyelitis, Autoimmune, Experimental; F2-Isoprostanes; Lipid Peroxidation; Mice; Molsidomine; Myelin Proteins; Myelin Sheath; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidants; Penicillamine | 1999 |
Regulation of neuronal growth cone filopodia by nitric oxide.
Topics: Animals; Calcium; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Growth Cones; Guanylate Cyclase; Hydrazines; Molsidomine; Mutagens; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Nitroprusside; Oxadiazoles; Pseudopodia; Quinoxalines; Snails; Sulfhydryl Reagents | 1999 |
Shear stress-induced nitric oxide antagonizes adenosine effects on intestinal metabolism.
Topics: Adenosine; Animals; Blood Flow Velocity; Cats; Drug Synergism; Enzyme Inhibitors; Female; Hemorheology; Intestine, Small; Lactic Acid; Male; Mesenteric Artery, Superior; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxygen; Oxygen Consumption; Vasodilation | 1999 |
Delayed endothelial protective effects of monophosphoryl lipid A after myocardial ischemia and reperfusion in rats.
Topics: Acetylcholine; Adjuvants, Immunologic; Animals; Cytoprotection; Endothelium, Vascular; Lipid A; Logistic Models; Male; Molsidomine; Myocardial Reperfusion Injury; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Serotonin; Time Factors; Vasodilator Agents | 1999 |
Gastroepiploic bypass graft stenting.
Topics: Angina, Unstable; Arteries; Coronary Artery Bypass; Coronary Disease; Graft Occlusion, Vascular; Humans; Molsidomine; Stents; Stomach; Vasodilator Agents | 1999 |
Requirement for nitric oxide in retinal neuronal cell death induced by activated Müller glial cells.
Topics: Animals; Animals, Newborn; Cell Survival; Cells, Cultured; Coculture Techniques; Humans; Interferon-gamma; Isoenzymes; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Molsidomine; Neuroglia; Neurons; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroso Compounds; omega-N-Methylarginine; Recombinant Proteins; Retina; Salmonella typhimurium; Superoxide Dismutase; Transforming Growth Factor beta | 1999 |
The nitric oxide donor SIN-1 is free of tolerance and maintains its cyclic GMP stimulatory potency in nitrate-tolerant LLC-PK1 cells.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Guanylate Cyclase; LLC-PK1 Cells; Molsidomine; Mutagens; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Nitroglycerin; Nitroprusside; Spermine; Swine; Vasodilator Agents | 1999 |
Nitric oxide does not affect histamine release from rat peritoneal mast cells.
Topics: Animals; Enzyme Inhibitors; Histamine Release; Mast Cells; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Peritoneum; Rats; Rats, Sprague-Dawley; Rats, Wistar | 1999 |
Aortic endothelial cells damaged by a nitric oxide donor and protected by flavonoids.
Topics: Animals; Aorta; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Flavonoids; Molsidomine; Necrosis; Nitric Oxide Donors; Swine | 1999 |
Effect of nitric oxide donors on renal tubular epithelial cell-matrix adhesion.
Topics: Animals; Cell Adhesion; Cell Line; Chlorocebus aethiops; Collagen; Epithelial Cells; Fibronectins; Free Radical Scavengers; Kidney Tubules; LLC-PK1 Cells; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Opossums; Superoxides; Swine | 1999 |
Analysis of 3-nitrotyrosine in biological fluids and protein hydrolyzates by high-performance liquid chromatography using a postseparation, on-line reduction column and electrochemical detection: results with various nitrating agents.
Topics: Chromatography, High Pressure Liquid; Electrochemistry; Humans; Hypochlorous Acid; Indicators and Reagents; Molsidomine; Nitrates; Nitrites; Nitrogen Oxides; Serum Albumin, Bovine; Sodium Nitrite; Spectrophotometry, Ultraviolet; Spermine; Tyrosine | 1999 |
Immunostimulated glial cells potentiate glucose deprivation-induced death of cultured rat cerebellar granule cells.
Topics: Animals; Animals, Newborn; Cell Death; Cells, Cultured; Cerebellum; Coculture Techniques; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Glucose; Interferon-gamma; Kinetics; Lipopolysaccharides; Microtubule-Associated Proteins; Molsidomine; Neuroglia; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Penicillamine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine | 1999 |
Actions of 8-bromo-cyclic-GMP on neurones in the rat thalamus in vivo and in vitro.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cyclic GMP; Evoked Potentials, Visual; Excitatory Amino Acid Agonists; Geniculate Bodies; Guanylate Cyclase; In Vitro Techniques; Molsidomine; N-Methylaspartate; Neurons, Afferent; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Wistar | 1999 |
Cytotoxic versus genotoxic effects of nitric oxide (NO).
Topics: Animals; Cell Division; DNA Damage; Dose-Response Relationship, Drug; Mice; Micronucleus Tests; Molsidomine; Mutagens; Nitric Oxide; Tumor Cells, Cultured | 1999 |
Positive and negative inotropic effects of NO donors in atrial and ventricular fibres of the frog heart.
Topics: Aminoquinolines; Animals; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Half-Life; Heart; Heart Atria; Heart Ventricles; In Vitro Techniques; Molsidomine; Muscle Fibers, Skeletal; Myocardial Contraction; Nitric Oxide Donors; Nitroprusside; Penicillamine; Rana esculenta; S-Nitroso-N-Acetylpenicillamine | 1999 |
Up-regulation of heme-binding protein 23 (HBP23) gene expression by lipopolysaccharide is mediated via a nitric oxide-dependent signaling pathway in rat Kupffer cells.
Topics: Animals; Carrier Proteins; Cell Survival; Cells, Cultured; Cyclic GMP; Cytochrome-B(5) Reductase; Gene Expression Regulation; Heme-Binding Proteins; Hemeproteins; Kinetics; Kupffer Cells; Lipopolysaccharides; Male; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Penicillamine; Protein Biosynthesis; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Transcription, Genetic | 1999 |
Thiols mediate superoxide-dependent NADH modification of glyceraldehyde-3-phosphate dehydrogenase.
Topics: Animals; Ascorbic Acid; Catalase; Chelating Agents; Cholera Toxin; Chromatography, High Pressure Liquid; Dithiothreitol; Glyceraldehyde-3-Phosphate Dehydrogenases; Metalloendopeptidases; Molsidomine; Muscle, Skeletal; NAD; Nitric Oxide; Nitroprusside; Rabbits; Reactive Oxygen Species; Spectrophotometry; Sulfhydryl Compounds; Superoxide Dismutase; Superoxides; Xanthine Oxidase | 1999 |
p130cas is a cellular target protein for tyrosine nitration induced by peroxynitrite.
Topics: Crk-Associated Substrate Protein; Humans; Molsidomine; Neuroblastoma; Nitrates; Nitric Oxide Donors; Oxidants; Phosphoproteins; Phosphorylation; Proteins; Retinoblastoma-Like Protein p130; Tumor Cells, Cultured; Tyrosine | 1999 |
The neuromuscular transmission fade (Wedensky inhibition) induced by L-arginine in neuromuscular preparations from rats.
Topics: Animals; Arginine; Diaphragm; Electric Stimulation; Enzyme Inhibitors; Female; In Vitro Techniques; Male; Molsidomine; Muscle Contraction; Muscle, Skeletal; Neuromuscular Junction; Nitroarginine; Oxadiazoles; Phrenic Nerve; Quinoxalines; Rats; Rats, Wistar; Synaptic Transmission | 1999 |
Nitric oxide synthase inhibitors enhance 5-HT2 receptor-mediated behavior, the head-twitch response in mice.
Topics: Animals; Arginine; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Head Movements; Male; Methylene Blue; Mice; Mice, Inbred ICR; Molsidomine; N-Methylaspartate; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Penicillamine; Receptors, Serotonin; Serotonin; Serotonin Antagonists | 1999 |
Cyclic GMP regulates cromakalim-induced relaxation in the rat aortic smooth muscle: role of cyclic GMP in K(ATP)-channels.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Apamin; Calcium; Charybdotoxin; Cromakalim; Cyclic GMP; Endothelium, Vascular; Glyburide; In Vitro Techniques; Male; Methylene Blue; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Inbred WKY | 1999 |
Site-specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening.
Topics: Base Sequence; Copper; Deoxyguanine Nucleotides; Deoxyguanosine; DNA Damage; Hydrogen Peroxide; Hydroxylation; Molsidomine; Oligonucleotides; Oxidative Stress; Telomere | 1999 |
Blockade of hepatic nitric oxide synthase causes insulin resistance.
Topics: Animals; Denervation; Enzyme Inhibitors; Injections; Injections, Intravenous; Insulin Resistance; Liver; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; omega-N-Methylarginine; Portal System; Rats; Rats, Sprague-Dawley | 1999 |
Neuronal intracellular pH directly mediates nitric oxide-induced programmed cell death.
Topics: Animals; Apoptosis; Caspases; DNA Fragmentation; Endonucleases; Fluoresceins; Fluorescent Dyes; Hippocampus; Hydrazines; Hydrogen-Ion Concentration; Intracellular Fluid; Molsidomine; Nerve Tissue Proteins; Neurons; Nitric Acid; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Triazenes | 1999 |
Potential interactions between iloprost and SIN-1 on platelet aggregation and myocardial infarct size in vivo.
Topics: Animals; Arrhythmias, Cardiac; Creatine Kinase; Drug Synergism; Electrocardiography; Hemodynamics; Iloprost; Male; Molsidomine; Myocardial Infarction; Platelet Aggregation; Rabbits | 1999 |
Induction of heme oxygenase-1 as a response in sensing the signals evoked by distinct nitric oxide donors.
Topics: Adenocarcinoma; Colorectal Neoplasms; Drug Synergism; Enzyme Induction; Gene Expression Regulation, Neoplastic; Glutathione; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Membrane Proteins; Molsidomine; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Promoter Regions, Genetic; RNA, Messenger; S-Nitrosoglutathione; Signal Transduction; Tumor Cells, Cultured | 1999 |
Effects of reactive oxygen and nitrogen metabolites on RANTES- and IL-5-induced eosinophil chemotactic activity in vitro.
Topics: Chemokine CCL5; Chemotaxis; Deferoxamine; Dithiothreitol; Dose-Response Relationship, Drug; Eosinophils; Humans; Hydrazines; Interleukin-5; Leukotriene B4; Molsidomine; Nitrates; Nitric Oxide; Nitrogen; Pteridines; Reactive Oxygen Species; Superoxides; Tyrosine; Xanthine | 1999 |
Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm5F cells.
Topics: Animals; Antioxidants; Catalase; Cytotoxicity, Immunologic; DEET; Drug Synergism; Gene Expression; Glutathione Peroxidase; Hydrogen Peroxide; Hypoxanthine; Islets of Langerhans; Molsidomine; Nitric Oxide Donors; Nitroprusside; Penicillamine; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine; Superoxide Dismutase; Tumor Cells, Cultured | 1999 |
The survival of skeletal muscle myoblasts in vitro is sensitive to a donor of nitric oxide and superoxide, SIN-1, but not to nitric oxide or peroxynitrite alone.
Topics: Animals; Cell Line; Cell Survival; Molsidomine; Muscle, Skeletal; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxyhemoglobins; Rats; Superoxide Dismutase; Superoxides; Uric Acid; Xanthine Oxidase | 1999 |
Activity of ovarian nitric oxide synthase (NOs) during ovulatory process in the rat: relationship with prostaglandins (PGs) production.
Topics: Animals; Chorionic Gonadotropin; Dinoprost; Enzyme Activation; Enzyme Inhibitors; Female; Gonadotropins, Equine; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Ovary; Ovulation; Ovulation Induction; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Rats; Rats, Wistar | 1999 |
Peroxynitrite induces contractile dysfunction and lipid peroxidation in the diaphragm.
Topics: Aldehydes; Animals; Calcium; Diaphragm; Kinetics; Lipid Peroxidation; Molsidomine; Muscle Contraction; Nitrates; Nitric Oxide Donors; Rats; Thiobarbituric Acid Reactive Substances | 1999 |
Inhibitory effect of nitric oxide on chemically induced differentiation of human leukemic K562 cells.
Topics: Antibiotics, Antineoplastic; Cell Division; Erythropoiesis; Humans; K562 Cells; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Penicillamine; RNA, Messenger; Tumor Cells, Cultured | 1999 |
Reaction of peroxynitrite with reduced nicotinamide nucleotides, the formation of hydrogen peroxide.
Topics: Free Radical Scavengers; Free Radicals; Glutathione; Hydrogen Peroxide; Molsidomine; NAD; NADP; Nitrates; Superoxides | 1999 |
Nitric oxide stimulates ACTH secretion and the transcription of the genes encoding for NGFI-B, corticotropin-releasing factor, corticotropin-releasing factor receptor type 1, and vasopressin in the hypothalamus of the intact rat.
Topics: Adrenocorticotropic Hormone; Amygdala; Animals; Cerebral Ventricles; Corticotropin-Releasing Hormone; DNA-Binding Proteins; Gene Expression Regulation; Genes, Immediate-Early; Hypothalamus; Ibuprofen; Injections, Intraventricular; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nuclear Receptor Subfamily 4, Group A, Member 1; Organ Specificity; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Supraoptic Nucleus; Transcription Factors; Transcription, Genetic; Vasopressins | 1999 |
Galpha(i2), Galpha(i3)and Galpha(o) are all required for normal muscarinic inhibition of the cardiac calcium channels in nodal/atrial-like cultured cardiocytes.
Topics: Action Potentials; Animals; Calcium Channels; Calcium Channels, L-Type; Carbachol; Cell Line; GTP-Binding Proteins; Heart; Heart Ventricles; Isoproterenol; Mice; Models, Cardiovascular; Molsidomine; Muscarinic Antagonists; Myocardium; Nifedipine; Nitric Oxide Donors; omega-N-Methylarginine; Pertussis Toxin; Receptors, Muscarinic; Stem Cells; Virulence Factors, Bordetella | 1999 |
Nitric oxide modulates beta(2)-adrenergic receptor palmitoylation and signaling.
Topics: Adenylyl Cyclases; Animals; Cell Line; COS Cells; Cyclic AMP; Enzyme Activation; GTP-Binding Proteins; Humans; Isoproterenol; Macrophages; Molsidomine; Mutagenesis, Site-Directed; Nitric Oxide; Nitric Oxide Donors; Oxidation-Reduction; Palmitic Acid; Receptors, Adrenergic, beta-2; Signal Transduction | 1999 |
Effects of nitric oxide donors GEA 3162 and SIN-1 on ethanol-induced gastric ulceration in rats.
Topics: Animals; Blood Pressure; Dinoprostone; Ethanol; Gastric Mucosa; Male; Molsidomine; Nitric Oxide Donors; Rats; Rats, Wistar; Stomach Ulcer; Triazoles | 1999 |
Elevated production of salivary nitric oxide in oral mucosal diseases.
Topics: Adult; Cell Line; Cell Size; Cell Survival; Dose-Response Relationship, Drug; Female; Humans; Lichen Planus, Oral; Male; Molsidomine; Mouth Diseases; Mouth Mucosa; Nitric Oxide; Nitric Oxide Donors; Oral Ulcer; Penicillamine; Saliva; Salivary Glands | 1999 |
Rapid and irreversible inactivation of protein tyrosine phosphatases PTP1B, CD45, and LAR by peroxynitrite.
Topics: Aniline Compounds; Anions; Dithiothreitol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione; Humans; Leukocyte Common Antigens; Models, Molecular; Molsidomine; Nitrates; Nitric Oxide; Nitroso Compounds; Organophosphates; Organophosphorus Compounds; Protein Tyrosine Phosphatases; Receptor-Like Protein Tyrosine Phosphatases, Class 4; Receptors, Cell Surface; S-Nitrosoglutathione; Superoxide Dismutase; Tyrosine | 1999 |
Formation of guanidinosuccinic acid, a stable nitric oxide mimic, from argininosuccinic acid and nitric oxide-derived free radicals.
Topics: Argininosuccinic Acid; Benzoates; Chromatography, High Pressure Liquid; Dimethyl Sulfoxide; Feedback; Free Radical Scavengers; Free Radicals; Guanidines; Hydrazines; Hydroxyl Radical; Imidazoles; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Succinates; Superoxide Dismutase | 1999 |
Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader.
Topics: Amidines; Animals; Dopamine; Fluoresceins; Fluorescent Dyes; Free Radicals; Hydrogen Peroxide; Molsidomine; Nitric Oxide Donors; Nitroprusside; Oxidants; Oxidative Stress; PC12 Cells; Rats | 1999 |
Interaction of heme oxygenase-2 with nitric oxide donors. Is the oxygenase an intracellular 'sink' for NO?
Topics: Animals; Base Sequence; Binding Sites; DNA Primers; Escherichia coli; HeLa Cells; Heme; Heme Oxygenase (Decyclizing); Humans; In Vitro Techniques; Ligands; Molsidomine; Mutagenesis, Site-Directed; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Rats; Recombinant Proteins; RNA, Messenger | 1999 |
Mitogen-activated protein kinase pathway mediates peroxynitrite-induced apoptosis in human dopaminergic neuroblastoma SH-SY5Y cells.
Topics: Antioxidants; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Caspase 3; Caspase Inhibitors; Caspases; DNA Fragmentation; Dopamine; Enzyme Activation; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Molsidomine; Neuroblastoma; Neurodegenerative Diseases; Neurons; Nitrates; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Superoxides; Tumor Cells, Cultured | 1999 |
Regulation of prostaglandin H2 synthase activity by nitrogen oxides.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Cells, Cultured; Cyclooxygenase 1; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; Hydrazines; Isoenzymes; Male; Membrane Proteins; Molsidomine; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Penicillamine; Peroxides; Prostaglandin Antagonists; Prostaglandin-Endoperoxide Synthases; Rats; S-Nitroso-N-Acetylpenicillamine; Sheep; Superoxides | 1999 |
Melatonin inhibits the vasorelaxant action of peroxynitrite in human umbilical artery.
Topics: Antioxidants; Female; Free Radical Scavengers; Humans; In Vitro Techniques; Melatonin; Molsidomine; Nitrates; Nitric Oxide Donors; Pre-Eclampsia; Pregnancy; Umbilical Arteries; Vasodilation | 1999 |
Inhibition of cathepsin K by nitric oxide donors: evidence for the formation of mixed disulfides and a sulfenic acid.
Topics: Animals; Catalysis; Cathepsin K; Cathepsins; CHO Cells; Cricetinae; Disulfides; Dose-Response Relationship, Drug; Enzyme Activation; Gas Chromatography-Mass Spectrometry; Glutathione; Humans; Hydrogen-Ion Concentration; Molsidomine; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Penicillamine; Protease Inhibitors; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Sulfenic Acids; Time Factors | 1999 |
Nitric oxide-releasing compounds inhibit neutrophil adhesion to endothelial cells.
Topics: Animals; CD11 Antigens; CD18 Antigens; Cell Adhesion; Coculture Techniques; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Molsidomine; Neutrophils; Nitric Oxide Donors; Rabbits; Thionucleotides; Triazoles; Tumor Necrosis Factor-alpha | 1999 |
Laccase protects Cryptococcus neoformans from antifungal activity of alveolar macrophages.
Topics: Animals; Cryptococcus neoformans; Female; Hydroxyl Radical; Iron; Laccase; Macrophages, Alveolar; Mice; Molsidomine; Oxidoreductases; Phagocytosis; Recombinant Proteins | 1999 |
Astrocytes prevent neuronal death induced by reactive oxygen and nitrogen species.
Topics: Animals; Ascorbic Acid; Astrocytes; Cell Culture Techniques; Cell Death; Coloring Agents; Extracellular Matrix; Ferric Compounds; Fibronectins; Free Radical Scavengers; Hydroxyl Radical; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; Indicators and Reagents; Laminin; Microtubule-Associated Proteins; Molsidomine; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxazines; Oxidative Stress; Rats; Reactive Oxygen Species; Xanthenes | 1999 |
Pharmacological manipulation of central nitric oxide/guanylate cyclase activity alters Fos expression by rat hypothalamic vasopressinergic neurons during acute glucose deprivation.
Topics: Animals; Deoxyglucose; Enzyme Inhibitors; Glucose; Guanylate Cyclase; Hypothalamus; Immunoenzyme Techniques; Male; Molsidomine; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Proto-Oncogene Proteins c-fos; Quinoxalines; Rats; Rats, Sprague-Dawley; Transcription Factor AP-1; Vasopressins | 1999 |
Peroxynitrite is a positive inotropic agent in atrial and ventricular fibres of the frog heart.
Topics: Aminoquinolines; Animals; Atrial Function; Catalase; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Heart Atria; Heart Ventricles; Hydroxyl Radical; Molsidomine; Muscle Fibers, Skeletal; Myocardial Contraction; Myocardium; Nitrates; Nitric Oxide Donors; Oxadiazoles; Oxidants; Quinoxalines; Rana esculenta; Sodium; Sodium-Calcium Exchanger; Ventricular Function | 1999 |
Nitric oxide and l-arginine cause an accumulation of utrophin at the sarcolemma: a possible compensation for dystrophin loss in Duchenne muscular dystrophy.
Topics: Animals; Arginine; Cell Line; Cytoskeletal Proteins; Dystrophin; Hydroxyurea; Membrane Proteins; Mice; Mice, Inbred C57BL; Molsidomine; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Nitric Oxide; Nitric Oxide Donors; Utrophin | 1999 |
Stimulation-induced changes in filopodial dynamics determine the action radius of growth cones in the snail Helisoma trivolvis.
Topics: Animals; Cells, Cultured; Growth Cones; Helix, Snails; Molsidomine; Neurons; Nitric Oxide; Nitric Oxide Donors; Pseudopodia; Time Factors | 1999 |
Nitric oxide generation, tachyphylaxis and cross-tachyphylaxis from nitrovasodilators in vivo.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Female; Isosorbide Dinitrate; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Rabbits; Tachyphylaxis; Vasodilator Agents | 1999 |
Dioclein, a new nitric oxide- and endothelium-dependent vasodilator flavonoid.
Topics: Animals; Aorta, Thoracic; Brazil; Cyclic GMP; Endothelium, Vascular; Flavanones; Flavonoids; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Nitric Oxide; Phenylephrine; Plant Roots; Plants, Medicinal; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasodilator Agents | 1999 |
Nitric oxide inhibits falcipain, the Plasmodium falciparum trophozoite cysteine protease.
Topics: Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dithiothreitol; Glutathione; Kinetics; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Nitroprusside; Nitroso Compounds; Plasmodium falciparum; S-Nitrosoglutathione | 2000 |
Enhancement by glucose of low density lipoprotein-oxidation by peroxynitrite.
Topics: Glucose; Humans; Kinetics; Lipoproteins, LDL; Male; Mannitol; Middle Aged; Molsidomine; Nitrates; Nitric Oxide Donors; Oxidants; Oxidation-Reduction | 1999 |
Evolution of streptozotocin-pancreatic damage in the rat: modulatory effect of endothelins on the nitridergic and prostanoid pathway.
Topics: Animals; Arachidonic Acid; Diabetes Mellitus, Experimental; Dinoprost; Dinoprostone; Endothelin-1; Endothelins; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitrogen Oxides; omega-N-Methylarginine; Pancreas; Rats; Rats, Wistar; Spermine; Streptozocin; Thromboxane B2 | 1999 |
Effects of nitric oxide and prostacyclin on deformability and aggregability of red blood cells of rats ex vivo and in vitro.
Topics: Animals; Aspirin; Drug Interactions; Enzyme Inhibitors; Epoprostenol; Erythrocyte Aggregation; Erythrocyte Deformability; Iloprost; In Vitro Techniques; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Platelet Aggregation Inhibitors; Rats; Rats, Wistar | 1999 |
Administration of SIN-1 induces guinea pig airway hyperresponsiveness through inactivation of airway neutral endopeptidase.
Topics: Animals; Bronchial Hyperreactivity; Bronchoconstriction; Endothelin-1; Enzyme Activation; Glycopeptides; Guinea Pigs; Male; Molsidomine; Neprilysin; Nitrates; Oxidants; Protease Inhibitors; Respiratory System; Substance P; Trachea; Vasodilator Agents | 1999 |
Calmodulin-dependent activation of p38 and p42/44 mitogen-activated protein kinases contributes to c-fos expression by calcium in PC12 cells: modulation by nitric oxide.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, fos; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Potassium Chloride; Proto-Oncogene Proteins c-fos; Pyridines; Quinoxalines; Rats; Sulfonamides | 2000 |
DNA damage in arsenite- and cadmium-treated bovine aortic endothelial cells.
Topics: Amitrole; Animals; Antioxidants; Aorta; Arsenites; Bacterial Proteins; Cadmium Chloride; Catalase; Cattle; Cells, Cultured; Chromans; Citrulline; Ditiocarb; DNA Damage; DNA-Formamidopyrimidine Glycosylase; Endothelium, Vascular; Enzyme Inhibitors; Escherichia coli Proteins; Free Radical Scavengers; Hydrogen Peroxide; Molsidomine; Mutagens; N-Glycosyl Hydrolases; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Onium Compounds; Phenanthrolines; Reactive Oxygen Species; Sodium Compounds; Sodium Selenite; Superoxide Dismutase; Superoxides; Thiomalates; Thiourea; Uric Acid | 2000 |
Effect of procyanidins from Pinus maritima on glutathione levels in endothelial cells challenged by 3-morpholinosydnonimine or activated macrophages.
Topics: Animals; Biflavonoids; Catechin; Cell Line; Cells, Cultured; Endothelium, Vascular; Glutathione; Humans; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Mice; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Plant Extracts; Proanthocyanidins; Trees | 1999 |
Stabilization of growing retinal axons by the combined signaling of nitric oxide and brain-derived neurotrophic factor.
Topics: Animals; Axons; Brain-Derived Neurotrophic Factor; Cells, Cultured; Chick Embryo; Ganglia, Spinal; Heart; Hydrazines; Molsidomine; Neurons; Neurotrophin 3; Nitric Oxide; Nitric Oxide Donors; Organ Culture Techniques; Retina; Signal Transduction; Visual Pathways | 2000 |
Decreased synthesis and vasodilation to nitric oxide in piglets with hypoxia-induced pulmonary hypertension.
Topics: Animals; Animals, Newborn; Arginine; Blood Vessels; Cyclic GMP; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pulmonary Circulation; Swine; Vasodilation; Vasodilator Agents | 2000 |
Different effects of reactive nitrogen intermediates on prostaglandin E2 synthesis in cultured rat microglia and RAW 264.7 cells.
Topics: Animals; Arachidonic Acid; Cell Line; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Isoenzymes; Macrophages; Mice; Microglia; Molsidomine; Monocytes; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; omega-N-Methylarginine; Penicillamine; Prostaglandin-Endoperoxide Synthases; Rats | 1999 |
Investigation of the interaction between nitric oxide and vasoactive intestinal polypeptide in the guinea-pig gastric fundus.
Topics: Adenine; Adrenergic beta-Agonists; Animals; Atrial Natriuretic Factor; Carbachol; Colforsin; Cyclic AMP; Dexamethasone; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; Guinea Pigs; In Vitro Techniques; Isoproterenol; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroarginine; Nitroprusside; Pinacidil; Tetrodotoxin; Thionucleotides; Vasoactive Intestinal Peptide | 2000 |
Fos expression is induced by increased nitric oxide release in rat spinal cord dorsal horn.
Topics: Animals; Blotting, Western; Gene Expression Regulation; Immunohistochemistry; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Statistical Distributions | 2000 |
Possible mechanism of bronchoprotection by SIN-1 in anaesthetized guinea pigs: roles of nitric oxide and peroxynitrite.
Topics: Acetylcholine; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agents; Dose-Response Relationship, Drug; Glutathione; Guinea Pigs; Male; Molsidomine; Nebulizers and Vaporizers; Nitrates; Nitric Oxide; Penicillamine; Rhodamines; Time Factors; Vasodilator Agents | 2000 |
Impaired relaxation of stomach smooth muscle in mice lacking cyclic GMP-dependent protein kinase I.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Electric Stimulation; Female; Fluorescent Antibody Technique; Immunohistochemistry; Male; Mice; Mice, Knockout; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroarginine; Receptor Cross-Talk; Signal Transduction; Stomach; Vasoactive Intestinal Peptide | 2000 |
Inhibition of MIP-1alpha-induced human neutrophil and monocyte chemotactic activity by reactive oxygen and nitrogen metabolites.
Topics: Chemokine CCL3; Chemokine CCL4; Chemotaxis, Leukocyte; Complement System Proteins; Deferoxamine; Humans; Hydrazines; In Vitro Techniques; Leukotriene B4; Macrophage Inflammatory Proteins; Molsidomine; Monocytes; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidants | 2000 |
Free radicals and apoptosis of the endothelial cells.
Topics: Animals; Aorta; Apoptosis; Caspase 3; Caspases; DNA Fragmentation; Endothelium, Vascular; Free Radicals; Mice; Molsidomine; Nitrates; Nitric Oxide Donors; Oxidants; Swine | 2000 |
Despite the internucleosomal cleavage of DNA, reactive oxygen species do not produce other markers of apoptosis in cultured neurons.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Caspases; Cell Nucleus; Cholinesterase Inhibitors; Comet Assay; Cycloheximide; DNA Fragmentation; Enzyme Inhibitors; Female; Free Radical Scavengers; Glutamic Acid; Metalloporphyrins; Molsidomine; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Nucleosomes; Oxidation-Reduction; Phenanthrolines; Pregnancy; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Staurosporine; Uric Acid | 2000 |
Sodium nitroprusside prevents chemical hypoxia-induced cell death through iron ions stimulating the activity of the Na+-Ca2+ exchanger in C6 glioma cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amiloride; Animals; Bepridil; Calcium; Calcium Channel Blockers; Cell Hypoxia; Cell Survival; Chelating Agents; Chlorides; Deferoxamine; Enzyme Activation; Extracellular Space; Ferric Compounds; Ferricyanides; Fluoresceins; Glioma; L-Lactate Dehydrogenase; Molsidomine; Nitric Oxide; Nitroprusside; Sodium; Sodium Channels; Sodium-Calcium Exchanger; Staining and Labeling; Tetrodotoxin; Tumor Cells, Cultured; Vasodilator Agents | 2000 |
Nitric oxide inhibits norepinephrine-induced hepatic vascular responses but potentiates hepatic glucose output.
Topics: Animals; Cats; Female; Glucose; Hemodynamics; Indomethacin; Liver; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Portal System; Prostaglandins; Rats; Rats, Sprague-Dawley | 2000 |
Regulation of prostaglandin E2 production by the superoxide radical and nitric oxide in mouse peritoneal macrophages.
Topics: Animals; Arachidonic Acid; Cyclooxygenase 2; Dinoprostone; Isoenzymes; Kinetics; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Phospholipases A; Prostaglandin-Endoperoxide Synthases; Superoxides | 2000 |
Increased flow precedes remote arteriolar dilations for some microapplied agonists.
Topics: Adenosine; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arterioles; Blood Flow Velocity; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Male; Mesocricetus; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Papaverine; Receptors, Vitronectin; Tetrodotoxin; Vasodilation; Vasodilator Agents | 2000 |
Cyclic GMP attenuates cyclic AMP-stimulated inotropy and oxygen consumption in control and hypertrophic hearts.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Cyclic AMP; Cyclic GMP; Isoproterenol; Molsidomine; Myocardial Contraction; Oxygen Consumption; Rabbits; Vasodilator Agents | 2000 |
Reactive nitrogen and oxygen species attenuate interleukin- 8-induced neutrophil chemotactic activity in vitro.
Topics: Chemotaxis, Leukocyte; Humans; Interleukin-8; Leukotriene B4; Molsidomine; Neutrophils; Nitrates; Nitric Oxide Donors; Tyrosine | 2000 |
Paradoxical actions of the NO donor SIN-I on single laryngeal motoneurons in the nucleus ambiguus.
Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Laryngeal Nerves; Male; Medulla Oblongata; Molsidomine; Motor Neurons; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Wistar | 2000 |
Behavioral and c-fos expression changes induced by nitric oxide donors microinjected into the dorsal periaqueductal gray.
Topics: Animals; Behavior, Animal; Brain Mapping; Hydrazines; Immunohistochemistry; Male; Microinjections; Molsidomine; Neural Pathways; Nitric Oxide Donors; Nitrogen Oxides; Periaqueductal Gray; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar | 2000 |
The effects of pregnancy and smooth muscle contractility on cervical distensibility in the rat.
Topics: Animals; Cervix Uteri; Compliance; Female; In Vitro Techniques; Labor, Obstetric; Molsidomine; Muscle Contraction; Muscle, Smooth; Neuromuscular Depolarizing Agents; Nitric Oxide Donors; Potassium Chloride; Pregnancy; Pregnancy, Animal; Pressure; Rats; Rats, Sprague-Dawley | 2000 |
Determination of linsidomine in human plasma by tandem LC-MS with ESI.
Topics: Chromatography, Liquid; Humans; Ion Exchange; Mass Spectrometry; Molsidomine; Quality Control; Reproducibility of Results; Vasodilator Agents | 2000 |
4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol) inhibits peroxynitrite-mediated phenol nitration.
Topics: Animals; Antioxidants; Cyclic N-Oxides; Hydrogen-Ion Concentration; Hydroxylation; L-Lactate Dehydrogenase; Molsidomine; Nitrates; Nitro Compounds; Nitroso Compounds; PC12 Cells; Phenol; Rats; Spin Labels | 2000 |
KRN2391: dual action on rat pulmonary artery and no loss of potency in pulmonary hypertension.
Topics: Adenosine Triphosphate; Animals; Cromakalim; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Humans; Hypertension, Pulmonary; Hypoglycemic Agents; In Vitro Techniques; Infant, Newborn; Male; Methylene Blue; Molsidomine; Nitric Oxide Donors; Potassium Channels; Pulmonary Artery; Pyridines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 2000 |
NO(+) but not NO radical relaxes airway smooth muscle via cGMP-independent release of internal Ca(2+).
Topics: 4-Aminopyridine; Animals; Bronchi; Calcium; Calcium-Transporting ATPases; Charybdotoxin; Cyclic GMP; Dithiothreitol; Dogs; Enzyme Activation; Free Radicals; Guanylate Cyclase; Humans; In Vitro Techniques; Molsidomine; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Oxidation-Reduction; Penicillamine; Potassium Channels; Potassium Chloride; Tetraethylammonium; Trachea | 2000 |
Carbon dioxide enhances nitration of surfactant protein A by activated alveolar macrophages.
Topics: Carbon Dioxide; Cells, Cultured; Enzyme Activation; Epithelial Cells; Humans; Hypercapnia; Lipid Metabolism; Lipopolysaccharides; Macrophages, Alveolar; Mass Spectrometry; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Respiratory Distress Syndrome; Tyrosine | 2000 |
Critical temporal modulation of neuronal programmed cell injury.
Topics: Animals; Annexin A5; Apoptosis; Biomarkers; Cell Membrane; Cell Survival; DNA Fragmentation; Hippocampus; Molsidomine; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Phosphatidylserines; Piperidines; Rats; Rats, Sprague-Dawley; Thiazoles; Vasodilator Agents | 2000 |
Synergistic depletion of astrocytic glutathione by glucose deprivation and peroxynitrite: correlation with mitochondrial dysfunction and subsequent cell death.
Topics: Animals; Astrocytes; Cell Survival; Drug Synergism; Glucose; Glutathione; Membrane Potentials; Mitochondria; Molsidomine; Nitrates; Nitric Oxide Donors; Nitroso Compounds; Penicillamine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione | 2000 |
Heme oxygenase-1 is a cGMP-inducible endothelial protein and mediates the cytoprotective action of nitric oxide.
Topics: Animals; Cattle; Cell Survival; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Induction; Heme Oxygenase (Decyclizing); Molsidomine; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Pulmonary Artery; Second Messenger Systems | 2000 |
Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA.
Topics: Antioxidants; Bepridil; Biphenyl Compounds; Catechin; Comet Assay; DNA; DNA Damage; Flavanones; Flavonoids; Free Radical Scavengers; Genistein; Hesperidin; Humans; Indicators and Reagents; Isoflavones; Jurkat Cells; Molsidomine; Nitric Oxide Donors; Oxidation-Reduction; Picrates; Quercetin | 2000 |
Programmed cell death in 2',3'-dideoxycytidine-resistant human monoblastoid U937 cells.
