linsidomine has been researched along with cyclic gmp in 241 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (8.30) | 18.7374 |
| 1990's | 157 (65.15) | 18.2507 |
| 2000's | 60 (24.90) | 29.6817 |
| 2010's | 4 (1.66) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Braun, MS; Heckenberger, RE; Klockenbusch, W; Schröder, H; Schrör, K; Strobach, H | 1 |
| Butt, E; Geiger, J; Nolte, C; Sage, SO; Walter, U | 1 |
| Bockaert, J; Desagher, S; Deshager, S; Fagni, L; Manzoni, O; Marin, P; Prezeau, L | 1 |
| Bosia, A; Bussolino, F; Garbarino, G; Ghigo, D; Heller, R; Pescarmona, G; Till, U | 1 |
| Arvola, P; Huhtala, H; Metsä-Ketelä, T; Pörsti, I; Vapaatalo, H; Vuorinen, P | 1 |
| Braida, C; Holzmann, S; Kukovetz, WR; Pöch, G | 1 |
| Chap, H; Gassama-Diagne, A; Simon, MF | 1 |
| Gryglewski, RJ; Salvemini, D; Taylor, GW; Vane, JR; Zembowicz, A | 1 |
| Duarte, ID; Ferreira, SH | 1 |
| Bucher, B; Ouedraogo, S; Paya, D; Stoclet, JC; Tschöpl, M | 1 |
| Vuorinen, P | 1 |
| Howlett, A; Klein, C; Tao, Y | 1 |
| Schini, VB; Vanhoutte, PM | 2 |
| Bourchier, RG; Gloviczki, P; Komori, K; Schini, VB; Vanhoutte, PM | 1 |
| Garthwaite, J; Southam, E | 2 |
| Duarte, ID; Ferreira, SH; Lorenzetti, BB | 1 |
| Ney, P; Schröder, H; Schrör, K; Woditsch, I | 2 |
| Bowen, R; Haslam, RJ | 1 |
| Förster, S; Schröder, H; Schrör, K; Woditsch, I | 2 |
| Laustiola, KE; Manninen, V; Metsä-Ketelä, T; Pörsti, I; Vapaatalo, H; Vuorinen, P | 1 |
| Alam, AS; Datta, HK; Hecker, M; Lidbury, PS; MacIntyre, I; Moonga, BS; Vane, JR; Zaidi, M | 1 |
| Ney, P; Schröder, H; Schrör, K | 1 |
| Gerzer, R; Heim, JM; Karrenbrock, B | 1 |
| Haslam, RJ; Maurice, DH | 1 |
| Chap, H; Simon, MF | 1 |
| Drummer, C; Gerzer, R; Heim, JM; Karrenbrock, B | 1 |
| Bult, H; Fret, HR; Herman, AG | 1 |
| Vanhoutte, PM | 1 |
| Bassenge, E; Mülsch, A | 1 |
| Holzmann, S; Kukovetz, WR | 5 |
| Katusic, ZS; Vanhoutte, PM | 1 |
| Bassenge, E; Busse, R; Mülsch, A; Pohl, U | 1 |
| Bassenge, E; Busse, R; Mülsch, A | 1 |
| Chap, H; Douste-Blazy, L; Simon, MF | 1 |
| Kukovetz, WR; Schmidt, K | 1 |
| Bourgoin, S; Harbon, S; Leiber, D | 1 |
| Cingolani, H; Rinaldi, G | 1 |
| Giles, WR; Han, X; Shimoni, Y | 1 |
| Bockaert, J; Culcasi, M; Gaven, F; Lafon-Cazal, M; Pietri, S | 1 |
| Aleppo, G; Canonico, PL; Scapagnini, U; Sortino, MA | 1 |
| Cunningham, JM; Delaney, CA; Elphick, MR; Green, IC; Green, MH; Mabley, JG | 1 |
| Iadecola, C; Xu, X; Zhang, F | 1 |
| Garg, LC; Guzman, NJ; Madsen, KM; Tisher, CC; Tojo, A | 1 |
| Dymshitz, J; Vasko, MR | 1 |
| Akesson, B; Lundquist, I; Panagiotidis, G; Rydell, EL | 1 |
| Bara, A; Busse, R; Mülsch, A; Schini-Kerth, V | 1 |
| Bockaert, J; Fagni, L; Lafon-Cazal, M; Lerner-Natoli, M; Manzoni, O; Rondouin, G | 1 |
| Patel, MJ; Rimele, TJ; Rose, DA; Wiseman, JS; Wypij, DM | 1 |
| Bousquet, J; Dugas, B; Paul-Eugène, N; Pène, J | 1 |
| Grünberg, B; Negrescu, E; Siess, W | 1 |
| Eneroth, PH; Nilsson, CG; Xiao, L | 1 |
| Darius, H; Fisch, A; Meyer, J; Michael-Hepp, J | 1 |
| Bosmans, JM; Bult, H; Herman, AG; Vrints, CJ | 1 |
| Maronde, E; Mayer, B; Middendorff, R; Olcese, J | 1 |
| Bonaventura, J; Doty, E; Haney, AF; Weinberg, JB | 1 |
| Barnes, PJ; Belvisi, MG; Tadjkarimi, S; Ward, JK; Yacoub, MH | 1 |
| Hughes, H; Joly, GA; Schini, VB; Vanhoutte, PM | 1 |
| Cunningham, JM; Delaney, CA; Green, IC; Karmiris, V; Southern, C | 1 |
| Bosia, A; Bussolino, F; Calvino, R; Gasco, A; Ghigo, D; Heller, R; Pescarmona, GP; Till, U | 1 |
| Alanko, J; Lähteenmäki, T; Mucha, I; Riutta, A; Sievi, E; Vapaatalo, H | 1 |
| Neumannova, V; Ponka, P; Richardson, DR | 1 |
| Alanko, J; Mucha, I; Riutta, A; Vapaatalo, H | 1 |
| Johnston, HM; Morris, BJ | 2 |
| Bialecki, RA; Stinson-Fisher, C | 1 |
| Bénardeau, A; Fischmeister, R; Hatem, S; Kirstein, M; Mercadier, JJ; Rivet-Bastide, M | 1 |
| Bouriquet, N; Casellas, D | 1 |
| Illiano, S; Mombouli, JV; Olmos, L; Vanhoutte, PM | 1 |
| Arias, IM; Dufour, JF; Turner, TJ | 1 |
| Barnes, CS; Coker, SJ | 1 |
| Andre, A; Andriantsitohaina, R; Lagaud, GJ; Muller, B; Stoclet, JC | 1 |
| Belhassen, L; Fischmeister, R; Méry, PF; Pavoine, C; Pecker, F | 1 |
| Brian, JE; Hicks, KK; Kennedy, RH; Seifen, E | 1 |
| Cunningham, JM; Delaney, CA; Green, IC; Mabley, JG | 1 |
| Drescher, P; Madsen, PO; Sparwasser, C; Will, JA | 1 |
| Madison, DV; Meffert, MK; Schulman, H; Schuman, EM | 1 |
| Janigro, D; Nguyen, TS; West, GA; Winn, HR | 1 |
| Mohaupt, M; Schoecklmann, HO; Schulze-Lohoff, E; Sterzel, RB | 1 |
| Hardy, E; Horn, EH; Rubin, PC | 1 |
| Becquet, F; Courtois, Y; Goureau, O | 1 |
| Hess, DT; Patterson, SI; Skene, JH; Smith, DS | 1 |
| Schrör, K; Strobach, H; Weber, AA | 1 |
| Kubes, P | 1 |
| Arnal, JF; Michel, JB; Schott, C; Stoclet, JC | 1 |
| Jones, KA; Katusić, ZS; Lorenz, RR; Sieck, GC; Warner, DO | 1 |
| Busse, R; Hecker, M; Mordvintcev, PI; Mülsch, A; Vanin, AF | 1 |
| Cosentino, F; Katusić, ZS; Sill, JC | 1 |
| Kubes, P; Payne, D | 1 |
| Kankaanranta, H; Metsä-Ketelä, T; Moilanen, E; Vapaatalo, H; Vuorinen, P | 1 |
| Kurtz, A; Schricker, K | 1 |
| Andersson, KE; Fridstrand, M; Hedlund, H; Holmquist, F | 1 |
| Bath, PM | 1 |
| Grünberg, B; Kratzer, MA; Lorenz, R; Negrescu, EV; Siess, W | 1 |
| Chaudhuri, G; Chopra, M; Gryglewski, R; Ignarro, LJ; Radziszewski, W; Zembowicz, A | 1 |
| Balligand, JL; Han, X; Kelly, RA; Kobzik, L; Smith, TW | 1 |
| Brutsaert, DL; Mohan, P; Paulus, WJ; Sys, SU | 1 |
| Ballejo, G; De Oliveira, RB; Martins, SL | 1 |
| Andersson, KE; Persson, K; Waldeck, K | 1 |
| Sadoff, JD; Scholz, PM; Tse, J; Weiss, HR | 1 |
| Pieper, GM; Tseng, LF; Xu, JY | 1 |
| Bucher, B; Butt, E; Genieser, HG; Huggins, JP; Pöhler, D | 1 |
| Fandrey, J; Hoffmann, G; Schobersberger, W | 1 |
| Pehl, U; Schmid, HA | 1 |
| Ebihara, Y; Karmazyn, M | 1 |
| Allescher, HD; Huber, A; Kurjak, M; Schusdziarra, V; Trudrung, P | 1 |
| Ikeda, M; Ikeda, U; Kano, S; Minota, S; Shimada, K; Takahashi, M | 1 |
| Nurminen, ML; Vapaatalo, H | 1 |
| Garland, CJ; Hurrell, A; Jeremy, JY; Plane, F | 1 |
| Colasanti, M; Lauro, GM; Merante, A; Musci, G; Venturini, G | 1 |
| Li, L; Paakkari, I; Redemann, B; Vaali, K; Vapaatalo, H | 1 |
| Becker, AJ; Jonas, U; Machtens, S; Stief, CG; Truss, MC; Uckert, S | 1 |
| Boss, GR; Pascual, FE; Pilz, RB; Suhasini, M | 1 |
| Cermak, R; Forssmann, WG; Hirsch, JR; Kleta, R; Kruhøffer, M; Kuhn, M; Schafer, JA; Schlatter, E; Sun, D | 1 |
| Hempel, A; Hölschermann, H; Noll, T; Piper, HM | 1 |
| Funayama, H; Ikeda, U; Kano, S; Masuyama, J; Shimada, K; Takahashi, M | 1 |
| Chen, AF; Crotty, TB; Katusic, ZS; Kinoshita, H; O'Brien, T; Pompili, VJ; Spector, DJ; Tsutsui, M | 1 |
| Naim, KL; Rabindranauth, P; Sadoff, JD; Scholz, PM; Tse, J; Weiss, HR | 1 |
| Christodoulides, N; Durante, W; Kroll, MH; Peyton, KJ; Schafer, AI | 1 |
| Hemmens, B; Leopold, E; Mayer, B; Pfeiffer, S; Schmidt, K; Werner, ER | 1 |
| Iadecola, C; Yang, G | 1 |
| Holm, P; Kankaanranta, H; Knowles, RG; Kosonen, O; Moilanen, E; Vuorinen, P | 1 |
| Katusic, ZS; Onoue, H | 2 |
| Baux, G; Fossier, P; Mothet, JP; Schirar, A; Tauc, L | 1 |
| Nishizawa, S; Ryu, H; Uemura, K; Yamamoto, S; Yokoyama, T | 1 |
| Brown, HF; Casadei, B; Lei, M; Musialek, P; Paterson, DJ | 1 |
| Dietl, P; Friedrich, F; Hoffmann, G; Schobersberger, W; Völkl, H | 1 |
| Kinoshita, M; Liu, Q; Matsumoto, T; Nakae, I; Omura, T; Takahashi, M; Takaoka, A | 1 |
| Barkin, M; Barnett, CC; Moore, EE; Offner, PJ; Partrick, DA; Silliman, CC | 1 |
| Azam, M; Danziger, RS; Gupta, G; Yang, L | 1 |
| Nishizawa, S; Uemura, K; Yamamoto, S; Yokoyama, T | 1 |
| Corriveau, CC; Danner, RL; Madara, PJ; Tropea, MM; Van Dervort, AL; Wesley, RA | 1 |
| Eu, JP; Meissner, G; Stamler, JS; Xu, L | 1 |
| Oberle, S; Polte, T; Schröder, H | 1 |
| Cantabrana, B; Hidalgo, A; Menéndez Antolin, L; Pérez Vallina, JR; Sánchez, M | 1 |
| Chang, ES; Graubard, K; Scholz, NL; Truman, JW | 1 |
| Alm, P; Andersson, KE; Persson, K; Uvelius, B | 1 |
| Higuchi, S; Nakasone, C; Noguchi, K; Shigenobu, K; Shijuku, T; Takahashi, K; Tanaka, H; Tanaka, Y | 1 |
| Brandi, ML; MacIntyre, I; Mancini, L; Moradi-Bidhendi, N | 1 |
| Gauer, S; Pröls, F; Schoecklmann, HO; Sterzel, RB; Yao, J | 1 |
| Bode-Böger, SM; Böger, RH; Frölich, JC; Galland, A | 1 |
| Hagino, Y; Matsui, S; Nomura, H; Nomura, T; Ohtsuki, M; Sumi-Ichinose, C | 1 |
| Cohen, RA; Garland, CJ; Jeremy, JY; Plane, F; Wiley, KE | 1 |
| Gong, GX; Scholz, PM; Tse, J; Weiss, HR | 1 |
| Allescher, HD; Franck, H; Puschmann, A; Schusdziarra, V; Storr, M | 1 |
| Howlett, A; Klein, C; Najafi, L; Shipley, S; Tao, YP | 1 |
| Fein, A; Tertyshnikova, S; Yan, X | 1 |
| Abderrahmane, A; Cadieux, A; Dumoulin, M; Garon, J; Rousseau, E; Salvail, D | 1 |
| Fujino, MA; Hosoda, K; Owyang, C; Takahashi, T | 1 |
| LaPointe, MC; Marsh, JD; Ritchie, RH; Schiebinger, RJ | 1 |
| Allescher, HD; Franck, H; Huber, A; Ruth, P; Schusdziarra, V; Storr, M; Trudrung, P | 1 |
| Lähteenmäki, T; Sievi, E; Vapaatalo, H | 1 |
| Brüne, B; Callsen, D; Pfeilschifter, J | 1 |
| Hinz, B; Schröder, H | 2 |
| de Vente, J; Grillner, S; Hökfelt, T; Steinbusch, H; Xu, ZQ | 1 |
| Fernández-Tomé, P; Leza, JC; Lizasoain, I; Lorenzo, P; Moro, MA | 1 |
| Alm, P; Andersson, KE; Persson, K; Werkström, V | 1 |
| Miyakoshi, M; Murayama, T; Naganuma, T; Nomura, Y | 1 |
| Cui, M; Lin, Q; Peng, YB; Willis, WD; Wu, J | 1 |
| Rehder, V; Van Wagenen, S | 2 |
| Charles, SL; Salt, TE; Shaw, PJ | 1 |
| Chesnais, JM; Fischmeister, R; Méry, PF | 2 |
| Immenschuh, S; Iwahara, S; Ramadori, G; Stritzke, J | 1 |
| Chen, SJ; Wu, CC; Yen, MH | 1 |
| Kankaanranta, H; Kosonen, O; Malo-Ranta, U; Moilanen, E | 1 |
| Côrtes, SF; Freitas, MR; Lemos, VS; Lino, YD; Muller, B; Queiroga, CE | 1 |
| Baribeau, J; Berkenbosch, JW; Perreault, T | 1 |
| Ahmad, M; Alm, P; Andersson, KE; Aszòdi, A; Fässler, R; Hedlund, P; Ny, L; Pfeifer, A | 1 |
| Leone, RJ; Scholz, PM; Straznicka, M; Weiss, HR | 1 |
| Cox, G; Janssen, LJ; Keshavjee, S; Lu-Chao, H; Premji, M | 1 |
| Abate, A; Dennery, PA; Polte, T; Schröder, H | 1 |
| Chen, Q; Gole, M; Gow, AJ; Ischiropoulos, H; Lee, VM; Themistocleous, M | 1 |
| Chen, JW; Eatock, RA | 1 |
