lignans and ergosta-4-6-8(14)-22-tetraen-3-one

lignans has been researched along with ergosta-4-6-8(14)-22-tetraen-3-one* in 1 studies

Other Studies

1 other study(ies) available for lignans and ergosta-4-6-8(14)-22-tetraen-3-one

Article	Year
A new lignan glycoside from the aerial parts and cytotoxic investigation of Uvaria rufa. Natural product research, 2015, Volume: 29, Issue:3 Chemical investigation of the aerial parts of Uvaria rufa (Dunal) Blume collected from Vietnam yielded one new lignan glycoside, ufaside (1), along with six known compounds, oxoanolobine (2), ergosta-4,6,8(14),22-tetraen-3-one (3), catechin (4), epicatechin (5), daucosterol (6) and glutin-5-en-3-one (7). Their chemical structures were determined by using NMR, HR-MS spectroscopic analyses and in comparison with the reported data. A cytotoxic analysis of U. rufa herb extracts was performed for the first time using nine human cancer cell lines (MCF-7, MDA-MB-231, LNCaP, MKN7, SW480, KB, LU-1, HepG2 and HL-60) derived from different tumour types. Of these seven constituents, compounds 2 and 3 displayed moderate cytotoxicity against the human lung adenocarcinoma cell line (LU-1) with IC50 values of 9.22 ± 1.02 μg/mL and 10.21 ± 1.16 μg/mL, respectively. Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cholestenones; Drug Screening Assays, Antitumor; Glycosides; Humans; Lignans; Molecular Structure; Plant Components, Aerial; Plant Extracts; Uvaria	2015

Article

Year

A new lignan glycoside from the aerial parts and cytotoxic investigation of Uvaria rufa.

Natural product research, 2015, Volume: 29, Issue:3

Chemical investigation of the aerial parts of Uvaria rufa (Dunal) Blume collected from Vietnam yielded one new lignan glycoside, ufaside (1), along with six known compounds, oxoanolobine (2), ergosta-4,6,8(14),22-tetraen-3-one (3), catechin (4), epicatechin (5), daucosterol (6) and glutin-5-en-3-one (7). Their chemical structures were determined by using NMR, HR-MS spectroscopic analyses and in comparison with the reported data. A cytotoxic analysis of U. rufa herb extracts was performed for the first time using nine human cancer cell lines (MCF-7, MDA-MB-231, LNCaP, MKN7, SW480, KB, LU-1, HepG2 and HL-60) derived from different tumour types. Of these seven constituents, compounds 2 and 3 displayed moderate cytotoxicity against the human lung adenocarcinoma cell line (LU-1) with IC50 values of 9.22 ± 1.02 μg/mL and 10.21 ± 1.16 μg/mL, respectively.

Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cholestenones; Drug Screening Assays, Antitumor; Glycosides; Humans; Lignans; Molecular Structure; Plant Components, Aerial; Plant Extracts; Uvaria

2015