Topics: Anti-HIV Agents; Apoptosis; DNA; Drug Resistance; Electrophoresis, Agar Gel; Enzyme Inhibitors; Glutathione; Humans; Molsidomine; Nitric Oxide Donors; Okadaic Acid; Phosphoprotein Phosphatases; Protein Kinase Inhibitors; Staurosporine; U937 Cells; Zalcitabine | 2000 |
The Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: involvement of its flavonoid constituents and protein kinase C.
Topics: Alkaloids; Alzheimer Disease; Animals; Antioxidants; Azoles; Benzophenanthridines; Brain Ischemia; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Diterpenes; Enzyme Inhibitors; Estrenes; Flavonoids; Free Radical Scavengers; Ginkgo biloba; Ginkgolides; Hippocampus; Isoindoles; Lactones; Molsidomine; Neurons; Neuroprotective Agents; Nitrendipine; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Organoselenium Compounds; Oxidative Stress; Phenanthridines; Phosphodiesterase Inhibitors; Plant Extracts; Plants, Medicinal; Protein Kinase C; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Signal Transduction; Vasodilator Agents | 2000 |
Influence of SIN-1 on platelet Ca2+ handling in patients with suspected coronary artery disease: ex vivo and in vitro studies.
Topics: Angina Pectoris; Aspirin; Biological Transport; Blood Platelets; Calcium; Calcium Signaling; Catalase; Coronary Angiography; Female; Humans; Injections, Intravenous; Male; Middle Aged; Molsidomine; Nitric Oxide Donors; Platelet Aggregation Inhibitors; Superoxide Dismutase; Superoxides; Thapsigargin; Thrombin | 2000 |
Two distinct mechanisms of nitric oxide-mediated neuronal cell death show thiol dependency.
Topics: Acetylcysteine; Animals; Cell Death; Cell Differentiation; Cell Line; Cell Survival; Cyclic GMP; Hydrazines; Molsidomine; Necrosis; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidants; Sulfhydryl Compounds | 2000 |
Contribution of adenoviral-mediated superoxide dismutase gene transfer to the reduction in nitric oxide-induced cytotoxicity on human islets and INS-1 insulin-secreting cells.
Topics: Adenoviridae; Animals; Cell Survival; Cells, Cultured; Genetic Vectors; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Rats; Superoxide Dismutase; Transfection; Tumor Cells, Cultured | 2000 |
Carbon dioxide but not bicarbonate inhibits N-nitrosation of secondary amines. Evidence for amine carbamates as protecting entities.
Topics: Bicarbonates; Carbamates; Carbon Dioxide; Hydrazines; Molsidomine; Morpholines; Nitric Oxide; Nitrosation | 2000 |
The origin of dinitrosyl-iron complex in endothelial cells.
Topics: Animals; Cells, Cultured; Endothelium, Vascular; Iron; Molsidomine; Nitric Oxide Donors; Nitrogen Oxides; Penicillamine | 2000 |
Citrulline does not relax isolated rat and rabbit vessels.
Topics: Animals; Aorta, Thoracic; Arginine; Carotid Arteries; Citrulline; Dose-Response Relationship, Drug; Female; Femoral Artery; In Vitro Techniques; Male; Molsidomine; Nitric Oxide Donors; Norepinephrine; Rabbits; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2000 |
Apocynin inhibits peroxynitrite formation by murine macrophages.
Topics: Acetophenones; Acridines; Animals; Antioxidants; Cell Line; Cyclic N-Oxides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanidines; Interferon-gamma; Lipopolysaccharides; Luminescent Measurements; Macrophages; Mice; Molsidomine; Nitrates; Nitric Oxide Synthase; Oxidation-Reduction; Rhodamines | 2000 |
3-Morpholinosydnonimine (SIN-1) and K(+) channels in smooth muscle cells of the rabbit and guinea pig carotid arteries.
Topics: Animals; Calcium; Guinea Pigs; In Vitro Techniques; Male; Microelectrodes; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Patch-Clamp Techniques; Potassium Channels; Rabbits; Species Specificity | 2000 |
Nitric oxide inhibits prostanoid synthesis in the rat oviduct.
Topics: Animals; Arachidonic Acid; Carbon Radioisotopes; Fallopian Tubes; Female; In Vitro Techniques; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitrogen Oxides; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Wistar; Spermine | 2000 |
Protective effect of bradykinin against glutamate neurotoxicity in cultured rat retinal neurons.
Topics: Adrenergic beta-Antagonists; Animals; Bradykinin; Bradykinin Receptor Antagonists; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Glutamic Acid; Ionomycin; Molsidomine; Neurons; Neuroprotective Agents; Nitroprusside; Rats; Rats, Wistar; Receptor, Bradykinin B2; Receptors, Bradykinin; Retina; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2000 |
The effect of nitrogen oxide level modulation on the content of thiol compounds and anaerobic sulfur metabolism in mice brains.
Topics: Anaerobiosis; Animals; Brain; Brain Chemistry; Cystathionine gamma-Lyase; Cysteine; Enzyme Inhibitors; Glutathione; Guanidines; Lipid Peroxidation; Male; Mice; Mice, Inbred CBA; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitroso Compounds; Reactive Oxygen Species; Sulfhydryl Compounds; Sulfur Compounds; Sulfurtransferases; Thiosulfate Sulfurtransferase | 1999 |
Major potassium conductance in type I hair cells from rat semicircular canals: characterization and modulation by nitric oxide.
Topics: 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic GMP; Gluconates; Guanylate Cyclase; Hair Cells, Vestibular; Membrane Potentials; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Patch-Clamp Techniques; Penicillamine; Potassium; Potassium Channel Blockers; Rats; Rats, Long-Evans; Semicircular Canals; Signal Transduction | 2000 |
Ferritin oxidation in vitro: implication of iron release and degradation by the 20S proteasome.
Topics: Cysteine Endopeptidases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Ferritins; Humans; Hydrazines; Hydrogen Peroxide; Iron; Kinetics; Molsidomine; Multienzyme Complexes; Nitric Oxide Donors; Nitrogen Oxides; Oxygen; Proteasome Endopeptidase Complex; Xanthine Oxidase | 2000 |
A common pathway for nitric oxide release from NO-aspirin and glyceryl trinitrate.
Topics: Animals; Aspirin; Cell Line; Cyclic GMP; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Epithelial Cells; Free Radical Scavengers; Imidazoles; Kidney; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Protein Binding; Swine | 2000 |
Endothelium-dependent relaxation of small resistance vessels is impaired in patients with autosomal dominant polycystic kidney disease.
Topics: Acetylcholine; Adult; Arginine; Blood Vessels; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Male; Microcirculation; Middle Aged; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Polycystic Kidney, Autosomal Dominant; Reference Values; Skin; Vascular Resistance; Vasodilation | 2000 |
Determination of NO with a Clark-type electrode.
Topics: Animals; Calibration; Electrodes; Indicators and Reagents; Microchemistry; Microcomputers; Molsidomine; Nitric Oxide; Nitric Oxide Donors | 1998 |
Simultaneous measurement of mitochondrial function and NO.
Topics: Animals; Brain; Calibration; Cell Fractionation; Centrifugation, Density Gradient; Electrochemistry; Female; Mitochondria; Molsidomine; NAD; Nitric Oxide; Nitric Oxide Donors; Oxygen; Oxygen Consumption; Rats; Rats, Wistar; Sensitivity and Specificity; Submitochondrial Particles | 1998 |
Methods for the study of NO-induced apoptosis in cultured cells.
Topics: Acridine Orange; Animals; Apoptosis; Cell Culture Techniques; Cells, Cultured; Chromatin; Chromatography, Affinity; DNA; Electrophoresis, Agar Gel; Glutathione; Indicators and Reagents; Microscopy, Electron; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; S-Nitrosoglutathione; Tumor Cells, Cultured | 1998 |
S-nitroso-N-acetylpenicillamine and nitroprusside induce apoptosis in a neuronal cell line by the production of different reactive molecules.
Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Catalase; Deferoxamine; Flow Cytometry; Hydrogen Peroxide; Molsidomine; Neuroblastoma; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Superoxide Dismutase; Tumor Cells, Cultured | 2000 |
Nitric oxide modulates mechanical strain-induced activation of p38 MAPK in mesangial cells.
Topics: Animals; Biological Transport; Cells, Cultured; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Fluorescent Antibody Technique; Glomerular Mesangium; Imidazoles; Mitogen-Activated Protein Kinases; Molsidomine; Nitric Oxide; Nitric Oxide Donors; p38 Mitogen-Activated Protein Kinases; Penicillamine; Pyridines; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Stress, Mechanical | 2000 |
Nitric oxide-induced cGMP accumulation in the mouse bladder is not related to smooth muscle relaxation.
Topics: Animals; Arginine; Carbachol; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; In Vitro Techniques; Mice; Mice, Inbred BALB C; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Phosphodiesterase Inhibitors; Piperazines; Piperidines; Purines; Quinazolines; Sildenafil Citrate; Sulfones; Urethra; Urinary Bladder | 2000 |
Evidence against a role of inducible nitric oxide synthase in the endothelial protective effects of delayed preconditioning.
Topics: Acetylcholine; Amidines; Animals; Benzylamines; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Ischemic Preconditioning, Myocardial; Male; Molsidomine; Myocardial Ischemia; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Serotonin; Vasoconstriction; Vasodilation; Vasodilator Agents | 2000 |
The mechanism of nitric oxide and/or superoxide cytotoxicity in endothelial cells.
Topics: Animals; Catalase; Cattle; Cell Death; Cells, Cultured; Endothelium, Vascular; Glutathione; Hemoglobins; Hydrogen Peroxide; Maleates; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Pyrogallol; Sulfhydryl Compounds; Superoxide Dismutase; Superoxides | 2000 |
Vasodilator effects of KRN2391, levcromakalim and 3-morpholino-sydnonimin in human pial and omental arteries.
Topics: Aged; Arteries; ATP-Binding Cassette Transporters; Cromakalim; Enzyme Inhibitors; Guanylate Cyclase; Humans; In Vitro Techniques; KATP Channels; Middle Aged; Molsidomine; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Omentum; Pia Mater; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyridines; Regional Blood Flow; Vasodilator Agents | 2000 |
Phenolic acids protect low density lipoproteins from peroxynitrite-mediated modification in vitro.
Topics: Caffeic Acids; Coumaric Acids; Humans; Kinetics; Lipoproteins, LDL; Molsidomine; Nitrates; Nitric Oxide Donors; Oxidants; Vitamin E | 2000 |
Nitric oxide and peroxynitrite anion modulate liver plasma membrane fluidity and Na(+)/K(+)-ATPase activity.
Topics: Animals; Cell Fractionation; Cell Polarity; Enzyme Activation; Fluorescence Polarization; Liver; Male; Membrane Fluidity; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase | 2000 |
Effects of peroxynitrite on rabbit cornea.
Topics: Animals; Anterior Chamber; Corneal Edema; Endothelium, Corneal; Injections; Microscopy, Electron, Scanning; Mitochondria; Molsidomine; Nitrates; Nitric Oxide Donors; Rabbits; Superoxides; Ultrasonography | 2000 |
Potentiation of carbachol-induced Ca2+ release by peroxynitrite in human neuroblastoma SH-SY5Y cells.
Topics: Calcium; Carbachol; Genistein; Humans; Molsidomine; Neuroblastoma; Nitrates; Phosphorylation; Tumor Cells, Cultured; Tyrosine | 2000 |
In vivo mechanisms of acetylcholine-induced vasodilation in rat sciatic nerve.
Topics: Acetylcholine; Analysis of Variance; Animals; Biological Factors; Blood Flow Velocity; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Guanylate Cyclase; Laser-Doppler Flowmetry; Male; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Sciatic Nerve; Tetrodotoxin; Vasodilation; Vasodilator Agents | 2000 |
Prevention of nitric oxide-induced neuronal injury through the modulation of independent pathways of programmed cell death.
Topics: Animals; Apoptosis; Cysteine Endopeptidases; Hippocampus; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Sprague-Dawley; Signal Transduction; Triazenes | 2000 |
Mechanism underlying anti-apoptotic activity of a (-)deprenyl-related propargylamine, rasagiline.
Topics: Animals; Apoptosis; Humans; Indans; Molecular Structure; Molsidomine; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Pargyline; Propylamines; Rats; Rats, Inbred F344; Selegiline; Tumor Cells, Cultured | 2000 |
Cyclooxygenase-derived products, rather than nitric oxide, are endothelium-derived relaxing factor(s) in the ventral aorta of carp (Cyprinus carpio).
Topics: Acetylcholine; Animals; Aorta; Calcimycin; Carps; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Ionophores; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Phenylephrine; Rats; Rats, Wistar; Vasodilator Agents | 2000 |
Adaptive responses to peroxynitrite: increased glutathione levels and cystine uptake in vascular cells.
Topics: Adaptation, Physiological; Animals; Cattle; Cells, Cultured; Cystine; Dose-Response Relationship, Drug; Endothelium, Vascular; Free Radical Scavengers; Glutamic Acid; Glutathione; Metalloporphyrins; Molsidomine; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide Donors; Nucleic Acid Synthesis Inhibitors; Penicillamine; Protein Synthesis Inhibitors; S-Nitroso-N-Acetylpenicillamine; Sodium; Superoxide Dismutase | 2000 |
cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation.
Topics: Animals; Cyclic GMP; Diethylamines; Drug Combinations; Enzyme Inhibitors; Glutathione; In Vitro Techniques; Male; Molsidomine; Myocardial Contraction; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nucleotides, Cyclic; Oxadiazoles; Oxidation-Reduction; Quinoxalines; Rats; Rats, Wistar; Superoxide Dismutase | 2000 |
Nitric oxide donors and angiotensin-converting enzyme inhibitors act in concert to inhibit human angiotensin-converting enzyme activity and platelet aggregation in vitro.
Topics: Angiotensin-Converting Enzyme Inhibitors; Captopril; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Enalaprilat; Endothelium, Vascular; Female; Humans; Molsidomine; Nitric Oxide Donors; Penicillamine; Peptidyl-Dipeptidase A; Platelet Aggregation; S-Nitroso-N-Acetylpenicillamine; Umbilical Veins | 2000 |
Guanylate cyclase and not ATP-dependent K(+) channels seems temperature-dependent in smooth muscle relaxation of human umbilical arteries.
Topics: Adenosine Triphosphate; Arginine; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Guanylate Cyclase; Humans; In Vitro Techniques; Molsidomine; Muscle, Smooth, Vascular; Nicorandil; Nitroarginine; Oxadiazoles; Potassium Channels; Pregnancy; Quinoxalines; Serotonin; Temperature; Umbilical Arteries; Vasodilation; Vasodilator Agents | 2000 |
Role of cGMP-inhibited phosphodiesterase and sarcoplasmic calcium in mediating the increase in basal heart rate with nitric oxide donors.
Topics: Animals; Calcium; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Heart Atria; Heart Rate; Hydrazines; Indoles; Isoquinolines; Male; Milrinone; Models, Biological; Molsidomine; Nitric Oxide Donors; Nitrogen Oxides; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Aggregation Inhibitors; Pyrroles; Quinazolines; Ryanodine; Sarcoplasmic Reticulum; Signal Transduction; Spectrometry, Fluorescence; Sulfonamides; Superoxide Dismutase; Tetrahydroisoquinolines; Thionucleotides; Time Factors; Vasodilator Agents | 2000 |
NO-induced modulation of calcium-oscillations in pulmonary vascular smooth muscle.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphate; Animals; Caffeine; Calcium; Cyclic GMP-Dependent Protein Kinases; Endothelin-1; Indoles; Isometric Contraction; Male; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Penicillamine; Pulmonary Artery; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Sarcoplasmic Reticulum; Vasodilation; Vasodilator Agents | 2000 |
Nitric oxide inhibits isoproterenol-stimulated adipocyte lipolysis through oxidative inactivation of the beta-agonist.
Topics: 3T3 Cells; Adipocytes; Animals; Catecholamines; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Hydrazines; Indolequinones; Indoles; Isoproterenol; Lipolysis; Mice; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxygen; Rats; Rats, Wistar; Signal Transduction; Spectrophotometry; Time Factors; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 2000 |
Analysis of 3-morpholinosydnonimine and sodium nitroprusside effects on dopamine release in the striatum of freely moving rats: role of nitric oxide, iron and ascorbic acid.
Topics: Animals; Ascorbic Acid; Corpus Striatum; Deferoxamine; Dopamine; Iron; Male; Microdialysis; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Rats; Rats, Wistar | 2000 |
Metallothionein inhibits peroxynitrite-induced DNA and lipoprotein damage.
Topics: Antioxidants; Cell-Free System; DNA Damage; Dose-Response Relationship, Drug; Lipid Peroxides; Lipoproteins; Lipoproteins, LDL; Metallothionein; Molsidomine; Nitrates; Nitrogen; Oxygen; Plasmids; Temperature; Thiobarbituric Acid Reactive Substances; Time Factors | 2000 |
Various nitric oxide donors protect chick embryonic neurons from cyanide-induced apoptosis.
Topics: Animals; Apoptosis; Cell Death; Cells, Cultured; Chick Embryo; Dithiothreitol; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutathione; Hydrazines; Kynurenic Acid; Molsidomine; Neurons; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitrogen Oxides; Nitroglycerin; Nitroprusside; Nitroso Compounds; Penicillamine; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Sodium Cyanide | 2000 |
Modulatory effects of nitric oxide on synaptic depression in the crayfish neuromuscular system.
Topics: Animals; Arginine; Astacoidea; Benzoates; Enzyme Inhibitors; Female; Glutamic Acid; Hydrazines; Imidazoles; Male; Molsidomine; Motor Neurons; Neuromuscular Junction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Superoxide Dismutase; Synaptic Transmission | 2000 |
Nitric oxide inhibits Marek's disease virus replication but is not the single decisive factor in interferon-gamma-mediated viral inhibition.
Topics: Animals; Bone Marrow Cells; Cells, Cultured; Chick Embryo; Chickens; Chlorocebus aethiops; Coculture Techniques; COS Cells; Fibroblasts; Herpesvirus 2, Gallid; Interferon-gamma; Macrophages; Molsidomine; Nitric Oxide; Nitric Oxide Donors; omega-N-Methylarginine; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Superoxide Dismutase; Superoxides; Virus Replication | 2000 |
Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts.
Topics: Androstadienes; Apoptosis; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Molsidomine; Morpholines; Nitrates; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Skin; Time Factors; Tyrosine; Tyrphostins; Wortmannin | 2000 |
Effects of propofol on endothelial cells subjected to a peroxynitrite donor (SIN-1).
Topics: Anesthetics, Intravenous; Cell Culture Techniques; Cell Death; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Molsidomine; Nitrates; Nitric Oxide Donors; Propofol; Tyrosine | 2000 |
Peroxynitrite formation and decreased catalase activity in autoimmune MRL-lpr/lpr mice.
Topics: Animals; Arthritis; Autoimmune Diseases; Catalase; Cattle; DNA Damage; Glomerulonephritis; Immunoblotting; Kidney; Liver; Mice; Mice, Inbred MRL lpr; Mice, Knockout; Molsidomine; Nitrates; Nitric Oxide Donors; omega-N-Methylarginine; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase | 2000 |
Nitration and inactivation of cytochrome P450BM-3 by peroxynitrite. Stopped-flow measurements prove ferryl intermediates.
Topics: Animals; Bacillus; Bacterial Proteins; Binding Sites; Blotting, Western; Cattle; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dithiothreitol; Dose-Response Relationship, Drug; Erythrocytes; Glutathione; Inhibitory Concentration 50; Iron; Mass Spectrometry; Mixed Function Oxygenases; Models, Chemical; Models, Molecular; Molsidomine; NADPH-Ferrihemoprotein Reductase; Nitrates; Nitric Oxide Donors; Nitrogen; Oxygen; Superoxide Dismutase; Temperature; Time Factors; Tyrosine; Uric Acid | 2000 |
Nitric oxide activation of TrkB through peroxynitrite.
Topics: 3T3 Cells; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Humans; Indole Alkaloids; Isoenzymes; Mice; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidants; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Rats; Receptor, trkB; Recombinant Proteins; Superoxide Dismutase; Transfection; Type C Phospholipases | 2000 |
Prior heat stress improves survival of ischemic-reperfused skeletal muscle in vivo.
Topics: Animals; Cell Survival; Cells, Cultured; Clone Cells; Heat-Shock Response; Hot Temperature; HSP70 Heat-Shock Proteins; Humans; Hydrogen Peroxide; Ischemia; Male; Molsidomine; Muscle, Skeletal; Nitric Oxide Donors; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Reperfusion; Reperfusion Injury; Transfection | 2000 |
Augmented death in immunostimulated astrocytes deprived of glucose: inhibition by an iron porphyrin FeTMPyP.
Topics: Animals; Astrocytes; Cell Death; Ferric Compounds; Glucose; Interferon-gamma; Membrane Potentials; Metalloporphyrins; Mitochondria; Molsidomine; Nitrates; Porphyrins; Rats; Rats, Sprague-Dawley | 2001 |
Nitric oxide limits pressor responses to sympathetic activation in rat spinal cord.
Topics: Anesthesia; Animals; Arginine; Calcium; Enzyme Activation; Enzyme Inhibitors; Male; Molsidomine; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Pressoreceptors; Rats; Rats, Inbred WKY; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Sympathetic Nervous System | 2000 |
Target cell-derived superoxide anions cause efficiency and selectivity of intercellular induction of apoptosis.
Topics: Animals; Apoptosis; Cells, Cultured; Dimethyl Sulfoxide; Enzyme Inhibitors; Fibroblasts; Free Radical Scavengers; Kinetics; Molsidomine; Nitric Oxide Synthase; Nitroprusside; Rats; Superoxide Dismutase; Superoxides; Taurine; Transforming Growth Factor beta | 2000 |
Nitric oxide donor improved the impaired endothelial-dependent relaxation of canine hepatic artery after preservation with UW solution.
Topics: Acetylcholine; Adenosine; Allopurinol; Animals; Dogs; Endothelium, Vascular; Glutathione; Hepatic Artery; Insulin; Molsidomine; Muscle Relaxation; Nitric Oxide Donors; Norepinephrine; Organ Preservation; Organ Preservation Solutions; Potassium; Raffinose; Vasodilation | 2000 |
A novel procedure for generating both nitric oxide and superoxide in situ from chemical sources at any chosen mole ratio. First application: tyrosine oxidation and a comparison with preformed peroxynitrite.
Topics: Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxidants; Oxidation-Reduction; Spermine; Superoxides; Tyrosine | 2000 |
Reactive oxygen and nitrogen metabolites modulate fibronectin-induced fibroblast migration in vitro.
Topics: Blood; Cell Line; Cell Movement; Complement Activation; Deferoxamine; Dithiothreitol; Embryo, Mammalian; Fibroblasts; Fibronectins; Humans; Lung; Molsidomine; Nitrates; Nitric Oxide Donors; Nitrogen; Reactive Oxygen Species; Reducing Agents; Superoxides; Tyrosine; Xanthine Oxidase | 2001 |
Toxicity of nitric oxide and peroxynitrite to bacterial pathogens of fish.
Topics: Aeromonas; Animals; Bacterial Infections; Catalase; Cell-Free System; Fish Diseases; Free Radical Scavengers; Microbial Sensitivity Tests; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oncorhynchus mykiss; Oxidants; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Superoxide Dismutase | 2000 |
Peroxynitrite induces GADD34, 45, and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells.
Topics: Antigens, Differentiation; Antioxidants; Apoptosis; CCAAT-Enhancer-Binding Proteins; Cell Cycle Proteins; DNA Damage; Enzyme Activation; Flow Cytometry; GADD45 Proteins; Gene Expression Regulation, Neoplastic; Glutathione; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Molsidomine; Neoplasm Proteins; Neuroblastoma; Nitrates; Oxidation-Reduction; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Proteins; Pyridines; RNA, Messenger; Signal Transduction; Transcription Factor CHOP; Transcription Factors; Tumor Cells, Cultured | 2001 |
Role of nitric oxide in the synthesis of guanidinosuccinic acid, an activator of the N-methyl-D-aspartate receptor.
Topics: Animals; Argininosuccinic Acid; Guanidine; Guanidines; Hepatocytes; In Vitro Techniques; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Succinates; Urea | 2001 |
Regulation of neuronal growth cone filopodia by nitric oxide depends on soluble guanylyl cyclase.
Topics: Animals; Cells, Cultured; Cyclic GMP; Ganglia, Invertebrate; Growth Cones; Guanylate Cyclase; Molsidomine; NADPH Dehydrogenase; Nervous System; Nitric Oxide; Nitric Oxide Donors; Potassium Chloride; Snails | 2001 |
Inhibition of nerve growth factor signaling by peroxynitrite.
Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Cell Survival; Dose-Response Relationship, Drug; Humans; MAP Kinase Signaling System; Molsidomine; Nerve Growth Factor; Neurons; Nitrates; Nitric Oxide Donors; Oxidative Stress; PC12 Cells; Rats; Receptor, trkA | 2001 |
Mechanisms of nitric oxide-induced cytotoxicity in normal human hepatocytes.
Topics: Adult; Apoptosis; Blotting, Southern; Cell Cycle; Cell Division; Cell Survival; Cells, Cultured; DNA Damage; DNA, Mitochondrial; Dose-Response Relationship, Drug; Electron Transport; Hepatocytes; Humans; Hypoxanthine Phosphoribosyltransferase; Molsidomine; Mutagenicity Tests; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Reactive Oxygen Species | 2001 |
Effects of endogenous nitric oxide in activation of group IV muscle afferents.
Topics: Animals; Blood Pressure; Electric Stimulation; Enzyme Inhibitors; In Vitro Techniques; Molsidomine; Muscle Contraction; Muscle, Skeletal; Neurons, Afferent; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rabbits | 2001 |
Nitric oxide up-regulates DNA-binding activity of nuclear factor-kappaB in macrophages stimulated with silica and inflammatory stimulants.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Cell Line; Cell Nucleus; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Isoquinolines; Lipopolysaccharides; Lysine; Macrophages; Macrophages, Alveolar; Male; Mice; Molsidomine; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitroprusside; Phagocytosis; Protein Binding; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Silicon Dioxide; Staurosporine; Sulfonamides; Tyrphostins; Up-Regulation | 2000 |
Characterization of peroxynitrite-oxidized low density lipoprotein binding to human CD36.
Topics: Animals; Arteriosclerosis; CD36 Antigens; CHO Cells; Copper; Cricetinae; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Humans; Lipid Peroxides; Lipoproteins, LDL; Membrane Proteins; Molsidomine; Nitrates; Oxidation-Reduction; Plasmodium falciparum; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, Scavenger; Scavenger Receptors, Class B; Thiobarbituric Acid Reactive Substances; Transfection | 2001 |
Coenzyme Q10, vitamin E, and dihydrothioctic acid cooperatively prevent diene conjugation in isolated low-density lipoprotein.
Topics: Antioxidants; Ascorbic Acid; Coenzymes; Copper; Humans; Ions; Lipoproteins, LDL; Male; Middle Aged; Models, Biological; Molsidomine; Nitric Oxide Donors; Oxygen; Protein Binding; Thioctic Acid; Time Factors; Ubiquinone; Vitamin E | 2000 |
Superoxide dismutase activity in organotypic midbrain-striatum co-cultures is associated with resistance of dopaminergic neurons to excitotoxicity.
Topics: Animals; Animals, Newborn; Cell Survival; Coculture Techniques; Corpus Striatum; Dihydrolipoamide Dehydrogenase; Dopamine; Mesencephalon; Molsidomine; N-Methylaspartate; Neurons; Neurotoxins; Nitric Oxide Donors; Nitroarginine; Nitroso Compounds; Organ Culture Techniques; Rats; Rats, Wistar; Superoxide Dismutase; Tyrosine; Tyrosine 3-Monooxygenase | 2001 |
Nitric oxide in the afferent synaptic transmission of the axolotl vestibular system.
Topics: Action Potentials; Ambystoma; Animals; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Hair Cells, Vestibular; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Acid; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Synapses; Synaptic Transmission | 2001 |
Chemical evaluation of compounds as nitric oxide or peroxynitrite donors using the reactions with serotonin.
Topics: Aerobiosis; Chromatography, High Pressure Liquid; Copper; Glutathione; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Nitroprusside; Nitroso Compounds; Oxidants; Oxidation-Reduction; S-Nitrosoglutathione; Serotonin; Tyrosine | 2001 |
Protective effects of morphine in peroxynitrite-induced apoptosis of primary rat neonatal astrocytes: potential involvement of G protein and phosphatidylinositol 3-kinase (PI3 kinase).
Topics: Animals; Apoptosis; Astrocytes; Cell Survival; Cells, Cultured; Chromatin; DNA Fragmentation; Drug Interactions; Female; Glutathione; GTP-Binding Proteins; Molsidomine; Morphine; Naloxone; Narcotic Antagonists; Nitrates; Nitric Oxide Donors; Oxidants; Phosphatidylinositol 3-Kinases; Protective Agents; Rats; Rats, Sprague-Dawley | 2001 |
Cytotoxic effects of peroxynitrite, polymorphonuclear neutrophils, free-radical scavengers, inhibitors of myeloperoxidase, and inhibitors of nitric oxide synthase on bovine mammary secretory epithelial cells.
Topics: Aniline Compounds; Animals; Antioxidants; Blotting, Western; Cattle; Cell Death; Enzyme Inhibitors; Epithelial Cells; Female; Free Radical Scavengers; Histidine; L-Lactate Dehydrogenase; Lipopolysaccharides; Mammary Glands, Animal; Molsidomine; Neutrophil Activation; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxidants; Peroxidase; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tyrosine | 2001 |
Classes of thiols that influence the activity of the skeletal muscle calcium release channel.
Topics: Animals; Glutathione; Glutathione Disulfide; Kinetics; Molsidomine; Muscle, Skeletal; Nitric Oxide; Nitric Oxide Donors; Oxidation-Reduction; Protein Subunits; Rabbits; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Sulfhydryl Compounds; Superoxides | 2001 |
Response of neonatal platelets to nitric oxide in vitro.
Topics: Adult; Age Factors; Blood Platelets; Case-Control Studies; Female; Fetal Blood; Humans; In Vitro Techniques; Infant, Newborn; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Platelet Glycoprotein GPIIb-IIIa Complex | 2001 |
The dual effect of a nitric oxide donor in nociception.
Topics: Animals; Chronic Disease; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hemoglobins; Injections, Spinal; Ligation; Male; Molsidomine; Nerve Compression Syndromes; Neuralgia; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Sciatic Nerve | 2001 |
Inhibition of nitric oxide synthase activity reduces liver injury in murine schistosomiasis.
Topics: Animals; Arginine; Enzyme Inhibitors; Female; Hydroxyproline; Lipid Peroxides; Liver; Liver Cirrhosis; Lung; Mice; Mice, Inbred CBA; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Parasite Egg Count; Rodent Diseases; Schistosomiasis | 2001 |
Evidence that nitric oxide-induced synthesis of cGMP occurs in a paracrine but not an autocrine fashion and that the site of its release can be regulated: studies in dorsal root ganglia in vivo and in vitro.
Topics: Animals; Animals, Newborn; Autocrine Communication; Axotomy; Bradykinin; Capsaicin; Carbon-Nitrogen Ligases; Cells, Cultured; Cyclic GMP; Female; Ganglia, Spinal; Immunohistochemistry; Male; Molsidomine; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oligodendroglia; Paracrine Communication; Rats; Rats, Wistar; Sciatic Nerve | 2001 |
SIN-1-induced DNA damage in isolated human peripheral blood lymphocytes as assessed by single cell gel electrophoresis (comet assay).
Topics: Ascorbic Acid; Calcium; Catalase; Chelating Agents; Comet Assay; Data Interpretation, Statistical; DNA Damage; DNA, Single-Stranded; Dose-Response Relationship, Drug; Egtazic Acid; Flow Cytometry; Humans; Kinetics; Lymphocytes; Microscopy, Ultraviolet; Molsidomine; Nitrates; Nitric Oxide Donors; Superoxide Dismutase | 2001 |
Nitric oxide reduces energy supply by direct action on the respiratory chain in isolated cardiomyocytes.
Topics: Adenosine; Alkaloids; Animals; Calcium; Carbazoles; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Electron Transport; Energy Metabolism; Enzyme Inhibitors; Indoles; Molsidomine; Muscle Fibers, Skeletal; Myocardium; NAD; Nitric Oxide; Nitric Oxide Donors; Oxygen Consumption; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine | 2001 |
Effects of endothelin-1 and nitric oxide on proliferation of cultured guinea pig bronchial smooth muscle cells.
Topics: Animals; Bronchi; Cell Division; Cells, Cultured; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; Male; Molsidomine; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Peptides, Cyclic; Quinoxalines | 2001 |
Effects of nitric oxide on normal and ischemic cochlea of the guinea pig.
Topics: Animals; Catalase; Cell Count; Cochlea; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Hair Cells, Auditory, Inner; Hair Cells, Auditory, Outer; Ischemia; Microinjections; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitrites; Nitroglycerin; Nitroso Compounds; Perilymph; S-Nitrosothiols; Sensory Receptor Cells; Superoxide Dismutase | 2001 |
SIN-1, a nitric oxide donor, ameliorates experimental allergic encephalomyelitis in Lewis rats in the incipient phase: the importance of the time window.
Topics: Adjuvants, Immunologic; Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; B7-1 Antigen; B7-2 Antigen; Cell Membrane; Cell Movement; Down-Regulation; Drug Administration Schedule; Encephalomyelitis, Autoimmune, Experimental; Guinea Pigs; Histocompatibility Antigens Class II; Immunosuppressive Agents; Injections, Intraperitoneal; Interferon-gamma; Leukocyte Count; Leukocytes, Mononuclear; Lymphocyte Activation; Membrane Glycoproteins; Molecular Sequence Data; Molsidomine; Myelin Basic Protein; Nitric Oxide; Nitric Oxide Donors; Peptide Fragments; Rats; Rats, Inbred Lew; Spinal Cord | 2001 |
A redox-based mechanism for the contractile and relaxing effects of NO in the guinea-pig gall bladder.
Topics: Acetylcholine; Animals; Arachidonic Acid; Atropine; Calcium; Gallbladder; Guinea Pigs; Male; Molsidomine; Muscle Contraction; Muscle, Smooth; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxidants; Oxidation-Reduction; Parasympatholytics; Vasodilator Agents | 2001 |
Nitric oxide modulates cardiac performance in the heart of Anguilla anguilla.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Anguilla; Animals; Arginine; Atropine; Detergents; Enzyme Inhibitors; Female; Free Radical Scavengers; Heart; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Molsidomine; Muscarinic Antagonists; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Octoxynol; omega-N-Methylarginine; Ornithine; Oxadiazoles; Parasympatholytics; Pirenzepine; Quinoxalines; Superoxide Dismutase | 2001 |
Peroxynitrite inhibits inducible (type 2) nitric oxide synthase in murine lung epithelial cells in vitro.
Topics: Animals; Base Sequence; Cell Line; DNA Primers; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Hydrazines; Lung; Mice; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; RNA, Messenger; Tyrosine | 2001 |
Hepatocellular oxidative DNA injury induced by macrophage-derived nitric oxide.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Deoxyguanosine; DNA Damage; Enzyme Inhibitors; Free Radicals; Hepatocytes; In Vitro Techniques; Interferon-gamma; Lipopolysaccharides; Macrophages; Male; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Rats; Rats, Wistar; Recombinant Proteins; Superoxide Dismutase | 2001 |
Apolipoprotein A-I promotes the formation of phosphatidylcholine core aldehydes that are hydrolyzed by paraoxonase (PON-1) during high density lipoprotein oxidation with a peroxynitrite donor.
Topics: Aldehydes; Apolipoprotein A-I; Aryldialkylphosphatase; Electrophoresis, Polyacrylamide Gel; Esterases; Humans; Hydrolysis; Lipoproteins, HDL; Lysophosphatidylcholines; Molsidomine; Nitrates; Oxidation-Reduction; Phosphatidylcholines; Phospholipases A; Proteolipids; Trypsin | 2001 |
Rat germinal cells require PARP for repair of DNA damage induced by gamma-irradiation and H2O2 treatment.