| Grosser, N; Schröder, H | 1 |
| Cai, L; Ingram, AJ; James, L; Ly, H; Scholey, JW; Thai, K | 1 |
| Andersson, K; Fujiwara, M; Persson, K | 1 |
| Choi, MS; Choi, SH; Kim, KH; Kim, YG; Park, KH; Yoon, JM | 1 |
| Ekelund, UE; Georgakopoulos, D; Hare, JM; Harrison, RW; Isoda, T; Kass, DA; Ozaki, M; Paolocci, N; Vandegaer, K | 1 |
| Casadei, B; Musialek, P; Paterson, DJ; Rigg, L; Terrar, DA | 1 |
| Prado, WA; Sousa, AM | 1 |
| Morris, R; Thippeswamy, T | 1 |
| Decking, UK; Schrader, J; Stumpe, T | 1 |
| Edelstein, C; Gengaro, P; Lelamali, K; Schrier, RW; Wang, W | 1 |
| Buxton, IL; Kaiser, RA; Malmquist, NA; Tichenor, S | 1 |
| McKoy, ML; Simon, OR | 1 |
| Kim, JH; Kim, SB; Lee, SK; Park, JS; Park, SK; Yang, WS | 1 |
| Mazza, R; Pellegrino, D; Randall, DJ; Sprovieri, E; Tota, B | 1 |
| Bourreau, JP; Deng, C; Shan, Q; Yin, X | 1 |
| Kim, CS; Kim, SB; Lee, SK; Park, JS; Park, SK; Yang, WS | 1 |
| Graier, WF; Groschner, K; Malli, R; Schmidt, K; Thyagarajan, B | 1 |
| Ckert, S; Frlich, Jr; Jonas, U; Machtens, S; Stief, CG; Tsikas, D | 1 |
| Brandes, RP; Gambaryan, S; Holtwick, R; Kuhn, M; Sabrane, K; Voss, M | 1 |
| Ferreira, SH; Parada, CA; Vivancos, GG | 1 |
| Buxton, IL; Malmquist, NA; Tichenor, SD | 1 |
| Chen, Z; Li, R; Wang, W; Xiao, J | 1 |
| Alloatti, G; Bedendi, I; Gallo, MP; Levi, RC; Malan, D; Marcantoni, A | 1 |
| Delogu, MR; Desole, MS; Esposito, G; Miele, E; Miele, M; Migheli, R; Mura, MP; Rocchitta, G; Serra, PA; Taras, MG | 1 |
| Jun, CH; Lee, TS; Sohn, UD | 1 |
| Sadan, G; Tasatargil, A | 1 |
| Déciga-Campos, M; López-Muñoz, FJ | 1 |
| Antunes, E; De Nucci, G; Marcondes, S; Moreira, J; Thomazzi, SM | 1 |
| Berndt, G; Grosser, N; Hoogstraate, J; Schröder, H | 1 |
| Cho, KW; Cui, X; Jin, JY; Kim, SH; Kim, SM; Kim, SZ; Lee, HS; Wen, JF | 1 |
| Brading, AF; Deka, DK | 1 |
| Flammer, J; Haefliger, IO; Wu, R; Yao, K | 1 |
| Correia, NC; Guarino, MP; Lautt, WW; Macedo, MP | 1 |
| Palmerini, CA; Pellegrino, D; Tota, B | 1 |
| Eldred, WD; Yu, D | 1 |
| Pellegrino, D; Randall, DJ; Tota, B | 1 |
| Elmedal Laursen, B; Mulvany, MJ; Simonsen, U | 1 |
| Doke, N; Kawakita, K; Saito, S; Yamamoto-Katou, A; Yoshioka, H | 1 |
| Bonatti, J; Fersterer, J; Hammerer-Lercher, A; Hoefer, D; Holzmann, S; Mair, J; Puschendorf, B; Ruttmann, E | 1 |
| Dirnagl, U; Dreier, JP; Lindauer, U; Scheckenbach, KE | 1 |
| Carletti, F; D'Agostino, S; Ferraro, G; Rizzo, V; Sardo, P | 1 |
| Almanza, A; Navarrete, F; Soto, E; Vega, R | 1 |
| Faggio, C; Pidalà, P; Trischitta, F | 1 |
| Banasik, M; Bednarska, K; Jastrzembska, K; Klink, M; Sulowska, Z | 1 |
| Je, HD; Lee, YP; Shin, CY; Sohn, UD; Song, HJ | 1 |
| Hashitani, H; Hayase, M; Kohri, K; Sasaki, S; Suzuki, H; Yanai, Y | 1 |
| Kiagiadaki, F; Mastrodimou, N; Thermos, K | 1 |
| D'angelo, V; Galati, S; Martorana, A; Procopio, T; Sancesario, G; Scarnati, E; Stanzione, P; Stefani, A | 1 |
| Acierno, R; Amelio, D; Gattuso, A; Guerrieri, A; Mannarino, C; Tota, B | 1 |
| Amelio, D; Cerra, MC; Garofalo, F; Pellegrino, D; Sidell, BD; Tota, B | 1 |
| Carletti, F; D'Agostino, S; Ferraro, G; Lonobile, G; Rizzo, V; Sardo, P | 1 |
| McNamara, JC; Ribeiro, MR | 1 |
| Kim, JM; Kim, SY; Koo, JY; Koo, YK; Oh, D; Park, S; Yun-Choi, HS | 1 |
| Altun, A; Bagcivan, I; Durmus, N; Sarac, B; Sencan, M; Turan, M | 1 |
| Aggarwal, S; Black, SM; Datar, S; Fineman, JR; Fratz, S; Gross, CM; Kalkan, G; Kumar, S; Oishi, P; Schreiber, C | 1 |
| Aldinucci, C; Coppo, L; Di Giuseppe, D; Di Simplicio, P; Di Stefano, A; Frosali, S; Margaritis, A; Pessina, G; Priora, R; Summa, D | 1 |
| Arner, A; de Sá, VP; Ekblad, E; Harnek, J; Stenram, U; Zoucas, E | 1 |
1 review(s) available for linsidomine and cyclic gmp
| Article | Year |
|---|---|
Effects of cytokines and nitric oxide donors on insulin secretion, cyclic GMP and DNA damage: relation to nitric oxide production.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cell Line; Cells, Cultured; Cyclic GMP; Cytokines; DNA; DNA Damage; Free Radicals; Insulin; Insulin Secretion; Interleukin-1; Islets of Langerhans; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Vasodilator Agents | 1994 |
2 trial(s) available for linsidomine and cyclic gmp
| Article | Year |
|---|---|
Isosorbidedinitrate and SIN-1 as dilators of human coronary arteries and platelet inhibitors.
Topics: Angina Pectoris; Blood Pressure; Coronary Vessels; Cyclic AMP; Cyclic GMP; Double-Blind Method; Female; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Molsidomine; Platelet Aggregation; Platelet Aggregation Inhibitors; Vasodilator Agents | 1995 |
Differential inhibition of human platelet aggregation and thromboxane A2 formation by L-arginine in vivo and in vitro.
Topics: Adult; Antithrombins; Arginine; Blood Platelets; Cyclic GMP; Enzyme Inhibitors; Humans; In Vitro Techniques; Infusions, Intravenous; Male; Molsidomine; Nitric Oxide Synthase; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane A2; Thromboxane B2; Thromboxanes | 1998 |
238 other study(ies) available for linsidomine and cyclic gmp
| Article | Year |
|---|---|
Prostacyclin rather than nitric oxide lowers human umbilical artery tone in vitro.
Topics: Arginine; Bradykinin; Cyclic GMP; Epoprostenol; Female; Histamine; Humans; Iloprost; In Vitro Techniques; Indomethacin; Molsidomine; Muscle Contraction; Nitric Oxide; Nitroarginine; Serotonin; Umbilical Arteries; Vasodilation | 1992 |
Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets.
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Calcium; Cell Compartmentation; Cyclic GMP; Cytoplasm; Humans; In Vitro Techniques; Ion Channel Gating; Kinetics; Molsidomine; Nitroprusside; Phosphoproteins; Protein Kinases; Receptors, Cell Surface; Thrombin; Vasodilator Agents | 1992 |
Nitric oxide-induced blockade of NMDA receptors.
Topics: Animals; Calcium; Cyclic GMP; In Vitro Techniques; Mice; Molsidomine; N-Methylaspartate; N-Nitrosopyrrolidine; Nitric Oxide; Nitroso Compounds; Receptors, N-Methyl-D-Aspartate; Sodium Nitrite | 1992 |
Nitrovasodilators inhibit thrombin-induced platelet-activating factor synthesis in human endothelial cells.
Topics: Acetyltransferases; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Humans; Molsidomine; Nitroprusside; Platelet Activating Factor; Thrombin | 1992 |
L-cysteine augments the vasorelaxation induced by sodium nitrite and SIN-1 but not that due to acetylcholine.
Topics: Acetylcholine; Animals; Cyclic GMP; Cysteine; Drug Synergism; Endothelium, Vascular; In Vitro Techniques; Male; Mesenteric Arteries; Molsidomine; Nitric Oxide; Rats; Rats, Inbred Strains; Sodium Nitrite; Vasodilation | 1992 |
Pharmacological interaction experiments differentiate between glibenclamide-sensitive K+ channels and cyclic GMP as components of vasodilation by nicorandil.
Topics: Animals; Benzopyrans; Cattle; Coronary Vessels; Cromakalim; Cyclic GMP; Drug Interactions; Glyburide; Guanidines; In Vitro Techniques; Methylene Blue; Molsidomine; Muscle Relaxation; Niacinamide; Nicorandil; Nitroprusside; Pinacidil; Potassium Channels; Pyrroles; Sensitivity and Specificity; Vasodilator Agents | 1992 |
Inhibition of platelet arachidonic acid liberation by endothelium-derived relaxing factor (EDRF) as studied with sin-1, a nitric oxide generating drug. Evidence for calcium-dependent and calcium-independent mechanisms.
Topics: Arachidonic Acid; Blood Platelets; Calcium; Cyclic GMP; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Molsidomine; Nitric Oxide; Phospholipases A; Phospholipases A2; Thrombin | 1992 |
Modulation of the pharmacological actions of nitrovasodilators by methylene blue and pyocyanin.
Topics: Animals; Aorta; Cyclic GMP; Drug Interactions; In Vitro Techniques; Methylene Blue; Molsidomine; Nitric Oxide; Nitroglycerin; Nitroprusside; Penicillamine; Platelet Aggregation; Pyocyanine; Rabbits; S-Nitroso-N-Acetylpenicillamine; Sodium Nitrite; Vasodilator Agents | 1992 |
The molecular mechanism of central analgesia induced by morphine or carbachol and the L-arginine-nitric oxide-cGMP pathway.
Topics: Analgesia; Animals; Arginine; Brain; Carbachol; Cyclic GMP; Dinoprostone; Male; Molsidomine; Morphine; Nitric Oxide; Ornithine; Phthalazines; Rats; Rats, Wistar | 1992 |
Role of the L-arginine-NO pathway and of cyclic GMP in electrical field-induced noradrenaline release and vasoconstriction in the rat tail artery.
Topics: Animals; Arginine; Arteries; Atrial Natriuretic Factor; Cyclic GMP; Electric Stimulation; Endothelium, Vascular; In Vitro Techniques; Male; Methylene Blue; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Purinones; Rats; Tail; Vasoconstriction; Vasodilator Agents | 1992 |
Exogenous modification of nitrovasodilator-induced cyclic GMP formation in human lymphocytes.
Topics: Chromans; Cyclic GMP; Cysteine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylate Cyclase; Humans; L-Lactate Dehydrogenase; Lymphocytes; Molsidomine; Nitroprusside; Vasodilator Agents | 1992 |
Nitric oxide-releasing compounds inhibit Dictyostelium discoideum aggregation without altering cGMP production.
Topics: Animals; Antihypertensive Agents; Cyclic AMP; Cyclic GMP; Dictyostelium; Guanylate Cyclase; Molsidomine; Morphogenesis; Nitric Oxide; Nitroprusside; Vasodilator Agents | 1992 |
Inhibitors of calmodulin impair the constitutive but not the inducible nitric oxide synthase activity in the rat aorta.
Topics: Amino Acid Oxidoreductases; Animals; Aorta; Arginine; Calmodulin; Cyclic GMP; Drug Interactions; Endothelium, Vascular; Fendiline; Imidazoles; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Inbred Strains; Vasodilator Agents | 1992 |
The impairment of endothelium-dependent relaxations in reversed vein grafts is associated with a reduced production of cyclic guanosine monophosphate.
Topics: Acetylcholine; Animals; Carotid Arteries; Cyclic GMP; Endothelium, Vascular; Hemoglobins; In Vitro Techniques; Jugular Veins; Male; Molsidomine; Muscle Relaxation; Nitric Oxide; Rabbits; Vasodilator Agents; Veins | 1991 |
Comparative effects of some nitric oxide donors on cyclic GMP levels in rat cerebellar slices.
Topics: Animals; Cerebellum; Cyclic GMP; Hydroxylamine; Hydroxylamines; In Vitro Techniques; Molsidomine; Nitric Oxide; Nitroprusside; Penicillamine; Rats; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents | 1991 |
The molecular mechanism of action of peripheral morphine analgesia: stimulation of the cGMP system via nitric oxide release.
Topics: Analgesia; Animals; Arginine; Cyclic GMP; Male; Methylene Blue; Molsidomine; Morphine; Nitric Oxide; Ornithine; Phthalazines; Rats; Rats, Inbred Strains | 1991 |
Intercellular action of nitric oxide in adult rat cerebellar slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebellum; Cyclic GMP; Drug Interactions; Glutamates; Glutamic Acid; Hemoglobins; Hydroxylamine; Hydroxylamines; Ibotenic Acid; Kainic Acid; Molsidomine; N-Methylaspartate; Nitric Oxide; Nitroprusside; Penicillamine; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; S-Nitroso-N-Acetylpenicillamine | 1991 |
Cyclic GMP mediates SIN-1-induced inhibition of human polymorphonuclear leukocytes.
Topics: 1-Methyl-3-isobutylxanthine; Cyanides; Cyclic AMP; Cyclic GMP; Glucuronidase; Humans; In Vitro Techniques; Macrophage Activation; Methylene Blue; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitroglycerin; Nitroprusside; Nitrosamines; Vasodilator Agents | 1990 |
Effects of nitrovasodilators on platelet cyclic nucleotide levels in rabbit blood; role for cyclic AMP in synergistic inhibition of platelet function by SIN-1 and prostaglandin E1.
Topics: Alprostadil; Animals; Blood Platelets; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Epoprostenol; Male; Molsidomine; Nitric Oxide; Purinones; Rabbits; Serotonin; Vasodilator Agents | 1991 |
Reduced nitric oxide release causes nitrate tolerance in the intact coronary circulation.
Topics: Animals; Bradykinin; Cell Line; Coronary Vessels; Cyclic GMP; Drug Tolerance; Fibroblasts; Heart; Iloprost; Lung; Molsidomine; Myocardium; Nitrates; Nitric Oxide; Nitroglycerin; Rabbits; Rats; Vasodilator Agents | 1991 |
Modification of nitrovasodilator effects on vascular smooth muscle by exogenous GTP and guanosine.
Topics: Animals; Cyclic GMP; Guanosine; Guanosine Triphosphate; In Vitro Techniques; Male; Molsidomine; Muscle, Smooth, Vascular; Nitroglycerin; Rats; Rats, Inbred Strains; Sodium Nitrite; Vasodilation | 1991 |
Osteoclastic inhibition: an action of nitric oxide not mediated by cyclic GMP.
Topics: Animals; Animals, Newborn; Bone Resorption; Calcitonin; Calcium; Cell Membrane; Cells, Cultured; Cyclic GMP; Cytosol; Dibutyryl Cyclic GMP; Ionomycin; Kinetics; Molsidomine; Nitric Oxide; Osteoclasts; Rats; Rats, Inbred Strains; Vasodilator Agents | 1991 |
Nitrovasodilator-induced inhibition of LTB4 release from human PMN may be mediated by cyclic GMP.
Topics: Cyclic GMP; Humans; Leukotriene B4; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitroglycerin; Nitrosamines; Vasodilator Agents | 1990 |
Effect of molsidomine on ex vivo platelet aggregation and plasma guanosine 3':5'-cyclic monophosphate levels in healthy volunteers.
Topics: Adult; Cyclic GMP; Female; Humans; Male; Molsidomine; Platelet Aggregation; Platelet Aggregation Inhibitors; Prodrugs; Vasodilator Agents | 1990 |
Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP.
Topics: Adenosine; Adenylyl Cyclases; Alprostadil; Animals; Blood Platelets; Cyclic AMP; Cyclic GMP; Enzyme Activation; Ferricyanides; Hemoglobins; In Vitro Techniques; Kinetics; Molsidomine; Nitroprusside; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinolones; Rabbits; Radioimmunoassay; Vasodilator Agents | 1990 |
Inhibition of calcium influx in thrombin-stimulated platelets by SIN-1, an activator of soluble guanylate cyclase.
Topics: Biological Transport; Blood Platelets; Calcium; Cyclic GMP; Enzyme Activation; Fluorescence; Guanylate Cyclase; Humans; In Vitro Techniques; Molsidomine; Solubility; Thrombin; Vasodilator Agents | 1989 |
Inhibition of platelet activating factor-induced platelet aggregation by molsidomine, SIN-1, and nitrates in vitro and ex vivo.
Topics: Cyclic GMP; Enzyme Activation; In Vitro Techniques; Molsidomine; Nitrates; Nitric Oxide; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Vasodilator Agents | 1989 |
Interaction between SIN-1 and prostacyclin in inhibiting platelet aggregation.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; In Vitro Techniques; Molsidomine; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Vasodilator Agents | 1989 |
Molsidomine is a donor of EDRF.
Topics: Cyclic GMP; Drug Tolerance; Endothelium, Vascular; Enzyme Activation; Humans; Molsidomine; Nitric Oxide; Platelet Activation; Vasodilator Agents | 1989 |
Anti-ischemic actions of molsidomine by venous and large coronary dilatation in combination with antiplatelet effects.
Topics: Animals; Blood Platelets; Coronary Vessels; Cyclic GMP; Dogs; Dose-Response Relationship, Drug; Hemodynamics; Molsidomine; Platelet Aggregation Inhibitors; Vasodilator Agents | 1989 |
Generation of NO from molsidomine (SIN-1) in vitro and its relationship to changes in coronary vessel tone.
Topics: Animals; Cells, Cultured; Coronary Circulation; Coronary Vessels; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Iloprost; Molsidomine; Nitric Oxide; Nitroglycerin; Oxyhemoglobins; Rabbits; Vasodilator Agents | 1989 |
Tolerance and cross-tolerance between SIN-1 and nitric oxide in bovine coronary arteries.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; Enzyme Activation; In Vitro Techniques; Molsidomine; Nitric Oxide; Nitroglycerin; Nitroprusside; Vasodilator Agents | 1989 |
Effects of SIN-1 on isolated canine basilar arteries.
Topics: Animals; Basilar Artery; Cyclic GMP; Dogs; In Vitro Techniques; Molsidomine; Muscle Relaxation; Nitric Oxide; Nitroprusside; Vasodilator Agents | 1989 |
Modulation of the vasodilator action of SIN-1 by the endothelium.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Isoproterenol; Molsidomine; Nitric Oxide; Rabbits; Vasodilation; Vasodilator Agents | 1989 |
SIN-1 stimulates the production of cyclic GMP but not cyclic AMP in porcine aortic endothelial cells.
Topics: Animals; Aorta, Thoracic; Cells, Cultured; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Heme; Methylene Blue; Molsidomine; Rodentia; Vasodilator Agents | 1989 |
Effect of molsidomine and its metabolites on polymorphonuclear cell function and arachidonic acid metabolism.
Topics: Arachidonic Acid; Arachidonic Acids; Cyclic GMP; Glucuronidase; Humans; In Vitro Techniques; Molsidomine; Neutrophils; Nitrosamines; Vasodilator Agents | 1989 |
Clinical tolerance to nitroglycerin is due to impaired biotransformation of nitroglycerin and biological counterregulation, not to desensitization of guanylate cyclase.
Topics: Animals; Aorta; Cattle; Cells, Cultured; Cyclic GMP; Drug Tolerance; Endothelium, Vascular; Guanylate Cyclase; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Nitroprusside; Prodrugs; Rabbits; Vascular Resistance; Vasodilator Agents | 1989 |
Effect of a stimulant of guanylate cyclase, sin 1, on calcium movements and phospholipase C activation in thrombin-stimulated human platelets.
Topics: Blood Platelets; Calcium; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Humans; In Vitro Techniques; Molsidomine; Phosphatidic Acids; Serotonin; Thrombin; Type C Phospholipases | 1988 |
Stimulation of soluble coronary arterial guanylate cyclase by SIN-1.
Topics: Animals; Cations, Divalent; Cattle; Coronary Vessels; Cyclic GMP; Ferricyanides; Guanylate Cyclase; In Vitro Techniques; Methylene Blue; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Nitroprusside; Oxadiazoles; Sodium Nitrite; Sulfhydryl Compounds; Sydnones | 1986 |
Mode of action of nitrates with regard to vasodilatation and tolerance.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Nitrates; Nitroglycerin; Vasodilation | 1986 |
[SIN-1 interactions with the generation of cyclic nucleotides and arachidonate oxide metabolites in the uterine muscle].
Topics: Animals; Arachidonic Acids; Cyclic AMP; Cyclic GMP; Epoprostenol; Female; Guanylate Cyclase; Guinea Pigs; Molsidomine; Myometrium | 1987 |
Mechanism of vasodilation by molsidomine.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; In Vitro Techniques; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Oxadiazoles; Sydnones; Vasodilator Agents | 1985 |
Cyclic GMP as the mediator of molsidomine-induced vasodilatation.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Endothelium; In Vitro Techniques; Methylene Blue; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Oxadiazoles; Phosphodiesterase Inhibitors; Sydnones; Time Factors; Vasodilation | 1986 |
[Mechanism of the vasodilating effect and blood platelet- antiaggregating activity of molsidomine and SIN-1].
Topics: Animals; Cyclic GMP; Molsidomine; Muscle, Smooth, Vascular; Nitrates; Platelet Aggregation; Vasodilation | 1987 |
The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels.
Topics: Animals; Coronary Vessels; Cyclic AMP; Cyclic GMP; Dogs; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Molsidomine; Muscle Contraction; Muscle, Smooth, Vascular; Nitroglycerin; Oxadiazoles; Sydnones; Vasodilator Agents | 1983 |
A cellular mechanism for nitric oxide-mediated cholinergic control of mammalian heart rate.
Topics: 1-Methyl-3-isobutylxanthine; Aminoquinolines; Animals; Arginine; Carbachol; Cardiotonic Agents; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Enzyme Inhibitors; GTP-Binding Proteins; Guanylate Cyclase; Heart Rate; Isoproterenol; Methylene Blue; Molsidomine; Muscarinic Agonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Platelet Aggregation Inhibitors; Rabbits; Receptors, Cholinergic; Receptors, Muscarinic; Sinoatrial Node; Thionucleotides | 1995 |
Nitric oxide, superoxide and peroxynitrite: putative mediators of NMDA-induced cell death in cerebellar granule cells.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Catalase; Cell Death; Cells, Cultured; Cerebellum; Cyclic GMP; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Mice; Molsidomine; N-Methylaspartate; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Receptors, N-Methyl-D-Aspartate; Superoxide Dismutase; Superoxides; Xanthine Oxidase | 1993 |
Involvement of nitric oxide in the regulation of gonadotropin-releasing hormone release from the GT1-1 neuronal cell line.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cell Line; Cyclic GMP; Gonadotropin-Releasing Hormone; Mice; Mice, Transgenic; Molsidomine; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Norepinephrine; Sodium Nitrite | 1994 |
SIN-1 reverses attenuation of hypercapnic cerebrovasodilation by nitric oxide synthase inhibitors.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cerebrovascular Circulation; Cyclic GMP; Hypercapnia; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Papaverine; Rats; Rats, Sprague-Dawley; Vasodilation | 1994 |
Nitric oxide inhibits bafilomycin-sensitive H(+)-ATPase activity in rat cortical collecting duct.
Topics: Amino Acid Oxidoreductases; Animals; Anti-Bacterial Agents; Arginine; Cyclic GMP; Enzyme Induction; Ethylmaleimide; Female; In Vitro Techniques; Interferon-gamma; Kidney Tubules, Collecting; Kinetics; Lipopolysaccharides; Macrolides; Macrophages; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Proton-Translocating ATPases; Rats; Rats, Sprague-Dawley; Vacuoles | 1994 |
Nitric oxide and cyclic guanosine 3',5'-monophosphate do not alter neuropeptide release from rat sensory neurons grown in culture.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Cyclic GMP; Molsidomine; Neurons, Afferent; Neuropeptides; Nitric Oxide; Nitroprusside; Rats; Rats, Sprague-Dawley; Substance P | 1994 |
Influence of nitric oxide synthase inhibition, nitric oxide and hydroperoxide on insulin release induced by various secretagogues.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Oxidoreductases; Animals; Arginine; Colforsin; Cyclic AMP; Cyclic GMP; Female; Glucose; Hydrogen Peroxide; Hydroxylamine; Hydroxylamines; In Vitro Techniques; Insulin; Islets of Langerhans; Mice; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peroxides; Reactive Oxygen Species; tert-Butylhydroperoxide; Vasodilator Agents | 1995 |
Pyrrolidine dithiocarbamate selectively prevents the expression of the inducible nitric oxide synthase in the rat aorta.
Topics: Acetylcholine; Amino Acid Oxidoreductases; Analysis of Variance; Animals; Antioxidants; Aorta, Thoracic; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Induction; Interleukin-1; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; NADPH Dehydrogenase; Nitric Oxide Synthase; Pyrrolidines; Radioimmunoassay; Rats; Rats, Wistar; Thiocarbamates; Vasodilator Agents | 1994 |
The role of free radicals in NMDA-dependent neurotoxicity.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Calcium; Cells, Cultured; Cerebellar Cortex; Cyclic GMP; Electron Spin Resonance Spectroscopy; Enzyme Activation; Epilepsy; Feedback; Free Radicals; Glutamic Acid; Guanylate Cyclase; Kindling, Neurologic; Mice; Molsidomine; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Receptors, N-Methyl-D-Aspartate | 1994 |
Secretion of cyclic GMP by cultured epithelial and fibroblast cell lines in response to nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cyclic AMP; Cyclic GMP; Epithelium; Fibroblasts; Guanylate Cyclase; Molsidomine; Nitric Oxide; Oxyhemoglobins; Probenecid; Swine | 1995 |
Role of cyclic nucleotides and nitric oxide in blood mononuclear cell IgE production stimulated by IL-4.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Arginine; B-Lymphocytes; Cholera Toxin; Cyclic AMP; Cyclic GMP; Drug Synergism; Epinephrine; Gene Expression Regulation; Humans; Immunoglobulin E; Interleukin-4; Leukocytes, Mononuclear; Molsidomine; Nitric Oxide; omega-N-Methylarginine; Receptors, IgE; Recombinant Fusion Proteins | 1995 |
Synergistic phosphorylation of platelet rap1B by SIN-1 and iloprost.