Topics: Animals; Benzamides; Blotting, Western; Catalase; Cell Nucleus; Cells, Cultured; Comet Assay; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gamma Rays; Germ Cells; Glutathione; Hydrogen Peroxide; Male; Microscopy, Fluorescence; Molsidomine; Neuroprotective Agents; Nitric Oxide Donors; Nitroso Compounds; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; S-Nitrosoglutathione; Spermatids; Spermatocytes; Superoxide Dismutase; Time Factors | 2001 |
[Inhibition of signal transduction pathways of endothelin-1-induced proliferation of vascular smooth muscle cells by nitric oxide].
Topics: Animals; Aorta, Thoracic; Arginine; Cell Division; Cells, Cultured; Endothelin-1; Mitogen-Activated Protein Kinases; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Protein Kinase C; Rabbits; Signal Transduction | 1998 |
Influence of endothelium in dose-dependent inhibition and potentiation by isoniazid of isosorbide dinitrate relaxation of rat aorta.
Topics: Animals; Antitubercular Agents; Aorta, Thoracic; Dose-Response Relationship, Drug; Endothelium, Vascular; Isoniazid; Isosorbide Dinitrate; Male; Molsidomine; Papaverine; Rats; Rats, Wistar; Vasodilator Agents | 2001 |
NO donors inhibit Leishmania infantum cysteine proteinase activity.
Topics: Animals; Ascorbic Acid; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dithiothreitol; Glutathione; Kinetics; Leishmania infantum; Leupeptins; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Nitroglycerin; Nitroprusside; Nitroso Compounds; Penicillamine; Protozoan Proteins; S-Nitrosoglutathione | 2001 |
Nitrogen dioxide induces death in lung epithelial cells in a density-dependent manner.
Topics: Cell Count; Cell Death; Cells, Cultured; Culture Media, Conditioned; DNA, Single-Stranded; In Situ Nick-End Labeling; Lung; Molsidomine; Nitrates; Nitric Oxide Donors; Nitrites; Nitrogen Dioxide; Oxidative Stress; Respiratory Mucosa | 2001 |
Effects of nitroprusside, 3-morpholino-sydnonimine, and spermine on calcium-sensitive potassium currents in gastric antral circular myocytes of guinea pig.
Topics: Animals; Cell Separation; Female; Guinea Pigs; Male; Molsidomine; Muscle, Smooth; Nitric Oxide Donors; Nitroprusside; Patch-Clamp Techniques; Potassium Channels; Pyloric Antrum; Spermine | 2000 |
In vivo and in vitro apoptosis of human thymocytes are associated with nitrotyrosine formation.
Topics: Annexin A5; Apoptosis; Cells, Cultured; Child, Preschool; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Humans; In Situ Nick-End Labeling; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Stromal Cells; Superoxide Dismutase; Superoxides; T-Lymphocytes; Thymus Gland; Tyrosine | 2001 |
Oxidative stress promotes the development of transformation: involvement of a potent mutagenic lipid peroxidation product, acrolein.
Topics: Acrolein; Amidines; Animals; Antioxidants; Benzo(a)pyrene; Biotransformation; Cell Transformation, Neoplastic; Fibroblasts; Free Radicals; Lipid Peroxidation; Mice; Mice, Inbred C3H; Molsidomine; Mutagens; Nitrates; Nitric Oxide Donors; Oxidants; Oxidative Stress; Reactive Oxygen Species; Vitamin E | 2001 |
Light and scanning-electron microscopic examination of coronary stents in a perfusion-model. Effects of an NO-donor/quantitative analysis.
Topics: Blood Platelets; Drug Evaluation, Preclinical; Humans; Materials Testing; Microscopy, Electron; Molsidomine; Nitric Oxide Donors; Perfusion; Platelet Adhesiveness; Platelet Aggregation; Stents | 2001 |
Immunostimulation of rat primary astrocytes decreases intracellular ATP level.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Astrocytes; Central Nervous System; Dose-Response Relationship, Drug; Encephalitis; Enzyme Inhibitors; Inflammation Mediators; Interferon-gamma; Intracellular Fluid; L-Lactate Dehydrogenase; Lipopolysaccharides; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Penicillamine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Tumor Cells, Cultured | 2001 |
Two different NO-dependent mechanisms account for the low virulence of a non-mycelial morphological mutant of Candida albicans.
Topics: Animals; Candida albicans; Candidiasis; Guanidines; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Molsidomine; Mutagenesis; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Virulence | 2001 |
Anti-adrenergic effects of nitric oxide donor SIN-1 in rat cardiac myocytes.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Calcium-Binding Proteins; Enzyme Inhibitors; Free Radical Scavengers; Humans; Isoproterenol; Molsidomine; Muscle Contraction; Myocardium; Myosin Light Chains; Nitric Oxide Donors; Oxadiazoles; Phosphorylation; Rats; Superoxide Dismutase; Troponin I | 2001 |
Nitration and oxidation of a hydrophobic tyrosine probe by peroxynitrite in membranes: comparison with nitration and oxidation of tyrosine by peroxynitrite in aqueous solution.
Topics: Bicarbonates; Cyclic N-Oxides; Free Radicals; Hydroxyl Radical; Lipid Bilayers; Liposomes; Mass Spectrometry; Membranes, Artificial; Molsidomine; Nitrates; Nitrosation; Oxidation-Reduction; Solutions; Solvents; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spin Labels; Tyrosine; Water | 2001 |
Danchunhwan water extract prevents apoptotic death by peroxynitrite and nitric oxide in human dopaminergic neuroblastoma SH-SY5Y cells.
Topics: Antioxidants; Apoptosis; Caspase 3; Caspases; Dopamine; Drug Interactions; Drugs, Chinese Herbal; Glutathione; Humans; Molsidomine; Neuroblastoma; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxidative Stress; Peroxynitrous Acid; Phytotherapy; Plant Extracts; Salvia miltiorrhiza; Tumor Cells, Cultured | 2001 |
Relaxation to authentic nitric oxide and SIN-1 in rat isolated mesenteric arteries: variable role for smooth muscle hyperpolarization.
Topics: 4-Aminopyridine; Animals; Charybdotoxin; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Membrane Potentials; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Peptides; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Wistar; Vasodilation | 2001 |
Taurine is a weak scavenger of peroxynitrite and does not attenuate sodium nitroprusside toxicity to cells in culture.
Topics: Animals; Cell Death; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Free Radical Scavengers; Free Radicals; Molsidomine; Nitric Oxide Donors; Nitroprusside; PC12 Cells; Peroxynitrous Acid; Rats; Rhodamines; Taurine; Time Factors | 2001 |
NF-kappaB, inducible nitric oxide synthase and apoptosis by Helicobacter pylori infection.
Topics: Antioxidants; Apoptosis; Catalase; Cell Line; Cell Survival; Enzyme Induction; Gastric Mucosa; Gene Expression Regulation, Enzymologic; Helicobacter Infections; Helicobacter pylori; Humans; Molsidomine; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroso Compounds; Oligodeoxyribonucleotides, Antisense; Pyrrolidines; Radiation-Protective Agents; Thiazines; Thiocarbamates | 2001 |
Antiapoptotic properties of rasagiline, N-propargylamine-1(R)-aminoindan, and its optical (S)-isomer, TV1022.
Topics: Adrenergic Agents; Apoptosis; Cell Line; Humans; Indans; Molsidomine; Neuroprotective Agents; Nitric Oxide Donors; Oxidopamine; Pargyline; Propylamines; Stereoisomerism | 2001 |
Mechanism for muscarinic inhibition of I(Ca(L)) is determined by the path for elevating cyclic AMP in cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Aminoquinolines; Animals; Atrial Natriuretic Factor; Calcium Channels, L-Type; Carbachol; Cyclic AMP; Enzyme Inhibitors; Guinea Pigs; Molsidomine; Muscarinic Agonists; Myocardium; Nitric Oxide Donors; Oxadiazoles; Patch-Clamp Techniques; Second Messenger Systems | 2001 |
Effects of nitric oxide and peroxynitrite on endotoxin-induced leukocyte adhesion to endothelium.
Topics: Animals; Cattle; Cell Adhesion; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Interferon-gamma; Leukocytes; Lipopolysaccharides; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Triazenes | 2001 |
Contractility of late pregnant rat myometrium is refractory to activation of soluble but not particulate guanylate cyclase.
Topics: Animals; Atrial Natriuretic Factor; Dose-Response Relationship, Drug; Enzyme Activation; Female; Guanylate Cyclase; Hydrazines; Molsidomine; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Pregnancy; Rats; Rats, Sprague-Dawley; Solubility; Uterine Contraction | 2001 |
Induction of cyclo-oxygenase-2 in human endothelial cells by SIN-1 in the absence of prostaglandin production.
Topics: Blotting, Northern; Blotting, Western; Cell Line; Cyclooxygenase 2; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Interleukin-1; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinases; Molsidomine; Nitrates; Precipitin Tests; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyridines; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha | 2001 |
Nitric oxide modulates spontaneous cord dorsum potentials in the cat spinal cord.
Topics: Action Potentials; Animals; Cats; Enzyme Inhibitors; Molsidomine; Neural Inhibition; Neural Pathways; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Posterior Horn Cells | 2001 |
Future of neuroprotection in Parkinson's disease.
Topics: Apoptosis; Humans; Molsidomine; Neuroprotective Agents; Neurotoxins; Nitric Oxide Donors; Oxidopamine; Parkinson Disease; Propylamines; Salsoline Alkaloids; Selegiline; Tetrahydroisoquinolines; Tumor Cells, Cultured | 2001 |
Diversity of endotoxin-induced nitrotyrosine formation in macrophage-endothelium-rich organs.
Topics: Animals; Endothelium, Vascular; Immunoblotting; Immunoenzyme Techniques; Lipopolysaccharides; Liver; Lung; Macrophages; Male; Molsidomine; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peroxidase; Rats; Rats, Sprague-Dawley; Spleen; Superoxides; Tyrosine | 2001 |
Reaction of human myoglobin and peroxynitrite: characterizing biomarkers for myoglobin-derived oxidative stress.
Topics: Biomarkers; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Molsidomine; Mutagenesis, Site-Directed; Myocardial Reperfusion Injury; Myoglobin; Nitrates; Oxidative Stress; Reactive Oxygen Species | 2001 |
[Effects of nitric oxide on platelet function in burned rats].
Topics: Animals; Burns; Female; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Random Allocation; Rats; Rats, Wistar | 1999 |
Peroxynitrite causes endothelial cell monolayer barrier dysfunction.
Topics: Actins; Animals; beta Catenin; Cell Survival; Cells, Cultured; Cytoskeletal Proteins; Endothelium, Vascular; Kinetics; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidants; Pulmonary Artery; Reactive Oxygen Species; Superoxide Dismutase; Swine; Trans-Activators; Tyrosine | 2001 |
Actions of NO donors and endogenous nitrergic transmitter on the longitudinal muscle of rat ileum in vitro: mechanisms involved.
Topics: Animals; Apamin; Atropine; Calcium Channels; Charybdotoxin; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Ileum; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nifedipine; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Tetrodotoxin | 2001 |
Role of nitric oxide in histamine release from human basophils and rat peritoneal mast cells.
Topics: Animals; Antibodies; Arginine; Basophils; Calcimycin; Dose-Response Relationship, Drug; Guanidines; Hemoglobins; Histamine; Humans; Immunoglobulin E; Male; Mast Cells; Methylene Blue; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nitroprusside; p-Methoxy-N-methylphenethylamine; Peritoneal Cavity; Rats; Rats, Sprague-Dawley; Sodium Fluoride; Sodium Nitrite | 2001 |
TBC3711, an ET(A) receptor antagonist, reduces neonatal hypoxia-induced pulmonary hypertension in piglets.
Topics: Animals; Animals, Newborn; Cell Line; Endothelin Receptor Antagonists; Endothelin-1; Humans; Hypertension, Pulmonary; Hypoxia; Iodine Radioisotopes; Lung; Molsidomine; Nitric Oxide; Receptor, Endothelin A; Swine; Vasodilator Agents | 2001 |
NO-induced relaxation of labouring and non-labouring human myometrium is not mediated by cyclic GMP.
Topics: Charybdotoxin; Cyclic GMP; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Humans; In Vitro Techniques; Labor, Obstetric; Molsidomine; Muscle Relaxation; Muscle, Smooth; Myometrium; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Oxytocin; Penicillamine; Peptides; Pregnancy; Quinoxalines; S-Nitrosothiols; Scorpion Venoms; Time Factors; Uterus | 2001 |
NO donor SIN-1 potentiates monosynaptic reflexes in the cat spinal cord.
Topics: Animals; Blood Pressure; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Injections, Intravenous; Microinjections; Molsidomine; Nitric Oxide Donors; Reflex, Monosynaptic; Spinal Cord; Synapses | 2001 |
Mutagenicity of nitric oxide-releasing compounds in Escherichia coli: effect of superoxide generation and evidence for two mutagenic mechanisms.
Topics: Diethylamines; DNA Damage; Escherichia coli; Genes, Bacterial; Genes, Suppressor; Models, Genetic; Molsidomine; Mutagenicity Tests; Mutagens; Naphthoquinones; Nitric Oxide Donors; Spermine; Superoxides | 2001 |
Genetic augmentation of nitric oxide synthase increases the vascular generation of VEGF.
Topics: Analysis of Variance; Animals; Cells, Cultured; DEET; Endothelial Growth Factors; Humans; Lymphokines; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Penicillamine; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Differential modulation of prostaglandin H synthase-2 by nitric oxide-related species in intact cells.
Topics: Animals; Astrocytes; Brain; Cells, Cultured; Chlorocebus aethiops; COS Cells; Cyclooxygenase 2; Dinoprostone; Gene Expression Regulation, Enzymologic; Isoenzymes; Lipopolysaccharides; Mice; Molsidomine; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroso Compounds; Oxidation-Reduction; Penicillamine; Prostaglandin-Endoperoxide Synthases; S-Nitroso-N-Acetylpenicillamine; Transfection | 2001 |
Inhibition of acetylcholine synthesis and tyrosine nitration induced by peroxynitrite are differentially prevented by antioxidants.
Topics: Acetates; Acetylcholine; Animals; Antioxidants; Biological Transport; Carbon Radioisotopes; Choline; Choline O-Acetyltransferase; Drug Interactions; Molsidomine; Nitrates; Oxidants; Reducing Agents; Torpedo; Tyrosine; Uric Acid | 2001 |
A study on the role of nitric oxide and iron in 3-morpholino-sydnonimine-induced increases in dopamine release in the striatum of freely moving rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Animals; Ascorbic Acid; Corpus Striatum; Deferoxamine; Dialysis Solutions; Dopamine; Dose-Response Relationship, Drug; Free Radical Scavengers; Homovanillic Acid; Iron; Male; Metalloporphyrins; Molsidomine; Movement; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Wistar; Uric Acid | 2001 |
Killing of lymphoblastic leukemia cells by nitric oxide and taxol: involvement of NF-kappaB activity.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Survival; Cytoskeleton; Drug Synergism; Humans; Leukemia L1210; Leukemia, Lymphoid; Mice; Molsidomine; NF-kappa B; Nitric Oxide; Nitric Oxide Donors; Paclitaxel; Penicillamine; Protein Synthesis Inhibitors; Pyrrolidines; Thiocarbamates; Tumor Cells, Cultured | 2001 |
Shear stress-induced nitric oxide release triggers the liver regeneration cascade.
Topics: Animals; Biopsy; Blotting, Northern; Enzyme Inhibitors; Hepatectomy; In Vitro Techniques; Liver; Liver Regeneration; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Portal Vein; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stress, Physiological | 2001 |
Comparative impacts of glutathione peroxidase-1 gene knockout on oxidative stress induced by reactive oxygen and nitrogen species in mouse hepatocytes.
Topics: Animals; Cell Survival; Cells, Cultured; Diquat; DNA Fragmentation; Drug Interactions; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Hepatocytes; Herbicides; Mice; Mice, Knockout; Molsidomine; Nitric Oxide Donors; Nitrogen; Oxidative Stress; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine; Superoxide Dismutase | 2001 |
S-nitrosothiols do not induce oxidative stress, contrary to other nitric oxide donors, in cultures of vascular endothelial or smooth muscle cells.
Topics: Animals; Cells, Cultured; Deferoxamine; Endothelium, Vascular; Free Radical Scavengers; Iron Chelating Agents; Lipoproteins, LDL; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxidation-Reduction; Oxidative Stress; S-Nitroso-N-Acetylpenicillamine; S-Nitrosothiols; Superoxide Dismutase; Swine; Thiobarbituric Acid Reactive Substances | 2001 |
SIN-1-induced cytotoxicity in mixed cortical cell culture: peroxynitrite-dependent and -independent induction of excitotoxic cell death.
Topics: Animals; Astrocytes; Catalase; Cell Death; Cells, Cultured; Cerebral Cortex; Free Radical Scavengers; Mice; Molsidomine; Neurons; Neurotoxins; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2001 |
Comparative vasodilation of peroxynitrite and 3-morpholinosydnonimine.
Topics: Adenine; Animals; Benzoates; Cattle; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Female; Guanylate Cyclase; Imidazoles; In Vitro Techniques; Mammary Arteries; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Oxadiazoles; Oxazines; Oxidants; Peroxynitrous Acid; Vasodilation; Vasodilator Agents | 2001 |
Role of potassium channels in the relaxation induced by the nitric oxide (NO) donor DEA/NO in the isolated rat basilar artery.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Basilar Artery; Glyburide; Hydrazines; In Vitro Techniques; Male; Molsidomine; Nitric Oxide Donors; Nitrogen Oxides; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Vasodilation | 2001 |
Involvement of PKC and NF-kappaB in nitric oxide induced apoptosis in human coronary artery smooth muscle cells.
Topics: Apoptosis; Cell Nucleus; Cells, Cultured; Coronary Vessels; DNA Fragmentation; DNA-Binding Proteins; Enzyme Inhibitors; Humans; I-kappa B Proteins; Molsidomine; Muscle, Smooth, Vascular; Naphthalenes; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Protein Kinase C; Staurosporine; Tumor Suppressor Protein p53 | 2001 |
Regulation of taurine transporter expression by NO in cultured human retinal pigment epithelial cells.
Topics: Animals; Antioxidants; Ascorbic Acid; Carrier Proteins; Cell Line; Diabetes Mellitus; Dose-Response Relationship, Drug; Glutathione; Humans; Immunohistochemistry; Membrane Glycoproteins; Membrane Transport Proteins; Methylene Blue; Mice; Mice, Inbred ICR; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Pigment Epithelium of Eye; Protein Synthesis Inhibitors; Taurine; Time Factors; Tyrosine | 2001 |
Nitric oxide modulates cerebral blood flow stimulation by acetazolamide in the rat cortex: a laser Doppler scanning study.
Topics: Acetazolamide; Animals; Blood Pressure; Carbonic Anhydrase Inhibitors; Cerebral Cortex; Cerebrovascular Circulation; Laser-Doppler Flowmetry; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Wistar; Vasodilator Agents | 2001 |
Value of linsidomin in assessing myocardial viability with thallium-201 SPECT.
Topics: Aged; Cell Survival; Female; Heart; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Molsidomine; Myocardial Infarction; Myocardium; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon; Vasodilator Agents | 2001 |
Nuclear export of phosphorylated C/EBPbeta mediates the inhibition of albumin expression by TNF-alpha.
Topics: Active Transport, Cell Nucleus; Aged; Alanine; Animals; Antibiotics, Antineoplastic; Antioxidants; Cachexia; Case-Control Studies; CCAAT-Enhancer-Binding Protein-beta; Cell Nucleus; Cells, Cultured; CHO Cells; Cricetinae; Cytoplasm; Fatty Acids, Unsaturated; Hepatocytes; Humans; Immunoblotting; Immunohistochemistry; Lipopolysaccharides; Liver; Male; Mice; Middle Aged; Molsidomine; Mutation; Nitric Oxide Donors; Nitric Oxide Synthase; Oxidative Stress; Phosphorylation; Precipitin Tests; Promoter Regions, Genetic; Protein Structure, Tertiary; Serine; Serum Albumin; Time Factors; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha | 2001 |
Endothelial cell dysfunction in mice after transgenic knockout of type 2, but not type 1, 11beta-hydroxysteroid dehydrogenase.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Acetylcholine; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Fludrocortisone; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Isoenzymes; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Mineralocorticoids; Molsidomine; Norepinephrine; Potassium Chloride; RNA, Messenger; Serotonin; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Weight Gain | 2001 |
In vivo damage of CNS myelin and axons induced by peroxynitrite.
Topics: Animals; Axons; Central Nervous System; Male; Molsidomine; Myelin Sheath; Nitric Oxide Donors; Peroxynitrous Acid; Rats; Rats, Wistar | 2001 |
Microinfusion of a nitric oxide donor in discrete brain regions activates the hypothalamic-pituitary-adrenal axis.
Topics: Adrenocorticotropic Hormone; Amygdala; Animals; Coloring Agents; Evans Blue; Hippocampus; Hypothalamo-Hypophyseal System; Male; Microinjections; Molsidomine; Neostriatum; Nitric Oxide Donors; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley | 2001 |
17 beta-Estradiol inhibits carotid sinus baroreceptor activity in anesthetized male rats.
Topics: Anesthesia; Animals; Carotid Sinus; Estradiol; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Pressoreceptors; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Tamoxifen | 2001 |
Dehydroepiandrosterone inhibits the death of immunostimulated rat C6 glioma cells deprived of glucose.
Topics: Adjuvants, Immunologic; Animals; Astrocytes; Brain; Brain Ischemia; Cell Death; Cytokines; Dehydroepiandrosterone; Enzyme Inhibitors; Free Radical Scavengers; Glioma; Glucose; Herbicides; Humans; Interferon-gamma; Lipopolysaccharides; Metalloporphyrins; Molsidomine; Neurons; Nitric Oxide; Oxidative Stress; Paraquat; Peroxynitrous Acid; Superoxide Dismutase; Tumor Cells, Cultured; Tyrosine | 2001 |
Glucocorticoids exacerbate peroxynitrite mediated potentiation of glucose deprivation-induced death of rat primary astrocytes.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Astrocytes; Cell Death; Cells, Cultured; Dexamethasone; Glucocorticoids; Glucose; Hormone Antagonists; Interferon-gamma; Membrane Potentials; Mifepristone; Mitochondria; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley | 2001 |
Effects of nitric oxide on the Ca2+-activated potassium channels in smooth muscle cells of the human corpus cavernosum.
Topics: Cells, Cultured; Drug Synergism; Electric Conductivity; Electrophysiology; Humans; Male; Molsidomine; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Penis; Piperazines; Potassium Channels; Potassium Channels, Calcium-Activated; Purines; Sildenafil Citrate; Sulfones | 2001 |
Effect of selenolipoic acid on peroxynitrite-dependent inactivation of NADPH-cytochrome P450 reductase.
Topics: Animals; Enzyme Inhibitors; Free Radical Scavengers; In Vitro Techniques; Kinetics; Microsomes, Liver; Molsidomine; NADP; NADPH-Ferrihemoprotein Reductase; Nitric Oxide Donors; Peroxynitrous Acid; Rats; Sulfhydryl Compounds; Thioctic Acid | 2001 |
Direct antioxidant properties of creatine.
Topics: Animals; Anions; Antioxidants; Cations; Creatine; Dose-Response Relationship, Drug; Free Radical Scavengers; Free Radicals; Glutathione; Lipid Metabolism; Lipid Peroxidation; Molsidomine; Muscle, Skeletal; Rats; Rats, Inbred F344; Reactive Oxygen Species; Superoxides | 2002 |
Multiple substrates for paraoxonase-1 during oxidation of phosphatidylcholine by peroxynitrite.
Topics: Aryldialkylphosphatase; Enzyme Inhibitors; Esterases; Humans; Hydrolysis; Lipoproteins; Models, Chemical; Molsidomine; Oxygen; Peroxynitrous Acid; Phosphatidylcholines; Phosphatidylethanolamines; Protein Binding; Proteolipids; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Time Factors | 2002 |
Peroxynitrite increases iNOS through NF-kappaB and decreases prostacyclin synthase in endothelial cells.
Topics: Animals; Cattle; Cells, Cultured; Cyclooxygenase 2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Intramolecular Oxidoreductases; Isoenzymes; Molsidomine; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Prostaglandin-Endoperoxide Synthases | 2002 |
Cellular mechanisms of nitric oxide-induced relaxation of corporeal smooth muscle in the guinea-pig.
Topics: Animals; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Guinea Pigs; Intracellular Membranes; Male; Membrane Potentials; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nifedipine; Nitric Oxide; Nitric Oxide Donors; Norepinephrine; Osmolar Concentration; Penis; Potassium; Solutions | 2002 |
Selective nitration of mitochondrial complex I by peroxynitrite: involvement in mitochondria dysfunction and cell death of dopaminergic SH-SY5Y cells.
Topics: Adenosine Triphosphate; Apoptosis; Cell Death; Cysteine Proteinase Inhibitors; Dopamine; Electron Transport Complex I; Humans; Mitochondria; Molsidomine; NADH, NADPH Oxidoreductases; Nitric Oxide Donors; Oligopeptides; Peroxynitrous Acid; Subcellular Fractions; Tumor Cells, Cultured; Tyrosine | 2002 |
Nitric oxide synthase inhibition decreases output of hepatic insulin sensitizing substance (HISS), which is reversed by SIN-1 but not by nitroprusside.
Topics: Animals; Enzyme Inhibitors; Injections, Intravenous; Insulin; Insulin Resistance; Liver; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Portal Vein; Proteins; Rats | 2001 |
Actions of S-nitroso N-acetyl penicillamine and 3-morpholinosydonimine may involve disparate signaling pathways in myometrial smooth muscle.
Topics: Animals; Blotting, Western; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Female; Guanylate Cyclase; Guinea Pigs; Humans; In Vitro Techniques; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myometrium; Nitric Oxide Donors; Phosphorylation; S-Nitroso-N-Acetylpenicillamine; Signal Transduction | 2001 |
The effects of SIN-1 on contractility and cyclic GMP levels in the pregnant mouse uterus.
Topics: Acetylcholine; Animals; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; In Vitro Techniques; Isometric Contraction; Methylene Blue; Mice; Molsidomine; Nitric Oxide Donors; Pregnancy; Uterine Contraction; Uterus | 2001 |
Formation of peroxynitrite from reaction of nitroxyl anion with molecular oxygen.
Topics: Animals; Anions; Antioxidants; Cattle; Dose-Response Relationship, Drug; Hydrogen Peroxide; Hydrogen-Ion Concentration; Models, Chemical; Molsidomine; NAD; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitrogen Oxides; Oxygen; Peroxynitrous Acid; Rhodamines; Superoxide Dismutase | 2002 |
Oxidation and nitrosation in the nitrogen monoxide/superoxide system.
Topics: Animals; Biochemical Phenomena; Biochemistry; Cattle; Chelating Agents; Chromatography, High Pressure Liquid; Chromogenic Compounds; Disulfides; Dose-Response Relationship, Drug; Free Radicals; Hydrazines; Hydrogen Peroxide; Models, Chemical; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrogen; Nitrogen Oxides; Oxygen; Peroxynitrous Acid; Protein Binding; Resorcinols; Spectrophotometry; Spectrum Analysis, Raman; Spermine; Sulfhydryl Compounds; Superoxides; Time Factors; Ultraviolet Rays; Xanthine Oxidase; Zinc | 2002 |
Neuronal formation of free radicals plays a minor role in hypoxic cell death in human NT2-N neurons.
Topics: Antioxidants; Cell Death; Cell Hypoxia; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Free Radicals; Glucose; Humans; L-Lactate Dehydrogenase; Molsidomine; Neurons; Neuroprotective Agents; Oxygen; Reactive Oxygen Species; Tumor Cells, Cultured | 2002 |
Protective effects of dihydropyridine Ca-blockers against endothelial cell oxidative injury due to combined nitric oxide and superoxide.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cattle; Cell Survival; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Endothelium, Vascular; Glutathione; Lipid Peroxidation; Molsidomine; Nicardipine; Nifedipine; Nisoldipine; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Superoxides; Thiobarbituric Acid Reactive Substances | 2002 |
Formation of 8-nitroguanosine in cellular RNA as a biomarker of exposure to reactive nitrogen species.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Biomarkers; Carcinoma; Cattle; Deoxyguanosine; Guanine; Humans; Lung Neoplasms; Molsidomine; Peroxynitrous Acid; RNA, Neoplasm; Tumor Cells, Cultured | 2002 |
Insulin-like growth factor-1 protects peroxynitrite-induced cell death by preventing cytochrome c-induced caspase-3 activation.
Topics: Apoptosis; Caspase 3; Caspases; Cytochrome c Group; Dopamine; Drug Interactions; Enzyme Activation; Humans; Insulin-Like Growth Factor I; Molsidomine; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured | 2002 |
Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species.
Topics: Alginates; Apoptosis; Cell Survival; Cells, Cultured; Chondrocytes; Humans; Microspheres; Molsidomine; NAD; NADP; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitroprusside; Nitroso Compounds; Oxidative Stress; Reactive Oxygen Species; Triazenes | 2002 |
Human renal epithelial cells express iNOS in response to cytokines but not bacteria.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Child; Cytokines; Epithelial Cells; Escherichia coli Infections; Gene Expression Regulation, Enzymologic; Humans; Hydrogen Peroxide; Interferon-gamma; Interleukin-1; Kidney Tubules; Lipopolysaccharides; Macrophages; Mice; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxidants; Oxidative Stress; RNA, Messenger; Tumor Necrosis Factor-alpha; Urinary Tract Infections | 2002 |
Cross-talk between nitric oxide and superoxide determines ceramide formation and apoptosis in glomerular cells.
Topics: Animals; Apoptosis; Cattle; Cells, Cultured; Ceramides; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Synergism; Kidney Glomerulus; Molsidomine; Naphthoquinones; Nitric Oxide; Nitric Oxide Donors; Spermine; Superoxides | 2002 |
Intra-luminal exposure of murine airways to peroxynitrite causes inflammation but not hyperresponsiveness.
Topics: Acetylcholine; Animals; Bronchi; Bronchial Hyperreactivity; Inflammation; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Molsidomine; Peroxynitrous Acid; Trachea; Tyrosine | 2002 |
Evidence that peroxynitrite affects human osteoblast proliferation and differentiation.
Topics: Alkaline Phosphatase; Catalase; Cell Differentiation; Cell Division; Cells, Cultured; Humans; Interferon-gamma; Interleukin-1; Molsidomine; Nitric Oxide Donors; Nitrites; Osteoblasts; Peroxynitrous Acid; Recombinant Proteins; Superoxide Dismutase; Thymidine; Tumor Necrosis Factor-alpha; Tyrosine | 2002 |
Beneficial effects of nitric oxide inhalation on pulmonary bacterial clearance.
Topics: Administration, Inhalation; Animals; Blood Bactericidal Activity; Bronchoalveolar Lavage Fluid; Colony Count, Microbial; In Vitro Techniques; Male; Molsidomine; Neutrophil Infiltration; Neutrophils; Nitric Oxide; Nitric Oxide Donors; Oxidants; Pancreatic Elastase; Pneumonia, Bacterial; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome | 2002 |
3-Morpholinosydnonimine hydrochloride induces p53-dependent apoptosis in murine primary neural cells: a critical role for p21(ras)-MAPK-p19(ARF) pathway.
Topics: Animals; Apoptosis; Cyclin-Dependent Kinase Inhibitor p16; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; Molsidomine; Neurons; Nitric Oxide Donors; Peroxynitrous Acid; Proto-Oncogene Proteins p21(ras); Signal Transduction; Tumor Suppressor Protein p14ARF; Tumor Suppressor Protein p53 | 2002 |
The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antioxidants; Brain; Female; gamma-Tocopherol; Humans; Ketoglutarate Dehydrogenase Complex; Lipid Metabolism; Male; Mitochondria; Molsidomine; Nitric Oxide Donors; Reactive Nitrogen Species | 2002 |
Intracavernous administration of SIN-1+VIP in an in vivo rabbit model for erectile function.
Topics: Animals; Drug Combinations; Injections; Male; Molsidomine; Nitric Oxide Donors; Penile Erection; Penis; Pressure; Rabbits; Vasoactive Intestinal Peptide; Vasodilator Agents | 2002 |
Genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells exposed to peroxynitrite generated from SIN-1.
Topics: Apoptosis; Cell Survival; Cells, Cultured; Comet Assay; DNA; DNA Damage; Drug Antagonism; Free Radical Scavengers; Humans; Hypoxanthine Phosphoribosyltransferase; Lymphocytes; Mitochondria; Molsidomine; Mutagens; Peroxynitrous Acid; Thymidine Kinase; Vasodilator Agents | 2002 |
Exogenous nitric oxide inhibits VCAM-1 expression in human peritoneal mesothelial cells. Role of cyclic GMP and NF-kappaB.
Topics: Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Humans; Interleukin-1; Lipopolysaccharides; Molsidomine; NF-kappa B; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Peritoneum; Signal Transduction; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2002 |
[Effects of nitric oxide donor SIN-1 on calcium transport in rat cardiac sarcoplasmic reticulum].
Topics: Animals; Calcium; Calcium Channels; Ion Transport; Molsidomine; Myocardium; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Rats; Sarcoplasmic Reticulum; Superoxides | 2001 |
Vanadate protects human neuroblastoma SH-SY5Y cells against peroxynitrite-induced cell death.
Topics: Cell Death; Crk-Associated Substrate Protein; Cyclosporine; Enzyme Inhibitors; Humans; Molsidomine; Neuroblastoma; Nitric Oxide Donors; Okadaic Acid; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Protein Tyrosine Phosphatases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Retinoblastoma-Like Protein p130; Signal Transduction; Tumor Cells, Cultured; Vanadates | 2002 |
Protection of myocytes from hypoxia-reoxygenation injury by nitric oxide is mediated by modulation of transforming growth factor-beta1.
Topics: Animals; Cells, Cultured; Culture Media, Conditioned; Cytoprotection; Molsidomine; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Protein Kinase C; Rats; RNA, Messenger; Transcriptional Activation; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2002 |
Induction of SOS response in Salmonella typhimurium TA4107/pSK1002 by peroxynitrite-generating agent, N-morpholino sydnonimine.
Topics: Kinetics; Molsidomine; Oxidative Stress; Peroxynitrous Acid; Plasmids; Salmonella typhimurium; SOS Response, Genetics | 2002 |
Prevention of free-radical induced apoptosis by induction of human recombinant Cu, Zn-SOD in pig endothelial cells.
Topics: Animals; Apoptosis; Endothelium, Vascular; Free Radicals; Humans; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Reactive Oxygen Species; Superoxide Dismutase; Swine; Transplantation, Heterologous | 2002 |
Nitric oxide-cGMP-mediated vasoconstriction and effects of acetylcholine in the branchial circulation of the eel.
Topics: Acetylcholine; Animals; Arginine; Branchial Region; Cyclic GMP; Dose-Response Relationship, Drug; Eels; Endothelium, Vascular; Female; Gills; Hemoglobins; In Vitro Techniques; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Vasoconstriction | 2002 |
Expression of nitric oxide synthases and in vitro migration of eosinophils from allergic rhinitis subjects.
Topics: Cell Movement; Chemokine CCL11; Chemokines, CC; Chemotaxis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eosinophils; Guanylate Cyclase; Humans; Isoenzymes; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxadiazoles; Quinoxalines; Rhinitis, Allergic, Perennial; S-Nitroso-N-Acetylpenicillamine; Solubility | 2002 |
Centrally applied nitric oxide donor elevates plasma corticosterone by activation of the hypothalamic noradrenergic neurons in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Chloralose; Corticosterone; Cyclooxygenase Inhibitors; Indomethacin; Injections, Intraventricular; Male; Microdialysis; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Norepinephrine; Paraventricular Hypothalamic Nucleus; Phentolamine; Rats; Rats, Wistar; Sotalol; Time Factors; Urethane | 2002 |
Identification and in vitro biological activities of hop proanthocyanidins: inhibition of nNOS activity and scavenging of reactive nitrogen species.
Topics: Anthocyanins; Antioxidants; Biflavonoids; Catechin; Dimerization; Enzyme Inhibitors; Free Radical Scavengers; Humulus; Lipid Peroxidation; Lipoproteins, LDL; Molecular Structure; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Proanthocyanidins; Spectrometry, Mass, Electrospray Ionization; Thiobarbituric Acid Reactive Substances | 2002 |
Effect of SIN-1 in rat ventricular myocytes: interference with beta-adrenergic stimulation.