Topics: Autoradiography; Blood Platelets; Blotting, Western; Cells, Cultured; Cyclic AMP; Cyclic GMP; Drug Synergism; GTP-Binding Proteins; Humans; Iloprost; Molsidomine; Nitric Oxide; Phosphorylation; Platelet Aggregation Inhibitors; rap GTP-Binding Proteins | 1995 |
Cyclic guanosine 3',5'-monophosphate mediates 3-morpholinosydnonimine-induced inhibition of human natural killer cells.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Cyclic GMP; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Humans; Interferon-gamma; Killer Cells, Natural; Methylene Blue; Molsidomine; Nitric Oxide; Tumor Cells, Cultured | 1995 |
Synergistic interaction of adenylate cyclase activators and nitric oxide donor SIN-1 on platelet cyclic AMP.
Topics: Adenylyl Cyclases; Alprostadil; Blood Platelets; Cyclic AMP; Cyclic GMP; Drug Synergism; Enzyme Activation; Guanylate Cyclase; Humans; Iloprost; In Vitro Techniques; Molsidomine; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors | 1995 |
The effect of NO-donors in bovine and rat pineal cells: stimulation of cGMP and cGMP-independent inhibition of melatonin synthesis.
Topics: Animals; Cattle; Cells, Cultured; Cyclic GMP; Isoproterenol; Melatonin; Molsidomine; Nitric Oxide; Nitroprusside; Pineal Gland; Rats; Stimulation, Chemical | 1995 |
Nitric oxide inhibition of human sperm motility.
Topics: Cyclic GMP; Hemoglobins; Humans; Male; Molsidomine; Nitric Oxide; Nitroprusside; Reactive Oxygen Species; Sperm Motility | 1995 |
Evidence for the involvement of cGMP in neural bronchodilator responses in humal trachea.
Topics: Adenosine Monophosphate; Adolescent; Adult; Arginine; Bronchoconstriction; Child; Chymotrypsin; Cyclic GMP; Electric Conductivity; Epithelium; Female; Humans; Male; Methylene Blue; Middle Aged; Molsidomine; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Tetrodotoxin; Time Factors; Trachea; Vasoactive Intestinal Peptide; Vasodilator Agents | 1995 |
Potentiation of the hyporeactivity induced by in vivo endothelial injury in the rat carotid artery by chronic treatment with fish oil.
Topics: Analysis of Variance; Animals; Arginine; Blood Pressure; Body Weight; Carotid Arteries; Carotid Artery Injuries; Catheterization; Cyclic GMP; Endothelium, Vascular; Fatty Acids; Fish Oils; Indomethacin; Isometric Contraction; Male; Methylene Blue; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Phenylephrine; Rats; Rats, Wistar; Superoxide Dismutase; Vascular Resistance; Vasodilator Agents | 1995 |
Interleukin-1 beta effects on cyclic GMP and cyclic AMP in cultured rat islets of Langerhans-arginine-dependence and relationship to insulin secretion.
Topics: 1-Methyl-3-isobutylxanthine; Aminoquinolines; Animals; Antihypertensive Agents; Arginine; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Female; Insulin; Insulin Secretion; Interleukin-1; Islets of Langerhans; Kinetics; Molsidomine; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley | 1993 |
Activation of endothelial guanylate cyclase inhibits cellular reactivity.
Topics: Arachidonic Acid; Cell Adhesion; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Epoprostenol; Guanylate Cyclase; Humans; Molsidomine; Nitric Oxide; Nitroprusside; Oxadiazoles; Platelet Activating Factor; Thrombin; Umbilical Veins | 1995 |
Effects of NO-donors, SIN-1 and GEA 3175 on prostacyclin and cGMP synthesis in cultured rat endothelial cells.
Topics: Animals; Arginine; Calcimycin; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Epoprostenol; Female; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Triazoles | 1995 |
Nitrogen monoxide decreases iron uptake from transferrin but does not mobilise iron from prelabelled neoplastic cells.
Topics: Animals; Cell Line; Cyclic GMP; Humans; Iodine Radioisotopes; Iron; Iron Radioisotopes; Melanoma; Mice; Molsidomine; Nitric Oxide; Nitrites; Nitroprusside; Thymidine; Transferrin | 1995 |
Effects of Trolox C and SIN-1 on arachidonic acid metabolism and on cyclic GMP formation in leukocytes.
Topics: Antioxidants; Arachidonic Acid; Calcimycin; Centrifugation, Density Gradient; Chromans; Cyclic GMP; Dibutyryl Cyclic GMP; Dinoprostone; Dose-Response Relationship, Drug; Guanylate Cyclase; Humans; Leukotriene B4; Molsidomine; Neutrophils; Radioimmunoassay; Vasodilator Agents; Vitamin E | 1994 |
Selective regulation of dendritic MAP2 mRNA levels in hippocampal granule cells by nitric oxide.
Topics: Animals; Base Sequence; Cyclic GMP; Cytoskeleton; Dendrites; Gene Expression Regulation; Hippocampus; Male; Microtubule-Associated Proteins; Molecular Sequence Data; Molsidomine; N-Methylaspartate; Nerve Tissue Proteins; Nitric Oxide; Nitroprusside; Rats; Rats, Wistar; Receptors, Glutamate; RNA, Messenger | 1994 |
KCa channel antagonists reduce NO donor-mediated relaxation of vascular and tracheal smooth muscle.
Topics: Animals; Calcium; Cyclic GMP; Guinea Pigs; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Nitric Oxide; Penicillamine; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Trachea | 1995 |
Nitric oxide regulates the calcium current in isolated human atrial myocytes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Anura; Calcium Channels; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Female; Heart; Heart Atria; Humans; Isoproterenol; Kinetics; Male; Membrane Potentials; Middle Aged; Milrinone; Molsidomine; Nitric Oxide; Patch-Clamp Techniques; Pyridones; Time Factors; Vasodilator Agents | 1995 |
Interaction between cGMP-dependent dilators and autoregulation in rat preglomerular vasculature.
Topics: Animals; Atrial Natriuretic Factor; Cyclic GMP; Dose-Response Relationship, Drug; Homeostasis; Kidney Glomerulus; Male; Molsidomine; Nitroprusside; Rats; Rats, Sprague-Dawley; Renal Circulation; Vasodilator Agents | 1995 |
cGMP mediates the desensitization to bradykinin in isolated canine coronary arteries.
Topics: Animals; Arginine; Arteries; Bradykinin; Coronary Vessels; Cyclic GMP; Dogs; Drug Resistance; In Vitro Techniques; Methylene Blue; Molsidomine; Nitroarginine; Oxyhemoglobins; Potassium; Vasodilation; Vasodilator Agents | 1995 |
Nitric oxide blocks bile canalicular contraction by inhibiting inositol trisphosphate-dependent calcium mobilization.
Topics: Animals; Bile Canaliculi; Calcium; Calcium Channel Blockers; Cyclic GMP; Inositol 1,4,5-Trisphosphate; Male; Molsidomine; Muscle Contraction; Nitric Oxide; Nitroprusside; Rats; Signal Transduction; Vasodilator Agents | 1995 |
Failure of nitric oxide donors to alter arrhythmias induced by acute myocardial ischaemia or reperfusion in anaesthetized rats.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cyclic AMP; Cyclic GMP; Hemodynamics; Isosorbide Dinitrate; Male; Molsidomine; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitroprusside; Rats; Rats, Wistar; Vasodilator Agents | 1995 |
Effects of cGMP on calcium handling in ATP-stimulated rat resistance arteries.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium-Transporting ATPases; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Male; Mesenteric Arteries; Molsidomine; Myosins; Nitrendipine; Nitroprusside; Phosphorylation; Rats; Rats, Wistar; Terpenes; Thapsigargin; Vascular Resistance; Vasoconstriction | 1995 |
Nitric oxide regulates cardiac Ca2+ current. Involvement of cGMP-inhibited and cGMP-stimulated phosphodiesterases through guanylyl cyclase activation.
Topics: Animals; Calcium Channels; Colforsin; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Heart Ventricles; In Vitro Techniques; Isoproterenol; Molsidomine; Nitric Oxide; Phosphoric Diester Hydrolases; Rana esculenta | 1993 |
Nitric oxide has no chronotropic effect in right atria isolated from rat heart.
Topics: Acetylcholine; Aminoquinolines; Animals; Aorta, Thoracic; Arginine; Cyclic GMP; Guanylate Cyclase; Heart Atria; Heart Rate; In Vitro Techniques; Male; Methylene Blue; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroarginine; Norepinephrine; Parasympathetic Nervous System; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Vasodilator Agents | 1994 |
The effect of nitric oxide donors on insulin secretion, cyclic GMP and cyclic AMP in rat islets of Langerhans and the insulin-secreting cell lines HIT-T15 and RINm5F.
Topics: Animals; Cell Line; Cyclic AMP; Cyclic GMP; Drug Interactions; Female; Glutathione; Hydroxylamine; Hydroxylamines; Insulin; Insulin Secretion; Islets of Langerhans; Molsidomine; Nitric Oxide; Nitroso Compounds; Penicillamine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione | 1994 |
Smooth muscle tone regulation in rabbit cavernosal and spongiosal tissue by cyclic AMP- and cyclic GMP-dependent mechanisms.
Topics: Animals; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Molsidomine; Muscle Tonus; Muscle, Smooth; Penis; Phenylephrine; Phosphodiesterase Inhibitors; Rabbits | 1994 |
Nitric oxide alters proenkephalin and prodynorphin gene expression in hippocampal granule cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Base Sequence; Cyclic GMP; Dendrites; Enkephalins; Gene Expression Regulation; Hippocampus; In Situ Hybridization; Molecular Sequence Data; Molsidomine; N-Methylaspartate; Nitric Oxide; Nitroprusside; Protein Precursors; Rats; RNA, Messenger; Vasodilator Agents | 1994 |
An ADP-ribosyltransferase as a potential target for nitric oxide action in hippocampal long-term potentiation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cyclic GMP; Dibutyryl Cyclic GMP; Evoked Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Molsidomine; N-Methylaspartate; NAD; Niacinamide; Nitric Oxide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
Regulation of blood-brain barrier endothelial cells by nitric oxide.
Topics: Animals; Blood-Brain Barrier; Brain; Cell Membrane; Cells, Cultured; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Guanosine 5'-O-(3-Thiotriphosphate); Male; Models, Cardiovascular; Molsidomine; Nitric Oxide; Nitroprusside; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Tetraethylammonium Compounds; Vasodilator Agents | 1994 |
Altered nitric oxide production and exogenous nitric oxide do not affect the proliferation of rat mesangial cells.
Topics: Animals; Arginine; Cell Division; Cells, Cultured; Cyclic GMP; Glomerular Mesangium; Interleukin-1; Lipopolysaccharides; Molsidomine; Nitric Oxide; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley | 1994 |
Effects of nitric oxide donors in vitro on the arachidonic acid-induced platelet release reaction and platelet cyclic GMP concentration in pre-eclampsia.
Topics: Adolescent; Adult; Blood Platelets; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Female; Humans; Molsidomine; Nitric Oxide; Nitroprusside; Platelet Activation; Pre-Eclampsia; Pregnancy | 1994 |
Nitric oxide decreases in vitro phagocytosis of photoreceptor outer segments by bovine retinal pigmented epithelial cells.
Topics: Animals; Cattle; Cells, Cultured; Cyclic GMP; Interferon-gamma; Lipopolysaccharides; Molsidomine; Nitric Oxide; Phagocytosis; Pigment Epithelium of Eye; Rod Cell Outer Segment | 1994 |
Neuronal growth cone collapse and inhibition of protein fatty acylation by nitric oxide.
Topics: Acylation; Animals; Cells, Cultured; Cyclic GMP; Dibutyryl Cyclic GMP; Ganglia, Spinal; Hemoglobins; Molsidomine; Nerve Crush; Nerve Tissue Proteins; Neurites; Neurons; Nitric Oxide; Palmitic Acid; Palmitic Acids; PC12 Cells; Rats; Sciatic Nerve; Time Factors; Vasodilator Agents | 1993 |
Direct inhibition of platelet function by organic nitrates via nitric oxide formation.
Topics: Adenosine Triphosphate; Animals; Anisotropy; Blood Platelets; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Esters; Fibroblasts; Humans; Lung; Molsidomine; Nitrates; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Thromboxanes | 1993 |
Nitric oxide-induced microvascular permeability alterations: a regulatory role for cGMP.
Topics: Animals; Arginine; Atrial Natriuretic Factor; Capillary Permeability; Cats; Cyclic GMP; Intestines; Methylene Blue; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Regional Blood Flow | 1993 |
Vascular relaxation and cyclic guanosine monophosphate in a rat model of high output heart failure.
Topics: Acetylcholine; Animals; Atrial Natriuretic Factor; Calcimycin; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Failure; Male; Molsidomine; Nitric Oxide; Rats; Rats, Wistar; Vasodilation | 1993 |
Changes in cytosolic cGMP and calcium in airway smooth muscle relaxed by 3-morpholinosydnonimine.
Topics: Animals; Calcium; Cyclic AMP; Cyclic GMP; Cytosol; Dogs; Female; In Vitro Techniques; Male; Methylene Blue; Molsidomine; Muscle Relaxation; Muscle, Smooth; Osmolar Concentration; Trachea | 1994 |
Enzymic and nonenzymic release of NO accounts for the vasodilator activity of the metabolites of CAS 936, a novel long-acting sydnonimine derivative.
Topics: Animals; Blood Vessels; Cattle; Cyclic GMP; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; Female; In Vitro Techniques; Male; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Nitroso Compounds; Piperidines; Rabbits; Swine; Sydnones; Vasodilator Agents | 1993 |
Endothelial L-arginine pathway and relaxations to vasopressin in canine basilar artery.
Topics: Animals; Arginine; Basilar Artery; Cyclic GMP; Dogs; Endothelium, Vascular; In Vitro Techniques; Molsidomine; Nitric Oxide; Nitroarginine; Vasodilation; Vasopressins | 1993 |
Nitric oxide donors reduce the rise in reperfusion-induced intestinal mucosal permeability.
Topics: Animals; Cats; Cyclic GMP; Intestinal Mucosa; Intestines; Ischemia; Molsidomine; Nitric Oxide; Nitroprusside; Permeability; Regional Blood Flow; Reperfusion Injury; Sydnones | 1993 |
Inhibition by nitric oxide-donors of human polymorphonuclear leucocyte functions.
Topics: Cell Degranulation; Chemotaxis, Leukocyte; Cyclic AMP; Cyclic GMP; Glucuronidase; Humans; In Vitro Techniques; Leukotriene B4; Luminescent Measurements; Molsidomine; Neutrophils; Nitric Oxide; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Superoxides; Triazoles | 1993 |
Liberators of NO exert a dual effect on renin secretion from isolated mouse renal juxtaglomerular cells.
Topics: Animals; Cell Separation; Cyclic AMP; Cyclic GMP; Juxtaglomerular Apparatus; Mice; Molsidomine; Nitric Oxide; Nitroprusside; Renin | 1993 |
Actions of 3-morpholinosydnonimin (SIN-1) on rabbit isolated penile erectile tissue.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic GMP; Male; Molsidomine; Nitric Oxide; Nitroprusside; Penile Erection; Penis; Purinones; Rabbits; Vasodilator Agents | 1993 |
The effect of nitric oxide-donating vasodilators on monocyte chemotaxis and intracellular cGMP concentrations in vitro.
Topics: Cell Migration Inhibition; Chemotaxis, Leukocyte; Cyclic GMP; Humans; Isosorbide Dinitrate; Molsidomine; Monocytes; Nitroglycerin; Nitroprusside; Vasodilator Agents | 1993 |
Interaction of antiplatelet drugs in vitro: aspirin, iloprost, and the nitric oxide donors SIN-1 and sodium nitroprusside.
Topics: Adenosine Triphosphate; Aspirin; Blood Platelets; Cyclic AMP; Cyclic GMP; Drug Interactions; Humans; Iloprost; In Vitro Techniques; Iodine Radioisotopes; Molsidomine; Nitric Oxide; Nitroprusside; Phosphorylation; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors | 1995 |
Nitric oxide donors induce extrusion of cyclic GMP from isolated human blood platelets by a mechanism which may be modulated by prostaglandins.
Topics: 1-Methyl-3-isobutylxanthine; Blood Platelets; Cells, Cultured; Culture Media; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Space; Guanylate Cyclase; Humans; Ion Transport; Molsidomine; Nitric Oxide; Ouabain; Penicillamine; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Probenecid; Prostaglandin D2; Prostaglandins; Prostaglandins A; Purinones; S-Nitroso-N-Acetylpenicillamine; Sodium-Potassium-Exchanging ATPase; Time Factors; Triazoles | 1995 |
Nitric oxide synthase (NOS3)-mediated cholinergic modulation of Ca2+ current in adult rabbit atrioventricular nodal cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Action Potentials; Animals; Arginine; Atrioventricular Node; Calcium Channels; Carbachol; Cyclic GMP; Immunohistochemistry; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rabbits; Receptors, Muscarinic | 1996 |
Myocardial contractile response to nitric oxide and cGMP.
Topics: Animals; Cats; Cyclic GMP; Endothelium, Vascular; In Vitro Techniques; Molsidomine; Myocardial Contraction; Nitric Oxide; Nitroprusside; Penicillamine; Purinones; S-Nitroso-N-Acetylpenicillamine | 1996 |
Rat duodenum nitrergic-induced relaxations are cGMP-independent and apamin-sensitive.
Topics: 4-Aminopyridine; Animals; Apamin; Cyclic GMP; Cystamine; Duodenum; Hydroxylamines; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Nitric Oxide; Rats; Rats, Wistar; Tetraethylammonium Compounds | 1995 |
Effects of KRN2391, a novel vasodilator acting as a nitrate and a K+ channel opener, on the rabbit lower urinary tract.
Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Electrophysiology; Female; Hypoglycemic Agents; Molsidomine; Muscle Relaxation; Muscle, Smooth; Pyridines; Pyrroles; Rabbits; Urethra; Vasodilator Agents | 1995 |
Increased guanylate cyclase activity is associated with an increase in cyclic guanosine 3',5'-monophosphate in left ventricular hypertrophy.
Topics: Animals; Arginine; Cyclic GMP; Dogs; Female; Guanylate Cyclase; Hypertrophy, Left Ventricular; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Oxygen Consumption | 1996 |
Activation of a NO-cyclic GMP system by NO donors potentiates beta-endorphin-induced antinociception in the mouse.
Topics: Analgesics; Analgesics, Opioid; Animals; beta-Endorphin; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Molsidomine; Nitric Oxide; Nitroprusside; Pain Measurement; Rats | 1995 |
Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS.
Topics: Animals; Base Sequence; Blood Platelets; Cattle; Cell Adhesion Molecules; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Humans; In Vitro Techniques; Microfilament Proteins; Molecular Sequence Data; Molsidomine; Muscle, Smooth, Vascular; Norepinephrine; Phosphoproteins; Phosphorylation; Rats; Stereoisomerism; Thionucleotides; Vasoconstriction; Vasodilator Agents | 1995 |
Nitric oxide donors suppress erythropoietin production in vitro.
Topics: Carcinoma, Hepatocellular; Cyclic GMP; Cytokines; Erythropoietin; Humans; Hydrogen Peroxide; Liver Neoplasms; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Penicillamine; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine; Tumor Cells, Cultured | 1996 |
Regional specific effects of nitric oxide donors and cGMP on the electrical activity of neurons in the rat spinal cord.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Histocytochemistry; Male; Molsidomine; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Organ Culture Techniques; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Spinal Cord; Vasodilator Agents | 1996 |
Inhibition of beta- but not alpha 1-mediated adrenergic responses in isolated hearts and cardiomyocytes by nitric oxide and 8-bromo cyclic GMP.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Calcium; Cell Size; Cells, Cultured; Cyclic GMP; Isoproterenol; Male; Molsidomine; Myocardial Contraction; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Penicillamine; Perfusion; Phenylephrine; Propranolol; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Stimulation, Chemical; Vasodilator Agents | 1996 |
Regulation of VIP release from rat enteric nerve terminals: evidence for a stimulatory effect of NO.
Topics: Animals; Arginine; Calcium; Cell Fractionation; Cyclic GMP; Intestine, Small; Membrane Potentials; Molsidomine; NADPH Dehydrogenase; Nerve Endings; Nitric Oxide; Nitroprusside; Protein Kinase C; Rats; Rats, Wistar; Synaptosomes; Tetradecanoylphorbol Acetate; Vasoactive Intestinal Peptide | 1996 |
Nitric oxide inhibits intracellular adhesion molecule-1 expression in rat mesangial cells.
Topics: Animals; Antibodies, Monoclonal; Cells, Cultured; Cyclic GMP; Enzyme-Linked Immunosorbent Assay; Free Radical Scavengers; Glomerular Mesangium; Intercellular Adhesion Molecule-1; Interleukin-1; Male; Molsidomine; Nitric Oxide; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1996 |
Effect of intracerebroventricular and intravenous administration of nitric oxide donors on blood pressure and heart rate in anaesthetized rats.
Topics: Animals; Blood Pressure; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart Rate; Injections, Intravenous; Injections, Intraventricular; Male; Molsidomine; Nitric Oxide; Nitroprusside; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Triazoles | 1996 |
Evidence that potassium channels make a major contribution to SIN-1-evoked relaxation of rat isolated mesenteric artery.
Topics: Animals; Cyclic GMP; Endothelium, Vascular; In Vitro Techniques; Male; Mesenteric Arteries; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Rats; Rats, Wistar; Superoxide Dismutase; Vasodilator Agents | 1996 |
Nitric oxide involvement in Hydra vulgaris very primitive olfactory-like system.
Topics: Animals; Calcium; Calmodulin; Cyclic GMP; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Feeding Behavior; Hydra; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitroprusside; Olfactory Pathways | 1997 |
In-vitro bronchorelaxing effects of novel nitric oxide donors GEA 3268 and GEA 5145 in guinea-pigs and rats.
Topics: Albuterol; Animals; Bronchodilator Agents; Cyclic GMP; Female; Guinea Pigs; In Vitro Techniques; Male; Mesenteric Arteries; Molsidomine; Nitric Oxide; Nitroprusside; Rats; Rats, Wistar; Triazoles | 1996 |
A possible role for nitric oxide in the regulation of human ureteral smooth muscle tone in vitro.
Topics: Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Humans; Immunohistochemistry; In Vitro Techniques; Molsidomine; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Nitric Oxide; Potassium Chloride; Thionucleotides; Ureter | 1996 |
Nitric oxide-releasing agents and cGMP analogues inhibit murine erythroleukemia cell differentiation and suppress erythroid-specific gene expression: correlation with decreased DNA binding of NF-E2 and altered c-myb mRNA expression.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Animals; Base Sequence; Cell Differentiation; Cell Line; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Cyclic GMP; Dimethyl Sulfoxide; DNA-Binding Proteins; Erythroid-Specific DNA-Binding Factors; GATA1 Transcription Factor; Gene Expression Regulation, Neoplastic; Globins; Leukemia, Erythroblastic, Acute; Mice; Molecular Sequence Data; Molsidomine; NF-E2 Transcription Factor; NF-E2 Transcription Factor, p45 Subunit; Nitric Oxide; Nuclear Proteins; Oligonucleotide Probes; Oncogenes; Phosphodiesterase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myb; Purinones; Recombinant Proteins; RNA, Messenger; Thionucleotides; Trans-Activators; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1995 |
Effects of sodium nitroprusside in the rat cortical collecting duct are independent of the NO pathway.
Topics: Animals; Arginine Vasopressin; Cyclic GMP; Enzyme Inhibitors; Female; In Vitro Techniques; Kidney Cortex; Kidney Tubules, Collecting; Membrane Potentials; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Perfusion; Potassium Channels; Rats; Rats, Wistar | 1997 |
Dual role of cGMP in modulation of macromolecule permeability of aortic endothelial cells.
Topics: Animals; Aorta; Atrial Natriuretic Factor; Calcium; Capillary Permeability; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Extracellular Space; Guanylate Cyclase; Macromolecular Substances; Molsidomine; Serum Albumin; Stimulation, Chemical; Swine | 1997 |
Nitric oxide attenuates adhesion molecule expression in human endothelial cells.
Topics: Cell Adhesion; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Interleukin-1; Molsidomine; Nitric Oxide; RNA, Messenger; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 1996 |
Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery.
Topics: Animals; Basilar Artery; Calcimycin; Chelating Agents; Cyclic GMP; Dogs; Egtazic Acid; Enzyme Inhibitors; Gene Expression; Immunohistochemistry; In Vitro Techniques; Ionophores; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Recombinant Proteins; Transfection; Uridine Triphosphate; Vasodilation; Vasodilator Agents | 1997 |
Negative metabolic effects of cyclic GMP are altered in renal hypertension induced cardiac hypertrophy.
Topics: Animals; Blood Gas Analysis; Cardiomegaly; Coronary Circulation; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Hemodynamics; Hypertension, Renovascular; Molsidomine; Myocardium; Oxygen; Rabbits | 1997 |
Nitric oxide induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle cells.
Topics: Animals; Carbon Monoxide; Cells, Cultured; Cyclic GMP; Cycloheximide; Cytokines; Dactinomycin; Enzyme Inhibitors; Gene Expression Regulation; Heme Oxygenase (Decyclizing); Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Penicillamine; Rats; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Time Factors; Transcription, Genetic | 1997 |
Interference of carboxy-PTIO with nitric oxide- and peroxynitrite-mediated reactions.
Topics: Animals; Benzoates; Cattle; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Free Radical Scavengers; Imidazoles; Kinetics; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Serum Albumin, Bovine; Swine; Tyrosine | 1997 |
Obligatory role of NO in glutamate-dependent hyperemia evoked from cerebellar parallel fibers.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cerebellum; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Glutamic Acid; Hyperemia; Indazoles; Male; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxygen; Papaverine; Partial Pressure; Penicillamine; Rats; Rats, Sprague-Dawley; Regional Blood Flow; S-Nitroso-N-Acetylpenicillamine; Vasodilation | 1997 |
3-Morpholino-sydnonimine-induced suppression of human neutrophil degranulation is not mediated by cyclic GMP, nitric oxide or peroxynitrite: inhibition of the increase in intracellular free calcium concentration by N-morpholino-iminoacetonitrile, a metabo
Topics: Acetonitriles; Calcium; Cell Degranulation; Cyclic GMP; Humans; Molsidomine; Morpholines; Neutrophils; Nitrates; Nitric Oxide | 1997 |
Role of potassium channels in relaxations of canine middle cerebral arteries induced by nitric oxide donors.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; 4-Aminopyridine; Animals; Barium Compounds; Cerebral Arteries; Charybdotoxin; Chlorides; Cyclic GMP; Diltiazem; Dogs; Glyburide; In Vitro Techniques; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Potassium Channels; Purinones; Vasodilation; Vasodilator Agents | 1997 |
Opposite effects of nitric oxide on identified inhibitory and excitatory cholinergic synapses of Aplysia californica.
Topics: Acetylcholine; Action Potentials; Animals; Aplysia; Arginine; Calcium Channels; Cholinergic Agonists; Cholinergic Antagonists; Cyclic GMP; Ganglia, Invertebrate; Ganglia, Parasympathetic; Guanylate Cyclase; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Potassium Channels; Synapses; Synaptic Transmission | 1996 |
Subarachnoid hemorrhage impairs cerebral blood flow response to nitric oxide but not to cyclic GMP in large cerebral arteries.
Topics: Animals; Brain; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circulation; Cyclic GMP; Injections, Intra-Articular; Male; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Papaverine; Phenylephrine; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Subarachnoid Hemorrhage; Time Factors; Vasodilator Agents | 1997 |
Nitric oxide can increase heart rate by stimulating the hyperpolarization-activated inward current, I(f).
Topics: Animals; Cyclic GMP; Data Interpretation, Statistical; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Ion Channels; Male; Molsidomine; Nitric Oxide; Nitroprusside; Rabbits; Sinoatrial Node; Superoxide Dismutase; Time Factors; Vasodilator Agents | 1997 |
Nitric oxide donors inhibit spontaneous depolarizations by L-type Ca2+ currents in alveolar epithelial cells.
Topics: Aminoquinolines; Animals; Calcium Channels; Calcium Channels, L-Type; Cell Line; Cyclic GMP; Enzyme Inhibitors; Epithelium; Guanylate Cyclase; Kinetics; Membrane Potentials; Microelectrodes; Molsidomine; Nitroprusside; Penicillamine; Pulmonary Alveoli; Rats; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Strontium; Time Factors | 1997 |
Heterogeneity in the vasorelaxing effect of nicorandil on dog epicardial coronary arteries: comparison with other NO donors.
Topics: Animals; Atrial Natriuretic Factor; Benzopyrans; Coronary Vessels; Cromakalim; Cyclic GMP; Dogs; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitric Oxide; Nitroglycerin; Nitroprusside; Oxyhemoglobins; Pyrroles; Vasodilator Agents | 1997 |
Nitric oxide attenuates platelet-activating factor priming for elastase release in human neutrophils via a cyclic guanosine monophosphate-dependent pathway.