Topics: Animals; Caffeine; Calcium; Calcium Channels; Cyclic AMP; Cyclic GMP; Drug Interactions; Heart Ventricles; In Vitro Techniques; Molsidomine; Myocardium; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Vasodilator Agents | 2002 |
(-)-Deprenyl fails to promote axonal regeneration of retinal ganglion cells in vitro and in vivo.
Topics: Animals; Axons; Brain-Derived Neurotrophic Factor; Cell Survival; Free Radicals; Ganglia, Spinal; GAP-43 Protein; Gene Expression Regulation; Genes, bcl-2; Immunohistochemistry; In Vitro Techniques; Male; Molsidomine; Monoamine Oxidase Inhibitors; Nerve Degeneration; Nerve Regeneration; Neurites; Neuroprotective Agents; Optic Nerve; Oxidative Stress; Rats; Rats, Wistar; Receptor, trkA; Receptor, trkB; Retinal Ganglion Cells; Selegiline | 2002 |
Nitric oxide and peroxynitrite activate the iron regulatory protein-1 of J774A.1 macrophages by direct disassembly of the Fe-S cluster of cytoplasmic aconitase.
Topics: Aconitate Hydratase; Animals; Cell Line; Cell-Free System; Cytoplasm; Escherichia coli; Ferrous Compounds; Ferrozine; Iron Regulatory Protein 1; Iron Regulatory Protein 2; Iron-Regulatory Proteins; Iron-Sulfur Proteins; Macrophages; Mice; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Protein Processing, Post-Translational; Recombinant Proteins; RNA-Binding Proteins; Superoxides | 2002 |
Specificity of antioxidant enzyme inhibition in skeletal muscle to reactive nitrogen species donors.
Topics: Animals; Antioxidants; Catalase; Diethylamines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione Peroxidase; Molsidomine; Muscle, Skeletal; Nitric Oxide Donors; Nitrogen Oxides; Nitroprusside; Rats; Rats, Inbred F344; Reactive Nitrogen Species; S-Nitroso-N-Acetylpenicillamine; Superoxide Dismutase | 2002 |
The effects of the nitric oxide donor SIN-1 on ischemia-reperfused cutaneous and myocutaneous flaps.
Topics: Animals; Cell Survival; Female; Molsidomine; Neutrophils; Nitric Oxide Donors; Reperfusion Injury; Surgical Flaps; Swine | 2002 |
Adenosine and purine nucleosides protect rat primary astrocytes from peroxynitrite-potentiated, glucose deprivation-induced death: preservation of intracellular ATP level.
Topics: Adenosine; Adenosine Triphosphate; Animals; Astrocytes; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Glioma; Glucose; Intracellular Fluid; L-Lactate Dehydrogenase; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Purine Nucleosides; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley | 2002 |
Peroxynitrite enhances the ability of Salmonella dublin to invade T84 monolayers.
Topics: Cell Division; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; Humans; Intestines; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrogen; Nitrogen Oxides; omega-N-Methylarginine; Peroxynitrous Acid; Salmonella; Salmonella typhimurium; Spermine | 2002 |
Effect of linsidomine on the human radial artery.
Topics: Angiotensin II; Arginine Vasopressin; Carbachol; Cholinergic Agonists; Culture Techniques; Dose-Response Relationship, Drug; Humans; Molsidomine; Nitroglycerin; Radial Artery; Vasoconstriction; Vasodilation; Vasodilator Agents | 2002 |
Effects of a nitric oxide donor on behavior and interaction with nitrous oxide in the mouse light/dark exploration test.
Topics: Animals; Darkness; Exploratory Behavior; Injections, Intraventricular; Light; Male; Mice; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrous Oxide | 2002 |
Effects of sulfur containing amino acids on iron and nitric oxide stimulated catecholamine oxidation.
Topics: Amino Acids, Sulfur; Catecholamines; Chlorides; Ferric Compounds; Levodopa; Molsidomine; Nitric Oxide; Nitroprusside; Norepinephrine; Oxidation-Reduction; Taurine | 2002 |
ATP and nitric oxide modulate a Ca(2+)-activated non-selective cation current in macrovascular endothelial cells.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Calcium; Cations; Cell Line; Electrophysiology; Endothelium, Vascular; Humans; Ion Channels; Membrane Potentials; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Umbilical Veins | 2002 |
Comparison between the influence of the intravenous and intracerebroventricular injection of a nitric oxide donor on adrenocorticotropic hormone release and hypothalamic neuronal activity.
Topics: Adrenocorticotropic Hormone; Animals; Hypothalamus; Injections, Intravenous; Injections, Intraventricular; Male; Molsidomine; Neurons; Nitric Oxide Donors; Pituitary Gland; Rats; Rats, Sprague-Dawley | 2002 |
The effect of the nitric oxide synthesis inhibitor L-NAME on amitriptyline-induced hypotension in rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Drug Interactions; Enzyme Inhibitors; Hypotension; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Rats; Rats, Wistar | 2002 |
Reduction of macrophage activation after antioxidant enzymes gene transfer to rat insulinoma INS-1 cells.
Topics: Animals; Antioxidants; Catalase; Cells, Cultured; Culture Media, Conditioned; Cytokines; Gene Expression Regulation, Enzymologic; Gene Transfer Techniques; Hydrogen Peroxide; Insulinoma; Macrophage Activation; Macrophages, Peritoneal; Molsidomine; Oxidants; Oxidative Stress; Pancreatic Neoplasms; Rats; Superoxide Dismutase | 2002 |
Effects of nitric oxide donors on vascular endothelial growth factor gene induction.
Topics: Blotting, Northern; Blotting, Western; Cell Nucleus; Dithiothreitol; Dose-Response Relationship, Drug; Endothelial Growth Factors; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Luciferases; Lymphokines; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitroprusside; Oxidation-Reduction; Penicillamine; Plasmids; Promoter Regions, Genetic; Pyridines; Reducing Agents; RNA; RNA, Messenger; S-Nitrosoglutathione; Transcription Factors; Triazenes; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
NO- and non-NO-, non-prostanoid-dependent vasodilatation in rat sciatic nerve during maturation and developing experimental diabetic neuropathy.
Topics: Acetylcholine; Animals; Blood Glucose; Blood Pressure; Cyclooxygenase Inhibitors; Diabetic Neuropathies; Fasting; Glycated Hemoglobin; Indomethacin; Male; Molsidomine; Motor Neurons; Neural Conduction; Neurons, Afferent; Nitric Oxide; Nitric Oxide Synthase; Potassium Channel Blockers; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Vasodilation; Vasodilator Agents | 2002 |
Nitric oxide synthase inhibition and glutamate binding in quinolinate-lesioned rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cell Membrane; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Kainic Acid; Male; Molsidomine; N-Methylaspartate; Nerve Degeneration; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Quinolinic Acid; Quisqualic Acid; Rats; Rats, Wistar; Tritium | 2002 |
Peroxynitrite triggers a delayed resistance of coronary endothelial cells against ischemia-reperfusion injury.
Topics: Acetylcholine; Animals; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; Free Radicals; Ischemic Preconditioning, Myocardial; Male; Methionine; Molsidomine; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Peroxynitrous Acid; Rats; Rats, Wistar; Selenomethionine; Uric Acid | 2002 |
Ciclopirox prevents peroxynitrite toxicity in astrocytes by maintaining their mitochondrial function: a novel mechanism for cytoprotection by ciclopirox.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Cell Cycle; Cell Death; Cells, Cultured; Ciclopirox; Flow Cytometry; Glutathione; Hydrogen Peroxide; Hydroxyl Radical; L-Lactate Dehydrogenase; Membrane Potentials; Mitochondria; Molsidomine; Neuroprotective Agents; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Pyridones; Rats; Rats, Sprague-Dawley; Rhodamines; Serum Albumin, Bovine; Superoxides; Tyrosine | 2002 |
NMDA-induced acetylcholine release in mouse striatum: role of NO synthase isoforms.
Topics: Acetylcholine; Animals; Corpus Striatum; Drug Administration Routes; Isoenzymes; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Molsidomine; N-Methylaspartate; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Perfusion | 2002 |
Peroxynitrite scavenging activity of sinapic acid (3,5-dimethoxy-4-hydroxycinnamic acid) isolated from Brassica juncea.
Topics: Brassica; Coumaric Acids; Free Radical Scavengers; Lipid Peroxidation; Lipoproteins, LDL; Molsidomine; Nitrates; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Serum Albumin, Bovine; Superoxides; Tyrosine | 2002 |
Peroxynitrite enhances astrocytic volume-sensitive excitatory amino acid release via a src tyrosine kinase-dependent mechanism.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Cell Size; Cells, Cultured; Enzyme Inhibitors; Excitatory Amino Acids; Intracellular Fluid; Ion Channels; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; src-Family Kinases; Superoxide Dismutase | 2002 |
Enhanced activity of human IL-10 after nitration in reducing human IL-1 production by stimulated peripheral blood mononuclear cells.
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Deferoxamine; Dithiothreitol; Down-Regulation; Humans; Hydrogen Peroxide; Interleukin-1; Interleukin-10; Leukocytes, Mononuclear; Molsidomine; Peroxynitrous Acid; Reducing Agents | 2002 |
The essential nutrient pyrroloquinoline quinone may act as a neuroprotectant by suppressing peroxynitrite formation.
Topics: Animals; Brain; Cell Survival; Dose-Response Relationship, Drug; Fetus; Molsidomine; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; PQQ Cofactor; Quinolones; Quinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stroke; Superoxides | 2002 |
Exogenous nitric oxide inhibits tumor necrosis factor-alpha- or interleukin-1-beta-induced monocyte chemoattractant protein-1 expression in human mesangial cells. Role of IkappaB-alpha and cyclic GMP.
Topics: Cells, Cultured; Chemokine CCL2; Cyclic GMP; Glomerular Mesangium; Guanylate Cyclase; Humans; I-kappa B Proteins; Interleukin-1; Molsidomine; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Protein Binding; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha | 2002 |
Effects of the nitric oxide donor 3-morpholinosydnonimine (SIN-1) in focal cerebral ischemia dependent on intracellular brain pH.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Cerebrovascular Circulation; Hydrogen-Ion Concentration; Male; Molsidomine; NAD; Nitric Oxide Donors; Oxidation-Reduction; Rats; Rats, Wistar | 2002 |
Nitric oxide inhibits capacitative Ca2+ entry by suppression of mitochondrial Ca2+ handling.
Topics: Barium; Calcium; Cell Line; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Humans; Intracellular Membranes; Membrane Potentials; Mitochondria; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Oxygen Consumption; Peroxynitrous Acid; Quinoxalines; Thapsigargin; Time Factors | 2002 |
Irreversible inactivation of magnesium-dependent neutral sphingomyelinase 1 (NSM1) by peroxynitrite, a nitric oxide-derived oxidant.
Topics: Animals; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydrogen Peroxide; Magnesium; Mice; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Oxidants; Oxidative Stress; Peroxynitrous Acid; Reducing Agents; Sphingomyelin Phosphodiesterase | 2002 |
Comparison of uric acid and ascorbic acid in protection against EAE.
Topics: Albumins; Animals; Antioxidants; Ascorbic Acid; Blood-Brain Barrier; Cell Line; Encephalomyelitis, Autoimmune, Experimental; Free Radicals; Immunohistochemistry; Iron; Lipid Peroxidation; Mice; Molsidomine; Myelin Sheath; Nitric Oxide; Oxygen; Peroxynitrous Acid; Rhodamines; Time Factors; Tyrosine; Uric Acid | 2002 |
Nitric oxide inhibits irreversibly P815 cell proliferation: involvement of potassium channels.
Topics: Animals; Antineoplastic Agents; Cell Count; Cell Division; Coloring Agents; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gentian Violet; Growth Inhibitors; Guanylate Cyclase; Kinetics; Mastocytoma; Mice; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Potassium Channel Blockers; Potassium Channels; Tumor Cells, Cultured | 2002 |
Peroxynitrite generated in the rat spinal cord induces neuron death and neurological deficits.
Topics: Animals; Cell Death; Dyskinesia, Drug-Induced; Male; Microdialysis; Molsidomine; Nerve Degeneration; Neurons; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries | 2002 |
Peroxynitrite activates NF-E2-related factor 2/antioxidant response element through the pathway of phosphatidylinositol 3-kinase: the role of nitric oxide synthase in rat glutathione S-transferase A2 induction.
Topics: Amino Acids, Sulfur; Animals; Antioxidants; Cell Nucleus; Cytosol; DNA-Binding Proteins; Enzyme Induction; Glutathione Transferase; Liver Neoplasms, Experimental; Molsidomine; NF-E2-Related Factor 2; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Rats; Response Elements; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Trans-Activators; Tumor Cells, Cultured | 2002 |
Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors.
Topics: Administration, Oral; Animals; Biotransformation; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Encephalomyelitis, Autoimmune, Experimental; Enzyme Induction; Enzyme Inhibitors; Female; Humans; Inosine; Inosine Monophosphate; Mice; Molsidomine; Monocytes; Multiple Sclerosis; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxidative Stress; Oxonic Acid; Peroxynitrous Acid; Urate Oxidase; Uric Acid; Xanthines | 2002 |
Influence of nitric oxide on the spontaneous activity of globus pallidus neurones in the rat.
Topics: Action Potentials; Animals; Enzyme Inhibitors; Globus Pallidus; Male; Molsidomine; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar | 2002 |
Nitric oxide and peroxynitrite promote complete disruption of the [4Fe-4S] cluster of recombinant human iron regulatory protein 1.
Topics: Aconitate Hydratase; Blotting, Western; Conserved Sequence; Electrophoretic Mobility Shift Assay; Ferrozine; Humans; Iron Regulatory Protein 1; Iron-Sulfur Proteins; Mercaptoethanol; Molsidomine; Nitrates; Nitric Oxide; Peroxynitrous Acid; Recombinant Proteins; Superoxide Dismutase; Tyrosine | 2003 |
Hepatic glutathione and nitric oxide are critical for hepatic insulin-sensitizing substance action.
Topics: Animals; Buthionine Sulfoximine; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glutathione; Injections, Intravenous; Insulin; Insulin Resistance; Liver; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Parasympathetic Nervous System; Portal System; Rats; Rats, Wistar | 2003 |
Expression of prion protein increases cellular copper binding and antioxidant enzyme activities but not copper delivery.
Topics: Animals; Antioxidants; Blotting, Western; Cell Membrane; Cell Survival; Copper; Dose-Response Relationship, Drug; Doxycycline; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Manganese; Mice; Microscopy, Fluorescence; Molsidomine; Oxidative Stress; Prions; Protein Binding; Signal Transduction; Superoxide Dismutase; Time Factors | 2003 |
Peroxynitrite generated in the rat spinal cord induces oxidation and nitration of proteins: reduction by Mn (III) tetrakis (4-benzoic acid) porphyrin.
Topics: 2,4-Dinitrophenol; Animals; Drug Interactions; Enzyme Inhibitors; Free Radical Scavengers; Immunohistochemistry; Male; Metalloporphyrins; Microdialysis; Molsidomine; Neurons; Oxidation-Reduction; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Time Factors; Tyrosine | 2003 |
Fructose-1,6-bisphosphate preserves intracellular glutathione and protects cortical neurons against oxidative stress.
Topics: Animals; Buthionine Sulfoximine; Carmustine; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Free Radicals; Fructosediphosphates; Glutathione; Glutathione Reductase; Intracellular Fluid; Mice; Molsidomine; Neurons; Neuroprotective Agents; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Tetrazolium Salts; Thiazoles | 2003 |
Indirect measurement of nitric oxide production by monitoring nitrate and nitrite using microchip electrophoresis with electrochemical detection.
Topics: Electrochemistry; Electrophoresis; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Oxidation-Reduction; Reproducibility of Results; Sensitivity and Specificity | 2002 |
The role of reactive oxygen species in action of nitric oxide-donors on stress-induced gastric mucosal lesions.
Topics: Aldehydes; Animals; Aspirin; Gastric Mucosa; Lipid Peroxidation; Male; Malondialdehyde; Molsidomine; Nitric Oxide Donors; Nitroglycerin; Rats; Rats, Wistar; Reactive Oxygen Species; Regional Blood Flow; S-Nitroso-N-Acetylpenicillamine; Statistics, Nonparametric; Stomach Ulcer; Stress, Psychological; Superoxide Dismutase | 2002 |
Endothelial secretogogues and deformability of erythrocytes.
Topics: Animals; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Erythrocyte Deformability; Iloprost; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar | 2002 |
Peroxynitrite generated in the rat spinal cord induces apoptotic cell death and activates caspase-3.
Topics: Animals; Apoptosis; Caspase 3; Caspases; DNA Fragmentation; Immunohistochemistry; In Situ Nick-End Labeling; Male; Microdialysis; Microscopy, Electron; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries | 2003 |
Control of cardiovascular function in the icefish Chionodraco hamatus: involvement of serotonin and nitric oxide.
Topics: Acetylcholine; Animals; Antarctic Regions; Cardiovascular Physiological Phenomena; Cardiovascular System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Fishes; Gills; Hemodynamics; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; omega-N-Methylarginine; Ornithine; Serotonin; Vasoconstriction | 2003 |
Possible involvement of nitric oxide in the central salt-loading-induced cardiovascular responses in conscious rats.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Extracellular Space; Heart Rate; Hemodynamics; Male; Microdialysis; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; omega-N-Methylarginine; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Saline Solution, Hypertonic | 2003 |
Gender-related differences in the effects of nitric oxide donors on neuroleptic-induced catalepsy in mice.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Catalepsy; Female; Haloperidol; Isosorbide Dinitrate; Male; Mice; Molsidomine; Nitric Oxide Donors; S-Nitroso-N-Acetylpenicillamine; Sex Factors | 2003 |
Human sensitive to apoptosis gene protein inhibits peroxynitrite-induced DNA damage.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Antioxidants; Cysteine; Deoxyguanosine; DNA Damage; Dose-Response Relationship, Drug; Ethylmaleimide; Humans; Molsidomine; Peroxynitrous Acid; RNA-Binding Proteins; Sulfhydryl Reagents; Ubiquitin-Protein Ligases | 2003 |
Effects of various nitric oxide-donating drugs on adrenergic tension of human seminal vesicles in vitro.
Topics: Adrenergic alpha-Agonists; Aged; Colforsin; Cyclic GMP; Ejaculation; Erectile Dysfunction; Humans; In Vitro Techniques; Isometric Contraction; Male; Middle Aged; Molsidomine; Muscle Contraction; Muscle, Smooth; Nitric Oxide Donors; Nitroprusside; Norepinephrine; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Seminal Vesicles; Sexual Dysfunction, Physiological; Signal Transduction | 2003 |
Mitogen-activated protein kinases mediate peroxynitrite-induced cell death in human bronchial epithelial cells.
Topics: Bronchi; Cell Death; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; MAP Kinase Signaling System; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Respiratory Mucosa; Superoxides | 2003 |
Reactive nitrogen species block cell cycle re-entry through sustained production of hydrogen peroxide.
Topics: Animals; Catalase; Cell Cycle; Cells, Cultured; Cyclin D1; Epithelial Cells; Fluoresceins; Gene Expression Regulation; Hydrogen Peroxide; Mice; Molsidomine; Nitric Oxide Donors; Nitrogen Dioxide; Oxidants; Pulmonary Alveoli; Signal Transduction; Superoxide Dismutase; Transcription Factor AP-1; Tyrosine | 2003 |
Nitric oxide modulates striatal neuronal activity via soluble guanylyl cyclase: an in vivo microiontophoretic study in rats.
Topics: Action Potentials; Animals; Corpus Striatum; Guanylate Cyclase; Iontophoresis; Male; Molsidomine; Neurons; Nitric Oxide; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Solubility; Soluble Guanylyl Cyclase | 2003 |
Effect of SNI-2011 on amylase secretion from parotid tissue in rats and in neuronal nitric oxide synthase knockout mice.
Topics: Alkaloids; Amylases; Animals; Azepines; Benzoates; Benzylamines; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Carbazoles; Chelating Agents; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Gallic Acid; Genotype; Guanylate Cyclase; Imidazoles; In Vitro Techniques; Indoles; Male; Mice; Mice, Knockout; Molsidomine; Muscarinic Agonists; Myosin-Light-Chain Kinase; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Parotid Gland; Penicillamine; Phosphodiesterase Inhibitors; Pilocarpine; Protein Kinase Inhibitors; Pyrroles; Pyrrolidinones; Quinoxalines; Quinuclidines; Rats; Rats, Wistar; Sulfonamides; Thiophenes; Type C Phospholipases | 2003 |
Inhibition of actin polymerization by peroxynitrite modulates neutrophil functional responses.
Topics: Actins; Chemotaxis; Dimerization; Dose-Response Relationship, Drug; Humans; Molsidomine; Neutrophil Activation; Neutrophils; Nitric Oxide Donors; Peroxynitrous Acid; Phagocytosis; Reactive Oxygen Species; Respiratory Burst; Tyrosine | 2003 |
Activation of calcium-dependent calmodulin by calcium(II)3(3,5-diisopropylsalicylate)6(H2O)6 decreases thrombin receptor activating peptide-induced P-selectin expression.
Topics: Adenosine Diphosphate; Adult; Blood Platelets; Calcium; Calmodulin; Cross-Sectional Studies; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flow Cytometry; Humans; In Vitro Techniques; Male; Molsidomine; Nitric Oxide Synthase; omega-N-Methylarginine; P-Selectin; Peptide Fragments; Platelet Aggregation Inhibitors; Salicylates | 2003 |
Increased sensitivity to endothelial nitric oxide (NO) contributes to arterial normotension in mice with vascular smooth muscle-selective deletion of the atrial natriuretic peptide (ANP) receptor.
Topics: Acetylcholine; Administration, Oral; Animals; Aorta; Arteries; Blood Pressure; Blotting, Western; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Guanylate Cyclase; Mice; Mice, Knockout; Molsidomine; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Protein Structure, Tertiary; Receptors, Atrial Natriuretic Factor; Vasodilator Agents | 2003 |
The trypanothione-thiol system in Trypanosoma cruzi as a key antioxidant mechanism against peroxynitrite-mediated cytotoxicity.
Topics: Animals; Antioxidants; Biochemistry; Blotting, Western; Chromatography, High Pressure Liquid; Disulfides; Dose-Response Relationship, Drug; Glutathione; Macrophages; Models, Chemical; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrogen; Oxygen; Peroxynitrous Acid; Sulfhydryl Compounds; Time Factors; Trypanosoma cruzi; Tyrosine | 2003 |
Neuroprotective effects of alpha-tocopherol on oxidative stress in rat striatal cultures.
Topics: alpha-Tocopherol; Animals; Apoptosis; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Corpus Striatum; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fetus; Glutamate-Cysteine Ligase; Hydrogen Peroxide; Molsidomine; Neuroprotective Agents; Nitric Oxide Donors; Oxidative Stress; Paraquat; Protein Kinase C; Rats; S-Nitrosothiols; Staurosporine | 2003 |
Deactivation of norepinephrine by peroxynitrite as a new pathogenesis in the hypotension of septic shock.
Topics: Anesthesia; Animals; Aorta, Thoracic; Binding, Competitive; Blood Pressure; Hydrogen-Ion Concentration; Hypotension; In Vitro Techniques; Male; Molsidomine; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxidation-Reduction; Peroxynitrous Acid; Rats; Rats, Wistar; Shock, Septic; Vasoconstrictor Agents | 2003 |
Nitrergic modulation of hippocampal acetylcholine release is independent of endothelial NO synthase activity.
Topics: Acetylcholine; Animals; Enzyme Inhibitors; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Knockout; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroarginine | 2003 |
Involvement of nitric oxide donor compounds in the bactericidal activity of human neutrophils in vitro.
Topics: Escherichia coli; Humans; Molsidomine; Neutrophils; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitroprusside; Phagocytosis; Proteus vulgaris; Reactive Oxygen Species; Salmonella enterica | 2003 |
Three model systems measure oxidation/nitration damage caused by peroxynitrite.
Topics: Antioxidants; DNA Damage; DNA, Superhelical; Escherichia coli; Fruit; Luciferases; Luminescent Measurements; Luminol; Molsidomine; Mutation; Nitrates; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Phenols; Plasmids; Solutions; Tea | 2003 |
Role of specific adrenergic receptors in mediating the adrenocorticotropic hormone response to increased nitric oxide levels.
Topics: Adrenal Glands; Adrenergic Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adrenocorticotropic Hormone; Animals; Clonidine; Dobutamine; Hypothalamus; Injections, Intraventricular; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Norepinephrine; Phenylephrine; Pituitary Gland; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic | 2003 |
Inhibition of arginine synthesis by urea: a mechanism for arginine deficiency in renal failure which leads to increased hydroxyl radical generation.
Topics: Animals; Arginine; Cells, Cultured; Dose-Response Relationship, Drug; Guanidines; Hepatocytes; Hydroxyl Radical; Male; Models, Biological; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Ornithine; Oxygen; Rats; Rats, Wistar; Reactive Oxygen Species; Renal Insufficiency; Succinates; Urea | 2003 |
Nitric oxide disrupts VE-cadherin complex in murine microvascular endothelial cells.
Topics: Animals; Antigens, CD; Cadherins; Capillary Permeability; Cell Line; Endothelium, Vascular; Macromolecular Substances; Male; Mice; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Penicillamine; RNA, Messenger; Skin | 2003 |
Increased endothelin-1 and endothelin receptor expression in myocytes of ischemic and reperfused rat hearts and ventricular myocytes exposed to ischemic conditions and its inhibition by nitric oxide generation.
Topics: Acidosis; Animals; Animals, Newborn; Blotting, Southern; Cells, Cultured; Electrophoresis; Endothelin-1; Gene Expression; Male; Molsidomine; Mutation; Myocardial Reperfusion Injury; Myocytes, Cardiac; Nitric Oxide Donors; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA; Transcription, Genetic | 2003 |
Endothelium dysfunction in LDL receptor knockout mice: a role for H2O2.
Topics: Acetylcholine; Amitrole; Animals; Aorta, Thoracic; Arteriosclerosis; Catalase; Endothelium; Endothelium-Dependent Relaxing Factors; Hydrogen Peroxide; Indomethacin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitroarginine; Phenylephrine; Receptors, LDL; Superoxide Dismutase | 2003 |
Opposite nociceptive effects of the arginine/NO/cGMP pathway stimulation in dermal and subcutaneous tissues.
Topics: Animals; Arginine; Bucladesine; Cyclic GMP; Dermis; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Subcutaneous; Male; Molsidomine; Nitric Oxide; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Subcutaneous Tissue; Time Factors | 2003 |
Effect of alpha-tocopherol on the oxidative modification of apolipoprotein E in human very-low-density lipoprotein.
Topics: alpha-Tocopherol; Apolipoproteins E; Copper Sulfate; Heparin; Humans; Lipid Peroxidation; Lipoproteins, VLDL; Molsidomine; Oxidation-Reduction | 2003 |
Synthesis of beta-lactamase activated nitric oxide donors.
Topics: beta-Lactamases; Cephalosporins; Molsidomine; Nitric Oxide Donors; Nitrites; Nitrosamines; Prodrugs | 2003 |
Protection of insulin-secreting INS-1 cells against oxidative stress through adenoviral-mediated glutathione peroxidase overexpression.
Topics: Adenoviridae; Animals; Cattle; Cell Survival; DNA, Complementary; Enzyme Inhibitors; Glucose; Glutathione Peroxidase; Hypoxanthine; Insulin; Insulin Secretion; Insulinoma; Molsidomine; Oxidative Stress; Pancreatic Neoplasms; Rats; Recombinant Proteins; Superoxide Dismutase; Transfection; Tumor Cells, Cultured; Xanthine Oxidase | 2003 |
Peroxynitrite-induced oxidation of plasma lipids is enhanced in stable hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; F2-Isoprostanes; Female; Humans; Kidney Failure, Chronic; Lipids; Male; Membranes, Artificial; Middle Aged; Molsidomine; Nitric Oxide Donors; Oxidation-Reduction; Peroxynitrous Acid; Renal Dialysis; Tocopherols; Uric Acid | 2003 |
Nitric oxide-induced inhibition on striatal cells and excitation on globus pallidus neurons: a microiontophoretic study in the rat.
Topics: Action Potentials; Animals; Corpus Striatum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Globus Pallidus; Glutamic Acid; Iontophoresis; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Vasodilator Agents | 2003 |
Mitochondrial ATP-sensitive potassium channel: a novel site for neuroprotection.
Topics: Animals; Bradykinin; Cell Culture Techniques; Cell Survival; Cytoprotection; Decanoic Acids; Diazoxide; Glutamic Acid; Glyburide; Hydroxy Acids; Membrane Potentials; Membrane Proteins; Mitochondria; Molsidomine; Neurons; Neuroprotective Agents; Nitroprusside; Potassium Channels; Rats; Rats, Wistar; Retina | 2003 |
Dissociation of cGMP accumulation and relaxation in myometrial smooth muscle: effects of S-nitroso-N-acetylpenicillamine and 3-morpholinosyndonimine.
Topics: Animals; Calcium; Calcium Signaling; Cell Adhesion Molecules; Cyclic GMP; Dose-Response Relationship, Drug; Female; Fura-2; Guinea Pigs; Microfilament Proteins; Molsidomine; Muscle Contraction; Muscle, Smooth; Myometrium; Nitric Oxide; Nitric Oxide Donors; Oxytocin; Phosphoproteins; Phosphorylation; S-Nitroso-N-Acetylpenicillamine; Up-Regulation | 2003 |
Protective activity of (-)-epicatechin 3-O-gallate against peroxynitrite-mediated renal damage.
Topics: Animals; Antioxidants; Caspases; Catechin; Cell Cycle; Cell Line; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Drug; Flow Cytometry; Glutathione; Glutathione Peroxidase; Kidney; Lipid Peroxides; Lipopolysaccharides; LLC-PK1 Cells; Male; Molsidomine; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Rhodamines; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors; Tyrosine | 2003 |
Grape and grape seed extract capacities at protecting LDL against oxidation generated by Cu2+, AAPH or SIN-1 and at decreasing superoxide THP-1 cell production. A comparison to other extracts or compounds.
Topics: Amidines; Antioxidants; Catechin; Cell Line; Copper; Flavonoids; Humans; Lipoproteins, LDL; Molsidomine; Monocytes; Olea; Oxidants; Oxidation-Reduction; Oxidative Stress; Phenols; Plant Extracts; Polyphenols; Seeds; Spectrometry, Fluorescence; Superoxides; Time Factors; Vitis | 2003 |
Role of intracellular calcium mobilization and cell-density-dependent signaling in oxidative-stress-induced cytotoxicity in HaCaT keratinocytes.
Topics: Buffers; Calcium; Calcium Signaling; Caspases; Cell Count; Cells, Cultured; Chelating Agents; Cytotoxins; Egtazic Acid; Extracellular Space; Humans; Keratinocytes; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases | 2003 |
Local infusion of the nitric oxide donor Sin-1 after angioplasty. Effects on intimal hyperplasia in porcine coronary arteries.
Topics: Angioplasty, Balloon, Coronary; Animals; Coronary Restenosis; Coronary Vessels; Female; Hyperplasia; Male; Molsidomine; Nitric Oxide Donors; Nitric Oxide Synthase; Sodium-Potassium-Exchanging ATPase; Swine; Tunica Intima | 2003 |
Effects of nitric oxide on morphology of isolated cochlear outer hair cells: possible involvement in sensorineural hearing loss.
Topics: Animals; Cell Nucleus; Cell Size; Chinchilla; Hair Cells, Auditory, Outer; Hearing Loss, Sensorineural; Inflammation Mediators; Molsidomine; Nitric Oxide; Nitric Oxide Donors; S-Nitroso-N-Acetylpenicillamine | 2003 |
Metallothionein attenuates 3-morpholinosydnonimine (SIN-1)-induced oxidative stress in dopaminergic neurons.
Topics: alpha-Synuclein; Animals; Apoptosis; Caspase 3; Caspases; Cell Line, Tumor; Corpus Striatum; Deoxyadenosines; Dopamine; Gene Expression Regulation; Humans; Lipid Peroxidation; Metallothionein; Metals; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Molsidomine; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Oxidative Stress; Selegiline; Stem Cells; Synucleins; Transcriptional Activation | 2003 |
Reactive oxygen species inhibited by titanium oxide coatings.
Topics: Aluminum; Animals; Coated Materials, Biocompatible; Cytokines; Macrophages; Mice; Molsidomine; Peroxynitrous Acid; Phenylacetates; Reactive Oxygen Species; Silicones; Titanium | 2003 |
Toxicity of nitric oxide and peroxynitrite to Photobacterium damselae subsp. piscicida.
Topics: Analysis of Variance; Culture Media; Glucose; Molsidomine; Nitric Oxide; Peroxynitrous Acid; Photobacterium; S-Nitroso-N-Acetylpenicillamine | 2003 |
Peroxynitrite and NO+ donors form colored nitrite adducts with sinapinic acid: potential applications.
Topics: Coumaric Acids; Kinetics; Molsidomine; Nitric Oxide Donors; Nitrites; Nitrous Acid; Peroxynitrous Acid; Rhodamines; S-Nitrosoglutathione | 2003 |
Influence of the direct NO-donor SIN-1 on the interaction between platelets and stainless steel stents under dynamic conditions.
Topics: Adult; Biocompatible Materials; Biomarkers; Blood Coagulation; Female; Humans; Male; Models, Cardiovascular; Molsidomine; Nitric Oxide Donors; Perfusion; Platelet Adhesiveness; Platelet Aggregation; Stainless Steel; Stents | 2003 |
The role of nitric oxide in systemic and hepatic haemodynamics in the rat in vivo.
Topics: Animals; Arginine; Blood Pressure; Dose-Response Relationship, Drug; Drug Interactions; Heart Rate; Hepatic Artery; Liver Circulation; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Portal Vein; Rats; Rats, Wistar | 2003 |
Effects of exogenous nitric oxide on the function of isolated working hearts.
Topics: Animals; Coronary Circulation; Cyclic GMP; Heart; Molsidomine; Myocardial Contraction; Myocardium; Nitric Oxide; Nitric Oxide Donors | 1999 |
Role of nitric oxide in leukocyte-independent endothelial damage during experimental endotoxemia.
Topics: Animals; Cell Adhesion; Endothelium, Vascular; Endotoxemia; Erythrocytes; Leukocytes; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Polysaccharides; Rats; Rats, Wistar; Time Factors | 2003 |
Molecular basis and characteristics of KATP channel in human corporal smooth muscle cells.
Topics: ATP-Binding Cassette Transporters; Cells, Cultured; Electric Conductivity; Electrophysiology; Glyburide; Humans; Male; Membrane Potentials; Molsidomine; Muscle, Smooth, Vascular; Penis; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Vasodilator Agents | 2003 |
Inactivation of platelet glycoprotein IIb/IIIa receptor by nitric oxide donor 3-morpholino-sydnonimine.
Topics: Blood Platelets; Flow Cytometry; Humans; Molsidomine; Nitric Oxide Donors; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Statistics as Topic; Time Factors | 2003 |
Ionotropic glutamate-receptor antagonists inhibit the aversive effects of nitric oxide donor injected into the dorsolateral periaqueductal gray of rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Excitatory Amino Acid Antagonists; Male; Molsidomine; Motor Activity; Nitric Oxide; Nitric Oxide Donors; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Time Factors | 2004 |
Novel SIN-1 reactive intermediates modulate chloride secretion across murine airway cells.
Topics: Animals; Chloride Channels; Chlorides; Electric Conductivity; Ion Transport; Male; Mass Spectrometry; Mice; Molecular Structure; Molsidomine; Patch-Clamp Techniques; Reactive Oxygen Species; Spectrometry, Mass, Electrospray Ionization; Trachea | 2003 |
Human plasminogen is highly susceptible to peroxynitrite inactivation.
Topics: Antithrombin III; Chromogenic Compounds; Data Interpretation, Statistical; Diabetes Mellitus; Drug Combinations; Enzyme Inhibitors; Fructose; Glucose; Humans; Molsidomine; Nitrates; Oxidants; Plasma; Plasminogen; Streptokinase | 2003 |
Cyclic AMP and cyclic GMP independent stimulation of ventricular calcium current by peroxynitrite donors in guinea pig myocytes.
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Cyclic AMP; Cyclic GMP; Guinea Pigs; Heart Ventricles; Metalloporphyrins; Molsidomine; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Pyrogallol; Superoxide Dismutase; Up-Regulation | 2003 |
In vitro reactive nitrating species toxicity in dissociated spinal motor neurons from NFL (-/-) and hNFL (+/+) transgenic mice.
Topics: Animals; Cell Death; Cells, Cultured; Humans; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molsidomine; Motor Neurons; Neurofilament Proteins; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Peroxynitrous Acid; Spinal Cord; Superoxide Dismutase; Triazenes | 2003 |
Procyanidins from grape seeds protect endothelial cells from peroxynitrite damage and enhance endothelium-dependent relaxation in human artery: new evidences for cardio-protection.
Topics: 6-Ketoprostaglandin F1 alpha; Antioxidants; Biflavonoids; Catechin; Cell Survival; Cells, Cultured; Endothelin-1; Endothelium; Endothelium, Vascular; Fluoresceins; Fluorescent Dyes; Free Radicals; Humans; In Vitro Techniques; Lipid Peroxidation; Mammary Arteries; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Peroxynitrous Acid; Proanthocyanidins; Seeds; Vasoconstriction; Vitis | 2003 |
Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-1alpha.
Topics: Antigens, CD; Cell Differentiation; Cell Division; Cell Hypoxia; Cobalt; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leukemia, Myeloid, Acute; Molsidomine; Transcription Factors; Tumor Cells, Cultured; U937 Cells | 2003 |
Inhibition of peroxynitrite-mediated LDL oxidation by prenylated flavonoids: the alpha,beta-unsaturated keto functionality of 2'-hydroxychalcones as a novel antioxidant pharmacophore.
Topics: Antioxidants; Bicarbonates; Chalcone; Chalcones; Chromatography, High Pressure Liquid; Flavonoids; Humans; Humulus; Lipid Metabolism; Lipid Peroxidation; Lipoproteins, LDL; Magnetic Resonance Spectroscopy; Molecular Structure; Molsidomine; Oxidation-Reduction; Peroxynitrous Acid; Propiophenones; Spectrophotometry | 2003 |
Potent antioxidant properties of 4-hydroxyl-propranolol.
Topics: Animals; Antioxidants; Cell Survival; Cells, Cultured; Drug Interactions; Endothelial Cells; Glutathione; Humans; Hydroxyl Radical; Lipoproteins, LDL; Male; Molsidomine; Oxidation-Reduction; Propranolol; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2004 |
Peroxynitrite decreases dopamine's vasoconstrictive activity.
Topics: Animals; Aorta, Thoracic; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Molsidomine; Muscle Contraction; Muscle, Smooth, Vascular; Peroxynitrous Acid; Rats; Vasoconstriction | 2003 |
Protection by the Chinese prescription Wen-Pi-Tang against renal tubular LLC-PK1 cell damage induced by 3-morpholinosydnonimine.
Topics: Animals; Apoptosis; Cell Culture Techniques; Cell Cycle; DNA Damage; Drugs, Chinese Herbal; Enzyme Inhibitors; Kidney Tubules; LLC-PK1 Cells; Molsidomine; Oxidative Stress; Swine | 2003 |
Role of the nitric oxide/cyclic GMP pathway and ascorbic acid in 3-morpholinosydnonimine (SIN-1)-induced increases in dopamine secretion from PC12 cells. A microdialysis in vitro study.
Topics: Animals; Antioxidants; Ascorbic Acid; Calcium; Calcium Channel Blockers; Cyclic GMP; Dialysis; Dopamine; Drug Interactions; In Vitro Techniques; Molsidomine; Nifedipine; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; PC12 Cells; Potassium; Rats; Signal Transduction; Time Factors | 2003 |
The superoxide dismutase mimetic, tempol, blunts right ventricular hypertrophy in chronic hypoxic rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Administration, Oral; Animals; Body Weight; Chronic Disease; Cyclic N-Oxides; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Endothelin-1; Free Radical Scavengers; Heart Rate; Hypertrophy, Right Ventricular; Hypoxia; Male; Molsidomine; Muscle, Smooth, Vascular; Organ Size; Pulmonary Artery; Rats; Rats, Wistar; Spin Labels; Superoxide Dismutase; Vasoconstriction; Vasodilation; Ventricular Pressure | 2004 |
Nitric oxide and reactive oxygen species exert opposing effects on the stability of hypoxia-inducible factor-1alpha (HIF-1alpha) in explants of human pial arteries.
Topics: Arteries; Enzyme Stability; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Models, Biological; Molsidomine; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Reactive Oxygen Species; RNA, Messenger; S-Nitrosoglutathione; Signal Transduction; Superoxide Dismutase; Superoxides; Transcription Factors; Xanthine; Xanthine Oxidase | 2004 |
Oxidative and adhesive responses of human neutrophils to nitrovasodilators in vitro: the role of protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Adhesion; Cells, Cultured; Enzyme Inhibitors; Genistein; Humans; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitric Oxide Donors; Nitroprusside; Oxidation-Reduction; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Respiratory Burst; Signal Transduction; Tetradecanoylphorbol Acetate; Vasodilator Agents | 2003 |
Peroxynitrite irreversibly inactivates the human xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) in human breast cancer cells: a cellular and mechanistic study.
Topics: Arylamine N-Acetyltransferase; Breast Neoplasms; Cysteine; Dithiothreitol; Enzyme Inhibitors; Glutathione; Humans; Isoenzymes; Kinetics; Molsidomine; Oxidation-Reduction; Peroxynitrous Acid; Recombinant Proteins; Tumor Cells, Cultured | 2004 |
Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels.
Topics: Adolescent; Adult; Aging; Cartilage, Articular; Cell Death; Cell Survival; Chondrocytes; Glutathione; Glutathione Disulfide; Glutathione Reductase; Humans; Insulin-Like Growth Factor I; Middle Aged; Molsidomine; Nitric Oxide Donors; Oxidative Stress; Reactive Oxygen Species; Thioredoxin-Disulfide Reductase | 2003 |
NO/cyclic GMP pathway mediates the relaxation of feline lower oesophageal sphincter.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Esophagogastric Junction; In Vitro Techniques; Indomethacin; Male; Methylene Blue; Molsidomine; Muscle Relaxation; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Signal Transduction; Vasoactive Intestinal Peptide | 2003 |
Reduction in [D-Ala2, NMePhe4, Gly-ol5]enkephalin-induced peripheral antinociception in diabetic rats: the role of the L-arginine/nitric oxide/cyclic guanosine monophosphate pathway.
Topics: Analgesics, Opioid; Animals; Arginine; Blood Glucose; Cyclic GMP; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Formaldehyde; Guanylate Cyclase; Male; Methylene Blue; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Pain; Pain Measurement; Rats; Rats, Wistar | 2004 |
Inactivation of wild-type p53 protein function by reactive oxygen and nitrogen species in malignant glioma cells.
Topics: Cell Line, Tumor; Doxycycline; Glioblastoma; Humans; Molsidomine; Peroxynitrous Acid; Reactive Nitrogen Species; Reactive Oxygen Species; Transcriptional Activation; Transfection; Tumor Suppressor Protein p53 | 2003 |
Modulation of A1 adenosine receptor signaling by peroxynitrite.
Topics: Animals; Central Nervous System; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Rats; Rats, Wistar; Receptor, Adenosine A1; Signal Transduction; Sulfur Radioisotopes; Tritium | 2004 |
Differential antinociceptive effects of L-arginine and 3-morpholinosydoimine.
Topics: Analgesics; Animals; Arginine; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Male; Mice; Molsidomine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement | 2003 |
The role of nitric oxide in locomotor regulation in mice and its interaction with nitrous oxide.
Topics: Animals; Citrulline; Male; Mice; Molsidomine; Motor Activity; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrous Oxide; Thiourea | 2003 |
Participation of the NO-cyclic GMP pathway in rofecoxib-induced antinociception.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Isoenzymes; Lactones; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Pain; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Wistar; Sulfones; Uric Acid | 2003 |
Peroxynitrite-induced apoptosis in photoreceptor cells.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; DNA; Immunohistochemistry; In Situ Nick-End Labeling; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Photoreceptor Cells, Vertebrate; Rats; Rats, Inbred Lew; Uric Acid | 2004 |
Effects of oxygen on the reactivity of nitrogen oxide species including peroxynitrite.
Topics: Anaerobiosis; Electron Spin Resonance Spectroscopy; Glutathione; Molsidomine; Morpholines; Nitric Oxide; Nitrogen Oxides; Nitrosamines; Nitrous Oxide; Oxygen; Peroxynitrous Acid; S-Nitrosoglutathione; Solutions; Tyrosine | 2004 |
A possible defensive mechanism in the basal region of gastric mucosa and the healing of erosions.
Topics: Animals; Burns; Enzyme Inhibitors; Esters; Exudates and Transudates; Gabexate; Gastric Mucosa; Guanidines; Male; Microcirculation; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Wistar; Skin; Stomach Ulcer; Stress, Physiological; Vascular Endothelial Growth Factor A; Venules | 2003 |
Nitric oxide-induced carbonylation of Bcl-2, GAPDH and ANT precedes apoptotic events in insulin-secreting RINm5F cells.
Topics: Adenine Nucleotides; Animals; Apoptosis; Cell Nucleus; Cells, Cultured; Cytoplasm; DEET; Free Radical Scavengers; Glyceraldehyde-3-Phosphate Dehydrogenases; Insulin; Insulin Secretion; Interleukin-1; Kinetics; Lipid Peroxidation; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Proto-Oncogene Proteins c-bcl-2; Rats; Superoxide Dismutase | 2004 |
Role of cyclic GMP on inhibition by nitric oxide donors of human eosinophil chemotaxis in vitro.
Topics: Adolescent; Adult; Blotting, Western; Cell Survival; Chemotaxis, Leukocyte; Cyclic GMP; Eosinophils; Female; Humans; In Vitro Techniques; Male; Middle Aged; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Nitric Oxide Donors; Nitroprusside; Penicillamine; Tetrazolium Salts; Thiazoles; Tyrosine | 2004 |
Involvement of the mitogen-activated protein kinase cascade in peroxynitrite-mediated arachidonic acid release in vascular smooth muscle cells.
Topics: Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chelating Agents; Dinoprostone; Enzyme Inhibitors; Group IV Phospholipases A2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Phospholipases A; Rats | 2004 |
A common pathway of nitric oxide release from AZD3582 and glyceryl trinitrate.
Topics: Animals; Cyclic GMP; Cyclooxygenase Inhibitors; LLC-PK1 Cells; Molsidomine; Naphthalenes; Naproxen; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Swine | 2004 |
Xanthine oxidase converts nitric oxide to nitroxyl that inactivates the enzyme.
Topics: Animals; Cattle; Dose-Response Relationship, Drug; Hemoglobins; Molsidomine; Nitric Oxide; Nitrites; Nitrogen Oxides; Oxygen; Peroxynitrous Acid; Protein Binding; Reactive Nitrogen Species; Spermine; Xanthine; Xanthine Oxidase | 2004 |
Mutations in the extracellular loop of alpha-rENaC alter sensitivity to amiloride and reactive species.
Topics: Amiloride; Animals; Diuretics; Epithelial Sodium Channels; Molsidomine; Mutation; Oocytes; Patch-Clamp Techniques; Peroxynitrous Acid; Reactive Oxygen Species; RNA, Messenger; Sodium Channels; Xenopus laevis | 2004 |
Peroxynitrite decreases rabbit tissue factor activity in vitro.
Topics: Animals; Blood Coagulation; Brain Chemistry; Humans; In Vitro Techniques; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Rabbits; Reperfusion Injury; Superoxide Dismutase; Superoxides; Thrombelastography; Thromboplastin | 2004 |
3-Morpholinosyndnonimine inhibits 5-hydroxytryptamine-induced phosphorylation of nitric oxide synthase in endothelial cells.
Topics: Animals; Cattle; Dose-Response Relationship, Drug; Endothelium, Vascular; Feedback, Physiological; Molsidomine; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Phosphorylation; Serotonin; Serotonin Antagonists | 2003 |
High and low gain switches for regulation of cAMP efflux concentration: distinct roles for particulate GC- and soluble GC-cGMP-PDE3 signaling in rabbit atria.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Animals; Atrial Natriuretic Factor; Biological Transport; Cardiac Pacing, Artificial; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Inhibitors; Guanylate Cyclase; Heart Atria; Milrinone; Molsidomine; Myocardial Contraction; Myocytes, Cardiac; Natriuretic Peptide, C-Type; Nitric Oxide Donors; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazoles; Pyridines; Quinoxalines; Rabbits; Receptors, Cytoplasmic and Nuclear; Second Messenger Systems; Soluble Guanylyl Cyclase; Stroke Volume | 2004 |
Decomposition mechanism of 3-N-morpholinosydnonimine (SIN-1)--a density functional study on intrinsic structures and reactivities.
Topics: Hydrogen-Ion Concentration; Models, Chemical; Models, Molecular; Molecular Conformation; Molsidomine; Thermodynamics | 2004 |
Nitric oxide and superoxide impair human placental amino acid uptake and increase Na+ permeability: implications for fetal growth.
Topics: Amino Acids; Biological Transport; Female; Fetal Growth Retardation; Free Radicals; Humans; Infant, Newborn; Microvilli; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Placenta; Pregnancy; Sodium; Subcellular Fractions; Superoxides; Time Factors; Trophoblasts; Tyrosine | 2004 |
Nitric oxide inhibits DNA-adduct excision in nucleotide excision repair.
Topics: 4-Nitroquinoline-1-oxide; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Alkylating Agents; Arsenites; Cell Nucleus; Cisplatin; Comet Assay; DNA; DNA Adducts; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Fibroblasts; Humans; Mitomycin; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Plasmids; Time Factors; Ultraviolet Rays | 2004 |
Overexpression of alpha-synuclein decreased viability and enhanced sensitivity to prostaglandin E(2), hydrogen peroxide, and a nitric oxide donor in differentiated neuroblastoma cells.
Topics: alpha-Synuclein; Animals; Cell Differentiation; Cell Survival; Dinoprostone; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Mice; Molsidomine; Nerve Tissue Proteins; Neuroblastoma; Nitric Oxide Donors; Synucleins; Transfection; Tumor Cells, Cultured | 2004 |
Potent inhibition of peroxynitrite-induced DNA strand breakage by ethanol: possible implications for ethanol-mediated cardiovascular protection.
Topics: Bacteriophage phi X 174; Bicarbonates; Central Nervous System Depressants; DNA Damage; DNA, Viral; Ethanol; Heart Diseases; Molsidomine; Oxidation-Reduction; Oxygen Consumption; Peroxynitrous Acid; Plasmids; Rhodamines | 2004 |
17beta-estradiol protects oligodendrocytes from cytotoxicity induced cell death.
Topics: Animals; Cell Compartmentation; Cell Death; Cell Division; Cell Nucleus; Cells, Cultured; Cytoprotection; Cytosol; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Fulvestrant; L-Lactate Dehydrogenase; Male; Molsidomine; Nitric Oxide Donors; Oligodendroglia; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; RNA, Messenger | 2004 |
Peroxynitrite inactivates tissue plasminogen activator.
Topics: Antioxidants; Blotting, Western; Dose-Response Relationship, Drug; Humans; Molsidomine; Nitric Oxide; Peroxynitrous Acid; Recombinant Proteins; Superoxide Dismutase; Superoxides; Thrombelastography; Tissue Plasminogen Activator | 2004 |
Elements of the nitric oxide pathway can degrade TIMP-1 and increase gelatinase activity.
Topics: Adult; Blotting, Northern; Blotting, Western; Cells, Cultured; Corneal Stroma; Fibroblasts; Gelatinases; Humans; Middle Aged; Molsidomine; Nitric Oxide; Nitric Oxide Donors; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Tissue Inhibitor of Metalloproteinase-1; Up-Regulation | 2004 |
Comparison of toxic effects of nitric oxide and peroxynitrite on Uronema marinum (Ciliata: Scuticociliatida).
Topics: Animals; Catalase; Ciliophora; Dose-Response Relationship, Drug; Hemoglobins; Molsidomine; Nitric Oxide Donors; Penicillamine; Superoxide Dismutase | 2004 |
Effects of phosphodiesterase V inhibition on nitric oxide-mediated relaxation responses in guinea pig trachea.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Arginine; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Electric Stimulation; Electrodes; Guinea Pigs; Histamine; Isomerism; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Trachea | 2004 |
Endothelium-dependent relaxation of canine pulmonary artery after prolonged lung graft preservation in University of Wisconsin solution: role of L-arginine supplementation.
Topics: Acetylcholine; Adenosine; Adenosine Diphosphate; Allopurinol; Animals; Arginine; Dogs; Endothelium, Vascular; Female; Glutathione; Insulin; Lung; Lung Transplantation; Male; Molsidomine; omega-N-Methylarginine; Organ Preservation Solutions; Pulmonary Artery; Raffinose; Sodium Fluoride; Tissue Preservation | 2004 |
An extracellular signal-regulated kinase 1- and 2-dependent program of chromatin trafficking of c-Fos and Fra-1 is required for cyclin D1 expression during cell cycle reentry.
Topics: Animals; Cell Cycle; Chromatin; Cyclin D1; Enzyme Inhibitors; Hydrogen Peroxide; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molsidomine; Oxidants; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fos | 2004 |
Nitric oxide activates glibenclamide-sensitive K+ channels in urinary bladder myocytes through a c-GMP-dependent mechanism.
Topics: Adenosine Triphosphate; Animals; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Glyburide; Guinea Pigs; Indoles; Ion Channel Gating; Male; Membrane Potentials; Molsidomine; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Patch-Clamp Techniques; Potassium Channels; Quinoxalines; Signal Transduction; Urinary Bladder | 2004 |
Dual role for poly(ADP-ribose)polymerase-1 and -2 and poly(ADP-ribose)glycohydrolase as DNA-repair and pro-apoptotic factors in rat germinal cells exposed to nitric oxide donors.
Topics: Animals; Apoptosis; Benzamides; Blotting, Western; DNA Damage; DNA Repair; Enzyme Activation; Germ Cells; Glycoside Hydrolases; Hydrolyzable Tannins; In Situ Nick-End Labeling; Male; Molsidomine; Nitric Oxide Donors; Nitrogen Oxides; Oxidative Stress; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Rats; Spermatids; Spermatocytes; Spermine; Time Factors | 2004 |
Increased release of excitatory amino acids by the actions of ATP and peroxynitrite on volume-regulated anion channels (VRACs) in astrocytes.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Astrocytes; Cell Size; Cells, Cultured; Culture Media; Excitatory Amino Acids; Ion Channels; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Osmolar Concentration; Peroxynitrous Acid; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley | 2004 |
Vasodilatory effects of cholinergic agonists are greatly diminished in aorta from M3R-/- mice.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Aorta, Thoracic; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Endothelium, Vascular; Male; Mice; Mice, Knockout; Molsidomine; Muscle, Smooth, Vascular; Phenylephrine; Receptor, Muscarinic M3; Vasoconstriction; Vasodilation | 2004 |
Inhibition of SIN-1-induced change in mitochondrial membrane permeability in PC12 cells by dopamine.
Topics: Animals; Apoptosis; Cell Death; Cell Survival; Cytochromes c; Dopamine; Intracellular Membranes; Mitochondria; Molsidomine; PC12 Cells; Permeability; Rats | 2004 |
Effect of L-ascorbic acid on the oxidative modification of apolipoprotein E in human very-low-density lipoprotein.
Topics: Amidines; Antioxidants; Apolipoproteins E; Ascorbic Acid; Heparin; Humans; Lipid Peroxidation; Lipoproteins, VLDL; Molsidomine; Oxidants; Peroxides; Peroxynitrous Acid | 2004 |
Reduction of insulin-stimulated glucose uptake by peroxynitrite is concurrent with tyrosine nitration of insulin receptor substrate-1.
Topics: 3T3-L1 Cells; Animals; Binding Sites; Dose-Response Relationship, Drug; Glucose; Insulin; Insulin Receptor Substrate Proteins; Mice; Molsidomine; Nitrates; Peroxynitrous Acid; Phosphoproteins; Protein Binding; Rats; Tyrosine | 2004 |
Protective properties of neoechinulin A against SIN-1-induced neuronal cell death.
Topics: Alkaloids; Animals; Antioxidants; Apoptosis; Caspase 3; Caspases; Dose-Response Relationship, Drug; Molsidomine; Neurons; Oxidative Stress; PC12 Cells; Peroxynitrous Acid; Piperazines; Rats; Reactive Oxygen Species | 2004 |
Benzodiazepine receptor and serotonin 2A receptor modulate the aversive-like effects of nitric oxide in the dorsolateral periaqueductal gray of rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Electric Stimulation; GABA Agonists; GABA Modulators; Male; Microinjections; Midazolam; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Periaqueductal Gray; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, GABA-A; Reinforcement, Psychology; Serotonin Agents; Serotonin Receptor Agonists; Stereotaxic Techniques | 2004 |
Peroxynitrite decreases hemostasis in human plasma in vitro.
Topics: Blood Coagulation Factors; Blotting, Western; Coagulants; Dose-Response Relationship, Drug; Factor X; Hemostasis; Humans; In Vitro Techniques; Molsidomine; Nitric Oxide Donors; Partial Thromboplastin Time; Peroxynitrous Acid; Plasma; Protein C; Prothrombin Time; Superoxide Dismutase; Thrombelastography; Tyrosine | 2004 |
Nitric oxide attenuates cardiomyocytic apoptosis via diminished mitochondrial complex I up-regulation from cardiac ischemia-reperfusion injury under cardiopulmonary bypass.
Topics: Animals; Apoptosis; Cardiopulmonary Bypass; Dogs; Electron Transport Complex I; Molsidomine; Myocardial Reperfusion Injury; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Up-Regulation | 2004 |
Nitroprusside stimulates mitochondrial aconitase gene expression through the cyclic adenosine 3',5'-monosphosphate signal transduction pathway in human prostate carcinoma cells.
Topics: Aconitate Hydratase; Ascorbic Acid; Blotting, Western; Cell Line, Tumor; Cyclic AMP; Free Radical Scavengers; Gene Expression; Humans; Male; Molsidomine; Nitric Oxide Donors; Nitroprusside; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; S-Nitroso-N-Acetylpenicillamine; Signal Transduction | 2004 |
GEA 3162 decomposes to co-generate nitric oxide and superoxide and induces apoptosis in human neutrophils via a peroxynitrite-dependent mechanism.
Topics: Apoptosis; Cell Separation; Electrochemistry; Electron Spin Resonance Spectroscopy; Fluorescent Dyes; Humans; In Vitro Techniques; Molsidomine; Neutrophils; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Rhodamines; Superoxides; Triazoles | 2004 |
Effects of L-arginine and SIN-1 on sleep and waking in the rat during both phases of the light-dark cycle.
Topics: Analysis of Variance; Animals; Arginine; Central Nervous System; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Male; Molsidomine; Nitric Oxide; Photoperiod; Rats; Sleep; Time Factors | 2004 |
Cell type-dependent release of nitric oxide and/or reactive nitrogenoxide species from intracellular SIN-1: effects on cellular NAD(P)H.
Topics: Animals; Cattle; Cell Line; Endothelial Cells; Fibroblasts; Free Radicals; Mice; Molecular Structure; Molsidomine; NADP; Nitric Oxide; Nitrogen Dioxide; Time Factors | 2004 |
15-Deoxy-Delta12,14-prostaglandin J(2) protects against nitrosative PC12 cell death through up-regulation of intracellular glutathione synthesis.
Topics: Animals; Apoptosis; Cyclooxygenase 2; DNA-Binding Proteins; Glutamate-Cysteine Ligase; Glutathione; Isoenzymes; Molsidomine; Neuroprotective Agents; NF-E2-Related Factor 2; PC12 Cells; PPAR gamma; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rats; Trans-Activators; Up-Regulation | 2004 |
3-Morpholinylsydnonimine inhibits glutamatergic transmission in rat rostral ventrolateral medulla via peroxynitrite formation and adenosine release.
Topics: Adenosine; Animals; Calcium Channels, N-Type; Glutamic Acid; In Vitro Techniques; Male; Medulla Oblongata; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2004 |
Nitroaspirins and morpholinosydnonimine but not aspirin inhibit the formation of superoxide and the expression of gp91phox induced by endotoxin and cytokines in pig pulmonary artery vascular smooth muscle cells and endothelial cells.
Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Evaluation, Preclinical; Endothelial Cells; Endothelium, Vascular; Enzyme Induction; Epoprostenol; Glycoproteins; Guanylate Cyclase; Interleukin-1; Lipopolysaccharides; Male; Molsidomine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Onium Compounds; Pulmonary Artery; Respiratory Distress Syndrome; Superoxides; Sus scrofa; Tumor Necrosis Factor-alpha | 2004 |
Role of anions in nitric oxide-induced short-circuit current increase in isolated porcine ciliary processes.
Topics: Animals; Anion Transport Proteins; Anions; Aqueous Humor; Carbonic Anhydrase Inhibitors; Chloride Channels; Ciliary Body; Corneal Stroma; Cyclic GMP; Electric Conductivity; Enzyme Inhibitors; Guanylate Cyclase; Ion Exchange; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Protein Kinase Inhibitors; Swine; Thionucleotides | 2004 |
Insulin sensitivity is mediated by the activation of the ACh/NO/cGMP pathway in rat liver.
Topics: Acetylcholine; Animals; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Injections, Intravenous; Insulin Resistance; Liver; Male; Molsidomine; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Portal Vein; Quinoxalines; Rats; Rats, Wistar; Signal Transduction | 2004 |
Peroxynitrite alters the catalytic activity of rodent liver proteasome in vitro and in vivo.
Topics: Animals; Catalysis; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Liver; Mice; Mice, Inbred C57BL; Molsidomine; Multienzyme Complexes; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Rats; S-Nitroso-N-Acetylpenicillamine | 2004 |
PKC downstream of Pl3-kinase regulates peroxynitrite formation for Nrf2-mediated GSTA2 induction.
Topics: Animals; Cell Line; Chromones; DNA-Binding Proteins; Enzyme Activation; Glutathione Transferase; Hepatocytes; Hydroquinones; Immunoblotting; Molsidomine; Morpholines; NF-E2-Related Factor 2; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Protein Kinase C; Rats; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Trans-Activators | 2004 |
Interference of 7,8-dihydroneopterin with peroxynitrite-mediated reactions.
Topics: Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Hydroxylation; Luminescent Measurements; Molsidomine; Neopterin; Oxidation-Reduction; Peroxynitrous Acid; Piperidines; Salicylic Acid; Spectrometry, Fluorescence; Superoxides; Tyrosine | 2004 |
Highly selective and prolonged depletion of mitochondrial glutathione in astrocytes markedly increases sensitivity to peroxynitrite.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Brain; Cell Death; Cells, Cultured; Citrate (si)-Synthase; Cyclosporine; Cytoplasm; Electron Transport; Electron Transport Complex I; Ethacrynic Acid; Glutathione; Intracellular Membranes; L-Lactate Dehydrogenase; Membrane Potentials; Mitochondria; Molsidomine; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley | 2004 |
Pro-oxidant properties and cytotoxicity of AZT-monophosphate and AZT.
Topics: Animals; Aorta; Cattle; Cell Survival; Cells, Cultured; Dideoxynucleotides; Endothelial Cells; Endothelium, Vascular; Free Radicals; Glutathione; In Vitro Techniques; Intracellular Membranes; Lipid Peroxidation; Magnesium; Microsomes, Liver; Molsidomine; Oxidants; Oxidative Stress; Rats; Rats, Sprague-Dawley; Thymidine; Thymine Nucleotides; Zidovudine | 2004 |
Signalling pathways in the nitric oxide donor-induced dopamine release in the striatum of freely moving rats: evidence that exogenous nitric oxide promotes Ca2+ entry through store-operated channels.
Topics: Animals; Boron Compounds; Calcium; Chelating Agents; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Drug Interactions; Egtazic Acid; Electrochemistry; Functional Laterality; Male; Microdialysis; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Quinoxalines; Rats; Rats, Wistar; S-Nitrosoglutathione; Signal Transduction; Wakefulness | 2004 |
Caspase-1 and poly (ADP-ribose) polymerase inhibitors may protect against peroxynitrite-induced neurotoxicity independent of their enzyme inhibitor activity.
Topics: Adenosine Triphosphate; Amino Acid Chloromethyl Ketones; Animals; Caspase Inhibitors; Cells, Cultured; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Kinetics; Molsidomine; Neurons; Peroxynitrous Acid; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley | 2004 |
Calcium mobilization is required for peroxynitrite-mediated enhancement of spontaneous transient outward currents in arteriolar smooth muscle cells.
Topics: Animals; Boron Compounds; Caffeine; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; Female; Male; Membrane Potentials; Models, Biological; Molsidomine; Muscle, Smooth; Myocytes, Smooth Muscle; Nifedipine; Patch-Clamp Techniques; Peroxynitrous Acid; Potassium; Rats; Rats, Wistar; Ryanodine; Signal Transduction; Time Factors | 2004 |
The sin in the aetiological concept of Johann Christian August Heinroth (1773-1843). Part 1: Between theology and psychiatry. Heinroth's concepts of 'whose being', 'freedom', 'reason' and 'disturbance of the soul'.
Topics: Germany; History, 18th Century; History, 19th Century; Holistic Health; Mental Disorders; Molsidomine; Psychiatry; Theology | 2004 |
Intracellular pH-dependent peroxynitrite-evoked synergistic death of glucose-deprived astrocytes.
Topics: Amiloride; Ammonium Chloride; Anaerobiosis; Animals; Astrocytes; Brain Ischemia; Caspases; Cyclosporine; Glucose; Glutathione; Hydrogen-Ion Concentration; Intracellular Fluid; Intracellular Membranes; L-Lactate Dehydrogenase; Membrane Potentials; Mitochondria; Molsidomine; Oxidation-Reduction; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Sodium Acetate; Sodium-Hydrogen Exchangers | 2004 |
Heme oxygenase-1 mediates up-regulation of adhesion molecule expression induced by peroxynitrite in endothelial cells.
Topics: Cell Adhesion Molecules; Cells, Cultured; E-Selectin; Endothelial Cells; Gene Expression; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Membrane Proteins; Molsidomine; Nitric Oxide Donors; Oxidative Stress; P-Selectin; Peroxynitrous Acid; RNA, Messenger; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 2004 |
No hemoglobin but NO: the icefish (Chionodraco hamatus) heart as a paradigm.
Topics: Animals; Antarctic Regions; Arginine; Cardiotonic Agents; Cell Respiration; Cyclic GMP; Electrochemistry; Fluorescent Antibody Technique; Molsidomine; Myocardial Contraction; Myocardium; NADH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oceans and Seas; Ornithine; Perciformes | 2004 |
alpha-keto-beta-methyl-n-valeric acid diminishes reactive oxygen species and alters endoplasmic reticulum Ca(2+) stores.
Topics: Alzheimer Disease; Animals; Apoptosis; Calcium; Cell Line; Endoplasmic Reticulum; Fluoresceins; Free Radical Scavengers; Glucose; Humans; Hydrogen Peroxide; Keto Acids; Molsidomine; Oxidative Stress; Oxygen; Rats; Reactive Oxygen Species | 2004 |
Protecting against peroxynitrite-mediated cytotoxicity in vascular smooth muscle cells via upregulating endogenous glutathione biosynthesis by 3H-1,2-dithiole-3-thione.
Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Drug Antagonism; Drug Combinations; Glutathione; Molsidomine; Muscle, Smooth, Vascular; Peroxynitrous Acid; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiones; Thiophenes; Up-Regulation | 2004 |
Protective effect of 1-methylated beta-carbolines against 3-morpholinosydnonimine-induced mitochondrial damage and cell viability loss in PC12 cells.
Topics: Animals; Carbolines; Cell Survival; Mitochondria; Molsidomine; PC12 Cells; Rats | 2004 |
Reactivity of 1,4-dihydropyridines toward SIN-1-derived peroxynitrite.
Topics: Deuterium; Dihydropyridines; Electron Spin Resonance Spectroscopy; Gas Chromatography-Mass Spectrometry; Indicators and Reagents; Kinetics; Magnetic Resonance Spectroscopy; Molsidomine; Oxidation-Reduction; Peroxynitrous Acid; Solutions; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared | 2004 |
Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Arachidonate 12-Lipoxygenase; Caspase 3; Caspases; Cells, Cultured; Chelating Agents; Enzyme Activation; Ethylenediamines; Free Radicals; Glutathione; Membrane Potentials; Microscopy, Fluorescence; Mitochondria; Molsidomine; Neurons; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Rats; Spectrometry, Fluorescence; Zinc | 2004 |
Propofol attenuates peroxynitrite-mediated DNA damage and apoptosis in cultured astrocytes: an alternative protective mechanism.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Astrocytes; Blotting, Western; Caspase 3; Caspases; Cells, Cultured; Comet Assay; DNA; DNA Damage; Enzyme Activation; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; L-Lactate Dehydrogenase; Molsidomine; Oxidative Stress; Peroxynitrous Acid; Propofol; Rats; Rats, Wistar; Tetrazolium Salts; Thiazoles | 2004 |
[Effects of nitric oxide donor on autoimmune myasthenia gravis in rats].
Topics: Animals; Female; Molsidomine; Myasthenia Gravis; Nitric Oxide Donors; Rats; Rats, Inbred Lew; Receptors, Cholinergic; Th1 Cells; Th2 Cells | 2004 |
Parasite killing in Plasmodium vivax malaria by nitric oxide: implication of aspartic protease inhibition.
Topics: Animals; Aspartic Acid; Aspartic Acid Endopeptidases; Catalase; Catalytic Domain; Chromatography, High Pressure Liquid; Cysteine; Dithiothreitol; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Gelatin; Glutamate Dehydrogenase (NADP+); Glutathione; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Malaria, Vivax; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Pepsin A; Pepstatins; Plasmodium; Plasmodium vivax; Protease Inhibitors; Reactive Nitrogen Species; S-Nitrosoglutathione; Time Factors; Up-Regulation | 2004 |
Fluorescence measurements of steady state peroxynitrite production upon SIN-1 decomposition: NADH versus dihydrodichlorofluorescein and dihydrorhodamine 123.
Topics: Fluoresceins; Molsidomine; NAD; Peroxynitrous Acid; Rhodamines; Spectrometry, Fluorescence | 2004 |
Effects of endogenous and exogenous nitric oxide on electrical responses of circular smooth muscle isolated from the guinea-pig stomach antrum.
Topics: Action Potentials; Animals; Electromyography; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Male; Molsidomine; Muscle, Smooth; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Pyloric Antrum | 2004 |
Nitric oxide stimulates gamma-aminobutyric acid release and inhibits glycine release in retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Cadmium; Citrulline; Cyclic GMP; DEET; Dizocilpine Maleate; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Free Radical Scavengers; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Immunohistochemistry; In Vitro Techniques; Molsidomine; Neural Inhibition; Nipecotic Acids; Nitric Oxide; Potassium; Retina; Silver Staining; Thiourea; Turtles; Vigabatrin | 2005 |
Alteration of cytosolic free calcium homeostasis by SIN-1: high sensitivity of L-type Ca2+ channels to extracellular oxidative/nitrosative stress in cerebellar granule cells.
Topics: Animals; Calcium; Calcium Channels, L-Type; Cell Survival; Cells, Cultured; Cerebellum; Cytosol; Dose-Response Relationship, Drug; Homeostasis; Molsidomine; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar | 2005 |
The effects of intraspinal L-NOARG or SIN-1 on the control by descending pathways of incisional pain in rats.
Topics: Analgesia; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Efferent Pathways; Electric Stimulation; Enzyme Inhibitors; Hindlimb; Injections, Spinal; Male; Mesencephalon; Molsidomine; Nitric Oxide Donors; Nitroarginine; Pain; Pain Threshold; Raphe Nuclei; Rats; Rats, Wistar; Spinal Cord | 2005 |
Inhibition of MG132-induced mitochondrial dysfunction and cell death in PC12 cells by 3-morpholinosydnonimine.
Topics: Animals; Antioxidants; Cell Death; Cell Membrane Permeability; Cysteine Proteinase Inhibitors; Cytochromes c; Dose-Response Relationship, Drug; Energy Metabolism; Enzyme Inhibitors; Free Radicals; Glutathione; Leupeptins; Mitochondria; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Oxidative Stress; PC12 Cells; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Superoxides | 2005 |
Lack of synergistic effect of molsidomine and sildenafil on development of pulmonary hypertension in chronic hypoxic rats.