Topics: Adult; Analysis of Variance; Cyclic GMP; Dibutyryl Cyclic GMP; Humans; In Vitro Techniques; Kinetics; Leukocyte Elastase; Models, Biological; Molsidomine; Neutrophils; Nitric Oxide; Platelet Activating Factor; Signal Transduction; Substrate Specificity | 1997 |
The beta2 subunit inhibits stimulation of the alpha1/beta1 form of soluble guanylyl cyclase by nitric oxide. Potential relevance to regulation of blood pressure.
Topics: Animals; Blood Pressure; Blotting, Northern; Blotting, Western; Cell Line; COS Cells; Cyclic GMP; Guanylate Cyclase; Kidney; Male; Molsidomine; Muscle, Smooth; Nitric Oxide; Rats; Rats, Inbred Strains; Recombinant Fusion Proteins; RNA, Messenger; Transfection; Vasodilator Agents | 1997 |
Dysfunction of nitric oxide induces protein kinase C activation resulting in vasospasm after subarachnoid hemorrhage.
Topics: Animals; Basilar Artery; Cyclic GMP; Dogs; Enzyme Activation; Enzyme Inhibitors; Female; Immunoenzyme Techniques; Ischemic Attack, Transient; Male; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Protein Kinase C; Reference Values; Subarachnoid Hemorrhage | 1997 |
Effects of nitric oxide on chemotaxis and endotoxin-induced interleukin-8 production in human neutrophils.
Topics: Acetylcysteine; Cells, Cultured; Chemotaxis; Complement C5a; Cyclic GMP; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Ferricyanides; Glutathione; Humans; Interleukin-8; Leukotriene B4; Lipopolysaccharides; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Nitroso Compounds; omega-N-Methylarginine; RNA, Messenger; S-Nitrosoglutathione; Up-Regulation | 1998 |
Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation.
Topics: Animals; Calcium; Cyclic GMP; Cysteine; Dithiothreitol; Dogs; Electric Conductivity; Ethylmaleimide; Glutathione; Liposomes; Mercaptoethanol; Molsidomine; Myocardium; Nitric Oxide; Nitrosation; Nitroso Compounds; Oxidation-Reduction; Proteolipids; Ryanodine Receptor Calcium Release Channel; S-Nitrosoglutathione; S-Nitrosothiols; Sulfhydryl Compounds | 1998 |
The nitric oxide donor SIN-1 protects endothelial cells from tumor necrosis factor-alpha-mediated cytotoxicity: possible role for cyclic GMP and heme oxygenase.
Topics: Acetonitriles; Animals; Cattle; Cells, Cultured; Cyclic GMP; Drug Interactions; Endothelium, Vascular; Heme Oxygenase (Decyclizing); Molsidomine; Morpholines; Nitric Oxide; Reactive Oxygen Species; Tumor Necrosis Factor-alpha; Vasodilator Agents | 1997 |
Nitric oxide and cyclic nucleotides participate in the relaxation of diclofenac on rat uterine smooth muscle.
Topics: Adenylyl Cyclases; Animals; Cyclic GMP; Cyclooxygenase Inhibitors; Diclofenac; Drug Interactions; Enzyme Inhibitors; Female; GTP-Binding Proteins; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Nucleotides, Cyclic; omega-N-Methylarginine; Oxadiazoles; Pertussis Toxin; Quinoxalines; Rats; Rats, Wistar; Sensitivity and Specificity; Sulfonamides; Uterine Contraction; Uterus; Vanadates; Vasodilator Agents; Virulence Factors, Bordetella | 1998 |
Subarachnoid hemorrhage and the role of potassium channels in relaxations of canine basilar artery to nitrovasodilators.
Topics: 4-Aminopyridine; Animals; Basilar Artery; Charybdotoxin; Cyclic GMP; Dogs; Female; Humans; Male; Molsidomine; Nitroprusside; Potassium Channels; Subarachnoid Hemorrhage; Uridine Triphosphate; Vasodilation; Vasodilator Agents | 1998 |
The NO/cGMP pathway and the development of neural networks in postembryonic lobsters.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Central Nervous System; Cyclic GMP; Female; Ganglia, Invertebrate; Larva; Molsidomine; Nephropidae; Nerve Net; Nerve Tissue Proteins; Neuronal Plasticity; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Penicillamine; Signal Transduction; Smell | 1998 |
Nitrergic and cholinergic innervation of the rat lower urinary tract after pelvic ganglionectomy.
Topics: Acetylcholine; Animals; Carbachol; Cyclic GMP; Electric Stimulation; Female; Ganglia; Ganglionectomy; Immunohistochemistry; Molsidomine; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Parasympathomimetics; Rats; Rats, Sprague-Dawley; Urethra; Urinary Bladder; Urinary Tract | 1998 |
Possible involvement of nitric oxide-cGMP pathway in the negative chronotropic effect of CD-832, a novel dihydropyridine derivative.
Topics: Animals; Calcium Channel Blockers; Cyclic GMP; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Molsidomine; Niacinamide; Nifedipine; Nitric Oxide | 1998 |
Nitric oxide superoxide and peroxynitrite modulate osteoclast activity.
Topics: Animals; Animals, Newborn; Bone Resorption; Calcium; Catalase; Cells, Cultured; Cyclic GMP; Enzyme Activation; Hydrogen Peroxide; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Osteoclasts; Rats; Rats, Sprague-Dawley; Superoxides; Thionucleotides | 1998 |
Exogenous nitric oxide inhibits mesangial cell adhesion to extracellular matrix components.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Collagen; Cyclic GMP; Cytoskeleton; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glomerular Mesangium; Glutathione; Molsidomine; Nitric Oxide; Nitroprusside; Nitroso Compounds; Penicillamine; Protein-Tyrosine Kinases; Rats; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Signal Transduction | 1998 |
Nitric oxide donor NOR 3 inhibits ketogenesis from oleate in isolated rat hepatocytes by a cyclic GMP-independent mechanism.
Topics: Adenosine Triphosphate; Animals; Benzoates; Calcium; Cells, Cultured; Cyclic GMP; Imidazoles; Lactic Acid; Liver; Male; Molsidomine; Nitric Oxide; Nitro Compounds; Oleic Acid; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Sodium Nitrite; Vasodilator Agents | 1998 |
Evidence that different mechanisms underlie smooth muscle relaxation to nitric oxide and nitric oxide donors in the rabbit isolated carotid artery.
Topics: Acetylcholine; Animals; Apamin; Calcimycin; Carotid Arteries; Cell Membrane; Cyclic GMP; Glyburide; In Vitro Techniques; Membrane Potentials; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Penicillamine; Peptides; Potassium Channel Blockers; Rabbits | 1998 |
Exogenous nitric oxide reduces oxygen consumption of isolated ventricular myocytes less than other forms of guanylate cyclase stimulation.
Topics: Animals; Cells, Cultured; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Heart; Heart Ventricles; Molsidomine; Myocardium; Nitric Oxide; Oxygen Consumption; Rabbits | 1998 |
Involvement of intracellular Ca2+ stores in inhibitory effects of NO donor SIN-1 and cGMP.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Animals; Apamin; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Carbachol; Charybdotoxin; Cyclic GMP; Egtazic Acid; Glyburide; Ileum; In Vitro Techniques; Indoles; Kinetics; Male; Molsidomine; Muscle Contraction; Muscle, Smooth; Peptides; Potassium Channels; Rats; Rats, Wistar; Tetraethylammonium; Tetrodotoxin; Thionucleotides | 1998 |
Effects of nitric oxide on adenylyl cyclase stimulation in N18TG2 neuroblastoma cells.
Topics: Adenylyl Cyclase Inhibitors; Animals; Calmodulin; Colforsin; Cyclic AMP; Cyclic GMP; GTP-Binding Protein alpha Subunits, Gi-Go; Mice; Molsidomine; Neuroblastoma; Nitric Oxide; Tumor Cells, Cultured | 1998 |
cGMP inhibits IP3-induced Ca2+ release in intact rat megakaryocytes via cGMP- and cAMP-dependent protein kinases.
Topics: Animals; Bone Marrow Cells; Calcium; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; Megakaryocytes; Models, Biological; Molsidomine; Nitric Oxide Donors; Nitroprusside; Photolysis; Rats; Rats, Wistar; Second Messenger Systems; Thionucleotides | 1998 |
Direct activation of K(Ca) channel in airway smooth muscle by nitric oxide: involvement of a nitrothiosylation mechanism?
Topics: Animals; Bronchi; Calcium; Charybdotoxin; Cyclic GMP; Dithiothreitol; Ethylmaleimide; Glutathione; Humans; Hydrazines; Lipid Bilayers; Male; Molsidomine; Muscle, Smooth; Nitric Oxide; Potassium Channels; Rats; Rats, Sprague-Dawley | 1998 |
Inhibitory effects of nitric oxide donors on nitric oxide synthesis in rat gastric myenteric plexus.
Topics: Animals; Calcium Channels; Citrulline; Cyclic GMP; Dose-Response Relationship, Drug; Gastric Mucosa; Male; Molsidomine; Muscle Relaxation; Myenteric Plexus; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Rats; Rats, Sprague-Dawley; Stomach; Vasoactive Intestinal Peptide | 1998 |
Angiotensin II-induced hypertrophy of adult rat cardiomyocytes is blocked by nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Angiotensin II; Animals; Bradykinin; Cardiomegaly; Cells, Cultured; Coculture Techniques; Cyclic GMP; Endothelium, Vascular; Heart; Iloprost; Indomethacin; Male; Molsidomine; Myocardium; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; omega-N-Methylarginine; Phenylalanine; Protein Biosynthesis; Rats; Rats, Sprague-Dawley | 1998 |
Protein kinase G expression in the small intestine and functional importance for smooth muscle relaxation.
Topics: Alkaloids; Animals; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Guinea Pigs; Indoles; Intestinal Mucosa; Intestine, Small; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth; Myenteric Plexus; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Polymerase Chain Reaction; Pyrroles; Rats; Rats, Wistar; Thionucleotides | 1998 |
Inhibitory effects of mesoionic 3-aryl substituted oxatriazole-5-imine derivatives on vascular smooth muscle cell mitogenesis and proliferation in vitro.
Topics: Animals; Cell Division; Cells, Cultured; Cyclic GMP; DNA; Male; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitrites; Penicillamine; Rats; Rats, Wistar; Signal Transduction; Triazoles; Urea | 1998 |
Rapid and delayed p42/p44 mitogen-activated protein kinase activation by nitric oxide: the role of cyclic GMP and tyrosine phosphatase inhibition.
Topics: Acetylcysteine; Animals; Biphenyl Compounds; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic GMP; Enzyme Activation; Free Radical Scavengers; Glomerular Mesangium; Glutathione; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molsidomine; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Onium Compounds; Oxadiazoles; Oxazines; Phosphorylation; Protein Processing, Post-Translational; Protein Tyrosine Phosphatases; Rats; S-Nitrosoglutathione; Second Messenger Systems | 1998 |
Nitrate tolerance is specific for nitric acid esters and its recovery requires an intact protein synthesis.
Topics: Animals; Cell Line; Cyclic GMP; Cycloheximide; Kinetics; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Nitroglycerin; Nitroprusside; Protein Biosynthesis; Spermine; Vasodilator Agents | 1998 |
The NO-cGMP pathway in the rat locus coeruleus: electrophysiological, immunohistochemical and in situ hybridization studies.
Topics: Animals; Cyclic GMP; Excitatory Postsynaptic Potentials; Fluorescent Antibody Technique, Indirect; Hydrazines; In Situ Hybridization; In Vitro Techniques; Locus Coeruleus; Male; Molsidomine; Neural Pathways; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley | 1998 |
Neuronal death induced by SIN-1 in the presence of superoxide dismutase: protection by cyclic GMP.
Topics: Animals; Cell Death; Cyclic GMP; Drug Synergism; Enzyme Inhibitors; Hydrogen Peroxide; Molsidomine; Neurons; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Superoxide Dismutase; Vasodilator Agents | 1998 |
Inhibitory innervation of the guinea-pig urethra; roles of CO, NO and VIP.
Topics: Animals; Carbon Monoxide; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Female; Fluorescent Antibody Technique; Ganglia, Autonomic; Guinea Pigs; Heme Oxygenase (Decyclizing); Immunohistochemistry; Molsidomine; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Sodium-Potassium-Exchanging ATPase; Urethra; Urinary Bladder; Vasoactive Intestinal Peptide; Xanthenes | 1998 |
Regulation of noradrenaline release by S-nitroso-cysteine: inhibition in PC12 cells in a cyclic GMP-independent manner.
Topics: Animals; Calcium; Cyclic GMP; Cysteine; Molsidomine; Nitric Oxide; Nitroprusside; Nitroso Compounds; Norepinephrine; PC12 Cells; Rats; S-Nitrosothiols | 1998 |
Inhibition of primate spinothalamic tract neurons by spinal glycine and GABA is modulated by guanosine 3',5'-cyclic monophosphate.
Topics: Animals; Cyclic GMP; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glycine; Guanylate Cyclase; Iontophoresis; Macaca fascicularis; Male; Microdialysis; Molsidomine; Neural Inhibition; Neurons; Nitric Oxide Donors; Receptors, GABA; Receptors, Glycine; Spinothalamic Tracts | 1999 |
Regulation of neuronal growth cone filopodia by nitric oxide.
Topics: Animals; Calcium; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Growth Cones; Guanylate Cyclase; Hydrazines; Molsidomine; Mutagens; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Nitroprusside; Oxadiazoles; Pseudopodia; Quinoxalines; Snails; Sulfhydryl Reagents | 1999 |
The nitric oxide donor SIN-1 is free of tolerance and maintains its cyclic GMP stimulatory potency in nitrate-tolerant LLC-PK1 cells.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Guanylate Cyclase; LLC-PK1 Cells; Molsidomine; Mutagens; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Nitroglycerin; Nitroprusside; Spermine; Swine; Vasodilator Agents | 1999 |
Actions of 8-bromo-cyclic-GMP on neurones in the rat thalamus in vivo and in vitro.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cyclic GMP; Evoked Potentials, Visual; Excitatory Amino Acid Agonists; Geniculate Bodies; Guanylate Cyclase; In Vitro Techniques; Molsidomine; N-Methylaspartate; Neurons, Afferent; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Wistar | 1999 |
Positive and negative inotropic effects of NO donors in atrial and ventricular fibres of the frog heart.