Topics: Acetylcholine; Actins; Animals; Atrial Natriuretic Factor; Body Weight; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Guanylate Cyclase; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Lung; Male; Molsidomine; Muscle, Smooth; Oxadiazoles; Piperazines; Pulmonary Artery; Purines; Quinoxalines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones; Systole; Vasodilation; Vasodilator Agents | 2005 |
Curcumin overcomes the inhibitory effect of nitric oxide on Leishmania.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Leishmania donovani; Leishmania major; Mice; Mice, Inbred BALB C; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Penicillamine; Peroxynitrous Acid | 2005 |
Protective role of Coptidis Rhizoma alkaloids against peroxynitrite-induced damage to renal tubular epithelial cells.
Topics: Alkaloids; Animals; Cell Survival; Coptis chinensis; DNA Fragmentation; Drugs, Chinese Herbal; Kidney Tubules; LLC-PK1 Cells; Molecular Structure; Molsidomine; Peroxynitrous Acid; Swine; Urothelium | 2005 |
Hemorrhagic shock resuscitation affects early and selective mesenteric artery endothelial function through a free radical-dependent mechanism.
Topics: Acetylcholine; Animals; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascular; Free Radical Scavengers; Free Radicals; Hemodynamics; Inflammation; Male; Mesenteric Arteries; Molsidomine; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Phenylephrine; Rats; Rats, Wistar; Reperfusion Injury; Resuscitation; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Shock, Hemorrhagic; Tumor Necrosis Factor-alpha; Vasodilation | 2005 |
New glycosidase activated nitric oxide donors: glycose and 3-morphorlinosydnonimine conjugates.
Topics: Catalysis; Glycoside Hydrolases; Glycosides; Models, Molecular; Molecular Structure; Molsidomine; Nitric Oxide Donors; Prodrugs | 2005 |
Peroxynitrite provides the peroxide tone for PGHS-2-dependent prostacyclin synthesis in vascular smooth muscle cells.
Topics: Animals; Cattle; Cells, Cultured; Cyclooxygenase 2; Epoprostenol; Hydrogen Peroxide; Molsidomine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Synthase; Nitrogen Oxides; Peroxynitrous Acid; Spermine; Superoxides | 2005 |
Novel chemiluminescence-inducing cocktails, part I: the role in light emission of combinations of luminal with SIN-1, selenite, albumin, glucose oxidase and Co2+.
Topics: Antioxidants; Cobalt; Electron Spin Resonance Spectroscopy; Glucose Oxidase; Light; Luminescent Measurements; Luminol; Molsidomine; Serum Albumin, Bovine; Sodium Selenite; Tellurium | 2004 |
Novel chemiluminescence-inducing cocktails, part II: measurement of the anti-oxidant capacity of vitamins, thiols, body fluids, alcoholic beverages and edible oils.
Topics: Alcoholic Beverages; Antioxidants; Body Fluids; Dietary Fats, Unsaturated; Glucose Oxidase; Humans; Luminescent Measurements; Luminol; Molsidomine; Sodium Selenite; Sulfhydryl Compounds; Vitamins | 2004 |
Protein phosphatase 1alpha is tyrosine-phosphorylated and inactivated by peroxynitrite in erythrocytes through the src family kinase fgr.
Topics: Down-Regulation; Enzyme Activation; Erythrocytes; Humans; K Cl- Cotransporters; Molsidomine; Peroxynitrous Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-hck; src-Family Kinases; Symporters; Tyrosine | 2005 |
Peroxynitrite-mediated matrix metalloproteinase-2 activation in human hepatic stellate cells.
Topics: Cell Line; Collagenases; Enzyme Activation; Hepatocytes; Humans; I-kappa B Proteins; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Matrix Metalloproteinase 2; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Mitogen-Activated Protein Kinases; Molsidomine; NF-kappa B; NF-KappaB Inhibitor alpha; Nitrates; Penicillamine; Peroxynitrous Acid; Phosphorylation; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1 | 2005 |
Interstitial telomeric DNA sequences of Chinese hamster cells are hypersensitive to nitric oxide damage, and DNA-PKcs has a specific local role in its repair.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; DNA Damage; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; In Situ Hybridization, Fluorescence; Methylnitronitrosoguanidine; Molsidomine; Nitric Oxide Donors; Oligonucleotide Array Sequence Analysis | 2005 |
Deoxycholyltaurine-induced vasodilation of rodent aorta is nitric oxide- and muscarinic M(3) receptor-dependent.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Aorta, Thoracic; Bile Acids and Salts; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Genotype; In Vitro Techniques; Lithocholic Acid; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M3; Taurodeoxycholic Acid; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2005 |
Effects of nitric oxide donors on cybrids harbouring the mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) A3243G mitochondrial DNA mutation.
Topics: Adenosine Triphosphate; Cell Death; Cell Survival; DNA, Mitochondrial; Humans; Hybrid Cells; MELAS Syndrome; Molsidomine; Mutation; Nitric Oxide Donors; Nitroprusside; Reactive Nitrogen Species; Reactive Oxygen Species; Triazenes | 2005 |
Adenosine/nitric oxide crosstalk in the branchial circulation of Squalus acanthias and Anguilla anguilla.
Topics: Adenosine; Anguilla; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Female; Hypoxia; In Vitro Techniques; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Perfusion; Pressure; Signal Transduction; Squalus acanthias; Time Factors; Vasodilation | 2005 |
Involvement of guanylyl cyclase, protein kinase A and Na+ K+ ATPase in relaxations of bovine isolated bronchioles induced by GEA 3175, an NO donor.
Topics: Animals; Bronchi; Calcium; Cattle; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Guanylate Cyclase; In Vitro Techniques; Molsidomine; Muscle Relaxation; Nitric Oxide; Nitric Oxide Donors; Ouabain; Oxadiazoles; Peptides; Potassium; Quinoxalines; S-Nitrosoglutathione; Serotonin; Sodium-Potassium-Exchanging ATPase; Thionucleotides; Triazoles | 2006 |
Flow cytometric evaluation of human neutrophil apoptosis during nitric oxide generation in vitro: the role of exogenous antioxidants.
Topics: Antioxidants; Apoptosis; Catalase; Flow Cytometry; Humans; Molsidomine; Neutrophils; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Superoxide Dismutase; Triazoles | 2005 |
Cardiotrophin-1 protects cortical neuronal cells against free radical-induced injuries in vitro.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Cerebral Infarction; Cytokines; Dose-Response Relationship, Drug; Ferric Compounds; Free Radical Scavengers; Free Radicals; Molsidomine; Neurons; Neuroprotective Agents; Oxidative Stress; Rats | 2005 |
Increased nuclear factor-erythroid 2 p45-related factor 2 activity protects SH-SY5Y cells against oxidative damage.
Topics: 1-Methyl-4-phenylpyridinium; Blotting, Western; Cell Survival; DNA-Binding Proteins; Genes, Reporter; Humans; Hydroquinones; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Luciferases; Molsidomine; NF-E2-Related Factor 2; Oxidative Stress; Oxidopamine; Plasmids; Proteins; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Trans-Activators | 2005 |
Impairment of the activity of the xenobiotic-metabolizing enzymes arylamine N-acetyltransferases 1 and 2 (NAT1/NAT2) by peroxynitrite in mouse skeletal muscle cells.
Topics: Acetyl Coenzyme A; Acetyltransferases; Amino Acid Transport System A; Amino Acid Transport Systems; Animals; Arylamine N-Acetyltransferase; Cell Line; Glutathione; Humans; Isoenzymes; Mice; Molsidomine; Muscle Fibers, Skeletal; Muscle, Skeletal; Nitric Oxide Donors; Peroxynitrous Acid; Xenobiotics | 2005 |
Adenosine and purine nucleosides prevent the disruption of mitochondrial transmembrane potential by peroxynitrite in rat primary astrocytes.
Topics: Adenosine; Animals; Astrocytes; Brain Ischemia; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Glucose; Intracellular Membranes; Membrane Potentials; Mitochondria; Molsidomine; Peroxynitrous Acid; Purine Nucleosides; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase | 2005 |
Angiotensin II induces tyrosine nitration and activation of ERK1/2 in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molsidomine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; Nitrates; Nitric Oxide Synthase; Rats; Receptor, Angiotensin, Type 1; Tyrosine | 2005 |
Delta opioid agonists attenuate TAT(1-72)-induced oxidative stress in SK-N-SH cells.
Topics: Benzamides; Cell Line, Tumor; Cell Membrane; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Fluoresceins; Free Radicals; Gene Products, tat; Humans; Molsidomine; Naltrexone; Narcotic Antagonists; Opioid Peptides; Oxidative Stress; Piperazines; Receptors, Opioid, delta; tat Gene Products, Human Immunodeficiency Virus | 2006 |
Mitogen-activated protein kinases (MAPKs) mediate SIN-1/ glucose deprivation-induced death in rat primary astrocytes.
Topics: Adenosine Triphosphate; Animals; Anthracenes; Astrocytes; Brain Ischemia; Cell Culture Techniques; Cell Death; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glucose; Imidazoles; L-Lactate Dehydrogenase; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Molsidomine; Nitric Oxide Donors; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Pyridines; Rats; Rats, Sprague-Dawley | 2005 |
The importance of the phagocytes' innate response in resolution of the infection induced by a low virulent Candida albicans mutant.
Topics: Animals; Candida albicans; Candidiasis; Cells, Cultured; Fungal Proteins; Guanidines; Immunity, Innate; Interferon-gamma; Interleukin-4; Macrophages, Peritoneal; Mice; Mitogen-Activated Protein Kinases; Molsidomine; Mutation; Neutropenia; Neutrophils; Nitric Oxide; Nitric Oxide Donors; T-Lymphocytes; Virulence | 2005 |
Propofol inhibits caspase-3 in astroglial cells: role of heme oxygenase-1.
Topics: Animals; Antioxidants; Astrocytes; Blotting, Western; Caspase 3; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Enzyme Activation; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Propofol; Rats; Rats, Wistar | 2005 |
Role of endogenous melatonin in the oxidative homeostasis of the extracellular striatal compartment: a microdialysis study in PC12 cells in vitro and in the striatum of freely moving rats.
Topics: Animals; Corpus Striatum; Dehydroascorbic Acid; Dopamine; Homeostasis; Light; Male; Melatonin; Microdialysis; Molsidomine; PC12 Cells; Peroxynitrous Acid; Rats; Rats, Wistar | 2005 |
Peroxynitrite causes endoplasmic reticulum stress and apoptosis in human vascular endothelium: implications in atherogenesis.
Topics: Animals; Aorta; Apolipoproteins E; Apoptosis; Atherosclerosis; Calcium; Cells, Cultured; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endothelium, Vascular; Female; Homeostasis; Humans; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; Superoxides; Tyrosine; Umbilical Veins | 2005 |
Estrogen attenuates gp120- and tat1-72-induced oxidative stress and prevents loss of dopamine transporter function.
Topics: Animals; Cell Line, Tumor; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Estradiol; Fluoresceins; Gene Products, tat; HIV Envelope Protein gp120; Humans; Male; Molsidomine; Neuroblastoma; Oxidative Stress; Rats; Rats, Sprague-Dawley; Synaptosomes; tat Gene Products, Human Immunodeficiency Virus; Time Factors; Tritium | 2006 |
Peroxynitrite generated at the level produced by spinal cord injury induces peroxidation of membrane phospholipids in normal rat cord: reduction by a metalloporphyrin.
Topics: Aldehydes; Animals; Cell Membrane; Free Radical Scavengers; Lipid Peroxidation; Male; Malondialdehyde; Metalloporphyrins; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Phospholipids; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries | 2005 |
Inhibition of mitochondrial aldehyde dehydrogenase by nitric oxide-mediated S-nitrosylation.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Antibodies; Cysteine; Mitochondria; Mitochondrial Proteins; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrites; Rats; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Tumor Cells, Cultured | 2005 |
Ethanol metabolism alters interferon gamma signaling in recombinant HepG2 cells.
Topics: Blotting, Western; Cell Line; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Ethanol; Humans; Interferon-gamma; Intracellular Signaling Peptides and Proteins; Molsidomine; Nitric Oxide Donors; Oxidation-Reduction; Peroxynitrous Acid; Phosphorylation; Repressor Proteins; Signal Transduction; STAT1 Transcription Factor; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling Proteins | 2005 |
Nitric oxide stimulates the erythrocyte for ascorbate recycling.
Topics: Adult; Ascorbic Acid; Erythrocytes; Humans; Hydrogen-Ion Concentration; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; S-Nitrosothiols; Spermine; Superoxides; Temperature | 2006 |
Initiation of a superoxide-dependent chain oxidation of lactate dehydrogenase-bound NADH by oxidants of low and high reactivity.
Topics: Animals; Hydrogen Peroxide; Kinetics; L-Lactate Dehydrogenase; Molsidomine; NAD; NADP; Oxidants; Oxidation-Reduction; Oxygen; Peroxynitrous Acid; Spectrometry, Fluorescence; Superoxide Dismutase; Superoxides; Swine | 2005 |
Exogenous N-linoleoyl tyrosine marker as a tool for the characterization of cellular oxidative stress in macrophages.
Topics: Animals; Cell-Free System; Cells, Cultured; Copper; Hypochlorous Acid; Linoleic Acid; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Molsidomine; Oxidative Stress; Tyrosine | 2006 |
Effects of peroxynitrite and superoxide radicals on endothelial monolayer permeability: potential role of peroxynitrite in preeclampsia.
Topics: Cell Membrane Permeability; Cells, Cultured; Electric Impedance; Endothelium, Vascular; Female; Focal Adhesion Protein-Tyrosine Kinases; Horseradish Peroxidase; Humans; Intercellular Junctions; Molsidomine; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; Pre-Eclampsia; Pregnancy; Superoxide Dismutase; Umbilical Cord | 2005 |
Anti-inflammatory properties of micropatterned titanium coatings.
Topics: Animals; Anti-Inflammatory Agents; Biosensing Techniques; Cell Line; Coated Materials, Biocompatible; Macrophages; Mice; Molsidomine; Nitric Oxide Donors; Reactive Oxygen Species; Surface Properties; Titanium | 2006 |
Exogenous nitric oxide centrally enhances pulmonary reactivity in the normal and hypertensive rat.
Topics: Animals; Blood Pressure; Cardiac Output; Central Nervous System; Heart Rate; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Injections, Intraventricular; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Time Factors; Vascular Resistance; Vasoconstriction | 2005 |
Does central nitric oxide elicit pulmonary hypertension in conscious rats?
Topics: Adrenergic beta-Agonists; Analysis of Variance; Animals; Blood Pressure; Enzyme Inhibitors; Heart Rate; Hypertension; Hypoxia; Infusion Pumps, Implantable; Injections, Intraventricular; Isoproterenol; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Telemetry; Time Factors; Wakefulness | 2006 |
S-phase arrest by reactive nitrogen species is bypassed by okadaic acid, an inhibitor of protein phosphatases PP1/PP2A.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; cdc25 Phosphatases; Cell Cycle; Cell Cycle Proteins; Cell Line; Cells, Cultured; Cisplatin; Cyclin D1; DNA; DNA Damage; DNA-Binding Proteins; Dose-Response Relationship, Drug; In Vitro Techniques; Mice; Molsidomine; Nitrogen Dioxide; Nuclear Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Reactive Nitrogen Species; Replication Protein C; Retinoblastoma Protein; S Phase; Time Factors; Tumor Suppressor Proteins | 2006 |
Reactions of *NO2 with chromium(III) complexes with histamine and pyridoxamine ligands studied by the stopped-flow technique.
Topics: Chromium; Chromium Compounds; Free Radicals; Histamine; Hydrogen-Ion Concentration; Kinetics; Molsidomine; Nitrogen Dioxide; Pyridoxamine; Spectrophotometry; Temperature; Thermodynamics | 2006 |
The Brucella abortus xthA-1 gene product participates in base excision repair and resistance to oxidative killing but is not required for wild-type virulence in the mouse model.
Topics: Animals; Bacterial Proteins; Brucella abortus; Brucellosis; DNA Damage; DNA Repair; DNA, Bacterial; Enzyme Inhibitors; Exodeoxyribonucleases; Female; Hydrogen Peroxide; Methyl Methanesulfonate; Mice; Mice, Inbred BALB C; Molsidomine; Mutagens; Oxidants; Virulence | 2006 |
Heme catalyzes tyrosine 385 nitration and inactivation of prostaglandin H2 synthase-1 by peroxynitrite.
Topics: Amino Acid Sequence; Animals; Apoenzymes; Binding Sites; Catalysis; Chromatography, Ion Exchange; Cyclooxygenase 1; Electrophoresis, Polyacrylamide Gel; Free Radical Scavengers; Heme; Hemin; Holoenzymes; Hydroxyl Radical; Male; Models, Chemical; Molecular Sequence Data; Molsidomine; Peroxynitrous Acid; Seminal Vesicles; Sheep; Tyrosine | 2006 |
Therapeutic action of cannabinoid on axonal injury induced by peroxynitrite.
Topics: Adrenalectomy; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Axons; Brain Diseases; Cannabinoids; Corpus Callosum; Corticosterone; Disease Models, Animal; Dronabinol; Drug Therapy, Combination; Enzyme Inhibitors; Immunohistochemistry; Male; Molsidomine; Morpholines; Peroxynitrous Acid; Pyrazoles; Rats; Rats, Wistar | 2006 |
Peroxynitrite induces F-actin depolymerization and blockade of myosin ATPase stimulation.
Topics: Actins; Animals; Calorimetry, Differential Scanning; Enzyme Activation; Molsidomine; Myosins; Oxidation-Reduction; Peroxynitrous Acid; Protein Denaturation; Protein Folding; Rabbits; Temperature; Tyrosine | 2006 |
Effects of peroxynitrite and lipopolysaccharide on mitotic activity of C6 glioma cells.
Topics: Animals; Apoptosis; Cell Line, Tumor; Escherichia coli; Glioma; Lipopolysaccharides; Luminescent Measurements; Mitogens; Mitosis; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Rats | 2006 |
Co-administration of glutathione and nitric oxide enhances insulin sensitivity in Wistar rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Therapy, Combination; Fasting; Glutathione; Insulin Resistance; Liver; Male; Molsidomine; Nitric Oxide; Rats; Rats, Wistar | 2006 |
Green tea polyphenol epigallocatechin-3-gallate protects cells against peroxynitrite-induced cytotoxicity: modulatory effect of cellular G6PD status.
Topics: Apoptosis; Camellia sinensis; Catechin; Cell Line; Cell Survival; Fibroblasts; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Glutathione; Humans; Molsidomine; Oxidation-Reduction; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Tumor Suppressor Protein p53 | 2006 |
Inhibition of neuronal nitric oxide synthase in the rat hippocampus induces antidepressant-like effects.
Topics: Animals; Antidepressive Agents; Arginine; Dose-Response Relationship, Drug; Hippocampus; Imipramine; Indazoles; Male; Molsidomine; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Rats; Rats, Wistar | 2006 |
Inhibition of skeletal muscle S1-myosin ATPase by peroxynitrite.
Topics: Actins; Adenosine Diphosphate; Adenosine Triphosphatases; Animals; Catalysis; Cysteine; Dose-Response Relationship, Drug; Enzyme Stability; Magnesium; Molsidomine; Myosin Subfragments; Oxidation-Reduction; Peroxynitrous Acid; Protein Folding; Rabbits; Skeletal Muscle Myosins; Temperature; Time Factors; Tyrosine | 2006 |
Peroxynitrite generation and tyrosine nitration in defense responses in tobacco BY-2 cells.
Topics: Algal Proteins; Aniline Compounds; Antibodies, Anti-Idiotypic; Cells, Cultured; Cyclic GMP; Fluoresceins; Fungal Proteins; Molsidomine; Nicotiana; Nitric Oxide; Peroxynitrous Acid; Phytophthora; Proteins; Reactive Oxygen Species; Superoxides; Tyrosine; Uric Acid | 2006 |
Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage.
Topics: alpha-Synuclein; Benzothiazoles; Cell Differentiation; Cell Line, Tumor; Cytoplasm; Ferrous Compounds; Humans; Immunohistochemistry; Molsidomine; Mutation; Neuroblastoma; Oxidative Stress; Parkinson Disease; Proteasome Inhibitors; Reactive Oxygen Species; Rotenone; Thiazoles; Ubiquitin | 2006 |
Antioxidant effects of quinoline alkaloids and 2,4-di-tert-butylphenol isolated from Scolopendra subspinipes.
Topics: Alkaloids; Amidines; Animals; Antioxidants; Apolipoprotein B-100; Apolipoproteins B; Arthropods; Biphenyl Compounds; Chelating Agents; Copper; Electrophoretic Mobility Shift Assay; Free Radical Scavengers; Lipoproteins, LDL; Molsidomine; Oxidation-Reduction; Oxyquinoline; Picrates; Quinolines; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Thiobarbituric Acid Reactive Substances | 2006 |
Protection of peroxynitrite-induced DNA damage by dietary antioxidants.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Catechin; Deoxyguanosine; Diet; DNA; DNA Damage; Free Radical Scavengers; Humans; Molsidomine; Peroxynitrous Acid; Resveratrol; Stilbenes; Triterpenes; U937 Cells; Ursolic Acid | 2006 |
Carbon monoxide protects PC12 cells from peroxynitrite-induced apoptotic death by preventing the depolarization of mitochondrial transmembrane potential.
Topics: Animals; Apoptosis; Carbon Monoxide; Cells, Cultured; Heme Oxygenase-1; Intracellular Membranes; Membrane Potentials; Mitochondrial Membranes; Models, Biological; Molsidomine; PC12 Cells; Peroxynitrous Acid; Rats; Tin Compounds | 2006 |
Does central nitric oxide chronically modulate the acute hypoxic ventilatory response in conscious rats?
Topics: Acute Disease; Animals; Central Nervous System; Cerebral Ventricles; Hypoxia; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Plethysmography; Pulmonary Ventilation; Rats; Rats, Sprague-Dawley; Respiratory Mechanics | 2006 |
Effect of lycopene and beta-carotene on peroxynitrite-mediated cellular modifications.
Topics: Animals; Antioxidants; beta Carotene; Carotenoids; Cell Line; Cell Survival; Comet Assay; Cricetinae; Cricetulus; DNA Damage; Lycopene; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Tyrosine | 2006 |
Direct comparison of relaxation and cGMP production in human coronary by-pass grafts in response to stimulation with natriuretic peptides and a nitric oxide donor.
Topics: Adult; Aged; Aged, 80 and over; Atrial Natriuretic Factor; Coronary Artery Bypass; Cyclic GMP; Dose-Response Relationship, Drug; Female; Humans; Internal Mammary-Coronary Artery Anastomosis; Male; Mammary Arteries; Middle Aged; Molsidomine; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Natriuretic Peptides; Nitric Oxide Donors; Saphenous Vein; Tissue Culture Techniques; Vasodilation; Vasodilator Agents | 2006 |
Reactive nitrogen species induce nuclear factor-kappaB-mediated protein degradation in skeletal muscle cells.
Topics: Animals; Antioxidants; Cells, Cultured; Metalloendopeptidases; Molsidomine; Muscle Cells; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Myosin Heavy Chains; NF-kappa B; Nitric Oxide Donors; Penicillamine; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Rats; Reactive Nitrogen Species; Tyrosine; Ubiquitin | 2006 |
Bimodal effect of nitric oxide in the enzymatic activity of indoleamine 2,3-dioxygenase in human monocytic cells.
Topics: Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Molsidomine; Monocytes; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Sulfonamides; Triazenes; U937 Cells | 2006 |
Modulation of peroxynitrite-induced fibroblast injury by hesperetin: a role for intracellular scavenging and modulation of ERK signalling.
Topics: Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Hesperidin; Humans; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Signal Transduction; Tyrosine | 2006 |
Dynorphin-mediated antinociceptive effects of L-arginine and SIN-1 (an NO donor) in mice.
Topics: Analgesics; Animals; Arginine; Brain; Dynorphins; Enzyme Inhibitors; Injections, Intraventricular; Male; Mice; Molsidomine; Naloxone; Narcotic Antagonists; Nitric Oxide Donors; Pain Measurement | 2006 |
Nitric oxide-dependent vasodilatation by ethanolic extract of Hancornia speciosa via phosphatidyl-inositol 3-kinase.
Topics: Animals; Aorta, Thoracic; Apocynaceae; Brazil; Dose-Response Relationship, Drug; Ethanol; In Vitro Techniques; Male; Medicine, Traditional; Molsidomine; Nitric Oxide; Phenylephrine; Phosphatidylinositol 3-Kinases; Plant Bark; Plant Extracts; Rats; Rats, Wistar; Solvents; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2007 |
Impaired cerebrovascular reactivity after cortical spreading depression in rats: Restoration by nitric oxide or cGMP.
Topics: Analysis of Variance; Animals; Cerebral Cortex; Cerebrovascular Circulation; Cerebrovascular Disorders; Cortical Spreading Depression; Cyclic GMP; Drug Interactions; Hypercapnia; Laser-Doppler Flowmetry; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Rats; Rats, Wistar; Spermine; Thionucleotides; Time Factors | 2006 |
Thioredoxin reduces post-ischemic myocardial apoptosis by reducing oxidative/nitrative stress.
Topics: Animals; Apoptosis; Male; Mice; Molsidomine; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Superoxides; Thioredoxins; Tyrosine | 2006 |
Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Cell Survival; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Hydrogen Peroxide; Male; Middle Cerebral Artery; Molsidomine; NAD; Neuroprotective Agents; PC12 Cells; Poly(ADP-ribose) Polymerase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2006 |
Nitric oxide and peroxynitrite have different antiviral effects against hantavirus replication and free mature virions.
Topics: Animals; Antiviral Agents; Blotting, Western; Brain; Cells, Cultured; Chlorocebus aethiops; Hantavirus Infections; Humans; In Vitro Techniques; Mice; Mice, Inbred C57BL; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Orthohantavirus; Peroxynitrous Acid; Reverse Transcriptase Polymerase Chain Reaction; S-Nitroso-N-Acetylpenicillamine; Vero Cells; Virion; Virus Replication | 2006 |
Peroxynitrite induces HO-1 expression via PI3K/Akt-dependent activation of NF-E2-related factor 2 in PC12 cells.
Topics: Animals; Enzyme Activation; Gene Expression Regulation; Heme Oxygenase-1; Membrane Potentials; Molsidomine; NF-E2-Related Factor 2; Nuclear Proteins; PC12 Cells; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats | 2006 |
Nitrative inactivation of thioredoxin-1 and its role in postischemic myocardial apoptosis.
Topics: Amino Acid Substitution; Animals; Apoptosis; Cardiotonic Agents; Cyclic N-Oxides; Free Radical Scavengers; Humans; Imidazoles; Male; MAP Kinase Kinase Kinase 5; MAP Kinase Signaling System; Metalloporphyrins; Mice; Molsidomine; Mutagenesis, Site-Directed; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; NADP; Oxidation-Reduction; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Thioredoxins | 2006 |
Parkinson's disease genetic mutations increase cell susceptibility to stress: mutant alpha-synuclein enhances H2O2- and Sin-1-induced cell death.
Topics: alpha-Synuclein; Animals; Cell Death; Dose-Response Relationship, Drug; Genetic Predisposition to Disease; Hydrogen Peroxide; Molsidomine; Mutation; Parkinson Disease; PC12 Cells; Rats; Reactive Oxygen Species | 2007 |
Generation and release of nitrotyrosine O-sulfate by HepG2 human hepatoma cells upon SIN-1 stimulation: identification of SULT1A3 as the enzyme responsible.
Topics: Arylsulfotransferase; Carcinoma, Hepatocellular; Cell Line, Tumor; Dopamine; Humans; Kinetics; Molsidomine; Sulfotransferases; Tyrosine | 2007 |
Metallothioneins 1 and 2 attenuate peroxynitrite-induced oxidative stress in Parkinson disease.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Coenzymes; Dopamine; Enzyme Activation; Lipid Peroxidation; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molsidomine; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Ubiquinone | 2006 |
Effects of nitric oxide-active drugs on the discharge of subthalamic neurons: microiontophoretic evidence in the rat.
Topics: Action Potentials; Analysis of Variance; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Iontophoresis; Male; Molsidomine; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Wistar; S-Nitrosoglutathione; Subthalamic Nucleus; Thionucleotides; Time Factors | 2006 |
The role of reactive nitrogen species and cigarette smoke in activation of transcription factor NF-kappaB and implication to inflammatory processes.
Topics: Animals; Cell Line; Cells, Cultured; Humans; Inflammation; Lymphocytes; Molsidomine; NF-kappa B; Nicotiana; Nitric Oxide Donors; Penicillamine; Peroxynitrous Acid; Rats; Smoke | 2006 |
Inhibition of caspase-mediated apoptosis by peroxynitrite in traumatic brain injury.
Topics: Animals; Apoptosis; Blotting, Western; Brain Injuries; Caspases; Cells, Cultured; Cerebral Cortex; Cytochromes c; Disease Models, Animal; Embryo, Mammalian; Enzyme Inhibitors; Immunohistochemistry; In Situ Nick-End Labeling; Male; Mice; Molsidomine; N-Methylaspartate; Neural Inhibition; Neurons; Nitric Oxide Donors; Peroxynitrous Acid; Physical Stimulation; Rats; Rats, Sprague-Dawley; Staurosporine | 2006 |
Lens thiol depletion by peroxynitrite. Protective effect of pyruvate.
Topics: Animals; Decarboxylation; Glutathione; Lens, Crystalline; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Pyruvates; Rats; Sulfhydryl Compounds | 2007 |
Effects of oxidizing and reducing agents on ovine pulmonary artery responses to nitric oxide donors, sodium nitroprusside and 3-morpholino-sydnonimine.
Topics: Animals; Molsidomine; Nitric Oxide Donors; Nitroprusside; Oxidants; Pulmonary Artery; Reducing Agents; Sheep; Vasodilation | 2006 |
Modulation of voltage-gated Ca2+ current in vestibular hair cells by nitric oxide.
Topics: Animals; Calcium Channels, L-Type; Carbazoles; Cell Separation; Cyclic GMP; Data Interpretation, Statistical; Enzyme Inhibitors; Ethylmaleimide; Free Radical Scavengers; Hair Cells, Vestibular; In Vitro Techniques; Indoles; Molsidomine; Nitric Oxide; Nitroprusside; Patch-Clamp Techniques; Rats; Rats, Long-Evans; Signal Transduction | 2007 |
Nitric oxide differentially regulates the gene expression of caspase genes but not some autophagic genes.
Topics: Animals; Animals, Newborn; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 12; Autophagy-Related Protein 5; Beclin-1; Caspases; Cells, Cultured; Gene Expression Profiling; Gene Expression Regulation; Humans; Membrane Proteins; Mice; Microtubule-Associated Proteins; Molsidomine; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Oligonucleotide Array Sequence Analysis; Proteins | 2007 |
Inducible nitric oxide synthase (iNOS) activity could be responsible for resistance or sensitivity to IFN-gamma-induced apoptosis in several human hepatoma cell lines.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Coculture Techniques; Drug Resistance; Enzyme Inhibitors; Humans; Interferon-gamma; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase Type II; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Transcriptional Activation | 2006 |
Glycyrrhizin protection against 3-morpholinosydnonime-induced mitochondrial dysfunction and cell death in lung epithelial cells.
Topics: Apoptosis; Cytoprotection; Epithelial Cells; Glycyrrhizic Acid; Humans; Lung; Mitochondria; Mitochondrial Membranes; Molsidomine; Nitric Oxide Donors; Oxidative Stress; Permeability | 2007 |
Peroxynitrite mild nitration of albumin and LDL-albumin complex naturally present in plasma and tyrosine nitration rate-albumin impairs LDL nitration.
Topics: Antioxidants; Atherosclerosis; Humans; Lipoproteins, LDL; Molsidomine; Nitric Oxide Donors; Nitrogen Dioxide; Oxidation-Reduction; Peroxynitrous Acid; Serum Albumin; Tyrosine | 2007 |
SNAP and SIN-1 increase brain production of kynurenic acid.
Topics: Animals; Ascorbic Acid; Cerebral Cortex; Dose-Response Relationship, Drug; Free Radical Scavengers; In Vitro Techniques; Kynurenic Acid; Male; Molsidomine; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine | 2007 |
Inhibition of peroxynitrite precursors, NO and O2, at the onset of reperfusion improves myocardial recovery.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Free Radical Scavengers; Male; Molsidomine; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxygen Consumption; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Recovery of Function; Sodium-Potassium-Exchanging ATPase; Superoxide Dismutase; Treatment Outcome; Ventricular Function, Left | 2007 |
Peroxynitrite-mediated oxidative damage to brain mitochondria: Protective effects of peroxynitrite scavengers.
Topics: Aldehydes; Animals; Cell Respiration; Cerebral Cortex; Cyclic N-Oxides; Dose-Response Relationship, Drug; Electron Transport Complex I; Free Radical Scavengers; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Mitochondria; Molsidomine; Nitric Oxide Donors; Oxidative Stress; Oxygen Consumption; Penicillamine; Peroxynitrous Acid; Protein Carbonylation; Spin Labels; Tyrosine | 2007 |
Central nitric oxide blocks vasopressin, oxytocin and atrial natriuretic peptide release and antidiuretic and natriuretic responses induced by central angiotensin II in conscious rats.
Topics: Angiotensin II; Animals; Atrial Natriuretic Factor; Consciousness; Enzyme Inhibitors; Injections, Intraventricular; Male; Molsidomine; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Osmolar Concentration; Oxytocin; Peptide Hormones; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Sodium; Urine; Vasoconstrictor Agents; Vasopressins | 2007 |
Independency of myocardial stunning of endothelial stunning?
Topics: Animals; Blood Pressure; Coronary Circulation; Endothelium, Vascular; In Vitro Techniques; Male; Molsidomine; Muscle, Smooth, Vascular; Myocardial Reperfusion Injury; Myocardial Stunning; Rabbits; Research Design; Substance P; Time Factors; Vasodilation; Vasodilator Agents; Ventricular Function | 2007 |
The NO donor SIN-1 improves intestinal-arterial P(CO(2)) gap in experimental endotoxemia: an animal study.
Topics: Animals; Arteries; Blood Pressure; Carbon Dioxide; Disease Models, Animal; Endotoxemia; Intestines; Male; Microcirculation; Molsidomine; Nitric Oxide Donors; Oxygen; Partial Pressure; Regional Blood Flow; Swine; Vasodilator Agents | 2007 |
Nitric oxide modulates ionic transport in the isolated intestine of the eel, Anguilla anguilla.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Anguilla; Animals; Arginine; Bicarbonates; Chlorides; Cyclic GMP; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Intestinal Absorption; Intestinal Mucosa; Intestines; Membrane Potentials; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Permeability; Quinoxalines; Time Factors | 2007 |
Properties of spontaneous Ca2+ transients recorded from interstitial cells of Cajal-like cells of the rabbit urethra in situ.
Topics: Adrenergic alpha-Agonists; Animals; Boron Compounds; Caffeine; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium Signaling; Calcium-Transporting ATPases; Enzyme Inhibitors; Indoles; Inositol 1,4,5-Trisphosphate Receptors; Male; Membrane Potentials; Molsidomine; Muscle Contraction; Myocytes, Smooth Muscle; Nicardipine; Nitric Oxide; Nitric Oxide Donors; Phenylephrine; Rabbits; Receptors, Adrenergic, alpha; Ryanodine; Ryanodine Receptor Calcium Release Channel; Time Factors; Urethra | 2007 |
Signal transduction pathways affected by nitric oxide donors during neutrophil functional response in vitro.
Topics: Animals; CD11b Antigen; CD18 Antigens; Cell Adhesion; Cyclic GMP; Guanylate Cyclase; Humans; Hydrazines; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Nitric Oxide; Nitric Oxide Donors; Respiratory Burst; Signal Transduction | 2007 |
Cyclic AMP dependent down regulation in the relaxation of smooth muscle cells of cat esophagitis.
Topics: Adenylyl Cyclases; Animals; Blotting, Western; Bucladesine; Cats; Cell Membrane Permeability; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Down-Regulation; Esophagitis; In Vitro Techniques; Isoenzymes; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide Donors; Nitroprusside; Signal Transduction; Vasoactive Intestinal Peptide | 2007 |
The neuroprotective effect of Activin A and B: implication for neurodegenerative diseases.
Topics: Activins; Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Cell Line, Tumor; Cell Survival; Culture Media, Serum-Free; Histones; Humans; Molsidomine; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Oxidative Stress; Oxidopamine; PC12 Cells; Poly(ADP-ribose) Polymerases; Rats; Transfection; Tyrosine 3-Monooxygenase | 2007 |
Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling.
Topics: Animals; Carbon Monoxide; Catalytic Domain; Cell Survival; Glutamate-Cysteine Ligase; Heme Oxygenase (Decyclizing); Molsidomine; NF-E2-Related Factor 2; Nitric Oxide Donors; PC12 Cells; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Protoporphyrins; Rats; RNA, Small Interfering; Signal Transduction; Stress, Physiological | 2007 |
Nitration of a critical tyrosine residue in the allosteric inhibitor site of muscle glycogen phosphorylase impairs its catalytic activity.
Topics: Allosteric Regulation; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Glycogen Phosphorylase, Muscle Form; Mice; Models, Molecular; Molsidomine; Muscle Fibers, Skeletal; Muscle, Skeletal; Nitric Oxide Donors; Peroxynitrous Acid; Protein Structure, Tertiary; Tyrosine | 2007 |
Nitric oxide regulates growth cone filopodial dynamics via ryanodine receptor-mediated calcium release.
Topics: Animals; Calcium; Calcium Signaling; Cell Membrane; Cells, Cultured; Cyclic ADP-Ribose; Ganglia, Invertebrate; Gastropoda; Growth Cones; Guanylate Cyclase; Hydrazines; Image Processing, Computer-Assisted; Molsidomine; Neurons; Nitric Oxide; Nitric Oxide Donors; Pseudopodia; Ryanodine; Ryanodine Receptor Calcium Release Channel | 2007 |
Nitric oxide involvement in histamine-mediated PANC-1 cells growth.
Topics: Cell Line, Tumor; Enzyme Inhibitors; Histamine; Humans; Isoenzymes; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Reverse Transcriptase Polymerase Chain Reaction | 2007 |
Nitric oxide-donating aspirin (NCX 4016) inhibits neointimal thickening in a pig model of saphenous vein-carotid artery interposition grafting: a comparison with aspirin and morpholinosydnonimine (SIN-1).
Topics: Administration, Oral; Analysis of Variance; Anastomosis, Surgical; Animals; Aspirin; Carotid Arteries; Dose-Response Relationship, Drug; Graft Occlusion, Vascular; Male; Molsidomine; Nitric Oxide Donors; Saphenous Vein; Statistics, Nonparametric; Swine; Tunica Intima | 2007 |
Interferon-beta is neuroprotective against the toxicity induced by activated microglia.
Topics: Animals; Cells, Cultured; Coculture Techniques; Cytokines; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Interferon Type I; Interleukin-1beta; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Microglia; Molsidomine; N-Methylaspartate; Neurons; Neuroprotective Agents; Nitric Oxide; Peroxynitrous Acid; Pregnancy; Recombinant Proteins; Superoxides; Tumor Necrosis Factor-alpha | 2007 |
Role of nitric oxide/cyclic GMP pathway in regulating spontaneous excitations in detrusor smooth muscle of the guinea-pig bladder.
Topics: Action Potentials; Animals; Calcium; Cyclic GMP; Electrophysiology; Female; Guinea Pigs; In Vitro Techniques; Indoles; Isometric Contraction; Male; Molsidomine; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Phosphodiesterase Inhibitors; Piperazines; Purines; Signal Transduction; Sildenafil Citrate; Sulfones; Urinary Bladder | 2008 |
Chemical-biological fingerprinting: probing the properties of DNA lesions formed by peroxynitrite.
Topics: Chromatography, High Pressure Liquid; DNA Damage; Escherichia coli; Guanine; Molsidomine; Mutation; Peroxynitrous Acid; SOS Response, Genetics; Spectrometry, Mass, Electrospray Ionization | 2007 |
Reactive nitrogen and oxygen species in interleukin-1-mediated DNA damage associated with osteoarthritis.
Topics: Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; DNA Damage; Female; Interleukin-1alpha; Molsidomine; Nitric Oxide Donors; Nitroso Compounds; Osteoarthritis; Reactive Nitrogen Species; Reactive Oxygen Species; Sus scrofa | 2008 |
Structure-activity relationships of neoechinulin A analogues with cytoprotection against peroxynitrite-induced PC12 cell death.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Cell Death; Cell Survival; Cytoprotection; Indicators and Reagents; Indole Alkaloids; Luminol; Molsidomine; NADPH Dehydrogenase; Neurons; Neuroprotective Agents; Oxidation-Reduction; PC12 Cells; Peroxynitrous Acid; Piperazines; Rats; Reactive Nitrogen Species; Structure-Activity Relationship | 2007 |
Activity and subcellular trafficking of the sodium-coupled choline transporter CHT is regulated acutely by peroxynitrite.
Topics: Animals; Biotinylation; Cell Culture Techniques; Cell Line; Cell Line, Tumor; Cell Membrane; Choline; Cholinergic Agents; Culture Media; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Hemicholinium 3; Humans; Inhibitory Concentration 50; Kidney; Kinetics; L-Lactate Dehydrogenase; Luminescence; Membrane Potentials; Membrane Transport Proteins; Molsidomine; Neuroblastoma; Nitrogen; Oxidative Stress; Peroxynitrous Acid; Protein Transport; Rats; Sodium; Subcellular Fractions; Time Factors; Transfection; Tyrosine | 2008 |
Peroxynitrite donor impairs excitability of hippocampal CA1 neurons by inhibiting voltage-gated potassium currents.
Topics: Animals; Free Radical Scavengers; Hippocampus; In Vitro Techniques; Male; Metalloporphyrins; Molsidomine; Neurons; Nitric Oxide Donors; Peroxynitrous Acid; Potassium Channels, Voltage-Gated; Rats; Rats, Wistar | 2007 |
Targeting of phospholamban by peroxynitrite decreases beta-adrenergic stimulation in cardiomyocytes.
Topics: Animals; Calcium-Binding Proteins; Isoproterenol; Mice; Molsidomine; Myocardial Contraction; Myocytes, Cardiac; Peroxynitrous Acid; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Receptors, Adrenergic, beta; Serine | 2008 |
Effects of the nitric oxide donor SIN-1 on net hepatic glucose uptake in the conscious dog.
Topics: Animals; Blood Glucose; Blood Pressure; Carbon; Dogs; Fatty Acids, Nonesterified; Glucagon; Glucose; Glycerol; Heart Rate; Infusions, Intravenous; Insulin; Lactic Acid; Liver; Liver Circulation; Molsidomine; Nitric Oxide Donors; Portal Vein | 2008 |
Neuroglobin protects against nitric oxide toxicity.
Topics: Animals; Cell Death; Cell Line, Transformed; Dose-Response Relationship, Drug; Globins; Mice; Molsidomine; Nerve Tissue Proteins; Neuroglobin; Neurons; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Transfection | 2008 |
Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flavonols; Glutathione; MAP Kinase Signaling System; Molsidomine; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Nitric Oxide Donors; Nitro Compounds; Oxidative Stress; Peroxynitrous Acid; Phosphorylation; Proto-Oncogene Proteins c-myc; Rats; Rats, Sprague-Dawley; Signal Transduction | 2008 |
The role of nitric oxide and cGMP in somatostatin's protection against retinal ischemia.
Topics: Animals; Choline O-Acetyltransferase; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Fluorescent Antibody Technique, Indirect; In Situ Nick-End Labeling; Ischemia; Molsidomine; Nitric Oxide; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Retinal Diseases; Retinal Vessels; Somatostatin; Spermine | 2008 |
Hepatic portal venous delivery of a nitric oxide synthase inhibitor enhances net hepatic glucose uptake.
Topics: Animals; Blood Glucose; Carbon; Catheterization; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Nonesterified; Female; Glycerol; Hyperglycemia; Hyperinsulinism; Lactic Acid; Liver; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Portal Vein; Postprandial Period | 2008 |
Peroxynitrite participates in mechanisms involved in capacitation of cryopreserved cattle.
Topics: Acrosome Reaction; Animals; Cattle; Cryopreservation; Cyclic AMP-Dependent Protein Kinases; Female; Follicular Fluid; Genistein; Heparin; Indoles; Male; Maleimides; Molsidomine; Peroxynitrous Acid; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Semen Preservation; Sperm Capacitation; Spermatozoa | 2009 |
Lignans from the fruits of Forsythia suspensa.
Topics: Animals; Antioxidants; Chromatography, High Pressure Liquid; Forsythia; Fruit; Furans; Glucosides; Lignans; LLC-PK1 Cells; Magnetic Resonance Spectroscopy; Molecular Structure; Molsidomine; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; Plant Extracts; Swine | 2008 |
Cytoprotective effect of baicalein against peroxynitrite-induced toxicity in LLC-PK(1) cells.
Topics: Animals; Antioxidants; Cell Survival; Enzyme Inhibitors; Flavanones; Free Radical Scavengers; L-Lactate Dehydrogenase; LLC-PK1 Cells; Molsidomine; Peroxynitrous Acid; Swine | 2008 |
Modulation of hTREK-1 by carbon monoxide.
Topics: Carbon Monoxide; Cell Line; Cyclic GMP-Dependent Protein Kinases; Electrophysiology; Enzyme Inhibitors; Humans; Molsidomine; Nerve Tissue Proteins; Nitric Oxide; Organometallic Compounds; Patch-Clamp Techniques; Potassium Channels, Tandem Pore Domain; Recombinant Proteins | 2008 |
In vivo electrophysiology of dopamine-denervated striatum: focus on the nitric oxide/cGMP signaling pathway.
Topics: Action Potentials; Analysis of Variance; Animals; Corpus Striatum; Cyclic GMP; Denervation; Dopamine; Dose-Response Relationship, Radiation; Electric Stimulation; Enzyme Inhibitors; Male; Molsidomine; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidopamine; Rats; Rats, Wistar; Signal Transduction; Sympatholytics | 2008 |
Delay of phagosome maturation by a mycobacterial lipid is reversed by nitric oxide.
Topics: Adjuvants, Immunologic; Animals; Cells, Cultured; Cord Factors; Green Fluorescent Proteins; Humans; Hydrogen-Ion Concentration; Immunomagnetic Separation; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Molsidomine; Mycobacterium; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Phagocytosis; Phagosomes; Reactive Nitrogen Species | 2008 |
Participation of nitric oxide in the color change induced by UV radiation in the crab Chasmagnathus granulatus.
Topics: Animals; Brachyura; Brazil; Dose-Response Relationship, Drug; Male; Melanophores; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Pigmentation; Ultraviolet Rays | 2008 |
Biphasic effect of SIN-1 is reliant upon cardiomyocyte contractile state.
Topics: Animals; Calcium-Binding Proteins; Mice; Mice, Knockout; Molsidomine; Muscle Contraction; Myocytes, Cardiac | 2008 |
Nitric oxide induces gene expression of Jumonji and retinoblastoma 2 protein while reducing expression of atrial natriuretic peptide precursor type B in cardiomyocytes.
Topics: Animals; Cells, Cultured; Gene Expression Regulation; Heart; Mice; Molsidomine; Myocytes, Cardiac; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Donors; Oligonucleotide Array Sequence Analysis; Polycomb Repressive Complex 2; Retinoblastoma-Like Protein p130 | 2008 |
Degradation of extracellular matrix by peroxynitrite/peroxynitrous acid.
Topics: Animals; Bicarbonates; Cells, Cultured; Extracellular Matrix; Hydrogen-Ion Concentration; Molecular Structure; Molsidomine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Peroxynitrous Acid; Rats; Swine; Tyrosine | 2008 |
Nitric oxide modulates the frog heart ventricle morphodynamics.
Topics: Animals; Anura; Arginine; Cyclic GMP; Female; Heart Ventricles; In Vitro Techniques; Indazoles; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Perfusion; Serine; Software; Ventricular Function | 2008 |
Human neutrophil-pulmonary microvascular endothelial cell interactions in vitro: differential effects of nitric oxide vs. peroxynitrite.
Topics: 12E7 Antigen; Antibodies, Monoclonal; Antigens, CD; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cell Communication; Cell Movement; Cells, Cultured; Cytokines; Endothelial Cells; Humans; Imines; Metalloporphyrins; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Platelet Endothelial Cell Adhesion Molecule-1 | 2008 |
Oxidative and excitotoxic insults exert differential effects on spinal motoneurons and astrocytic glutamate transporters: Implications for the role of astrogliosis in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Astrocytes; Cell Survival; Cells, Cultured; Coculture Techniques; Cytoprotection; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glial Fibrillary Acidic Protein; Gliosis; Glutamic Acid; Homeostasis; Mice; Mice, Inbred C57BL; Molsidomine; Neurotoxins; Nitric Oxide Donors; Oxidative Stress; Time Factors | 2009 |
The peroxynitrite donor 3-morpholinosydnonimine induces reversible changes in electrophysiological properties of neurons of the guinea-pig spinal cord.
Topics: Action Potentials; Animals; Axons; Cell Membrane; Dose-Response Relationship, Drug; Extracellular Fluid; Female; Guinea Pigs; Molsidomine; Nerve Degeneration; Neural Conduction; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Peroxynitrous Acid; Sodium Channels; Spinal Cord; Spinal Cord Injuries; Tyrosine | 2008 |
Active compounds isolated from traditional Chinese prescription Wen-Pi-Tang protecting against peroxynitrite-induced LLC-PK(1) cell damage.
Topics: Animals; Apoptosis; Catechin; Cell Line; Drugs, Chinese Herbal; Epithelial Cells; Free Radicals; Kidney Tubules; Medicine, Chinese Traditional; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Swine | 2008 |
LDL protein nitration: implication for LDL protein unfolding.
Topics: Animals; Aorta; Apolipoprotein B-100; Cattle; Cells, Cultured; Cysteine; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Humans; Lipid Peroxidation; Lipid Peroxides; Lipoproteins, LDL; Models, Chemical; Molsidomine; Oxidation-Reduction; Peroxynitrous Acid; Protein Conformation; Protein Denaturation; Protein Processing, Post-Translational; Protein Structure, Secondary; Proteins; Reproducibility of Results; Tyrosine | 2008 |
Nitric oxide produces HLA-G nitration and induces metalloprotease-dependent shedding creating a tolerogenic milieu.
Topics: Cytotoxicity, Immunologic; Dose-Response Relationship, Immunologic; Histocompatibility Antigens Class I; HLA Antigens; HLA-G Antigens; Humans; Immune Tolerance; Killer Cells, Natural; Matrix Metalloproteinases; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Reverse Transcriptase Polymerase Chain Reaction; RNA Processing, Post-Transcriptional; Triazenes; Tumor Cells, Cultured | 2009 |
The metalloporphyrin FeTPPS but not by cyclosporin A antagonizes the interaction of peroxynitrate and hydrogen peroxide on cardiomyocyte cell death.
Topics: Animals; Cell Death; Cell Survival; Cells, Cultured; Chick Embryo; Cyclosporine; Drug Interactions; Free Radical Scavengers; Hydrogen Peroxide; Metalloporphyrins; Mitochondria; Molsidomine; Myocytes, Cardiac; Nitric Oxide; Peroxynitrous Acid; Reactive Oxygen Species; Superoxides | 2009 |
Changes in the proteome and infectivity of Leishmania infantum induced by in vitro exposure to a nitric oxide donor.
Topics: Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Gene Expression Regulation; Leishmania infantum; Macrophages; Mice; Molsidomine; Nitric Oxide Donors; Proteome; Protozoan Proteins | 2009 |
Peroxynitrite augments fibroblast-mediated tissue remodeling via myofibroblast differentiation.
Topics: Actins; Antibodies; Cell Differentiation; Cell Nucleus; Cells, Cultured; Collagen Type I; Desmin; Fetus; Fibroblasts; Fibronectins; Humans; Leupeptins; Lung; Molsidomine; Myoblasts; Neutralization Tests; NF-kappa B; Peroxynitrous Acid; Protein Transport; Transforming Growth Factor beta | 2008 |
Induction of adaptive response and enhancement of PC12 cell tolerance by lipopolysaccharide primarily through the upregulation of glutathione S-transferase A3 via Nrf2 activation.
Topics: Animals; Cell Survival; Cytoprotection; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Linoleic Acids; Lipid Peroxides; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Molsidomine; NF-E2-Related Factor 2; Oxidative Stress; PC12 Cells; Rats; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Transcription, Genetic; Up-Regulation | 2008 |
Nitric oxide (NO)-releasing aspirin and (NO) donors in protection of gastric mucosa against stress.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Immersion; Lipid Peroxidation; Male; Malondialdehyde; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Rats; Rats, Wistar; Reactive Oxygen Species; Regional Blood Flow; Restraint, Physical; S-Nitroso-N-Acetylpenicillamine; Stomach Ulcer; Stress, Psychological; Superoxide Dismutase | 2008 |
Nitric oxide and peroxynitrite regulate transporter transcription in rat liver slices.
Topics: Animals; Aspartate Aminotransferases; Carrier Proteins; Gadolinium; In Vitro Techniques; Interleukin-1beta; Liver; Male; Molsidomine; Nitrates; Nitric Oxide; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spermine; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2008 |
Hemin-H2O2-NO2(-) induced protein oxidation and tyrosine nitration are different from those of SIN-1: a study on glutamate dehydrogenase nitrative/oxidative modification.
Topics: Animals; Cattle; Circular Dichroism; Glutamate Dehydrogenase; Hemin; Hydrogen Peroxide; Mass Spectrometry; Molsidomine; Nitric Oxide Donors; Nitrites; Oxidation-Reduction; Reactive Nitrogen Species; Tyrosine | 2009 |
Physiopathological effects of the NO donor 3-morpholinosydnonimine on rat cortical synaptosomes.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Cerebral Cortex; Chromans; In Vitro Techniques; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Mitochondria; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Oxidation-Reduction; Oxygen Consumption; Peroxynitrous Acid; Phosphatidylserines; Rats; Reactive Oxygen Species; Synaptosomes; Water | 2009 |
Morphological and physiological study of the cardiac NOS/NO system in the Antarctic (Hb-/Mb-) icefish Chaenocephalus aceratus and in the red-blooded Trematomus bernacchii.
Topics: Animals; Antarctic Regions; Arginine; Blotting, Western; Cyclic GMP; Endocardium; Female; Fluorescent Antibody Technique; Heart Ventricles; Hemodynamics; Male; Molsidomine; Myocardium; NADPH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Perciformes; Signal Transduction; Stroke Volume | 2009 |
Cisplatin upregulates mitochondrial nitric oxide synthase and peroxynitrite formation to promote renal injury.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 3; Cisplatin; Coloring Agents; Cytochromes c; Cytoskeleton; Immunohistochemistry; Kidney Diseases; Male; Mitochondria; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Peroxynitrous Acid; Phalloidine; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2009 |
Synthesis and biological activities of neoechinulin A derivatives: new aspects of structure-activity relationships for neoechinulin A.
Topics: Animals; Antioxidants; Brain Chemistry; Cell Survival; Indicators and Reagents; Indole Alkaloids; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Molsidomine; Nitrates; PC12 Cells; Peroxynitrous Acid; Piperazines; Protective Agents; Rats; Structure-Activity Relationship; Tyrosine | 2008 |
Alpha-lipoic acid potently inhibits peroxynitrite-mediated DNA strand breakage and hydroxyl radical formation: implications for the neuroprotective effects of alpha-lipoic acid.
Topics: Animals; Antioxidants; DNA Breaks, Double-Stranded; Electron Spin Resonance Spectroscopy; Humans; Hydroxyl Radical; Molsidomine; Neuroprotective Agents; Nitric Oxide Donors; Oxidative Stress; Oxygen Consumption; Peroxynitrous Acid; Thioctic Acid | 2009 |
Antioxidant activity of bisabolol: inhibitory effects on chemiluminescence of human neutrophil bursts and cell-free systems.
Topics: Antioxidants; Candida albicans; Cell-Free System; Humans; Hydrogen Peroxide; Hypochlorous Acid; Luminescence; Luminol; Molsidomine; Monocyclic Sesquiterpenes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidative Stress; Reactive Oxygen Species; Respiratory Burst; Sesquiterpenes | 2009 |
Modification of surfactant protein D by reactive oxygen-nitrogen intermediates is accompanied by loss of aggregating activity, in vitro and in vivo.
Topics: Amino Acid Sequence; Animals; Bronchoalveolar Lavage Fluid; Humans; Mice; Molsidomine; Nitrogen Dioxide; Peroxynitrous Acid; Protein Structure, Quaternary; Protein Structure, Tertiary; Pulmonary Surfactant-Associated Protein D; Rats; Recombinant Proteins; Tandem Mass Spectrometry; Tyrosine | 2009 |
Cruciferous dithiolethione-mediated coordinated induction of total cellular and mitochondrial antioxidants and phase 2 enzymes in human primary cardiomyocytes: cytoprotection against oxidative/electrophilic stress and doxorubicin toxicity.
Topics: Aldehydes; Antineoplastic Agents; Antioxidants; Cell Line; Cytoprotection; Doxorubicin; Humans; Metabolic Detoxication, Phase II; Mitochondria; Molsidomine; Myocytes, Cardiac; Oxidative Stress; Reactive Oxygen Species; Thiones; Thiophenes; Up-Regulation; Xanthine Oxidase | 2009 |
SIN-1 cytotoxicity to PC12 cells is mediated by thiol-sensitive short-lived substances generated through SIN-1 decomposition in culture medium.
Topics: Animals; Caspase 3; Cell Death; Cells, Cultured; Enzyme Inhibitors; Molsidomine; Oxidative Stress; PC12 Cells; Peroxynitrous Acid; Rats; Sulfhydryl Compounds; Superoxide Dismutase | 2009 |
Effect of nitric oxide donors on NADPH oxidase signaling pathway in human neutrophils in vitro.
Topics: Diethylamines; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Nitric Oxide; Nitric Oxide Donors; Phosphorylation; Protein Kinase C; Signal Transduction; Substrate Specificity | 2009 |
Reactive nitrogen species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Cell Proliferation; Cells, Cultured; Collagen; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Extracellular Matrix; Female; Humans; Liver; Liver Cirrhosis; Matrix Metalloproteinase 1; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2009 |
Nitric oxide donor-mediated inhibition of phosphorylation shows that light-mediated degradation of photosystem II D1 protein and phosphorylation are not tightly linked.
Topics: Apoproteins; Araceae; Chloroplasts; Cysteine; Electrophoresis, Polyacrylamide Gel; Light; Molsidomine; Nitric Oxide Donors; Phosphorylation; Photosystem II Protein Complex; Plant Proteins; S-Nitrosothiols | 2009 |
Nitric oxide- and cGMP-active compounds affect the discharge of substantia nigra pars reticulata neurons: in vivo evidences in the rat.
Topics: Action Potentials; Animals; Cyclic GMP; Down-Regulation; Enzyme Inhibitors; Iontophoresis; Male; Molsidomine; Neural Inhibition; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Signal Transduction; Substantia Nigra; Up-Regulation | 2009 |
Cyclic guanosine monophosphate signaling cascade mediates pigment aggregation in freshwater shrimp chromatophores.
Topics: Aminoquinolines; Animals; Brazil; Chromatophores; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Fresh Water; Guanylate Cyclase; Molsidomine; Nitroprusside; Palaemonidae; Pigments, Biological; Protoporphyrins; Signal Transduction | 2009 |
Cytoprotective effect of lignans from Forsythia suspensa against peroxynitrite-induced LLC-PK1 cell damage.
Topics: Animals; Cytoprotection; Forsythia; Lignans; LLC-PK1 Cells; Molecular Structure; Molsidomine; Peroxynitrous Acid; Plant Extracts; Swine | 2009 |
PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major.
Topics: Animals; Biopterins; Drug Resistance; Folic Acid; Hydrogen Peroxide; Leishmania major; Methylnitronitrosoguanidine; Molsidomine; Multienzyme Complexes; Mutation; Nitric Oxide Donors; Nitroso Compounds; Oxidants; Oxidoreductases; Protozoan Proteins; Pteridines; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 2009 |
Peroxynitrite induces gene expression in intervertebral disc cells.
Topics: Active Transport, Cell Nucleus; Adolescent; Adult; Cell Nucleus; Cells, Cultured; Female; Gene Expression; Humans; Immunohistochemistry; Interleukin-10; Interleukin-1beta; Interleukin-6; Interleukin-8; Intervertebral Disc; Intervertebral Disc Displacement; Male; Middle Aged; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Tyrosine | 2009 |
Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo.
Topics: Animals; Anthocyanins; Apoptosis; Cells, Cultured; Chromatography, High Pressure Liquid; Lipid Peroxidation; Male; Mice; Molsidomine; N-Methylaspartate; Neuroprotective Agents; Prosencephalon; Retinal Ganglion Cells; Vaccinium myrtillus | 2009 |
NOC-9, a selective nitric oxide donor, induces flight reactions in the dorsolateral periaqueductal gray of rats by activating soluble guanylate cyclase.
Topics: Animals; Catheterization; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escape Reaction; Guanylate Cyclase; Male; Microinjections; Molsidomine; Motor Activity; Multivariate Analysis; Nitric Oxide Donors; Oxadiazoles; Periaqueductal Gray; Quinoxalines; Random Allocation; Rats; Rats, Wistar; Time Factors; Triazenes | 2009 |
Chemical model systems for cellular nitros(yl)ation reactions.
Topics: Animals; Cattle; Glutathione; In Vitro Techniques; Isocitrate Dehydrogenase; Models, Chemical; Molsidomine; Nitric Oxide; Nitrosation; Peroxynitrous Acid; Phenol; Superoxide Dismutase; Swine | 2009 |
Tempol protection of spinal cord mitochondria from peroxynitrite-induced oxidative damage.
Topics: Animals; Antioxidants; Cell Respiration; Cyclic N-Oxides; Female; Mitochondria; Molsidomine; Nitric Oxide Donors; Nitroso Compounds; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Spin Labels; Spinal Cord; Tyrosine | 2009 |
Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cell Line; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; GAP-43 Protein; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hydrogen Peroxide; Hydroxyquinolines; Hypoxia-Inducible Factor 1, alpha Subunit; Iron Chelating Agents; Mice; Mice, Transgenic; Molsidomine; Motor Neurons; Neurites; Neuroprotective Agents; Phosphopyruvate Hydratase; Piperazines; Proto-Oncogene Proteins c-akt; Receptors, Transferrin; Signal Transduction; Superoxide Dismutase; Superoxide Dismutase-1; Vascular Endothelial Growth Factor A | 2009 |
Spinal and peripheral mechanisms involved in the enhancement of morphine analgesia in acutely inflamed mice.
Topics: Acute Disease; Analgesia; Animals; Carrageenan; Glyburide; Inflammation; Injections, Spinal; Mice; Molsidomine; Morphine; Naloxone; Nociceptors; omega-N-Methylarginine; Pain; Quaternary Ammonium Compounds; Spinal Cord; Temperature | 2010 |
Spin trapping and cytoprotective properties of fluorinated amphiphilic carrier conjugates of cyclic versus linear nitrones.
Topics: Aldehydes; Animals; Antihypertensive Agents; Cattle; Cross-Linking Reagents; Drug Carriers; Endothelial Cells; Fluorine; Hydrogen Peroxide; Molsidomine; Nitrogen Oxides; Spin Trapping | 2009 |
Peroxynitrite mediates muscle insulin resistance in mice via nitration of IRbeta/IRS-1 and Akt.
Topics: Animals; Dietary Fats; Gene Expression Regulation, Enzymologic; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Molsidomine; Muscle, Skeletal; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Signal Transduction | 2009 |
Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia.
Topics: Arginase; Arginine; Biopterins; Endothelial Cells; Female; Humans; Molsidomine; NADPH Oxidases; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Pre-Eclampsia; Pregnancy | 2010 |
Inhibition of the soluble epoxide hydrolase by tyrosine nitration.
Topics: Animals; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Mice; Mice, Inbred C57BL; Mice, Obese; Molsidomine; Mutagenesis, Site-Directed; Oxidative Stress; Peroxynitrous Acid; Tyrosine | 2009 |
Ethyl pyruvate inhibits peroxynitrite-induced DNA damage and hydroxyl radical generation: implications for neuroprotection.
Topics: DNA Damage; Electron Spin Resonance Spectroscopy; Hydroxyl Radical; Molsidomine; Neuroprotective Agents; Peroxynitrous Acid; Pyruvates | 2010 |
Inhibition of peroxynitrite-mediated DNA strand cleavage and hydroxyl radical formation by aspirin at pharmacologically relevant concentrations: implications for cancer intervention.
Topics: Anticarcinogenic Agents; Aspirin; Bacteriophage phi X 174; DNA Cleavage; Humans; Hydroxyl Radical; Molsidomine; Neoplasms; Peroxynitrous Acid; Plasmids | 2009 |
Elevated plasma concentration of NO and cGMP may be responsible for the decreased platelet aggregation and platelet leukocyte conjugation in platelets hypo-responsive to catecholamines.
Topics: Adenosine Triphosphate; Adult; Asian People; Blood Platelets; Catecholamines; Cyclic AMP; Cyclic GMP; Female; Humans; Leukocyte Common Antigens; Leukocytes; Male; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Platelet Aggregation; Platelet Aggregation Inhibitors; Young Adult | 2009 |
IL-8 production by macrophages is synergistically enhanced when cigarette smoke is combined with TNF-alpha.
Topics: Antioxidants; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Antagonism; Drug Combinations; Drug Synergism; Emphysema; Glutathione; Humans; Interleukin-8; Macrophages; Molsidomine; NF-kappa B; Nitric Oxide Donors; Reactive Oxygen Species; Smoke; Time Factors; Tumor Necrosis Factor-alpha; Up-Regulation | 2010 |
The role of superoxide anion in the inhibitory effect of SIN-1 in thrombin-activated human platelet adhesion.
Topics: Blood Platelets; Blood Proteins; Cell Adhesion; Enzyme Inhibitors; Fibrinogen; Free Radical Scavengers; Guanylate Cyclase; Humans; Molsidomine; Nitrates; Peroxynitrous Acid; Solubility; Superoxides; Thrombin; Tyrosine | 2010 |
Determination of glutathione, mitochondrial transmembrane potential, and cytotoxicity in H9c2 cardiomyoblasts exposed to reactive oxygen and nitrogen species.
Topics: Animals; Antioxidants; Benzimidazoles; Carbocyanines; Cell Line; Cell Survival; Fluorescent Dyes; Glutathione; Hydrazines; Membrane Potential, Mitochondrial; Mice; Molsidomine; Myocytes, Cardiac; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; Reactive Nitrogen Species; Reactive Oxygen Species | 2010 |
Group IIA secretory phospholipase A2 (GIIA) mediates apoptotic death during NMDA receptor activation in rat primary cortical neurons.
Topics: Animals; Annexin A5; Apoptosis; Calcium; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Flow Cytometry; Glutamic Acid; Group II Phospholipases A2; Mitochondria; Molsidomine; Neurons; Nitric Oxide Donors; Nitroso Compounds; Pregnancy; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Xanthine; Xanthine Oxidase | 2010 |
cAMP-independent activation of protein kinase A by the peroxynitrite generator SIN-1 elicits positive inotropic effects in cardiomyocytes.
Topics: Animals; Calcium; Calcium-Binding Proteins; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Humans; Male; Mice; Mice, Inbred C57BL; Molsidomine; Muscle Cells; Myocytes, Cardiac; Okadaic Acid; Phosphorylation; Pyrroles | 2010 |
Metallocorroles as cytoprotective agents against oxidative and nitrative stress in cellular models of neurodegeneration.
Topics: Animals; Caspase 3; Cell Count; Cell Death; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Humans; Hydrogen Peroxide; In Situ Nick-End Labeling; Metalloporphyrins; Mice; Molsidomine; Motor Neurons; Neuroblastoma; Neuroprotective Agents; Nitrates; Oxidative Stress; Oxidopamine; Porphyrins; Sympatholytics | 2010 |
P38 MAP kinase in valve interstitial cells is activated by angiotensin II or nitric oxide/peroxynitrite, but reduced by Toll-like receptor-2 stimulation.
Topics: Angiotensin II; Animals; Aortic Valve; Enzyme Activation; Molsidomine; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Phosphorylation; Receptors, Angiotensin; Signal Transduction; Swine; Toll-Like Receptor 2 | 2009 |
eNOS plays a major role in adiponectin synthesis in adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Animals; Blotting, Western; DNA, Mitochondrial; Enzyme Inhibitors; Fluorescent Antibody Technique; Genotype; Guanosine; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron; Molecular Weight; Molsidomine; Nitric Oxide Donors; Nitric Oxide Synthase Type III; RNA, Small Interfering | 2010 |
Morin modulates the oxidative stress-induced NF-kappaB pathway through its anti-oxidant activity.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Binding Sites; Cell Line; Cyclooxygenase 2; DNA; Dose-Response Relationship, Drug; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Free Radical Scavengers; I-kappa B Kinase; Inflammation Mediators; Molsidomine; NF-kappa B; NF-kappa B p50 Subunit; Nitric Oxide Synthase Type II; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Signal Transduction; tert-Butylhydroperoxide; Transcription Factor RelA | 2010 |
Nitrosation-modulating effect of ascorbate in a model dynamic system of coexisting nitric oxide and superoxide.
Topics: Antioxidants; Ascorbic Acid; Computer Simulation; Kinetics; Models, Chemical; Molsidomine; Nitric Oxide; Nitrosation; Superoxides | 2010 |
Nitric oxide-induced IL-8 expression is mediated by NF-kappaB and AP-1 in gastric epithelial AGS cells.
Topics: Anti-Ulcer Agents; CCAAT-Enhancer-Binding Proteins; Cell Line; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Epithelial Cells; Gastric Mucosa; Gene Expression Regulation; Genes, Reporter; Humans; Interleukin-8; Molsidomine; NF-kappa B; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; RNA, Messenger; Time Factors; Transcription Factor AP-1 | 2009 |
Dorsal raphe nucleus regulation of a panic-like defensive behavior evoked by chemical stimulation of the rat dorsal periaqueductal gray matter.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Disease Models, Animal; Escape Reaction; Homocysteine; Kainic Acid; Male; Molsidomine; Panic Disorder; Periaqueductal Gray; Piperazines; Pyridines; Raphe Nuclei; Rats; Rats, Wistar; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists | 2010 |
Potent inhibition of peroxynitrite-induced DNA strand breakage and hydroxyl radical formation by dimethyl sulfoxide at very low concentrations.
Topics: Cytoprotection; Dimethyl Sulfoxide; DNA Breaks; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Hydroxyl Radical; Molsidomine; Oxygen Consumption; Peroxynitrous Acid; Plasmids; Time Factors | 2010 |
Protective effects of flavonoids against oxidative stress induced by simulated microgravity in SH-SY5Y cells.
Topics: Animals; Antioxidants; Cell Line, Tumor; Cell Survival; Flavonols; Humans; Hydrogen Peroxide; Luteolin; Molecular Structure; Molsidomine; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Oxidants; Oxidative Stress; Quercetin; Reactive Oxygen Species; Tyrosine; Weightlessness | 2010 |
Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite.
Topics: Animals; Cell Line; Cell Survival; Epithelial Cells; Free Radical Scavengers; Kidney Tubules, Collecting; Mice; Molsidomine; Peroxynitrous Acid; Reactive Nitrogen Species; Resveratrol; Serum Albumin, Bovine; Stilbenes | 2010 |
Inhibition of nitric oxide synthase during sepsis: revival because of isoform selectivity?
Topics: Acidosis; Animals; Blood Circulation; Clinical Trials, Phase II as Topic; Early Termination of Clinical Trials; Endotoxemia; Fluid Therapy; Humans; Imidazoles; Mice; Mice, Knockout; Molsidomine; Nitric Oxide Synthase Type II; Norepinephrine; omega-N-Methylarginine; Protein Isoforms; Pyridines; Sepsis; Shock, Septic; Swine | 2010 |
Investigation of relaxant effects of new agents affecting nitric oxide/cyclic guanosine monophosphate pathway on sheep oddi sphincter.
Topics: Animals; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Guanylate Cyclase; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Sheep; Sphincter of Oddi; Triazenes | 2010 |
Geniposide induces the expression of heme oxygenase-1 via PI3K/Nrf2-signaling to enhance the antioxidant capacity in primary hippocampal neurons.