Topics: Aminoquinolines; Animals; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Half-Life; Heart; Heart Atria; Heart Ventricles; In Vitro Techniques; Molsidomine; Muscle Fibers, Skeletal; Myocardial Contraction; Nitric Oxide Donors; Nitroprusside; Penicillamine; Rana esculenta; S-Nitroso-N-Acetylpenicillamine | 1999 |
Up-regulation of heme-binding protein 23 (HBP23) gene expression by lipopolysaccharide is mediated via a nitric oxide-dependent signaling pathway in rat Kupffer cells.
Topics: Animals; Carrier Proteins; Cell Survival; Cells, Cultured; Cyclic GMP; Cytochrome-B(5) Reductase; Gene Expression Regulation; Heme-Binding Proteins; Hemeproteins; Kinetics; Kupffer Cells; Lipopolysaccharides; Male; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Penicillamine; Protein Biosynthesis; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Transcription, Genetic | 1999 |
Cyclic GMP regulates cromakalim-induced relaxation in the rat aortic smooth muscle: role of cyclic GMP in K(ATP)-channels.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Apamin; Calcium; Charybdotoxin; Cromakalim; Cyclic GMP; Endothelium, Vascular; Glyburide; In Vitro Techniques; Male; Methylene Blue; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Inbred WKY | 1999 |
Nitric oxide-releasing compounds inhibit neutrophil adhesion to endothelial cells.
Topics: Animals; CD11 Antigens; CD18 Antigens; Cell Adhesion; Coculture Techniques; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Molsidomine; Neutrophils; Nitric Oxide Donors; Rabbits; Thionucleotides; Triazoles; Tumor Necrosis Factor-alpha | 1999 |
Peroxynitrite is a positive inotropic agent in atrial and ventricular fibres of the frog heart.
Topics: Aminoquinolines; Animals; Atrial Function; Catalase; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Heart Atria; Heart Ventricles; Hydroxyl Radical; Molsidomine; Muscle Fibers, Skeletal; Myocardial Contraction; Myocardium; Nitrates; Nitric Oxide Donors; Oxadiazoles; Oxidants; Quinoxalines; Rana esculenta; Sodium; Sodium-Calcium Exchanger; Ventricular Function | 1999 |
Dioclein, a new nitric oxide- and endothelium-dependent vasodilator flavonoid.
Topics: Animals; Aorta, Thoracic; Brazil; Cyclic GMP; Endothelium, Vascular; Flavanones; Flavonoids; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Nitric Oxide; Phenylephrine; Plant Roots; Plants, Medicinal; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasodilator Agents | 1999 |
Decreased synthesis and vasodilation to nitric oxide in piglets with hypoxia-induced pulmonary hypertension.
Topics: Animals; Animals, Newborn; Arginine; Blood Vessels; Cyclic GMP; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pulmonary Circulation; Swine; Vasodilation; Vasodilator Agents | 2000 |
Impaired relaxation of stomach smooth muscle in mice lacking cyclic GMP-dependent protein kinase I.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Electric Stimulation; Female; Fluorescent Antibody Technique; Immunohistochemistry; Male; Mice; Mice, Knockout; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroarginine; Receptor Cross-Talk; Signal Transduction; Stomach; Vasoactive Intestinal Peptide | 2000 |
Cyclic GMP attenuates cyclic AMP-stimulated inotropy and oxygen consumption in control and hypertrophic hearts.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Cyclic AMP; Cyclic GMP; Isoproterenol; Molsidomine; Myocardial Contraction; Oxygen Consumption; Rabbits; Vasodilator Agents | 2000 |
NO(+) but not NO radical relaxes airway smooth muscle via cGMP-independent release of internal Ca(2+).
Topics: 4-Aminopyridine; Animals; Bronchi; Calcium; Calcium-Transporting ATPases; Charybdotoxin; Cyclic GMP; Dithiothreitol; Dogs; Enzyme Activation; Free Radicals; Guanylate Cyclase; Humans; In Vitro Techniques; Molsidomine; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Oxidation-Reduction; Penicillamine; Potassium Channels; Potassium Chloride; Tetraethylammonium; Trachea | 2000 |
Heme oxygenase-1 is a cGMP-inducible endothelial protein and mediates the cytoprotective action of nitric oxide.
Topics: Animals; Cattle; Cell Survival; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Induction; Heme Oxygenase (Decyclizing); Molsidomine; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Pulmonary Artery; Second Messenger Systems | 2000 |
Two distinct mechanisms of nitric oxide-mediated neuronal cell death show thiol dependency.
Topics: Acetylcysteine; Animals; Cell Death; Cell Differentiation; Cell Line; Cell Survival; Cyclic GMP; Hydrazines; Molsidomine; Necrosis; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidants; Sulfhydryl Compounds | 2000 |
Major potassium conductance in type I hair cells from rat semicircular canals: characterization and modulation by nitric oxide.
Topics: 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic GMP; Gluconates; Guanylate Cyclase; Hair Cells, Vestibular; Membrane Potentials; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Patch-Clamp Techniques; Penicillamine; Potassium; Potassium Channel Blockers; Rats; Rats, Long-Evans; Semicircular Canals; Signal Transduction | 2000 |
A common pathway for nitric oxide release from NO-aspirin and glyceryl trinitrate.
Topics: Animals; Aspirin; Cell Line; Cyclic GMP; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Epithelial Cells; Free Radical Scavengers; Imidazoles; Kidney; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Protein Binding; Swine | 2000 |
Nitric oxide modulates mechanical strain-induced activation of p38 MAPK in mesangial cells.
Topics: Animals; Biological Transport; Cells, Cultured; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Fluorescent Antibody Technique; Glomerular Mesangium; Imidazoles; Mitogen-Activated Protein Kinases; Molsidomine; Nitric Oxide; Nitric Oxide Donors; p38 Mitogen-Activated Protein Kinases; Penicillamine; Pyridines; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Stress, Mechanical | 2000 |
Nitric oxide-induced cGMP accumulation in the mouse bladder is not related to smooth muscle relaxation.
Topics: Animals; Arginine; Carbachol; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; In Vitro Techniques; Mice; Mice, Inbred BALB C; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Phosphodiesterase Inhibitors; Piperazines; Piperidines; Purines; Quinazolines; Sildenafil Citrate; Sulfones; Urethra; Urinary Bladder | 2000 |
Cyclooxygenase-derived products, rather than nitric oxide, are endothelium-derived relaxing factor(s) in the ventral aorta of carp (Cyprinus carpio).
Topics: Acetylcholine; Animals; Aorta; Calcimycin; Carps; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Ionophores; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Phenylephrine; Rats; Rats, Wistar; Vasodilator Agents | 2000 |
cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation.
Topics: Animals; Cyclic GMP; Diethylamines; Drug Combinations; Enzyme Inhibitors; Glutathione; In Vitro Techniques; Male; Molsidomine; Myocardial Contraction; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nucleotides, Cyclic; Oxadiazoles; Oxidation-Reduction; Quinoxalines; Rats; Rats, Wistar; Superoxide Dismutase | 2000 |
Role of cGMP-inhibited phosphodiesterase and sarcoplasmic calcium in mediating the increase in basal heart rate with nitric oxide donors.
Topics: Animals; Calcium; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Heart Atria; Heart Rate; Hydrazines; Indoles; Isoquinolines; Male; Milrinone; Models, Biological; Molsidomine; Nitric Oxide Donors; Nitrogen Oxides; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Aggregation Inhibitors; Pyrroles; Quinazolines; Ryanodine; Sarcoplasmic Reticulum; Signal Transduction; Spectrometry, Fluorescence; Sulfonamides; Superoxide Dismutase; Tetrahydroisoquinolines; Thionucleotides; Time Factors; Vasodilator Agents | 2000 |
Regulation of neuronal growth cone filopodia by nitric oxide depends on soluble guanylyl cyclase.
Topics: Animals; Cells, Cultured; Cyclic GMP; Ganglia, Invertebrate; Growth Cones; Guanylate Cyclase; Molsidomine; NADPH Dehydrogenase; Nervous System; Nitric Oxide; Nitric Oxide Donors; Potassium Chloride; Snails | 2001 |
The dual effect of a nitric oxide donor in nociception.
Topics: Animals; Chronic Disease; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hemoglobins; Injections, Spinal; Ligation; Male; Molsidomine; Nerve Compression Syndromes; Neuralgia; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Sciatic Nerve | 2001 |
Evidence that nitric oxide-induced synthesis of cGMP occurs in a paracrine but not an autocrine fashion and that the site of its release can be regulated: studies in dorsal root ganglia in vivo and in vitro.
Topics: Animals; Animals, Newborn; Autocrine Communication; Axotomy; Bradykinin; Capsaicin; Carbon-Nitrogen Ligases; Cells, Cultured; Cyclic GMP; Female; Ganglia, Spinal; Immunohistochemistry; Male; Molsidomine; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oligodendroglia; Paracrine Communication; Rats; Rats, Wistar; Sciatic Nerve | 2001 |
Nitric oxide reduces energy supply by direct action on the respiratory chain in isolated cardiomyocytes.
Topics: Adenosine; Alkaloids; Animals; Calcium; Carbazoles; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Electron Transport; Energy Metabolism; Enzyme Inhibitors; Indoles; Molsidomine; Muscle Fibers, Skeletal; Myocardium; NAD; Nitric Oxide; Nitric Oxide Donors; Oxygen Consumption; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine | 2001 |
Effects of nitric oxide and peroxynitrite on endotoxin-induced leukocyte adhesion to endothelium.
Topics: Animals; Cattle; Cell Adhesion; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Interferon-gamma; Leukocytes; Lipopolysaccharides; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Triazenes | 2001 |
NO-induced relaxation of labouring and non-labouring human myometrium is not mediated by cyclic GMP.
Topics: Charybdotoxin; Cyclic GMP; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Humans; In Vitro Techniques; Labor, Obstetric; Molsidomine; Muscle Relaxation; Muscle, Smooth; Myometrium; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Oxytocin; Penicillamine; Peptides; Pregnancy; Quinoxalines; S-Nitrosothiols; Scorpion Venoms; Time Factors; Uterus | 2001 |
The effects of SIN-1 on contractility and cyclic GMP levels in the pregnant mouse uterus.
Topics: Acetylcholine; Animals; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; In Vitro Techniques; Isometric Contraction; Methylene Blue; Mice; Molsidomine; Nitric Oxide Donors; Pregnancy; Uterine Contraction; Uterus | 2001 |
Exogenous nitric oxide inhibits VCAM-1 expression in human peritoneal mesothelial cells. Role of cyclic GMP and NF-kappaB.
Topics: Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Humans; Interleukin-1; Lipopolysaccharides; Molsidomine; NF-kappa B; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Peritoneum; Signal Transduction; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2002 |
Nitric oxide-cGMP-mediated vasoconstriction and effects of acetylcholine in the branchial circulation of the eel.
Topics: Acetylcholine; Animals; Arginine; Branchial Region; Cyclic GMP; Dose-Response Relationship, Drug; Eels; Endothelium, Vascular; Female; Gills; Hemoglobins; In Vitro Techniques; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Vasoconstriction | 2002 |
Effect of SIN-1 in rat ventricular myocytes: interference with beta-adrenergic stimulation.
Topics: Animals; Caffeine; Calcium; Calcium Channels; Cyclic AMP; Cyclic GMP; Drug Interactions; Heart Ventricles; In Vitro Techniques; Molsidomine; Myocardium; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Vasodilator Agents | 2002 |
Exogenous nitric oxide inhibits tumor necrosis factor-alpha- or interleukin-1-beta-induced monocyte chemoattractant protein-1 expression in human mesangial cells. Role of IkappaB-alpha and cyclic GMP.
Topics: Cells, Cultured; Chemokine CCL2; Cyclic GMP; Glomerular Mesangium; Guanylate Cyclase; Humans; I-kappa B Proteins; Interleukin-1; Molsidomine; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Protein Binding; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha | 2002 |
Nitric oxide inhibits capacitative Ca2+ entry by suppression of mitochondrial Ca2+ handling.
Topics: Barium; Calcium; Cell Line; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Humans; Intracellular Membranes; Membrane Potentials; Mitochondria; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Oxygen Consumption; Peroxynitrous Acid; Quinoxalines; Thapsigargin; Time Factors | 2002 |
Effects of various nitric oxide-donating drugs on adrenergic tension of human seminal vesicles in vitro.
Topics: Adrenergic alpha-Agonists; Aged; Colforsin; Cyclic GMP; Ejaculation; Erectile Dysfunction; Humans; In Vitro Techniques; Isometric Contraction; Male; Middle Aged; Molsidomine; Muscle Contraction; Muscle, Smooth; Nitric Oxide Donors; Nitroprusside; Norepinephrine; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Seminal Vesicles; Sexual Dysfunction, Physiological; Signal Transduction | 2003 |
Increased sensitivity to endothelial nitric oxide (NO) contributes to arterial normotension in mice with vascular smooth muscle-selective deletion of the atrial natriuretic peptide (ANP) receptor.
Topics: Acetylcholine; Administration, Oral; Animals; Aorta; Arteries; Blood Pressure; Blotting, Western; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Guanylate Cyclase; Mice; Mice, Knockout; Molsidomine; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Protein Structure, Tertiary; Receptors, Atrial Natriuretic Factor; Vasodilator Agents | 2003 |
Opposite nociceptive effects of the arginine/NO/cGMP pathway stimulation in dermal and subcutaneous tissues.
Topics: Animals; Arginine; Bucladesine; Cyclic GMP; Dermis; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Subcutaneous; Male; Molsidomine; Nitric Oxide; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Subcutaneous Tissue; Time Factors | 2003 |
Dissociation of cGMP accumulation and relaxation in myometrial smooth muscle: effects of S-nitroso-N-acetylpenicillamine and 3-morpholinosyndonimine.
Topics: Animals; Calcium; Calcium Signaling; Cell Adhesion Molecules; Cyclic GMP; Dose-Response Relationship, Drug; Female; Fura-2; Guinea Pigs; Microfilament Proteins; Molsidomine; Muscle Contraction; Muscle, Smooth; Myometrium; Nitric Oxide; Nitric Oxide Donors; Oxytocin; Phosphoproteins; Phosphorylation; S-Nitroso-N-Acetylpenicillamine; Up-Regulation | 2003 |
Effects of exogenous nitric oxide on the function of isolated working hearts.
Topics: Animals; Coronary Circulation; Cyclic GMP; Heart; Molsidomine; Myocardial Contraction; Myocardium; Nitric Oxide; Nitric Oxide Donors | 1999 |
Cyclic AMP and cyclic GMP independent stimulation of ventricular calcium current by peroxynitrite donors in guinea pig myocytes.
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Cyclic AMP; Cyclic GMP; Guinea Pigs; Heart Ventricles; Metalloporphyrins; Molsidomine; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Pyrogallol; Superoxide Dismutase; Up-Regulation | 2003 |
Role of the nitric oxide/cyclic GMP pathway and ascorbic acid in 3-morpholinosydnonimine (SIN-1)-induced increases in dopamine secretion from PC12 cells. A microdialysis in vitro study.
Topics: Animals; Antioxidants; Ascorbic Acid; Calcium; Calcium Channel Blockers; Cyclic GMP; Dialysis; Dopamine; Drug Interactions; In Vitro Techniques; Molsidomine; Nifedipine; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; PC12 Cells; Potassium; Rats; Signal Transduction; Time Factors | 2003 |
NO/cyclic GMP pathway mediates the relaxation of feline lower oesophageal sphincter.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Esophagogastric Junction; In Vitro Techniques; Indomethacin; Male; Methylene Blue; Molsidomine; Muscle Relaxation; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Signal Transduction; Vasoactive Intestinal Peptide | 2003 |
Reduction in [D-Ala2, NMePhe4, Gly-ol5]enkephalin-induced peripheral antinociception in diabetic rats: the role of the L-arginine/nitric oxide/cyclic guanosine monophosphate pathway.
Topics: Analgesics, Opioid; Animals; Arginine; Blood Glucose; Cyclic GMP; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Formaldehyde; Guanylate Cyclase; Male; Methylene Blue; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Pain; Pain Measurement; Rats; Rats, Wistar | 2004 |
Participation of the NO-cyclic GMP pathway in rofecoxib-induced antinociception.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Isoenzymes; Lactones; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Pain; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Wistar; Sulfones; Uric Acid | 2003 |
Role of cyclic GMP on inhibition by nitric oxide donors of human eosinophil chemotaxis in vitro.
Topics: Adolescent; Adult; Blotting, Western; Cell Survival; Chemotaxis, Leukocyte; Cyclic GMP; Eosinophils; Female; Humans; In Vitro Techniques; Male; Middle Aged; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Nitric Oxide Donors; Nitroprusside; Penicillamine; Tetrazolium Salts; Thiazoles; Tyrosine | 2004 |
A common pathway of nitric oxide release from AZD3582 and glyceryl trinitrate.
Topics: Animals; Cyclic GMP; Cyclooxygenase Inhibitors; LLC-PK1 Cells; Molsidomine; Naphthalenes; Naproxen; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Swine | 2004 |
High and low gain switches for regulation of cAMP efflux concentration: distinct roles for particulate GC- and soluble GC-cGMP-PDE3 signaling in rabbit atria.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Animals; Atrial Natriuretic Factor; Biological Transport; Cardiac Pacing, Artificial; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Inhibitors; Guanylate Cyclase; Heart Atria; Milrinone; Molsidomine; Myocardial Contraction; Myocytes, Cardiac; Natriuretic Peptide, C-Type; Nitric Oxide Donors; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazoles; Pyridines; Quinoxalines; Rabbits; Receptors, Cytoplasmic and Nuclear; Second Messenger Systems; Soluble Guanylyl Cyclase; Stroke Volume | 2004 |
Nitric oxide activates glibenclamide-sensitive K+ channels in urinary bladder myocytes through a c-GMP-dependent mechanism.
Topics: Adenosine Triphosphate; Animals; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Glyburide; Guinea Pigs; Indoles; Ion Channel Gating; Male; Membrane Potentials; Molsidomine; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Patch-Clamp Techniques; Potassium Channels; Quinoxalines; Signal Transduction; Urinary Bladder | 2004 |
Role of anions in nitric oxide-induced short-circuit current increase in isolated porcine ciliary processes.
Topics: Animals; Anion Transport Proteins; Anions; Aqueous Humor; Carbonic Anhydrase Inhibitors; Chloride Channels; Ciliary Body; Corneal Stroma; Cyclic GMP; Electric Conductivity; Enzyme Inhibitors; Guanylate Cyclase; Ion Exchange; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Protein Kinase Inhibitors; Swine; Thionucleotides | 2004 |
Insulin sensitivity is mediated by the activation of the ACh/NO/cGMP pathway in rat liver.
Topics: Acetylcholine; Animals; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Injections, Intravenous; Insulin Resistance; Liver; Male; Molsidomine; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Portal Vein; Quinoxalines; Rats; Rats, Wistar; Signal Transduction | 2004 |
No hemoglobin but NO: the icefish (Chionodraco hamatus) heart as a paradigm.
Topics: Animals; Antarctic Regions; Arginine; Cardiotonic Agents; Cell Respiration; Cyclic GMP; Electrochemistry; Fluorescent Antibody Technique; Molsidomine; Myocardial Contraction; Myocardium; NADH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oceans and Seas; Ornithine; Perciformes | 2004 |
Nitric oxide stimulates gamma-aminobutyric acid release and inhibits glycine release in retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Cadmium; Citrulline; Cyclic GMP; DEET; Dizocilpine Maleate; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Free Radical Scavengers; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Immunohistochemistry; In Vitro Techniques; Molsidomine; Neural Inhibition; Nipecotic Acids; Nitric Oxide; Potassium; Retina; Silver Staining; Thiourea; Turtles; Vigabatrin | 2005 |
Adenosine/nitric oxide crosstalk in the branchial circulation of Squalus acanthias and Anguilla anguilla.
Topics: Adenosine; Anguilla; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Female; Hypoxia; In Vitro Techniques; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Perfusion; Pressure; Signal Transduction; Squalus acanthias; Time Factors; Vasodilation | 2005 |
Involvement of guanylyl cyclase, protein kinase A and Na+ K+ ATPase in relaxations of bovine isolated bronchioles induced by GEA 3175, an NO donor.
Topics: Animals; Bronchi; Calcium; Cattle; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Guanylate Cyclase; In Vitro Techniques; Molsidomine; Muscle Relaxation; Nitric Oxide; Nitric Oxide Donors; Ouabain; Oxadiazoles; Peptides; Potassium; Quinoxalines; S-Nitrosoglutathione; Serotonin; Sodium-Potassium-Exchanging ATPase; Thionucleotides; Triazoles | 2006 |
Peroxynitrite generation and tyrosine nitration in defense responses in tobacco BY-2 cells.
Topics: Algal Proteins; Aniline Compounds; Antibodies, Anti-Idiotypic; Cells, Cultured; Cyclic GMP; Fluoresceins; Fungal Proteins; Molsidomine; Nicotiana; Nitric Oxide; Peroxynitrous Acid; Phytophthora; Proteins; Reactive Oxygen Species; Superoxides; Tyrosine; Uric Acid | 2006 |
Direct comparison of relaxation and cGMP production in human coronary by-pass grafts in response to stimulation with natriuretic peptides and a nitric oxide donor.
Topics: Adult; Aged; Aged, 80 and over; Atrial Natriuretic Factor; Coronary Artery Bypass; Cyclic GMP; Dose-Response Relationship, Drug; Female; Humans; Internal Mammary-Coronary Artery Anastomosis; Male; Mammary Arteries; Middle Aged; Molsidomine; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Natriuretic Peptides; Nitric Oxide Donors; Saphenous Vein; Tissue Culture Techniques; Vasodilation; Vasodilator Agents | 2006 |
Impaired cerebrovascular reactivity after cortical spreading depression in rats: Restoration by nitric oxide or cGMP.
Topics: Analysis of Variance; Animals; Cerebral Cortex; Cerebrovascular Circulation; Cerebrovascular Disorders; Cortical Spreading Depression; Cyclic GMP; Drug Interactions; Hypercapnia; Laser-Doppler Flowmetry; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Rats; Rats, Wistar; Spermine; Thionucleotides; Time Factors | 2006 |
Effects of nitric oxide-active drugs on the discharge of subthalamic neurons: microiontophoretic evidence in the rat.
Topics: Action Potentials; Analysis of Variance; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Iontophoresis; Male; Molsidomine; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Wistar; S-Nitrosoglutathione; Subthalamic Nucleus; Thionucleotides; Time Factors | 2006 |
Modulation of voltage-gated Ca2+ current in vestibular hair cells by nitric oxide.
Topics: Animals; Calcium Channels, L-Type; Carbazoles; Cell Separation; Cyclic GMP; Data Interpretation, Statistical; Enzyme Inhibitors; Ethylmaleimide; Free Radical Scavengers; Hair Cells, Vestibular; In Vitro Techniques; Indoles; Molsidomine; Nitric Oxide; Nitroprusside; Patch-Clamp Techniques; Rats; Rats, Long-Evans; Signal Transduction | 2007 |
Nitric oxide modulates ionic transport in the isolated intestine of the eel, Anguilla anguilla.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Anguilla; Animals; Arginine; Bicarbonates; Chlorides; Cyclic GMP; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Intestinal Absorption; Intestinal Mucosa; Intestines; Membrane Potentials; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Permeability; Quinoxalines; Time Factors | 2007 |
Signal transduction pathways affected by nitric oxide donors during neutrophil functional response in vitro.
Topics: Animals; CD11b Antigen; CD18 Antigens; Cell Adhesion; Cyclic GMP; Guanylate Cyclase; Humans; Hydrazines; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Nitric Oxide; Nitric Oxide Donors; Respiratory Burst; Signal Transduction | 2007 |
Cyclic AMP dependent down regulation in the relaxation of smooth muscle cells of cat esophagitis.
Topics: Adenylyl Cyclases; Animals; Blotting, Western; Bucladesine; Cats; Cell Membrane Permeability; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Down-Regulation; Esophagitis; In Vitro Techniques; Isoenzymes; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide Donors; Nitroprusside; Signal Transduction; Vasoactive Intestinal Peptide | 2007 |
Role of nitric oxide/cyclic GMP pathway in regulating spontaneous excitations in detrusor smooth muscle of the guinea-pig bladder.
Topics: Action Potentials; Animals; Calcium; Cyclic GMP; Electrophysiology; Female; Guinea Pigs; In Vitro Techniques; Indoles; Isometric Contraction; Male; Molsidomine; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Phosphodiesterase Inhibitors; Piperazines; Purines; Signal Transduction; Sildenafil Citrate; Sulfones; Urinary Bladder | 2008 |
The role of nitric oxide and cGMP in somatostatin's protection against retinal ischemia.
Topics: Animals; Choline O-Acetyltransferase; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Fluorescent Antibody Technique, Indirect; In Situ Nick-End Labeling; Ischemia; Molsidomine; Nitric Oxide; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Retinal Diseases; Retinal Vessels; Somatostatin; Spermine | 2008 |
In vivo electrophysiology of dopamine-denervated striatum: focus on the nitric oxide/cGMP signaling pathway.
Topics: Action Potentials; Analysis of Variance; Animals; Corpus Striatum; Cyclic GMP; Denervation; Dopamine; Dose-Response Relationship, Radiation; Electric Stimulation; Enzyme Inhibitors; Male; Molsidomine; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidopamine; Rats; Rats, Wistar; Signal Transduction; Sympatholytics | 2008 |
Nitric oxide modulates the frog heart ventricle morphodynamics.
Topics: Animals; Anura; Arginine; Cyclic GMP; Female; Heart Ventricles; In Vitro Techniques; Indazoles; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Perfusion; Serine; Software; Ventricular Function | 2008 |
Morphological and physiological study of the cardiac NOS/NO system in the Antarctic (Hb-/Mb-) icefish Chaenocephalus aceratus and in the red-blooded Trematomus bernacchii.
Topics: Animals; Antarctic Regions; Arginine; Blotting, Western; Cyclic GMP; Endocardium; Female; Fluorescent Antibody Technique; Heart Ventricles; Hemodynamics; Male; Molsidomine; Myocardium; NADPH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Perciformes; Signal Transduction; Stroke Volume | 2009 |
Nitric oxide- and cGMP-active compounds affect the discharge of substantia nigra pars reticulata neurons: in vivo evidences in the rat.
Topics: Action Potentials; Animals; Cyclic GMP; Down-Regulation; Enzyme Inhibitors; Iontophoresis; Male; Molsidomine; Neural Inhibition; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Signal Transduction; Substantia Nigra; Up-Regulation | 2009 |
Cyclic guanosine monophosphate signaling cascade mediates pigment aggregation in freshwater shrimp chromatophores.
Topics: Aminoquinolines; Animals; Brazil; Chromatophores; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Fresh Water; Guanylate Cyclase; Molsidomine; Nitroprusside; Palaemonidae; Pigments, Biological; Protoporphyrins; Signal Transduction | 2009 |
Elevated plasma concentration of NO and cGMP may be responsible for the decreased platelet aggregation and platelet leukocyte conjugation in platelets hypo-responsive to catecholamines.
Topics: Adenosine Triphosphate; Adult; Asian People; Blood Platelets; Catecholamines; Cyclic AMP; Cyclic GMP; Female; Humans; Leukocyte Common Antigens; Leukocytes; Male; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Platelet Aggregation; Platelet Aggregation Inhibitors; Young Adult | 2009 |
Investigation of relaxant effects of new agents affecting nitric oxide/cyclic guanosine monophosphate pathway on sheep oddi sphincter.
Topics: Animals; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Guanylate Cyclase; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Sheep; Sphincter of Oddi; Triazenes | 2010 |
Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Endothelial Cells; Enzyme Activation; Free Radical Scavengers; Hypertension, Pulmonary; Metalloporphyrins; Molsidomine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Polyethylene Glycols; Protein Processing, Post-Translational; Pulmonary Artery; Pulmonary Circulation; Second Messenger Systems; Sheep; Spermine; Superoxide Dismutase; Vasodilation; Vasodilator Agents | 2011 |
In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways.
Topics: Animals; Blood Platelets; Cyclic GMP; Humans; Male; Molsidomine; Nitric Oxide Donors; Nitroprusside; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Conformation; Rats; Rats, Sprague-Dawley; Receptors, Fibrinogen; S-Nitrosoglutathione | 2011 |
Intimal hyperplasia in balloon dilated coronary arteries is reduced by local delivery of the NO donor, SIN-1 via a cGMP-dependent pathway.
Topics: Actins; Analysis of Variance; Angioplasty, Balloon, Coronary; Animals; Coronary Angiography; Coronary Restenosis; Coronary Vessels; Cyclic GMP; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Guanylate Cyclase; Hyperplasia; Intermediate Filaments; Molsidomine; Myosins; NAD(P)H Dehydrogenase (Quinone); NADP; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Signal Transduction; Sus scrofa; Time Factors; Tunica Intima | 2011 |