Topics: Antioxidants; Apoptosis; Biological Transport; Cell Line; Cell Nucleus; Fruit; Gardenia; Heme Oxygenase-1; Hippocampus; Humans; Iridoids; Molsidomine; NF-E2-Related Factor 2; Oxidative Stress; Phosphatidylinositol 3-Kinases; Plant Extracts; Protoporphyrins; Signal Transduction; Up-Regulation | 2010 |
Apoptosis of hepatic stellate cells mediated by specific protein nitration.
Topics: Animals; Apoptosis; Caspase 3; Caspase 9; Cell Line; DNA Fragmentation; Hepatic Stellate Cells; Humans; Inflammation; Intracellular Signaling Peptides and Proteins; Liver Cirrhosis; Molsidomine; Nitric Oxide; Peroxynitrous Acid; Protein-Tyrosine Kinases; Rats; Signal Transduction; src-Family Kinases; Syk Kinase; Tyrosine | 2011 |
Similarity and dissimilarity of thiols as anti-nitrosative agents in the nitric oxide-superoxide system.
Topics: Molsidomine; Nitric Oxide; Nitrosation; Oxidative Stress; Sulfhydryl Compounds; Superoxides | 2011 |
[Effect of NO on automaticity of rabbit sino-atrial node].
Topics: Action Potentials; Animals; Heart Rate; Molsidomine; Nitric Oxide; Nitroprusside; Rabbits; Sinoatrial Node | 2002 |
3-morpholinosydnonimine participates in the attenuation of neointima formation via inhibition of annexin A2-mediated vascular smooth muscle cell migration.
Topics: Amino Acid Sequence; Animals; Annexin A2; Becaplermin; Cell Movement; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation; Male; Molecular Sequence Data; Molsidomine; Muscle, Smooth, Vascular; Neointima; Nitric Oxide Donors; Platelet-Derived Growth Factor; Proteome; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Vasodilator Agents | 2011 |
Differential effects of NADPH oxidase and xanthine oxidase inhibition on sympathetic reinnervation in postinfarct rat hearts.
Topics: Acetophenones; Allopurinol; Animals; Arrhythmias, Cardiac; Coronary Vessels; Ethidium; Male; Molsidomine; Myocardial Infarction; Myocardium; NADPH Oxidases; Nerve Growth Factor; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Superoxides; Sympathetic Nervous System; Tyrosine; Xanthine Oxidase | 2011 |
Detection of peroxynitrite accumulation in Arabidopsis thaliana during the hypersensitive defense response.
Topics: Aniline Compounds; Arabidopsis; Bacterial Proteins; Boron Compounds; Fluoresceins; Molsidomine; Nitric Oxide; Peroxynitrous Acid; Photometry; Plant Diseases; Plant Leaves; Protein Processing, Post-Translational; Pseudomonas syringae; Signal Transduction; Tyrosine; Uric Acid | 2011 |
Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Endothelial Cells; Enzyme Activation; Free Radical Scavengers; Hypertension, Pulmonary; Metalloporphyrins; Molsidomine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Polyethylene Glycols; Protein Processing, Post-Translational; Pulmonary Artery; Pulmonary Circulation; Second Messenger Systems; Sheep; Spermine; Superoxide Dismutase; Vasodilation; Vasodilator Agents | 2011 |
Early disruption of the actin cytoskeleton in cultured cerebellar granule neurons exposed to 3-morpholinosydnonimine-oxidative stress is linked to alterations of the cytosolic calcium concentration.
Topics: Actin Cytoskeleton; Animals; Calcium; Calcium Channel Agonists; Calcium Channels, L-Type; Cells, Cultured; Cerebellum; Molsidomine; Neurons; Nifedipine; Oxidative Stress; Peroxynitrous Acid; Pyrroles; Rats; Rats, Wistar | 2011 |
A novel epoxypropoxy flavonoid derivative and topoisomerase II inhibitor, MHY336, induces apoptosis in prostate cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Biocatalysis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type II; Down-Regulation; Flavonoids; Free Radical Scavengers; Humans; Male; Molsidomine; Oxidative Stress; Prostatic Neoplasms; Reactive Oxygen Species; Topoisomerase II Inhibitors; Tumor Suppressor Protein p53; Up-Regulation | 2011 |
5-HT1A autoreceptor modulation of locomotor activity induced by nitric oxide in the rat dorsal raphe nucleus.
Topics: Animals; Dose-Response Relationship, Drug; Glycine; Male; Molsidomine; Motor Activity; Nitric Oxide; Raphe Nuclei; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Antagonists | 2011 |
Cytotoxicity and genotoxicity studies of two free-radical generators (AAPH and SIN-1) in human microvascular endothelial cells (HMEC-1) and human peripheral lymphocytes.
Topics: Amidines; Apoptosis; Cell Cycle; Cell Line; Cells, Cultured; Cytotoxins; Endothelial Cells; Endothelium, Vascular; Humans; Lymphocytes; Microcirculation; Micronucleus Tests; Molsidomine; Mutagens | 2011 |
Effects of modulating in vivo nitric oxide production on the incidence and severity of PDE4 inhibitor-induced vascular injury in Sprague-Dawley rats.
Topics: Animals; Azepines; Biomarkers; Dose-Response Relationship, Drug; Enzyme Inhibitors; Immunohistochemistry; Male; Mesenteric Arteries; Molsidomine; NG-Nitroarginine Methyl Ester; Niacinamide; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Phosphodiesterase 4 Inhibitors; Rats; Rats, Sprague-Dawley; Tyrosine; Vascular System Injuries | 2011 |
In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways.
Topics: Animals; Blood Platelets; Cyclic GMP; Humans; Male; Molsidomine; Nitric Oxide Donors; Nitroprusside; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Conformation; Rats; Rats, Sprague-Dawley; Receptors, Fibrinogen; S-Nitrosoglutathione | 2011 |
Peroxynitrite treatment reduces adenosine uptake via the equilibrative nucleoside transporter in rat astrocytes.
Topics: Adenosine; Animals; Astrocytes; Blotting, Western; Immunohistochemistry; Molsidomine; Nitric Oxide Donors; Nucleoside Transport Proteins; Oxidants; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar | 2011 |
High glucose induced rat aorta vascular smooth muscle cell oxidative injury: involvement of protein tyrosine nitration.
Topics: Animals; Aorta; Cell Survival; Glucose; Glucose Oxidase; Glutathione; Hemin; Lipid Peroxidation; Male; Molsidomine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Primary Cell Culture; Rats; Rats, Wistar; Reactive Oxygen Species; Tyrosine | 2011 |
In dialyzed squid axons oxidative stress inhibits the Na+/Ca2+ exchanger by impairing the Cai2+-regulatory site.
Topics: Adenosine Triphosphate; Animals; Axons; Calcium; Chelating Agents; Decapodiformes; Dialysis; Egtazic Acid; Hydrogen Peroxide; Hydrogen-Ion Concentration; Loligo; Molsidomine; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; Phenanthrolines; Sodium-Calcium Exchanger | 2011 |
Intimal hyperplasia in balloon dilated coronary arteries is reduced by local delivery of the NO donor, SIN-1 via a cGMP-dependent pathway.
Topics: Actins; Analysis of Variance; Angioplasty, Balloon, Coronary; Animals; Coronary Angiography; Coronary Restenosis; Coronary Vessels; Cyclic GMP; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Guanylate Cyclase; Hyperplasia; Intermediate Filaments; Molsidomine; Myosins; NAD(P)H Dehydrogenase (Quinone); NADP; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Signal Transduction; Sus scrofa; Time Factors; Tunica Intima | 2011 |
Upregulation of neuronal nitric oxide synthase in the periphery promotes pain hypersensitivity after peripheral nerve injury.
Topics: Animals; Arginine; Hyperalgesia; Male; Molsidomine; Neuralgia; Nitric Oxide Synthase Type I; Pain Threshold; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Schwann Cells; Sensory Receptor Cells; Up-Regulation | 2011 |
Administration of a nitric oxide donor inhibits mglA expression by intracellular Francisella tularensis and counteracts phagosomal escape and subversion of TNF-α secretion.
Topics: Animals; Asialoglycoproteins; Bacterial Proteins; Blotting, Western; Cell Line; Cell Survival; Francisella tularensis; Lectins, C-Type; Macrophages; Membrane Proteins; Mice; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Real-Time Polymerase Chain Reaction; RNA; S-Nitroso-N-Acetylpenicillamine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tularemia; Tumor Necrosis Factor-alpha | 2011 |
Protein kinase C mediates peroxynitrite toxicity to oligodendrocytes.
Topics: Acetophenones; Animals; Benzopyrans; Carbazoles; Cells, Cultured; Chlorides; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Indoles; Isoenzymes; Maleimides; Molsidomine; Oligodendroglia; Peroxynitrous Acid; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Tetradecanoylphorbol Acetate; Zinc Compounds | 2011 |
S-nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Injuries; Brain-Derived Neurotrophic Factor; Glutathione; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Male; Molsidomine; Nerve Regeneration; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, trkB; S-Nitrosoglutathione; Synaptophysin; Thiobarbituric Acid Reactive Substances | 2011 |
Oxidative species increase arginase activity in endothelial cells through the RhoA/Rho kinase pathway.
Topics: Animals; Arginase; Carbazoles; Cattle; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Guanine Nucleotide Exchange Factors; Hydrogen Peroxide; Molsidomine; Nitric Oxide Donors; Nitric Oxide Synthase; Oxidants; Protein Kinase C; Rho Guanine Nucleotide Exchange Factors; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2012 |
Myricetin affords protection against peroxynitrite-mediated DNA damage and hydroxyl radical formation.
Topics: Animals; Astrocytes; Bacteriophage phi X 174; Cells, Cultured; DNA Damage; DNA, Viral; Electron Spin Resonance Spectroscopy; Flavonoids; Hydroxyl Radical; Molsidomine; Oxygen; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley | 2011 |
Threshold of peroxynitrite cytotoxicity in bovine pulmonary artery endothelial and smooth muscle cells.
Topics: Animals; Apoptosis; Caspase 3; Cattle; Endothelial Cells; Endothelium, Vascular; L-Lactate Dehydrogenase; MAP Kinase Kinase 4; Molsidomine; Myocytes, Smooth Muscle; Necrosis; Nitric Oxide Donors; Oxidants; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Pulmonary Artery | 2011 |
Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice.
Topics: Animals; Carcinoma, Lewis Lung; Cell Line, Tumor; Female; Humans; Inflammation Mediators; Interleukin-1beta; Lymphocytes, Tumor-Infiltrating; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Molsidomine; Myeloid Cells; Neoplasms, Experimental; Peroxynitrous Acid; T-Lymphocytes, Cytotoxic; Tumor Escape | 2011 |
The peroxynitrite donor 3-morpholinosydnonimine activates Nrf2 and the UPR leading to a cytoprotective response in endothelial cells.
Topics: Autophagy; Cell Line; Cell Nucleus; Cell Survival; Cytoprotection; DNA Fragmentation; Endothelial Cells; Gene Expression Profiling; Gene Expression Regulation; Heme Oxygenase-1; Humans; Molsidomine; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oxidants; Peroxynitrous Acid; Protein Transport; RNA Interference; Signal Transduction; Transcription Factor CHOP; Transcription, Genetic; Unfolded Protein Response | 2012 |
Taurine reduces nitrosative stress and nitric oxide synthase expression in high glucose-exposed human Schwann cells.
Topics: Antioxidants; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression Regulation; Glucose; Humans; Imidazolidines; Male; MAP Kinase Signaling System; Membrane Glycoproteins; Membrane Transport Proteins; Molsidomine; Nitrates; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitroprusside; Nitrosation; RNA, Messenger; Schwann Cells; Taurine; Thioctic Acid | 2012 |
Increased neuronal glutathione and neuroprotection in GTRAP3-18-deficient mice.
Topics: Analysis of Variance; Animals; Brain; Calcium-Binding Proteins; Carrier Proteins; Cysteine; Excitatory Amino Acid Transporter 3; Exploratory Behavior; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamic Acid; Glutathione; Glycine; Heat-Shock Proteins; Hippocampus; In Vitro Techniques; Maze Learning; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Molsidomine; Motor Activity; Neurons; Nitric Oxide Donors; Phenotype; Phosphopyruvate Hydratase; Time Factors | 2012 |
Conformational altered p53 as an early marker of oxidative stress in Alzheimer's disease.
Topics: Adult; Age of Onset; Alzheimer Disease; Biomarkers; Case-Control Studies; Demography; Female; Glutathione Peroxidase; Glutathione Reductase; Humans; Lymphocytes; Male; Middle Aged; Molsidomine; Mutation; Nitrosation; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Protein Conformation; Protein Unfolding; Superoxide Dismutase; Tumor Suppressor Protein p53 | 2012 |
Effects of maté tea intake on ex vivo LDL peroxidation induced by three different pathways.
Topics: Antioxidants; Beverages; Cholesterol, LDL; Copper Sulfate; Female; Humans; Ilex paraguariensis; Lipoxygenase; Molsidomine; Peroxynitrous Acid; Plant Leaves; Plant Preparations | 2009 |
Possible involvement of S-nitrosylation of brain cyclooxygenase-1 in bombesin-induced central activation of adrenomedullary outflow in rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenal Medulla; Animals; Benzoates; Bombesin; Brain; Catecholamines; Cysteine; Dithiothreitol; Dose-Response Relationship, Drug; Ethylmaleimide; Imidazoles; Injections, Intraventricular; Male; Molsidomine; Nitric Oxide Donors; Oxadiazoles; Paraventricular Hypothalamic Nucleus; Quinoxalines; Rats; Rats, Wistar; S-Nitrosothiols; Sulfhydryl Reagents | 2012 |
Protein kinase CK2 mediates peroxynitrite-induced heme oxygenase-1 expression in articular chondrocytes.
Topics: Animals; Apoptosis; Cartilage, Articular; Casein Kinase II; Cells, Cultured; Chondrocytes; Enzyme Induction; Female; Heme Oxygenase-1; Molsidomine; NF-E2-Related Factor 2; Peroxynitrous Acid; Phosphorylation; Rats; Rats, Sprague-Dawley | 2012 |
Peroxynitrite has potent pulmonary vasodilator activity in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Male; Molsidomine; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Penicillamine; Peroxynitrous Acid; Pulmonary Artery; Quinoxalines; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 2012 |
The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Cell Line, Tumor; Cognition; Coordination Complexes; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Molsidomine; Motor Activity; Neuroprotective Agents; Organometallic Compounds; Parkinson Disease; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Thiosemicarbazones | 2012 |
(13Z)- and (9Z)-lycopene isomers are major intermediates in the oxidative degradation of lycopene by cigarette smoke and Sin-1.
Topics: Adolescent; Adult; Antioxidants; Carotenoids; Chromatography, High Pressure Liquid; Humans; Lipoproteins, LDL; Lycopene; Middle Aged; Molsidomine; Nicotiana; Oxidation-Reduction; Peroxynitrous Acid; Reactive Oxygen Species; Smoke; Solutions; Stereoisomerism | 2012 |
Peroxynitrite donor SIN-1 alters high-affinity choline transporter activity by modifying its intracellular trafficking.
Topics: Cell Line, Transformed; Cell Line, Tumor; Choline; Clathrin; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Endocytosis; Endosomes; Hemicholinium 3; Humans; Leupeptins; Luminescent Proteins; Lysosomes; Membrane Transport Proteins; Molsidomine; Mutation; Neuroblastoma; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Protein Transport; rab5 GTP-Binding Proteins; Time Factors; Transfection; Tritium; Ubiquitination | 2012 |
Response of mitochondrial antioxidant system and respiratory pathways to reactive nitrogen species in pea leaves.
Topics: Antioxidants; Cell Respiration; Lipid Peroxidation; Mitochondria; Molsidomine; Nitric Oxide; Nitroso Compounds; Oxidative Stress; Pisum sativum; Plant Leaves; Reactive Nitrogen Species | 2013 |
Evaluation of novel antioxidant triterpenoid saponins from the halophyte Salicornia herbacea.
Topics: Antioxidants; Chenopodiaceae; Molecular Conformation; Molsidomine; Peroxynitrous Acid; Salt-Tolerant Plants; Saponins; Triterpenes | 2012 |
Comparative kinetics of thiol oxidation in two distinct free-radical generating systems: SIN-1 versus AAPH.
Topics: Amidines; Free Radicals; Kinetics; Molsidomine; Oxidation-Reduction; Sulfhydryl Compounds | 2012 |
Understanding the in-vivo relevance of S-nitrosothiols in insulin action.
Topics: Animals; Blood Glucose; Fasting; Insulin; Insulin Resistance; Male; Molsidomine; Nitric Oxide; Postprandial Period; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; S-Nitrosothiols | 2012 |
Modulation of transcriptional mineralocorticoid receptor activity by nitrosative stress.
Topics: Cells, Cultured; HEK293 Cells; Humans; Molsidomine; Nitric Oxide; Oxidative Stress; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; S-Nitroso-N-Acetylpenicillamine | 2012 |
Neoechinulin a imparts resistance to acute nitrosative stress in PC12 cells: a potential link of an elevated cellular reserve capacity for pyridine nucleotide redox turnover with cytoprotection.
Topics: Animals; Cell Survival; Cytoprotection; Glutathione; Indole Alkaloids; Molsidomine; Nitric Oxide; Nitro Compounds; Oxidation-Reduction; Oxidative Stress; Oxidoreductases; PC12 Cells; Piperazines; Rats; Sodium-Potassium-Exchanging ATPase; Transferases | 2012 |
Bicarbonate plays a critical role in the generation of cytotoxicity during SIN-1 decomposition in culture medium.
Topics: Animals; Bicarbonates; Cell Death; Chromatography, High Pressure Liquid; Culture Media; Cysteine; Glutathione; Mitochondria; Models, Biological; Molsidomine; PC12 Cells; Rats; Sodium Bicarbonate; Sodium Hydroxide; Sulfhydryl Compounds; Time Factors | 2012 |
Protection against peroxynitrite by pseudoperoxidase from Leishmania major.
Topics: Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Female; Hydrogen Peroxide; Leishmania major; Leishmaniasis, Cutaneous; Macrophage Activation; Macrophages; Membrane Proteins; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Molsidomine; Peroxidase; Peroxynitrous Acid; Protozoan Proteins | 2012 |
[Effects of peroxynitrite derived from nitric oxide on cultured bovine ocular explants].
Topics: Animals; Cattle; Cells, Cultured; Drug Evaluation, Preclinical; Eye; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Organ Culture Techniques; Oxidants; Peroxynitrous Acid | 2013 |
Neuroprotective effects of Cyperus rotundus on SIN-1 induced nitric oxide generation and protein nitration: ameliorative effect against apoptosis mediated neuronal cell damage.
Topics: Apoptosis; Blotting, Western; Caspase 3; Catalase; Cell Death; Cell Line, Tumor; Cyperus; Cytoprotection; DNA Damage; Dose-Response Relationship, Drug; HSP70 Heat-Shock Proteins; Humans; Lipid Peroxidation; Molsidomine; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Plant Extracts; Plants, Medicinal; Proto-Oncogene Proteins c-bcl-2; Rhizome; Superoxide Dismutase; Tyrosine | 2013 |
Tyrosine nitration provokes inhibition of sunflower carbonic anhydrase (β-CA) activity under high temperature stress.
Topics: Carbonic Anhydrases; Enzyme Activation; Helianthus; Models, Molecular; Molsidomine; Nitric Oxide; Protein Processing, Post-Translational; Stress, Physiological; Temperature; Tyrosine | 2013 |
Differential effects of the peroxynitrite donor, SIN-1, on atrial and ventricular myocyte electrophysiology.
Topics: Action Potentials; Animals; Atrial Function; Dogs; Enzyme Inhibitors; Female; Male; Molsidomine; Myocytes, Cardiac; Nitric Oxide Donors; Thapsigargin; Ventricular Function | 2013 |
Protective effects of Lagerstroemia speciosa on 3-morpholinosydnonimine (SIN-1)-induced oxidative stress in HIT-T15 pancreatic β cells.
Topics: Animals; Antioxidants; Cell Survival; Cricetinae; Insulin; Insulin Secretion; Insulin-Secreting Cells; Intracellular Space; Lagerstroemia; Lipid Peroxidation; Malondialdehyde; Mesocricetus; Molsidomine; Oxidative Stress; Plant Extracts; Plant Leaves; Protective Agents; Reactive Oxygen Species | 2013 |
The reduction of EPSC amplitude in CA1 pyramidal neurons by the peroxynitrite donor SIN-1 requires Ca2+ influx via postsynaptic non-L-type voltage gated calcium channels.
Topics: Animals; Butadienes; CA1 Region, Hippocampal; Calcium; Calcium Channels; Excitatory Postsynaptic Potentials; Ion Transport; Male; Molsidomine; Nitriles; Rats; Rats, Wistar | 2014 |
Reversal of SIN-1-induced eNOS dysfunction by the spin trap, DMPO, in bovine aortic endothelial cells via eNOS phosphorylation.
Topics: Animals; Aorta; Cattle; Cells, Cultured; Cyclic N-Oxides; Dose-Response Relationship, Drug; Endothelial Cells; HEK293 Cells; Humans; Molsidomine; Nitric Oxide Synthase Type III; Phosphorylation; Reactive Oxygen Species; Spin Labels | 2014 |
Posttranslational nitro-glycative modifications of albumin in Alzheimer's disease: implications in cytotoxicity and amyloid-β peptide aggregation.
Topics: Aged; Albumins; Alzheimer Disease; Amyloid beta-Peptides; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Female; Glycosylation; Humans; Male; Molsidomine; Neurons; Peptide Fragments; Protein Aggregates; Protein Processing, Post-Translational; tau Proteins; Trypsin; Tyrosine | 2014 |
Effect of oxidative stress on the expression of thin filament-associated proteins in gastric smooth muscle cells.
Topics: Animals; Gastrointestinal Motility; Gene Expression Regulation; Male; Microfilament Proteins; Molsidomine; Muscle, Smooth; Oxidative Stress; Rats; Rats, Sprague-Dawley; Stomach; Tyrosine | 2014 |
Topical combinations to treat microvascular dysfunction of chronic postischemia pain.
Topics: Administration, Topical; Adrenergic alpha-2 Receptor Agonists; Animals; Capillaries; Chemistry, Pharmaceutical; Chronic Pain; Clonidine; Dose-Response Relationship, Drug; Drug Combinations; Hyperalgesia; Hyperemia; Ischemia; Laser-Doppler Flowmetry; Male; Molsidomine; Nitric Oxide Donors; Ointments; Pain Measurement; Phosphatidic Acids; Phosphodiesterase Inhibitors; Rats; Rats, Long-Evans; Regional Blood Flow | 2014 |
Soluble guanylyl cyclase activators increase the expression of tolerance to morphine analgesic effect.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Male; Molsidomine; Morphine; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Photosensitizing Agents; Protoporphyrins; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Restriction Mapping; S-Nitroso-N-Acetylpenicillamine; Soluble Guanylyl Cyclase | 2014 |
MicroRNA-302 induces proliferation and inhibits oxidant-induced cell death in human adipose tissue-derived mesenchymal stem cells.
Topics: Adipose Tissue; Apoptosis; Base Sequence; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chemokine CCL5; Cobalt; Cyclin-Dependent Kinase Inhibitor p21; Down-Regulation; G1 Phase Cell Cycle Checkpoints; Heme Oxygenase-1; Humans; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Mesenchymal Stem Cells; MicroRNAs; Molsidomine; NF-E2-Related Factor 2; Oligonucleotides, Antisense; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Sequence Alignment; Transcriptome | 2014 |
Induction of heme oxygenase‑1 expression protects articular chondrocytes against cilostazol‑induced cellular senescence.
Topics: Animals; beta Catenin; beta-Galactosidase; Cell Survival; Cellular Senescence; Chondrocytes; Cilostazol; Collagen Type II; Deferoxamine; Female; Heme Oxygenase (Decyclizing); Molsidomine; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Small Interfering; Tetrazoles; Up-Regulation | 2014 |
Impact of SIN-1-derived peroxynitrite flux on endothelial cell redox homeostasis and bioenergetics: protective role of diphenyl diselenide via induction of peroxiredoxins.
Topics: Animals; Aorta; Benzene Derivatives; Cattle; Endothelial Cells; Energy Metabolism; Homeostasis; Membrane Potential, Mitochondrial; Mitochondria; Molsidomine; Organoselenium Compounds; Oxidation-Reduction; Peroxiredoxins; Peroxynitrous Acid | 2015 |
Peroxynitrite-mediated nitrosative stress decreases motility and mitochondrial membrane potential in human spermatozoa.
Topics: Adult; Benzimidazoles; Carbocyanines; Cell Survival; Fluorescent Dyes; Humans; Male; Membrane Potential, Mitochondrial; Molsidomine; Oxidative Stress; Peroxynitrous Acid; Rhodamines; Semen Analysis; Spectrometry, Fluorescence; Sperm Motility; Spermatozoa | 2015 |
Neuroprotective effect of 3-morpholinosydnonimine against Zn²⁺-induced PC12 cell death.
Topics: Animals; Cell Death; Enzyme Activation; Glutathione Disulfide; Glutathione Reductase; Humans; Molsidomine; Neurons; Neuroprotective Agents; PC12 Cells; Rats; Zinc | 2015 |
Interaction between hydrogen sulfide-induced sulfhydration and tyrosine nitration in the KATP channel complex.
Topics: Animals; Calcium Chloride; CHO Cells; Cricetulus; Cysteine; Dose-Response Relationship, Drug; Ileum; KATP Channels; Mice; Molsidomine; Muscle Contraction; Muscle, Smooth; Mutation; Peroxynitrous Acid; Protein Processing, Post-Translational; Signal Transduction; Sulfides; Sulfonylurea Receptors; Transfection; Tyrosine | 2015 |
Myeloperoxidase scavenges peroxynitrite: A novel anti-inflammatory action of the heme enzyme.
Topics: Aniline Compounds; Anti-Inflammatory Agents; Catechin; Fluoresceins; Halogenation; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; Molsidomine; Nitrites; Oxidants; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid; Tyrosine | 2015 |
Design, green synthesis and pharmacological evaluation of novel 5,6-diaryl-1,2,4-triazines bearing 3-morpholinoethylamine moiety as potential antithrombotic agents (.).
Topics: Animals; Blood Platelets; Drug Design; Female; Fibrinolytic Agents; Humans; Models, Molecular; Molecular Docking Simulation; Molsidomine; Platelet Adhesiveness; Platelet Aggregation; Rats; Rats, Wistar; Structure-Activity Relationship; Triazines | 2016 |
Oxidation and Tyrosine Nitration Induce Structural Changes and Inhibits Plasmodium falciparum Falcipain-2 Activity In Vitro.
Topics: Antimalarials; Cysteine Endopeptidases; Hydrogen Peroxide; Molsidomine; Nitric Oxide; Oxidation-Reduction; Plasmodium falciparum; Protein Structure, Secondary; Sodium Nitrite; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2016 |
Nitrosative stress by peroxynitrite impairs ATP production in human spermatozoa.
Topics: Adenosine Triphosphate; Antimetabolites; Deoxyglucose; Glycolysis; Humans; Male; Membrane Potential, Mitochondrial; Mitochondria; Molsidomine; Oxidative Phosphorylation; Oxidative Stress; Peroxynitrous Acid; Rotenone; Sperm Motility; Spermatozoa; Uncoupling Agents | 2017 |
Thiol oxidation by nitrosative stress: Cellular localization in human spermatozoa.
Topics: Fluorescent Dyes; Humans; Male; Molsidomine; Oxidation-Reduction; Peroxynitrous Acid; Semen Analysis; Sperm Motility; Spermatozoa; Sulfhydryl Compounds | 2016 |
Increasing the availability of l-arginine and nitric oxide increases sensitivity of nitrous oxide (N2O)-insensitive inbred mice to N2O-induced antinociception.
Topics: Abdominal Pain; Analgesics; Analysis of Variance; Animals; Arginine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrous Oxide; Pain Threshold; Species Specificity | 2016 |
Effect of short-term exposure of cumulus-oocyte complex to 3-morpholinosydnonimine on in vitro embryo development and gene expression in cattle.
Topics: Animals; Cattle; Cumulus Cells; Embryo Culture Techniques; Female; Gene Expression Regulation, Developmental; Molsidomine; Oocytes | 2016 |
New approach to molsidomine active metabolites coming from the results of 2 models of experimental cardiology.
Topics: Animals; Anti-Asthmatic Agents; Arrhythmias, Cardiac; Creatine Kinase; Disease Models, Animal; Hemodynamics; Isolated Heart Preparation; Lidocaine; Male; Molsidomine; Nitrosamines; Rats; Reperfusion Injury | 2017 |
Cross-talk between lipid and protein carbonylation in a dynamic cardiomyocyte model of mild nitroxidative stress.
Topics: Aldehydes; Animals; Autophagy; Ketones; Lipid Peroxidation; Molsidomine; Myocytes, Cardiac; Nitrogen; Oxidative Stress; Proteasome Endopeptidase Complex; Protein Carbonylation; Proteolysis; Rats; Reactive Nitrogen Species; Reactive Oxygen Species | 2017 |
Development of High-Throughput Method for Measurement of Vascular Nitric Oxide Generation in Microplate Reader.
Topics: Acetylcholine; Animals; Aorta; Buffers; Endothelium, Vascular; Fluoresceins; Fluorescent Dyes; High-Throughput Screening Assays; Limit of Detection; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Pyruvaldehyde; Rats; Rats, Wistar; Reproducibility of Results; Tissue Culture Techniques | 2017 |
Triosephosphate isomerase tyrosine nitration induced by heme-NaNO
Topics: Acetophenones; Anthracenes; Antioxidants; Circular Dichroism; Flavonoids; Heme; Hydrogen Peroxide; Indicators and Reagents; Kinetics; Molsidomine; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Phytochemicals; Protein Processing, Post-Translational; Protein Structure, Secondary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sodium Nitrite; Triose-Phosphate Isomerase; Tyrosine | 2017 |
Reactive nitrogen species control apoptosis and autophagy in K562 cells: implication of TAp73α induction in controlling autophagy.
Topics: Apoptosis; Autophagy; Humans; K562 Cells; Molsidomine; Nitroso Compounds; Peroxynitrous Acid; Reactive Nitrogen Species; Tumor Protein p73 | 2018 |
A comparative study of using free radical generators in the testing of chosen oxidative stress parameters in the different types of cells.
Topics: A549 Cells; Amidines; Animals; Cell Line; CHO Cells; Cricetulus; Humans; Keratinocytes; Mice; Molsidomine; Oxidative Stress; RAW 264.7 Cells; Skin Neoplasms; Sodium Compounds; Sulfates; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2018 |
FGF8 and FGFR3 are up-regulated in hypertrophic chondrocytes: Association with chondrocyte death in deep zone of Kashin-Beck disease.
Topics: Animals; Biomarkers; Cartilage, Articular; Cell Death; Cell Differentiation; Cell Line; Child; Child, Preschool; Chondrocytes; Disease Models, Animal; Fibroblast Growth Factor 8; Humans; Hypertrophy; Kashin-Beck Disease; Male; Molsidomine; Rats, Sprague-Dawley; Receptor, Fibroblast Growth Factor, Type 3; Up-Regulation | 2018 |
The Nitric Oxide Donor SIN-1-Produced Panic-Like Behaviour And Fear-Induced Antinociception Are Modulated By NMDA Receptors In The Anterior Hypothalamus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Fear; Hypothalamus, Anterior; Male; Mice; Mice, Inbred C57BL; Microinjections; Molsidomine; Nitric Oxide Donors; Panic; Receptors, N-Methyl-D-Aspartate | 2018 |
3-morpholinosydnonimine (SIN-1)-induced oxidative stress leads to necrosis in hypertrophic chondrocytes in vitro.
Topics: Animals; Apoptosis; Cartilage; Case-Control Studies; Cell Line; Cell Survival; Chondrocytes; Dose-Response Relationship, Drug; Humans; Hypertrophy; Kashin-Beck Disease; Mice; Molsidomine; Necrosis; Osteoarthritis; Oxidants; Oxidative Stress; Reactive Nitrogen Species; Reactive Oxygen Species; Time Factors; Tissue Engineering | 2018 |
Imaging and Quantification of Secreted Peroxynitrite at the Cell Surface by a Streptavidin-Biotin-Controlled Binding Probe.
Topics: Animals; Biotin; Carbocyanines; Cell Membrane; Enzyme Activators; Fluorescent Dyes; Gene Expression; Interferon-gamma; Lipopolysaccharides; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Phosphatidylinositol 4,5-Diphosphate; RAW 264.7 Cells; Streptavidin; Tetradecanoylphorbol Acetate | 2018 |
Hydroxysafflor Yellow A Shows Protection against PPAR
Topics: Animals; Cell Death; Cells, Cultured; Chalcone; Hippocampus; Male; Molsidomine; Neurons; Neuroprotection; Neuroprotective Agents; Nitrosation; PPAR gamma; Quinones; Rats, Sprague-Dawley | 2018 |
Nitric oxide triggers the assembly of "type II" stress granules linked to decreased cell viability.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Apoptosis Regulatory Proteins; Arsenites; Cell Line, Tumor; Cell Survival; Cytoplasmic Granules; Eukaryotic Initiation Factor-2; Eukaryotic Initiation Factor-3; Eukaryotic Initiation Factor-4F; Fibroblasts; Gene Expression Regulation; Humans; Mice; Mitochondria; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Osteoblasts; Protein Biosynthesis; Reactive Oxygen Species; Sodium Compounds; Stress, Physiological; TOR Serine-Threonine Kinases | 2018 |
Force generated by myosin cross-bridges is reduced in myofibrils exposed to ROS/RNS.
Topics: Actins; Animals; Isometric Contraction; Molsidomine; Myofibrils; Myosins; Nitric Oxide Donors; Oxidants; Oxidative Stress; Peroxynitrous Acid; Psoas Muscles; Rabbits; Tissue Culture Techniques | 2019 |
Deletion of P2X7 Receptor Decreases Basal Glutathione Level by Changing Glutamate-Glutamine Cycle and Neutral Amino Acid Transporters.
Topics: Acetylcysteine; Amino Acid Transport System ASC; Amino Acid Transport Systems, Neutral; Animals; Gene Deletion; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Glutathione; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Minor Histocompatibility Antigens; Molsidomine; Receptors, Purinergic P2X7 | 2020 |
Peroxynitrite-Induced Intracellular Ca2+ Depression in Cardiac Myocytes: Role of Sarco/Endoplasmic Reticulum Ca2+ Pump.
Topics: Animals; Caffeine; Calcium; Endoplasmic Reticulum; Intracellular Space; Male; Membrane Transport Proteins; Molsidomine; Myocardial Contraction; Myocytes, Cardiac; Peroxynitrous Acid; Phosphorylation; Rats, Wistar; Tetracaine | 2019 |
Red Blood Cell Peroxynitrite Causes Endothelial Dysfunction in Type 2 Diabetes Mellitus via Arginase.
Topics: Animals; Aorta; Arginase; Diabetes Mellitus, Type 2; Endothelium, Vascular; Erythrocytes; Female; Humans; Male; Middle Aged; Models, Biological; Molsidomine; Peroxynitrous Acid; Rats, Sprague-Dawley; Rats, Wistar | 2020 |
Peroxynitrite decomposition catalyst enhances respiratory function in isolated brain mitochondria.
Topics: Animals; Brain; Catalysis; Cell Respiration; Membrane Potential, Mitochondrial; Metalloporphyrins; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Molsidomine; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Reactive Oxygen Species; Superoxides | 2021 |
Nitric oxide-mediated defensive and antinociceptive responses organised at the anterior hypothalamus of mice are modulated by glutamatergic inputs from area 24b of the cingulate cortex.
Topics: Analgesia; Animals; Behavior, Animal; Fear; Gyrus Cinguli; Hypothalamus, Anterior; Mice; Mice, Inbred C57BL; Microinjections; Molsidomine; Neural Pathways; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Donors; Pain Perception; Receptors, N-Methyl-D-Aspartate | 2021 |
Design and synthesis of novel hybrid sydnonimine and prodrug useful for glaucomatous optic neuropathy.
Topics: Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Glaucoma; Humans; Hydrogen Peroxide; Intraocular Pressure; Molecular Structure; Nitric Oxide; Optic Nerve Diseases; Oxidative Stress; Prodrugs; Reactive Oxygen Species; Structure-Activity Relationship; Sydnones | 2016 |